AZI2

Summary

Gene Symbol: AZI2
Description: 5-azacytidine induced 2
Alias: AZ2, NAP1, TILP, 5-azacytidine-induced protein 2, 5-azacytidine induced gene 2, NAK-associated protein 1, NF-kappa-B-activating kinase-associated protein 1
Species: human
Products:     AZI2

Top Publications

  1. Fujita F, Taniguchi Y, Kato T, Narita Y, Furuya A, Ogawa T, et al. Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling. Mol Cell Biol. 2003;23:7780-93 pubmed
    ..Here we identify NAP1 (for NAK-associated protein 1), a protein that interacts with NAK and its relative IKK epsilon (also known as IKKi)...
  2. Sasai M, Shingai M, Funami K, Yoneyama M, Fujita T, Matsumoto M, et al. NAK-associated protein 1 participates in both the TLR3 and the cytoplasmic pathways in type I IFN induction. J Immunol. 2006;177:8676-83 pubmed
    ..technology and human cell transfectants, we have revealed that knockdown of NAK-associated protein 1 (NAP1) leads to the down-regulation of IFN-beta promoter activation >24 h after poly(I:C) or virus (RSV and vesicular ..
  3. L M, Soliman M. The binding landscape of plasmepsin V and the implications for flap dynamics. Mol Biosyst. 2016;12:1457-67 pubmed publisher
    ..structure of PlmV is unique compared to other plasmepsins; it is stabilised internally by seven disulfide bonds, a NAP1 insert/fold is associated with the movement of the flap covering the active site and a highly conserved helix-turn-..
  4. Unterholzner L, Sumner R, Baran M, Ren H, Mansur D, Bourke N, et al. Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7. PLoS Pathog. 2011;7:e1002247 pubmed publisher
    ..Consistent with this notion, C6 immunoprecipitated with the TBK1 complex scaffold proteins TANK, SINTBAD and NAP1. C6 is expressed early during infection and is present in both nucleus and cytoplasm...
  5. Dudzicz S, Adamczak M, Wiecek A. Clostridium Difficile Infection in the Nephrology Ward. Kidney Blood Press Res. 2017;42:844-852 pubmed publisher
    ..This may be a consequence of excessive antibiotic use and spread of the hypervirulent epidemic BI/NAP1/027 strain of Clostridium difficile...
  6. Chen H, MacDonald A, Coffino P. Structural elements of antizymes 1 and 2 are required for proteasomal degradation of ornithine decarboxylase. J Biol Chem. 2002;277:45957-61 pubmed
    ..lysate, antizyme 1 (AZ1) accelerates proteasomal ornithine decarboxylase (ODC) degradation, but antizyme 2 (AZ2) does not...
  7. Pérez Topete S, Miranda Aquino T, Ayala Gaytán J. [Case series of Clostridium difficile NAP1/027/BI with novels treatments]. Rev Med Inst Mex Seguro Soc. 2017;55:654-659 pubmed
    ..They have recently reported outbreaks of C. difficile ribotype 027, which is characterized by a hypervirulent strain and high resistance to standard therapy...
  8. Tamez Torres K, Torres Gonzalez P, Leal Vega F, García Alderete A, López García N, Mendoza Aguilar R, et al. Impact of Clostridium difficile infection caused by the NAP1/RT027 strain on severity and recurrence during an outbreak and transition to endemicity in a Mexican tertiary care center. Int J Infect Dis. 2017;65:44-49 pubmed publisher
    ..To describe the clinical characteristics, outcomes, and factors associated with Clostridium difficile infection (CDI) due to ribotype 027 (RT027) and recurrence, including an outbreak period, with transition to endemicity...
  9. Liu K, Yu J, Zhao J, Zhou Y, Xiong N, Xu J, et al. AZI23'UTR Is a New SLC6A3 Downregulator Associated with an Epistatic Protection Against Substance Use Disorders. Mol Neurobiol. 2017;: pubmed publisher
    ..variant of the gene, intron 1 DNP1B sequence, as bait to screen and clone a new transcriptional activity, AZI23'UTR, for SLC6A3...
  10. von Eichel Streiber A, Paik W, Knight K, Gisch K, Nadjafi K, Decker C, et al. Induction of antitoxin responses in Clostridium-difficile-infected patients compared to healthy blood donors. Anaerobe. 2016;41:91-103 pubmed publisher
    ..Systemic responses to TcdB and mucosal responses to TcdA predominated. Among patients infected with the NAP1/027/BI strain, systemic IgG-anti-TcdB responses were particularly elevated...

Detail Information

Publications36

  1. Fujita F, Taniguchi Y, Kato T, Narita Y, Furuya A, Ogawa T, et al. Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling. Mol Cell Biol. 2003;23:7780-93 pubmed
    ..Here we identify NAP1 (for NAK-associated protein 1), a protein that interacts with NAK and its relative IKK epsilon (also known as IKKi)...
  2. Sasai M, Shingai M, Funami K, Yoneyama M, Fujita T, Matsumoto M, et al. NAK-associated protein 1 participates in both the TLR3 and the cytoplasmic pathways in type I IFN induction. J Immunol. 2006;177:8676-83 pubmed
    ..technology and human cell transfectants, we have revealed that knockdown of NAK-associated protein 1 (NAP1) leads to the down-regulation of IFN-beta promoter activation >24 h after poly(I:C) or virus (RSV and vesicular ..
  3. L M, Soliman M. The binding landscape of plasmepsin V and the implications for flap dynamics. Mol Biosyst. 2016;12:1457-67 pubmed publisher
    ..structure of PlmV is unique compared to other plasmepsins; it is stabilised internally by seven disulfide bonds, a NAP1 insert/fold is associated with the movement of the flap covering the active site and a highly conserved helix-turn-..
  4. Unterholzner L, Sumner R, Baran M, Ren H, Mansur D, Bourke N, et al. Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7. PLoS Pathog. 2011;7:e1002247 pubmed publisher
    ..Consistent with this notion, C6 immunoprecipitated with the TBK1 complex scaffold proteins TANK, SINTBAD and NAP1. C6 is expressed early during infection and is present in both nucleus and cytoplasm...
  5. Dudzicz S, Adamczak M, Wiecek A. Clostridium Difficile Infection in the Nephrology Ward. Kidney Blood Press Res. 2017;42:844-852 pubmed publisher
    ..This may be a consequence of excessive antibiotic use and spread of the hypervirulent epidemic BI/NAP1/027 strain of Clostridium difficile...
  6. Chen H, MacDonald A, Coffino P. Structural elements of antizymes 1 and 2 are required for proteasomal degradation of ornithine decarboxylase. J Biol Chem. 2002;277:45957-61 pubmed
    ..lysate, antizyme 1 (AZ1) accelerates proteasomal ornithine decarboxylase (ODC) degradation, but antizyme 2 (AZ2) does not...
  7. Pérez Topete S, Miranda Aquino T, Ayala Gaytán J. [Case series of Clostridium difficile NAP1/027/BI with novels treatments]. Rev Med Inst Mex Seguro Soc. 2017;55:654-659 pubmed
    ..They have recently reported outbreaks of C. difficile ribotype 027, which is characterized by a hypervirulent strain and high resistance to standard therapy...
  8. Tamez Torres K, Torres Gonzalez P, Leal Vega F, García Alderete A, López García N, Mendoza Aguilar R, et al. Impact of Clostridium difficile infection caused by the NAP1/RT027 strain on severity and recurrence during an outbreak and transition to endemicity in a Mexican tertiary care center. Int J Infect Dis. 2017;65:44-49 pubmed publisher
    ..To describe the clinical characteristics, outcomes, and factors associated with Clostridium difficile infection (CDI) due to ribotype 027 (RT027) and recurrence, including an outbreak period, with transition to endemicity...
  9. Liu K, Yu J, Zhao J, Zhou Y, Xiong N, Xu J, et al. AZI23'UTR Is a New SLC6A3 Downregulator Associated with an Epistatic Protection Against Substance Use Disorders. Mol Neurobiol. 2017;: pubmed publisher
    ..variant of the gene, intron 1 DNP1B sequence, as bait to screen and clone a new transcriptional activity, AZI23'UTR, for SLC6A3...
  10. von Eichel Streiber A, Paik W, Knight K, Gisch K, Nadjafi K, Decker C, et al. Induction of antitoxin responses in Clostridium-difficile-infected patients compared to healthy blood donors. Anaerobe. 2016;41:91-103 pubmed publisher
    ..Systemic responses to TcdB and mucosal responses to TcdA predominated. Among patients infected with the NAP1/027/BI strain, systemic IgG-anti-TcdB responses were particularly elevated...
  11. Sasai M, Oshiumi H, Matsumoto M, Inoue N, Fujita F, Nakanishi M, et al. Cutting Edge: NF-kappaB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN regulatory factor 3 activation. J Immunol. 2005;174:27-30 pubmed
    ..The results are: 1) the TANK family protein NAK-associated protein 1 (NAP1), but not TANK, coprecipitates withTICAM-1; 2) NAP1 overexpression markedly enhances TBK1-mediated IFN-beta ..
  12. Moraes L, Zanchin N, Cerutti J. ABI3, a component of the WAVE2 complex, is potentially regulated by PI3K/AKT pathway. Oncotarget. 2017;8:67769-67781 pubmed publisher
    ..37 ABI3 partners, including several components of the canonical WAVE regulatory complex (WRC) such as WAVE2/CYF1P1/NAP1, suggesting that ABI3 function might be regulated through WRC...
  13. Mazo G, Soplop N, Wang W, Uryu K, Tsou M. Spatial Control of Primary Ciliogenesis by Subdistal Appendages Alters Sensation-Associated Properties of Cilia. Dev Cell. 2016;39:424-437 pubmed publisher
    ..we found that a group of sDAP components localize to the centriole proximal end through the cohesion factor C-Nap1 and that sDAP function redundantly with C-Nap1 for submerged cilia maintenance...
  14. Antosz W, Pfab A, Ehrnsberger H, Holzinger P, Köllen K, Mortensen S, et al. The Composition of the Arabidopsis RNA Polymerase II Transcript Elongation Complex Reveals the Interplay between Elongation and mRNA Processing Factors. Plant Cell. 2017;29:854-870 pubmed publisher
    ..Additionally, NAP1 histone chaperones, ATP-dependent chromatin remodeling factors, and some histone-modifying enzymes including ..
  15. Hamp J, Löwer A, Dottermusch Heidel C, Beck L, Moussian B, Flötenmeyer M, et al. Drosophila Kette coordinates myoblast junction dissolution and the ratio of Scar-to-WASp during myoblast fusion. J Cell Sci. 2016;129:3426-36 pubmed publisher
    ..Severe defects in myoblast fusion are caused by the loss of Kette (a homolog of Nap1 and Hem-2, also known as NCKAP1 and NCKAP1L, respectively), a member of the regulatory complex formed by Scar or ..
  16. Prasad N, Labaze G, Kopacz J, Chwa S, Platis D, Pan C, et al. Asymptomatic rectal colonization with carbapenem-resistant Enterobacteriaceae and Clostridium difficile among residents of a long-term care facility in New York City. Am J Infect Control. 2016;44:525-32 pubmed publisher
    ..This study was undertaken to determine prevalence of asymptomatic rectal colonization with Clostridium difficile (and proportion of 027/NAP1/BI ribotype) or carbapenem-resistant Enterobacteriaceae (CRE) in an LTCF population.
  17. Lee Y, Kim D, Ryu J, Zhang Y, Kim S, Kim Y, et al. Phosphorylation of CYFIP2, a component of the WAVE-regulatory complex, regulates dendritic spine density and neurite outgrowth in cultured hippocampal neurons potentially by affecting the complex assembly. Neuroreport. 2017;28:749-754 pubmed publisher
    ..the crystal structure of WRC and found that T1067 phosphorylation could weaken the interaction between CYFIP2 and Nap1 by inducing conformational changes of CYFIP2 α-helical bundles...
  18. Reddy D, Bhattacharya S, Jani V, Sonavane U, Joshi R, Gupta S. Biochemical and Biophysical Characterisation of Higher Oligomeric Structure of Rat Nucleosome Assembly Protein 1. Protein J. 2017;: pubmed publisher
    Nucleosome assembly protein 1 (NAP1) is a histone chaperone that exchanges histone H2A-H2B dimer from chromatin templates. Studies with yeast NAP1 (yNAP1) have revealed its existence as multiple oligomeric species in solution...
  19. Plessis P, Ojumu T, Petrik L. Waste Minimization Protocols for the Process of Synthesizing Zeolites from South African Coal Fly Ash. Materials (Basel). 2013;6:1688-1703 pubmed publisher
    ..This result could be used to establish a basis for legal and environmental aspects involved in the commission of a full-scale plant synthesizing zeolites NaP1 and analcime.
  20. Tanaka T, Hozumi Y, Iino M, Goto K. NAP1L1 regulates NF-κB signaling pathway acting on anti-apoptotic Mcl-1 gene expression. Biochim Biophys Acta. 2017;1864:1759-1768 pubmed publisher
    ..Of those, the human NAP1-like protein (NAP1L) family functions in the transport, assembly/disassembly of nucleosome core particles...
  21. Funami K, Sasai M, Ohba Y, Oshiumi H, Seya T, Matsumoto M. Spatiotemporal mobilization of Toll/IL-1 receptor domain-containing adaptor molecule-1 in response to dsRNA. J Immunol. 2007;179:6867-72 pubmed
    ..In addition, NF-kappaB-activating kinase-associated protein 1 (NAP1), a downstream molecule linking TICAM-1 and the IRF-3-activating kinase TBK1 (TANK-binding kinase 1), was also ..
  22. Bauer K, Johnston J, Wenzler E, Goff D, Cook C, Balada Llasat J, et al. Impact of the NAP-1 strain on disease severity, mortality, and recurrence of healthcare-associated Clostridium difficile infection. Anaerobe. 2017;48:1-6 pubmed publisher
    Studies are conflicting regarding the association of the North American pulsed-field gel electrophoresis type 1 (NAP1) strain in Clostridium difficile infection (CDI) and outcomes...
  23. Lee J, Lake R, Kirk J, Bohr V, Fan H, Hohng S. NAP1L1 accelerates activation and decreases pausing to enhance nucleosome remodeling by CSB. Nucleic Acids Res. 2017;45:4696-4707 pubmed publisher
    ..CSB alone remodels nucleosomes ∼10-fold slower than the ACF remodeling complex. Strikingly, NAP1-like histone chaperones interact with CSB and greatly enhance CSB-mediated chromatin remodeling...
  24. Tkhawkho L, Nitzan O, Pastukh N, Brodsky D, Jackson K, Peretz A. Antimicrobial susceptibility of Clostridium difficile isolates in Israel. J Glob Antimicrob Resist. 2017;10:161-164 pubmed publisher
    ..difficile infection. Specimens were screened for BI/NAP1/027 ribotype, cultured, and sensitivity tests were performed for vancomycin, metronidazole, moxifloxacin, and ..
  25. Zhao W, Wang L, Zhang M, Wang P, Yuan C, Qi J, et al. Tripartite motif-containing protein 38 negatively regulates TLR3/4- and RIG-I-mediated IFN-β production and antiviral response by targeting NAP1. J Immunol. 2012;188:5311-8 pubmed publisher
    ..colocalization experiments demonstrated that TRIM38 interacted with NF-κB-activating kinase-associated protein 1 (NAP1), which is required for TLR-induced IFN regulatory factor 3 activation and IFN-β production...
  26. Le Breton M, Meyniel Schicklin L, Deloire A, Coutard B, Canard B, de Lamballerie X, et al. Flavivirus NS3 and NS5 proteins interaction network: a high-throughput yeast two-hybrid screen. BMC Microbiol. 2011;11:234 pubmed publisher
    ..Our virus-host interaction map provides a basis to unravel fundamental processes about flavivirus subversion of the host replication machinery and/or immune defence strategy. ..
  27. Fang R, Jiang Q, Zhou X, Wang C, Guan Y, Tao J, et al. MAVS activates TBK1 and IKKε through TRAFs in NEMO dependent and independent manner. PLoS Pathog. 2017;13:e1006720 pubmed publisher
    ..and IKKα/β, is unclear, although previous work suggests the involvement of NEMO or TBK1-binding proteins TANK, NAP1, and SINTBAD...
  28. Namburi P, Ratnapriya R, Khateb S, Lazar C, Kinarty Y, Obolensky A, et al. Bi-allelic Truncating Mutations in CEP78, Encoding Centrosomal Protein 78, Cause Cone-Rod Degeneration with Sensorineural Hearing Loss. Am J Hum Genet. 2016;99:777-784 pubmed publisher
    ..CEP78 was reported previously to interact with c-nap1, encoded by CEP250 that we reported earlier to cause atypical Usher syndrome...
  29. Dronamraju R, Ramachandran S, Jha D, Adams A, DiFiore J, Parra M, et al. Redundant Functions for Nap1 and Chz1 in H2A.Z Deposition. Sci Rep. 2017;7:10791 pubmed publisher
    ..Z is deposited by the SWR-C complex, which relies on several histone chaperones including Nap1 and Chz1 to deliver H2A.Z-H2B dimers to SWR-C. However, the mechanisms by which Nap1 and Chz1 cooperate to bind H2A...
  30. Seo S, Solivan Timpe F, Roos B, Robin A, Stone E, Kwon Y, et al. Identification of proteins that interact with TANK binding kinase 1 and testing for mutations associated with glaucoma. Curr Eye Res. 2013;38:310-5 pubmed publisher
    ..TAP studies show that three proteins expressed in HEK-293T cells (NAP1, TANK and TBKBP1) interact with TBK1...
  31. Fan Y, Li Y, Wu D, Li C, Kong H. Application of zeolite/hydrous zirconia composite as a novel sediment capping material to immobilize phosphorus. Water Res. 2017;123:1-11 pubmed publisher
    ..In the ZHZ, NaP1 zeolite was covered with hydrous zirconia, which existed as an amorphous phase...
  32. Lee J, Lee T. Single-Molecule Investigations on Histone H2A-H2B Dynamics in the Nucleosome. Biochemistry. 2017;56:977-985 pubmed publisher
    ..the early kinetics of H2A-H2B dimer dissociation triggered by high salt concentration and by histone chaperone Nap1. The results reveal that dimer displacement requires DNA unwrapping in the vast majority of the nucleosomes in the ..
  33. Miyagawa J, Muguruma M, Aoto H, Suetake I, Nakamura M, Tajima S. Isolation of the novel cDNA of a gene of which expression is induced by a demethylating stimulus. Gene. 1999;240:289-95 pubmed
    We have isolated a novel cDNA clone, named AZ2, from a cDNA library of mRNA prepared from C3H10T1/2 cells that had been transiently exposed to 5-azacytidine, a potent inhibitor of DNA methyltransferase...
  34. Cejas D, Ríos Osorio N, Quiros R, Sadorin R, Berger M, Gutkind G, et al. Detection and molecular characterization of Clostridium difficile ST 1 in Buenos Aires, Argentina. Anaerobe. 2017;49:14-17 pubmed publisher
    ..Two/4 cdtA/B positives isolates corresponded to ST 1 resembling BI/NAP1/027/ST 1 strain, while the others corresponded to ST 226 and ST 377.
  35. Giancola S, Williams R, Gentry C. Prevalence of the Clostridium difficile BI/NAP1/027 strain across the United States Veterans Health Administration. Clin Microbiol Infect. 2017;: pubmed publisher
    ..of Clostridium difficile infection (CDI) are thought to result partly from the emergence of the hypervirulent BI/NAP1/027 strain. Limited recent data are available on the prevalence of BI/NAP1/027 in the United States (US)...