APC

Summary

Gene Symbol: APC
Description: APC, WNT signaling pathway regulator
Alias: BTPS2, DP2, DP2.5, DP3, PPP1R46, adenomatous polyposis coli protein, WNT signaling pathway regulator, adenomatosis polyposis coli tumor suppressor, adenomatous polyposis coli (APC), deleted in polyposis 2.5, protein phosphatase 1, regulatory subunit 46, truncated adenomatosis polyposis coli
Species: human
Products:     APC

Top Publications

  1. Liu J, Xing Y, Hinds T, Zheng J, Xu W. The third 20 amino acid repeat is the tightest binding site of APC for beta-catenin. J Mol Biol. 2006;360:133-44 pubmed
    Adenomatous polyposis coli (APC) plays a critical role in the Wnt signaling pathway by tightly regulating beta-catenin turnover and localization...
  2. Nieuwenhuis M, Mathus Vliegen L, Slors F, Griffioen G, Nagengast F, Schouten W, et al. Genotype-phenotype correlations as a guide in the management of familial adenomatous polyposis. Clin Gastroenterol Hepatol. 2007;5:374-8 pubmed
    ..Rectal cancer risk is eliminated by IPAA, but complication rate is higher than in IRA. Mutation analysis might predict severity of polyposis and be helpful in the surgical decision...
  3. Seo E, Jho E. Axin-independent phosphorylation of APC controls beta-catenin signaling via cytoplasmic retention of beta-catenin. Biochem Biophys Res Commun. 2007;357:81-6 pubmed
    It has been shown that accumulation of free beta-catenin leads to mobility shift of adenomatous polyposis coli (APC) protein and that Axin facilitates this process...
  4. Bougatef K, Ouerhani S, Moussa A, Kourda N, Coulet F, Colas C, et al. Prevalence of mutations in APC, CTNNB1, and BRAF in Tunisian patients with sporadic colorectal cancer. Cancer Genet Cytogenet. 2008;187:12-8 pubmed publisher
    Sporadic colorectal tumorigenesis is caused by alterations in the Wnt (APC, CTNNB1) and Ras pathways. Our objective was to analyze the occurrence of these genetic alterations in relation to tumor and patient characteristics...
  5. Su Y, Fu C, Ishikawa S, Stella A, Kojima M, Shitoh K, et al. APC is essential for targeting phosphorylated beta-catenin to the SCFbeta-TrCP ubiquitin ligase. Mol Cell. 2008;32:652-61 pubmed publisher
    ..is highly vulnerable to protein phosphatase 2A (PP2A) and must be protected by the adenomatous polyposis coli (APC) tumor suppressor protein...
  6. Chen S, Tsai S, Jao S, Huang Y, Chao Y, Chen Y, et al. Single nucleotide polymorphisms of the APC gene and colorectal cancer risk: a case-control study in Taiwan. BMC Cancer. 2006;6:83 pubmed
    ..Mutation of the adenomatous polyposis coli (APC) gene, a tumour suppressor, is thought to be an early event in colorectal tumourigenesis...
  7. Aretz S, Stienen D, Friedrichs N, Stemmler S, Uhlhaas S, Rahner N, et al. Somatic APC mosaicism: a frequent cause of familial adenomatous polyposis (FAP). Hum Mutat. 2007;28:985-92 pubmed
    ..During APC mutation screening in 1,248 unrelated patients with familial adenomatous polyposis (FAP), we identified 75 cases ..
  8. Huang S, Ting W, Chen L, Huang L, Liu C, Chen C, et al. Association analysis of Wnt pathway genes on prostate-specific antigen recurrence after radical prostatectomy. Ann Surg Oncol. 2010;17:312-22 pubmed publisher
    ..We comprehensively studied the contribution of genetic variations in CTNNB1 and adenomatous polyposis coli (APC), one of the key genes encoding the CTNNB1 destruction complex, to PCa risk and prognosis after RP using a hospital-..
  9. Kohler E, Derungs A, Daum G, Behrens J, Schneikert J. Functional definition of the mutation cluster region of adenomatous polyposis coli in colorectal tumours. Hum Mol Genet. 2008;17:1978-87 pubmed publisher
    The mutation cluster region (MCR) of adenomatous polyposis coli (APC) is located within the central part of the open reading frame, overlapping with the region encoding the 20 amino acid repeats (20R) that are beta-catenin-binding sites...

More Information

Publications103 found, 100 shown here

  1. Azzopardi D, Dallosso A, Eliason K, Hendrickson B, Jones N, Rawstorne E, et al. Multiple rare nonsynonymous variants in the adenomatous polyposis coli gene predispose to colorectal adenomas. Cancer Res. 2008;68:358-63 pubmed publisher
    ..We have studied this hypothesis by sequencing the adenomatous polyposis coli (APC) gene in 691 unrelated North American patients with CRAs and 969 matched healthy controls...
  2. Lee B, Lee E, Jung E, Chun H, Chang D, Song S, et al. Aberrant methylation of APC, MGMT, RASSF2A, and Wif-1 genes in plasma as a biomarker for early detection of colorectal cancer. Clin Cancer Res. 2009;15:6185-91 pubmed publisher
    ..Of the 243 colorectal cancer tissues, methylation was detected in 18% for p14, 34% for p16, 27% for APC, 34% for DAPK, 32% for HLTF, 21% for hMLH1, 39% for MGMT, 24% for RARbeta2, 58% for RASSF2A, and 74% for Wif-1...
  3. Andresen P, Heimdal K, Aaberg K, Eklo K, Eklo K, Ariansen S, et al. APC mutation spectrum of Norwegian familial adenomatous polyposis families: high ratio of novel mutations. J Cancer Res Clin Oncol. 2009;135:1463-70 pubmed publisher
    ..polyposis (FAP) is an autosomal dominantly inherited disease caused by mutations in the adenomatous polyposis coli (APC) gene...
  4. Stekrova J, Sulova M, Kebrdlova V, Zidkova K, Kotlas J, Ilencikova D, et al. Novel APC mutations in Czech and Slovak FAP families: clinical and genetic aspects. BMC Med Genet. 2007;8:16 pubmed
    Germline mutations in the adenomatous polyposis gene (APC) result in familial adenomatous polyposis (FAP). FAP is an autosomal dominantly inherited disorder predisposing to colorectal cancer...
  5. Wang H, Promkan M, Liu G, Chakrabarty S. Switch of transforming growth factor beta function from tumor suppression to stimulation in adenomatous polyposis coli (APC) knocked-down human colon carcinoma cells. Cancer Lett. 2008;272:253-9 pubmed publisher
    ..Both the CBS and Moser cells were found to express mutant (truncated) APC. Expression of this form of APC did not interfere with the tumor-suppressive function of TGFbeta...
  6. Prasad C, Mirza S, Sharma G, Prashad R, Dattagupta S, Rath G, et al. Epigenetic alterations of CDH1 and APC genes: relationship with activation of Wnt/beta-catenin pathway in invasive ductal carcinoma of breast. Life Sci. 2008;83:318-25 pubmed publisher
    ..Herein, we analyzed promoter methylation status of CDH1 and Adenomatous polyposis coli (APC) genes in 50 IDCs and correlated with expression of E-cadherin (E-CD) and APC proteins and with activation of ..
  7. Yamulla R, Kane E, Moody A, Politi K, Lock N, Foley A, et al. Testing models of the APC tumor suppressor/?-catenin interaction reshapes our view of the destruction complex in Wnt signaling. Genetics. 2014;197:1285-302 pubmed publisher
    ..The tumor suppressor adenomatous polyposis coli (APC) is an essential negative regulator of Wnt signaling inactivated in >80% of colorectal cancers...
  8. Phelps R, Chidester S, Dehghanizadeh S, Phelps J, Sandoval I, Rai K, et al. A two-step model for colon adenoma initiation and progression caused by APC loss. Cell. 2009;137:623-34 pubmed publisher
    Aberrant Wnt/beta-catenin signaling following loss of the tumor suppressor adenomatous polyposis coli (APC) is thought to initiate colon adenoma formation...
  9. Sierra J, Yoshida T, Joazeiro C, Jones K. The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes. Genes Dev. 2006;20:586-600 pubmed
    The APC tumor suppressor controls the stability and nuclear export of beta-catenin (beta-cat), a transcriptional coactivator of LEF-1/TCF HMG proteins in the Wnt/Wg signaling pathway...
  10. Schneikert J, Behrens J. Truncated APC is required for cell proliferation and DNA replication. Int J Cancer. 2006;119:74-9 pubmed
    The tumour suppressor APC is truncated in most colon cancers, which leads to the stabilization of beta-catenin and to the constitutive activation of Wnt signalling...
  11. Akiyama T, Kawasaki Y. Wnt signalling and the actin cytoskeleton. Oncogene. 2006;25:7538-44 pubmed
    The tumour suppressor adenomatous polyposis coli (APC) is mutated in sporadic and familial colorectal tumours. APC binds to beta-catenin, a key component of the Wnt signalling pathway, and induces its degradation...
  12. Fu X, Li J, Li K, Tian X, Zhang Y. Hypermethylation of APC promoter 1A is associated with moderate activation of Wnt signalling pathway in a subset of colorectal serrated adenomas. Histopathology. 2009;55:554-63 pubmed publisher
    ..This study investigated immunoreactivities of adenomatous polyposis coli (APC) and beta-catenin, mutations of APC and beta-catenin genes, methylation status of APC promoter 1A in 12 SAs, and ..
  13. Albuquerque C, Baltazar C, Filipe B, Penha F, Pereira T, Smits R, et al. Colorectal cancers show distinct mutation spectra in members of the canonical WNT signaling pathway according to their anatomical location and type of genetic instability. Genes Chromosomes Cancer. 2010;49:746-59 pubmed publisher
    ..We have previously shown that in familial adenomatous polyposis, APC somatic mutations are selected to provide the "just-right" level of WNT signaling for tumor formation...
  14. Senda T, Iizuka Kogo A, Onouchi T, Shimomura A. Adenomatous polyposis coli (APC) plays multiple roles in the intestinal and colorectal epithelia. Med Mol Morphol. 2007;40:68-81 pubmed
    The adenomatous polyposis coli (APC) gene is mutated in familial adenomatous polyposis and in most sporadic colorectal tumors...
  15. Kohler E, Brauburger K, Behrens J, Schneikert J. Contribution of the 15 amino acid repeats of truncated APC to beta-catenin degradation and selection of APC mutations in colorectal tumours from FAP patients. Oncogene. 2010;29:1663-71 pubmed publisher
    The adenomatous polyposis coli (APC) protein is a negative regulator of the mitogenic transcription factor beta-catenin by stimulating its proteasomal degradation...
  16. Tran H, Polakis P. Reversible modification of adenomatous polyposis coli (APC) with K63-linked polyubiquitin regulates the assembly and activity of the ?-catenin destruction complex. J Biol Chem. 2012;287:28552-63 pubmed publisher
    The adenomatous polyposis coli (APC) tumor suppressor forms a complex with Axin and GSK3? to promote the phosphorylation and degradation of ?-catenin, a key co-activator of Wnt-induced transcription...
  17. de Vogel S, Weijenberg M, Herman J, Wouters K, de Goeij A, van den Brandt P, et al. MGMT and MLH1 promoter methylation versus APC, KRAS and BRAF gene mutations in colorectal cancer: indications for distinct pathways and sequence of events. Ann Oncol. 2009;20:1216-22 pubmed publisher
    ..DNA methyltransferase (MGMT) and Human Mut-L Homologue 1 (MLH1) promoter hypermethylation are associated with APC, KRAS and BRAF mutations among 734 CRC patients...
  18. Rohlin A, Engwall Y, Fritzell K, Göransson K, Bergsten A, Einbeigi Z, et al. Inactivation of promoter 1B of APC causes partial gene silencing: evidence for a significant role of the promoter in regulation and causative of familial adenomatous polyposis. Oncogene. 2011;30:4977-89 pubmed publisher
    Familial adenomatous polyposis (FAP) is caused by germline mutations in the adenomatous polyposis coli (APC) gene...
  19. Gómez Fernández N, Castellvi Bel S, Fernández Rozadilla C, Balaguer F, Muñoz J, Madrigal I, et al. Molecular analysis of the APC and MUTYH genes in Galician and Catalonian FAP families: a different spectrum of mutations?. BMC Med Genet. 2009;10:57 pubmed publisher
    ..polyposis (FAP) is an autosomal dominant-inherited colorectal cancer syndrome, caused by germline mutations in the APC gene...
  20. Valvezan A, Zhang F, Diehl J, Klein P. Adenomatous polyposis coli (APC) regulates multiple signaling pathways by enhancing glycogen synthase kinase-3 (GSK-3) activity. J Biol Chem. 2012;287:3823-32 pubmed publisher
    ..As Adenomatous Polyposis Coli (APC) functions in many of the same processes, we investigated a role for APC in the regulation of GSK-3-dependent ..
  21. Choi H, Huber A, Weis W. Thermodynamics of beta-catenin-ligand interactions: the roles of the N- and C-terminal tails in modulating binding affinity. J Biol Chem. 2006;281:1027-38 pubmed
    ..beta-catenin is present in a multiprotein complex containing the proteins axin and adenomatous polyposis coli (APC), both of which bind directly to beta-catenin...
  22. Plawski A, Nowakowska D, Podralska M, Lipinski D, Steffen J, Slomski R. The AAPC case, with an early onset of colorectal cancer. Int J Colorectal Dis. 2007;22:449-51 pubmed
    ..The AAPC syndrome is associated with mutations at the 5' region of the APC gene...
  23. Draviam V, Shapiro I, Aldridge B, Sorger P. Misorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1- or APC-depleted cells. EMBO J. 2006;25:2814-27 pubmed
    ..We find that RNAi-mediated depletion of two kMAPs, the adenomatous polyposis coli protein (APC) and its binding partner, EB1, are unusual in affecting the movement and orientation of paired ..
  24. Schneikert J, Brauburger K, Behrens J. APC mutations in colorectal tumours from FAP patients are selected for CtBP-mediated oligomerization of truncated APC. Hum Mol Genet. 2011;20:3554-64 pubmed publisher
    The germline transmission of a mutation in the adenomatous polyposis coli (APC) gene leads to cancer of the gastro-intestinal tract upon somatic inactivation of the remaining allele in familial adenomatous polyposis (FAP) patients...
  25. Ferrarese A, Marin O, Bustos V, Venerando A, Antonelli M, Allende J, et al. Chemical dissection of the APC Repeat 3 multistep phosphorylation by the concerted action of protein kinases CK1 and GSK3. Biochemistry. 2007;46:11902-10 pubmed
    ..in machinery controlled by Wnt signaling is the association of beta-catenin with the adenomatous polyposis coli (APC) protein, which is essential for the degradation of beta-catenin and requires the multiple phosphorylation of APC ..
  26. Mehrotra J, Varde S, Wang H, Chiu H, Vargo J, Gray K, et al. Quantitative, spatial resolution of the epigenetic field effect in prostate cancer. Prostate. 2008;68:152-60 pubmed
    ..The methylation ratio of GSTP1, APC, RARbeta2, and RASSF1A were measured for all of the 159 cores...
  27. Honnappa S, Gouveia S, Weisbrich A, Damberger F, Bhavesh N, Jawhari H, et al. An EB1-binding motif acts as a microtubule tip localization signal. Cell. 2009;138:366-76 pubmed publisher
    ..that a short polypeptide motif, Ser-x-Ile-Pro (SxIP), is used by numerous +TIPs, including the tumor suppressor APC, the transmembrane protein STIM1, and the kinesin MCAK, for localization to microtubule tips in an EB1-dependent ..
  28. Kohler E, Chandra S, Behrens J, Schneikert J. Beta-catenin degradation mediated by the CID domain of APC provides a model for the selection of APC mutations in colorectal, desmoid and duodenal tumours. Hum Mol Genet. 2009;18:213-26 pubmed publisher
    Biallelic mutation of the ADENOMATOUS POLYPOSIS COLI (APC) gene is a hallmark of sporadic colorectal cancer and colorectal, duodenal and desmoid tumours that develop in familial adenomatous polyposis (FAP) patients...
  29. Liu Z, Yang L, Cui D, Liu B, Zhang X, Ma W, et al. [Methylation status and protein expression of adenomatous polyposis coli (APC) gene in breast cancer]. Ai Zheng. 2007;26:586-90 pubmed
    Protein expression product of adenomatous polyposis coli (APC) gene is an important component of Wnt signal transduction pathway...
  30. Ignatov A, Bischoff J, Ignatov T, Schwarzenau C, Krebs T, Kuester D, et al. APC promoter hypermethylation is an early event in endometrial tumorigenesis. Cancer Sci. 2010;101:321-7 pubmed publisher
    The aim of the current study was to investigate the role of promoter methylation of adenomatous polyposis coli (APC) and epithelial cadherin (E-cadherin) genes in endometrial tumorigenesis...
  31. Kita K, Wittmann T, Nathke I, Waterman Storer C. Adenomatous polyposis coli on microtubule plus ends in cell extensions can promote microtubule net growth with or without EB1. Mol Biol Cell. 2006;17:2331-45 pubmed
    In interphase cells, the adenomatous polyposis coli (APC) protein accumulates on a small subset of microtubules (MTs) in cell protrusions, suggesting that APC may regulate the dynamics of these MTs...
  32. Schneikert J, Grohmann A, Behrens J. Truncated APC regulates the transcriptional activity of beta-catenin in a cell cycle dependent manner. Hum Mol Genet. 2007;16:199-209 pubmed
    Most colon cancer cells express truncated versions of the tumour suppressor Adenomatous Polyposis Coli (APC). These molecules are selected during tumourigenesis for impaired beta-catenin degrading activity...
  33. Gaspar C, Cardoso J, Franken P, Molenaar L, Morreau H, Möslein G, et al. Cross-species comparison of human and mouse intestinal polyps reveals conserved mechanisms in adenomatous polyposis coli (APC)-driven tumorigenesis. Am J Pathol. 2008;172:1363-80 pubmed publisher
    ..The majority of sporadic colorectal cancers are triggered by mutations in the adenomatous polyposis coli (APC) tumor suppressor gene, leading to the constitutive activation of the Wnt/beta-catenin signaling pathway and ..
  34. Harris E, Nelson W. Adenomatous polyposis coli regulates endothelial cell migration independent of roles in beta-catenin signaling and cell-cell adhesion. Mol Biol Cell. 2010;21:2611-23 pubmed publisher
    Adenomatous polyposis coli (APC), a tumor suppressor commonly mutated in cancer, is a cytoskeletal organizer for cell migration and a scaffold for GSK3 beta/CKI-mediated phosphorylation and degradation of the Wnt effector beta-catenin...
  35. Coluccia A, Vacca A, Duñach M, Mologni L, Redaelli S, Bustos V, et al. Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation. EMBO J. 2007;26:1456-66 pubmed
    ..These findings indicate the Bcr-Abl triggered Y phosphorylation of beta-catenin as a new mechanism responsible for its protein stabilization and nuclear signalling activation in CML. ..
  36. Rennert G, Almog R, Tomsho L, Low M, Pinchev M, Chaiter Y, et al. Colorectal polyps in carriers of the APC I1307K polymorphism. Dis Colon Rectum. 2005;48:2317-21 pubmed
    The probability of colorectal cancer is moderately increased among carriers of the APC I1307K polymorphism. However, it is not known if endoscopic surveillance of this high-risk group is warranted...
  37. Kawasaki Y, Sagara M, Shibata Y, Shirouzu M, Yokoyama S, Akiyama T. Identification and characterization of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc42. Oncogene. 2007;26:7620-267 pubmed
    The tumor suppressor adenomatous polyposis coli (APC) is mutated in sporadic and familial colorectal tumors...
  38. Henrique R, Ribeiro F, Fonseca D, Hoque M, Carvalho A, Costa V, et al. High promoter methylation levels of APC predict poor prognosis in sextant biopsies from prostate cancer patients. Clin Cancer Res. 2007;13:6122-9 pubmed
    ..Promoter methylation levels of APC, CCND2, GSTP1, RARB2, and RASSF1A were determined by QMSP in a prospective series of 83 prostate cancer patients ..
  39. Bisgaard M, Bulow S. Familial adenomatous polyposis (FAP): genotype correlation to FAP phenotype with osteomas and sebaceous cysts. Am J Med Genet A. 2006;140:200-4 pubmed
    ..This disorder was regarded as a separate disease until the identification of the APC gene when it was recognized that mutations in the APC gene were the underlying cause of both Gardner syndrome and ..
  40. Jeon C, Lee H, Shin I, Park J. Genetic alterations of APC, K-ras, p53, MSI, and MAGE in Korean colorectal cancer patients. Int J Colorectal Dis. 2008;23:29-35 pubmed
    ..We investigated the presence of adenomatous polyposis coli gene (APC), Kirsten-ras (K-ras), p53, microsatellite instability (MSI), and melanoma antigen gene (MAGE) alterations in CRC ..
  41. Nagel R, le Sage C, Diosdado B, van der Waal M, Oude Vrielink J, Bolijn A, et al. Regulation of the adenomatous polyposis coli gene by the miR-135 family in colorectal cancer. Cancer Res. 2008;68:5795-802 pubmed publisher
    Inactivation of the adenomatous polyposis coli (APC) gene is a major initiating event in colorectal tumorigenesis...
  42. Charames G, Ramyar L, Mitri A, Berk T, Cheng H, Jung J, et al. A large novel deletion in the APC promoter region causes gene silencing and leads to classical familial adenomatous polyposis in a Manitoba Mennonite kindred. Hum Genet. 2008;124:535-41 pubmed publisher
    ..polyposis (FAP) is an autosomal dominant syndrome caused by the inheritance of germline mutations in the APC tumour suppressor gene...
  43. Filipe B, Baltazar C, Albuquerque C, Fragoso S, Lage P, Vitoriano I, et al. APC or MUTYH mutations account for the majority of clinically well-characterized families with FAP and AFAP phenotype and patients with more than 30 adenomas. Clin Genet. 2009;76:242-55 pubmed publisher
    ..Overall, APC or MUTYH mutations were detected in 42/48 (88%), 14/20 (70%) and 10/38 (26%) of FAP, AFAP and MCRA patients, ..
  44. Wang Y, Azuma Y, Friedman D, Coffey R, Neufeld K. Novel association of APC with intermediate filaments identified using a new versatile APC antibody. BMC Cell Biol. 2009;10:75 pubmed publisher
    As a key player in suppression of colon tumorigenesis, Adenomatous Polyposis Coli (APC) has been widely studied to determine its cellular functions...
  45. Picelli S, Zajac P, Zhou X, Edler D, Lenander C, Dalén J, et al. Common variants in human CRC genes as low-risk alleles. Eur J Cancer. 2010;46:1041-8 pubmed publisher
    ..05-1.72), respectively (under the dominant model); while 2 SNPs, rs1800932:A>G (MSH6 P92P) and rs459552:T>A (APC D1822V) seemed to confer a protective effect. The latter, in particular showed an odds ratio of 0.76 (CI=0.60-0...
  46. Iwai S, Katagiri W, Kong C, Amekawa S, Nakazawa M, Yura Y. Mutations of the APC, beta-catenin, and axin 1 genes and cytoplasmic accumulation of beta-catenin in oral squamous cell carcinoma. J Cancer Res Clin Oncol. 2005;131:773-82 pubmed
    The Wnt pathway is involved in carcinogenesis and three regulatory genes of the Wnt pathway, APC, beta-catenin and Axin are mutated in some primary human cancers...
  47. Yang J, Zhang W, Evans P, Chen X, He X, Liu C. Adenomatous polyposis coli (APC) differentially regulates beta-catenin phosphorylation and ubiquitination in colon cancer cells. J Biol Chem. 2006;281:17751-7 pubmed
    Most colorectal cancers have mutations of the adenomatous polyposis coli (APC) gene or the beta-catenin gene that stabilize beta-catenin and activate beta-catenin target genes, leading ultimately to cancer...
  48. Latchford A, Volikos E, Johnson V, Rogers P, Suraweera N, Tomlinson I, et al. APC mutations in FAP-associated desmoid tumours are non-random but not 'just right'. Hum Mol Genet. 2007;16:78-82 pubmed
    Analysis of APC mutations in colonic and duodenal tumours from familial adenomatous polyposis (FAP) patients has shown that the site of the first hit, the germline mutation, can predict the type and position of the somatic mutation or '..
  49. Hamann M, Lubking C, Luchini D, Billadeau D. Asef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation element. Mol Cell Biol. 2007;27:1380-93 pubmed
    ..herein called Asef1) was identified as a Rac1-specific exchange factor stimulated by adenomatous polyposis coli (APC), contributing to colorectal cancer cell metastasis...
  50. Plawski A, Slomski R. APC gene mutations causing familial adenomatous polyposis in Polish patients. J Appl Genet. 2008;49:407-14 pubmed publisher
    ..The occurrence of FAP is associated with mutations in the APC tumour suppressor gene, which was described in 1991...
  51. Caldwell C, Kaplan K. The role of APC in mitosis and in chromosome instability. Adv Exp Med Biol. 2009;656:51-64 pubmed
    The established role of APC in regulating microtubules and actin in polarized epithelia naturally raises the possibility that APC similarly influences the mitotic cytoskeleton...
  52. Chandra S, Wacker I, Appelt U, Behrens J, Schneikert J. A common role for various human truncated adenomatous polyposis coli isoforms in the control of beta-catenin activity and cell proliferation. PLoS ONE. 2012;7:e34479 pubmed publisher
    The tumour suppressor gene adenomatous polyposis coli (APC) is mutated in most colorectal cancer cases, leading to the synthesis of truncated APC products and the stabilization of ?-catenin...
  53. Gay L, Mitrou P, Keen J, Bowman R, Naguib A, Cooke J, et al. Dietary, lifestyle and clinicopathological factors associated with APC mutations and promoter methylation in colorectal cancers from the EPIC-Norfolk study. J Pathol. 2012;228:405-15 pubmed publisher
    The tumour suppressor APC is the most commonly altered gene in colorectal cancer (CRC). Genetic and epigenetic alterations of APC may therefore be associated with dietary and lifestyle risk factors for CRC...
  54. Kroboth K, Newton I, Kita K, Dikovskaya D, Zumbrunn J, Waterman Storer C, et al. Lack of adenomatous polyposis coli protein correlates with a decrease in cell migration and overall changes in microtubule stability. Mol Biol Cell. 2007;18:910-8 pubmed
    Most sporadic colorectal tumors carry truncation mutations in the adenomatous polyposis coli (APC) gene. The APC protein is involved in many processes that govern gut tissue...
  55. Dikovskaya D, Schiffmann D, Newton I, Oakley A, Kroboth K, Sansom O, et al. Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis. J Cell Biol. 2007;176:183-95 pubmed
    Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene initiate a majority of colorectal cancers. Acquisition of chromosomal instability is an early event in these tumors...
  56. De Rosa M, Morelli G, Cesaro E, Duraturo F, Turano M, Rossi G, et al. Alternative splicing and nonsense-mediated mRNA decay in the regulation of a new adenomatous polyposis coli transcript. Gene. 2007;395:8-14 pubmed
    ..adenomatous polyposis (FAP) is a rare precancerous condition caused by mutations in the adenomatous polyposis coli (apc) gene...
  57. Brozek I, Plawski A, Podralska M, Kanka C, Slomski R, Limon J. Thyroid cancer in two siblings with FAP syndrome and APC mutation. Int J Colorectal Dis. 2008;23:331-2 pubmed
  58. Li Z, Kroboth K, Newton I, Nathke I. Novel self-association of the APC molecule affects APC clusters and cell migration. J Cell Sci. 2008;121:1916-25 pubmed publisher
    Truncation mutations in the adenomatous polyposis coli (APC) gene are responsible for familial and sporadic colorectal cancer. APC is a multifunctional protein involved in cell migration, proliferation and differentiation...
  59. Zhang J, Neisa R, Mao Y. Oncogenic Adenomatous polyposis coli mutants impair the mitotic checkpoint through direct interaction with Mad2. Mol Biol Cell. 2009;20:2381-8 pubmed publisher
    ..Adenomatous polyposis coli (APC), a tumor suppressor gene that is commonly mutated in colon cancers, has been suggested in causing CIN; however, ..
  60. Lagarde A, Rouleau E, Ferrari A, Noguchi T, Qiu J, Briaux A, et al. Germline APC mutation spectrum derived from 863 genomic variations identified through a 15-year medical genetics service to French patients with FAP. J Med Genet. 2010;47:721-2 pubmed publisher
    Heterozygous APC germline alteration is responsible for familial adenomatous polyposis, a colon cancer predisposition with almost complete penetrance. Point mutations generally lead to truncated proteins or no protein at all...
  61. Zhang Z, Lin K, Gao L, Chen L, Shi X, Wu G. Crystal structure of the armadillo repeat domain of adenomatous polyposis coli which reveals its inherent flexibility. Biochem Biophys Res Commun. 2011;412:732-6 pubmed publisher
    The conserved armadillo repeat (ARM) domain of adenomatous polyposis coli (APC) protein plays an important role in the recognition of its binding partners...
  62. Cleary S, Kim H, Croitoru M, Redston M, Knight J, Gallinger S, et al. Missense polymorphisms in the adenomatous polyposis coli gene and colorectal cancer risk. Dis Colon Rectum. 2008;51:1467-73; discussion 1473-4 pubmed publisher
    Whereas truncating germline mutations of the adenomatous polyposis coli (APC) gene give rise to familial adenomatous polyposis, missense polymorphisms of APC may confer a weaker risk for colorectal cancer...
  63. Van der Auwera I, Van Laere S, Van den Bosch S, Van den Eynden G, Trinh B, van Dam P, et al. Aberrant methylation of the Adenomatous Polyposis Coli (APC) gene promoter is associated with the inflammatory breast cancer phenotype. Br J Cancer. 2008;99:1735-42 pubmed publisher
    Aberrant methylation of the adenomatous polyposis coli (APC) gene promoter occurs in about 40% of breast tumours and has been correlated with reduced APC protein levels...
  64. Kaufmann A, Vogt S, Uhlhaas S, Stienen D, Kurth I, Hameister H, et al. Analysis of rare APC variants at the mRNA level: six pathogenic mutations and literature review. J Mol Diagn. 2009;11:131-9 pubmed publisher
    ..We characterized six rare APC variants in patients with familial adenomatous polyposis at the mRNA level. APC variants c.531 + 5G>C and c...
  65. Castellsagué E, Gonzalez S, Guino E, Stevens K, Borràs E, Raymond V, et al. Allele-specific expression of APC in adenomatous polyposis families. Gastroenterology. 2010;139:439-47, 447.e1 pubmed publisher
    Germline mutations in the APC gene cause of most cases of familial adenomatous polyposis (FAP) and a lesser proportion of attenuated FAP (AFAP)...
  66. Miclea R, Karperien M, Langers A, Robanus Maandag E, van Lierop A, van der Hiel B, et al. APC mutations are associated with increased bone mineral density in patients with familial adenomatous polyposis. J Bone Miner Res. 2010;25:2624-32 pubmed publisher
    ..Adenomatous polyposis coli (APC) represents the key intracellular gatekeeper of ?-catenin turnover, and heterozygous germ-line mutations in the APC ..
  67. Roberts D, Pronobis M, Poulton J, Waldmann J, Stephenson E, Hanna S, et al. Deconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling. Mol Biol Cell. 2011;22:1845-63 pubmed publisher
    ..The tumor suppressor adenomatous polyposis coli (APC), an essential negative regulator of Wnt signaling, provides a paradigm. APC mutations occur in most colon cancers...
  68. Sieber O, Segditsas S, Knudsen A, Zhang J, Luz J, Rowan A, et al. Disease severity and genetic pathways in attenuated familial adenomatous polyposis vary greatly but depend on the site of the germline mutation. Gut. 2006;55:1440-8 pubmed
    ..polyposis (AFAP) is associated with germline mutations in the 5', 3', and exon 9 of the adenomatous polyposis coli (APC) gene. These mutations probably encode a limited amount of functional APC protein...
  69. Iacopetta B, Grieu F, Li W, Ruszkiewicz A, Caruso M, Moore J, et al. APC gene methylation is inversely correlated with features of the CpG island methylator phenotype in colorectal cancer. Int J Cancer. 2006;119:2272-8 pubmed
    ..The MethyLight assay was used to provide quantitative estimates of MLH1, P16, TIMP3, P14, DAPK and APC methylation levels in 199 unselected colorectal tumours...
  70. Nielsen M, Hes F, Nagengast F, Weiss M, Mathus Vliegen E, Morreau H, et al. Germline mutations in APC and MUTYH are responsible for the majority of families with attenuated familial adenomatous polyposis. Clin Genet. 2007;71:427-33 pubmed
    ..We aimed to assess the presence of germline mutations in the MUTYH and adenomatous polyposis coli (APC) genes in AFAP families and to compare the clinical features between the two causative genes...
  71. Csepregi A, Rocken C, Hoffmann J, Gu P, Saliger S, Muller O, et al. APC promoter methylation and protein expression in hepatocellular carcinoma. J Cancer Res Clin Oncol. 2008;134:579-89 pubmed
    We investigated the impact of promoter methylation on APC protein expression in patients with hepatocellular carcinoma (HCC)...
  72. Brock M, Hooker C, Ota Machida E, Han Y, Guo M, Ames S, et al. DNA methylation markers and early recurrence in stage I lung cancer. N Engl J Med. 2008;358:1118-28 pubmed publisher
    ..H-cadherin gene CDH13, the Ras association domain family 1 gene RASSF1A, and the adenomatous polyposis coli gene APC in tumors and in histologically tumor-negative lymph nodes was associated with tumor recurrence, independently of ..
  73. Segditsas S, Sieber O, Rowan A, Setien F, Neale K, Phillips R, et al. Promoter hypermethylation leads to decreased APC mRNA expression in familial polyposis and sporadic colorectal tumours, but does not substitute for truncating mutations. Exp Mol Pathol. 2008;85:201-6 pubmed publisher
    Germline mutations in the tumour suppressor APC cause familial adenomatous polyposis (FAP), and somatic mutations are common in sporadic colorectal cancers (CRCs)...
  74. Chen S, Chiu S, Wu C, Lin S, Kang J, Chen Y, et al. The association of methylation in the promoter of APC and MGMT and the prognosis of Taiwanese CRC patients. Genet Test Mol Biomarkers. 2009;13:67-71 pubmed publisher
    ..this study was to investigate the association of methylation in the promoter regions of adenomatous polyposis coli (APC) and O(6)-methylguanine-DNA methyltransferase (MGMT) and the survival of Taiwanese colorectal cancer (CRC) subjects ..
  75. Li A, Xing Y, Chan B, Heisterkamp N, Groffen J, Borok Z, et al. Cell type-specific expression of adenomatous polyposis coli in lung development, injury, and repair. Dev Dyn. 2010;239:2288-97 pubmed publisher
    Adenomatous polyposis coli (Apc) is critical for Wnt signaling and cell migration. The current study examined Apc expression during lung development, injury, and repair...
  76. Rivera B, Gonzalez S, Sánchez Tomé E, Blanco I, Mercadillo F, Leton R, et al. Clinical and genetic characterization of classical forms of familial adenomatous polyposis: a Spanish population study. Ann Oncol. 2011;22:903-9 pubmed publisher
    ..Classical familial adenomatous polyposis (FAP) is characterized by the appearance of >100 colorectal adenomas...
  77. Minde D, Anvarian Z, Rüdiger S, Maurice M. Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer?. Mol Cancer. 2011;10:101 pubmed publisher
    Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene strongly predispose to development of gastro-intestinal tumors...
  78. Morishita E, Murayama K, Kato Murayama M, Ishizuka Katsura Y, Tomabechi Y, Hayashi T, et al. Crystal structures of the armadillo repeat domain of adenomatous polyposis coli and its complex with the tyrosine-rich domain of Sam68. Structure. 2011;19:1496-508 pubmed publisher
    Adenomatous polyposis coli (APC) is a tumor suppressor protein commonly mutated in colorectal tumors. APC plays important roles in Wnt signaling and other cellular processes...
  79. Rosenbaum E, Hoque M, Cohen Y, Zahurak M, Eisenberger M, Epstein J, et al. Promoter hypermethylation as an independent prognostic factor for relapse in patients with prostate cancer following radical prostatectomy. Clin Cancer Res. 2005;11:8321-5 pubmed
    To analyze the prognostic significance of six epigenetic biomarkers (APC, Cyclin D2, GSTP1, TIG1, Rassf1A, and RARbeta2 promoter hypermethylation) in a homogeneous group of prostate cancer patients, following radical prostatectomy alone...
  80. Major M, Camp N, Berndt J, Yi X, Goldenberg S, Hubbert C, et al. Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling. Science. 2007;316:1043-6 pubmed
    ..tumors, forms a complex with beta-catenin, AXIN1, beta-TrCP2 (beta-transducin repeat-containing protein 2), and APC (adenomatous polyposis coli)...
  81. Grohmann A, Tanneberger K, Alzner A, Schneikert J, Behrens J. AMER1 regulates the distribution of the tumor suppressor APC between microtubules and the plasma membrane. J Cell Sci. 2007;120:3738-47 pubmed
    b>APC is a multifunctional tumor suppressor protein that negatively controls Wnt signaling, but also regulates cell adhesion and migration by interacting with the plasma membrane and the microtubule cytoskeleton...
  82. Romero Gimenez J, Dopeso H, Blanco I, Guerra Moreno A, Gonzalez S, Vogt S, et al. Germline hypermethylation of the APC promoter is not a frequent cause of familial adenomatous polyposis in APC/MUTYH mutation negative families. Int J Cancer. 2008;122:1422-5 pubmed
    ..Inheritance of a mutant allele of the adenomatous polyposis coli (APC) gene is the cause of approximately 80% of FAP and 20-30% of an attenuated form of FAP (AFAP), whereas mutations in ..
  83. Kanter Smoler G, Fritzell K, Rohlin A, Engwall Y, Hallberg B, Bergman A, et al. Clinical characterization and the mutation spectrum in Swedish adenomatous polyposis families. BMC Med. 2008;6:10 pubmed publisher
    The dominantly inherited condition familial adenomatous polyposis (FAP) is caused by germline mutations in the APC gene. Finding the causative mutations has great implications for the families...
  84. Kastritis E, Murray S, Kyriakou F, Horti M, Tamvakis N, Kavantzas N, et al. Somatic mutations of adenomatous polyposis coli gene and nuclear b-catenin accumulation have prognostic significance in invasive urothelial carcinomas: evidence for Wnt pathway implication. Int J Cancer. 2009;124:103-8 pubmed publisher
    ..We searched for mutations in adenomatous polyposis coli (APC), a key regulator of the pathway, and studied b-catenin expression and interactions with the expression of other ..
  85. Hosoya K, Yamashita S, Ando T, Nakajima T, Itoh F, Ushijima T. Adenomatous polyposis coli 1A is likely to be methylated as a passenger in human gastric carcinogenesis. Cancer Lett. 2009;285:182-9 pubmed publisher
    ..In gastric cancers, promoter 1A of the adenomatous polyposis coli (APC) gene is frequently methylated, and is often discussed as a driver...
  86. Gaujoux S, Pinson S, Gimenez Roqueplo A, Amar L, Ragazzon B, Launay P, et al. Inactivation of the APC gene is constant in adrenocortical tumors from patients with familial adenomatous polyposis but not frequent in sporadic adrenocortical cancers. Clin Cancer Res. 2010;16:5133-41 pubmed publisher
    ..ACT is observed in patients with familial adenomatous polyposis (FAP) with germline APC mutations, as well as in patients with Beckwith-Wiedemann syndrome with Wilms' tumors reported to have WTX somatic ..
  87. Liu L, Kron K, Pethe V, Demetrashvili N, Nesbitt M, Trachtenberg J, et al. Association of tissue promoter methylation levels of APC, TGF?2, HOXD3 and RASSF1A with prostate cancer progression. Int J Cancer. 2011;129:2454-62 pubmed publisher
    ..We correlated quantitative promoter methylation levels of APC, TGF?2 and RASSF1A in 219 radical prostatectomies diagnosed between 1998 and 2001 with clinicopathological follow-..
  88. Pecina Slaus N, Nikuseva Martic T, Zeljko M, Bulat S. Brain metastases exhibit gross deletions of the APC gene. Brain Tumor Pathol. 2011;28:223-8 pubmed publisher
    ..In the present study, the adenomatous polyposis coli (APC) gene was analyzed in a set of human brain metastases...
  89. Jarry J, Brunet J, Laframboise R, Drouin R, Latreille J, Richard C, et al. A survey of APC mutations in Quebec. Fam Cancer. 2011;10:659-65 pubmed publisher
    This is an 11-year survey of molecular analysis of APC germline mutations for the province of Quebec done at the Molecular Pathology Unit of the Jewish General Hospital which offers genetic testing for hereditary forms of colorectal ..
  90. Zhang Z, Chen L, Gao L, Lin K, Zhu L, Lu Y, et al. Structural basis for the recognition of Asef by adenomatous polyposis coli. Cell Res. 2012;22:372-86 pubmed publisher
    Adenomatous polyposis coli (APC) regulates cell-cell adhesion and cell migration through activating the APC-stimulated guanine nucleotide-exchange factor (GEF; Asef), which is usually autoinhibited through the binding between its Src ..
  91. Tran H, Bustos D, Yeh R, Rubinfeld B, Lam C, Shriver S, et al. HectD1 E3 ligase modifies adenomatous polyposis coli (APC) with polyubiquitin to promote the APC-axin interaction. J Biol Chem. 2013;288:3753-67 pubmed publisher
    The adenomatous polyposis coli (APC) protein functions as a negative regulator of the Wnt signaling pathway...
  92. Rusan N, Peifer M. Original CIN: reviewing roles for APC in chromosome instability. J Cell Biol. 2008;181:719-26 pubmed publisher
    ..original sin and still many wonder, where's the evidence? Today, the tumor suppressor adenomatous polyposis coli (APC) may have the same complaint about accusations of a different type of CIN, chromosome instability...