APOA5

Summary

Gene Symbol: APOA5
Description: apolipoprotein A5
Alias: APOAV, RAP3, apolipoprotein A-V, apo-AV, apolipoprotein A-V precursor variant 3, regeneration-associated protein 3
Species: human
Products:     APOA5

Top Publications

  1. Moreno Luna R, Perez Jimenez F, Marin C, Perez Martinez P, Gomez P, Jimenez Gomez Y, et al. Two independent apolipoprotein A5 haplotypes modulate postprandial lipoprotein metabolism in a healthy Caucasian population. J Clin Endocrinol Metab. 2007;92:2280-5 pubmed
    Apolipoprotein A5 (APOA5) plays an important role in plasma triacylglycerol (TG) homeostasis. Five polymorphisms (1131T>C, c.-3A>G, c.56C>G, IVS3+476G>A, and c...
  2. Nilsson S, Christensen S, Raarup M, Ryan R, Nielsen M, Olivecrona G. Endocytosis of apolipoprotein A-V by members of the low density lipoprotein receptor and the VPS10p domain receptor families. J Biol Chem. 2008;283:25920-7 pubmed publisher
    ..We conclude that apoA-V binds to receptors possessing LDL-A repeats and Vsp10p domains and that apoA-V is internalized into cells via these receptors. This could be a mechanism by which apoA-V modulates lipoprotein metabolism in vivo. ..
  3. Hahne P, Krempler F, Schaap F, Soyal S, Höffinger H, Miller K, et al. Determinants of plasma apolipoprotein A-V and APOA5 gene transcripts in humans. J Intern Med. 2008;264:452-62 pubmed publisher
    ..We therefore ascertained determinants of hepatic APOA5 transcript and apoAV plasma levels in humans...
  4. AshokKumar M, Subhashini N, SaiBabu R, Ramesh A, Cherian K, Emmanuel C. Genetic variants on apolipoprotein gene cluster influence triglycerides with a risk of coronary artery disease among Indians. Mol Biol Rep. 2010;37:521-7 pubmed publisher
    ..We conclude that the variants on apolipoprotein C3 and apolipoprotien A5 modulate serum triglyceride levels and increase the risk of coronary artery disease. ..
  5. Perez Martinez P, Corella D, Shen J, Arnett D, Yiannakouris N, Tai E, et al. Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states. Am J Clin Nutr. 2009;89:391-9 pubmed publisher
    Hypertriglyceridemia is a risk factor for cardiovascular disease. Variation in the apolipoprotein A5 (APOA5) and glucokinase regulatory protein (GCKR) genes has been associated with fasting plasma triacylglycerol...
  6. Mattei J, Demissie S, Tucker K, Ordovas J. Apolipoprotein A5 polymorphisms interact with total dietary fat intake in association with markers of metabolic syndrome in Puerto Rican older adults. J Nutr. 2009;139:2301-8 pubmed publisher
    b>APOA5 -1131T > C and S19W single nucleotide polymorphisms (SNP) have been consistently associated with plasma lipid concentration and metabolic syndrome (MetS), alone and in modulation by dietary factors...
  7. Li X, Xu Y, Ding Y, Qin C, Dai Z, Niu L. Polymorphism of apolipoprotein A5 is a risk factor for cerebral infarction in type 2 diabetes. J Huazhong Univ Sci Technolog Med Sci. 2008;28:653-6 pubmed publisher
    This study investigated the association of apolipoprotein A5 (apoA5) gene polymorphism at position -1131T>C with cerebral infarction in patients with type 2 diabetes...
  8. Hsu L, Ko Y, Chang C, Teng M, Wu S, Hu C. Apolipoprotein A5 gene -1131T/C polymorphism is associated with the risk of metabolic syndrome in ethnic Chinese in Taiwan. Clin Chem Lab Med. 2008;46:1714-9 pubmed publisher
    The -1131T>C polymorphism in the apolipoprotein gene A5 (APOA5) was found to be associated with increased levels of plasma triglyceride and decreased levels of high-density lipoprotein cholesterol (HDL-C), which are characteristic ..
  9. Vasilopoulos Y, Sarafidou T, Bagiatis V, Skriapa L, Goutzelas Y, Pervanidou P, et al. Association between polymorphisms in MTHFR and APOA5 and metabolic syndrome in the Greek population. Genet Test Mol Biomarkers. 2011;15:613-7 pubmed publisher
    ..308G>A), methylenetetrahydrofolate reductase (MTHFR) (c.677C>T), APOC3 (c.3175C>G), and APOA5 (g...

More Information

Publications167 found, 100 shown here

  1. Hubacek J, Skodova Z, Adamkova V, Lanska V, Poledne R. The influence of APOAV polymorphisms (T-1131>C and S19>W) on plasma triglyceride levels and risk of myocardial infarction. Clin Genet. 2004;65:126-30 pubmed
    The importance of an APOAV gene for plasma triglyceride level determination has been shown on transgenic and knockout mice...
  2. Elosua R, Ordovas J, Cupples L, Lai C, Demissie S, Fox C, et al. Variants at the APOA5 locus, association with carotid atherosclerosis, and modification by obesity: the Framingham Study. J Lipid Res. 2006;47:990-6 pubmed
    Genetic variation at the apolipoprotein A5 gene (APOA5) is associated with increased triglyceride concentrations, a risk factor for atherosclerosis. Carotid intimal medial thickness (IMT) is a surrogate measure of atherosclerosis burden...
  3. Dallongeville J, Cottel D, Wagner A, Ducimetiere P, Ruidavets J, Arveiler D, et al. The APOA5 Trp19 allele is associated with metabolic syndrome via its association with plasma triglycerides. BMC Med Genet. 2008;9:84 pubmed publisher
    The goal of the present study was to assess the effect of genetic variability at the APOA5/A4/C3/A1 cluster locus on the risk of metabolic syndrome...
  4. Wong K, Ryan R. Characterization of apolipoprotein A-V structure and mode of plasma triacylglycerol regulation. Curr Opin Lipidol. 2007;18:319-24 pubmed
    ..Current and future studies of apoA-V will help to shed light on the molecular basis whereby this protein functions to modulate plasma lipid homeostasis. ..
  5. Havasi V, Szolnoki Z, Talian G, Bene J, Komlosi K, Maasz A, et al. Apolipoprotein A5 gene promoter region T-1131C polymorphism associates with elevated circulating triglyceride levels and confers susceptibility for development of ischemic stroke. J Mol Neurosci. 2006;29:177-83 pubmed
    ..The level of TG was increased in all groups (p < 0.01). The apoA5-1131C allele frequency was approximately twofold in all groups of stroke patients compared with the controls (5 vs ..
  6. Liu Z, Hu M, Baum L, Thomas G, Tomlinson B. Associations of polymorphisms in the apolipoprotein A1/C3/A4/A5 gene cluster with familial combined hyperlipidaemia in Hong Kong Chinese. Atherosclerosis. 2010;208:427-32 pubmed publisher
    ..Thirteen SNPs in the APOA1/C3/A4/A5 cluster were genotyped. Four alleles in APOA5 were associated with FCH (P<0.001)...
  7. Henneman P, Schaap F, Havekes L, Rensen P, Frants R, Van Tol A, et al. Plasma apoAV levels are markedly elevated in severe hypertriglyceridemia and positively correlated with the APOA5 S19W polymorphism. Atherosclerosis. 2007;193:129-34 pubmed
    ..out to determine the association between increased serum TG levels, plasma apoAV levels, and polymorphism of the APOA5 gene, with specific emphasis on the APOA5 S19W variation...
  8. Pennacchio L, Olivier M, Hubacek J, Krauss R, Rubin E, Cohen J. Two independent apolipoprotein A5 haplotypes influence human plasma triglyceride levels. Hum Mol Genet. 2002;11:3031-8 pubmed
    The recently identified apolipoprotein A5 gene (APOA5) has been shown to play an important role in determining plasma triglyceride concentrations in humans and mice...
  9. Choi J, Nam C, Kang D, Eom S, Lee H, Park C, et al. DNA polymorphisms and haplotypes of apolipoprotein A5's attribution to the plasma triglyceride levels in Koreans. Yonsei Med J. 2007;48:609-18 pubmed
    Recent studies using human and mice reported that apolipoprotein A-V (APOA5) gene plays an important role in controlling triglyceride (TG) concentrations...
  10. Lai C, Tai E, Tan C, Cutter J, Chew S, Zhu Y, et al. The APOA5 locus is a strong determinant of plasma triglyceride concentrations across ethnic groups in Singapore. J Lipid Res. 2003;44:2365-73 pubmed
    ..The gene encoding apolipoprotein A-V (APOA5) has been located on chromosome 11, and it is emerging as an important candidate gene for lipoprotein metabolism...
  11. Paula R, Souza V, Benedet A, Souza E, Toledo J, Moraes C, et al. Dietary fat and apolipoprotein genotypes modulate plasma lipoprotein levels in Brazilian elderly women. Mol Cell Biochem. 2010;337:307-15 pubmed publisher
    ..Results are suggestive of a dysbetalipoproteinemic-like phenotype in postmenopausal women, with remarkable gene-diet interaction. ..
  12. Schaap F, Nierman M, Berbee J, Hattori H, Talmud P, Vaessen S, et al. Evidence for a complex relationship between apoA-V and apoC-III in patients with severe hypertriglyceridemia. J Lipid Res. 2006;47:2333-9 pubmed
    ..is underscored by genetic association studies and the identification of truncation-causing mutations in the APOA5 gene as a cause of type V hyperlipidemia, compatible with an LPL-activating role of apoA-V...
  13. Girona J, Guardiola M, Cabre A, Manzanares J, Heras M, Ribalta J, et al. The apolipoprotein A5 gene -1131T-->C polymorphism affects vitamin E plasma concentrations in type 2 diabetic patients. Clin Chem Lab Med. 2008;46:453-7 pubmed publisher
    Variations of the apolipoprotein A5 (APOA5) gene are strongly associated with hypertriglyceridemia. Vitamin E is transported in triglyceride (TG)-rich lipoproteins and therefore could also be modulated by apoAV...
  14. Charriere S, Bernard S, Aqallal M, Merlin M, Billon S, Perrot L, et al. Association of APOA5 -1131T>C and S19W gene polymorphisms with both mild hypertriglyceridemia and hyperchylomicronemia in type 2 diabetic patients. Clin Chim Acta. 2008;394:99-103 pubmed publisher
    Two minor apolipoprotein A5 (APOA5) gene haplotypes, represented by -1131T>C and S19W polymorphisms, are strong determinants of plasma triglyceride (TG) concentration variability across human populations...
  15. Horvatovich K, Bokor S, Baráth A, Maasz A, Kisfali P, Jaromi L, et al. Haplotype analysis of the apolipoprotein A5 gene in obese pediatric patients. Int J Pediatr Obes. 2011;6:e318-25 pubmed publisher
    Apolipoprotein A5 (APOA5) gene variants have been shown to be associated with elevated TG levels; the T-1131C (rs662799) variant has been reported to confer risk for the metabolic syndrome in adult populations...
  16. Hubacek J, Skodova Z, Adamkova V, Lanska V, Pitha J. APOA5 variant Ser19Trp influences a decrease of the total cholesterol in a male 8 year cohort. Clin Biochem. 2006;39:133-6 pubmed
    ..We have evaluated the influence of common apolipoprotein A5 (APOA5) variants (T-1131 > C, Ser19 > Trp and Val153 > Met) on plasma lipid concentrations in 117 males for whom ..
  17. Jang Y, Kim J, Kim O, Lee J, Cho H, Ordovas J, et al. The -1131T-->C polymorphism in the apolipoprotein A5 gene is associated with postprandial hypertriacylglycerolemia; elevated small, dense LDL concentrations; and oxidative stress in nonobese Korean men. Am J Clin Nutr. 2004;80:832-40 pubmed
    ..The objective was to determine associations of the common apolipoprotein A5 gene (APOA5) -1131T-->C polymorphism with postprandial lipemic response and other cardiovascular disease risk factors in ..
  18. Li Y, Wu X, Xu J, Qian Y, Zhou C, Wang B. Apo A5 -1131T/C, FgB -455G/A, -148C/T, and CETP TaqIB gene polymorphisms and coronary artery disease in the Chinese population: a meta-analysis of 15,055 subjects. Mol Biol Rep. 2013;40:1997-2014 pubmed publisher
    ..CETP TaqIB gene polymorphism was suggested to be associated with CAD susceptibility in the Chinese Han population. Carriers with B1 allele of CETP TaqIB gene might be predisposed to CAD in the Chinese Han population. ..
  19. Hamon S, Kardia S, Boerwinkle E, Liu K, Klos K, Clark A, et al. Evidence for consistent intragenic and intergenic interactions between SNP effects in the APOA1/C3/A4/A5 gene cluster. Hum Hered. 2006;61:87-96 pubmed
  20. Jiang Y, Yen C, Chou W, Kuo S, Lee K, Chiu K, et al. Interaction of the G182C polymorphism in the APOA5 gene and fasting plasma glucose on plasma triglycerides in Type 2 diabetic subjects. Diabet Med. 2005;22:1690-5 pubmed
    Apolipoprotein AV (APOA5) is an important determinant of plasma triglyceride concentration...
  21. Horinek A, Vrablik M, Ceska R, Adamkova V, Poledne R, Hubacek J. T-1131-->C polymorphism within the apolipoprotein AV gene in hypertriglyceridemic individuals. Atherosclerosis. 2003;167:369-70 pubmed
  22. Kim J, Kim O, Koh S, Jang Y, Yun S, Ordovas J, et al. Comparison of low-fat meal and high-fat meal on postprandial lipemic response in non-obese men according to the -1131T>C polymorphism of the apolipoprotein A5 (APOA5) gene (randomized cross-over design). J Am Coll Nutr. 2006;25:340-7 pubmed
    ..meal and high-fat (HF) meal on the postprandial lipemic responses according to the -1131T>C polymorphism of the APOA5 gene in a population usually consuming a LF diet and having a high frequency of the variant allele at the APOA5 -..
  23. Hubacek J, Lanska V, Skodova Z, Adamkova V, Poledne R. Sex-specific interaction between APOE and APOA5 variants and determination of plasma lipid levels. Eur J Hum Genet. 2008;16:135-8 pubmed
    The APOA5 and APOE genes play an important role in determination of plasma levels of triglycerides (TG) and total cholesterol (TC)...
  24. Chien K, Chen M, Hsu H, Su T, Chang W, Lee C, et al. Genetic association study of APOA1/C3/A4/A5 gene cluster and haplotypes on triglyceride and HDL cholesterol in a community-based population. Clin Chim Acta. 2008;388:78-83 pubmed
    ..6 polymorphisms, APOA1 -75G>A, APOA1 83C>T, APOC3 3175C>G, APOC3 3206G>T, APOA4 127A>G, and APOA5 553G>T in APOA1/C3/A4/A5 gene and the haplotype structures on triglyceride and HDL traits among ethnic Chinese...
  25. Chen E, Cendoroglo M, Ramos L, Araujo L, Carvalheira G, de Lábio R, et al. APO A-V-1131T-->C polymorphism frequency and its association with morbidity in a Brazilian elderly population. Clin Chem Lab Med. 2006;44:32-6 pubmed
    ..Therefore, the C allele in elderly Brazilian subjects may represent a risk factor for these morbidity interactions, which may lead to better comprehension of their pathophysiology. ..
  26. Endo K, Yanagi H, Araki J, Hirano C, Yamakawa Kobayashi K, Tomura S. Association found between the promoter region polymorphism in the apolipoprotein A-V gene and the serum triglyceride level in Japanese schoolchildren. Hum Genet. 2002;111:570-2 pubmed
    ..of this study was to assess the influence of single nucleotide polymorphism 3 (SNP3) of the apolipoprotein A-V ( APOA5) gene on the serum triglyceride (TG) level in Japanese schoolchildren...
  27. Bertolini S, Pisciotta L, Di Scala L, Langheim S, Bellocchio A, Masturzo P, et al. Genetic polymorphisms affecting the phenotypic expression of familial hypercholesterolemia. Atherosclerosis. 2004;174:57-65 pubmed
    ..These findings show that several common genetic variants influence the lipid phenotype and the CAD risk in FH heterozygotes. ..
  28. Jang Y, Paik J, Hyun Y, Chae J, Kim J, Choi J, et al. The apolipoprotein A5 -1131T>C promoter polymorphism in Koreans: association with plasma APOA5 and serum triglyceride concentrations, LDL particle size and coronary artery disease. Clin Chim Acta. 2009;402:83-7 pubmed publisher
    The association between -1131T>C single nucleotide polymorphism (SNP) of the apolipoprotein A5 gene (APOA5) and hypertriglyceridemia raised the possibility that this SNP could be related to coronary artery disease (CAD) risk...
  29. Qiao Y, Liu R, Tian H, Liu Y, Qiang O, Liu B. [Association of apolipoprotein A5 gene -1131T/C polymorphism with serum lipids and carotid intima-media thickness in patients with type 2 diabetes mellitus]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2008;39:965-8, 999 pubmed
    ..People with homozygote CC have increased risk of type 2 diabetes. But more evidence is needed to prove its association with carotid IMT in patients with type 2 diabetes. ..
  30. Tai E, Ordovas J. Clinical significance of apolipoprotein A5. Curr Opin Lipidol. 2008;19:349-54 pubmed publisher
    ..Several genetic association studies have continued to strengthen the position of APOA5 as a major gene that is involved in triglyceride metabolism and modulated by dietary factors and pharmacological ..
  31. Lind U, Nilsson T, McPheat J, Strömstedt P, Bamberg K, Balendran C, et al. Identification of the human ApoAV gene as a novel RORalpha target gene. Biochem Biophys Res Commun. 2005;330:233-41 pubmed
    ..Adenovirus-mediated overexpression of RORalpha increased the endogenous expression of ApoAV in HepG2 cells and RORalpha also enhanced the activity of an ApoAV promoter construct in transiently transfected ..
  32. Kisfali P, Mohás M, Maasz A, Hadarits F, Markó L, Horvatovich K, et al. Apolipoprotein A5 IVS3+476A allelic variant associates with increased trigliceride levels and confers risk for development of metabolic syndrome in Hungarians. Circ J. 2008;72:40-3 pubmed
    ..Carrying the IVS3+473A allele is associated with elevated triglycerides and confers risk for development of metabolic syndrome, a combination that represents increased risk for development of atherogenic vascular diseases. ..
  33. Suchanek P, Lorenzova A, Poledne R, Hubacek J. Changes of plasma lipids during weight reduction in females depends on APOA5 variants. Ann Nutr Metab. 2008;53:104-8 pubmed publisher
    Apolipoprotein A5 (APOA5) is a determinant of plasma lipids, and its role in body mass index (BMI) determination is discussed...
  34. Sarwar N, Sandhu M, Ricketts S, Butterworth A, Di Angelantonio E, Boekholdt S, et al. Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies. Lancet. 2010;375:1634-9 pubmed publisher
    ..We assessed the -1131T>C (rs662799) promoter polymorphism of the apolipoprotein A5 (APOA5) gene in relation to triglyceride concentration, several other risk factors, and risk of coronary heart disease...
  35. Evans D, Aberle J, Beil F. Resequencing the apolipoprotein A5 (APOA5) gene in patients with various forms of hypertriglyceridemia. Atherosclerosis. 2011;219:715-20 pubmed publisher
    Genomewide association studies (GWAS), conventional association studies and the characterization of families with ApoA5 deficiency have shown that variation in the apolipoprotein A5 (APOA5) gene is associated with plasma triglyceride ..
  36. Pennacchio L, Olivier M, Hubacek J, Cohen J, Cox D, Fruchart J, et al. An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing. Science. 2001;294:169-73 pubmed
    Comparison of genomic DNA sequences from human and mouse revealed a new apolipoprotein (APO) gene (APOAV) located proximal to the well-characterized APOAI/CIII/AIV gene cluster on human 11q23...
  37. Prieur X, Schaap F, Coste H, Rodriguez J. Hepatocyte nuclear factor-4alpha regulates the human apolipoprotein AV gene: identification of a novel response element and involvement in the control by peroxisome proliferator-activated receptor-gamma coactivator-1alpha, AMP-activated protein kinas. Mol Endocrinol. 2005;19:3107-25 pubmed
    The recently discovered apolipoprotein AV (apoAV) gene has been reported to be a key player in modulating plasma triglyceride levels...
  38. Maasz A, Kisfali P, Horvatovich K, Mohás M, Markó L, Csongei V, et al. Apolipoprotein A5 T-1131C variant confers risk for metabolic syndrome. Pathol Oncol Res. 2007;13:243-7 pubmed
    The -1131C is a naturally occurring variant of the apolipoprotein A5 (ApoA5) gene, which has been shown to associate with increased triglyceride levels...
  39. Hyun Y, Jang Y, Chae J, Kim J, Paik J, Kim S, et al. Association of apolipoprotein A5 concentration with serum insulin and triglyceride levels and coronary artery disease in Korean men. Atherosclerosis. 2009;205:568-73 pubmed publisher
    Whereas the relation between apolipoprotein A5 (APOA5) gene polymorphisms and triglycerides (TG) levels is well established, the associations between apoA5 concentrations, TG and coronary artery disease (CAD) remain controversial...
  40. Nowak M, Helleboid Chapman A, Jakel H, Martin G, Duran Sandoval D, Staels B, et al. Insulin-mediated down-regulation of apolipoprotein A5 gene expression through the phosphatidylinositol 3-kinase pathway: role of upstream stimulatory factor. Mol Cell Biol. 2005;25:1537-48 pubmed
    The apolipoprotein A5 gene (APOA5) has been repeatedly implicated in lowering plasma triglyceride levels...
  41. Yamada Y, Kato K, Hibino T, Yokoi K, Matsuo H, Segawa T, et al. Prediction of genetic risk for metabolic syndrome. Atherosclerosis. 2007;191:298-304 pubmed
    ..sex, and the prevalence of smoking revealed that the -1131T-->C polymorphism of the apolipoprotein A-V gene (APOA5) was significantly associated with the prevalence of metabolic syndrome, with the C allele representing a risk ..
  42. Weissglas Volkov D, Aguilar Salinas C, Sinsheimer J, Riba L, Huertas Vazquez A, Ordoñez Sánchez M, et al. Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples. Circ Cardiovasc Genet. 2010;3:31-8 pubmed publisher
    ..These variants were within or near the genes ABCA1, ANGPTL3, APOA5, APOB, CETP, GALNT2, GCKR, LCAT, LIPC, LPL (2), MMAB-MVK, TRIB1, and XKR6-AMAC1L2...
  43. Xu C, Bai R, Zhang D, Li Z, Zhu H, Lai M, et al. Effects of APOA5 -1131T>C (rs662799) on fasting plasma lipids and risk of metabolic syndrome: evidence from a case-control study in China and a meta-analysis. PLoS ONE. 2013;8:e56216 pubmed publisher
    The apolipoprotein A5 (APOA5) gene -1131T>C (rs662799) has been suggested to be involved in the pathway of lipid homeostasis and the development of metabolic syndrome (MetS). However, the findings are not consistent...
  44. Martinelli N, Trabetti E, Bassi A, Girelli D, Friso S, Pizzolo F, et al. The -1131 T>C and S19W APOA5 gene polymorphisms are associated with high levels of triglycerides and apolipoprotein C-III, but not with coronary artery disease: an angiographic study. Atherosclerosis. 2007;191:409-17 pubmed
    ..Two variants of the recently discovered APOA5, 1131 C>T and S19W, have been associated with hypertriglyceridemia, whereas their relation with coronary artery ..
  45. Dorfmeister B, Cooper J, Stephens J, Ireland H, Hurel S, Humphries S, et al. The effect of APOA5 and APOC3 variants on lipid parameters in European Whites, Indian Asians and Afro-Caribbeans with type 2 diabetes. Biochim Biophys Acta. 2007;1772:355-63 pubmed
    Common variants in APOA5 and APOC3 have been associated with differences in plasma triglyceride (TG) levels in healthy individuals...
  46. Maasz A, Kisfali P, Jaromi L, Horvatovich K, Szolnoki Z, Csongei V, et al. Apolipoprotein A5 gene IVS3+G476A allelic variant confers susceptibility for development of ischemic stroke. Circ J. 2008;72:1065-70 pubmed
    T-1131C, T1259C and IVS3+G476A are naturally occurring variants of the apolipoprotein A5 (APOA5) gene and their possible impact on the development of ischemic stroke was investigated in the present study...
  47. Evans D, Buchwald A, Beil F. The single nucleotide polymorphism -1131T>C in the apolipoprotein A5 (APOA5) gene is associated with elevated triglycerides in patients with hyperlipidemia. J Mol Med (Berl). 2003;81:645-54 pubmed
    The -1131T>C polymorphism in the newly identified apolipoprotein A5 (APOA5) gene has been associated with elevated plasma triglycerides. We determined its incidence in 915 patients attending a lipid outpatient clinic...
  48. Gao J, Wei Y, Huang Y, Liu D, Liu G, Wu M, et al. The expression of intact and mutant human apoAI/CIII/AIV/AV gene cluster in transgenic mice. J Biol Chem. 2005;280:12559-66 pubmed
    ..determine the expression of all four apo genes in combination and, most importantly, whether the transcription of apoAV is coregulated by the apoCIII enhancer in the cluster, we generated an intact transgenic line carrying the 116-kb ..
  49. Yuan S, Ma Y, Xie X, Yang Y, Fu Z, Ma X, et al. [Association between apolipoprotein A5 gene polymorphism and coronary heart disease in the Han population from Xinjiang]. Zhonghua Liu Xing Bing Xue Za Zhi. 2011;32:51-4 pubmed
    ..553G>T polymorphism of apolipoprotein A5 (ApoA5) gene and the influence of serum lipid level in the Han ethnic population of Xinjiang...
  50. Martin S, Nicaud V, Humphries S, Talmud P. Contribution of APOA5 gene variants to plasma triglyceride determination and to the response to both fat and glucose tolerance challenges. Biochim Biophys Acta. 2003;1637:217-25 pubmed
    The aim of this study was to investigate the influence of APOA5 variants on fasting lipids and to the response to both an oral fat tolerance test (OFTT) and an oral glucose tolerance test (OGTT)...
  51. Tang Y, Sun P, Guo D, Ferro A, Ji Y, Chen Q, et al. A genetic variant c.553G > T in the apolipoprotein A5 gene is associated with an increased risk of coronary artery disease and altered triglyceride levels in a Chinese population. Atherosclerosis. 2006;185:433-7 pubmed
    ..Recently, a new apolipoprotein playing an important role in TG metabolism named apolipoprotein AV (apoAV) was discovered, which is encoded by the APOA5 gene...
  52. Yuan S, Ma Y, Xie X, Yang Y, Fu Z, Ma X, et al. [Association of apolipoprotein A5 gene polymorphism with coronary heart disease in Uygur population of Xinjiang]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2011;28:73-7 pubmed publisher
    To investigate the association of the -12238T/C polymorphism of apolipoprotein A5 (APOA5) gene with coronary heart disease (CHD) and the influence of serum lipid levels in Chinese Uygur population of Xinjiang...
  53. Corella D, Lai C, Demissie S, Cupples L, Manning A, Tucker K, et al. APOA5 gene variation modulates the effects of dietary fat intake on body mass index and obesity risk in the Framingham Heart Study. J Mol Med (Berl). 2007;85:119-28 pubmed
    ..Our objective was to study whether dietary intake modulates the association between APOA5 gene variation and body weight in a large population-based study...
  54. Kao J, Wen H, Chien K, Hsu H, Lin S. A novel genetic variant in the apolipoprotein A5 gene is associated with hypertriglyceridemia. Hum Mol Genet. 2003;12:2533-9 pubmed
    The apolipoprotein A5 gene (APOA5 ) has been shown to play an important role in determining plasma triglyceride concentrations in humans. We describe here a novel variant, c...
  55. Klos K, Hamon S, Clark A, Boerwinkle E, Liu K, Sing C. APOA5 polymorphisms influence plasma triglycerides in young, healthy African Americans and whites of the CARDIA Study. J Lipid Res. 2005;46:564-71 pubmed
    Genetic variation in the apolipoprotein A-V gene (APOA5) has been associated with variation in plasma triglyceride (TG) levels in African American and white females and males older than 40 years and/or at increased risk of coronary ..
  56. Ruiz Narvaez E, Yang Y, Nakanishi Y, Kirchdorfer J, Campos H. APOC3/A5 haplotypes, lipid levels, and risk of myocardial infarction in the Central Valley of Costa Rica. J Lipid Res. 2005;46:2605-13 pubmed
    Genetic variation in the APOC3 and APOA5 genes has been associated with plasma triglyceride concentrations and may affect the risk of myocardial infarction (MI)...
  57. Jiang C, Liu B, Cheung B, Lam T, Lin J, Li Jin Y, et al. A single nucleotide polymorphism in APOA5 determines triglyceride levels in Hong Kong and Guangzhou Chinese. Eur J Hum Genet. 2010;18:1255-60 pubmed publisher
    Single nucleotide polymorphisms (SNPs) in the apolipoprotein A5 (APOA5) gene have been associated with hypertriglyceridaemia...
  58. Cardona F, Guardiola M, Queipo Ortuño M, Murri M, Ribalta J, Tinahones F. The -1131T>C SNP of the APOA5 gene modulates response to fenofibrate treatment in patients with the metabolic syndrome: a postprandial study. Atherosclerosis. 2009;206:148-52 pubmed publisher
    ..We hypothesised that variability in the promoter of the APOA5 gene may affect the individual response to fibrate therapy, in both the fasting and postprandial states...
  59. Fruchart Najib J, Bauge E, Niculescu L, Pham T, Thomas B, Rommens C, et al. Mechanism of triglyceride lowering in mice expressing human apolipoprotein A5. Biochem Biophys Res Commun. 2004;319:397-404 pubmed
    Overexpression of human APOA5 in mice results in dramatically decreased plasma triglyceride levels. In this study we explored the mechanism underlying this hypotriglyceridemic effect...
  60. Wu C, Chang Y, Hua S, Wu H, Lee W, Chiang F, et al. A triglyceride-raising APOA5 genetic variant is negatively associated with obesity and BMI in the Chinese population. Obesity (Silver Spring). 2010;18:1964-8 pubmed publisher
    ..Genetic variants in the APOA5 gene were strongly associated with plasma TG concentrations...
  61. Surendran R, Visser M, Heemelaar S, Wang J, Peter J, Defesche J, et al. Mutations in LPL, APOC2, APOA5, GPIHBP1 and LMF1 in patients with severe hypertriglyceridaemia. J Intern Med. 2012;272:185-96 pubmed publisher
    ..The coding regions of LPL, APOC2, APOA5 and two novel genes, lipase maturation factor 1 (LMF1) and GPI-anchored high-density lipoprotein (HDL)-binding ..
  62. Wang J, Ban M, Zou G, Cao H, Lin T, Kennedy B, et al. Polygenic determinants of severe hypertriglyceridemia. Hum Mol Genet. 2008;17:2894-9 pubmed publisher
    ..genotypes for: GALNT2 rs4846914, TBL2/MLXIPL rs17145738, TRIB1 rs17321515, ANGPTL3 rs12130333, GCKR rs780094, APOA5 rs3135506 (S19W), APOA5 rs662799 (-1131T > C), APOE (isoforms) and LPL rs328 (S447X)...
  63. Ramakrishnan L, Sachdev H, Sharma M, Abraham R, Prakash S, Gupta D, et al. Relationship of APOA5, PPAR? and HL gene variants with serial changes in childhood body mass index and coronary artery disease risk factors in young adulthood. Lipids Health Dis. 2011;10:68 pubmed publisher
    ..We analysed polymorphisms in APOA5, hepatic lipase and PPAR? genes and investigated their association with birth weight and serial changes in BMI...
  64. Ward K, Shields B, Knight B, Salzmann M, Hattersley A, Frayling T. Genetic variants in Apolipoprotein AV alter triglyceride concentrations in pregnancy. Lipids Health Dis. 2003;2:9 pubmed
    ..those in the Apolipoprotein E (ApoE), Lipoprotein Lipase (LPL), and most recently, the Apolipoprotein AV (ApoAV) gene...
  65. Sundl I, Guardiola M, Khoschsorur G, Solà R, Vallvé J, Godas G, et al. Increased concentrations of circulating vitamin E in carriers of the apolipoprotein A5 gene - 1131T>C variant and associations with plasma lipids and lipid peroxidation. J Lipid Res. 2007;48:2506-13 pubmed
    The aim of this study was to investigate the effects of the apolipoprotein A5 (APOA5) 1131T>C gene variant on vitamin E status and lipid profile...
  66. Dorfmeister B, Zeng W, Dichlberger A, Nilsson S, Schaap F, Hubacek J, et al. Effects of six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding. Arterioscler Thromb Vasc Biol. 2008;28:1866-71 pubmed publisher
    ..We studied the impact in vitro on LPL activity and receptor binding of 3 novel heterozygous variants, apoAV-E255G, -G271C, and -H321L, together with the previously reported -G185C, -Q139X, -Q148X, and a novel construct -..
  67. Chen E, Furuya T, Mazzotti D, Ota V, Cendoroglo M, Ramos L, et al. APOA1/A5 variants and haplotypes as a risk factor for obesity and better lipid profiles in a Brazilian Elderly Cohort. Lipids. 2010;45:511-7 pubmed publisher
    ..We aimed to investigate the associations of rs12721026 (APOA1) and rs1729408 (APOA5) polymorphisms and their haplotypes with some age-related diseases, as well as with lipids and proteins serum ..
  68. Tan A, Sun J, Xia N, Qin X, Hu Y, Zhang S, et al. A genome-wide association and gene-environment interaction study for serum triglycerides levels in a healthy Chinese male population. Hum Mol Genet. 2012;21:1658-64 pubmed publisher
    ..Two previously reported SNPs (rs651821 in APOA5, rs328 in LPL) were replicated in the second stage, and the combined P-values were 9.19 × 10(-26) and 1...
  69. Vrablik M, Horinek A, Ceska R, Adamkova V, Poledne R, Hubacek J. Ser19-->Trp polymorphism within the apolipoprotein AV gene in hypertriglyceridaemic people. J Med Genet. 2003;40:e105 pubmed
  70. Li G, Wang J, Yan S, Chen B, Xue H, Wu G. Genetic effect of two polymorphisms in the apolipoprotein A5 gene and apolipoprotein C3 gene on serum lipids and lipoproteins levels in a Chinese population. Clin Genet. 2004;65:470-6 pubmed
    Two polymorphisms, apolipoprotein A5 (APOA5) -1131T>C and apolipoprotein C3 (APOC3) -482C>T, were examined in a healthy Chinese group...
  71. Song K. Orphan nuclear receptor Nur77 participates in human apolipoprotein A5 gene expression. Biochem Biophys Res Commun. 2010;392:63-6 pubmed publisher
    ..Here, we reported the identification of human apolipoprotein A5 (ApoA5), which implicated in lowering plasma triglyceride levels, as a novel target gene of Nur77...
  72. Li X, Su D, Zhang X, Zhang C. Association of apolipoprotein A5 gene promoter region -1131T>C with risk of stroke in Han Chinese. Eur J Intern Med. 2011;22:99-102 pubmed publisher
    ..Recently, the -1131T>C polymorphism in apolipoprotein A5 (APOA5) gene has been reported to be associated with ischemic stroke in different racial groups, but no data is available ..
  73. Pennacchio L, Rubin E. Apolipoprotein A5, a newly identified gene that affects plasma triglyceride levels in humans and mice. Arterioscler Thromb Vasc Biol. 2003;23:529-34 pubmed
    Apolipoprotein A5 (APOA5) is a newly described member of the apolipoprotein gene family whose initial discovery arose from comparative sequence analysis of the mammalian APOA1/C3/A4 gene cluster...
  74. Szalai C, Keszei M, Duba J, Prohaszka Z, Kozma G, Csaszar A, et al. Polymorphism in the promoter region of the apolipoprotein A5 gene is associated with an increased susceptibility for coronary artery disease. Atherosclerosis. 2004;173:109-14 pubmed
    ..Recently, a T/C polymorphism in the promoter region of the apoA5 gene at position 1131 has been found that is associated with an increased plasma TG concentration...
  75. Liu H, Zhang S, Lin J, Li H, Huang A, Xiao C, et al. Association between DNA variant sites in the apolipoprotein A5 gene and coronary heart disease in Chinese. Metabolism. 2005;54:568-72 pubmed
    The recently discovered apolipoprotein A5 ( APOA5 ) gene has been shown to be important in determining plasma triglyceride levels, a major cardiovascular disease risk factor...
  76. Wang J, Cao H, Ban M, Kennedy B, Zhu S, Anand S, et al. Resequencing genomic DNA of patients with severe hypertriglyceridemia (MIM 144650). Arterioscler Thromb Vasc Biol. 2007;27:2450-5 pubmed
    ..We therefore resequenced 3 candidate genes, namely LPL, APOC2, and APOA5, to search for accumulation of missense mutations in patients with severe HTG compared with normolipidemic ..
  77. Hubacek J, Wang W, Skodova Z, Adamkova V, Vrablik M, Horinek A, et al. APOA5 Ala315>Val, identified in patients with severe hypertriglyceridemia, is a common mutation with no major effects on plasma lipid levels. Clin Chem Lab Med. 2008;46:773-7 pubmed publisher
    The importance of the apolipoprotein A5 (APOA5) gene in determining plasma triglyceride (TG) levels has been demonstrated in transgenic and knockout mice and confirmed by human association studies in different ethnic groups...
  78. Lin J, Fang D, Du J, Shigdar S, Xiao L, Zhou X, et al. Elevated levels of triglyceride and triglyceride-rich lipoprotein triglyceride induced by a high-carbohydrate diet is associated with polymorphisms of APOA5-1131T>C and APOC3-482C>T in Chinese healthy young adults. Ann Nutr Metab. 2011;58:150-7 pubmed publisher
    ..Therefore, 2 polymorphisms, i.e. APOA5-1131T>C and APOC3-482C>T, and serum lipids were examined in a Chinese healthy young population with high-..
  79. Jakel H, Nowak M, Moitrot E, Dehondt H, Hum D, Pennacchio L, et al. The liver X receptor ligand T0901317 down-regulates APOA5 gene expression through activation of SREBP-1c. J Biol Chem. 2004;279:45462-9 pubmed
    ..In this study, we investigated the contribution of APOA5 to the liver X receptor (LXR) ligand-mediated effect on plasma triglyceride levels...
  80. Dallongeville J, Cottel D, Montaye M, Codron V, Amouyel P, Helbecque N. Impact of APOA5/A4/C3 genetic polymorphisms on lipid variables and cardiovascular disease risk in French men. Int J Cardiol. 2006;106:152-6 pubmed
    The goal of the present study was to assess the impact of 4 single nucleotide polymorphisms (SNPs) of APOA5/A4/C3 gene cluster on lipid levels and coronary heart disease (CHD) risk in French men...
  81. Shanker J, Perumal G, Rao V, Khadrinarasimhiah N, John S, Hebbagodi S, et al. Genetic studies on the APOA1-C3-A5 gene cluster in Asian Indians with premature coronary artery disease. Lipids Health Dis. 2008;7:33 pubmed publisher
    ..namely the -75G>A, +83C>T SNPs in the APOA1 gene, the Sac1 SNP in the APOC3 gene and the S19W variant in the APOA5 gene to plasma lipids and CAD in 190 affected sibling pairs (ASPs) belonging to Asian Indian families with a ..
  82. Kisfali P, Mohas M, Maasz A, Polgar N, Hadarits F, Marko L, et al. Haplotype analysis of the apolipoprotein A5 gene in patients with the metabolic syndrome. Nutr Metab Cardiovasc Dis. 2010;20:505-11 pubmed publisher
    In recent studies, the T-1131C variant of apolipoprotein A5 (APOA5) gene was found to confer a risk for metabolic syndrome (MS)...
  83. Johansen C, Wang J, Lanktree M, Cao H, McIntyre A, Ban M, et al. Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia. Nat Genet. 2010;42:684-7 pubmed publisher
    ..Through GWAS, we identified common variants in APOA5, GCKR, LPL and APOB associated with HTG...
  84. Hodoglugil U, Tanyolac S, Williamson D, Huang Y, Mahley R. Apolipoprotein A-V: a potential modulator of plasma triglyceride levels in Turks. J Lipid Res. 2006;47:144-53 pubmed
    The apolipoprotein A-V gene (APOA5) plays an important role in determining plasma triglyceride levels...
  85. Talmud P, Martin S, Taskinen M, Frick M, Nieminen M, Kesaniemi Y, et al. APOA5 gene variants, lipoprotein particle distribution, and progression of coronary heart disease: results from the LOCAT study. J Lipid Res. 2004;45:750-6 pubmed
    ..We examined the relationship of APOA5 -1131T>C and S19W with lipid subfractions and progression of atherosclerosis in the Lopid Coronary Angiography ..
  86. Chan D, Watts G, Nguyen M, Barrett P. Apolipoproteins C-III and A-V as predictors of very-low-density lipoprotein triglyceride and apolipoprotein B-100 kinetics. Arterioscler Thromb Vasc Biol. 2006;26:590-6 pubmed
    ..We also demonstrated that the kinetics of VLDL triglycerides and apoB are closely coupled. Our data do not support a role for plasma apoA-V in regulating VLDL kinetics. ..
  87. Maasz A, Kisfali P, Szolnoki Z, Hadarits F, Melegh B. Apolipoprotein A5 gene C56G variant confers risk for the development of large-vessel associated ischemic stroke. J Neurol. 2008;255:649-54 pubmed publisher
    ..aim of our study was to investigate the possible association between the C56G variant of the apolipoprotein A5 (APOA5) gene and ischemic stroke...
  88. Caussy C, Charriere S, Marcais C, Di Filippo M, Sassolas A, Delay M, et al. An APOA5 3' UTR variant associated with plasma triglycerides triggers APOA5 downregulation by creating a functional miR-485-5p binding site. Am J Hum Genet. 2014;94:129-34 pubmed publisher
    b>APOA5 c.*158C>T (rs2266788), located in the 3' UTR, belongs to APOA5 haplotype 2 (APOA5*2), which is strongly associated with plasma triglyceride levels and modulates the occurrence of both moderate and severe hypertriglyceridemia...
  89. Vu Dac N, Gervois P, Jakel H, Nowak M, Bauge E, Dehondt H, et al. Apolipoprotein A5, a crucial determinant of plasma triglyceride levels, is highly responsive to peroxisome proliferator-activated receptor alpha activators. J Biol Chem. 2003;278:17982-5 pubmed
    ..b>apoAV represents the first described apolipoprotein where overexpression lowers triglyceride levels...
  90. Lee K, Ayyobi A, Frohlich J, Hill J. APOA5 gene polymorphism modulates levels of triglyceride, HDL cholesterol and FERHDL but is not a risk factor for coronary artery disease. Atherosclerosis. 2004;176:165-72 pubmed
    Variation in the APOA5 gene has been shown to be associated with triglyceride levels in several independent population studies...