AIM-1

Summary

Gene Symbol: AIM-1
Description: aurora kinase B
Alias: AIK2, AIM-1, AIM1, ARK-2, ARK2, AurB, IPL1, PPP1R48, STK-1, STK12, STK5, aurkb-sv1, aurkb-sv2, aurora kinase B, aurora kinase B-Sv1, aurora kinase B-Sv2, aurora- and Ipl1-like midbody-associated protein 1, aurora-1, aurora-B, aurora-related kinase 2, aurora/IPL1-related kinase 2, protein phosphatase 1, regulatory subunit 48, serine/threonine kinase 12, serine/threonine-protein kinase 12, serine/threonine-protein kinase 5, serine/threonine-protein kinase aurora-B
Species: human
Products:     AIM-1

Top Publications

  1. Girdler F, Gascoigne K, Eyers P, Hartmuth S, Crafter C, Foote K, et al. Validating Aurora B as an anti-cancer drug target. J Cell Sci. 2006;119:3664-75 pubmed
    ..Using molecular genetic approaches, we show that inhibition of Aurora B kinase activity phenocopies ZM447439...
  2. Lucena Araujo A, de Oliveira F, Leite Cueva S, Dos Santos G, Falcao R, Rego E. High expression of AURKA and AURKB is associated with unfavorable cytogenetic abnormalities and high white blood cell count in patients with acute myeloid leukemia. Leuk Res. 2011;35:260-4 pubmed publisher
    ..001). In conclusion, we described a significant association between overexpression of AURKA/B and cytogenetics findings in AML, which may be relevant to new therapeutic approaches, based on Aurora kinase inhibitors. ..
  3. Gassmann R, Carvalho A, Henzing A, Ruchaud S, Hudson D, Honda R, et al. Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle. J Cell Biol. 2004;166:179-91 pubmed
    The chromosomal passenger complex of Aurora B kinase, INCENP, and Survivin has essential regulatory roles at centromeres and the central spindle in mitosis. Here, we describe Borealin, a novel member of the complex...
  4. Wu D, Asiedu M, Matsumura F, Wei Q. Phosphorylation of myosin II-interacting guanine nucleotide exchange factor (MyoGEF) at threonine 544 by aurora B kinase promotes the binding of polo-like kinase 1 to MyoGEF. J Biol Chem. 2014;289:7142-50 pubmed publisher
    ..In this study we report that aurora B-mediated phosphorylation of MyoGEF at Thr-544 creates a docking site for Plk1, leading to the localization and ..
  5. Steigemann P, Wurzenberger C, Schmitz M, Held M, Guizetti J, Maar S, et al. Aurora B-mediated abscission checkpoint protects against tetraploidization. Cell. 2009;136:473-84 pubmed publisher
    ..First, we found that Aurora B inactivation promotes completion of cytokinesis by abscission...
  6. Pouwels J, Kukkonen A, Lan W, Daum J, Gorbsky G, Stukenberg T, et al. Shugoshin 1 plays a central role in kinetochore assembly and is required for kinetochore targeting of Plk1. Cell Cycle. 2007;6:1579-85 pubmed
    ..Here we show that depletion or chemical inhibition of Aurora B kinase (AurB), the catalytic subunit of the CPC, disrupts accumulation of Sgo1 on the kinetochores in HeLa cells ..
  7. Honda R, Körner R, Nigg E. Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis. Mol Biol Cell. 2003;14:3325-41 pubmed
    The function of the Aurora B kinase at centromeres and the central spindle is crucial for chromosome segregation and cytokinesis, respectively...
  8. Liu D, Vader G, Vromans M, Lampson M, Lens S. Sensing chromosome bi-orientation by spatial separation of aurora B kinase from kinetochore substrates. Science. 2009;323:1350-3 pubmed publisher
    ..b>Aurora B kinase regulates chromosome-spindle attachments by phosphorylating kinetochore substrates that bind microtubules...
  9. Sharma A, Madhunapantula S, Gowda R, Berg A, Neves R, Robertson G. Identification of aurora kinase B and Wee1-like protein kinase as downstream targets of (V600E)B-RAF in melanoma. Am J Pathol. 2013;182:1151-62 pubmed publisher
    ..Involvement of aurora kinase B (AURKB) and Wee1-like protein kinase (WEE1) as downstream proteins in the (V600E)B-RAF pathway was validated ..
  10. Yang Y, Wu F, Ward T, Yan F, Wu Q, Wang Z, et al. Phosphorylation of HsMis13 by Aurora B kinase is essential for assembly of functional kinetochore. J Biol Chem. 2008;283:26726-36 pubmed publisher
    ..Here we show that phosphorylation of human HsMis13 by Aurora B kinase is required for functional kinetochore assembly in HeLa cells...

Detail Information

Publications62

  1. Girdler F, Gascoigne K, Eyers P, Hartmuth S, Crafter C, Foote K, et al. Validating Aurora B as an anti-cancer drug target. J Cell Sci. 2006;119:3664-75 pubmed
    ..Using molecular genetic approaches, we show that inhibition of Aurora B kinase activity phenocopies ZM447439...
  2. Lucena Araujo A, de Oliveira F, Leite Cueva S, Dos Santos G, Falcao R, Rego E. High expression of AURKA and AURKB is associated with unfavorable cytogenetic abnormalities and high white blood cell count in patients with acute myeloid leukemia. Leuk Res. 2011;35:260-4 pubmed publisher
    ..001). In conclusion, we described a significant association between overexpression of AURKA/B and cytogenetics findings in AML, which may be relevant to new therapeutic approaches, based on Aurora kinase inhibitors. ..
  3. Gassmann R, Carvalho A, Henzing A, Ruchaud S, Hudson D, Honda R, et al. Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle. J Cell Biol. 2004;166:179-91 pubmed
    The chromosomal passenger complex of Aurora B kinase, INCENP, and Survivin has essential regulatory roles at centromeres and the central spindle in mitosis. Here, we describe Borealin, a novel member of the complex...
  4. Wu D, Asiedu M, Matsumura F, Wei Q. Phosphorylation of myosin II-interacting guanine nucleotide exchange factor (MyoGEF) at threonine 544 by aurora B kinase promotes the binding of polo-like kinase 1 to MyoGEF. J Biol Chem. 2014;289:7142-50 pubmed publisher
    ..In this study we report that aurora B-mediated phosphorylation of MyoGEF at Thr-544 creates a docking site for Plk1, leading to the localization and ..
  5. Steigemann P, Wurzenberger C, Schmitz M, Held M, Guizetti J, Maar S, et al. Aurora B-mediated abscission checkpoint protects against tetraploidization. Cell. 2009;136:473-84 pubmed publisher
    ..First, we found that Aurora B inactivation promotes completion of cytokinesis by abscission...
  6. Pouwels J, Kukkonen A, Lan W, Daum J, Gorbsky G, Stukenberg T, et al. Shugoshin 1 plays a central role in kinetochore assembly and is required for kinetochore targeting of Plk1. Cell Cycle. 2007;6:1579-85 pubmed
    ..Here we show that depletion or chemical inhibition of Aurora B kinase (AurB), the catalytic subunit of the CPC, disrupts accumulation of Sgo1 on the kinetochores in HeLa cells ..
  7. Honda R, Körner R, Nigg E. Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis. Mol Biol Cell. 2003;14:3325-41 pubmed
    The function of the Aurora B kinase at centromeres and the central spindle is crucial for chromosome segregation and cytokinesis, respectively...
  8. Liu D, Vader G, Vromans M, Lampson M, Lens S. Sensing chromosome bi-orientation by spatial separation of aurora B kinase from kinetochore substrates. Science. 2009;323:1350-3 pubmed publisher
    ..b>Aurora B kinase regulates chromosome-spindle attachments by phosphorylating kinetochore substrates that bind microtubules...
  9. Sharma A, Madhunapantula S, Gowda R, Berg A, Neves R, Robertson G. Identification of aurora kinase B and Wee1-like protein kinase as downstream targets of (V600E)B-RAF in melanoma. Am J Pathol. 2013;182:1151-62 pubmed publisher
    ..Involvement of aurora kinase B (AURKB) and Wee1-like protein kinase (WEE1) as downstream proteins in the (V600E)B-RAF pathway was validated ..
  10. Yang Y, Wu F, Ward T, Yan F, Wu Q, Wang Z, et al. Phosphorylation of HsMis13 by Aurora B kinase is essential for assembly of functional kinetochore. J Biol Chem. 2008;283:26726-36 pubmed publisher
    ..Here we show that phosphorylation of human HsMis13 by Aurora B kinase is required for functional kinetochore assembly in HeLa cells...
  11. Knauer S, Bier C, Habtemichael N, Stauber R. The Survivin-Crm1 interaction is essential for chromosomal passenger complex localization and function. EMBO Rep. 2006;7:1259-65 pubmed
    ..By contrast, CPC assembly does not seem to require the Survivin-Crm1 interaction. Our report shows the functional significance of the Survivin-Crm1 interface and provides a novel link between the mitotic effector Crm1 and the CPC. ..
  12. Song S, Kim S, Song M, Lim D. Aurora B-mediated phosphorylation of RASSF1A maintains proper cytokinesis by recruiting Syntaxin16 to the midzone and midbody. Cancer Res. 2009;69:8540-4 pubmed publisher
    b>Aurora B is critically involved in ensuring proper cytokinesis and maintaining genomic stability...
  13. Sugiyama K, Sugiura K, Hara T, Sugimoto K, Shima H, Honda K, et al. Aurora-B associated protein phosphatases as negative regulators of kinase activation. Oncogene. 2002;21:3103-11 pubmed
    ..We found that this enzyme is an arginine-directed kinase that can phosphorylate histone H3 at serines 10 and 28 in vitro, suggesting that human Aurora-B is a mitotic histone H3 kinase. ..
  14. Joo H, Zhai L, Yang C, Nie S, Erdjument Bromage H, Tempst P, et al. Regulation of cell cycle progression and gene expression by H2A deubiquitination. Nature. 2007;449:1068-72 pubmed
    ..This study identifies the major deubiquitinase for histone H2A and demonstrates that H2A deubiquitination is critically involved in cell cycle progression and gene expression. ..
  15. Chen H, Tang C, Chen C, Tang T. Overexpression of an Aurora-C kinase-deficient mutant disrupts the Aurora-B/INCENP complex and induces polyploidy. J Biomed Sci. 2005;12:297-310 pubmed
    ..Together, our results showed that Aurora-C is a chromosomal passenger protein, which may serve as a key regulator in cell division. ..
  16. Ozlu N, Monigatti F, Renard B, Field C, Steen H, Mitchison T, et al. Binding partner switching on microtubules and aurora-B in the mitosis to cytokinesis transition. Mol Cell Proteomics. 2010;9:336-50 pubmed publisher
    ..Concretely, we report a central role for Aurora-B in regulating the C phase cytoskeleton. ..
  17. Sun L, Gao J, Dong X, Liu M, Li D, Shi X, et al. EB1 promotes Aurora-B kinase activity through blocking its inactivation by protein phosphatase 2A. Proc Natl Acad Sci U S A. 2008;105:7153-8 pubmed publisher
    ..These findings establish Aurora-B as an EB1-interacting protein and suggest that EB1 stimulates Aurora-B activity through antagonizing its dephosphorylation/inactivation by PP2A. ..
  18. Gully C, Velazquez Torres G, Shin J, Fuentes Mattei E, Wang E, Carlock C, et al. Aurora B kinase phosphorylates and instigates degradation of p53. Proc Natl Acad Sci U S A. 2012;109:E1513-22 pubmed publisher
    b>Aurora B is a mitotic checkpoint kinase that plays a pivotal role in the cell cycle, ensuring correct chromosome segregation and normal progression through mitosis...
  19. Gruneberg U, Neef R, Honda R, Nigg E, Barr F. Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2. J Cell Biol. 2004;166:167-72 pubmed
    ..of MKlp1 and MKlp2, two vertebrate mitotic kinesins essential for cytokinesis, in the spatial regulation of the Aurora B kinase...
  20. Yasui Y, Urano T, Kawajiri A, Nagata K, Tatsuka M, Saya H, et al. Autophosphorylation of a newly identified site of Aurora-B is indispensable for cytokinesis. J Biol Chem. 2004;279:12997-3003 pubmed
    ..These results indicate that the phosphorylation of Thr-232 is an essential regulatory mechanism for Aurora-B activation. ..
  21. Chen Y, Chen C, Twu N, Yen M, Lai C, Wu H, et al. Overexpression of Aurora B is associated with poor prognosis in epithelial ovarian cancer patients. Virchows Arch. 2009;455:431-40 pubmed publisher
    Recent studies have indicated that Aurora B expression is related to cell proliferation and prognosis in many cancers, but its association with epithelial ovarian carcinoma is not fully understood...
  22. Ban R, Matsuzaki H, Akashi T, Sakashita G, Taniguchi H, Park S, et al. Mitotic regulation of the stability of microtubule plus-end tracking protein EB3 by ubiquitin ligase SIAH-1 and Aurora mitotic kinases. J Biol Chem. 2009;284:28367-81 pubmed publisher
    ..Our results provide new insight into a regulatory mechanism of +TIPs in cell cycle transition. ..
  23. Sampath S, Ohi R, Leismann O, Salic A, Pozniakovski A, Funabiki H. The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly. Cell. 2004;118:187-202 pubmed publisher
    ..B, two new components of the vertebrate chromosomal passenger complex containing Incenp, Survivin, and the kinase Aurora B, and demonstrate that this complex is required for chromatin-induced microtubule stabilization and spindle ..
  24. Guo J, Anderson M, Tapang P, Palma J, Rodriguez L, Niquette A, et al. Identification of genes that confer tumor cell resistance to the aurora B kinase inhibitor, AZD1152. Pharmacogenomics J. 2009;9:90-102 pubmed publisher
    AZD1152 is a highly selective Aurora B kinase inhibitor currently undergoing Phase I and II clinical evaluation in patients with acute myelogenous leukemia and advanced solid malignancies...
  25. Lampson M, Renduchitala K, Khodjakov A, Kapoor T. Correcting improper chromosome-spindle attachments during cell division. Nat Cell Biol. 2004;6:232-7 pubmed
    ..Our results provide direct evidence for a mechanism required for the maintenance of genome integrity during cell division. ..
  26. Wheatley S, Barrett R, Andrews P, Medema R, Morley S, Swedlow J, et al. Phosphorylation by aurora-B negatively regulates survivin function during mitosis. Cell Cycle. 2007;6:1220-30 pubmed
    Survivin operates in a complex with aurora B kinase and is phosphorylated by it on threonine 117 in vitro. Here we ask whether phosphorylation of survivin by aurora B kinase regulates its function during mitosis in vivo...
  27. Takeshita M, Koga T, Takayama K, Ijichi K, Yano T, Maehara Y, et al. Aurora-B overexpression is correlated with aneuploidy and poor prognosis in non-small cell lung cancer. Lung Cancer. 2013;80:85-90 pubmed publisher
    ..Thus, Aurora-B may serve as a new therapeutic target in against patients with NSCLC, although further studies will be necessary...
  28. Vázquez Novelle M, Petronczki M. Relocation of the chromosomal passenger complex prevents mitotic checkpoint engagement at anaphase. Curr Biol. 2010;20:1402-7 pubmed publisher
    ..prevents mitotic checkpoint reactivation when sister centromeres are split and tension is lost at anaphase onset? Aurora B kinase, the catalytic subunit of the chromosomal passenger protein complex (CPC) [7], acts as a sensor at inner ..
  29. Wang E, Ballister E, Lampson M. Aurora B dynamics at centromeres create a diffusion-based phosphorylation gradient. J Cell Biol. 2011;194:539-49 pubmed publisher
    b>Aurora B kinase is essential for successful cell division and regulates spindle assembly and kinetochore-microtubule interactions...
  30. Welburn J, Vleugel M, Liu D, Yates J, Lampson M, Fukagawa T, et al. Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface. Mol Cell. 2010;38:383-92 pubmed publisher
    ..Here we demonstrate that Aurora B kinase phosphorylates three spatially distinct targets within the conserved outer kinetochore KNL1/Mis12 complex/..
  31. Lipp J, Hirota T, Poser I, Peters J. Aurora B controls the association of condensin I but not condensin II with mitotic chromosomes. J Cell Sci. 2007;120:1245-55 pubmed
    ..Here we show that the mitotic kinase Aurora B regulates the association of condensin I, but not the interaction of condensin II with chromatin...
  32. Fuller B, Lampson M, Foley E, Rosasco Nitcher S, Le K, Tobelmann P, et al. Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient. Nature. 2008;453:1132-6 pubmed publisher
    ..Here we examine the anaphase dynamics of protein phosphorylation by aurora B kinase, a key mitotic regulator, using fluorescence resonance energy transfer (FRET)-based sensors in living HeLa ..
  33. Morozova O, Vojvodic M, Grinshtein N, Hansford L, Blakely K, Maslova A, et al. System-level analysis of neuroblastoma tumor-initiating cells implicates AURKB as a novel drug target for neuroblastoma. Clin Cancer Res. 2010;16:4572-82 pubmed publisher
    ..study revealed that genes in the BRCA1 signaling pathway are frequently misexpressed in NB TICs and implicated Aurora B kinase as a potential drug target for NB therapy...
  34. Saurin A, van der Waal M, Medema R, Lens S, Kops G. Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis. Nat Commun. 2011;2:316 pubmed publisher
    The mitotic checkpoint prevents mitotic exit until all chromosomes are attached to spindle microtubules. Aurora B kinase indirectly invokes this checkpoint by destabilizing incorrect attachments; however, a more direct role remains ..
  35. Borges K, Moreno D, Martinelli C, Antonini S, de Castro M, Tucci S, et al. Spindle assembly checkpoint gene expression in childhood adrenocortical tumors (ACT): Overexpression of Aurora kinases A and B is associated with a poor prognosis. Pediatr Blood Cancer. 2013;60:1809-16 pubmed publisher
    ..R337H mutation. Our results suggest that AURKA and AURKB overexpression in pediatric ACT may be related to more aggressive disease and the inhibition of these proteins could be an interesting approach for the treatment of these tumors. ..
  36. Wheatley S, Carvalho A, Vagnarelli P, Earnshaw W. INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis. Curr Biol. 2001;11:886-90 pubmed
    ..Our data provide the first biochemical evidence that Survivin can interact directly with members of the chromosomal passenger complex. ..
  37. Tsukahara T, Tanno Y, Watanabe Y. Phosphorylation of the CPC by Cdk1 promotes chromosome bi-orientation. Nature. 2010;467:719-23 pubmed publisher
    ..chromosome bi-orientation at prometaphase, the chromosomal passenger complex (CPC), composed of catalytic kinase Aurora B and regulatory components (INCENP, Survivin and Borealin), must be localized to centromeres to phosphorylate ..
  38. Mendiola M, Barriuso J, Mariño Enríquez A, Redondo A, Domínguez Cáceres A, Hernández Cortés G, et al. Aurora kinases as prognostic biomarkers in ovarian carcinoma. Hum Pathol. 2009;40:631-8 pubmed publisher
    ..03) and overall survival (P = .02). In conclusion, Aurora A expression seems to have a prognostic value in ovarian carcinoma. ..
  39. Morrow C, Tighe A, Johnson V, Scott M, Ditchfield C, Taylor S. Bub1 and aurora B cooperate to maintain BubR1-mediated inhibition of APC/CCdc20. J Cell Sci. 2005;118:3639-52 pubmed
    ..However, in human somatic cells Bub1 and aurora B kinase activity do not appear to be essential for spindle checkpoint function...
  40. Beardmore V, Ahonen L, Gorbsky G, Kallio M. Survivin dynamics increases at centromeres during G2/M phase transition and is regulated by microtubule-attachment and Aurora B kinase activity. J Cell Sci. 2004;117:4033-42 pubmed
    ..Survivin physically associates with Aurora B, a serine-threonine kinase involved in microtubule attachment to centromeres and regulation of chromosome ..
  41. Tien A, Lin M, Su L, Hong Y, Cheng T, Lee Y, et al. Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model. Mol Cell Proteomics. 2004;3:93-104 pubmed
    ..Together, these results justify the timely implementation of in silico biology in routine wet-lab studies and have also allowed the application of a new approach to the elucidation of protein function in the post-genomic era. ..
  42. Kawajiri A, Yasui Y, Goto H, Tatsuka M, Takahashi M, Nagata K, et al. Functional significance of the specific sites phosphorylated in desmin at cleavage furrow: Aurora-B may phosphorylate and regulate type III intermediate filaments during cytokinesis coordinatedly with Rho-kinase. Mol Biol Cell. 2003;14:1489-500 pubmed
    ..The results presented here suggest the possibility that Aurora-B may regulate cleavage furrow-specific phosphorylation and segregation of type III IFs coordinatedly with Rho-kinase during cytokinesis. ..
  43. Sakita Suto S, Kanda A, Suzuki F, Sato S, Takata T, Tatsuka M. Aurora-B regulates RNA methyltransferase NSUN2. Mol Biol Cell. 2007;18:1107-17 pubmed
    ..These results indicate that Aurora-B participates to regulate the assembly of nucleolar RNA-processing machinery and the RNA methyltransferase activity of NSUN2 via phosphorylation at Ser139 during mitosis. ..
  44. Hirota T, Lipp J, Toh B, Peters J. Histone H3 serine 10 phosphorylation by Aurora B causes HP1 dissociation from heterochromatin. Nature. 2005;438:1176-80 pubmed
    ..During mitosis, H3 is also phosphorylated by the kinase Aurora B. Although H3 phosphorylation is a hallmark of mitosis, its function remains mysterious...
  45. Chen J, Jin S, Tahir S, Zhang H, Liu X, Sarthy A, et al. Survivin enhances Aurora-B kinase activity and localizes Aurora-B in human cells. J Biol Chem. 2003;278:486-90 pubmed
    ..These results indicate that survivin stimulates Aurora-B kinase activity and helps correctly target Aurora-B to its substrates during the cell cycle, thus providing a mechanism as to how survivin exerts its function in human cells. ..
  46. Sumara I, Quadroni M, Frei C, Olma M, Sumara G, Ricci R, et al. A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells. Dev Cell. 2007;12:887-900 pubmed
    ..b>Aurora B directly binds to the substrate-recognition domain of KLHL9 and KLHL13 in vitro, and coimmunoprecipitates with ..
  47. Tanenbaum M, Macurek L, van der Vaart B, Galli M, Akhmanova A, Medema R. A complex of Kif18b and MCAK promotes microtubule depolymerization and is negatively regulated by Aurora kinases. Curr Biol. 2011;21:1356-65 pubmed publisher
    ..Together, these results uncover a novel role for Aurora kinases in regulating spindle MT dynamics through Kif18b-MCAK and suggest that the Kif18b-MCAK complex constitutes the major MT plus-end depolymerizing activity in mitotic cells. ..
  48. Perrera C, Colombo R, Valsasina B, Carpinelli P, Troiani S, Modugno M, et al. Identification of Myb-binding protein 1A (MYBBP1A) as a novel substrate for aurora B kinase. J Biol Chem. 2010;285:11775-85 pubmed publisher
    ..Using biochemical, mass spectrometric, and cellular approaches, we identified MYBBP1A as a novel Aurora B substrate and serine 1303 as the major phosphorylation site...
  49. Ryser S, Dizin E, Jefford C, Delaval B, Gagos S, Christodoulidou A, et al. Distinct roles of BARD1 isoforms in mitosis: full-length BARD1 mediates Aurora B degradation, cancer-associated BARD1beta scaffolds Aurora B and BRCA2. Cancer Res. 2009;69:1125-34 pubmed publisher
    ..BARD1, but not BRCA1, localizes to the midbody at telophase and cytokinesis, where it colocalizes with Aurora B. The 97-kDa full-length (FL) BARD1 coimmunoprecipates with BRCA1, but the 82-kDa BARD1beta coimmunoprecipitates ..
  50. Shindo M, Nakano H, Kuroyanagi H, Shirasawa T, Mihara M, Gilbert D, et al. cDNA cloning, expression, subcellular localization, and chromosomal assignment of mammalian aurora homologues, aurora-related kinase (ARK) 1 and 2. Biochem Biophys Res Commun. 1998;244:285-92 pubmed
    ..Here we have identified mammalian aurora homologues, designated aurora-related kinase (ARK) 1 and ARK2. Kinase domains of murine ARK1 and ARK2 showed 61 and 62% identity, respectively, to that of aurora at the amino ..
  51. Tatsuka M, Katayama H, Ota T, Tanaka T, Odashima S, Suzuki F, et al. Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells. Cancer Res. 1998;58:4811-6 pubmed
    Aurora- and Ipl1-like midbody-associated protein (AIM-1) is a serine/ threonine kinase that is structurally related to Drosophila aurora and Saccharomyces cerevisiae Ipl1, both of which are required for chromosome segregation...
  52. Nozawa R, Nagao K, Masuda H, Iwasaki O, Hirota T, Nozaki N, et al. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. Nat Cell Biol. 2010;12:719-27 pubmed publisher
    ..Furthermore, POGZ is required for the correct activation and dissociation of Aurora B kinase from chromosome arms during M phase...
  53. Douglas M, Davies T, Joseph N, Mishima M. Aurora B and 14-3-3 coordinately regulate clustering of centralspindlin during cytokinesis. Curr Biol. 2010;20:927-33 pubmed publisher
    ..Stable accumulation of centralspindlin at the spindle midzone requires its multimerization into clusters and Aurora B kinase activity, which peaks at the central spindle during anaphase...
  54. Vader G, Kauw J, Medema R, Lens S. Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody. EMBO Rep. 2006;7:85-92 pubmed
    ..Thus, Survivin is an important mediator of centromere and midbody docking of Aurora-B during mitosis. ..
  55. Yang C, Tang X, Guo X, Niikura Y, Kitagawa K, Cui K, et al. Aurora-B mediated ATM serine 1403 phosphorylation is required for mitotic ATM activation and the spindle checkpoint. Mol Cell. 2011;44:597-608 pubmed publisher
    ..ATM-mediated Bub1 Ser314 phosphorylation is required for Bub1 activity and is essential for the activation of the spindle checkpoint. Collectively, our data highlight mechanisms of a critical function of ATM in mitosis. ..
  56. Ikezoe T, Takeuchi T, Yang J, Adachi Y, Nishioka C, Furihata M, et al. Analysis of Aurora B kinase in non-Hodgkin lymphoma. Lab Invest. 2009;89:1364-73 pubmed publisher
    This study explored the levels of Aurora B, a key regulator of mitosis, in 71 lymph nodes and tumor specimens excised operatively from individuals with various types of non-Hodgkin lymphoma (NHLs)...
  57. Jeyaprakash A, Klein U, Lindner D, Ebert J, Nigg E, Conti E. Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together. Cell. 2007;131:271-85 pubmed
    ..three components of the CPC that regulate the activity and localization of its enzymatic component, the kinase Aurora B. We determined the 1...
  58. Kawashima S, Tsukahara T, Langegger M, Hauf S, Kitajima T, Watanabe Y. Shugoshin enables tension-generating attachment of kinetochores by loading Aurora to centromeres. Genes Dev. 2007;21:420-35 pubmed
    ..We propose that ensuring bipolar attachment of kinetochores is the primary role of shugoshin and the role of cohesion protection might have codeveloped to facilitate this process. ..
  59. Banerjee B, Kestner C, Stukenberg P. EB1 enables spindle microtubules to regulate centromeric recruitment of Aurora B. J Cell Biol. 2014;204:947-63 pubmed publisher
    The Aurora B kinase coordinates kinetochore-microtubule attachments with spindle checkpoint signaling on each mitotic chromosome...
  60. Wu L, Ma C, Zhao Y, Jain A. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression. J Biol Chem. 2011;286:2236-44 pubmed publisher
    ..Using a proteomic approach, we have identified the Aurora kinase B as a novel binding partner of NIR...
  61. Schmidt J, Kiyomitsu T, Hori T, Backer C, Fukagawa T, Cheeseman I. Aurora B kinase controls the targeting of the Astrin-SKAP complex to bioriented kinetochores. J Cell Biol. 2010;191:269-80 pubmed publisher
    ..Although most dynein-associated proteins localize to unaligned kinetochores in an Aurora B-dependent manner, Astrin, SKAP, and LC8 localization is antagonized by Aurora B such that they target exclusively ..
  62. Sasai K, Katayama H, Stenoien D, Fujii S, Honda R, Kimura M, et al. Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells. Cell Motil Cytoskeleton. 2004;59:249-63 pubmed
    ..Finally, Aurora-C could rescue the Aurora-B silenced multinucleation phenotype, demonstrating that Aurora-C kinase function overlaps with and complements Aurora-B kinase function in mitosis. ..