antichymotrypsin

Summary

Gene Symbol: antichymotrypsin
Description: serpin family A member 3
Alias: AACT, ACT, GIG24, GIG25, alpha-1-antichymotrypsin, cell growth-inhibiting gene 24/25 protein, growth-inhibiting protein 24, growth-inhibiting protein 25, serine (or cysteine) proteinase inhibitor, clade A, member 3, serpin A3, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
Species: human
Products:     antichymotrypsin

Top Publications

  1. Slowik A, Borratynska A, Turaj W, Pera J, Dziedzic T, Figlewicz D, et al. Alpha1-antichymotrypsin gene (SERPINA3) A/T polymorphism as a risk factor for aneurysmal subarachnoid hemorrhage. Stroke. 2005;36:737-40 pubmed
    The member 3 of clade A of serine proteinase inhibitors (SERPINA3), known previously as the alpha1-antichymotrypsin, is an acute phase protein, the levels of which increase in acute and chronic inflammation...
  2. Obach V, Revilla M, Vila N, Cervera A A, Chamorro A A. alpha(1)-antichymotrypsin polymorphism: a risk factor for hemorrhagic stroke in normotensive subjects. Stroke. 2001;32:2588-91 pubmed
    ..Preliminary data showed that the TT genotype of the alpha(1)-antichymotrypsin (ACT) gene polymorphism was associated with HS, although it remained unsettled whether prevalence of this ..
  3. Fu Y, Xie R, Wang Y, Chen D, Zhang Y, Wang G, et al. [Association between alpha-1-antichymotrypsin gene polymorphism and cerebral hemorrhage]. Zhonghua Yi Xue Za Zhi. 2002;82:915-7 pubmed
    To explore the association between alpha-1-antichymotrypsin (ACT) gene A/T polymorphism and cerebral hemorrhage among Chinese people...
  4. DeMeo D, Campbell E, Barker A, Brantly M, Eden E, McElvaney N, et al. IL10 polymorphisms are associated with airflow obstruction in severe alpha1-antitrypsin deficiency. Am J Respir Cell Mol Biol. 2008;38:114-20 pubmed
    ..Haplotype analysis of IL10 SNPs suggested the strongest association with IL10 promoter SNPs. IL10 is likely an important modifier gene for the development of COPD in individuals with severe AAT deficiency. ..
  5. Krischek B, Akagawa H, Tajima A, Narita A, Kasuya H, Hori T, et al. The alanine/threonine polymorphism of the alpha-1-antichymotrypsin (SERPINA3) gene and ruptured intracranial aneurysms in the Japanese population. Cerebrovasc Dis. 2007;23:46-9 pubmed
    Serine protease inhibitor member 3 of clade A (SERPINA3), also known as alpha-1-antichymotrypsin, inhibits the activity of cathepsin G...
  6. Poller W, Faber J, Weidinger S, Tief K, Scholz S, Fischer M, et al. A leucine-to-proline substitution causes a defective alpha 1-antichymotrypsin allele associated with familial obstructive lung disease. Genomics. 1993;17:740-3 pubmed
    ..and direct sequencing of amplified genomic DNA, we have identified two defective mutants of the human alpha 1-antichymotrypsin (ACT) gene associated with chronic obstructive pulmonary disease (COPD)...
  7. Pera J, Slowik A, Dziedzic T, Szczudlik A. SERPINA3 polymorphism is not associated with primary intracerebral hemorrhage in a Polish population. Stroke. 2006;37:906-7 pubmed
    ..We failed to find an association between SERPINA3 A/T polymorphism and PICH in a Polish population. ..
  8. Chappell S, Daly L, Morgan K, Guetta Baranes T, Roca J, Rabinovich R, et al. Cryptic haplotypes of SERPINA1 confer susceptibility to chronic obstructive pulmonary disease. Hum Mutat. 2006;27:103-9 pubmed
    ..In contrast, no haplotype associations for SERPINA3 were identified. ..
  9. Borgmann S, Haubitz M, Schwab S. Lack of association of alpha-1 antichymotrypsin gene polymorphism with PR3-ANCA and MPO-ANCA associated vasculitis. Autoimmunity. 2002;35:435-9 pubmed
    ..1 has been described. A1-antichymotrypsin (AACT), part of an extended serpin gene cluster, was discussed to contribute to PR3-ANCA associated ..
  10. Casslen B. Inhibitors of trypsin, chymotrypsin and elastase in human uterine fluid. Acta Obstet Gynecol Scand. 1986;65:121-4 pubmed
    ..and elastase was present in fractions containing alpha 2-macroglobulin, alpha 1-antitrypsin, alpha 1-antichymotrypsin and antileukoprotease...

Detail Information

Publications62

  1. Slowik A, Borratynska A, Turaj W, Pera J, Dziedzic T, Figlewicz D, et al. Alpha1-antichymotrypsin gene (SERPINA3) A/T polymorphism as a risk factor for aneurysmal subarachnoid hemorrhage. Stroke. 2005;36:737-40 pubmed
    The member 3 of clade A of serine proteinase inhibitors (SERPINA3), known previously as the alpha1-antichymotrypsin, is an acute phase protein, the levels of which increase in acute and chronic inflammation...
  2. Obach V, Revilla M, Vila N, Cervera A A, Chamorro A A. alpha(1)-antichymotrypsin polymorphism: a risk factor for hemorrhagic stroke in normotensive subjects. Stroke. 2001;32:2588-91 pubmed
    ..Preliminary data showed that the TT genotype of the alpha(1)-antichymotrypsin (ACT) gene polymorphism was associated with HS, although it remained unsettled whether prevalence of this ..
  3. Fu Y, Xie R, Wang Y, Chen D, Zhang Y, Wang G, et al. [Association between alpha-1-antichymotrypsin gene polymorphism and cerebral hemorrhage]. Zhonghua Yi Xue Za Zhi. 2002;82:915-7 pubmed
    To explore the association between alpha-1-antichymotrypsin (ACT) gene A/T polymorphism and cerebral hemorrhage among Chinese people...
  4. DeMeo D, Campbell E, Barker A, Brantly M, Eden E, McElvaney N, et al. IL10 polymorphisms are associated with airflow obstruction in severe alpha1-antitrypsin deficiency. Am J Respir Cell Mol Biol. 2008;38:114-20 pubmed
    ..Haplotype analysis of IL10 SNPs suggested the strongest association with IL10 promoter SNPs. IL10 is likely an important modifier gene for the development of COPD in individuals with severe AAT deficiency. ..
  5. Krischek B, Akagawa H, Tajima A, Narita A, Kasuya H, Hori T, et al. The alanine/threonine polymorphism of the alpha-1-antichymotrypsin (SERPINA3) gene and ruptured intracranial aneurysms in the Japanese population. Cerebrovasc Dis. 2007;23:46-9 pubmed
    Serine protease inhibitor member 3 of clade A (SERPINA3), also known as alpha-1-antichymotrypsin, inhibits the activity of cathepsin G...
  6. Poller W, Faber J, Weidinger S, Tief K, Scholz S, Fischer M, et al. A leucine-to-proline substitution causes a defective alpha 1-antichymotrypsin allele associated with familial obstructive lung disease. Genomics. 1993;17:740-3 pubmed
    ..and direct sequencing of amplified genomic DNA, we have identified two defective mutants of the human alpha 1-antichymotrypsin (ACT) gene associated with chronic obstructive pulmonary disease (COPD)...
  7. Pera J, Slowik A, Dziedzic T, Szczudlik A. SERPINA3 polymorphism is not associated with primary intracerebral hemorrhage in a Polish population. Stroke. 2006;37:906-7 pubmed
    ..We failed to find an association between SERPINA3 A/T polymorphism and PICH in a Polish population. ..
  8. Chappell S, Daly L, Morgan K, Guetta Baranes T, Roca J, Rabinovich R, et al. Cryptic haplotypes of SERPINA1 confer susceptibility to chronic obstructive pulmonary disease. Hum Mutat. 2006;27:103-9 pubmed
    ..In contrast, no haplotype associations for SERPINA3 were identified. ..
  9. Borgmann S, Haubitz M, Schwab S. Lack of association of alpha-1 antichymotrypsin gene polymorphism with PR3-ANCA and MPO-ANCA associated vasculitis. Autoimmunity. 2002;35:435-9 pubmed
    ..1 has been described. A1-antichymotrypsin (AACT), part of an extended serpin gene cluster, was discussed to contribute to PR3-ANCA associated ..
  10. Casslen B. Inhibitors of trypsin, chymotrypsin and elastase in human uterine fluid. Acta Obstet Gynecol Scand. 1986;65:121-4 pubmed
    ..and elastase was present in fractions containing alpha 2-macroglobulin, alpha 1-antitrypsin, alpha 1-antichymotrypsin and antileukoprotease...
  11. Pütter K, van Deenen N, Unland K, Prüfer D, Schulze Gronover C. Isoprenoid biosynthesis in dandelion latex is enhanced by the overexpression of three key enzymes involved in the mevalonate pathway. BMC Plant Biol. 2017;17:88 pubmed publisher
    ..ATP citrate lyase (ACL), which provides the acetyl-CoA utilized in the MVA pathway, and acetoacetyl-CoA thiolase (AACT), which catalyzes the first step in the pathway to produce acetoacetyl-CoA...
  12. Hee S, Willis A, Tudur Smith C, Day S, Miller F, Madan J, et al. Does the low prevalence affect the sample size of interventional clinical trials of rare diseases? An analysis of data from the aggregate analysis of clinicaltrials.gov. Orphanet J Rare Dis. 2017;12:44 pubmed publisher
    ..We downloaded all clinical trials from Aggregate Analysis of ClinialTrials.gov (AACT) and identified rare disease trials by cross-referencing MeSH terms in AACT with the list from Orphadata...
  13. Sweet R, Kamboh M, Wisniewski S, Lopez O, Klunk W, Kaufer D, et al. Apolipoprotein E and alpha-1-antichymotrypsin genotypes do not predict time to psychosis in Alzheimer's disease. J Geriatr Psychiatry Neurol. 2002;15:24-30 pubmed
    ..The objective of this study was to examine the effect of APOE4 and alpha1-antichymotrypsin/AA (ACT/AA) genotypes on time to psychosis onset in subjects with AD...
  14. Han Y, Yan C, Garner W. Proteolytic activation of matrix metalloproteinase-9 in skin wound healing is inhibited by alpha-1-antichymotrypsin. J Invest Dermatol. 2008;128:2334-42 pubmed publisher
    ..Then we determined that alpha-1-antichymotrypsin (alpha-ACT), an acute-phase factor abundantly present in the blister, effectively inhibited proMMP-9 ..
  15. Takayama T, McMullen B, Nelson P, Matsumura M, Fujikawa K. Characterization of hK4 (prostase), a prostate-specific serine protease: activation of the precursor of prostate specific antigen (pro-PSA) and single-chain urokinase-type plasminogen activator and degradation of prostatic acid phosphatase. Biochemistry. 2001;40:15341-8 pubmed
    ..These results indicate that hK4 may have a role in the physiologic processing of seminal plasma proteins such as pro-PSA, as well as in the pathogenesis of prostate cancer through its activation of pro-uPA. ..
  16. Dou C, Zhang J, Sun Y, Zhao X, Wu Q, Ji C, et al. The association of ACT -17 A/T polymorphism with Alzheimer's disease: a meta-analysis. Curr Alzheimer Res. 2013;10:63-71 pubmed
    Association studies between Alpha-1-antichymotrypsin (ACT)-17(A > T) polymorphisms and Alzheimer's disease (AD) susceptibility have shown conflicting results...
  17. Kamboh M, Minster R, Kenney M, Ozturk A, Desai P, Kammerer C, et al. Alpha-1-antichymotrypsin (ACT or SERPINA3) polymorphism may affect age-at-onset and disease duration of Alzheimer's disease. Neurobiol Aging. 2006;27:1435-9 pubmed
    ..Using AAO as a covariate, a linkage signal for AD has been detected on chromosome 14q32 near the alpha1-antichymotrypsin (ACT) gene...
  18. Witt H, Kage A, Luck W, Becker M. Alpha1-antitrypsin genotypes in patients with chronic pancreatitis. Scand J Gastroenterol. 2002;37:356-9 pubmed
    ..No significant differences were found between the allele frequency in patients and the control individuals (P > 0.1). Alpha1-antitrypsin deficiency is not related to the pathogenesis of idiopathic or hereditary CP. ..
  19. Fujimoto K, Ikeda S, Arai T, Tanaka N, Kumasaka T, Ishii T, et al. Polymorphism of SERPINE2 gene is associated with pulmonary emphysema in consecutive autopsy cases. BMC Med Genet. 2010;11:159 pubmed publisher
    ..30; p = 0.037) and the association was very prominent in smokers (OR = 2.02; 95% CI = 1.29-3.15; p = 0.002). SERPINE2 may be a risk factor for the development of emphysema and its association with emphysema may be stronger in smokers. ..
  20. Guan F, Gu J, Hu F, Zhu Y, Wang W. Association between α1-antichymotrypsin signal peptide -15A/T polymorphism and the risk of Alzheimer's disease: a meta-analysis. Mol Biol Rep. 2012;39:6661-9 pubmed publisher
    No consensus has been recently reached at the relationship between the α1-antichymotrypsin (ACT) signal peptide -15A/T polymorphism and Alzheimer’s disease (AD) risk...
  21. Park J, Masaki T, Mezaki Y, Yokoyama H, Nakamura M, Maehashi H, et al. Alpha-1 antichymotrypsin is involved in astrocyte injury in concert with arginine-vasopressin during the development of acute hepatic encephalopathy. PLoS ONE. 2017;12:e0189346 pubmed publisher
    ..However, many clinicians believe that there are any other factors involved in the development of HE. Therefore, the aim of this study was to identify novel HE-inducible factors, particularly those inducing astrocyte dysfunction...
  22. Porcellini E, Davis E, Chiappelli M, Ianni E, Di Stefano G, Forti P, et al. Elevated plasma levels of alpha-1-anti-chymotrypsin in age-related cognitive decline and Alzheimer's disease: a potential therapeutic target. Curr Pharm Des. 2008;14:2659-64 pubmed
    alpha-1-antichymotrypsin (ACT), is an acute phase protein and a protease inhibitor produced by the liver and brain...
  23. Mikolajczyk S, Millar L, Kumar A, Saedi M. Prostatic human kallikrein 2 inactivates and complexes with plasminogen activator inhibitor-1. Int J Cancer. 1999;81:438-42 pubmed
    ..hK2 comparably with protein C inhibitor (PCI) and at least 20 times more rapidly than alpha1-anti-chymotrypsin (ACT)...
  24. Dardiotis E, Hadjigeorgiou G, Dardioti M, Scarmeas N, Paterakis K, Aggelakis K, et al. Alpha-1 antichymotrypsin gene signal peptide a/t polymorphism and primary intracerebral hemorrhage. Eur Neurol. 2008;59:307-14 pubmed publisher
    Alpha-1 antichymotrypsin (ACT), a serine proteinase inhibitor, has been implicated in vascular pathology...
  25. Janciauskiene S, Wright H. Inflammation, antichymotrypsin, and lipid metabolism: autogenic etiology of Alzheimer's disease. Bioessays. 1998;20:1039-46 pubmed
    ..We hypothesize that specific interactions of A beta with the inflammatory serpin, alpha 1-antichymotrypsin, abolish the serpin proteinase inhibitor activity and stimulate formation of the neurotoxic fibrillar form of ..
  26. Brecher A, Yang M. Acetaldehyde inhibits chymotrypsin and serum anti-chymotrypsin activity. J Investig Med. 1998;46:146-52 pubmed
    ..clearly decreases the antichymotryptic activity of serum (consisting of alpha 1-proteinase inhibitor, alpha 1-antichymotrypsin, and alpha 2-macroglobulin)...
  27. Vanni S, Moda F, Zattoni M, Bistaffa E, De Cecco E, Rossi M, et al. Differential overexpression of SERPINA3 in human prion diseases. Sci Rep. 2017;7:15637 pubmed publisher
    ..Our data suggest that SERPINA3 may be involved in the pathogenesis and the progression of prion diseases, representing a valid tool for distinguishing different forms of these disorders in humans. ..
  28. Chelbi S, Wilson M, Veillard A, Ingles S, Zhang J, Mondon F, et al. Genetic and epigenetic mechanisms collaborate to control SERPINA3 expression and its association with placental diseases. Hum Mol Genet. 2012;21:1968-78 pubmed publisher
    SERPINA3 (Serpin peptidase inhibitor clade A member 3), also known as a1-antichymotrypsin, is a serine protease inhibitor involved in a wide range of biological processes...
  29. Chandra T, Stackhouse R, Kidd V, Robson K, Woo S. Sequence homology between human alpha 1-antichymotrypsin, alpha 1-antitrypsin, and antithrombin III. Biochemistry. 1983;22:5055-61 pubmed
    alpha 1-Antichymotrypsin mRNA was isolated by specific polysome immunoprecipitation from turpentine-treated baboon liver. The highly enriched mRNA was used for synthesis and cloning of the corresponding cDNA...
  30. Gopalan S, Wilczynska K, Konik B, Bryan L, Kordula T. Nuclear factor-1-X regulates astrocyte-specific expression of the alpha1-antichymotrypsin and glial fibrillary acidic protein genes. J Biol Chem. 2006;281:13126-33 pubmed
    ..1 allow a single gene encoding alpha1-antichymotrypsin (ACT) to be expressed in astrocytes and glioma cells...
  31. Licastro F, Chiapelli M, Caldarera C, Caruso C, Lio D, Corder E. Acute myocardial infarction and proinflammatory gene variants. Ann N Y Acad Sci. 2007;1119:227-42 pubmed
    ..This information may better define the pathogenesis of myocardial infarction and identify individuals who might benefit from early interventions. ..
  32. Lindmark B, Lilja H, Alm R, Eriksson S. The microheterogeneity of desialylated alpha 1-antichymotrypsin: the occurrence of two amino-terminal isoforms, one lacking a His-Pro dipeptide. Biochim Biophys Acta. 1989;997:90-5 pubmed
    ACT (alpha 1-antichymotrypsin), a serine antiproteinase with specificity against neutrophil cathepsin G, is homologous with alpha 1-antitrypsin, plasminogen activator inhibitor and angiotensinogen, all with known amino-terminal ..
  33. Licastro F, Chiappelli M, Grimaldi L, Morgan K, Kalsheker N, Calabrese E, et al. A new promoter polymorphism in the alpha-1-antichymotrypsin gene is a disease modifier of Alzheimer's disease. Neurobiol Aging. 2005;26:449-53 pubmed
    Increased levels of alpha-1-antichymotrypsin (ACT), a protease inhibitor and an acute phase protein, have been found in the brain and peripheral blood of patients with Alzheimer's disease (AD)...
  34. Dufour E, Desilets A, Longpre J, Leduc R. Stability of mutant serpin/furin complexes: dependence on pH and regulation at the deacylation step. Protein Sci. 2005;14:303-15 pubmed
    ..design more stable, potent, and specific serpin-based inhibitors, we constructed a series of AT and alpha(1)-antichymotrypsin (ACT) mutants by modifying the P(7)-P(1) region of their RSLs...
  35. Peck G, Smeeth L, Whittaker J, Casas J, Hingorani A, Sharma P. The genetics of primary haemorrhagic stroke, subarachnoid haemorrhage and ruptured intracranial aneurysms in adults. PLoS ONE. 2008;3:e3691 pubmed publisher
    ..Importantly, for several alleles previously found to be associated with protection from ischaemic stroke, there was a trend towards an increased risk of haemorrhagic stroke. ..
  36. Wang Y, Jiang H, Dai D, Su M, Martinka M, Brasher P, et al. Alpha 1 antichymotrypsin is aberrantly expressed during melanoma progression and predicts poor survival for patients with metastatic melanoma. Pigment Cell Melanoma Res. 2010;23:575-8 pubmed publisher
  37. Horvath A, Forsyth S, Coughlin P. Expression patterns of murine antichymotrypsin-like genes reflect evolutionary divergence at the Serpina3 locus. J Mol Evol. 2004;59:488-97 pubmed
    ..We have recently examined the murine serpin locus at 12F1 and observed that the single human alpha1-antichymotrypsin gene is represented by 14 paralogs...
  38. Yamamura J, Miyoshi Y, Tamaki Y, Taguchi T, Iwao K, Monden M, et al. mRNA expression level of estrogen-inducible gene, alpha 1-antichymotrypsin, is a predictor of early tumor recurrence in patients with invasive breast cancers. Cancer Sci. 2004;95:887-92 pubmed
    ..Of the 12 genes, mRNA expression levels of two [alpha 1-antichymotrypsin (ACT) and stanniocalcin 2 (STC2)] were significantly (P = 0.002 and P = 0...
  39. Chowanadisai W, Lonnerdal B. Alpha(1)-antitrypsin and antichymotrypsin in human milk: origin, concentrations, and stability. Am J Clin Nutr. 2002;76:828-33 pubmed
    The protease inhibitors alpha(1)-antitrypsin and antichymotrypsin are present in human milk, but little is known about their roles in protein digestion during infancy...
  40. Ki C, Na D, Kim H, Kim J. Alpha-1 antichymotrypsin and alpha-2 macroglobulin gene polymorphisms are not associated with Korean late-onset Alzheimer's disease. Neurosci Lett. 2001;302:69-72 pubmed
    ..Recently, several candidate genes such as alpha-1 antichymotrypsin (ACT) and alpha-2 macroglobulin (A2M) were reported to be associated with LOAD...
  41. Peltier J, Roperch J, Audebert S, Borg J, Camoin L. Quantitative proteomic analysis exploring progression of colorectal cancer: Modulation of the serpin family. J Proteomics. 2016;148:139-48 pubmed publisher
    ..The combination of these biomarkers should increase predictive powers of CRC diagnosis. The remaining candidates form a reserve for further evaluation of additional biomarkers for CRC diagnosis. ..
  42. Morii M, Travis J. Amino acid sequence at the reactive site of human alpha 1-antichymotrypsin. J Biol Chem. 1983;258:12749-52 pubmed
    The reactive site of human alpha 1-antichymotrypsin has been identified as encompassing a leucyl-seryl bond at the apparent P1 and P'1 positions...
  43. Hernández Charro B, Moreno S, Valiente A, Manubens J, Villar M, Ramos Arroyo M. [ACT/AA polymorphism could duplicate the APOE*epsilon4-associated Alzheimer's disease risk]. Med Clin (Barc). 2004;123:251-4 pubmed
    ..This study investigated the role of the a 1-antichymotrypsin (ACT) gene as a susceptibility factor for developing late-onset AD in the population of Navarra...
  44. Arpa A, Del Ser T, Goda G, Barba R, Bornstein B. Apolipoprotein E, angiotensin-converting enzyme and alpha-1-antichymotrypsin genotypes are not associated with post-stroke dementia. J Neurol Sci. 2003;210:77-82 pubmed
    ..E (including apoE coding and apoE promoter polymorphisms), angiotensin-converting enzyme (ACE) and alpha-1-antichymotrypsin (ACT). Thirty-two cases (21.3%) resulted in dementia 3 months after the stroke...
  45. Sun Y, Wright H, Janciauskiene S. Glioma cell activation by Alzheimer's peptide Abeta1-42, alpha1-antichymotrypsin, and their mixture. Cell Mol Life Sci. 2002;59:1734-43 pubmed
    We compared the effects ofAlzheimer's peptide (Abeta1-42), a,-antichymotrypsin (ACT) and an ACT/Abeta1-42 mixture on human glioma DK-MG cells...
  46. Pearce M, Cabrita L, Ellisdon A, Bottomley S. The loss of tryptophan 194 in antichymotrypsin lowers the kinetic barrier to misfolding. FEBS J. 2007;274:3622-3632 pubmed publisher
    b>Antichymotrypsin, a member of the serpin superfamily, has been shown to form inactive polymers in vivo, leading to chronic obstructive pulmonary disease...
  47. Ikari Y, Mulvihill E, Schwartz S. alpha 1-Proteinase inhibitor, alpha 1-antichymotrypsin, and alpha 2-macroglobulin are the antiapoptotic factors of vascular smooth muscle cells. J Biol Chem. 2001;276:11798-803 pubmed
    ..We show here that the plasma proteinase inhibitors alpha1-proteinase inhibitor, alpha1-antichymotrypsin, and alpha2-macroglobulin function as critical antiapoptotic factors for human vascular smooth muscle cells...
  48. Wang R, Kuo R, Yen S, Chu C, Wu Y, Huang Y, et al. Proteome demonstration of alpha-1-acid glycoprotein and alpha-1-antichymotrypsin candidate biomarkers for diagnosis of enterovirus 71 infection. Pediatr Infect Dis J. 2015;34:304-10 pubmed publisher
    ..Two proteins, alpha-1-acid-glycoprotein (AGP1) and alpha-antichymotrypsin (AACT), were not detected in the EV71-infected patients, but appeared in the control patient...
  49. Fleming S, Gibson A. Proteinase inhibitors in the kidney and its tumours. Histopathology. 1986;10:1303-13 pubmed
    The proteinase inhibitors alpha-1-antitrypsin and alpha-1-antichymotrypsin are found in a variety of tissues including the kidney...
  50. Wang M, Wang D, Zhang Q, Chai J, Peng Y, Cai X. Identification and cytochemical immunolocalization of acetyl-CoA acetyltransferase involved in the terpenoid mevalonate pathway in Euphorbia helioscopia laticifers. Bot Stud. 2017;58:62 pubmed publisher
    ..The acetyl-CoA acetyltransferase (AACT) is the initial enzyme in MVA pathway and is considered presently to be essential for terpenoid backbone ..
  51. Whitfield K, Yao X, Boomer K, Vogler G, Hayward M, Vandenbergh D. Analysis of candidate genes and hypertension in African American adults. Ethn Dis. 2009;19:18-22 pubmed
    ..AGT], Angiotensin I Converting Enzyme [ACE], Angiotensinogen II receptor, subtype 1 [AGTR1], and Alpha 1-Antichymotrypsin [ACT or SERPINA3]), in an African American sample...
  52. Llorca J, Rodriguez Rodriguez E, Dierssen Sotos T, Delgado Rodriguez M, Berciano J, Combarros O. Meta-analysis of genetic variability in the beta-amyloid production, aggregation and degradation metabolic pathways and the risk of Alzheimer's disease. Acta Neurol Scand. 2008;117:1-14 pubmed
    ..Additional meta-analyses of other different genes encoding for A beta production, aggregation and degradation mediators might help in determining the risk profile for AD. ..
  53. Crowther D, Serpell L, Dafforn T, Gooptu B, Lomas D. Nucleation of alpha 1-antichymotrypsin polymerization. Biochemistry. 2003;42:2355-63 pubmed
    Alpha(1)-antichymotrypsin is an acute phase plasma protein and a member of the serpin superfamily...
  54. Malerba G, Patuzzo C, Trabetti E, Lauciello M, Galavotti R, Pescollderungg L, et al. Chromosome 14 linkage analysis and mutation study of 2 serpin genes in allergic asthmatic families. J Allergy Clin Immunol. 2001;107:654-8 pubmed
    ..was done with 14 DNA markers and 4 polymorphisms in the genes encoding alpha(1)-anti-trypsin and alpha(1)-antichymotrypsin (ACT)...
  55. Tachikawa H, Tsuda M, Onoe K, Ueno M, Takagi S, Shinohara Y. alpha-1-Antichymotrypsin gene A1252G variant (ACT Isehara-1) is associated with a lacunar type of ischemic cerebrovascular disease. J Hum Genet. 2001;46:45-7 pubmed
    alpha-1-Antichymotrypsin (ACT) is a plasma protease inhibitor belonging to the serpine superfamily; it has many functions. and thus qualitative change in ACT is likely to result in specific diseases...
  56. Allgayer H, Babic R, Gruetzner K, Tarabichi A, Schildberg F, Heiss M. c-erbB-2 is of independent prognostic relevance in gastric cancer and is associated with the expression of tumor-associated protease systems. J Clin Oncol. 2000;18:2201-9 pubmed
    ..010), type-2 PAI (P =.021), cathepsin D (P =.036), matrix metalloproteinase-2 (P =. 024), alpha-1-antichymotrypsin (P =.025), and alpha-2-macroglobulin (P =.017)...
  57. Peter J, Unverzagt C, Hoesel W. Analysis of free prostate-specific antigen (PSA) after chemical release from the complex with alpha(1)-antichymotrypsin (PSA-ACT). Clin Chem. 2000;46:474-82 pubmed
    Prostate-specific antigen (PSA), a marker for prostate cancer (CaP), forms a covalent complex with alpha(1)-antichymotrypsin (ACT) in human blood...
  58. Duranton J, Adam C, Bieth J. Kinetic mechanism of the inhibition of cathepsin G by alpha 1-antichymotrypsin and alpha 1-proteinase inhibitor. Biochemistry. 1998;37:11239-45 pubmed
    ..Cat G is inhibited by alpha 1-antichymotrypsin (ACT) and alpha 1-proteinase inhibitor (alpha 1PI), two members of the serpin superfamily of proteins...
  59. Lukacs C, Rubin H, Christianson D. Engineering an anion-binding cavity in antichymotrypsin modulates the "spring-loaded" serpin-protease interaction. Biochemistry. 1998;37:3297-304 pubmed
    ..To probe the molecular basis of this conversion, we report the crystal structure of A349R antichymotrypsin in the reactive loop cleaved state at 2.1 A resolution...
  60. Baumann U, Huber R, Bode W, Grosse D, Lesjak M, Laurell C. Crystal structure of cleaved human alpha 1-antichymotrypsin at 2.7 A resolution and its comparison with other serpins. J Mol Biol. 1991;218:595-606 pubmed
    The crystal structure of proteolytically modified human alpha 1-antichymotrypsin (ACT), a member of the serpin superfamily, has been solved by Paterson search techniques and refined to an R-factor of 18.0% at 2...
  61. Hwang S, Steineckert B, Kohn A, Palkovits M, Hook V. Molecular studies define the primary structure of alpha1-antichymotrypsin (ACT) protease inhibitor in Alzheimer's disease brains. Comparison of act in hippocampus and liver. J Biol Chem. 1999;274:1821-7 pubmed
    An alpha1-antichymotrypsin-like serpin has been implicated in Alzheimer's disease (AD) based on immunochemical detection of alpha1-antichymotrypsin (ACT) in amyloid plaques from the hippocampus of AD brains...
  62. Poller W, Faber J, Scholz S, Weidinger S, Bartholome K, Olek K, et al. Mis-sense mutation of alpha 1-antichymotrypsin gene associated with chronic lung disease. Lancet. 1992;339:1538 pubmed