ApoE

Summary

Gene Symbol: ApoE
Description: apolipoprotein E
Alias: AD2, APO-E, ApoE4, LDLCQ5, LPG, apolipoprotein E, apolipoprotein E3
Species: human
Products:     ApoE

Top Publications

  1. Conway V, Allard M, Minihane A, Jackson K, Lovegrove J, Plourde M. Postprandial enrichment of triacylglycerol-rich lipoproteins with omega-3 fatty acids: lack of an interaction with apolipoprotein E genotype?. Lipids Health Dis. 2014;13:148 pubmed publisher
    ..chylomicron CM), Sf 60 - 400 (VLDL1), and Sf 20 - 60 (VLDL2) according to APOE genotype...
  2. Krimbou L, Denis M, Haidar B, Carrier M, Marcil M, Genest J. Molecular interactions between apoE and ABCA1: impact on apoE lipidation. J Lipid Res. 2004;45:839-48 pubmed
    b>Apolipoprotein E (apoE)/ABCA1 interactions were investigated in human intact fibroblasts induced with 22(R)-hydroxycholesterol and 9-cis-retinoic acid (stimulated cells)...
  3. Liang S, Steffen L, Steffen B, Guan W, Weir N, Rich S, et al. APOE genotype modifies the association between plasma omega-3 fatty acids and plasma lipids in the Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis. 2013;228:181-7 pubmed publisher
    ..acids (DHA) on plasma lipid profiles have been inconsistent but may partially depend on individual Apolipoprotein E (APOE) genotypes...
  4. Vedhachalam C, Narayanaswami V, Neto N, Forte T, Phillips M, Lund Katz S, et al. The C-terminal lipid-binding domain of apolipoprotein E is a highly efficient mediator of ABCA1-dependent cholesterol efflux that promotes the assembly of high-density lipoproteins. Biochemistry. 2007;46:2583-93 pubmed
    This study was undertaken to identify the alpha-helical domains of human apoE that mediate cellular cholesterol efflux and HDL assembly via ATP-binding cassette transporter A1 (ABCA1)...
  5. Gungor Z, Anuurad E, Enkhmaa B, Zhang W, Kim K, Berglund L. Apo E4 and lipoprotein-associated phospholipase A2 synergistically increase cardiovascular risk. Atherosclerosis. 2012;223:230-4 pubmed publisher
    b>Apolipoprotein E (apoE) has been implicated as conveying increased risk for coronary artery disease (CAD). Previous studies suggest a role of apoE as a modulator of immune response and inflammatory properties...
  6. Moore L, Brennan P, Karami S, Menashe I, Berndt S, Dong L, et al. Apolipoprotein E/C1 locus variants modify renal cell carcinoma risk. Cancer Res. 2009;69:8001-8 pubmed publisher
    ..S. study were within a regulatory region of the APOE promoter. The OR for rs8106822 A>G variant was 1.22(AG) and 1.41(GG) (P(trend) = 0.01) in the European study, 1...
  7. McKay G, Patterson C, Chakravarthy U, Dasari S, Klaver C, Vingerling J, et al. Evidence of association of APOE with age-related macular degeneration: a pooled analysis of 15 studies. Hum Mutat. 2011;32:1407-16 pubmed publisher
    ..Previous studies report inconsistent associations between AMD and apolipoprotein E (APOE), a lipid transport protein involved in low-density cholesterol modulation...
  8. Dean D, Jerskey B, Chen K, Protas H, Thiyyagura P, Roontiva A, et al. Brain differences in infants at differential genetic risk for late-onset Alzheimer disease: a cross-sectional imaging study. JAMA Neurol. 2014;71:11-22 pubmed publisher
    ..myelin water fraction (MWF) and gray matter volume (GMV) in healthy infant carriers and noncarriers of the apolipoprotein E (APOE) ε4 allele, the major susceptibility gene for late-onset AD...
  9. Jun G, Vardarajan B, Buros J, Yu C, Hawk M, Dombroski B, et al. Comprehensive search for Alzheimer disease susceptibility loci in the APOE region. Arch Neurol. 2012;69:1270-9 pubmed
    ..of Alzheimer disease (AD) with single-nucleotide polymorphisms (SNPs) in the chromosome 19 region including apolipoprotein E (APOE) and a repeat-length polymorphism in TOMM40 (poly-T, rs10524523)...

More Information

Publications223 found, 100 shown here

  1. Bergeron Sawitzke J, Gold B, Olsh A, Schlotterbeck S, Lemon K, Visvanathan K, et al. Multilocus analysis of age-related macular degeneration. Eur J Hum Genet. 2009;17:1190-9 pubmed publisher
    ..factor B (CFB), age-related maculopathy susceptibility (ARMS2), HtrA serine peptidase 1 (HTRA1), and apolipoprotein E (APOE)...
  2. Frikke Schmidt R, Sing C, Nordestgaard B, Steffensen R, Tybjaerg Hansen A. Subsets of SNPs define rare genotype classes that predict ischemic heart disease. Hum Genet. 2007;120:865-77 pubmed
    ..In this study we determined the utility of exonic and 5' SNPs in apolipoprotein E (APOE) and lipoprotein lipase (LPL) when considered singly and in combination for predicting incidence of IHD ..
  3. Heeren J, Grewal T, Laatsch A, Becker N, Rinninger F, Rye K, et al. Impaired recycling of apolipoprotein E4 is associated with intracellular cholesterol accumulation. J Biol Chem. 2004;279:55483-92 pubmed
    ..Since epidemiological data showed that apoE3 and apoE4 have differential effects on HDL metabolism, we investigated whether the intracellular processing of TRL-derived ..
  4. Ken Dror G, Talmud P, Humphries S, Drenos F. APOE/C1/C4/C2 gene cluster genotypes, haplotypes and lipid levels in prospective coronary heart disease risk among UK healthy men. Mol Med. 2010;16:389-99 pubmed publisher
    The role of common APOE variants on plasma lipids, particularly low density lipoprotein (LDL) levels, and coronary heart disease (CHD) risk is well known; the influence of variation in the other nearby apolipoprotein genes APOC1, APOC4 ..
  5. Davies G, Harris S, Reynolds C, Payton A, Knight H, Liewald D, et al. A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing. Mol Psychiatry. 2014;19:76-87 pubmed publisher
    ..This result was replicated in a meta-analysis of three independent Swedish cohorts (P=2.41 × 10(-6)). An Apolipoprotein E (APOE) haplotype (adjacent to TOMM40), previously associated with cognitive ageing, had a significant effect ..
  6. Seshadri S, Fitzpatrick A, Ikram M, Destefano A, Gudnason V, Boada M, et al. Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA. 2010;303:1832-40 pubmed publisher
    ..with AD in this independent sample, they did not improve the ability of a model that included age, sex, and APOE to predict incident AD (improvement in area under the receiver operating characteristic curve from 0.847 to 0...
  7. Schupf N, Barral S, Perls T, Newman A, Christensen K, Thyagarajan B, et al. Apolipoprotein E and familial longevity. Neurobiol Aging. 2013;34:1287-91 pubmed publisher
    Exceptional longevity is associated with substantial heritability. The ε4 allele in apolipoprotein E and the linked G allele in rs2075650 of TOMM40 have been associated with increased mortality and the ε2 allele with decreased ..
  8. Tsuang D, Leverenz J, Lopez O, Hamilton R, Bennett D, Schneider J, et al. APOE ?4 increases risk for dementia in pure synucleinopathies. JAMA Neurol. 2013;70:223-8 pubmed publisher
    To test for an association between the apolipoprotein E (APOE) ?4 allele and dementias with synucleinopathy. Genetic case-control association study. Academic research...
  9. Elliott P, Chambers J, Zhang W, Clarke R, Hopewell J, Peden J, et al. Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease. JAMA. 2009;302:37-48 pubmed publisher
    ..9%; P = 1.3 x 10(-38)), rs1183910 in HNF1A (-13.8%; 95% CI, -16.6% to -10.9%; P = 1.9 x 10(-18)), and rs4420638 in APOE-CI-CII (-21.8%; 95% CI, -25.3% to -18.1%; P = 8.1 x 10(-26))...
  10. Minagawa H, Gong J, Jung C, Watanabe A, Lund Katz S, Phillips M, et al. Mechanism underlying apolipoprotein E (ApoE) isoform-dependent lipid efflux from neural cells in culture. J Neurosci Res. 2009;87:2498-508 pubmed publisher
    We determined the molecular mechanisms underlying apolipoprotein E (ApoE)-isoform-dependent lipid efflux from neurons and ApoE-deficient astrocytes in culture. The ability of ApoE3 to induce lipid efflux was 2.5- to 3...
  11. Maloney B, Ge Y, Petersen R, Hardy J, Rogers J, Pérez Tur J, et al. Functional characterization of three single-nucleotide polymorphisms present in the human APOE promoter sequence: Differential effects in neuronal cells and on DNA-protein interactions. Am J Med Genet B Neuropsychiatr Genet. 2010;153B:185-201 pubmed publisher
    Variations in levels of apolipoprotein E (ApoE) have been tied to the risk and progression of Alzheimer's disease (AD)...
  12. Morgan E, Woods S, Letendre S, Franklin D, Bloss C, Goate A, et al. Apolipoprotein E4 genotype does not increase risk of HIV-associated neurocognitive disorders. J Neurovirol. 2013;19:150-6 pubmed publisher
    ..a cross-sectional, observational study to evaluate the hypothesis that HIV-seropositive (HIV+) apolipoprotein E4 (APOE4) carriers are at increased risk for HIV-associated neurocognitive disorders (HAND) compared to APOE4 noncarriers ..
  13. Chiang G, Insel P, Tosun D, Schuff N, Truran Sacrey D, Raptentsetsang S, et al. Impact of apolipoprotein E4-cerebrospinal fluid β-amyloid interaction on hippocampal volume loss over 1 year in mild cognitive impairment. Alzheimers Dement. 2011;7:514-20 pubmed publisher
    ..Apolipoprotein ɛ4 (APOE ɛ4), a genetic risk factor for Alzheimer's disease, is also known to be associated with hippocampal volume loss...
  14. Bonner Jackson A, Okonkwo O, Tremont G. Apolipoprotein E ε2 and functional decline in amnestic mild cognitive impairment and Alzheimer disease. Am J Geriatr Psychiatry. 2012;20:584-93 pubmed publisher
    Recent work has demonstrated the potentially protective effects of the apolipoprotein E (APOE) ε2 allele on cognitive functioning in individuals at risk for developing Alzheimer disease...
  15. Hollingworth P, Sweet R, Sims R, Harold D, Russo G, Abraham R, et al. Genome-wide association study of Alzheimer's disease with psychotic symptoms. Mol Psychiatry. 2012;17:1316-27 pubmed publisher
    ..Aside from the apolipoprotein E (APOE) locus, the strongest evidence for association was observed in an intergenic region on chromosome 4 (..
  16. Hubacek J, Bloudickova S, Kubinova R, Pikhart H, Viklicky O, Bobak M. Apolipoprotein E polymorphism in hemodialyzed patients and healthy controls. Biochem Genet. 2009;47:688-93 pubmed publisher
    A possible association between end-stage renal disease (ESRD) and apolipoprotein E (APOE) polymorphism was found in some but not all studies...
  17. Federoff M, Jimenez Rolando B, Nalls M, Singleton A. A large study reveals no association between APOE and Parkinson's disease. Neurobiol Dis. 2012;46:389-92 pubmed publisher
    Research focusing on the role of APOE in Parkinson's disease (PD) has been largely inconclusive, creating a broad discrepancy in association studies...
  18. Sundar P, Feingold E, Minster R, DeKosky S, Kamboh M. Gender-specific association of ATP-binding cassette transporter 1 (ABCA1) polymorphisms with the risk of late-onset Alzheimer's disease. Neurobiol Aging. 2007;28:856-62 pubmed
    ..Our data suggest a gender-specific and APOE and UBQLN1 independent association between the ABCA1/R219K polymorphism and LOAD.
  19. Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere M, et al. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet. 2009;41:1088-93 pubmed publisher
    ..In stage 1 (3,941 cases and 7,848 controls), we replicated the established association with the apolipoprotein E (APOE) locus (most significant SNP, rs2075650, P = 1...
  20. Schiepers O, Harris S, Gow A, Pattie A, Brett C, Starr J, et al. APOE E4 status predicts age-related cognitive decline in the ninth decade: longitudinal follow-up of the Lothian Birth Cohort 1921. Mol Psychiatry. 2012;17:315-24 pubmed publisher
    Carriers of the APOE E4 allele have an increased risk of developing Alzheimer's disease. However, it is less clear whether APOE E4 status may also be involved in non-pathological cognitive ageing...
  21. Chen J, Li Q, Wang J. Topology of human apolipoprotein E3 uniquely regulates its diverse biological functions. Proc Natl Acad Sci U S A. 2011;108:14813-8 pubmed publisher
    Human apolipoprotein E (apoE) is one of the major determinants in lipid transport, playing a critical role in atherosclerosis and other diseases...
  22. Song Q, Chen P, Liu Q. Role of the APOE ?2/?3/?4 polymorphism in the development of primary open-angle glaucoma: evidence from a comprehensive meta-analysis. PLoS ONE. 2013;8:e82347 pubmed publisher
    Primary open-angle glaucoma (POAG) is one of the leading causes of blindness worldwide. The association between the APOE ?2/?3/?4 polymorphism and the risk of POAG has been widely reported, but the results of previous studies remain ..
  23. Thelma B, Juyal R, Dodge H, Pandav R, Chandra V, Ganguli M. APOE polymorphism in a rural older population-based sample in India. Hum Biol. 2001;73:135-44 pubmed
    ..We determined the distribution of apolipoprotein E genotype (APOE) and allele frequencies for a large, well-defined, representative, rural, population-based ..
  24. Wang H, Fung H, Hsu W, Wu Y, Lin J, Ro L, et al. Apolipoprotein E, angiotensin-converting enzyme and kallikrein gene polymorphisms and the risk of Alzheimer's disease and vascular dementia. J Neural Transm (Vienna). 2006;113:1499-509 pubmed
    ..In this study, odd ratios (ORs) and 95% confidence intervals (CIs) for apolipoprotein E (APOE), angiotensin-converting enzyme (ACE), and kallikrein (KLK1) polymorphisms were computed to test their ..
  25. Silbert B, Evered L, Scott D, Cowie T. The apolipoprotein E epsilon4 allele is not associated with cognitive dysfunction in cardiac surgery. Ann Thorac Surg. 2008;86:841-7 pubmed publisher
    The plasma protein apolipoprotein E (APOE) is a risk factor for degenerative cognitive decline manifested by mild cognitive impairment and later by Alzheimer's disease...
  26. Araki S, Koya D, Makiishi T, Sugimoto T, Isono M, Kikkawa R, et al. APOE polymorphism and the progression of diabetic nephropathy in Japanese subjects with type 2 diabetes: results of a prospective observational follow-up study. Diabetes Care. 2003;26:2416-20 pubmed
    The aim of this study is to clarify the conflicting results of the epsilon2/epsilon3/epsilon4 APOE polymorphism as a risk factor on diabetic nephropathy by a cohort study...
  27. Singh P, Singh M, Mastana S. APOE distribution in world populations with new data from India and the UK. Ann Hum Biol. 2006;33:279-308 pubmed
    ..b>Apolipoprotein E genotypes were determined in four population groups (Punjabi Sikhs, Punjabi Hindus, Maria Gonds and Koch, ..
  28. Dennis N, Browndyke J, Stokes J, Need A, Burke J, Welsh Bohmer K, et al. Temporal lobe functional activity and connectivity in young adult APOE varepsilon4 carriers. Alzheimers Dement. 2010;6:303-11 pubmed publisher
    We sought to determine if the APOE epsilon4 allele influences both the functional activation and connectivity of the medial temporal lobes (MTLs) during successful memory encoding in young adults. Twenty-four healthy young adults, i.e...
  29. Mahley R, Rall S. Apolipoprotein E: far more than a lipid transport protein. Annu Rev Genomics Hum Genet. 2000;1:507-37 pubmed
    ..ApoE is a polymorphic protein arising from three alleles at a single gene locus. The three major isoforms, apoE4, apoE3, and apoE2, differ from one another only by single amino acid substitutions, yet these changes have ..
  30. Wilson R, Schneider J, Barnes L, Beckett L, Aggarwal N, Cochran E, et al. The apolipoprotein E epsilon 4 allele and decline in different cognitive systems during a 6-year period. Arch Neurol. 2002;59:1154-60 pubmed
    Impairment of episodic memory is an early and defining feature of Alzheimer disease (AD). The apolipoprotein E (APOE) epsilon 4 allele is known to influence risk of AD but it has been difficult to establish whether it affects episodic ..
  31. Filippini N, MacIntosh B, Hough M, Goodwin G, Frisoni G, Smith S, et al. Distinct patterns of brain activity in young carriers of the APOE-epsilon4 allele. Proc Natl Acad Sci U S A. 2009;106:7209-14 pubmed publisher
    The APOE epsilon4 allele is a risk factor for late-life pathological changes that is also associated with anatomical and functional brain changes in middle-aged and elderly healthy subjects...
  32. Thompson J, Man M, Johnson K, Wood L, Lira M, Lloyd D, et al. An association study of 43 SNPs in 16 candidate genes with atorvastatin response. Pharmacogenomics J. 2005;5:352-8 pubmed
    ..The magnitude of all the differences found is sufficiently small that genetic data from these genes should not influence clinical decisions on statin administration. ..
  33. Kurz M, Dekomien G, Nilsen O, Larsen J, Aarsland D, Alves G. APOE alleles in Parkinson disease and their relationship to cognitive decline: a population-based, longitudinal study. J Geriatr Psychiatry Neurol. 2009;22:166-70 pubmed publisher
    b>Apolipoprotein E gene alleles have been linked to various cardiovascular and neurodegenerative disorders...
  34. Bazzaz J, Nazari M, Nazem H, Amiri P, Fakhrzadeh H, Heshmat R, et al. Apolipoprotein E gene polymorphism and total serum cholesterol level in Iranian population. J Postgrad Med. 2010;56:173-5 pubmed publisher
    b>Apolipoprotein E (APOE) is known as a major regulator of blood lipid levels in humans. A number of APOE gene allelic variants have been reported including E2, E3 and E4...
  35. Becher J, Keeling J, McIntosh N, Wyatt B, Bell J. The distribution of apolipoprotein E alleles in Scottish perinatal deaths. J Med Genet. 2006;43:414-8 pubmed
    The apolipoprotein E (ApoE) polymorphism has been well studied in the adult human population, in part because the e4 allele is a known risk factor for Alzheimer's disease...
  36. Westlye E, Hodneland E, Haász J, Espeseth T, Lundervold A, Lundervold A. Episodic memory of APOE ?4 carriers is correlated with fractional anisotropy, but not cortical thickness, in the medial temporal lobe. Neuroimage. 2012;63:507-16 pubmed publisher
    The ?4 allele of apolipoprotein E (apoE, protein; APOE, gene) is the most important genetic risk factor for the development of Alzheimer's disease (AD)...
  37. Louko A, Vilkki J, Niskakangas T. ApoE genotype and cognition after subarachnoid haemorrhage: a longitudinal study. Acta Neurol Scand. 2006;114:315-9 pubmed
    ..Presence of the epsilon4 allele poses a minor risk for late cognitive impairment after the subacute phase of aneurysmal SAH. ..
  38. Andersson M, Sjölander A, Andreasen N, Minthon L, Hansson O, Bogdanovic N, et al. Kinesin gene variability may affect tau phosphorylation in early Alzheimer's disease. Int J Mol Med. 2007;20:233-9 pubmed
    ..The rs8702 polymorphism did not influence risk of AD (p=0.46). However, rs8702 interacted with APOE epsilon 4 carrier status in AD (p=0...
  39. Hu P, Qin Y, Jing C, Lei F, Chen P, Li M. Association of polymorphisms at restriction enzyme recognition sites of apolipoprotein B and E gene with dyslipidemia in children undergoing primary nephrotic syndrome. Mol Biol Rep. 2009;36:1015-21 pubmed publisher
    ..To investigate the association of apolipoprotein B (apoB) and E (apoE) genetic polymorphisms (Xba I, EcoR I, Msp I, and Hha I) with parameters describing the serum lipid profiles in ..
  40. van den Maagdenberg A, Weng W, de Bruijn I, De Knijff P, Funke H, Smelt A, et al. Characterization of five new mutants in the carboxyl-terminal domain of human apolipoprotein E: no cosegregation with severe hyperlipidemia. Am J Hum Genet. 1993;52:937-46 pubmed
    Assessment of the apolipoprotein E (apoE) phenotype by isoelectric focusing of both hyperlipidemic and normolipidemic individuals identified five new variants...
  41. Ji Y, Gong Y, Gan W, Beach T, Holtzman D, Wisniewski T. Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer's disease patients. Neuroscience. 2003;122:305-15 pubmed
    ..A role for apoE is implicated in regeneration of synaptic circuitry after neural injury. The apoE4 allele is a major risk factor for late-onset familial and sporadic Alzheimer's disease (AD) and is associated with ..
  42. Potkin S, Guffanti G, Lakatos A, Turner J, Kruggel F, Fallon J, et al. Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease. PLoS ONE. 2009;4:e6501 pubmed publisher
    With the exception of APOE epsilon4 allele, the common genetic risk factors for sporadic Alzheimer's Disease (AD) are unknown...
  43. Liberopoulos E, Miltiadous G, Athyros V, Ganotakis M, Cariolou M, Bairaktari E, et al. Effect of apolipoprotein E polymorphism on serum uric acid levels in healthy subjects. J Investig Med. 2005;53:116-22 pubmed publisher
    We have previously shown that apolipoprotein E (apo E-) polymorphism may affect serum creatinine concentration and predicted glomerular filtration rate in healthy individuals...
  44. Hu P, Qin Y, Lei F, Pei J, Hu B, Lu L. Variable frequencies of apolipoprotein E genotypes and its effect on serum lipids in the Guangxi Zhuang and Han children. Int J Mol Sci. 2011;12:5604-15 pubmed publisher
    ..Studies of apolipoprotein E (APOE) polymorphism in adults suggest the lower frequencies of E4 allele and E4/E4 genotype may account, in ..
  45. Butler W, Ryan P, Roberts Thomson I. Metabolic genotypes and risk for colorectal cancer. J Gastroenterol Hepatol. 2001;16:631-5 pubmed
    ..1 (NAT1), NAT2, cytochrome P450 1A1 (CYP1A1), CYP2D6, CYP2E1, glutathione S-transferase M1 (GSTM1), GSTT1 and apolipoprotein E were compared in 219 white adults with sporadic colorectal cancer and 200 white controls attending for blood ..
  46. Qiu C, Winblad B, Fastbom J, Fratiglioni L. Combined effects of APOE genotype, blood pressure, and antihypertensive drug use on incident AD. Neurology. 2003;61:655-60 pubmed
    To study the hypotheses that APOE-epsilon4 allele may interact with blood pressure to affect Alzheimer's disease (AD) occurrence and that antihypertensive therapy could modify such an effect...
  47. Tursen U, Kaya T, Eskandari G, Bocekli E, Muslu N, Camdeviren H, et al. Apolipoprotein E gene polymorphism and serum lipids in patients with superficial fungal disease. Yonsei Med J. 2004;45:375-9 pubmed
    ..In this study, Apolipoprotein E (ApoE) polymorphism and lipoprotein cholesterol concentrations were compared between 42 patients with ..
  48. Fleisher A, Grundman M, Jack C, Petersen R, Taylor C, Kim H, et al. Sex, apolipoprotein E epsilon 4 status, and hippocampal volume in mild cognitive impairment. Arch Neurol. 2005;62:953-7 pubmed
    ..The presence of the apolipoprotein E epsilon4 (APOE*E4) allele has been associated with greater hippocampal atrophy in women than in men with ..
  49. Wittrup H, Andersen R, Tybjaerg Hansen A, Jensen G, Nordestgaard B. Combined analysis of six lipoprotein lipase genetic variants on triglycerides, high-density lipoprotein, and ischemic heart disease: cross-sectional, prospective, and case-control studies from the Copenhagen City Heart Study. J Clin Endocrinol Metab. 2006;91:1438-45 pubmed
    ..5 (CI, 1.2-2.1). 291Ser and 447Ter did not change IHD risk. Stratified for apolipoprotein E genotype, the odds ratios for IHD in 9Asn (with -93G) heterozygotes and homozygotes combined vs...
  50. Tascilar N, Dursun A, Ankarali H, Mungan G, Sumbuloglu V, Ekem S, et al. Relationship of apoE polymorphism with lipoprotein(a), apoA, apoB and lipid levels in atherosclerotic infarct. J Neurol Sci. 2009;277:17-21 pubmed publisher
    b>Apolipoprotein E (apoE) polymorphism is suggested to be a risk factor in stroke in some populations, either by affecting lipid parameters or independently. Its effect on lipoprotein(a) [Lp(a)] is not known...
  51. Viitanen L, Pihlajamaki J, Miettinen R, Kärkkäinen P, Vauhkonen I, Halonen P, et al. Apolipoprotein E gene promoter (-219G/T) polymorphism is associated with premature coronary heart disease. J Mol Med (Berl). 2001;79:732-7 pubmed
    ..Additionally, when the two apo E gene polymorphisms were combined, affected siblings and probands had a higher frequency of the -219T allele and ..
  52. Tiraboschi P, Hansen L, Masliah E, Alford M, Thal L, Corey Bloom J. Impact of APOE genotype on neuropathologic and neurochemical markers of Alzheimer disease. Neurology. 2004;62:1977-83 pubmed
    The APOE epsilon4 allele has emerged as a major genetic factor for Alzheimer disease (AD), and its presence has been associated with an increase in beta-amyloid senile plaques (SPs) and neuritic plaques (NPs)...
  53. Atabek M, Ozkul Y, Eklioğlu B, Kurtoglu S, Baykara M. Association between apolipoprotein E polymorphism and subclinic atherosclerosis in patients with type 1 diabetes mellitus. J Clin Res Pediatr Endocrinol. 2012;4:8-13 pubmed publisher
    The most important cause of morbidity and mortality in type 1 diabetes mellitus (DM) is atherosclerosis. Apolipoprotein E (Apo E) polymorphism is accused of being the genetic risk factor for atherosclerosis...
  54. Souza D, de Godoy M, Hotta J, Tajara E, Brandao A, Pinheiro Júnior S, et al. Association of apolipoprotein E polymorphism in late-onset Alzheimer's disease and vascular dementia in Brazilians. Braz J Med Biol Res. 2003;36:919-23 pubmed
    The genetic basis for dementias is complex. A common polymorphism in the apolipoprotein E (APOE) gene is considered to be the major risk factor in families with sporadic and late-onset Alzheimer's disease as well as in the general ..
  55. Buchman A, Boyle P, Wilson R, Beck T, Kelly J, Bennett D. Apolipoprotein E e4 allele is associated with more rapid motor decline in older persons. Alzheimer Dis Assoc Disord. 2009;23:63-9 pubmed
    We tested the hypothesis that apolipoprotein E allele status predicts the rate of motor decline in the elderly. Eight hundred seventy-six older participants without dementia underwent baseline and annual motor testing for up to 10 years...
  56. Panizzon M, Hauger R, Dale A, Eaves L, Eyler L, Fischl B, et al. Testosterone modifies the effect of APOE genotype on hippocampal volume in middle-aged men. Neurology. 2010;75:874-80 pubmed publisher
    The APOE epsilon4 allele is an established risk factor for Alzheimer disease (AD), yet findings are mixed for how early its effects are manifest...
  57. Boulenouar H, Médiène Benchekor S, Meroufel D, Lardjam Hetraf S, Ouhaibi Djellouli H, Hermant X, et al. Impact of APOE gene polymorphisms on the lipid profile in an Algerian population. Lipids Health Dis. 2013;12:155 pubmed publisher
    The importance of apolipoprotein E (APOE) in lipid and lipoprotein metabolism is well established. However, the impact of APOE polymorphisms has never been investigated in an Algerian population...
  58. Zeleny M, Swertfeger D, Weisgraber K, Hui D. Distinct apolipoprotein E isoform preference for inhibition of smooth muscle cell migration and proliferation. Biochemistry. 2002;41:11820-3 pubmed
    The current study compared the effectiveness of the various human apolipoprotein E (apoE) isoforms in inhibiting platelet-derived growth factor- (PDGF-) stimulated smooth muscle cell proliferation and migration...
  59. Kohnke H, Sörlin K, Granath G, Wadelius M. Warfarin dose related to apolipoprotein E (APOE) genotype. Eur J Clin Pharmacol. 2005;61:381-8 pubmed
    ..b>Apolipoprotein E plays a central role in the uptake of the lipid-soluble vitamin K...
  60. Zhou W, Xu D, Peng X, Zhang Q, Jia J, Crutcher K. Meta-analysis of APOE4 allele and outcome after traumatic brain injury. J Neurotrauma. 2008;25:279-90 pubmed publisher
    There is conflicting evidence regarding a possible association between the apolipoprotein E4 (APOE4) allele and the consequences of traumatic brain injury (TBI)...
  61. Gallegos Arreola M, Figuera L, Ortiz G, Jiménez Gil F, Ramírez Vega J, Ruiz Sandoval J, et al. Apolipoprotein E genotypes in Mexican patients with Parkinson's disease. Dis Markers. 2009;27:225-30 pubmed publisher
    The association of the apolipoprotein (Apo E) -epsilon4 allele to neurodegenerative diseases such as Parkinson's disease (PD) has been analyzed in several studies...
  62. Sullivan P, Mezdour H, Aratani Y, Knouff C, Najib J, Reddick R, et al. Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis. J Biol Chem. 1997;272:17972-80 pubmed
    ..We found, however, notable differences in the distribution of plasma lipoproteins and apolipoprotein E between the two groups: beta-migrating lipoproteins and plasma apoB100 levels are decreased in the 3/3 mice, ..
  63. Asakimori Y, Yorioka N, Tanaka J, Kohno N. Effect of polymorphism of the endothelial nitric oxide synthase and apolipoprotein E genes on carotid atherosclerosis in hemodialysis patients. Am J Kidney Dis. 2003;41:822-32 pubmed
    ..We investigated the relationship between endothelial NO synthase (eNOS) gene polymorphism, apolipoprotein E (apoE) polymorphism, and carotid atherosclerosis in 163 hemodialysis patients with nondiabetic nephropathy...
  64. Zhu S, Wang Z, Wu X, Shu Y, Lu D. Apolipoprotein E polymorphism is associated with lower extremity deep venous thrombosis: color-flow Doppler ultrasound evaluation. Lipids Health Dis. 2014;13:21 pubmed publisher
    b>Apolipoprotein E (apoE) is a member of apolipoprotein family, and its gene polymorphisms seem to have some impact among patients with cardiovascular disease...
  65. Ewbank D. Mortality differences by APOE genotype estimated from demographic synthesis. Genet Epidemiol. 2002;22:146-55 pubmed
    The 4 allele of apolipoprotein E (APOE) is associated with increased risk of two major causes of death in low-mortality populations: ischemic heart disease and Alzheimer's disease. It is less common among centenarians than at younger ages...
  66. Bour A, Grootendorst J, Vogel E, Kelche C, Dodart J, Bales K, et al. Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks. Behav Brain Res. 2008;193:174-82 pubmed publisher
    ..These mice express either the human apoE3 or apoE4 gene under the control of endogenous murine apoE regulatory sequences, resulting in physiological expression of h-..
  67. Plourde M, Vohl M, Vandal M, Couture P, Lemieux S, Cunnane S. Plasma n-3 fatty acid response to an n-3 fatty acid supplement is modulated by apoE epsilon4 but not by the common PPAR-alpha L162V polymorphism in men. Br J Nutr. 2009;102:1121-4 pubmed publisher
    The risk of Alzheimer's disease is increased for carriers of apoE4 (E4) or the PPAR-alpha L162V polymorphism (L162V), but it is decreased in fish and seafood consumers...
  68. Viiri L, Loimaala A, Nenonen A, Islam S, Vuori I, Karhunen P, et al. The association of the apolipoprotein E gene promoter polymorphisms and haplotypes with serum lipid and lipoprotein concentrations. Atherosclerosis. 2005;179:161-7 pubmed
    b>Apolipoprotein E (ApoE) is known to modulate lipoprotein transport and metabolism. The common APOE epsilon2/epsilon3/epsilon4 polymorphism explains part of the variation in plasma cholesterol levels...
  69. Corder E, Blennow K, Prince J. Genetic susceptibility sets for Alzheimer's disease identified from diverse candidate loci. Rejuvenation Res. 2008;11:667-79 pubmed publisher
    Alzheimer's disease (AD) has been demonstrated to be associated with gene variants of APOE, but numerous additional candidate loci exist with varying levels of statistical support...
  70. Lee D, Kim K, Kim B, Kim K, Joo N. ApoE polymorphism may determine low-density lipoprotein cholesterol level in association with obesity and metabolic syndrome in postmenopausal Korean women. Yonsei Med J. 2011;52:429-34 pubmed
    ..Six ApoE isoforms were found, ApoE2 [E2/2 (n=1), E2/3 (n=54), E2/4 (n=14)], ApoE3 (E3/3, n=200), ApoE4 [E3/4 (n=55), and E4/4 (n=8)]...
  71. Schaefer E, Gregg R, Ghiselli G, Forte T, Ordovas J, Zech L, et al. Familial apolipoprotein E deficiency. J Clin Invest. 1986;78:1206-19 pubmed
    ..Homozygotes had only trace amounts of plasma apoE, and accumulations of apoB-48 and apoA-IV in VLDL, IDL, and low density lipoproteins...
  72. Ewbank D. The APOE gene and differences in life expectancy in Europe. J Gerontol A Biol Sci Med Sci. 2004;59:16-20 pubmed
    Common alleles of the apolipoprotein-E gene (APOE) are associated with different risks of ischemic heart disease, Alzheimer's disease, and other chronic conditions in European populations...
  73. Anoop S, Misra A, Meena K, Luthra K. Apolipoprotein E polymorphism in cerebrovascular & coronary heart diseases. Indian J Med Res. 2010;132:363-78 pubmed
    The role of apolipoprotein E (apo E) in lipid metabolism and cholesterol transport is well established. About 14 per cent of the variation in plasma cholesterol levels is attributed to polymorphisms in APO E gene (APO E)...
  74. Kumar N, Liestøl K, Løberg E, Reims H, Brorson S, Maehlen J. The apolipoprotein E polymorphism and cardiovascular diseases--an autopsy study. Cardiovasc Pathol. 2012;21:461-9 pubmed publisher
    Numerous studies have addressed the association between the apolipoprotein E polymorphism and cardiovascular disease, but only a few reports are based on findings at autopsy...
  75. Gilbert P, Murphy C. The effect of the ApoE epsilon4 allele on recognition memory for olfactory and visual stimuli in patients with pathologically confirmed Alzheimer's disease, probable Alzheimer's disease, and healthy elderly controls. J Clin Exp Neuropsychol. 2004;26:779-94 pubmed
    ..The results of the present study offer new insight into how recognition memory is affected by AD, the epsilon4 allele, and the modality of the stimulus to be remembered. ..
  76. Tsai S, Yu Y, Hong C. Personality traits in young female apolipoprotein E (apoE) epsilon4 and non-epsilon4 carriers. Am J Med Genet B Neuropsychiatr Genet. 2004;124B:58-60 pubmed
    b>Apolipoprotein E (apoE) is the major brain apolipoprotein, and is related to the functional integrity of the central nervous system...
  77. Hayden K, Zandi P, Lyketsos C, Tschanz J, Norton M, Khachaturian A, et al. Apolipoprotein E genotype and mortality: findings from the Cache County Study. J Am Geriatr Soc. 2005;53:935-42 pubmed
    To evaluate the association between apolipoprotein E (apo E) epsilon4 and mortality, the population attributable risk for mortality with epsilon4, and relative contributions of cardiovascular disease (CVD) and Alzheimer's disease (AD)...
  78. Kristiansson K, Perola M, Tikkanen E, Kettunen J, Surakka I, Havulinna A, et al. Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. Circ Cardiovasc Genet. 2012;5:242-9 pubmed publisher
    ..We found little evidence for pleiotropy linking dyslipidemia and obesity to the other MetS component traits, such as hypertension and glucose intolerance. ..
  79. Kim S, Swaminathan S, Shen L, Risacher S, Nho K, Foroud T, et al. Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort. Neurology. 2011;76:69-79 pubmed publisher
    ..Four SNPs in the regions of the APOE, LOC100129500, TOMM40, and EPC2 genes reached genome-wide significance for associations with one or more CSF ..
  80. Baird P, Richardson A, Robman L, Dimitrov P, Tikellis G, McCarty C, et al. Apolipoprotein (APOE) gene is associated with progression of age-related macular degeneration (AMD). Hum Mutat. 2006;27:337-42 pubmed
    ..526C>T of reference sequence NM_000041.2) of the apolipoprotein (APOE) gene were found to be strongly associated with disease with a significant 4...
  81. Leoni V. The effect of apolipoprotein E (ApoE) genotype on biomarkers of amyloidogenesis, tau pathology and neurodegeneration in Alzheimer's disease. Clin Chem Lab Med. 2011;49:375-83 pubmed publisher
    The presence of the ?4 allele in apolipoprotein E (ApoE) represents the most important genetic risk factor for late onset sporadic Alzheimer's disease (AD), together with age and mid-life hypercholesterolemia...
  82. Sanna S, Li B, Mulas A, Sidore C, Kang H, Jackson A, et al. Fine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritability. PLoS Genet. 2011;7:e1002198 pubmed publisher
    ..To assess this hypothesis, we re-examined 7 genes (APOE, APOC1, APOC2, SORT1, LDLR, APOB, and PCSK9) in 5 loci associated with low-density lipoprotein cholesterol (LDL-C) ..
  83. Drory V, Birnbaum M, Korczyn A, Chapman J. Association of APOE epsilon4 allele with survival in amyotrophic lateral sclerosis. J Neurol Sci. 2001;190:17-20 pubmed
    b>APOE epsilon4 allele is associated with poorer outcome in degenerative neurological diseases. Its role in amyotrophic lateral sclerosis (ALS) is still unclear...
  84. Belinson H, Kariv Inbal Z, Kayed R, Masliah E, Michaelson D. Following activation of the amyloid cascade, apolipoprotein E4 drives the in vivo oligomerization of amyloid-? resulting in neurodegeneration. J Alzheimers Dis. 2010;22:959-70 pubmed publisher
    ..Here, we examined the hypothesis that apolipoprotein E4 (ApoE4), the most prevalent genetic risk factor for AD, triggers the accumulation of intraneuronal oligomerized A? ..
  85. Han M, Schellenberg G, Wang L. Genome-wide association reveals genetic effects on human A?42 and ? protein levels in cerebrospinal fluids: a case control study. BMC Neurol. 2010;10:90 pubmed publisher
    ..common and highly heritable with many genes and gene variants associated with AD in one or more studies, including APOE ?2/?3/?4...
  86. Russ C, Powell J, Zhao J, Baker M, Hutton M, Crawford F, et al. The microtubule associated protein Tau gene and Alzheimer's disease--an association study and meta-analysis. Neurosci Lett. 2001;314:92-6 pubmed
    ..haplotype of the microtubule associated protein tau gene and Alzheimer's disease (AD) in synergy with apolipoprotein E (APOE) epsilon 4 status. However these findings have not been consistently replicated...
  87. Lemaitre H, Crivello F, Dufouil C, Grassiot B, Tzourio C, Alperovitch A, et al. No epsilon4 gene dose effect on hippocampal atrophy in a large MRI database of healthy elderly subjects. Neuroimage. 2005;24:1205-13 pubmed
    The effect of ApoE genotype on grey matter (GM) atrophy was studied on a cohort of 750 healthy elderly volunteers (age range 63-75 years)...
  88. Inbar D, Belinson H, Rosenman H, Michaelson D. Possible role of tau in mediating pathological effects of apoE4 in vivo prior to and following activation of the amyloid cascade. Neurodegener Dis. 2010;7:16-23 pubmed publisher
    ..thiorphan into the brain induces the accumulation of Abeta in hippocampal CA1 neurons and septal neurons in apoE4 knock-in mice but not in mice that express the corresponding Alzheimer's disease benign isoform apoE3...