ASIC1

Summary

Gene Symbol: ASIC1
Description: acid sensing ion channel subunit 1
Alias: ACCN2, ASIC, BNaC2, acid-sensing ion channel 1, Cation channel, amiloride-sensitive, neuronal, 2, acid sensing (proton gated) ion channel 1, acid-sensing ion channel 1a protein, amiloride-sensitive cation channel 2, neuronal, brain sodium channel 2
Species: human
Products:     ASIC1

Top Publications

  1. Corey D, Garcia Anoveros J. Mechanosensation and the DEG/ENaC ion channels. Science. 1996;273:323-4 pubmed
  2. Leonard A, Yermolaieva O, Hruska Hageman A, Askwith C, Price M, Wemmie J, et al. cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1. Proc Natl Acad Sci U S A. 2003;100:2029-34 pubmed
    The acid-sensing ion channel-1 (ASIC1) contributes to synaptic plasticity and may influence the response to cerebral ischemia and acidosis...
  3. Wemmie J, Coryell M, Askwith C, Lamani E, Leonard A, Sigmund C, et al. Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior. Proc Natl Acad Sci U S A. 2004;101:3621-6 pubmed
    ..Studies of mice with a disrupted ASIC1 gene suggested that ASIC1a may contribute to learned fear...
  4. Askwith C, Cheng C, Ikuma M, Benson C, Price M, Welsh M. Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels. Neuron. 2000;26:133-41 pubmed
    ..current on their own but potentiated H+-gated currents from cultured sensory neurons and heterologously expressed ASIC and DRASIC channels. The neuropeptides slowed inactivation and induced sustained currents during acidification...
  5. Wemmie J, Chen J, Askwith C, Hruska Hageman A, Price M, Nolan B, et al. The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory. Neuron. 2002;34:463-77 pubmed
    ..We found that eliminating the acid sensing ion channel (ASIC) abolished H(+)-gated currents in hippocampal neurons...
  6. Kapoor N, Bartoszewski R, Qadri Y, Bebok Z, Bubien J, Fuller C, et al. Knockdown of ASIC1 and epithelial sodium channel subunits inhibits glioblastoma whole cell current and cell migration. J Biol Chem. 2009;284:24526-41 pubmed publisher
    ..Using quantitative real time PCR, we have shown higher expression of ASIC1, alphaENaC, and gammaENaC in D54-MG human glioblastoma multiforme cells compared with primary human astrocytes...
  7. Hoagland E, Sherwood T, Lee K, Walker C, Askwith C. Identification of a calcium permeable human acid-sensing ion channel 1 transcript variant. J Biol Chem. 2010;285:41852-62 pubmed publisher
    ..In rodents, the Accn2 gene encodes transcript variants ASIC1a and ASIC1b, which differ in the first third of the protein and display ..
  8. Dawson R, Benz J, Stohler P, Tetaz T, Joseph C, Huber S, et al. Structure of the acid-sensing ion channel 1 in complex with the gating modifier Psalmotoxin 1. Nat Commun. 2012;3:936 pubmed publisher
    ..Our results provide a general concept for gating modifier toxin binding suggesting that both surface motifs are required to modify the gating characteristics of an ion channel. ..
  9. Garcia Anoveros J, Derfler B, Neville Golden J, Hyman B, Corey D. BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels. Proc Natl Acad Sci U S A. 1997;94:1459-64 pubmed
    ..We have identified two new members of this superfamily (BNaC1 and BNaC2) in a human brain cDNA library...

More Information

Publications110 found, 100 shown here

  1. Waldmann R, Champigny G, Bassilana F, Heurteaux C, Lazdunski M. A proton-gated cation channel involved in acid-sensing. Nature. 1997;386:173-7 pubmed
    ..We have now cloned a H+-gated channel (ASIC, for acid-sensing ionic channel) that belongs to the amiloride-sensitive Na+ channel/degenerin family of ion ..
  2. Gunthorpe M, Smith G, Davis J, Randall A. Characterisation of a human acid-sensing ion channel (hASIC1a) endogenously expressed in HEK293 cells. Pflugers Arch. 2001;442:668-74 pubmed
    ..With this latter point in mind we have devised a simple desensitisation strategy to selectively remove the contribution of hASIC1a from proton-gated currents recorded from HEK293 cells expressing vanilloid receptor-1. ..
  3. Duggan A, Garcia Anoveros J, Corey D. The PDZ domain protein PICK1 and the sodium channel BNaC1 interact and localize at mechanosensory terminals of dorsal root ganglion neurons and dendrites of central neurons. J Biol Chem. 2002;277:5203-8 pubmed
    ..BNaC1 is similar to two other BNaC/ASIC family members, BNaC2 (ASIC1) and ASIC4, at its extreme C terminus, and we show that PICK1 also interacts with BNaC2...
  4. Cho J, Askwith C. Potentiation of acid-sensing ion channels by sulfhydryl compounds. Am J Physiol Cell Physiol. 2007;292:C2161-74 pubmed
    ..Thus sulfhydryl compounds potentiate H(+)-gated currents via two mechanisms, metal chelation and redox modulation of target amino acids. ..
  5. Sherwood T, Askwith C. Endogenous arginine-phenylalanine-amide-related peptides alter steady-state desensitization of ASIC1a. J Biol Chem. 2008;283:1818-30 pubmed
    ..Furthermore, our finding that endogenous peptides shift steady-state desensitization suggests that RF-amides could impact the role of ASIC1a in both pain and neuronal damage following stroke and ischemia. ..
  6. Bargeton B, Kellenberger S. The contact region between three domains of the extracellular loop of ASIC1a is critical for channel function. J Biol Chem. 2010;285:13816-26 pubmed publisher
    ..4 to 6.8, suggesting that this zone undergoes conformational changes during inactivation. Our study identifies a region in ASIC1a whose integrity is required for normal channel function. ..
  7. Hruska Hageman A, Wemmie J, Price M, Welsh M. Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel). Biochem J. 2002;361:443-50 pubmed
    ..DEG/ENaC) family of cation channels include the mammalian brain Na(+) channel 1 (BNC1), acid-sensing ion channel (ASIC) and dorsal-root acid-sensing ion channel (DRASIC)...
  8. Hanukoglu I, Hanukoglu A. Epithelial sodium channel (ENaC) family: Phylogeny, structure-function, tissue distribution, and associated inherited diseases. Gene. 2016;579:95-132 pubmed publisher
    ..ENaC orthologs and paralogs, and their distinction from other members of the ENaC/Degenerin superfamily, especially ASIC family...
  9. Zhou Z, Song J, Li W, Liu X, Cao L, Wan L, et al. The acid-sensing ion channel, ASIC2, promotes invasion and metastasis of colorectal cancer under acidosis by activating the calcineurin/NFAT1 axis. J Exp Clin Cancer Res. 2017;36:130 pubmed publisher
    ..We examined the expression of the acid-sending ion channel (ASIC) family members after acidic exposure using RT-PCR and immunofluoresence...
  10. Wu L, Oshima T, Shan J, Sei H, Tomita T, Ohda Y, et al. PAR-2 activation enhances weak acid-induced ATP release through TRPV1 and ASIC sensitization in human esophageal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2015;309:G695-702 pubmed publisher
    ..pretreatment with 5-iodoresiniferatoxin (IRTX), a TRPV1-specific antagonist, or with amiloride, a nonselective ASIC blocker. TRPV1 and ASIC3 small interfering RNA (siRNA) transfection also decreased weak acid-induced ATP release...
  11. Lei Z, Sami Shaikh A, Zheng W, Yu X, Yu J, Li J. Non-proton ligand-sensing domain of acid-sensing ion channel 3 is required for itch sensation. J Neurochem. 2016;139:1093-1101 pubmed publisher
    ..In conclusion, ASIC3, a proton-gated ion channel critical for pain sensation, also functions as an essential component of itch transduction. ..
  12. Xu S, Liu C, Ma Y, Ji H, Li X. Potential Roles of Amiloride-Sensitive Sodium Channels in Cancer Development. Biomed Res Int. 2016;2016:2190216 pubmed publisher
    ..superfamily includes the amiloride-sensitive epithelial sodium channel (ENaC) and acid sensitive ionic channel (ASIC)...
  13. Cheng Z, Chen Y, Li X, Qin P, Liang F, Rong P. [Effects of Electroacupuncture on Expression of Myocardial Chloride Channel-2 and CLCA Proteins in Mice with Acute Myocardial Ischemia]. Zhen Ci Yan Jiu. 2016;41:423-8 pubmed
    ..Thirty ASIC 3-/- knock out mice were randomly divided into control, AMI model, EA-Neiguan (PC 6), EA-Lieque (LU 7) ..
  14. Yu X, Hu Z, Ni M, Fang P, Zhang P, Shu Q, et al. Acid-sensing ion channels promote the inflammation and migration of cultured rat microglia. Glia. 2015;63:483-96 pubmed publisher
    ..quantitative real-time PCR (qPCR), western blotting, and immunofluorescence experiments, we demonstrated that ASIC1, ASIC2a, and ASIC3 were existed in cultured and in situ rat microglia...
  15. Holzer P. Acid-sensing ion channels in gastrointestinal function. Neuropharmacology. 2015;94:72-9 pubmed publisher
    ..In the gut, ASICs (ASIC1, ASIC2, ASIC3) are primarily expressed by the peripheral axons of vagal and spinal afferent neurons and are ..
  16. Yang S, Ning F, Li J, Guo D, Zhang L, Cui R, et al. Therapeutic Effect Analysis of Sinomenine on Rat Cerebral Ischemia-Reperfusion Injury. J Stroke Cerebrovasc Dis. 2016;25:1263-1269 pubmed publisher
    ..Acid-sensing ion channel (ASIC) 1a mRNA level was determined by quantitative real-time polymerase chain reaction; ischemic brain contents of ..
  17. Winter A, Stäubert S, Ammon D, Aiche S, Beyan O, Bischoff V, et al. Smart Medical Information Technology for Healthcare (SMITH). Methods Inf Med. 2018;57:e92-e105 pubmed publisher
    ..The clinical use case "Algorithmic Surveillance of ICU Patients" (ASIC) focusses on patients in Intensive Care Units (ICU) with the acute respiratory distress syndrome (ARDS)...
  18. Cittaro D, Lampis V, Luchetti A, Coccurello R, Guffanti A, Felsani A, et al. Histone Modifications in a Mouse Model of Early Adversities and Panic Disorder: Role for Asic1 and Neurodevelopmental Genes. Sci Rep. 2016;6:25131 pubmed publisher
    ..Among these genes, Asic1 showed heightened mRNA expression, coherent with RCF-mice's respiratory hypersensitivity to CO2 and altered ..
  19. Schuhmacher L, Callejo G, Srivats S, Smith E. Naked mole-rat acid-sensing ion channel 3 forms nonfunctional homomers, but functional heteromers. J Biol Chem. 2017;: pubmed publisher
    ..b>ASIC proteins can form both homotrimeric and heterotrimeric ion channels...
  20. Boscardin E, Alijevic O, Hummler E, Frateschi S, Kellenberger S. The function and regulation of acid-sensing ion channels (ASICs) and the epithelial Na(+) channel (ENaC): IUPHAR Review 19. Br J Pharmacol. 2016;173:2671-701 pubmed publisher
    ..ENaC is a clinically used drug target in the context of hypertension and cystic fibrosis, while ASIC is an interesting potential target...
  21. Ni L, Fang P, Hu Z, Zhou H, Chen J, Wang F, et al. Identification and Function of Acid-sensing Ion Channels in RAW 264.7 Macrophage Cells. Curr Med Sci. 2018;38:436-442 pubmed publisher
    ..Macrophage recruitment to the sites of inflammation is an essential step in host defense. ASIC1 and ASIC3 have been reported to mediate the endocytosis and maturation of bone marrow derived macrophages...
  22. Husson Z, Smith E. Naked mole-rat cortical neurons are resistant to acid-induced cell death. Mol Brain. 2018;11:26 pubmed publisher
    ..In the central nervous system, ASIC subunit expression is similar between mouse and NMR with the exception of much lower expression of ASIC4 throughout ..
  23. Kalina R, Gladkikh I, Dmitrenok P, Chernikov O, Koshelev S, Kvetkina A, et al. New APETx-like peptides from sea anemone Heteractis crispa modulate ASIC1a channels. Peptides. 2018;104:41-49 pubmed publisher
    ..Electrophysiological experiments on homomeric ASIC channels expressed in Xenopus laevis oocytes establish that these peptides are the first inhibitors of ASIC1a ..
  24. Abboud F, Benson C. ASICs and cardiovascular homeostasis. Neuropharmacology. 2015;94:87-98 pubmed publisher
    ..There is also evidence that ASIC heteromers in skeletal muscle afferents contribute significantly to the exercise pressor reflex...
  25. Ergonul Z, Yang L, Palmer L. Properties of acid-induced currents in mouse dorsal root ganglia neurons. Physiol Rep. 2016;4: pubmed publisher
    ..acid signals sustained currents are maintained in the absence of extracellular Na(+) or the presence of the ASIC blockers amiloride and Psalmotoxin-1(PcTx1)...
  26. Liang J, Huang L, Chen X, Pan S, Lu Z, Xiao Z. Amiloride suppresses pilocarpine-induced seizures via ASICs other than NHE in rats. Int J Clin Exp Pathol. 2015;8:14507-13 pubmed
    ..While NHE mRNA expression in the SE groups showed no significant difference. Amiloride inhibited pilocarpine-induced SE and the anti-epileptic mechanism was associated with deactivation of the ASIC1a and ASIC3 instead of NHE in rats. ..
  27. Kreple C, Lu Y, Taugher R, Schwager Gutman A, Du J, Stump M, et al. Acid-sensing ion channels contribute to synaptic transmission and inhibit cocaine-evoked plasticity. Nat Neurosci. 2014;17:1083-91 pubmed publisher
    ..Together, these data suggest that ASIC1A inhibits the plasticity underlying addiction-related behavior and raise the possibility of developing therapies for drug addiction by targeting ASIC-dependent neurotransmission.
  28. Leng T, Si H, Li J, Yang T, Zhu M, Wang B, et al. Amiloride Analogs as ASIC1a Inhibitors. CNS Neurosci Ther. 2016;22:468-76 pubmed publisher
    ..In addition, amiloride and its analogs inhibit ASIC currents in cortical neurons with the same potency rank order...
  29. Lin L, Jones S, Talman W. Cellular Localization of Acid-Sensing Ion Channel 1 in Rat Nucleus Tractus Solitarii. Cell Mol Neurobiol. 2018;38:219-232 pubmed publisher
    ..NTS), we sought anatomical support for a putative physiological role for acid-sensing ion channel Type 1 (ASIC1) in chemosensitivity. Further, we sought to determine the effect of a lesion that produces gliosis in the area...
  30. Kanaya K, Iba K, Dohke T, Okazaki S, Yamashita T. TRPV1, ASICs and P2X2/3 expressed in bone cells simultaneously regulate bone metabolic markers in ovariectomized mice. J Musculoskelet Neuronal Interact. 2016;16:145-51 pubmed
    ..ASIC 2 and 3, and P2X2 and 3, were expressed in bone tissue and bone marrow cells, and the expression levels of ASIC1 and 2, and P2X2 were significantly increased in OVX mice in comparison with those in sham mice...
  31. Levanti M, Randazzo B, Vina E, Montalbano G, Garcia Suarez O, Germana A, et al. Acid-sensing ion channels and transient-receptor potential ion channels in zebrafish taste buds. Ann Anat. 2016;207:32-7 pubmed publisher
    ..mini-review summarizes current knowledge on the presence of transient-receptor potential (TRP) and acid-sensing (ASIC) ion channels in the taste buds of teleosts, especially adult zebrafish...
  32. Clarke C, Rieger R, Schuettler M, Donaldson N, Taylor J. An implantable ENG detector with in-system velocity selective recording (VSR) capability. Med Biol Eng Comput. 2017;55:885-895 pubmed publisher
    ..The digital ASIC provides the signal processing required to detect selectively ENG signals based on velocity...
  33. Shire D, Ellersick W, Kelly S, Doyle P, Priplata A, Drohan W, et al. ASIC design and data communications for the Boston retinal prosthesis. Conf Proc IEEE Eng Med Biol Soc. 2012;2012:292-5 pubmed publisher
    We report on the design and testing of a custom application-specific integrated circuit (ASIC) that has been developed as a key component of the Boston retinal prosthesis...
  34. Chen B, Liu J, Ho T, Ding X, Mo Y. ERK-mediated NF-?B activation through ASIC1 in response to acidosis. Oncogenesis. 2016;5:e279 pubmed publisher
    ..We have previously shown that neuron specific acid-sensing ion channel 1 (ASIC1) is expressed in breast cancer, and it is responsible for acidosis-induced cellular signaling through AKT, leading ..
  35. Bhowmick S, Moore J, Kirschner D, Curry M, Westbrook E, Rasley B, et al. Acidotoxicity via ASIC1a Mediates Cell Death during Oxygen Glucose Deprivation and Abolishes Excitotoxicity. ACS Chem Neurosci. 2017;8:1204-1212 pubmed publisher
    ..The role of ASIC1a and NMDAR was deciphered by treating the slices with and without an ASIC or NMDAR antagonist...
  36. Vralsted V, Price M, Du J, Schnizler M, Wunsch A, Ziemann A, et al. Expressing acid-sensing ion channel 3 in the brain alters acid-evoked currents and impairs fear conditioning. Genes Brain Behav. 2011;10:444-50 pubmed publisher
    ..Moreover, these data suggest that ASIC subunit composition and channel desensitization may be critical determinants for ASIC-dependent behavior.
  37. Orts Del Immagine A, Seddik R, Tell F, Airault C, Er Raoui G, Najimi M, et al. A single polycystic kidney disease 2-like 1 channel opening acts as a spike generator in cerebrospinal fluid-contacting neurons of adult mouse brainstem. Neuropharmacology. 2016;101:549-65 pubmed publisher
    ..b>ASIC) generating specific responses...
  38. Liu G, Yan G, Zhao S, Kuang S. A complexity-efficient and one-pass image compression algorithm for wireless capsule endoscopy. Technol Health Care. 2015;23 Suppl 2:S239-47 pubmed publisher
    As an important part of the application-specific integrated circuit (ASIC) in wireless capsule endoscopy (WCE), the efficient compressor is crucial for image transmission and power consumption...
  39. Wang J, Kaletsky R, Silva M, Williams A, Haas L, Androwski R, et al. Cell-Specific Transcriptional Profiling of Ciliated Sensory Neurons Reveals Regulators of Behavior and Extracellular Vesicle Biogenesis. Curr Biol. 2015;25:3232-8 pubmed publisher
    ..EV biogenesis and polycystin signaling and also identified EV cargo, which included an antimicrobial peptide and ASIC channel...
  40. Tian Y, Bresenitz P, Reska A, El Moussaoui L, Beier C, Grunder S. Glioblastoma cancer stem cell lines express functional acid sensing ion channels ASIC1a and ASIC3. Sci Rep. 2017;7:13674 pubmed publisher
    ..We detected transcripts of the ACCN2 and ACCN3 genes, coding for ASIC1 and ASIC3, respectively, but not transcripts of ACCN1 (coding for ASIC2)...
  41. Piech D, Kay J, BOSER B, Maharbiz M. Rodent wearable ultrasound system for wireless neural recording. Conf Proc IEEE Eng Med Biol Soc. 2017;2017:221-225 pubmed publisher
    ..The system integrates a front-end ultrasonic interface ASIC with off-the-shelf components to enable a highly compact ultrasound interrogation device intended for rodent neural ..
  42. Bubien J, Keeton D, Fuller C, Gillespie G, Reddy A, Mapstone T, et al. Malignant human gliomas express an amiloride-sensitive Na+ conductance. Am J Physiol. 1999;276:C1405-10 pubmed
    ..RT-PCR analyses demonstrated the presence of mRNA for either BNaC1 or BNaC2 in these tumors and in normal astrocytes...
  43. Coryell M, Wunsch A, Haenfler J, Allen J, Schnizler M, Ziemann A, et al. Acid-sensing ion channel-1a in the amygdala, a novel therapeutic target in depression-related behavior. J Neurosci. 2009;29:5381-8 pubmed publisher
    ..These data are consistent with clinical studies emphasizing the importance of the amygdala in mood regulation, and suggest that ASIC1a antagonists may effectively combat depression. ..
  44. Liu T, Qu Z, Ren C, Gan X, Qiu C, Hu W. Prolactin potentiates the activity of acid-sensing ion channels in female rat primary sensory neurons. Neuropharmacology. 2016;103:174-82 pubmed publisher
    ..First, PRL dose-dependently increased the amplitude of ASIC currents with an EC50 of (5.89 ± 0.28) × 10(-8) M...
  45. Sherwood T, Franke R, Conneely S, Joyner J, Arumugan P, Askwith C. Identification of protein domains that control proton and calcium sensitivity of ASIC1a. J Biol Chem. 2009;284:27899-907 pubmed publisher
    ..These results indicate that specific regions play overlapping roles in pH-dependent gating and PcTx1-dependent modulation of ASIC1a activity, whereas a distinct region determines the calcium dependence of ASIC1a activation. ..
  46. Matthewman C, Miller Fleming T, Miller D, Bianchi L. Ca2+ permeability and Na+ conductance in cellular toxicity caused by hyperactive DEG/ENaC channels. Am J Physiol Cell Physiol. 2016;311:C920-C930 pubmed publisher
    ..Our work further refines the contribution of different channel properties to cellular toxicity induced by hyperactive DEG/ENaC channels. ..
  47. Chen Y, Cui Y, O CONNOR P, Seo Y, Camarda G, Hossain A, et al. Test of a 32-channel Prototype ASIC for Photon Counting Application. IEEE Nucl Sci Symp Conf Rec (1997). 2015;2015: pubmed publisher
    A new low-power application-specific integrated circuit (ASIC) for Cadmium Zinc Telluride (CZT) detectors for single-photon emission computed tomography (SPECT) application is being developed at BNL...
  48. Guo W, Chen X, He J, Wei Y, Zang Z, Liu S, et al. Down-regulated expression of acid-sensing ion channel 1a in cortical lesions of patients with focal cortical dysplasia. J Mol Neurosci. 2014;53:176-82 pubmed publisher
    ..In conclusion, the downregulation and altered cellular distribution of ASIC1a in FCD suggest that ASIC1a may potentially contribute to the epileptogenesis of FCD. ..
  49. Gohin S, Decorps J, Sigaudo Roussel D, Fromy B. Sensory nerves contribute to cutaneous vasodilator response to cathodal stimulation in healthy rats. Microvasc Res. 2015;101:103-10 pubmed publisher
    ..of cutaneous transient receptor potential vanilloid type-1 (TRPV1) channels and/or acid-sensing ion channels (ASIC) (activators mechanisms) and the release of calcitonin gene-related peptide (CGRP) and substance P (SP) (effector ..
  50. Chen Y, Hwang W, Ke C. An Efficient VLSI Architecture for Multi-Channel Spike Sorting Using a Generalized Hebbian Algorithm. Sensors (Basel). 2015;15:19830-51 pubmed publisher
    ..The architecture has been implemented by an application-specific integrated circuit (ASIC) with 90-nm technology...
  51. Xu J, Wang N, Luo J, Xia J. Syntabulin regulates the trafficking of PICK1-containing vesicles in neurons. Sci Rep. 2016;6:20924 pubmed publisher
    ..Furthermore, we show that syntabulin forms a complex with PICK1 and ASICs, regulates ASIC protein expression in neurons, and participates in ASIC-induced acidotoxicity.
  52. Gonzalez Bosc L, Plomaritas D, Herbert L, Giermakowska W, Browning C, Jernigan N. ASIC1-mediated calcium entry stimulates NFATc3 nuclear translocation via PICK1 coupling in pulmonary arterial smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2016;311:L48-58 pubmed publisher
    ..with increased pulmonary arterial smooth muscle cell (PASMC) Ca(2+) influx through acid-sensing ion channel-1 (ASIC1) and activation of the Ca(2+)/calcineurin-dependent transcription factor known as nuclear factor of activated T-..
  53. Lee J, Saez N, Cristofori Armstrong B, Anangi R, King G, Smith M, et al. Inhibition of acid-sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain. Br J Pharmacol. 2017;: pubmed publisher
    ..The antiprotozoal drug diminazene is a moderately potent ASIC inhibitor but its analgesic activity has not been assessed.
  54. Saez N, Deplazes E, Cristofori Armstrong B, Chassagnon I, Lin X, Mobli M, et al. Molecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid-sensing ion channel 1a. Br J Pharmacol. 2015;172:4985-95 pubmed publisher
    ..loop; conclusions confirmed by recent crystal structures of the complex formed between PcTx1 and chicken ASIC1 (cASIC1)...
  55. Qu Z, Liu T, Ren C, Gan X, Qiu C, Ren P, et al. 17?-Estradiol Enhances ASIC Activity in Primary Sensory Neurons to Produce Sex Difference in Acidosis-Induced Nociception. Endocrinology. 2015;156:4660-71 pubmed publisher
    ..E2 dose dependently increased the amplitude of ASIC currents with a 42.8 ± 1.6 nM of EC50. E2 shifted the concentration-response curve for proton upward with a 50...
  56. Liu M, Li H, Li W, Wu Y, Deng S, Huang C, et al. Acid-sensing ion channel 1a contributes to hippocampal LTP inducibility through multiple mechanisms. Sci Rep. 2016;6:23350 pubmed publisher
    ..This unbiased study also demonstrates a novel and objective way to assay synaptic plasticity mechanisms in the brain. ..
  57. Berdiev B, Xia J, Jovov B, Markert J, Mapstone T, Gillespie G, et al. Protein kinase C isoform antagonism controls BNaC2 (ASIC1) function. J Biol Chem. 2002;277:45734-40 pubmed
    We explored the involvement of protein kinase C (PKC) and its isoforms in the regulation of BNaC2. Reverse transcriptase PCR evaluation of PKC isoform expression at the level of mRNA revealed the presence of alpha and epsilon/epsilon' in ..
  58. Poirot O, Vukicevic M, Boesch A, Kellenberger S. Selective regulation of acid-sensing ion channel 1 by serine proteases. J Biol Chem. 2004;279:38448-57 pubmed
    ..Thus, we have identified a mechanism that modulates ASIC function and may allow ASIC1a to adapt its gating to situations of persistent extracellular acidification.
  59. Chai S, Li M, Lan J, Xiong Z, Saugstad J, Simon R. A kinase-anchoring protein 150 and calcineurin are involved in regulation of acid-sensing ion channels ASIC1a and ASIC2a. J Biol Chem. 2007;282:22668-77 pubmed
    Acid-sensing ion channel (ASIC) 1a and ASIC2a are acid-sensing ion channels in central and peripheral neurons...
  60. Zhao D, Ning N, Lei Z, Sun H, Wei C, Chen D, et al. Identification of a novel protein complex containing ASIC1a and GABAA receptors and their interregulation. PLoS ONE. 2014;9:e99735 pubmed publisher
    ..Our results indicate that putative GABAA and ASIC1a channels functionally interact with each other, possibly via an inter-molecular association by forming a novel protein complex. ..
  61. Drummond H, Xiang L, Chade A, Hester R. Enhanced maximal exercise capacity, vasodilation to electrical muscle contraction, and hind limb vascular density in ASIC1a null mice. Physiol Rep. 2017;5: pubmed publisher
    Acid-sensing ion channel (ASIC) proteins form extracellular proton-gated, cation-selective channels in neurons and vascular smooth muscle cells and are proposed to act as extracellular proton sensors...
  62. Tian L, Wang J, Zhao M, Bao Y, Shang J, Yan Q, et al. [Effect of Scalp-acupuncture Stimulation on Neurological Function and Expression of ASIC 1 a and ASIC 2 b of Hippocampal CA 1 Region in Cerebral Ischemia Rats]. Zhen Ci Yan Jiu. 2016;41:417-22 pubmed
    ..The neurological deficit score was given according to Longa's method. The expression of hippocampal ASIC 1 a and ASIC 2 b was detected by immunohistochemistry, and the Ca2+ concentration in the hippocampal ..
  63. Stankowska D, Mueller B, Oku H, Ikeda T, Dibas A. Neuroprotective effects of inhibitors of Acid-Sensing ion channels (ASICs) in optic nerve crush model in rodents. Curr Eye Res. 2017;:1-12 pubmed publisher
    The purpose of the current study was to assess the potential involvement of acid-sensing ion channel 1 (ASIC1) in retinal ganglion cell (RGC) death and investigate the neuroprotective effects of inhibitors of ASICs in promoting RGC ..
  64. Jones N, Slater R, Cadiou H, McNaughton P, McMahon S. Acid-induced pain and its modulation in humans. J Neurosci. 2004;24:10974-9 pubmed
    ..inhibited the pain induced by iontophoresis of acid, suggesting an involvement of acid-sensing ion channel (ASIC) receptors...
  65. Smoller J, Gallagher P, Duncan L, McGrath L, Haddad S, Holmes A, et al. The human ortholog of acid-sensing ion channel gene ASIC1a is associated with panic disorder and amygdala structure and function. Biol Psychiatry. 2014;76:902-10 pubmed publisher
    ..We examined whether the human ortholog of the ASIC1a gene, ACCN2, is associated with the presence of PD and with amygdala structure and function...
  66. Yu X, Hu Y, Yu S. Effects of acid on vagal nociceptive afferent subtypes in guinea pig esophagus. Am J Physiol Gastrointest Liver Physiol. 2014;307:G471-8 pubmed publisher
    ..Pretreatment with TRPV1 antagonist AMG9810, but not acid-sensing ion channel (ASIC) inhibitor amiloride, significantly inhibited acid-induced effects in nodose and jugular C fiber...
  67. Wu Y, Gao B, Xiong Q, Wang Y, Huang D, Wu W. Acid-sensing ion channels contribute to the effect of extracellular acidosis on proliferation and migration of A549 cells. Tumour Biol. 2017;39:1010428317705750 pubmed publisher
  68. Shteinikov V, Korosteleva A, Tikhonova T, Potapieva N, Tikhonov D. Ligands of histamine receptors modulate acid-sensing ion channels. Biochem Biophys Res Commun. 2017;490:1314-1318 pubmed publisher
    ..ASIC2a were virtually insensitive to the drugs tested. We conclude that ligands of histamine receptors should also be considered as ASIC modulators.
  69. Lynagh T, Romero Rojo J, Lund C, Pless S. Molecular Basis for Allosteric Inhibition of Acid-Sensing Ion Channel 1a by Ibuprofen. J Med Chem. 2017;60:8192-8200 pubmed publisher
    ..Ibuprofen inhibits several ASIC subtypes, but certain ibuprofen derivatives show some selectivity for ASIC1a over ASIC2a and vice versa...
  70. Sudha M. Evolutionary and Neural Computing Based Decision Support System for Disease Diagnosis from Clinical Data Sets in Medical Practice. J Med Syst. 2017;41:178 pubmed publisher
    ..In this proposed Application Specific Intelligent Computing (ASIC) decision support system, a rough set based genetic algorithm is employed in pre-processing phase and a back ..
  71. Ugawa S, Ueda T, Ishida Y, Nishigaki M, Shibata Y, Shimada S. Amiloride-blockable acid-sensing ion channels are leading acid sensors expressed in human nociceptors. J Clin Invest. 2002;110:1185-90 pubmed
    ..It is generally believed that a vanilloid receptor subtype-1 (VR1) and an acid-sensing ion channel (ASIC) mediate the greater part of acid-induced nociception in mammals...
  72. Price M, Thompson R, Eshcol J, Wemmie J, Benson C. Stomatin modulates gating of acid-sensing ion channels. J Biol Chem. 2004;279:53886-91 pubmed
    ..We found that stomatin co-immunoprecipitated and co-localized with ASIC proteins in heterologous cells. Moreover, stomatin altered the function of ASIC channels...
  73. Clark E, Jovov B, Rooj A, Fuller C, Benos D. Proteolytic cleavage of human acid-sensing ion channel 1 by the serine protease matriptase. J Biol Chem. 2010;285:27130-43 pubmed publisher
    Acid-sensing ion channel 1 (ASIC1) is a H(+)-gated channel of the amiloride-sensitive epithelial Na(+) channel (ENaC)/degenerin family. ASIC1 is expressed mostly in the central and peripheral nervous system neurons...
  74. Nörenberg W, Plötz T, Sobottka H, Chubanov V, Mittermeier L, Kalwa H, et al. TRPM7 is a molecular substrate of ATP-evoked P2X7-like currents in tumor cells. J Gen Physiol. 2016;147:467-83 pubmed publisher
    ..Because TRPM7 has a critical role in controlling the intracellular Mg(2+) homeostasis and regulating tumor growth, these data imply that the proposed role of P2X7 in C6 glioma cell proliferation deserves reevaluation. ..
  75. Ilyaskin A, Diakov A, Korbmacher C, Haerteis S. Activation of the Human Epithelial Sodium Channel (ENaC) by Bile Acids Involves the Degenerin Site. J Biol Chem. 2016;291:19835-47 pubmed publisher
    ..Analysis of the known ASIC1 (acid-sensing ion channel) crystal structure suggested that bile acids may bind to the pore region at the ..
  76. Dai B, Zhu F, Chen Y, Zhou R, Wang Z, Xie Y, et al. ASIC1a Promotes Acid-Induced Autophagy in Rat Articular Chondrocytes through the AMPK/FoxO3a Pathway. Int J Mol Sci. 2017;18: pubmed publisher
    ..Taken together, these findings suggested that AMPK/FoxO3a axis plays an important role in ASIC1a-mediated autophagy in rat articular chondrocytes, which may provide novel mechanistic insight into ASIC1a effects on autophagy. ..
  77. Sun C, Wang S, Hu W. Acid-sensing ion channel 1a mediates acid-induced inhibition of matrix metabolism of rat articular chondrocytes via the MAPK signaling pathway. Mol Cell Biochem. 2018;443:81-91 pubmed publisher
    ..In conclusion, ASIC1a inhibits the expression of MMP-2/9, GAG, HYP, and TIMP-1/2 by the Ca2+-dependent P38 MAPK/c-jun and ERK/c-fos signaling pathways. ..
  78. Rodrigues V, Rocha C, Périco L, Santos R, Ohara R, Nishijima C, et al. Involvement of Opioid System, TRPM8, and ASIC Receptors in Antinociceptive Effect of Arrabidaea brachypoda (DC) Bureau. Int J Mol Sci. 2017;18: pubmed publisher
    ..1), TRPA1 (transient receptor potential ankyrin 1), TRPM8 (transient receptor potential melastatin 8), and ASIC (acid-sensing ion channel), as well as the opioidergic, glutamatergic, and supraspinal pathways...
  79. Simard J, Tarasov K, Gerzanich V. Non-selective cation channels, transient receptor potential channels and ischemic stroke. Biochim Biophys Acta. 2007;1772:947-57 pubmed
    ..described NC channels have emerged as potential participants in ischemic stroke, the acid sensing ion channel (ASIC), and the sulfonylurea receptor-1 (SUR1)-regulated NC(Ca-ATP) channel...
  80. Kapoor N, Lee W, Clark E, Bartoszewski R, McNicholas C, Latham C, et al. Interaction of ASIC1 and ENaC subunits in human glioma cells and rat astrocytes. Am J Physiol Cell Physiol. 2011;300:C1246-59 pubmed publisher
    ..To test the hypothesis that ASIC1 interacts with ?ENaC and ?ENaC at the cellular level, we have used total internal reflection fluorescence ..
  81. Lv R, He J, Fu Y, Zhang Y, Shao X, Wu L, et al. ASIC1a polymorphism is associated with temporal lobe epilepsy. Epilepsy Res. 2011;96:74-80 pubmed publisher
    ..013, p=0.004). Furthermore, the haplotype analysis revealed a significant association with TLE. The results of this study demonstrate for the first time an association between an ASC1a variant allele and TLE in a Han Chinese population. ..
  82. Sun X, Zhao D, Li Y, Sun Y, Lei X, Zhang J, et al. Regulation of ASIC1 by Ca2+/calmodulin-dependent protein kinase II in human glioblastoma multiforme. Oncol Rep. 2013;30:2852-8 pubmed publisher
    Recent studies have implicated the acid-sensing ion channel 1 (ASIC1), a proton-gated cation channel that belongs to the epithelial sodium channel (ENaC)/Degenerin family, plays an important role in glioma cell migration...
  83. Cho C, Lho Y, Ha E, Hwang I, Song K, Min B, et al. Up-regulation of acid-sensing ion channels in the capsule of the joint in frozen shoulder. Bone Joint J. 2015;97-B:824-9 pubmed publisher
    ..The expressions of ASIC1, ASIC2, and ASIC3 in the capsule were determined using the reverse transcriptase-polymerase chain reaction, ..
  84. Schuhmacher L, Smith E. Expression of acid-sensing ion channels and selection of reference genes in mouse and naked mole rat. Mol Brain. 2016;9:97 pubmed
    ..Previous studies of ASIC expression in the mammalian nervous system have often not examined all subunits, or have failed to adequately ..
  85. Yang X, Niu Y, Liu Y, Yang Y, Wang J, Cheng X, et al. The nonproton ligand of acid-sensing ion channel 3 activates mollusk-specific FaNaC channels via a mechanism independent of the native FMRFamide peptide. J Biol Chem. 2017;292:21662-21675 pubmed publisher
    ..Notably, the GMQ-gating mode is still preserved in the mammalian ASIC subfamily, whereas FMRFamide-mediated channel gating was lost during evolution...
  86. Fan S, Hao Z, Zhang L, Zhou J, Zhang Y, Tai S, et al. ASIC1a contributes to the symptom of pain in a rat model of chronic prostatitis. Asian J Androl. 2017;: pubmed publisher
    ..Our results showed that ASIC1a may contribute to the symptom of pain in patients with CP, at least partially, by regulating the p38/MAPK signaling pathway...
  87. Ji H, Jovov B, Fu J, Bishop L, Mebane H, Fuller C, et al. Up-regulation of acid-gated Na(+) channels (ASICs) by cystic fibrosis transmembrane conductance regulator co-expression in Xenopus oocytes. J Biol Chem. 2002;277:8395-405 pubmed
    ..CFTR had no effect on the pH activation of ASIC1a/2a. We conclude that wild type CFTR elevates the acid-gated Na(+) current of ASIC1a/2a in part by altering the kinetics of extracellular Na(+) interaction. ..
  88. Lin W, Ogura T, Kinnamon S. Acid-activated cation currents in rat vallate taste receptor cells. J Neurophysiol. 2002;88:133-41 pubmed
    ..taste cells share general properties with ASICs expressed in heterologous cells and sensory neurons that express ASIC subunits...
  89. Hettema J, An S, Neale M, van den Oord E, Kendler K, Chen X. Lack of association between the amiloride-sensitive cation channel 2 (ACCN2) gene and anxiety spectrum disorders. Psychiatr Genet. 2008;18:73-9 pubmed publisher
    ..this study, we examined, for the first time, the human analog of ASIC1, the amiloride-sensitive cation channel 2 (ACCN2) gene, for its association with genetic risk across a range of anxiety spectrum phenotypes...
  90. Jin W, Shen C, Jing L, Zha X, Xia J. PICK1 regulates the trafficking of ASIC1a and acidotoxicity in a BAR domain lipid binding-dependent manner. Mol Brain. 2010;3:39 pubmed publisher
    Acid-sensing ion channel 1a (ASIC1a) is the major ASIC subunit determining acid-activated currents in brain neurons. Recent studies show that ASIC1a play critical roles in acid-induced cell toxicity...
  91. O Bryant Z, Leng T, Liu M, Inoue K, Vann K, Xiong Z. Acid Sensing Ion Channels (ASICs) in NS20Y cells - potential role in neuronal differentiation. Mol Brain. 2016;9:68 pubmed publisher
    ..Reverse Transcription Polymerase Chain Reaction and Western blot revealed the presence of ASIC1 subunits in these cells...
  92. Er S, Cristofori Armstrong B, Escoubas P, Rash L. Discovery and molecular interaction studies of a highly stable, tarantula peptide modulator of acid-sensing ion channel 1. Neuropharmacology. 2017;127:185-195 pubmed publisher
    ..ASIC1a revealed that Glu177 and Arg175 in the palm region opposite ?-helix 5 play an important role in the Hm3a-ASIC1 interaction and contribute to the subtype-dependent effects of the peptide...