APOA5

Summary

Gene Symbol: APOA5
Description: apolipoprotein A5
Alias: APOAV, RAP3, apolipoprotein A-V, apo-AV, apolipoprotein A-V precursor variant 3, regeneration-associated protein 3
Species: human
Products:     APOA5

Top Publications

  1. Fruchart Najib J, Bauge E, Niculescu L, Pham T, Thomas B, Rommens C, et al. Mechanism of triglyceride lowering in mice expressing human apolipoprotein A5. Biochem Biophys Res Commun. 2004;319:397-404 pubmed
    Overexpression of human APOA5 in mice results in dramatically decreased plasma triglyceride levels. In this study we explored the mechanism underlying this hypotriglyceridemic effect...
  2. Surendran R, Visser M, Heemelaar S, Wang J, Peter J, Defesche J, et al. Mutations in LPL, APOC2, APOA5, GPIHBP1 and LMF1 in patients with severe hypertriglyceridaemia. J Intern Med. 2012;272:185-96 pubmed publisher
    ..The coding regions of LPL, APOC2, APOA5 and two novel genes, lipase maturation factor 1 (LMF1) and GPI-anchored high-density lipoprotein (HDL)-binding ..
  3. Ramakrishnan L, Sachdev H, Sharma M, Abraham R, Prakash S, Gupta D, et al. Relationship of APOA5, PPAR? and HL gene variants with serial changes in childhood body mass index and coronary artery disease risk factors in young adulthood. Lipids Health Dis. 2011;10:68 pubmed publisher
    ..We analysed polymorphisms in APOA5, hepatic lipase and PPAR? genes and investigated their association with birth weight and serial changes in BMI...
  4. Wang J, Ban M, Zou G, Cao H, Lin T, Kennedy B, et al. Polygenic determinants of severe hypertriglyceridemia. Hum Mol Genet. 2008;17:2894-9 pubmed publisher
    ..genotypes for: GALNT2 rs4846914, TBL2/MLXIPL rs17145738, TRIB1 rs17321515, ANGPTL3 rs12130333, GCKR rs780094, APOA5 rs3135506 (S19W), APOA5 rs662799 (-1131T > C), APOE (isoforms) and LPL rs328 (S447X)...
  5. Dorfmeister B, Zeng W, Dichlberger A, Nilsson S, Schaap F, Hubacek J, et al. Effects of six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding. Arterioscler Thromb Vasc Biol. 2008;28:1866-71 pubmed publisher
    ..We studied the impact in vitro on LPL activity and receptor binding of 3 novel heterozygous variants, apoAV-E255G, -G271C, and -H321L, together with the previously reported -G185C, -Q139X, -Q148X, and a novel construct -..
  6. Chen E, Furuya T, Mazzotti D, Ota V, Cendoroglo M, Ramos L, et al. APOA1/A5 variants and haplotypes as a risk factor for obesity and better lipid profiles in a Brazilian Elderly Cohort. Lipids. 2010;45:511-7 pubmed publisher
    ..We aimed to investigate the associations of rs12721026 (APOA1) and rs1729408 (APOA5) polymorphisms and their haplotypes with some age-related diseases, as well as with lipids and proteins serum ..
  7. Tan A, Sun J, Xia N, Qin X, Hu Y, Zhang S, et al. A genome-wide association and gene-environment interaction study for serum triglycerides levels in a healthy Chinese male population. Hum Mol Genet. 2012;21:1658-64 pubmed publisher
    ..Two previously reported SNPs (rs651821 in APOA5, rs328 in LPL) were replicated in the second stage, and the combined P-values were 9.19 × 10(-26) and 1...
  8. Li G, Wang J, Yan S, Chen B, Xue H, Wu G. Genetic effect of two polymorphisms in the apolipoprotein A5 gene and apolipoprotein C3 gene on serum lipids and lipoproteins levels in a Chinese population. Clin Genet. 2004;65:470-6 pubmed
    Two polymorphisms, apolipoprotein A5 (APOA5) -1131T>C and apolipoprotein C3 (APOC3) -482C>T, were examined in a healthy Chinese group...
  9. Song K. Orphan nuclear receptor Nur77 participates in human apolipoprotein A5 gene expression. Biochem Biophys Res Commun. 2010;392:63-6 pubmed publisher
    ..Here, we reported the identification of human apolipoprotein A5 (ApoA5), which implicated in lowering plasma triglyceride levels, as a novel target gene of Nur77...
  10. Szalai C, Keszei M, Duba J, Prohaszka Z, Kozma G, Csaszar A, et al. Polymorphism in the promoter region of the apolipoprotein A5 gene is associated with an increased susceptibility for coronary artery disease. Atherosclerosis. 2004;173:109-14 pubmed
    ..Recently, a T/C polymorphism in the promoter region of the apoA5 gene at position 1131 has been found that is associated with an increased plasma TG concentration...

Detail Information

Publications100

  1. Fruchart Najib J, Bauge E, Niculescu L, Pham T, Thomas B, Rommens C, et al. Mechanism of triglyceride lowering in mice expressing human apolipoprotein A5. Biochem Biophys Res Commun. 2004;319:397-404 pubmed
    Overexpression of human APOA5 in mice results in dramatically decreased plasma triglyceride levels. In this study we explored the mechanism underlying this hypotriglyceridemic effect...
  2. Surendran R, Visser M, Heemelaar S, Wang J, Peter J, Defesche J, et al. Mutations in LPL, APOC2, APOA5, GPIHBP1 and LMF1 in patients with severe hypertriglyceridaemia. J Intern Med. 2012;272:185-96 pubmed publisher
    ..The coding regions of LPL, APOC2, APOA5 and two novel genes, lipase maturation factor 1 (LMF1) and GPI-anchored high-density lipoprotein (HDL)-binding ..
  3. Ramakrishnan L, Sachdev H, Sharma M, Abraham R, Prakash S, Gupta D, et al. Relationship of APOA5, PPAR? and HL gene variants with serial changes in childhood body mass index and coronary artery disease risk factors in young adulthood. Lipids Health Dis. 2011;10:68 pubmed publisher
    ..We analysed polymorphisms in APOA5, hepatic lipase and PPAR? genes and investigated their association with birth weight and serial changes in BMI...
  4. Wang J, Ban M, Zou G, Cao H, Lin T, Kennedy B, et al. Polygenic determinants of severe hypertriglyceridemia. Hum Mol Genet. 2008;17:2894-9 pubmed publisher
    ..genotypes for: GALNT2 rs4846914, TBL2/MLXIPL rs17145738, TRIB1 rs17321515, ANGPTL3 rs12130333, GCKR rs780094, APOA5 rs3135506 (S19W), APOA5 rs662799 (-1131T > C), APOE (isoforms) and LPL rs328 (S447X)...
  5. Dorfmeister B, Zeng W, Dichlberger A, Nilsson S, Schaap F, Hubacek J, et al. Effects of six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding. Arterioscler Thromb Vasc Biol. 2008;28:1866-71 pubmed publisher
    ..We studied the impact in vitro on LPL activity and receptor binding of 3 novel heterozygous variants, apoAV-E255G, -G271C, and -H321L, together with the previously reported -G185C, -Q139X, -Q148X, and a novel construct -..
  6. Chen E, Furuya T, Mazzotti D, Ota V, Cendoroglo M, Ramos L, et al. APOA1/A5 variants and haplotypes as a risk factor for obesity and better lipid profiles in a Brazilian Elderly Cohort. Lipids. 2010;45:511-7 pubmed publisher
    ..We aimed to investigate the associations of rs12721026 (APOA1) and rs1729408 (APOA5) polymorphisms and their haplotypes with some age-related diseases, as well as with lipids and proteins serum ..
  7. Tan A, Sun J, Xia N, Qin X, Hu Y, Zhang S, et al. A genome-wide association and gene-environment interaction study for serum triglycerides levels in a healthy Chinese male population. Hum Mol Genet. 2012;21:1658-64 pubmed publisher
    ..Two previously reported SNPs (rs651821 in APOA5, rs328 in LPL) were replicated in the second stage, and the combined P-values were 9.19 × 10(-26) and 1...
  8. Li G, Wang J, Yan S, Chen B, Xue H, Wu G. Genetic effect of two polymorphisms in the apolipoprotein A5 gene and apolipoprotein C3 gene on serum lipids and lipoproteins levels in a Chinese population. Clin Genet. 2004;65:470-6 pubmed
    Two polymorphisms, apolipoprotein A5 (APOA5) -1131T>C and apolipoprotein C3 (APOC3) -482C>T, were examined in a healthy Chinese group...
  9. Song K. Orphan nuclear receptor Nur77 participates in human apolipoprotein A5 gene expression. Biochem Biophys Res Commun. 2010;392:63-6 pubmed publisher
    ..Here, we reported the identification of human apolipoprotein A5 (ApoA5), which implicated in lowering plasma triglyceride levels, as a novel target gene of Nur77...
  10. Szalai C, Keszei M, Duba J, Prohaszka Z, Kozma G, Csaszar A, et al. Polymorphism in the promoter region of the apolipoprotein A5 gene is associated with an increased susceptibility for coronary artery disease. Atherosclerosis. 2004;173:109-14 pubmed
    ..Recently, a T/C polymorphism in the promoter region of the apoA5 gene at position 1131 has been found that is associated with an increased plasma TG concentration...
  11. Lin J, Fang D, Du J, Shigdar S, Xiao L, Zhou X, et al. Elevated levels of triglyceride and triglyceride-rich lipoprotein triglyceride induced by a high-carbohydrate diet is associated with polymorphisms of APOA5-1131T>C and APOC3-482C>T in Chinese healthy young adults. Ann Nutr Metab. 2011;58:150-7 pubmed publisher
    ..Therefore, 2 polymorphisms, i.e. APOA5-1131T>C and APOC3-482C>T, and serum lipids were examined in a Chinese healthy young population with high-..
  12. Wang J, Cao H, Ban M, Kennedy B, Zhu S, Anand S, et al. Resequencing genomic DNA of patients with severe hypertriglyceridemia (MIM 144650). Arterioscler Thromb Vasc Biol. 2007;27:2450-5 pubmed
    ..We therefore resequenced 3 candidate genes, namely LPL, APOC2, and APOA5, to search for accumulation of missense mutations in patients with severe HTG compared with normolipidemic ..
  13. Hubacek J, Wang W, Skodova Z, Adamkova V, Vrablik M, Horinek A, et al. APOA5 Ala315>Val, identified in patients with severe hypertriglyceridemia, is a common mutation with no major effects on plasma lipid levels. Clin Chem Lab Med. 2008;46:773-7 pubmed publisher
    The importance of the apolipoprotein A5 (APOA5) gene in determining plasma triglyceride (TG) levels has been demonstrated in transgenic and knockout mice and confirmed by human association studies in different ethnic groups...
  14. Pennacchio L, Rubin E. Apolipoprotein A5, a newly identified gene that affects plasma triglyceride levels in humans and mice. Arterioscler Thromb Vasc Biol. 2003;23:529-34 pubmed
    Apolipoprotein A5 (APOA5) is a newly described member of the apolipoprotein gene family whose initial discovery arose from comparative sequence analysis of the mammalian APOA1/C3/A4 gene cluster...
  15. Kisfali P, Mohas M, Maasz A, Polgar N, Hadarits F, Marko L, et al. Haplotype analysis of the apolipoprotein A5 gene in patients with the metabolic syndrome. Nutr Metab Cardiovasc Dis. 2010;20:505-11 pubmed publisher
    In recent studies, the T-1131C variant of apolipoprotein A5 (APOA5) gene was found to confer a risk for metabolic syndrome (MS)...
  16. Jakel H, Nowak M, Moitrot E, Dehondt H, Hum D, Pennacchio L, et al. The liver X receptor ligand T0901317 down-regulates APOA5 gene expression through activation of SREBP-1c. J Biol Chem. 2004;279:45462-9 pubmed
    ..In this study, we investigated the contribution of APOA5 to the liver X receptor (LXR) ligand-mediated effect on plasma triglyceride levels...
  17. Johansen C, Wang J, Lanktree M, Cao H, McIntyre A, Ban M, et al. Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia. Nat Genet. 2010;42:684-7 pubmed publisher
    ..Through GWAS, we identified common variants in APOA5, GCKR, LPL and APOB associated with HTG...
  18. Shanker J, Perumal G, Rao V, Khadrinarasimhiah N, John S, Hebbagodi S, et al. Genetic studies on the APOA1-C3-A5 gene cluster in Asian Indians with premature coronary artery disease. Lipids Health Dis. 2008;7:33 pubmed publisher
    ..namely the -75G>A, +83C>T SNPs in the APOA1 gene, the Sac1 SNP in the APOC3 gene and the S19W variant in the APOA5 gene to plasma lipids and CAD in 190 affected sibling pairs (ASPs) belonging to Asian Indian families with a ..
  19. Dallongeville J, Cottel D, Montaye M, Codron V, Amouyel P, Helbecque N. Impact of APOA5/A4/C3 genetic polymorphisms on lipid variables and cardiovascular disease risk in French men. Int J Cardiol. 2006;106:152-6 pubmed
    The goal of the present study was to assess the impact of 4 single nucleotide polymorphisms (SNPs) of APOA5/A4/C3 gene cluster on lipid levels and coronary heart disease (CHD) risk in French men...
  20. Maasz A, Kisfali P, Szolnoki Z, Hadarits F, Melegh B. Apolipoprotein A5 gene C56G variant confers risk for the development of large-vessel associated ischemic stroke. J Neurol. 2008;255:649-54 pubmed publisher
    ..aim of our study was to investigate the possible association between the C56G variant of the apolipoprotein A5 (APOA5) gene and ischemic stroke...
  21. Chan D, Watts G, Nguyen M, Barrett P. Apolipoproteins C-III and A-V as predictors of very-low-density lipoprotein triglyceride and apolipoprotein B-100 kinetics. Arterioscler Thromb Vasc Biol. 2006;26:590-6 pubmed
    ..We also demonstrated that the kinetics of VLDL triglycerides and apoB are closely coupled. Our data do not support a role for plasma apoA-V in regulating VLDL kinetics. ..
  22. Talmud P, Martin S, Taskinen M, Frick M, Nieminen M, Kesaniemi Y, et al. APOA5 gene variants, lipoprotein particle distribution, and progression of coronary heart disease: results from the LOCAT study. J Lipid Res. 2004;45:750-6 pubmed
    ..We examined the relationship of APOA5 -1131T>C and S19W with lipid subfractions and progression of atherosclerosis in the Lopid Coronary Angiography ..
  23. Delgado Lista J, Perez Jimenez F, Ruano J, Perez Martinez P, Fuentes F, Criado Garcia J, et al. Effects of variations in the APOA1/C3/A4/A5 gene cluster on different parameters of postprandial lipid metabolism in healthy young men. J Lipid Res. 2010;51:63-73 pubmed publisher
    ..APOC3 -640 was associated with altered TG kinetics but not its magnitude. We have identified new associations between SNPs in the APOA1/C3/A4/A5 gene cluster and altered postprandial lipid metabolism. ..
  24. Pollin T, Damcott C, Shen H, Ott S, Shelton J, Horenstein R, et al. A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection. Science. 2008;322:1702-5 pubmed publisher
    ..Subclinical atherosclerosis, as measured by coronary artery calcification, was less common in carriers than noncarriers, which suggests that lifelong deficiency of apoC-III has a cardioprotective effect. ..
  25. Lee K, Ayyobi A, Frohlich J, Hill J. APOA5 gene polymorphism modulates levels of triglyceride, HDL cholesterol and FERHDL but is not a risk factor for coronary artery disease. Atherosclerosis. 2004;176:165-72 pubmed
    Variation in the APOA5 gene has been shown to be associated with triglyceride levels in several independent population studies...
  26. Aouizerat B, Kulkarni M, Heilbron D, Drown D, Raskin S, Pullinger C, et al. Genetic analysis of a polymorphism in the human apoA-V gene: effect on plasma lipids. J Lipid Res. 2003;44:1167-73 pubmed
    Recent discovery and characterization of APOAV suggests a role in metabolism of triglyceride (TG)-rich lipoproteins. Previously, variation at the APOAV locus was shown to modestly influence plasma TGs in normolipidemic samples...
  27. Baroukh N, Bauge E, Akiyama J, Chang J, Afzal V, Fruchart J, et al. Analysis of apolipoprotein A5, c3, and plasma triglyceride concentrations in genetically engineered mice. Arterioscler Thromb Vasc Biol. 2004;24:1297-302 pubmed
    ..Furthermore, we find that human ApoAV plasma protein levels in the "double transgenic" mice are approximately 500-fold lower than human ..
  28. Qi L, Liu S, Rifai N, Hunter D, Hu F. Associations of the apolipoprotein A1/C3/A4/A5 gene cluster with triglyceride and HDL cholesterol levels in women with type 2 diabetes. Atherosclerosis. 2007;192:204-10 pubmed
    ..A linkage disequilibrium (LD) breakdown was observed between APOA5 and other genes. APOA5 S19W was associated with significantly higher fasting TG levels (P=0.001)...
  29. Liu H, Wang C, Zhang S, Xiao C, Li X, Zhang K, et al. [Association of APOA5 gene single nucleotide polymorphism with levels of lipids and coronary heart disease in Chinese]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2004;21:335-8 pubmed
    To investigate the single nucleotide polymorphism 4 (SNP4) of the apolipoprotein A5 (APOA5) gene possible association with coronary heart disease(CHD) and its distribution of in Chinese Han population...
  30. Sousa M, Alia P, Pintó X, Corbella E, Navarro M. Interaction between APOA5 -1131T>C and APOE polymorphisms and their association with severe hypertriglyceridemia. Clin Chim Acta. 2008;395:68-71 pubmed publisher
    Apolipoprotein A5 gene (APOA5) has been shown to modulate plasma triglyceride concentrations...
  31. Li Y, Yin R, Lai C, Li M, Long X, Li K, et al. Association of apolipoprotein A5 gene polymorphisms and serum lipid levels. Nutr Metab Cardiovasc Dis. 2011;21:947-56 pubmed publisher
    ..The present study was undertaken to detect the APOA5 gene polymorphisms and their associations with lipid profiles in the Guangxi Hei Yi Zhuang and Han populations...
  32. Chien K, Fang W, Wen H, Lin H, Lin Y, Lin S, et al. APOA1/C3/A5 haplotype and risk of hypertriglyceridemia in Taiwanese. Clin Chim Acta. 2008;390:56-62 pubmed publisher
    Apolipoprotein A5 gene (APOA5) has been shown to modulate plasma triglyceride concentrations. We investigated 2 distinct APOA1/C3/A5 haplotypes roles for hypertriglyceridemia...
  33. O Brien P, Alborn W, Sloan J, Ulmer M, Boodhoo A, Knierman M, et al. The novel apolipoprotein A5 is present in human serum, is associated with VLDL, HDL, and chylomicrons, and circulates at very low concentrations compared with other apolipoproteins. Clin Chem. 2005;51:351-9 pubmed
    The recently discovered apolipoprotein A5 (ApoA5) is fast gaining attention as a key regulator of serum triglyceride concentrations...
  34. Jaromi L, Csongei V, Polgar N, Szolnoki Z, Maasz A, Horvatovich K, et al. Functional variants of glucokinase regulatory protein and apolipoprotein A5 genes in ischemic stroke. J Mol Neurosci. 2010;41:121-8 pubmed publisher
    Both the natural variants of the apolipoprotein A5 (APOA5) and the glucokinase regulatory protein gene (GCKR) have been shown to associate with increased fasting triglyceride levels...
  35. Talmud P, Hawe E, Martin S, Olivier M, Miller G, Rubin E, et al. Relative contribution of variation within the APOC3/A4/A5 gene cluster in determining plasma triglycerides. Hum Mol Genet. 2002;11:3039-46 pubmed
    ..Mouse models indicate an inverse relationship between levels of the newly identified apolipoprotein AV (APOAV) and TG concentrations...
  36. Smith C, Tucker K, Lai C, Parnell L, Lee Y, Ordovas J. Apolipoprotein A5 and lipoprotein lipase interact to modulate anthropometric measures in Hispanics of Caribbean origin. Obesity (Silver Spring). 2010;18:327-32 pubmed publisher
    Apolipoprotein A5 (APOA5) and lipoprotein lipase (LPL) proteins interact functionally to regulate lipid metabolism, and single-nucleotide polymorphisms (SNPs) for each gene have also been associated independently with obesity risk...
  37. Wallace C, Newhouse S, Braund P, Zhang F, Tobin M, Falchi M, et al. Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia. Am J Hum Genet. 2008;82:139-49 pubmed publisher
    ..This finding provides a potential biological mechanism for the recent association of this same allele of the same SNP with increased risk of coronary disease. ..
  38. Masana L, Ribalta J, Salazar J, Fernandez Ballart J, Joven J, Cabezas M. The apolipoprotein AV gene and diurnal triglyceridaemia in normolipidaemic subjects. Clin Chem Lab Med. 2003;41:517-21 pubmed
    The newly recognised apolipoprotein (apo) AV gene (APOAV) has been linked to fasting plasma triglyceride (TG) concentrations with some polymorphisms associated with elevated fasting TGs...
  39. Huang M, Wang T, Wang H, Sung Y, Ko Y, Chiang H. The -1131T>C polymorphism in the apolipoprotein A5 gene is related to hypertriglyceridemia in Taiwanese aborigines. Kaohsiung J Med Sci. 2008;24:171-9 pubmed publisher
  40. Talmud P, Cooper J, Hattori H, Miller I, Miller G, Humphries S. The apolipoprotein A-V genotype and plasma apolipoprotein A-V and triglyceride levels: prospective risk of type 2 diabetes. Results from the Northwick Park Heart Study II. Diabetologia. 2006;49:2337-40 pubmed
    We sought to establish the relationship between plasma apolipoprotein A-V (APOA5, previously known as apoA-V) and triglyceride levels and to determine the impact of the APOA5 genotype on APOA5 levels and development of type 2 diabetes in ..
  41. Ong K, Jiang C, Liu B, Jin Y, Tso A, Tam S, et al. Association of a genetic variant in the apolipoprotein A5 gene with the metabolic syndrome in Chinese. Clin Endocrinol (Oxf). 2011;74:206-13 pubmed publisher
    Single nucleotide polymorphisms (SNPs) in the apolipoprotein A5 gene (APOA5) are associated with hypertriglyceridaemia in our population...
  42. Hubacek J, Skodova Z, Lanska V, Adamkova V. Apolipoprotein A-V variant (T-1131>C) affects plasma levels of non-high-density lipoprotein cholesterol in Caucasians. Exp Clin Cardiol. 2008;13:129-32 pubmed
    The importance of apolipoprotein A-V (APOAV) gene variants in the determination of plasma triglyceride levels in humans has been proven in several population studies...
  43. Palmen J, Smith A, Dorfmeister B, Putt W, Humphries S, Talmud P. The functional interaction on in vitro gene expression of APOA5 SNPs, defining haplotype APOA52, and their paradoxical association with plasma triglyceride but not plasma apoAV levels. Biochim Biophys Acta. 2008;1782:447-52 pubmed publisher
    Plasma triglyceride (TG) and apoAV levels are reported to be positively correlated, yet SNPs defining haplotype APOA52 have consistently shown association with elevated plasma triglyceride (TG) but not plasma apoAV levels...
  44. Bi N, Yan S, Li G, Yin Z, Chen B. A single nucleotide polymorphism -1131T>C in the apolipoprotein A5 gene is associated with an increased risk of coronary artery disease and alters triglyceride metabolism in Chinese. Mol Genet Metab. 2004;83:280-6 pubmed
    ..Variants in the newly identified apolipoprotein APOA5 gene were found to be strongly associated with elevated TG levels in different racial groups...
  45. Evans D, Seedorf U, Beil F. Polymorphisms in the apolipoprotein A5 (APOA5) gene and type III hyperlipidemia. Clin Genet. 2005;68:369-72 pubmed
    ..The frequency of two polymorphisms in the APOA5 gene, -1131T>C and S19W, has been determined in 72 hyperlipidemic patients with APOE2/2 genotype attending a ..
  46. Bhaskar S, Ganesan M, Chandak G, Mani R, Idris M, Khaja N, et al. Association of PON1 and APOA5 gene polymorphisms in a cohort of Indian patients having coronary artery disease with and without type 2 diabetes. Genet Test Mol Biomarkers. 2011;15:507-12 pubmed publisher
    ..the association of two selected candidate gene polymorphisms; paraoxonase1 (PON1) Q192R and apolipoprotein A5 (APOA5) -1131T>C were assessed in a cohort of South Indian patients having CAD with and without T2DM...
  47. Liu C, Yang Q, Chen X, Liu C. Apolipoprotein a5 gene polymorphism and risk for metabolic syndrome: a meta-analysis. Genet Test Mol Biomarkers. 2012;16:1241-5 pubmed publisher
    Many studies have focused on the association between the apolipoprotein A5 (ApoA5) polymorphism and the risk of metabolic syndrome (MetS). However, these studies drew inconsistent conclusions...
  48. Hsu L, Ko Y, Chang C, Hu C, Wu S, Teng M, et al. Genetic variations of apolipoprotein A5 gene is associated with the risk of coronary artery disease among Chinese in Taiwan. Atherosclerosis. 2006;185:143-9 pubmed
    Recently, a T/C polymorphism of the promoter region of the APOA5 gene at position -1131 and a G/T polymorphism at position 553 were found to be associated with increased levels of plasma triglyceride...
  49. Niculescu L, Vladica M, Sima A. Association of APOA5 and APOC3 gene polymorphisms with plasma apolipoprotein A5 level in patients with metabolic syndrome. Biochem Biophys Res Commun. 2010;391:587-91 pubmed publisher
    Apolipoprotein A5 gene (APOA5) variants are associated with increased plasma triglycerides, a risk factor for the metabolic syndrome (MS), but a correlation with apolipoprotein C3 (APOC3) genotypes is controversial...
  50. Song K, Cha S, Yu S, Yu H, Oh S, Kang N. Association of apolipoprotein A5 gene -1131T>C polymorphism with the risk of metabolic syndrome in Korean subjects. Biomed Res Int. 2013;2013:585134 pubmed publisher
    We assessed the associations between the APOA5??-1131T>C polymorphism and lipid parameters and other risk factors of the metabolic syndrome in Korean subjects...
  51. Wang J, Ban M, Kennedy B, Anand S, Yusuf S, Huff M, et al. APOA5 genetic variants are markers for classic hyperlipoproteinemia phenotypes and hypertriglyceridemia. Nat Clin Pract Cardiovasc Med. 2008;5:730-7 pubmed publisher
    ..In an attempt to identify other useful variants, we evaluated the association of two common APOA5 single-nucleotide polymorphisms across the range of classic hyperlipoproteinemia phenotypes...
  52. Baum L, Ng M, So W, Poon E, Wang Y, Lam V, et al. A case-control study of apoA5 -1131T-->C polymorphism that examines the role of triglyceride levels in diabetic nephropathy. J Diabetes Complications. 2007;21:158-63 pubmed
    ..The apolipoprotein A5 (apoA5) -1131T-->C polymorphism has a large effect on the TG level, and all three genotypes are relatively common in ..
  53. Ariza M, Sánchez Chaparro M, Barón F, Hornos A, Calvo Bonacho E, Rioja J, et al. Additive effects of LPL, APOA5 and APOE variant combinations on triglyceride levels and hypertriglyceridemia: results of the ICARIA genetic sub-study. BMC Med Genet. 2010;11:66 pubmed publisher
    ..of several genetic variants in genes related with triglyceride (TG) metabolism has been described, including LPL, APOA5 and APOE...
  54. Ken Dror G, Goldbourt U, Dankner R. Different effects of apolipoprotein A5 SNPs and haplotypes on triglyceride concentration in three ethnic origins. J Hum Genet. 2010;55:300-7 pubmed publisher
    Several polymorphisms in the ApoA5 gene emerged as important candidate genes in triglyceride metabolism...
  55. Nabika T, Nasreen S, Kobayashi S, Masuda J. The genetic effect of the apoprotein AV gene on the serum triglyceride level in Japanese. Atherosclerosis. 2002;165:201-4 pubmed
    The newly identified apoprotein AV (apoAV) gene was suggested to have a significant effect on triglyceride (TG) metabolism in Caucasians. We studied the genetic effect of this gene on serum TG in a Japanese population...
  56. Lai C, Demissie S, Cupples L, Zhu Y, Adiconis X, Parnell L, et al. Influence of the APOA5 locus on plasma triglyceride, lipoprotein subclasses, and CVD risk in the Framingham Heart Study. J Lipid Res. 2004;45:2096-105 pubmed
    Several polymorphisms in the APOA5 gene have been associated with increased plasma triglyceride (TG) concentrations...
  57. Guardiola M, Ribalta J, Gómez Coronado D, Lasunción M, de Oya M, Garces C. The apolipoprotein A5 (APOA5) gene predisposes Caucasian children to elevated triglycerides and vitamin E (Four Provinces Study). Atherosclerosis. 2010;212:543-7 pubmed publisher
    ..The aim of this study was to analyse the effect of APOA5 on lipid profiles and fat-soluble vitamins (due to its strong relationship with triglyceride metabolism) in ..
  58. Hallman D, Srinivasan S, Chen W, Boerwinkle E, Berenson G. Longitudinal analysis of haplotypes and polymorphisms of the APOA5 and APOC3 genes associated with variation in serum triglyceride levels: the Bogalusa Heart Study. Metabolism. 2006;55:1574-81 pubmed
    Polymorphisms in the APOC3 and APOA5 genes, from the APOA1/APOC3/APOA4/APOA5 gene cluster on chromosome 11q23, have been associated with interindividual variation in plasma triglycerides...
  59. Ahituv N, Akiyama J, Chapman Helleboid A, Fruchart J, Pennacchio L. In vivo characterization of human APOA5 haplotypes. Genomics. 2007;90:674-9 pubmed
    ..We thus sought to investigate the effects of these minor haplotypes (APOA5*2 and APOA5*3) on ApoAV plasma levels through the precise insertion of single-copy APOA5 haplotypes at a targeted location (Hprt) in the ..
  60. Lee K, Kim O, Lim H, Lee Y, Jang Y, Lee J. Contribution of APOA5-1131C allele to the increased susceptibility of diabetes mellitus in association with higher triglyceride in Korean women. Metabolism. 2010;59:1583-90 pubmed publisher
    Apolipoprotein A5 (APOA5) -1131C allele is associated with higher triglyceride, an independent cardiovascular risk factor and a commonly recognized lipid abnormality in diabetes mellitus (DM)...
  61. Komurcu Bayrak E, Onat A, Poda M, Humphries S, Palmen J, Guclu F, et al. Gender-modulated impact of apolipoprotein A5 gene (APOA5) -1131T>C and c.56C>G polymorphisms on lipids, dyslipidemia and metabolic syndrome in Turkish adults. Clin Chem Lab Med. 2008;46:778-84 pubmed publisher
    Apolipoprotein A5 (APOA5) gene polymorphisms are usually associated with plasma triglyceride levels. We evaluated the relationship of the APOA5 -1131T>C and c...
  62. Barbosa F, de Labio R, de Oliveira S Rigolin V, Minett T, Bertolucci P, de Arruda Cardoso Smith M, et al. Apolipoprotein A-V gene polymorphism -1131T>C and Alzheimer's disease. J Alzheimers Dis. 2006;10:365-9 pubmed
    ..b>APOA5 is a recently discovered apolipoprotein involved primarily with triglyceride (TG) metabolism disorder...
  63. Talmud P, Palmen J, Putt W, Lins L, Humphries S. Determination of the functionality of common APOA5 polymorphisms. J Biol Chem. 2005;280:28215-20 pubmed
    Common variants of APOA5 have consistently shown association with differences in plasma triglyceride (TG) levels...
  64. Hubacek J, Bohuslavova R, Skodova Z, Pitha J, Bobkova D, Poledne R. Polymorphisms in the APOA1/C3/A4/A5 gene cluster and cholesterol responsiveness to dietary change. Clin Chem Lab Med. 2007;45:316-20 pubmed
    ..APOA1 (G-75>A and C83>T), APOC3 (C-482>T and C3238>G), APOA4 (Thr347>Ser and Gln360His) and APOA5 (T-1131>C, Ser19>Trp and Val153>Met) variants were analyzed by PCR and restriction analysis...
  65. Austin M, Talmud P, Farin F, Nickerson D, Edwards K, Leonetti D, et al. Association of apolipoprotein A5 variants with LDL particle size and triglyceride in Japanese Americans. Biochim Biophys Acta. 2004;1688:1-9 pubmed
    A new apolipoprotein (apo) gene, APOA5, was recently identified on chromosome 11q23, and common variants in the gene have been associated with plasma triglyceride (TG) levels in several studies...
  66. Hubacek J, Adamkova V, Ceska R, Poledne R, Horinek A, Vrablik M. New variants in the apolipoprotein AV gene in individuals with extreme triglyceride levels. Physiol Res. 2004;53:225-8 pubmed
    Animal studies (on transgenic and knock-out mice) and human association analysis assessed the importance of APOAV gene for plasma triglyceride determination...
  67. Grallert H, Sedlmeier E, Huth C, Kolz M, Heid I, Meisinger C, et al. APOA5 variants and metabolic syndrome in Caucasians. J Lipid Res. 2007;48:2614-21 pubmed
    Apolipoprotein A5 (APOA5) gene variants were reported to be associated with two components of metabolic syndrome (MetS): higher TG levels and lower HDL levels...
  68. Yin R, Li Y, Lai C. Apolipoprotein A1/C3/A5 haplotypes and serum lipid levels. Lipids Health Dis. 2011;10:140 pubmed publisher
    ..Genotyping of the ApoA1 -75 bp G>A, ApoC3 3238C>G, ApoA5 -1131T>C, ApoA5 c.553G>T and ApoA5 c...
  69. Hubacek J, Adamkova V, Prusikova M, Snejdrlova M, Hirschfeldova K, Lanska V, et al. Impact of apolipoprotein A5 variants on statin treatment efficacy. Pharmacogenomics. 2009;10:945-50 pubmed publisher
    ..However, this has not been analyzed before. We examined the putative association between APOA5 SNPs (c.-1131T>C, c.56C>G and c...
  70. Yamada Y, Ichihara S, Kato K, Yoshida T, Yokoi K, Matsuo H, et al. Genetic risk for metabolic syndrome: examination of candidate gene polymorphisms related to lipid metabolism in Japanese people. J Med Genet. 2008;45:22-8 pubmed
    ..adjustment for age, sex and smoking status found that the-3A-->G and 553G-->T (Gly185Cys) polymorphisms of APOA5, the 2052T-->C (Val653Val) and 1866C-->T (Asn591Asn) polymorphisms of LDLR, the 13989A-->G (Ile118Val) ..
  71. Prieur X, Coste H, Rodriguez J. The human apolipoprotein AV gene is regulated by peroxisome proliferator-activated receptor-alpha and contains a novel farnesoid X-activated receptor response element. J Biol Chem. 2003;278:25468-80 pubmed
    The newly identified apolipoprotein AV (apoAV) gene is a key player in determining plasma triglyceride concentrations...
  72. Ferrucci L, Perry J, Matteini A, Perola M, Tanaka T, Silander K, et al. Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study. Am J Hum Genet. 2009;84:123-33 pubmed publisher
    ..05). The SNP rs12272004, in linkage disequilibrium with the S19W variant in the APOA5 gene, was associated with alpha-tocopherol (meta-analysis p = 7...
  73. Sánchez Moreno C, Ordovas J, Smith C, Baraza J, Lee Y, Garaulet M. APOA5 gene variation interacts with dietary fat intake to modulate obesity and circulating triglycerides in a Mediterranean population. J Nutr. 2011;141:380-5 pubmed publisher
    b>APOA5 is one of the strongest regulators of plasma TG concentrations; nevertheless, its mechanisms of action are poorly characterized...
  74. Klos K, Sing C, Boerwinkle E, Hamon S, Rea T, Clark A, et al. Consistent effects of genes involved in reverse cholesterol transport on plasma lipid and apolipoprotein levels in CARDIA participants. Arterioscler Thromb Vasc Biol. 2006;26:1828-36 pubmed
    ..To identify common variations in genes in the reverse cholesterol transport pathway with nongender-specific influence on plasma lipid and apolipoprotein levels...
  75. Can Demirdöğen B, Sahin E, Türkanoğlu Özçelik A, Bek S, Demirkaya S, Adali O. Apolipoprotein A5 polymorphisms in Turkish population: association with serum lipid profile and risk of ischemic stroke. Mol Biol Rep. 2012;39:10459-68 pubmed publisher
    ..Apolipoprotein A5 (APOA5) genetic polymorphisms are associated with altered TG levels...
  76. Weinberg R, Cook V, Beckstead J, Martin D, Gallagher J, Shelness G, et al. Structure and interfacial properties of human apolipoprotein A-V. J Biol Chem. 2003;278:34438-44 pubmed
    ..Given that overexpression of the apoA-V gene lowers plasma triglycerides in mice, these data together suggest that apoA-V may function intracellularly to modulate hepatic VLDL synthesis and/or secretion. ..
  77. Sóter M, Gomes K, Fernandes A, Carvalho M, Pinheiro P, Bosco A, et al. -1131T>C and SW19 polymorphisms in APOA5 gene and lipid levels in type 2 diabetic patients. Mol Biol Rep. 2012;39:7541-8 pubmed publisher
    ..Polymorphisms in Apolipoprotein A5 gene (APOA5) have been associated with increased triglyceride levels in many different populations...
  78. Chandak G, Ward K, Yajnik C, Pandit A, Bavdekar A, Joglekar C, et al. Triglyceride associated polymorphisms of the APOA5 gene have very different allele frequencies in Pune, India compared to Europeans. BMC Med Genet. 2006;7:76 pubmed
    The APOA5 gene variants, -1131T>C and S19W, are associated with altered triglyceride concentrations in studies of subjects of Caucasian and East Asian descent. There are few studies of these variants in South Asians...
  79. Calandra S, Priore Oliva C, Tarugi P, Bertolini S. APOA5 and triglyceride metabolism, lesson from human APOA5 deficiency. Curr Opin Lipidol. 2006;17:122-7 pubmed
    ..we compare the phenotype and lipoprotein abnormalities of some patients who were found to carry mutations in the APOA5 gene predicted to result in apolipoprotein A-V deficiency...
  80. Jang Y, Chae J, Kim O, Park H, Kim J, Paik J, et al. APOA5-1131T>C genotype effects on apolipoprotein A5 and triglyceride levels in response to dietary intervention and regular exercise (DIRE) in hypertriglyceridemic subjects. Atherosclerosis. 2010;211:512-9 pubmed publisher
    We aimed to determine the influence of apolipoprotein A5 gene (APOA5)-1131T>C single nucleotide polymorphism on the effects of dietary intervention and regular exercise (DIRE) targeting ApoA5 and triglyceride (TG) concentrations...
  81. Olano Martin E, Abraham E, Gill Garrison R, Valdes A, Grimaldi K, Tang F, et al. Influence of apoA-V gene variants on postprandial triglyceride metabolism: impact of gender. J Lipid Res. 2008;49:945-53 pubmed publisher
    ..015). However, in linear regression analysis, a significant independent association with TG AUC (P = 0.007) was only evident for the apoA-V -1131 T>C SNP, indicating a greater relative importance of the apoA-V genotype. ..
  82. van der Vliet H, Sammels M, Leegwater A, Levels J, Reitsma P, Boers W, et al. Apolipoprotein A-V: a novel apolipoprotein associated with an early phase of liver regeneration. J Biol Chem. 2001;276:44512-20 pubmed
    ..Therefore, we have identified a novel apolipoprotein, designated apolipoprotein A-V, that is associated with an early phase of liver regeneration. ..
  83. Hishida A, Morita E, Naito M, Okada R, Wakai K, Matsuo K, et al. Associations of apolipoprotein A5 (APOA5), glucokinase (GCK) and glucokinase regulatory protein (GCKR) polymorphisms and lifestyle factors with the risk of dyslipidemia and dysglycemia in Japanese - a cross-sectional data from the J-MICC Study. Endocr J. 2012;59:589-99 pubmed
    This study examined the associations of the APOA5 T-1131C (rs662799), G553T (Cys185Gly, rs2075291), GCK G-30A (rs1799884), GCKR A/G at intron 16 (rs780094) and T1403C (Leu446Pro, rs1260326) polymorphisms with serum lipid and glucose ..
  84. Lai C, Corella D, Demissie S, Cupples L, Adiconis X, Zhu Y, et al. Dietary intake of n-6 fatty acids modulates effect of apolipoprotein A5 gene on plasma fasting triglycerides, remnant lipoprotein concentrations, and lipoprotein particle size: the Framingham Heart Study. Circulation. 2006;113:2062-70 pubmed
    Apolipoprotein A5 gene (APOA5) variation is associated with plasma triglycerides (TGs). However, little is known about whether dietary fat modulates this association...
  85. Moreno R, Perez Jimenez F, Marin C, Moreno J, Gomez P, Bellido C, et al. A single nucleotide polymorphism of the apolipoprotein A-V gene -1131T>C modulates postprandial lipoprotein metabolism. Atherosclerosis. 2006;189:163-8 pubmed
    ..The modifications observed in postprandial lipoprotein metabolism in subjects with the apoA-V -1131T>C polymorphism could be involved in the increased fasting plasma TG concentrations previously described in carriers of the C allele. ..
  86. Yu Y, Xue L, Zhao C. [Study on polymorphism in the apolipoprotein A5 gene in patients with premature coronary heart disease]. Beijing Da Xue Xue Bao Yi Xue Ban. 2007;39:576-80 pubmed
    To investigate the association between the apolipoprotein A5(APOA5) -1131T/C polymorphism and premature coronary heart disease in northern Chinese Han population...
  87. Jakel H, Nowak M, Helleboid Chapman A, Fruchart Najib J, Fruchart J. Is apolipoprotein A5 a novel regulator of triglyceride-rich lipoproteins?. Ann Med. 2006;38:2-10 pubmed
    ..Recently, apolipoprotein A5 (APOA5) was identified as a novel member of the APOA1/C3/A4 gene cluster...