BARD1

Summary

Gene Symbol: BARD1
Description: BRCA1 associated RING domain 1
Alias: BRCA1-associated RING domain protein 1, BRCA1-associated RING domain gene 1, RING-type E3 ubiquitin transferase BARD1
Species: human
Products:     BARD1

Top Publications

  1. Christensen D, Brzovic P, Klevit R. E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages. Nat Struct Mol Biol. 2007;14:941-8 pubmed
    ..strategy, we discovered six previously unidentified interactions between the human heterodimeric RING E3 BRCA1-BARD1 and the human E2s UbcH6, Ube2e2, UbcM2, Ubc13, Ube2k and Ube2w...
  2. Kim H, Chen J, Yu X. Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response. Science. 2007;316:1202-5 pubmed
    ..Together, these results suggest the existence of a ubiquitination-dependent signaling pathway involved in the DNA damage response. ..
  3. Morris J, Pangon L, Boutell C, Katagiri T, Keep N, Solomon E. Genetic analysis of BRCA1 ubiquitin ligase activity and its relationship to breast cancer susceptibility. Hum Mol Genet. 2006;15:599-606 pubmed
    ..of the Breast Cancer-1 predisposition protein (BRCA1) associates with the BRCA1-associated RING domain-1 protein (BARD1) to form a heterodimer, which exhibits ubiquitin ligase activity that is abrogated by known cancer-associated ..
  4. Westermark U, Reyngold M, Olshen A, Baer R, Jasin M, Moynahan M. BARD1 participates with BRCA1 in homology-directed repair of chromosome breaks. Mol Cell Biol. 2003;23:7926-36 pubmed
    ..Much of the BRCA1 in cells forms a heterodimeric complex with a structurally related protein BARD1. We report that expression of truncated mouse or human BARD1 peptides capable of interacting with Brca1 results in ..
  5. Kleiman F, Manley J. Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50. Science. 1999;285:1576-9 pubmed
    ..and in intact cells with a nuclear protein of previously unknown function, BRCA1-associated RING domain protein (BARD1). The BARD1-CstF-50 interaction inhibits polyadenylation in vitro...
  6. Sy S, Huen M, Chen J. PALB2 is an integral component of the BRCA complex required for homologous recombination repair. Proc Natl Acad Sci U S A. 2009;106:7155-60 pubmed publisher
    ....
  7. Stacey S, Sulem P, Johannsson O, Helgason A, Gudmundsson J, Kostic J, et al. The BARD1 Cys557Ser variant and breast cancer risk in Iceland. PLoS Med. 2006;3:e217 pubmed
    ..of the BRCA1 protein are mediated through heterodimeric complexes composed of BRCA1 and a related protein, BARD1. Some breast-cancer-associated BRCA1 missense mutations disrupt the function of the BRCA1/BARD1 complex...
  8. Vahteristo P, Syrjakoski K, Heikkinen T, Eerola H, Aittomaki K, von Smitten K, et al. BARD1 variants Cys557Ser and Val507Met in breast cancer predisposition. Eur J Hum Genet. 2006;14:167-72 pubmed
    b>BARD1 (BRCA1-associated RING-domain 1) is a tumor suppressor whose protein product interacts with BRCA1, and in which rare somatic and germline mutations have been reported in breast, uterine, and endometrial cancers...
  9. Bosse K, Diskin S, Cole K, Wood A, Schnepp R, Norris G, et al. Common variation at BARD1 results in the expression of an oncogenic isoform that influences neuroblastoma susceptibility and oncogenicity. Cancer Res. 2012;72:2068-78 pubmed publisher
    ..In this study, we characterized the high-risk neuroblastoma association at the BRCA1-related locus, BARD1, showing that disease-associated variations correlate with increased expression of the oncogenically activated ..
  10. Morris J, Keep N, Solomon E. Identification of residues required for the interaction of BARD1 with BRCA1. J Biol Chem. 2002;277:9382-6 pubmed
    The breast and ovarian cancer predisposition gene product BRCA1, binds to BARD1 at its N terminus. In cells BRCA1 is found as a heterodimer with BARD1 and may represent the functionally active form of BRCA1...

Detail Information

Publications62

  1. Christensen D, Brzovic P, Klevit R. E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages. Nat Struct Mol Biol. 2007;14:941-8 pubmed
    ..strategy, we discovered six previously unidentified interactions between the human heterodimeric RING E3 BRCA1-BARD1 and the human E2s UbcH6, Ube2e2, UbcM2, Ubc13, Ube2k and Ube2w...
  2. Kim H, Chen J, Yu X. Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response. Science. 2007;316:1202-5 pubmed
    ..Together, these results suggest the existence of a ubiquitination-dependent signaling pathway involved in the DNA damage response. ..
  3. Morris J, Pangon L, Boutell C, Katagiri T, Keep N, Solomon E. Genetic analysis of BRCA1 ubiquitin ligase activity and its relationship to breast cancer susceptibility. Hum Mol Genet. 2006;15:599-606 pubmed
    ..of the Breast Cancer-1 predisposition protein (BRCA1) associates with the BRCA1-associated RING domain-1 protein (BARD1) to form a heterodimer, which exhibits ubiquitin ligase activity that is abrogated by known cancer-associated ..
  4. Westermark U, Reyngold M, Olshen A, Baer R, Jasin M, Moynahan M. BARD1 participates with BRCA1 in homology-directed repair of chromosome breaks. Mol Cell Biol. 2003;23:7926-36 pubmed
    ..Much of the BRCA1 in cells forms a heterodimeric complex with a structurally related protein BARD1. We report that expression of truncated mouse or human BARD1 peptides capable of interacting with Brca1 results in ..
  5. Kleiman F, Manley J. Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50. Science. 1999;285:1576-9 pubmed
    ..and in intact cells with a nuclear protein of previously unknown function, BRCA1-associated RING domain protein (BARD1). The BARD1-CstF-50 interaction inhibits polyadenylation in vitro...
  6. Sy S, Huen M, Chen J. PALB2 is an integral component of the BRCA complex required for homologous recombination repair. Proc Natl Acad Sci U S A. 2009;106:7155-60 pubmed publisher
    ....
  7. Stacey S, Sulem P, Johannsson O, Helgason A, Gudmundsson J, Kostic J, et al. The BARD1 Cys557Ser variant and breast cancer risk in Iceland. PLoS Med. 2006;3:e217 pubmed
    ..of the BRCA1 protein are mediated through heterodimeric complexes composed of BRCA1 and a related protein, BARD1. Some breast-cancer-associated BRCA1 missense mutations disrupt the function of the BRCA1/BARD1 complex...
  8. Vahteristo P, Syrjakoski K, Heikkinen T, Eerola H, Aittomaki K, von Smitten K, et al. BARD1 variants Cys557Ser and Val507Met in breast cancer predisposition. Eur J Hum Genet. 2006;14:167-72 pubmed
    b>BARD1 (BRCA1-associated RING-domain 1) is a tumor suppressor whose protein product interacts with BRCA1, and in which rare somatic and germline mutations have been reported in breast, uterine, and endometrial cancers...
  9. Bosse K, Diskin S, Cole K, Wood A, Schnepp R, Norris G, et al. Common variation at BARD1 results in the expression of an oncogenic isoform that influences neuroblastoma susceptibility and oncogenicity. Cancer Res. 2012;72:2068-78 pubmed publisher
    ..In this study, we characterized the high-risk neuroblastoma association at the BRCA1-related locus, BARD1, showing that disease-associated variations correlate with increased expression of the oncogenically activated ..
  10. Morris J, Keep N, Solomon E. Identification of residues required for the interaction of BARD1 with BRCA1. J Biol Chem. 2002;277:9382-6 pubmed
    The breast and ovarian cancer predisposition gene product BRCA1, binds to BARD1 at its N terminus. In cells BRCA1 is found as a heterodimer with BARD1 and may represent the functionally active form of BRCA1...
  11. Xia Y, Pao G, Chen H, Verma I, Hunter T. Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein. J Biol Chem. 2003;278:5255-63 pubmed
    ..domain containing the RING finger, as well as that of the full-length BRCA1, was significantly enhanced by the BARD1 protein (residues 8-142), whose RING finger domain itself lacked Ub ligase activity in vitro...
  12. Zhou X, Han S, Wang S, Chen X, Dong J, Shi X, et al. Polymorphisms in HPV E6/E7 protein interacted genes and risk of cervical cancer in Chinese women: a case-control analysis. Gynecol Oncol. 2009;114:327-31 pubmed publisher
    Accumulating studies indicate that HPV E6/E7 oncoproteins interacting genes, TP53, BRCA1 and BARD1, play a critical role in cervical carcinogenesis...
  13. Edwards R, Lee M, Tsutakawa S, Williams R, Nazeer I, Kleiman F, et al. The BARD1 C-terminal domain structure and interactions with polyadenylation factor CstF-50. Biochemistry. 2008;47:11446-56 pubmed publisher
    The BARD1 N-terminal RING domain binds BRCA1 while the BARD1 C-terminal ankyrin and tandem BRCT repeat domains bind CstF-50 to modulate mRNA processing and RNAP II stability in response to DNA damage...
  14. Gorringe K, Choong D, Visvader J, Lindeman G, Campbell I. BARD1 variants are not associated with breast cancer risk in Australian familial breast cancer. Breast Cancer Res Treat. 2008;111:505-9 pubmed
    Several studies in various populations have suggested that non-synonymous BARD1 variants are associated with increased breast cancer risk...
  15. Dechend R, Hirano F, Lehmann K, Heissmeyer V, Ansieau S, Wulczyn F, et al. The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators. Oncogene. 1999;18:3316-23 pubmed
    ..The novel Bcl-3 interactors Jab1, Pirin, Tip60 and Bard1 are nuclear proteins which also bind to other transcription factors including c-Jun, nuclear factor I (NFI), HIV-1 ..
  16. Kleiman F, Wu Baer F, Fonseca D, Kaneko S, Baer R, Manley J. BRCA1/BARD1 inhibition of mRNA 3' processing involves targeted degradation of RNA polymerase II. Genes Dev. 2005;19:1227-37 pubmed
    Mammalian cells exhibit a complex response to DNA damage. The tumor suppressor BRCA1 and associated protein BARD1 are thought to play an important role in this response, and our previous work demonstrated that this includes transient ..
  17. Fabbro M, Savage K, Hobson K, Deans A, Powell S, McArthur G, et al. BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage. J Biol Chem. 2004;279:31251-8 pubmed
    ..The major BRCA1 binding partner, BARD1, is also implicated in the DNA damage response, and recent reports indicate that BRCA1 and BARD1 co-operate in ..
  18. Rodriguez J, Schüchner S, Au W, Fabbro M, Henderson B. Nuclear-cytoplasmic shuttling of BARD1 contributes to its proapoptotic activity and is regulated by dimerization with BRCA1. Oncogene. 2004;23:1809-20 pubmed
    The breast cancer-associated protein, BARD1, colocalizes with BRCA1 in nuclear foci in the S phase and after DNA damage, and the two proteins form a stable heterodimer implicated in DNA repair, protein ubiquitination, and control of mRNA ..
  19. Fabbro M, Schuechner S, Au W, Henderson B. BARD1 regulates BRCA1 apoptotic function by a mechanism involving nuclear retention. Exp Cell Res. 2004;298:661-73 pubmed
    ..BRCA1 is normally regulated by protein turnover, but is stabilized by BARD1 which can recruit BRCA1 to the nucleus to form a ubiquitin E3 ligase complex involved in DNA repair or cell ..
  20. Irminger Finger I, Leung W, Li J, Dubois Dauphin M, Harb J, Feki A, et al. Identification of BARD1 as mediator between proapoptotic stress and p53-dependent apoptosis. Mol Cell. 2001;8:1255-66 pubmed
    The BRCA1-associated protein BARD1 is a putative tumor suppressor...
  21. Wei L, Lan L, Hong Z, Yasui A, Ishioka C, Chiba N. Rapid recruitment of BRCA1 to DNA double-strand breaks is dependent on its association with Ku80. Mol Cell Biol. 2008;28:7380-93 pubmed publisher
    ..at DSBs depended on Ku80, which functions in the nonhomologous end-joining (NHEJ) pathway, independently of BARD1, which binds to the N terminus of BRCA1...
  22. Wu J, Vlastos A, Pelte M, Caligo M, Bianco A, Krause K, et al. Aberrant expression of BARD1 in breast and ovarian cancers with poor prognosis. Int J Cancer. 2006;118:1215-26 pubmed
    Mutations in tumor-suppressor gene BARD1 have been found in inherited and spontaneous breast, ovarian and uterine cancers...
  23. Thai T, Du F, Tsan J, Jin Y, Phung A, Spillman M, et al. Mutations in the BRCA1-associated RING domain (BARD1) gene in primary breast, ovarian and uterine cancers. Hum Mol Genet. 1998;7:195-202 pubmed
    ..The protein encoded by BRCA1 interacts in vivo with the BRCA1-associated RING domain (BARD1) protein...
  24. Mallery D, Vandenberg C, Hiom K. Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains. EMBO J. 2002;21:6755-62 pubmed
    ..In vivo, BRCA1 forms a heterodimeric complex with BARD1. Both proteins contain an N-terminal zinc RING-finger domain which confers E3 ubiquitin ligase activity...
  25. Yu X, Wu L, Bowcock A, Aronheim A, Baer R. The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression. J Biol Chem. 1998;273:25388-92 pubmed
    ..These results indicate that the BRCA1-CtIP interaction may be required for tumor suppression by BRCA1. ..
  26. Choudhury A, Xu H, Modi A, Zhang W, Ludwig T, Baer R. Hyperphosphorylation of the BARD1 tumor suppressor in mitotic cells. J Biol Chem. 2005;280:24669-79 pubmed
    ..In vivo, BRCA1 exists as a heterodimer with the BARD1 protein, and many of its biological functions are mediated by the BRCA1-BARD1 complex...
  27. Onay V, Briollais L, Knight J, Shi E, Wang Y, Wells S, et al. SNP-SNP interactions in breast cancer susceptibility. BMC Cancer. 2006;6:114 pubmed
    ..cell cycle and estrogen metabolism (CCND1-[Pro241Pro] and COMT-[Met108/158Val]), cell cycle and DNA repair (BARD1-[Pro24Ser] and XPD-[Lys751Gln]), and within carcinogen metabolism (GSTP1-[Ile105Val] and COMT-[Met108/158Val]) ..
  28. Hashizume R, Fukuda M, Maeda I, Nishikawa H, Oyake D, Yabuki Y, et al. The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation. J Biol Chem. 2001;276:14537-40 pubmed
    BRCA1-BARD1 constitutes a heterodimeric RING finger complex associated through its N-terminal regions...
  29. Ryser S, Dizin E, Jefford C, Delaval B, Gagos S, Christodoulidou A, et al. Distinct roles of BARD1 isoforms in mitosis: full-length BARD1 mediates Aurora B degradation, cancer-associated BARD1beta scaffolds Aurora B and BRCA2. Cancer Res. 2009;69:1125-34 pubmed publisher
    The BRCA1-associated ring domain protein 1 (BARD1) interacts with BRCA1 via its RING finger domain...
  30. Feki A, Jefford C, Berardi P, Wu J, Cartier L, Krause K, et al. BARD1 induces apoptosis by catalysing phosphorylation of p53 by DNA-damage response kinase. Oncogene. 2005;24:3726-36 pubmed
    The BRCA1-associated RING domain protein BARD1 acts with BRCA1 in double-strand break repair and ubiquitination...
  31. Cantor S, Bell D, Ganesan S, Kass E, Drapkin R, Grossman S, et al. BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function. Cell. 2001;105:149-60 pubmed
    ..Thus, it is conceivable that, like BRCA1, BACH1 is a target of germline cancer-inducing mutations. ..
  32. Li M, Yu X. Function of BRCA1 in the DNA damage response is mediated by ADP-ribosylation. Cancer Cell. 2013;23:693-704 pubmed publisher
    ..BRCA1 forms a Ring-domain heterodimer with BARD1, a major partner of BRCA1 that contains tandem BRCA1 C-terminus (BRCT) motifs...
  33. Yoon K, Kong S, Lee E, Cho J, Chang S, Lee E. A Novel Germline Mutation in BRCA1 Causes Exon 20 Skipping in a Korean Family with a History of Breast Cancer. J Breast Cancer. 2017;20:310-313 pubmed publisher
    ..Ectopically expressed mutant BRCA1 protein interacted with the BARD1 protein, but showed a reduced transcriptional function, as demonstrated by the expression of cyclin B1...