BCL10

Summary

Gene Symbol: BCL10
Description: B cell CLL/lymphoma 10
Alias: CARMEN, CIPER, CLAP, IMD37, c-E10, mE10, B-cell lymphoma/leukemia 10, CARD containing molecule enhancing NF-kB, CARD-containing apoptotic signaling protein, CARD-containing molecule enhancing NF-kappa-B, CARD-containing proapoptotic protein, CED-3/ICH-1 prodomain homologous E10-like regulator, cCARMEN, caspase-recruiting domain-containing protein, cellular homolog of vCARMEN, cellular-E10, hCLAP, mammalian CARD-containing adapter molecule E10
Species: human
Products:     BCL10

Top Publications

  1. Srinivasula S, Ahmad M, Lin J, Poyet J, Fernandes Alnemri T, Tsichlis P, et al. CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-kappaB activation and apoptosis. J Biol Chem. 1999;274:17946-54 pubmed
    ..Expression of the CARD domain of human CLAP abrogates tumor necrosis factor-alpha-induced NF-kappaB activation, suggesting that cellular CLAP plays an ..
  2. Koseki T, Inohara N, Chen S, Carrio R, Merino J, Hottiger M, et al. CIPER, a novel NF kappaB-activating protein containing a caspase recruitment domain with homology to Herpesvirus-2 protein E10. J Biol Chem. 1999;274:9955-61 pubmed
    We have identified and characterized CIPER, a novel protein containing a caspase recruitment domain (CARD) in its N terminus and a C-terminal region rich in serine and threonine residues...
  3. Qiao Q, Yang C, Zheng C, Fontan L, David L, Yu X, et al. Structural architecture of the CARMA1/Bcl10/MALT1 signalosome: nucleation-induced filamentous assembly. Mol Cell. 2013;51:766-79 pubmed publisher
    The CARMA1/Bcl10/MALT1 (CBM) signalosome mediates antigen receptor-induced NF-?B signaling to regulate multiple lymphocyte functions...
  4. Bidère N, Ngo V, Lee J, Collins C, Zheng L, Wan F, et al. Casein kinase 1alpha governs antigen-receptor-induced NF-kappaB activation and human lymphoma cell survival. Nature. 2009;458:92-6 pubmed publisher
    ..an NF-kappaB activating platform containing the scaffold protein CARMA1 (also called CARD11), the adaptor BCL10 and the paracaspase MALT1 (the CBM complex), linked to the inhibitor of NF-kappaB kinase complex, but signal ..
  5. Coornaert B, Baens M, Heyninck K, Bekaert T, Haegman M, Staal J, et al. T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20. Nat Immunol. 2008;9:263-71 pubmed publisher
    ..Our studies identify A20 as a substrate of MALT1 and emphasize the importance of MALT1 proteolytic activity in the 'fine tuning' of T cell antigen receptor signaling. ..
  6. Oeckinghaus A, Wegener E, Welteke V, Ferch U, Arslan S, Ruland J, et al. Malt1 ubiquitination triggers NF-kappaB signaling upon T-cell activation. EMBO J. 2007;26:4634-45 pubmed
    ..T-cell receptor (TCR) engagement induces the formation of the Carma1-Bcl10-Malt1 (CBM) complex that is essential for activation of the IkappaB kinase (IKK)/NF-kappaB pathway...
  7. Hu S, Du M, Park S, Alcivar A, Qu L, Gupta S, et al. cIAP2 is a ubiquitin protein ligase for BCL10 and is dysregulated in mucosa-associated lymphoid tissue lymphomas. J Clin Invest. 2006;116:174-81 pubmed
    ..MALT) lymphomas is associated with independent chromosomal translocations that lead to the upregulation of either BCL10 or MALT1 or the generation of a fusion protein, cIAP2-MALT1...
  8. Thome M. CARMA1, BCL-10 and MALT1 in lymphocyte development and activation. Nat Rev Immunol. 2004;4:348-59 pubmed
  9. Zhou H, Wertz I, O Rourke K, Ultsch M, Seshagiri S, Eby M, et al. Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO. Nature. 2004;427:167-71 pubmed
    ..b>Bcl10 is essential for NF-kappaB activation by T- and B-cell receptors...

More Information

Publications88

  1. Uren A, O Rourke K, Aravind L, Pisabarro M, Seshagiri S, Koonin E, et al. Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma. Mol Cell. 2000;6:961-7 pubmed
    ..The human paracaspase prodomain binds Bcl10, a protein involved in the t(1;14)(p22;q32) translocation of mucosa-associated lymphoid tissue (MALT) lymphoma...
  2. Yan M, Lee J, Schilbach S, Goddard A, Dixit V. mE10, a novel caspase recruitment domain-containing proapoptotic molecule. J Biol Chem. 1999;274:10287-92 pubmed
    ..We have identified a novel mammalian CARD-containing adaptor molecule termed mE10 (mammalian E10)...
  3. Apostolou S, De Rienzo A, Murthy S, Jhanwar S, Testa J. Absence of BCL10 mutations in human malignant mesothelioma. Cell. 1999;97:684-6; discussion 686-8 pubmed
  4. Borthakur A, Bhattacharyya S, Dudeja P, Tobacman J. Carrageenan induces interleukin-8 production through distinct Bcl10 pathway in normal human colonic epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2007;292:G829-38 pubmed
    ..IL-8, IL-8 promoter activity, total and nuclear NF-kappaB, IkappaBalpha, phospho-IkappaBalpha, and Bcl10 were assessed by immunohistochemistry, Western blot, ELISA, and cDNA microarray...
  5. Yoneda T, Imaizumi K, Maeda M, Yui D, Manabe T, Katayama T, et al. Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein. J Biol Chem. 2000;275:11114-20 pubmed
    To elucidate the function of Bcl10, recently cloned as an apoptosis-associated gene mutated in MALT lymphoma, we identified its binding partner TRAF2, which mediates signaling via tumor necrosis factor receptors...
  6. Lucas P, Yonezumi M, Inohara N, McAllister Lucas L, Abazeed M, Chen F, et al. Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway. J Biol Chem. 2001;276:19012-9 pubmed
    ..The first, t(1;14), results in the transfer of the entire Bcl10 gene to chromosome 14 wherein Bcl10 expression is inappropriately stimulated by the neighboring Ig enhancer...
  7. Wang D, You Y, Lin P, Xue L, Morris S, Zeng H, et al. Bcl10 plays a critical role in NF-kappaB activation induced by G protein-coupled receptors. Proc Natl Acad Sci U S A. 2007;104:145-50 pubmed
    ..b>Bcl10 is an essential adaptor molecule connecting antigen receptor signaling cascades to NF-kappaB activation in ..
  8. Thome M, Martinon F, Hofmann K, Rubio V, Steiner V, Schneider P, et al. Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinase. J Biol Chem. 1999;274:9962-8 pubmed
    ..Here we report on the structure and function of the E10 gene product of equine herpesvirus-2, designated v-CARMEN, and on its cellular homologue, c-CARMEN, which contain a caspase-recruiting domain (CARD) motif...
  9. Costanzo A, Guiet C, Vito P. c-E10 is a caspase-recruiting domain-containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor-kappaB. J Biol Chem. 1999;274:20127-32 pubmed
    ..Thus, our results suggest that c-E10 is an adapter protein that activates NF-kappaB through a molecular pathway involved in death receptor signaling. ..
  10. Ruland J, Duncan G, Elia A, del Barco Barrantes I, Nguyen L, Plyte S, et al. Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure. Cell. 2001;104:33-42 pubmed
    b>Bcl10, a CARD-containing protein identified from the t(1;14)(p22;q32) breakpoint in MALT lymphomas, has been shown to induce apoptosis and activate NF-kappaB in vitro...
  11. Bidere N, Snow A, Sakai K, Zheng L, Lenardo M. Caspase-8 regulation by direct interaction with TRAF6 in T cell receptor-induced NF-kappaB activation. Curr Biol. 2006;16:1666-71 pubmed
    ..Caspase-8 is activated after TCR stimulation and nucleates a complex with B cell lymphoma 10 (BCL10), paracaspase MALT1, and the inhibitors of kappaB kinase (IKK) complex [4]...
  12. Zhang Q, Siebert R, Yan M, Hinzmann B, Cui X, Xue L, et al. Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32). Nat Genet. 1999;22:63-8 pubmed
    ..Here we describe overexpression of BCL10, a novel apoptotic signalling gene that encodes an amino-terminal caspase recruitment domain (CARD), in MALT ..
  13. Wu C, Ashwell J. NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-kappaB activation. Proc Natl Acad Sci U S A. 2008;105:3023-8 pubmed publisher
    The mechanism by which the Carma1-Bcl10-MALT1 (CBM) complex couples T cell antigen receptor (TCR) signaling to IkappaB kinase (IKK) and NF-kappaB activation is not known...
  14. Sommer K, Guo B, Pomerantz J, Bandaranayake A, Moreno Garcia M, Ovechkina Y, et al. Phosphorylation of the CARMA1 linker controls NF-kappaB activation. Immunity. 2005;23:561-74 pubmed
    ..This PKC-dependent switch regulates accessibility of the CARD and CC domains and controls assembly and full activation of the membrane-associated IkappaB kinase (IKK) signalosome. ..
  15. Nakagawa M, Hosokawa Y, Yonezumi M, Izumiyama K, Suzuki R, Tsuzuki S, et al. MALT1 contains nuclear export signals and regulates cytoplasmic localization of BCL10. Blood. 2005;106:4210-6 pubmed
    MALT1, BCL10 (B-cell lymphoma 10), and API2 (apoptosis inhibitor 2)-MALT1 are key molecules in mucosa-associated lymphoid tissue (MALT) lymphomagenesis...
  16. Bhattacharyya S, Borthakur A, Tyagi S, Gill R, Chen M, Dudeja P, et al. B-cell CLL/lymphoma 10 (BCL10) is required for NF-kappaB production by both canonical and noncanonical pathways and for NF-kappaB-inducing kinase (NIK) phosphorylation. J Biol Chem. 2010;285:522-30 pubmed publisher
    B-cell CLL/lymphoma 10 (BCL10), the caspase recruitment domain (CARD)-containing protein involved in the etiology of the mucosa-associated lymphoid tissue (MALT) lymphomas, has been implicated in inflammatory processes in epithelial ..
  17. Willis T, Jadayel D, Du M, Peng H, Perry A, Abdul Rauf M, et al. Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types. Cell. 1999;96:35-45 pubmed
    MALT B cell lymphomas with t(1;14)(p22;q32) showed a recurrent breakpoint upstream of the promoter of a novel gene, Bcl10. Bcl10 is a cellular homolog of the equine herpesvirus-2 E10 gene: both contain an amino-terminal caspase ..
  18. Sun L, Deng L, Ea C, Xia Z, Chen Z. The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes. Mol Cell. 2004;14:289-301 pubmed
    The CARD domain protein BCL10 and paracaspase MALT1 are essential for the activation of IkappaB kinase (IKK) and NF-kappaB in response to T cell receptor (TCR) stimulation...
  19. Maes B, Demunter A, Peeters B, De Wolf Peeters C. BCL10 mutation does not represent an important pathogenic mechanism in gastric MALT-type lymphoma, and the presence of the API2-MLT fusion is associated with aberrant nuclear BCL10 expression. Blood. 2002;99:1398-404 pubmed
    ..The first, t(11;18)(q21;q21), results in the fusion protein API2-MLT (API2-MALT1). Through t(1;14)(p22;q32), the BCL10 gene is entirely transferred to the IgH gene, resulting in its overexpression...
  20. Yui D, Yoneda T, Oono K, Katayama T, Imaizumi K, Tohyama M. Interchangeable binding of Bcl10 to TRAF2 and cIAPs regulates apoptosis signaling. Oncogene. 2001;20:4317-23 pubmed
    b>Bcl10 was identified as a candidate gene responsible for low grade B cell lymphomas of mucosa-associated lymphoid tissue...
  21. Gaide O, Favier B, Legler D, Bonnet D, Brissoni B, Valitutti S, et al. CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation. Nat Immunol. 2002;3:836-43 pubmed
    ..CARMA1 interacts with Bcl10 via its caspase-recruitment domain (CARD)...
  22. McAllister Lucas L, Ruland J, Siu K, Jin X, Gu S, Kim D, et al. CARMA3/Bcl10/MALT1-dependent NF-kappaB activation mediates angiotensin II-responsive inflammatory signaling in nonimmune cells. Proc Natl Acad Sci U S A. 2007;104:139-44 pubmed
    ..pathway mediating Ang II-dependent activation of NF-kappaB, which is composed of three principal proteins, CARMA3, Bcl10, and MALT1...
  23. Daniilidis K, Georges P, Tibesku C, Prehm P. Positive side effects of Ca antagonists for osteoarthritic joints-results of an in vivo pilot study. J Orthop Surg Res. 2015;10:1 pubmed publisher
    ..Adalat, Amlodipine, Carmen, Nitrendipin, and Norvasc lead to an improvement...
  24. Malki I, Cantrelle F, Sottejeau Y, Lippens G, Lambert J, Landrieu I. Regulation of the interaction between the neuronal BIN1 isoform 1 and Tau proteins - role of the SH3 domain. FEBS J. 2017;284:3218-3229 pubmed publisher
    ..Interestingly, a 334-376 peptide from the clathrin and AP-2-binding domain (CLAP) domain of BIN1Iso1, which contains a SH3-binding site, is able to compete with BIN1-SH3 intramolecular interaction...
  25. Zeng H, Di L, Fu G, Chen Y, Gao X, Xu L, et al. Phosphorylation of Bcl10 negatively regulates T-cell receptor-mediated NF-kappaB activation. Mol Cell Biol. 2007;27:5235-45 pubmed
    b>Bcl10 (B-cell lymphoma 10) is an adaptor protein comprised of an N-terminal caspase recruitment domain and a C-terminal serine/threonine-rich domain...
  26. Yang Z, Zhang J, Jiang D, Khatri P, Solow Cordero D, Toesca D, et al. A Human Genome-Wide RNAi Screen Reveals Diverse Modulators that Mediate IRE1?-XBP1 Activation. Mol Cancer Res. 2018;16:745-753 pubmed publisher
    ..Several genes, including BCL10, GCLM, and IGF1R, correlated with worse relapse-free survival (RFS) in an analysis of patients with ..
  27. Satpathy S, Wagner S, Beli P, Gupta R, Kristiansen T, Malinova D, et al. Systems-wide analysis of BCR signalosomes and downstream phosphorylation and ubiquitylation. Mol Syst Biol. 2015;11:810 pubmed publisher
    ..In addition, we show that BCL10 is modified by LUBAC-mediated linear ubiquitylation, and demonstrate an important function of LUBAC in BCR-induced ..
  28. Asllanaj B, Kragt L, Voshol I, Koudstaal M, Kuijpers M, Xi T, et al. Dentition Patterns in Different Unilateral Cleft Lip Subphenotypes. J Dent Res. 2017;96:1482-1489 pubmed publisher
    ..within the categories cleft lip with or without alveolus (CL ± A) and cleft lip, alveolus and palate (CLAP), whether different CL subphenotypes based on morphological severity of the cleft show different dentition patterns ..
  29. Kalantari P, Morales Y, Miller E, Jaramillo L, Ponichtera H, Wuethrich M, et al. CD209a Synergizes with Dectin-2 and Mincle to Drive Severe Th17 Cell-Mediated Schistosome Egg-Induced Immunopathology. Cell Rep. 2018;22:1288-1300 pubmed publisher
    ..trigger an FcR?-dependent signaling cascade that involves the tyrosine kinase Syk and the trimolecular Card9-Bcl10-Malt1 complex, CD209a promotes the sustained activation of Raf-1...
  30. Gossler H, Maier L, Angeli S, Tischer S, Deutschmann O. CaRMeN: a tool for analysing and deriving kinetics in the real world. Phys Chem Chem Phys. 2018;20:10857-10876 pubmed publisher
    This paper presents the concepts of an open software tool (CaRMeN) that can be used to rapidly analyse and derive models, in particular chemical kinetics. The software automates the workflow of comparing model vs...
  31. Ohnuma K, Uchiyama M, Yamochi T, Nishibashi K, Hosono O, Takahashi N, et al. Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1. J Biol Chem. 2007;282:10117-31 pubmed
    ..Ligation of CD26 by caveolin-1 recruits a complex consisting of CD26, CARMA1, Bcl10, and IkappaB kinase to lipid rafts...
  32. McCully R, Pomerantz J. The protein kinase C-responsive inhibitory domain of CARD11 functions in NF-kappaB activation to regulate the association of multiple signaling cofactors that differentially depend on Bcl10 and MALT1 for association. Mol Cell Biol. 2008;28:5668-86 pubmed publisher
    ..as an inhibitory domain (ID) that controls the association of CARD11 with multiple signaling cofactors, including Bcl10, TRAF6, TAK1, IKKgamma, and caspase-8, through an interaction that requires both the caspase recruitment domain (..
  33. Du M. MALT lymphoma: Genetic abnormalities, immunological stimulation and molecular mechanism. Best Pract Res Clin Haematol. 2017;30:13-23 pubmed publisher
    ..The three translocations seen in MALT lymphoma, namely t(14;18)(q32;q21)/IGH-MALT1, t(1;14)(p22;q32)/BCL10-IGH, and t(11;18)(q21;q21)/BIRC3 (API2)-MALT1 are capable of activating both canonical and non-canonical NF-?B ..
  34. Murphy D, Adhikari D, Webster D, Yen J. Underwater flight by the planktonic sea butterfly. J Exp Biol. 2016;219:535-43 pubmed publisher
    ..generate extra lift by peeling their wings apart at the beginning of the power stroke (the well-known Weis-Fogh 'clap-and-fling' mechanism)...
  35. Yang Y, Kelly P, Shaffer A, Schmitz R, Yoo H, Liu X, et al. Targeting Non-proteolytic Protein Ubiquitination for the Treatment of Diffuse Large B Cell Lymphoma. Cancer Cell. 2016;29:494-507 pubmed publisher
    ..of the activated B cell-like (ABC) subtype of diffuse large B cell lymphoma (DLBCL), engages the CARD11-MALT1-BCL10 (CBM) adapter complex to activate I?B kinase (IKK) and the classical NF-?B pathway...
  36. McAllister Lucas L, Inohara N, Lucas P, Ruland J, Benito A, Li Q, et al. Bimp1, a MAGUK family member linking protein kinase C activation to Bcl10-mediated NF-kappaB induction. J Biol Chem. 2001;276:30589-97 pubmed
    b>Bcl10 and MALT1, products of distinct chromosomal translocations in mucosa-associated lymphoid tissue lymphoma, cooperate in activating NF-kappaB...
  37. Marinis J, Hutti J, Homer C, Cobb B, Cantley L, McDonald C, et al. I?B kinase ? phosphorylation of TRAF4 downregulates innate immune signaling. Mol Cell Biol. 2012;32:2479-89 pubmed publisher
  38. Welteke V, Eitelhuber A, Duwel M, Schweitzer K, Naumann M, Krappmann D. COP9 signalosome controls the Carma1-Bcl10-Malt1 complex upon T-cell stimulation. EMBO Rep. 2009;10:642-8 pubmed publisher
    The Carma1-Bcl10-Malt1 (CBM) complex connects T-cell receptor (TCR) signalling to the canonical IkappaB kinase (IKK)/NF (nuclear factor)-kappaB pathway...
  39. Dong W, Liu Y, Peng J, Chen L, Zou T, Xiao H, et al. The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4. J Biol Chem. 2006;281:26029-40 pubmed
    Our previous studies have revealed that the signaling protein BCL10 plays a major role in adaptive immunity by mediating NF-kappaB activation in the LPS/TLR4 pathway...
  40. Ginster S, Bardet M, Unterreiner A, Malinverni C, Renner F, Lam S, et al. Two Antagonistic MALT1 Auto-Cleavage Mechanisms Reveal a Role for TRAF6 to Unleash MALT1 Activation. PLoS ONE. 2017;12:e0169026 pubmed publisher
    ..Here, co-expression of MALT1 in HEK293 cells, either with activated CARD11 and BCL10 or with TRAF6, was used to explore the mechanism of MALT1 activation at the molecular level...
  41. Abd Ellah A, Voogdt C, Krappmann D, Moller P, Marienfeld R. GSK3β modulates NF-κB activation and RelB degradation through site-specific phosphorylation of BCL10. Sci Rep. 2018;8:1352 pubmed publisher
    ..More recently, GSK3β has been identified as a part of a protein complex involved in the regulation of the CARMA1-BCL10-MALT1 complex (CBM complex) formation, which is a key signalling event upon antigen receptor engagement of B and T ..
  42. Van Nuffel E, Schmitt A, Afonina I, Schulze Osthoff K, Beyaert R, Hailfinger S. CARD14-Mediated Activation of Paracaspase MALT1 in Keratinocytes: Implications for Psoriasis. J Invest Dermatol. 2017;137:569-575 pubmed publisher
    ..CARD14 forms a signaling complex with BCL10 and the paracaspase MALT1, and this process is enhanced upon pathogenic CARD14 mutation, culminating in the ..
  43. Yang Y, Yang C, Chan W, Wang Z, Deibel K, Pomerantz J. Molecular Determinants of Scaffold-induced Linear Ubiquitinylation of B Cell Lymphoma/Leukemia 10 (Bcl10) during T Cell Receptor and Oncogenic Caspase Recruitment Domain-containing Protein 11 (CARD11) Signaling. J Biol Chem. 2016;291:25921-25936 pubmed
    ..During TCR signaling, the adaptor protein Bcl10 is inducibly recruited to the CARD11 scaffold protein as part of a multicomponent complex that induces I?B kinase (..
  44. Bhattacharyya S, Borthakur A, Dudeja P, Tobacman J. Lipopolysaccharide-induced activation of NF-?B non-canonical pathway requires BCL10 serine 138 and NIK phosphorylations. Exp Cell Res. 2010;316:3317-27 pubmed publisher
    ..b>BCL10 was silenced by siRNA and effects of mutations of specific phosphorylation sites of BCL10 (Ser138Gly and Ser218Gly)..
  45. Shen L, Liang A, Au W, Lu L, Chen Y, Wong K, et al. BCL10 mutations are irrelevant to its aberrant nuclear localization in nasal NK/T-cell lymphoma. Leukemia. 2003;17:2240-2 pubmed
  46. Damiano J, Stehlik C, Pio F, Godzik A, Reed J. CLAN, a novel human CED-4-like gene. Genomics. 2001;75:77-83 pubmed
    ..The CARD of the CLAN proteins binds a number of other CARD-containing proteins including caspase-1, BCL10, NOD2, and NAC...
  47. Wan J, Zhang C, Zeng G, Huang D, Hu L, Huang C, et al. Synthesis and evaluation of a new class of stabilized nano-chlorapatite for Pb immobilization in sediment. J Hazard Mater. 2016;320:278-288 pubmed publisher
    ..30 to 0mg/L after 45-d treatment. The increase of available phosphorus in both SDS-nClAP and ClAP treated sediment samples verified dissolution-precipitation mechanism involved in Pb immobilization...
  48. Hatchi E, Poalas K, Cordeiro N, N Debi M, Gavard J, Bidere N. Participation of the E3-ligase TRIM13 in NF-?B p65 activation and NFAT-dependent activation of c-Rel upon T-cell receptor engagement. Int J Biochem Cell Biol. 2014;54:217-22 pubmed publisher
    ..We further observed that c-Rel induction was diminished without TRIM13, as NFAT activation was compromised. These results unveil that TRIM13 is a selective regulator of p65 and of c-Rel activation. ..
  49. Schreuder M, van den Brand M, Hebeda K, Groenen P, van Krieken J, Scheijen B. Novel developments in the pathogenesis and diagnosis of extranodal marginal zone lymphoma. J Hematop. 2017;10:91-107 pubmed publisher
    ..25% of the cases is the presence of specific chromosomal translocations involving the genes MALT1 and BCL10, which lead to activation of the NF-?B signaling pathway...
  50. Borovecki A, Korac P, Ventura R, Perisa M, Banham A, Dominis M. MALT1, BCL10 and FOXP1 in salivary gland mucosa-associated lymphoid tissue lymphomas. Pathol Int. 2007;57:47-51 pubmed
    ..B cell CLL/lymphoma 10 (BCL10) and forkhead box PA (FOXP1) protein expression were studied by immunohistochemistry and translocations identified ..
  51. Hacker H, Karin M. Regulation and function of IKK and IKK-related kinases. Sci STKE. 2006;2006:re13 pubmed
    ..Together, the IKKs and IKK-related kinases are instrumental for activation of the host defense system. This Review focuses on the functions of IKK and IKK-related kinases and the molecular mechanisms that regulate their activities. ..
  52. Ishiguro K, Ando T, Goto H, Xavier R. Bcl10 is phosphorylated on Ser138 by Ca2+/calmodulin-dependent protein kinase II. Mol Immunol. 2007;44:2095-100 pubmed
    Ordered assembly of scaffold proteins Carma1-Bcl10-Malt1 determines NF-kappaB activation following T cell receptor (TCR) engagement...
  53. Ma C, Stinson J, Zhang Y, Abbott J, Weinreich M, Hauk P, et al. Germline hypomorphic CARD11 mutations in severe atopic disease. Nat Genet. 2017;49:1192-1201 pubmed publisher
    ..Our findings indicate that a single hypomorphic mutation in CARD11 can cause potentially correctable cellular defects that lead to atopic dermatitis. ..
  54. Khoynezhad A, Toluie S, Al Atassi T. Treatment of the Chronic Type B Aortic Dissection: The Pro-endovascular Argument. Semin Thorac Cardiovasc Surg. 2017;29:131-136 pubmed publisher
    ..This controversy stems from anatomical differences between acute and chronic dissections, such as a thicker intimal clap and improved results in descending aortic replacement...
  55. Afonina I, Van Nuffel E, Baudelet G, Driege Y, Kreike M, Staal J, et al. The paracaspase MALT1 mediates CARD14-induced signaling in keratinocytes. EMBO Rep. 2016;17:914-27 pubmed publisher
    ..Collectively, our findings demonstrate a novel role for MALT1 in CARD14-induced signaling and indicate MALT1 as a valuable therapeutic target in psoriasis. ..
  56. Kim M, Park D, Oh I, Kim Y, Choi S, Jung S, et al. Increased expression of Dec-205, Bcl-10, Tim-3, and Trem-1 mRNA in chronic otitis media with cholesteatoma. Acta Otolaryngol. 2014;134:475-80 pubmed publisher
    ..05 each). However, mRNA abundance was not associated with patient sex, hearing level, presence of bacteria or history of reoperation (p > 0.05 each). ..
  57. Wang L, Guo Y, Huang W, Ke X, Poyet J, Manji G, et al. Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B. J Biol Chem. 2001;276:21405-9 pubmed
    b>BCL10 belongs to the caspase recruitment domain (CARD) family of proteins that regulate apoptosis and NF-kappaB signaling pathways...
  58. Bertin J, Wang L, Guo Y, Jacobson M, Poyet J, Srinivasula S, et al. CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B. J Biol Chem. 2001;276:11877-82 pubmed
    ..The CARD domains of both CARD11 and CARD14 associate specifically with the CARD domain of BCL10, a signaling protein that activates NF-kappaB through the IkappaB kinase complex in response to upstream stimuli...
  59. Karim Z, Vemana H, Khasawneh F. MALT1-ubiquitination triggers non-genomic NF-κB/IKK signaling upon platelet activation. PLoS ONE. 2015;10:e0119363 pubmed publisher
    ..It was found that platelets express a functional proteasome, and form CARMA/MALT1/Bcl10 (CBM) complex when activated...
  60. Gringhuis S, Kaptein T, Wevers B, Theelen B, van der Vlist M, Boekhout T, et al. Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1? via a noncanonical caspase-8 inflammasome. Nat Immunol. 2012;13:246-54 pubmed publisher
    ..Thus, dectin-1 acted as an extracellular sensor for pathogens that induced both IL-1? production and maturation through a noncanonical caspase-8-dependent inflammasome for protective immunity. ..
  61. Hu S, Alcivar A, Qu L, Tang J, Yang X. CIAP2 inhibits anigen receptor signaling by targeting Bcl10 for degredation. Cell Cycle. 2006;5:1438-42 pubmed
    ..shown that cIAP2 normally inhibits antigen receptor signaling by mediating the ubiquitination and degradation of Bcl10, a critical component for antigenic signaling to NF-kappaB...
  62. Tian M, Gonzalez G, Scheer B, DeFranco A. Bcl10 can promote survival of antigen-stimulated B lymphocytes. Blood. 2005;106:2105-12 pubmed
    ..We isolated multiple copies of full-length, unmutated Bcl10, a signaling adaptor molecule encoded by a gene found to translocate to the immunoglobulin heavy chain (IgH) locus ..
  63. Kuo S, Yeh K, Wu M, Lin C, Wei M, Liou J, et al. First-line antibiotic therapy in Helicobacter pylori-negative low-grade gastric mucosa-associated lymphoid tissue lymphoma. Sci Rep. 2017;7:14333 pubmed publisher
    ..8%) of 16 antibiotic-unresponsive cases, but in none of the 9 antibiotic-responsive cases (P?=?0.027). Nuclear BCL10 expression was significantly higher in antibiotic-unresponsive tumors than in antibiotic-responsive tumors (14/16 [..
  64. Liu Y, Dong W, Chen L, Xiang R, Xiao H, De G, et al. BCL10 mediates lipopolysaccharide/toll-like receptor-4 signaling through interaction with Pellino2. J Biol Chem. 2004;279:37436-44 pubmed
    ..Herein, we demonstrate that BCL10, a critical molecule that signals between the T cell receptor and IkappaB kinase complexes, is involved in the ..
  65. Liu Y, Song R, Gao Y, Li Y, Wang S, Liu H, et al. Protein kinase C-? negatively regulates T cell receptor-induced NF-?B activation by inhibiting the assembly of CARMA1 signalosome. J Biol Chem. 2012;287:20081-7 pubmed publisher
    ..Upon stimulation, CARMA1 recruits downstream molecules including B-cell CLL/lymphoma 10 (Bcl10), mucosa-associated lymphoid tissue lymphoma translocation gene 1 (MALT1), and TRAF6 to assemble a specific TCR-..
  66. Nakamura K, Senda T, Sato K, Mori S, Moriyama M. Accumulation of BCL10 at the perinuclear region is required for the BCL10-mediated nuclear factor-kappa B activation. Pathobiology. 2005;72:191-202 pubmed
    The dysregulated overexpression of BCL10 that results from a specific chromosomal translocation t(1;14)(p22;q32) in mucosa-associated lymphoid tissue lymphoma has been shown to activate nuclear factor (NF)-kappaB, which may promote ..
  67. Li B, Yang W, Zhou X, Fan Y, Lu H, Shi D. [Abnormal BCL10 nuclear expression and chromosomal translocation in ocular adnexal mucosa-associated lymphoid tissue lymphomas]. Zhonghua Yan Ke Za Zhi. 2008;44:545-8 pubmed
    To detect the BCL10 expression and several types of chromosomal translocations [including t (11;18)/API2-MALT1; t (1;14)/IgH- BCL10 and t (14;18)/MALT1-IgH] in ocular adnexal mucosa-associated lymphoid tissue lymphomas (OA-MALT lymphomas)..
  68. Park Y, Jin H, Liu Y. Regulation of T cell function by the ubiquitin-specific protease USP9X via modulating the Carma1-Bcl10-Malt1 complex. Proc Natl Acad Sci U S A. 2013;110:9433-8 pubmed publisher
    ..Mechanistically, USP9X interacts with Bcl10 of the Carma1-Bcl10-Malt1 (CBM) complex and removes the TCR-induced ubiquitin chain from Bcl10, which facilitates ..
  69. Stilo R, Varricchio E, Liguoro D, Leonardi A, Vito P. A20 is a negative regulator of BCL10- and CARMA3-mediated activation of NF-kappaB. J Cell Sci. 2008;121:1165-71 pubmed publisher
    The molecular complex containing CARMA proteins, BCL10 and TRAF6 has been identified recently as a key component in the signal transduction pathways that regulate activation of the nuclear factor kappaB (NF-kappaB) transcription factor...
  70. Rivera J. Adaptors discriminate mast-cell cytokine production from eicosanoid production and degranulation. Trends Immunol. 2006;27:251-3 pubmed
    ..The CARMA1-Bcl10-Malt1 adaptor complex regulates NFkappaB activation by antigen receptors in lymphocytes...
  71. Kawano T, Iwase S, Nakayama R, Horiguchi Yamada J, Kobayashi M, Yamada H. Lack of BCL10 mRNA mutation in lymphold malignancies. Anticancer Res. 2002;22:305-9 pubmed
    b>BCL10, a gene involved in the chromosomal translocation t(1;14)(p22;q32) found in mucosa-associated lymphoid tissue lymphoma (MALT lymphoma), has shown mutation in not only MALT lymphomas but also other lymphold tumors...
  72. Ma Y, Liao Z, Xu Y, Zhong Z, Wang X, Zhang F, et al. Characteristics of CARMA1-BCL10-MALT1-A20-NF-κB expression in T cell-acute lymphocytic leukemia. Eur J Med Res. 2014;19:62 pubmed publisher
    ..of A20 and its regulating factors, including upstream regulators and the CBM complex, which includes CARMA1, BCL10, and MALT1...
  73. Bertoni F, Cavalli F, Cotter F, Zucca E. Genetic alterations underlying the pathogenesis of MALT lymphoma. Hematol J. 2002;3:10-3 pubmed
  74. Bhattacharyya S, Gill R, Chen M, Zhang F, Linhardt R, Dudeja P, et al. Toll-like receptor 4 mediates induction of the Bcl10-NFkappaB-interleukin-8 inflammatory pathway by carrageenan in human intestinal epithelial cells. J Biol Chem. 2008;283:10550-8 pubmed publisher
    ..and interleukin 8 (IL-8) in human colonic epithelial cells through a pathway of innate immunity mediated by Bcl10 (B-cell CLL/lymphoma 10)...
  75. Noels H, Somers R, Liu H, Ye H, Du M, De Wolf Peeters C, et al. Auto-ubiquitination-induced degradation of MALT1-API2 prevents BCL10 destabilization in t(11;18)(q21;q21)-positive MALT lymphoma. PLoS ONE. 2009;4:e4822 pubmed publisher
    ..or both immunoglobulin-like domains of MALT1 (approximately 90% of cases)--mediating the possible interaction with BCL10--fused to the RING domain of API2...
  76. Howes A, O Sullivan P, Breyer F, Ghose A, Cao L, Krappmann D, et al. Psoriasis mutations disrupt CARD14 autoinhibition promoting BCL10-MALT1-dependent NF-κB activation. Biochem J. 2016;473:1759-68 pubmed publisher
    ..contrast with wild-type CARD14, CARD14(E138A) and CARD14(G117S) psoriasis mutants interacted constitutively with BCL10 and MALT1, and triggered BCL10- and MALT1-dependent activation of NF-κB in keratinocytes...
  77. Edin S, Oruganti S, Grundström C, Grundström T. Interaction of calmodulin with Bcl10 modulates NF-kappaB activation. Mol Immunol. 2010;47:2057-64 pubmed publisher
    ..direct interaction with CaM in the pathway, and found that CaM interacts specifically with the signaling adaptor Bcl10. The binding is Ca(2+) dependent and of high affinity, with a K(d) of approximately 160 nM...
  78. Knies N, Alankus B, Weilemann A, Tzankov A, Brunner K, Ruff T, et al. Lymphomagenic CARD11/BCL10/MALT1 signaling drives malignant B-cell proliferation via cooperative NF-κB and JNK activation. Proc Natl Acad Sci U S A. 2015;112:E7230-8 pubmed publisher
    ..CARD11(L225LI) constitutively associated with B-cell CLL/lymphoma 10 (BCL10) and mucosa-associated lymphoid tissue lymphoma translocation gene 1 (MALT1) to simultaneously activate the NF-κ..
  79. Frischbutter S, Gabriel C, Bendfeldt H, Radbruch A, Baumgrass R. Dephosphorylation of Bcl-10 by calcineurin is essential for canonical NF-?B activation in Th cells. Eur J Immunol. 2011;41:2349-57 pubmed publisher
    ..Together, our findings demonstrate that CaN functions as a critical signaling molecule during Th cell activation, regulating Bcl-10 phosphorylation and thereby NF-?B activation. ..