ATP citrate lyase

Summary

Gene Symbol: ATP citrate lyase
Description: ATP citrate lyase
Alias: ACL, ATPCL, CLATP, ATP-citrate synthase, ATP-citrate (pro-S-)-lyase, citrate cleavage enzyme
Species: human
Products:     ATP citrate lyase

Top Publications

  1. Zaidi N, Royaux I, Swinnen J, Smans K. ATP citrate lyase knockdown induces growth arrest and apoptosis through different cell- and environment-dependent mechanisms. Mol Cancer Ther. 2012;11:1925-35 pubmed publisher
    b>ATP citrate lyase (ACLY) is a cytosolic enzyme that catalyzes generation of acetyl-CoA, which is a vital building block for fatty acid, cholesterol, and isoprenoid biosynthesis...
  2. Migita T, Narita T, Nomura K, Miyagi E, Inazuka F, Matsuura M, et al. ATP citrate lyase: activation and therapeutic implications in non-small cell lung cancer. Cancer Res. 2008;68:8547-54 pubmed publisher
    Enhanced glucose and lipid metabolism is one of the most common properties of malignant cells. ATP citrate lyase (ACLY) is a key enzyme of de novo fatty acid synthesis responsible for generating cytosolic acetyl-CoA and oxaloacetate...
  3. Wellen K, Hatzivassiliou G, Sachdeva U, Bui T, Cross J, Thompson C. ATP-citrate lyase links cellular metabolism to histone acetylation. Science. 2009;324:1076-80 pubmed publisher
    ..have shown that histone acetylation in mammalian cells is dependent on adenosine triphosphate (ATP)-citrate lyase (ACL), the enzyme that converts glucose-derived citrate into acetyl-CoA...
  4. Beckner M, Fellows Mayle W, Zhang Z, Agostino N, Kant J, Day B, et al. Identification of ATP citrate lyase as a positive regulator of glycolytic function in glioblastomas. Int J Cancer. 2010;126:2282-95 pubmed publisher
    ..The enzyme that breaks down cytosolic citric acid is ATP citrate lyase (ACLY)...
  5. Oaks Z, Winans T, Caza T, Fernandez D, Liu Y, Landas S, et al. Mitochondrial Dysfunction in the Liver and Antiphospholipid Antibody Production Precede Disease Onset and Respond to Rapamycin in Lupus-Prone Mice. Arthritis Rheumatol. 2016;68:2728-2739 pubmed publisher
    ..Anticardiolipin (aCL) and anti-?2 -glycoprotein I (anti-?2 GPI) autoantibodies were measured by enzyme-linked ..
  6. Han J, Li L, Wang D, Ma H. (-)-Hydroxycitric acid reduced fat deposition via regulating lipid metabolism-related gene expression in broiler chickens. Lipids Health Dis. 2016;15:37 pubmed publisher
    ..Graphical abstract Mechanism of (-)-HCA effect on hepatic lipids metabolism. ..
  7. Cleveland B, Manor M. Effects of phytoestrogens on growth-related and lipogenic genes in rainbow trout (Oncorhynchus mykiss). Comp Biochem Physiol C Toxicol Pharmacol. 2015;170:28-37 pubmed publisher
    ..These data indicate that genistein and daidzein affect expression of genes in rainbow trout that regulate physiological mechanisms central to growth and nutrient retention. ..
  8. Yadav S, Pandey A, Kumar L, Devi A, Kushwaha B, Vishvkarma R, et al. The thermo-sensitive gene expression signatures of spermatogenesis. Reprod Biol Endocrinol. 2018;16:56 pubmed publisher
  9. Casey E, Reese M, Okafor E, Chun D, Gagnon C, Nigl F, et al. Influence of Menstrual Cycle and Oral Contraceptive Phase on Spinal Excitability. PM R. 2016;8:860-8 pubmed publisher
    ..between the genders, with females more likely to experience conditions such as anterior cruciate ligament (ACL) injuries than males in the same sports. Emerging evidence suggests a significant hormonal contribution...

More Information

Publications145 found, 100 shown here

  1. Plubell D, Wilmarth P, Zhao Y, Fenton A, Minnier J, Reddy A, et al. Extended Multiplexing of Tandem Mass Tags (TMT) Labeling Reveals Age and High Fat Diet Specific Proteome Changes in Mouse Epididymal Adipose Tissue. Mol Cell Proteomics. 2017;16:873-890 pubmed publisher
    ..Data are available via ProteomeXchange with identifier PXD005953. ..
  2. Mondal N, Roychoudhury S, Mukherjee S, Siddique S, Banerjee M, Slaughter M, et al. Increased risk of cardiovascular disease in premenopausal female ragpickers of Eastern India: involvement of inflammation, oxidative stress, and platelet hyperactivity. Mol Cell Biochem. 2016;419:193-203 pubmed publisher
    ..NAP-2), platelet and plasma serotonin, oxidized low-density lipoprotein (oxLDL), and anticardiolipin antibodies (aCL) in plasma were measured by ELISA...
  3. DiSilvestro K, Santoro A, Tjoumakaris F, Levicoff E, Freedman K. When Can I Drive After Orthopaedic Surgery? A Systematic Review. Clin Orthop Relat Res. 2016;474:2557-2570 pubmed
    ..suggested patients reached presurgical norms 4 weeks after right-sided procedures such as TKA, THA, and ACL reconstruction and approximately 1 week after left-sided TKA and THA...
  4. Secrist E, Freedman K, Ciccotti M, Mazur D, Hammoud S. Pain Management After Outpatient Anterior Cruciate Ligament Reconstruction: A Systematic Review of Randomized Controlled Trials. Am J Sports Med. 2016;44:2435-47 pubmed publisher
    Effective pain management after anterior cruciate ligament (ACL) reconstruction improves patient satisfaction and function...
  5. Dunn K, Lam K, Valovich McLeod T. Early Operative Versus Delayed or Nonoperative Treatment of Anterior Cruciate Ligament Injuries in Pediatric Patients. J Athl Train. 2016;51:425-7 pubmed publisher
    ..Clinical Questions: In pediatric patients, does early operative treatment of an anterior cruciate ligament (ACL) injury result in decreased knee instability compared with delayed or nonoperative treatment? This review focused ..
  6. Chen L, Lotz M, Terkeltaub R, Liu Bryan R. Modulation of matrix metabolism by ATP-citrate lyase in articular chondrocytes. J Biol Chem. 2018;293:12259-12270 pubmed publisher
    ..Pharmacologic ACLY inhibition in OA chondrocytes globally reverses these changes and stimulates matrix gene expression and AMPK activation, supporting translational investigation in OA. ..
  7. Konopka J, DeBaun M, Chang W, Dragoo J. The Intracellular Effect of Relaxin on Female Anterior Cruciate Ligament Cells. Am J Sports Med. 2016;44:2384-92 pubmed publisher
    ..0 pg/mL have been shown to have more than 4 times increased risk for anterior cruciate ligament (ACL) tears. However, the intracellular effect of relaxin on ACL cells has not been elucidated...
  8. Ali M, Dash P, Nasrin M. Study of sedative activity of different extracts of Kaempferia galanga in Swiss albino mice. BMC Complement Altern Med. 2015;15:158 pubmed publisher
    ..as petroleum ether fraction (PEF), chloroform fraction (CHF), methanol fraction (MEF) and acetone extract of leaf (ACL) were examined for sedative activity...
  9. Ames P, Merashli M, Chis Ster I, D Andrea G, Iannaccone L, Marottoli V, et al. Survival in primary antiphospholipid syndrome. A single-centre cohort study. Thromb Haemost. 2016;115:1200-8 pubmed publisher
    ..It was the study objective to evaluate the impact of baseline lupus anticoagulant assays, IgG anticardiolipin (aCL), plasma fibrinogen (FNG) and von Willebrand factor (VWF), platelets (PLT) and of genetic polymorphisms of ..
  10. Larsson S, Struglics A, Lohmander L, Frobell R. Surgical reconstruction of ruptured anterior cruciate ligament prolongs trauma-induced increase of inflammatory cytokines in synovial fluid: an exploratory analysis in the KANON trial. Osteoarthritis Cartilage. 2017;25:1443-1451 pubmed publisher
    Prospectively monitor how treatment of acutely ruptured anterior cruciate ligament (ACL) affects biomarkers of inflammation and proteolytic degradation over 5 years...
  11. Chmielewski T, George S, Tillman S, Moser M, Lentz T, Indelicato P, et al. Low- Versus High-Intensity Plyometric Exercise During Rehabilitation After Anterior Cruciate Ligament Reconstruction. Am J Sports Med. 2016;44:609-17 pubmed publisher
    Plyometric exercise is used during rehabilitation after anterior cruciate ligament (ACL) reconstruction to facilitate the return to sports participation...
  12. Papalardo E, Romay Penabad Z, Willis R, Christadoss P, Carrera Marin A, Reyes Maldonado E, et al. Major Histocompatibility Complex Class II Alleles Influence Induction of Pathogenic Antiphospholipid Antibodies in a Mouse Model of Thrombosis. Arthritis Rheumatol. 2017;69:2052-2061 pubmed publisher
    ..in carotid and peritoneal macrophages, and serum levels of tumor necrosis factor (TNF), IgG anticardiolipin (aCL), antibodies, and anti-OVA antibodies were determined...
  13. Wang F, Zhou Z, Ren X, Wang Y, Yang R, Luo J, et al. Effect of Ganoderma lucidum spores intervention on glucose and lipid metabolism gene expression profiles in type 2 diabetic rats. Lipids Health Dis. 2015;14:49 pubmed publisher
    ..Meanwhile, GLSP treatment was also associated with the improvement of blood lipid compositions through the regulation of cholesterol homeostasis in the type 2 diabetic rats. ..
  14. Flees J, Rajaei Sharifabadi H, GREENE E, Beer L, Hargis B, Ellestad L, et al. Effect of Morinda citrifolia (Noni)-Enriched Diet on Hepatic Heat Shock Protein and Lipid Metabolism-Related Genes in Heat Stressed Broiler Chickens. Front Physiol. 2017;8:919 pubmed publisher
    ..HSP90 as well as key lipogenic proteins (fatty acid synthase, FASN; acetyl co-A carboxylase alpha, ACC? and ATP citrate lyase, ACLY)...
  15. Zou Y, Chen L, Ye Y, Yang G, Mao Z, Liu D, et al. Attenuated synovial fluid ghrelin levels are linked with cartilage damage, meniscus injury, and clinical symptoms in patients with knee anterior cruciate ligament deficiency. Discov Med. 2016;22:325-335 pubmed
    The meniscus injury and post-traumatic knee osteoarthritis (PTOA) following anterior cruciate ligament (ACL) lesions often cause great burdens to patients...
  16. Chaturvedi S, McCrae K. Diagnosis and management of the antiphospholipid syndrome. Blood Rev. 2017;31:406-417 pubmed publisher
    ..of a lupus anticoagulant, which prolongs phospholipid-dependent anticoagulation tests, and/or anticardiolipin (aCL) and anti-?2-glycoprotein-1 (?2GPI) antibodies. APLA are primarily directed toward phospholipid binding proteins...
  17. Li J, Hu X, Zhang Q, Cao H, Liu C, Wang J, et al. Activated protein C resistance associated with lupus anticoagulants is a high risk in acute mesenteric venous thrombosis. J Vasc Surg Venous Lymphat Disord. 2014;2:155-9 pubmed publisher
    ..000), but aCLs do not have an increased predisposition to APC resistance (P = .85). APC resistance associated with LAs is a high risk in AMVT. The way aCL may affect the process of AMVT is not the same as with LA.
  18. Kuete V, Tchinda C, Mambe F, Beng V, Efferth T. Cytotoxicity of methanol extracts of 10 Cameroonian medicinal plants towards multi-factorial drug-resistant cancer cell lines. BMC Complement Altern Med. 2016;16:267 pubmed publisher
    ..were from two plants: Albizia adianthifolia roots (AAR) and bark (AAB) as well as Alchornea cordifolia leaves (ACL) and bark (ACB) had respective IC50 values of 0.98 ?g/mL, 1.45 ?g/mL, 8.02 ?g/mL and 12...
  19. Akelman M, Fadale P, Hulstyn M, Shalvoy R, Garcia A, Chin K, et al. Effect of Matching or Overconstraining Knee Laxity During Anterior Cruciate Ligament Reconstruction on Knee Osteoarthritis and Clinical Outcomes: A Randomized Controlled Trial With 84-Month Follow-up. Am J Sports Med. 2016;44:1660-70 pubmed publisher
    The "initial graft tension" applied at the time of graft fixation during anterior cruciate ligament (ACL) reconstruction surgery modulates joint contact mechanics, which in turn may promote posttraumatic osteoarthritis (OA)...
  20. Becarevic M, Mirković D, Ignjatovic S. Double positivity of the IgG isotype of both anticardiolipin and anti-?2gpI antibodies is associated with the highest number of vascular impairment parameters in patients with primary antiphospholipid syndrome: preliminary data. Clin Rheumatol. 2016;35:2947-2954 pubmed
    ..Double positivity for both isotypes of anticardiolipin (aCL) Abs (IgG + IgM) was associated with the increased apoB levels...
  21. Xu J, Yin L, Xu Y, Li Y, Zalzala M, Cheng G, et al. Hepatic carboxylesterase 1 is induced by glucose and regulates postprandial glucose levels. PLoS ONE. 2014;9:e109663 pubmed publisher
    ..Knockdown of ATP-citrate lyase (ACL), an enzyme that regulates histone acetylation, abolished glucose-mediated histone acetylation in the CES1 ..
  22. Paessler H, Mastrokalos D. Anterior cruciate ligament reconstruction using semitendinosus and gracilis tendons, bone patellar tendon, or quadriceps tendon-graft with press-fit fixation without hardware. A new and innovative procedure. Orthop Clin North Am. 2003;34:49-64 pubmed
    BONE--PATELLAR TENDON: The "no hardware" technique for ACL reconstruction is a new method that offers many advantages and is straightforward to perform...
  23. Gajic Veljic M, Bonaci Nikolic B, Lekić B, Skiljevic D, Ciric J, Zoric S, et al. Importance of low serum DNase I activity and polyspecific anti-neutrophil cytoplasmic antibodies in propylthiouracil-induced lupus-like syndrome. Rheumatology (Oxford). 2015;54:2061-70 pubmed publisher
    ..bactericidal/permeability-increasing protein), anti-dsDNA, anti-ENA, anti-nucleosome, anti-histone, anti-C1q, anti-aCL, complement components, cryoglobulins and serum DNase I activity...
  24. Hoxha A, Banzato A, Ruffatti A, Pengo V. Detection of lupus anticoagulant in the era of direct oral anticoagulants. Autoimmun Rev. 2017;16:173-178 pubmed publisher
    ..The presence of LAC associated with anticardiolipin (aCL) and anti-?2 glycoprotein I (anti-?2GPI) antibodies is strongly associated with thrombosis and pregnancy morbidity...
  25. Tian S, Wang Y, Wang B, Liu L, Ha C, Li Q, et al. Anatomic Double-Bundle Anterior Cruciate Ligament Reconstruction With a Hamstring Tendon Autograft and Fresh-Frozen Allograft: A Prospective, Randomized, and Controlled Study. Arthroscopy. 2016;32:2521-2531 pubmed publisher
    To compare the clinical outcome of anatomic double-bundle (DB) anterior cruciate ligament (ACL) reconstruction with a hamstring tendon autograft versus fresh-frozen allograft...
  26. Taketomi S, Inui H, Tahara K, Shirakawa N, Tanaka S, Nakagawa T. Effects of initial graft tension on femoral tunnel widening after anatomic anterior cruciate ligament reconstruction using a bone-patellar tendon-bone graft. Arch Orthop Trauma Surg. 2017;137:1285-1291 pubmed publisher
    The effects of initial graft tension upon tunnel widening (TW) following anatomic anterior cruciate ligament (ACL) reconstruction have not been elucidated...
  27. Boyle M, Vovos T, Walker C, Stabile K, Roth J, Garrett W. Does adjustable-loop femoral cortical suspension loosen after anterior cruciate ligament reconstruction? A retrospective comparative study. Knee. 2015;22:304-8 pubmed publisher
    ..research has suggested that adjustable-loop graft suspension constructs in anterior cruciate ligament (ACL) reconstruction may loosen after deployment...
  28. Çelebi M, Başkak B, Saka T, Devrimci Özgüven H, Ülkar B, Atalar E. Psychiatric and functional evaluation of professional athletes following anterior cruciate ligament reconstruction. Acta Orthop Traumatol Turc. 2015;49:492-6 pubmed publisher
    ..evaluate early phase depression and anxiety in the proffessional athletes who underwent anterior cruciate ligament (ACL) reconstruction and compare them with the functional improvement of knee...
  29. Rawal A, Sibal A, Saraswat H, Khan S. Topologically controlled tensile behaviour of braided prostheses for anterior cruciate ligaments. J Mech Behav Biomed Mater. 2016;57:359-64 pubmed publisher
    Anterior cruciate ligament (ACL) is one of the most susceptible ligaments of the knee that can suffer injury...
  30. Ahmad S, Meyer J, Krismer A, Ahmad S, Evangelopoulos D, Hoppe S, et al. Outcome measures in clinical ACL studies: an analysis of highly cited level I trials. Knee Surg Sports Traumatol Arthrosc. 2017;25:1517-1527 pubmed publisher
    Clinical research in the area of anterior cruciate ligament (ACL) injury has shown substantial growth during the last decade...
  31. Pütter K, van Deenen N, Unland K, Prüfer D, Schulze Gronover C. Isoprenoid biosynthesis in dandelion latex is enhanced by the overexpression of three key enzymes involved in the mevalonate pathway. BMC Plant Biol. 2017;17:88 pubmed publisher
    ..However, two enzymes acting upstream of HMGR have not been characterized in dandelion latex: ATP citrate lyase (ACL), which provides the acetyl-CoA utilized in the MVA pathway, and acetoacetyl-CoA thiolase (AACT), which ..
  32. Häberli J, Jaberg L, Bieri K, Eggli S, Henle P. Reinterventions after dynamic intraligamentary stabilization in primary anterior cruciate ligament repair. Knee. 2018;25:271-278 pubmed publisher
    ..analysis of the frequency and cause of secondary interventions subsequent to primary anterior cruciate ligament (ACL) repair with dynamic intraligamentary stabilization (DIS)...
  33. Akoto R, Müller Hübenthal J, Balke M, Albers M, Bouillon B, Helm P, et al. Press-fit fixation using autologous bone in the tibial canal causes less enlargement of bone tunnel diameter in ACL reconstruction--a CT scan analysis three months postoperatively. BMC Musculoskelet Disord. 2015;16:200 pubmed publisher
    Bone tunnel enlargement is a phenomenon present in all anterior cruciate ligament (ACL)- reconstruction techniques...
  34. Hoffelner T, Pichler I, Moroder P, Osti M, Hudelmaier M, Wirth W, et al. Segmentation of the lateral femoral notch sign with MRI using a new measurement technique. BMC Musculoskelet Disord. 2015;16:217 pubmed publisher
    ..determine the dimension and location of the impaction fracture on the lateral femoral condyle in patients with an ACL rupture...
  35. Watters T, Zhen Y, Martin J, Levy D, Jennings J, Dennis D. Total Knee Arthroplasty After Anterior Cruciate Ligament Reconstruction: Not Just a Routine Primary Arthroplasty. J Bone Joint Surg Am. 2017;99:185-189 pubmed publisher
    ..the success of restoring joint stability and improving early functional outcomes after anterior cruciate ligament (ACL) reconstruction, the long-term risk of developing symptomatic osteoarthritis requiring total knee arthroplasty is ..
  36. Kosy J, Schranz P, Patel A, Anaspure R, Mandalia V. The magnetic resonance imaging appearance of the anterolateral ligament of the knee in association with anterior cruciate rupture. Skeletal Radiol. 2017;46:1193-1200 pubmed publisher
    ..However, the appearance of this structure and injury, in the presence of anterior cruciate ligament (ACL) injury, is less well defined. We studied the incidence of injury to the ALL and the pattern of this injury on MRI...
  37. Xie G, Dong S, Huangfu X, Zhao J. [EXPRESSIONS OF LIGAMENT REMODELING RELATED GENES IN RABBIT MODEL OF ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION WITH PRESERVING TIBIAL RESIDUAL FIBERS]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2016;30:15-20 pubmed
    ..residual fibers on the expressions of ligament remodeling related genes in rabbit anterior cruciate ligament (ACL) reconstruction model...
  38. Haber D, Brook E, Whitlock K, Matzkin E. Predicting Quadrupled Graft Length and Diameter Using Single-Strand Tendon Dimensions in All-Inside Anterior Cruciate Ligament Reconstruction. Arthroscopy. 2018;34:243-250 pubmed publisher
    ..semitendinosus graft measurements were recorded for consecutive all-inside anterior cruciate ligament (ACL) reconstructions from 2013 to 2016 and retrospectively reviewed...
  39. Makhni E, Padaki A, Petridis P, Steinhaus M, Ahmad C, Cole B, et al. High Variability in Outcome Reporting Patterns in High-Impact ACL Literature. J Bone Joint Surg Am. 2015;97:1529-42 pubmed publisher
    b>ACL (anterior cruciate ligament) reconstruction is one of the most commonly performed and studied procedures in modern sports medicine...
  40. Osti L, Buda M, Osti R, Massari L, Maffulli N. Preoperative Planning for ACL Revision Surgery. Sports Med Arthrosc Rev. 2017;25:19-29 pubmed publisher
    The number of patients undergoing revision surgery following failure of anterior cruciate ligament (ACL) reconstruction has increased over the recent past, following the overall increased number of primary ACL reconstruction performed...
  41. Ran J, Hu Y, Le H, Chen Y, Zheng Z, Chen X, et al. Ectopic tissue engineered ligament with silk collagen scaffold for ACL regeneration: A preliminary study. Acta Biomater. 2017;53:307-317 pubmed publisher
    Anterior cruciate ligament (ACL) reconstruction remains a formidable clinical challenge because of the lack of vascularization and adequate cell numbers in the joint cavity...
  42. Sebastiani G, Iuliano A, Cantarini L, Galeazzi M. Genetic aspects of the antiphospholipid syndrome: An update. Autoimmun Rev. 2016;15:433-9 pubmed publisher
    ..Furthermore, it appears that lupus anticoagulant (LA) and anticardiolipin (aCL) antibodies are both associated with the same HLA antigens...
  43. Li Y, Li R, Chen W, Chen G. Vitamin A status and its metabolism contribute to the regulation of hepatic genes during the cycle of fasting and refeeding in rats. J Nutr Biochem. 2016;30:33-43 pubmed publisher
    ..The ACL and FAS protein levels only dropped in VAS-Fasted rats and increased in VAS-Refed-VAS rats...
  44. Hiemstra L, Kerslake S, Heard M, Buchko G, Lafave M. Outcomes of surgical stabilization in patients with combined ACL deficiency and patellofemoral instability - A case series. Knee. 2016;23:1106-1111 pubmed publisher
    ..disease-specific quality of life, and the objective clinical and functional outcomes of patients with symptomatic ACL deficiency and patellofemoral instability following surgical stabilization of both ligaments...
  45. Zhu L, Li C, Liu N, Yang X, Jia R, Mu R, et al. Diagnostic value of antibodies to phosphatidylserine/prothrombin complex for antiphospholipid syndrome in Chinese patients. Clin Rheumatol. 2017;36:401-406 pubmed publisher
    ..952, 95% CI 7.132-35.678; P < 0.001). The frequency of aPS/PT was 56.9% in anti-cardiolipid antibody (aCL)-negative, 60.5% anti-?2 glycoprotein I antibody (a?2GPI)-negative, and 50...
  46. Kaiser J, Vignos M, Kijowski R, Baer G, Thelen D. Effect of Loading on In Vivo Tibiofemoral and Patellofemoral Kinematics of Healthy and ACL-Reconstructed Knees. Am J Sports Med. 2017;45:3272-3279 pubmed publisher
  47. Cavaignac E, Marot V, Faruch M, Reina N, Murgier J, Accadbled F, et al. Hamstring Graft Incorporation According to the Length of the Graft Inside Tunnels. Am J Sports Med. 2017;:363546517733472 pubmed publisher
    Anterior cruciate ligament (ACL) reconstruction with a quadrupled semitendinosus (ST4) graft is an evolution of the standard technique with 2 hamstring tendons (semitendinosus + gracilis [STG])...
  48. Wu H, Ma C, Xiong Y, Yan S, Wu L, Wu W. Y-reconstruction could be better for ACL reconstruction in knee hyperextension versus double-bundle double-tunnel technique: a retrospective comparative study of 56 patients. Arch Orthop Trauma Surg. 2018;138:827-834 pubmed publisher
    ..To compare the clinical outcomes of double-bundle (DB) single-tibial tunnel technique and double-tunnel technique for ACL reconstruction in patients with knee hyperextension...
  49. Schurz M, Tiefenboeck T, Winnisch M, Syré S, Plachel F, Steiner G, et al. Clinical and Functional Outcome of All-Inside Anterior Cruciate Ligament Reconstruction at a Minimum of 2 Years' Follow-up. Arthroscopy. 2016;32:332-7 pubmed publisher
    To evaluate the clinical and functional outcomes for anatomic anterior cruciate ligament (ACL) reconstruction using the all-inside technique with a minimum follow-up of 24 months...
  50. Yu Y, Li Y, Wang G, Jia D, Gao H, Wang K, et al. [EFFECTIVENESSES OF SINGLE-BUNDLE AND DOUBLE-BUNDLE ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION BY TWO METHODS]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2015;29:1208-13 pubmed
    To compare the effectiveness of single-bundle and double-bundle anterior cruciate ligament (ACL) reconstruction by two methods...
  51. Grassi A, Vascellari A, Combi A, Tomaello L, Canata G, Zaffagnini S. Return to sport after ACL reconstruction: a survey between the Italian Society of Knee, Arthroscopy, Sport, Cartilage and Orthopaedic Technologies (SIGASCOT) members. Eur J Orthop Surg Traumatol. 2016;26:509-16 pubmed publisher
    A worldwide consensus for timing and criteria for return to sport after anterior cruciate ligament (ACL) reconstruction is lacking...
  52. Mitchell J, Mayo M, Axibal D, Kasch A, Fader R, Chadayammuri V, et al. Delayed Anterior Cruciate Ligament Reconstruction in Young Patients With Previous Anterior Tibial Spine Fractures. Am J Sports Med. 2016;44:2047-56 pubmed publisher
    ..Avulsion fractures of the anterior tibial spine in young athletes are injuries similar to anterior cruciate ligament (ACL) injuries in adults...
  53. Yellin J, Fabricant P, Gornitzky A, Greenberg E, Conrad S, Dyke J, et al. Rehabilitation Following Anterior Cruciate Ligament Tears in Children: A Systematic Review. JBJS Rev. 2016;4: pubmed publisher
    Anterior cruciate ligament (ACL) tears are increasingly prevalent in the pediatric population...
  54. Stanisavljevic N, Stojanovich L, Marisavljevic D, Djokovic A, Dopsaj V, Kotur Stevuljevic J, et al. Lipid peroxidation as risk factor for endothelial dysfunction in antiphospholipid syndrome patients. Clin Rheumatol. 2016;35:2485-93 pubmed publisher
    ..011); LOOH in PAPS (p = 0.004); LOOH, aCL, and triglycerides in SAPS patients (p = 0.009, p = 0.049, and p = 0.012, respectively)...
  55. Bonanzinga T, Signorelli C, Grassi A, Lopomo N, Bragonzoni L, Zaffagnini S, et al. Kinematics of ACL and anterolateral ligament. Part I: Combined lesion. Knee Surg Sports Traumatol Arthrosc. 2017;25:1055-1061 pubmed publisher
    To quantify the influence of ALL lesions on static and dynamic laxity in ACL-deficient knee. The study was performed in 10 fresh-frozen knees...
  56. Shea K, Milewski M, Cannamela P, Ganley T, Fabricant P, Terhune E, et al. Anterolateral Ligament of the Knee Shows Variable Anatomy in Pediatric Specimens. Clin Orthop Relat Res. 2017;475:1583-1591 pubmed publisher
    Anterior cruciate ligament (ACL) reconstruction failure rates are highest in youth athletes...
  57. Grassi A, Smiley S, Roberti di Sarsina T, Signorelli C, Marcheggiani Muccioli G, Bondi A, et al. Mechanisms and situations of anterior cruciate ligament injuries in professional male soccer players: a YouTube-based video analysis. Eur J Orthop Surg Traumatol. 2017;27:967-981 pubmed publisher
    ..the most popular sport in the world concerning both audience and athlete participation, and the incidence of ACL injury in this sport is high...
  58. Pan J, Wang X, Huang M. [Analysis of the characteristics and clinical diagnosis and treatment of avulsion fracture of the lateral edge of tibial plateau]. Zhongguo Gu Shang. 2018;31:155-159 pubmed publisher
    ..Among them, there were 20 cases of anterior cruciate ligament rupture (ACL rupture) involving the anterior cruciate ligament tibial eminence avulsion fracture included, 3 cases of posterior ..
  59. Lu D, Xiao M, Zhang Y, Yan S, Dong F, Lian Y. [ARTHROSCOPIC STUDY OF REMNANT-PRESERVED RECONSTRUCTION OF ANTERIOR CRUCIATE LIGAMENT]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2015;29:941-4 pubmed
    To investigate the value of ligament remnant preservation during anterior cruciate ligament (ACL) reconstruction by observing the integrity, the tension, the synovial membrane covering, and the color of the reconstructed ligament under ..
  60. Chen Y, Qian J, He Q, Zhao H, Toral Barza L, Shi C, et al. mTOR complex-2 stimulates acetyl-CoA and de novo lipogenesis through ATP citrate lyase in HER2/PIK3CA-hyperactive breast cancer. Oncotarget. 2016;7:25224-40 pubmed publisher
    ..We showed that hyperphosphorylation in ATP citrate lyase (ACL) occurs frequently in human breast tumors and correlates well with HER2+ and/or PIK3CA-mutant (HER2+/..
  61. Takeuchi H, Niki Y, Matsunari H, Umeyama K, Nagashima H, Enomoto H, et al. Temporal Changes in Cellular Repopulation and Collagen Fibril Remodeling and Regeneration After Allograft Anterior Cruciate Ligament Reconstruction: An Experimental Study Using Kusabira-Orange Transgenic Pigs. Am J Sports Med. 2016;44:2375-83 pubmed publisher
    ..cells from donor ligament cells is difficult in the early graft-healing phase after anterior cruciate ligament (ACL) reconstruction...
  62. Oku K, Amengual O, Kato M, Bohgaki T, Horita T, Yasuda S, et al. Significance of fully automated tests for the diagnosis of antiphospholipid syndrome. Thromb Res. 2016;146:1-6 pubmed publisher
    ..To address this issue, we measured aPLs defined according to the classification criteria (anticardiolipin antibody: aCL) IgG/IgM and anti-?2 glycoprotein I antibody (a?2GPI) (IgG/IgM) as well as non-criteria ..
  63. Browning W, Kluczynski M, Curatolo C, Marzo J. Suspensory Versus Aperture Fixation of a Quadrupled Hamstring Tendon Autograft in Anterior Cruciate Ligament Reconstruction: A Meta-analysis. Am J Sports Med. 2017;45:2418-2427 pubmed publisher
    Hamstring grafts have become a popular choice for anterior cruciate ligament (ACL) reconstruction; however, the most effective means of fixation of these soft tissue grafts is unknown...
  64. Cinque M, Geeslin A, Chahla J, Moatshe G, Pogorzelski J, DePhillipo N, et al. The Heel Height Test: A Novel Tool for the Detection of Combined Anterior Cruciate Ligament and Fibular Collateral Ligament Tears. Arthroscopy. 2017;33:2177-2181 pubmed publisher
    ..value of side-to-side difference (SSD) in heel height that was associated with combined anterior cruciate ligament (ACL) and fibular collateral ligament (FCL) tears (compared with an isolated ACL tear) and determine the clinical ..
  65. Taneja A, Miranda F, Demange M, Prado M, Santos D, Rosemberg L, et al. Evaluation of Posterior Cruciate Ligament and Intercondylar Notch in Subjects With Anterior Cruciate Ligament Tear: A Comparative Flexed-Knee 3D Magnetic Resonance Imaging Study. Arthroscopy. 2017;: pubmed publisher
    To determine if posterior cruciate ligament (PCL) and intercondylar notch (IN) morphometries and volumetrics act as risk factors for anterior cruciate ligament (ACL) tears.
  66. Zakko P, van Eck C, Guenther D, Irrgang J, Fu F. Can we predict the size of frequently used autografts in ACL reconstruction?. Knee Surg Sports Traumatol Arthrosc. 2017;25:3704-3710 pubmed publisher
    ..Sixty-two subjects with a mean age of 25 ± 10 years who underwent ACL surgery between 2011 and 2014 were included. Patient anthropometric data were recorded for all subjects...
  67. Paterno M, Kiefer A, Bonnette S, Riley M, Schmitt L, Ford K, et al. Prospectively identified deficits in sagittal plane hip-ankle coordination in female athletes who sustain a second anterior cruciate ligament injury after anterior cruciate ligament reconstruction and return to sport. Clin Biomech (Bristol, Avon). 2015;30:1094-101 pubmed publisher
    Athletes who return to sport after anterior cruciate ligament reconstruction are at increased risk of future ACL injury. Altered coordination of lower extremity motion may increase this risk...
  68. Surer L, Michail K, Koken M, Yapici C, Zhu J, Marshall B, et al. The effect of anterior cruciate ligament graft rotation on knee biomechanics. Knee Surg Sports Traumatol Arthrosc. 2017;25:1093-1100 pubmed publisher
    ..the distal end of the bone-patellar tendon graft 90° in anatomic single-bundle (SB) anterior cruciate ligament (ACL) reconstruction with a porcine model. Twenty (n = 20) porcine knees were evaluated using a robotic testing system...
  69. Monteagudo M, Roset M, Rodriguez Blanco T, Muñoz L, Miravitlles M. Characteristics of COPD patients initiating treatment with aclidinium or tiotropium in primary care in Catalonia: a population-based study. Int J Chron Obstruct Pulmon Dis. 2017;12:1145-1152 pubmed publisher
    To describe and compare demographic and clinical profile of patients newly initiated on aclidinium (ACL) or tiotropium (TIO) and identify factors associated with newly initiated ACL in real-life clinical practice during 2013 in Catalonia...
  70. Chen T, Zhang P, Chen J, Hua Y, Chen S. Long-Term Outcomes of Anterior Cruciate Ligament Reconstruction Using Either Synthetics With Remnant Preservation or Hamstring Autografts: A 10-Year Longitudinal Study. Am J Sports Med. 2017;45:2739-2750 pubmed publisher
    The optimal graft choice of anterior cruciate ligament (ACL) reconstruction remains controversial...
  71. Halewood C, Traynor A, Bellemans J, Victor J, Amis A. Anteroposterior Laxity After Bicruciate-Retaining Total Knee Arthroplasty Is Closer to the Native Knee Than ACL-Resecting TKA: A Biomechanical Cadaver Study. J Arthroplasty. 2015;30:2315-9 pubmed publisher
    ..BCR TKA was shown to be surgically feasible, reduced AP laxity versus CR TKA, and may improve knee stability without using conforming geometry in the implant design. ..
  72. Lessi G, Dos Santos A, Batista L, de Oliveira G, Serrão F. Effects of fatigue on lower limb, pelvis and trunk kinematics and muscle activation: Gender differences. J Electromyogr Kinesiol. 2017;32:9-14 pubmed publisher
    Muscle fatigue is associated with biomechanical changes that may lead to anterior cruciate ligament (ACL) injuries. Alterations in trunk and pelvis kinematics may also be involved in ACL injury...
  73. Jia Z, Zhang C, Cao S, Xue C, Liu T, Huang X, et al. Comparison of artificial graft versus autograft in anterior cruciate ligament reconstruction: a meta-analysis. BMC Musculoskelet Disord. 2017;18:309 pubmed publisher
    ..and summarization for the outcomes between autografts and artificial grafts using in anterior cruciate ligament (ACL) reconstruction have not been performed currently...
  74. Taylor J, Ford K, Schmitz R, Ross S, Ackerman T, Shultz S. A 6-week warm-up injury prevention programme results in minimal biomechanical changes during jump landings: a randomized controlled trial. Knee Surg Sports Traumatol Arthrosc. 2018;26:2942-2951 pubmed publisher
    To examine the extent to which an ACL injury prevention programme modifies lower extremity biomechanics during single- and double-leg landing tasks in both the sagittal and frontal plane...
  75. Srivastava V, Deshpande S, Nimgaonkar V, Lerer B, Thelma B. Genetic correlates of olanzapine-induced weight gain in schizophrenia subjects from north India: role of metabolic pathway genes. Pharmacogenomics. 2008;9:1055-68 pubmed publisher
    ..The leptin gene may be a promising candidate for olanzapine-induced weight gain. As the associations are modest, replicate studies are warranted. This approach may facilitate rationalized drug regimens. ..
  76. Drews B, Seitz A, Huth J, Bauer G, Ignatius A, Dürselen L. ACL double-bundle reconstruction with one tibial tunnel provides equal stability compared to two tibial tunnels. Knee Surg Sports Traumatol Arthrosc. 2017;25:1646-1652 pubmed publisher
    The purpose of this study was to investigate whether an anterior cruciate ligament (ACL) double-bundle reconstruction with one tibial tunnel displays the same in vitro stability as a conventional double-bundle reconstruction with two ..
  77. Liu Y, Cui G, Yan H, Yang Y, Ao Y. Comparison Between Single- and Double-Bundle Anterior Cruciate Ligament Reconstruction With 6- to 8-Stranded Hamstring Autograft: A Prospective, Randomized Clinical Trial. Am J Sports Med. 2016;44:2314-22 pubmed publisher
    Whether double-bundle (DB) anterior cruciate ligament (ACL) reconstruction with 6- to 8-stranded hamstring autograft (HG) is better than single-bundle (SB) ACL reconstruction remains debatable, as long-term follow-up data are lacking...
  78. Ithurburn M, Altenburger A, Thomas S, Hewett T, Paterno M, Schmitt L. Young athletes after ACL reconstruction with quadriceps strength asymmetry at the time of return-to-sport demonstrate decreased knee function 1 year later. Knee Surg Sports Traumatol Arthrosc. 2018;26:426-433 pubmed publisher
    Quadriceps femoris (QF) strength deficits at return-to-sport (RTS) after ACL reconstruction (ACLR) contribute to decreased knee function at the same time point...
  79. Stralfors P. Isoproterenol and insulin control the cellular localization of ATP citrate-lyase through its phosphorylation in adipocytes. J Biol Chem. 1987;262:11486-9 pubmed
    ..It is suggested that the state of phosphorylation of ATP citrate-lyase in adipocytes controls the localization in the cell. ..
  80. Chen W, Chen Y, Huang S, Yang C, Wu C, Chang C. Landing strategies focusing on the control of tibial rotation in the initial contact period of one-leg forward hops. Scand J Med Sci Sports. 2017;27:832-841 pubmed publisher
    Anterior cruciate ligament (ACL) reconstruction (ACLR) surgeries successfully restore anterior tibial translation but not tibial rotation...
  81. Vysochan A, Sengupta A, Weljie A, Alwine J, Yu Y. ACSS2-mediated acetyl-CoA synthesis from acetate is necessary for human cytomegalovirus infection. Proc Natl Acad Sci U S A. 2017;114:E1528-E1535 pubmed publisher
    ..Here we show that HCMV-infected cells produce more glucose-derived pyruvate, which can be converted to acetate through a nonenzymatic mechanism. ..
  82. Shovman O, Tamar S, Amital H, Watad A, Shoenfeld Y. Diverse patterns of anti-TNF-?-induced lupus: case series and review of the literature. Clin Rheumatol. 2018;37:563-568 pubmed publisher
    ..all three cases exhibited ANA and anti-dsDNA positivity, and only the second patient had anticardiolipin (aCL IgG) and anti-histone antibodies...
  83. Wilk K, Reinold M, Hooks T. Recent advances in the rehabilitation of isolated and combined anterior cruciate ligament injuries. Orthop Clin North Am. 2003;34:107-37 pubmed
    The rehabilitation process begins immediately following ACL injury, with emphasis on reducing swelling and inflammation; improving motion; regaining quadriceps control; allowing immediate weight-bearing; and restoring full passive knee ..
  84. Yu Y, Maguire T, Alwine J. Human cytomegalovirus activates glucose transporter 4 expression to increase glucose uptake during infection. J Virol. 2011;85:1573-80 pubmed publisher
    ..GLUT4 expression that involve serum stimulation, glucose concentration, and nuclear functions of ATP-citrate lyase (ACL)...
  85. Zhou Y, Bollu L, Tozzi F, Ye X, Bhattacharya R, Gao G, et al. ATP citrate lyase mediates resistance of colorectal cancer cells to SN38. Mol Cancer Ther. 2013;12:2782-91 pubmed publisher
    ..Using Oncomine and unbiased proteomic profiling, we found that ATP citrate lyase (ACLy), the first-step rate-limiting enzyme for de novo lipogenesis, was upregulated in colorectal cancer ..
  86. Gupta R, Malhotra A, Kumar P, Masih G. Correlation of femoral tunnel length with body height, limb length, and thigh length in Indian patients undergoing anterior cruciate ligament reconstruction. J Orthop Surg (Hong Kong). 2016;24:286-288 pubmed
    ..with body height, limb length, and thigh length in 404 Indian patients undergoing anterior cruciate ligament (ACL) reconstruction. 364 male and 40 female Indian patients aged 18 to 51 (mean, 26...
  87. Gupta R, Sood M, Malhotra A, Masih G, Kapoor A, Raghav M, et al. Low re-rupture rate with BPTB autograft and semitendinosus gracilis autograft with preserved insertions in ACL reconstruction surgery in sports persons. Knee Surg Sports Traumatol Arthrosc. 2018;26:2381-2388 pubmed publisher
    ..Two hundred and forty-nine elite and recreational players who underwent ACL reconstruction surgery, with BPTB graft (N?=?80), STGPI graft (N?=?85), and STGF graft (N?=?84) with a minimum ..
  88. Xu H, Dong J, Xin D, Zhang J, Kang K, Gao S. Second-Look Arthroscopic Evaluation and Clinical Outcomes of Anatomic Anterior Cruciate Ligament Reconstruction with Autograft and Hybrid Graft: A Retrospective Study. Med Sci Monit. 2017;23:5564-5573 pubmed
    ..This study compared the second-look evaluation and clinical outcomes of anatomic ACL-R using a thin autograft versus a thick hybrid graft...
  89. Zaidi N, Swinnen J, Smans K. ATP-citrate lyase: a key player in cancer metabolism. Cancer Res. 2012;72:3709-14 pubmed publisher
    ..The present review highlights current knowledge about the role of ACLY in cancer cells, with special reference to the different pathways that are linked by ACLY. ..
  90. Han C, Yang L, Choi H, Baddour J, Achreja A, Liu Y, et al. Amplification of USP13 drives ovarian cancer metabolism. Nat Commun. 2016;7:13525 pubmed publisher
    ..USP13 specifically deubiquitinates and thus upregulates ATP citrate lyase and oxoglutarate dehydrogenase, two key enzymes that determine mitochondrial respiration, glutaminolysis and ..
  91. Arundale A, Cummer K, Capin J, Zarzycki R, Snyder Mackler L. Report of the Clinical and Functional Primary Outcomes in Men of the ACL-SPORTS Trial: Similar Outcomes in Men Receiving Secondary Prevention With and Without Perturbation Training 1 and 2 Years After ACL Reconstruction. Clin Orthop Relat Res. 2017;475:2523-2534 pubmed publisher
    Athletes often are cleared to return to activities 6 months after anterior cruciate ligament (ACL) reconstruction; however, knee function measures continue to improve up to 2 years after surgery...
  92. Wang Y, Shimmin A, Ghosh P, Marks P, Linklater J, Connell D, et al. Safety, tolerability, clinical, and joint structural outcomes of a single intra-articular injection of allogeneic mesenchymal precursor cells in patients following anterior cruciate ligament reconstruction: a controlled double-blind randomised trial. Arthritis Res Ther. 2017;19:180 pubmed publisher
    ..symptoms and retard joint structural deterioration over 24 months in patients following anterior cruciate ligament (ACL) reconstruction...