AIM-1

Summary

Gene Symbol: AIM-1
Description: aurora kinase B
Alias: AIK2, AIM-1, AIM1, ARK-2, ARK2, AurB, IPL1, PPP1R48, STK-1, STK12, STK5, aurkb-sv1, aurkb-sv2, aurora kinase B, aurora kinase B-Sv1, aurora kinase B-Sv2, aurora- and Ipl1-like midbody-associated protein 1, aurora-1, aurora-B, aurora-related kinase 2, aurora/IPL1-related kinase 2, protein phosphatase 1, regulatory subunit 48, serine/threonine kinase 12, serine/threonine-protein kinase 12, serine/threonine-protein kinase 5, serine/threonine-protein kinase aurora-B
Species: human
Products:     AIM-1

Top Publications

  1. Zeitlin S, Shelby R, Sullivan K. CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis. J Cell Biol. 2001;155:1147-57 pubmed
    b>Aurora B is a mitotic protein kinase that phosphorylates histone H3, behaves as a chromosomal passenger protein, and functions in cytokinesis...
  2. Sagulenko E, Savelyeva L, Ehemann V, Sagulenko V, Hofmann W, Arnold K, et al. Suppression of polyploidy by the BRCA2 protein. Cancer Lett. 2007;257:65-72 pubmed
    ..Compared with MX-1, the ectopically BRCA2-expressing cells had different intracellular levels of Aurora A, Aurora B, p21, E2F-1, and pRb, suggesting a BRCA2-mediated suppression of polyploidy via stabilization of the checkpoint ..
  3. Nair J, Ho A, Tse A, Coward J, Cheema H, Ambrosini G, et al. Aurora B kinase regulates the postmitotic endoreduplication checkpoint via phosphorylation of the retinoblastoma protein at serine 780. Mol Biol Cell. 2009;20:2218-28 pubmed publisher
    The phenotypic change characteristic of Aurora B inhibition is the induction of polyploidy...
  4. Salimian K, Ballister E, Smoak E, Wood S, Panchenko T, Lampson M, et al. Feedback control in sensing chromosome biorientation by the Aurora B kinase. Curr Biol. 2011;21:1158-65 pubmed publisher
    ..This process relies largely on increased phosphorylation of kinetochore substrates of Aurora B kinase at misaligned versus aligned kinetochores...
  5. Kiyomitsu T, Iwasaki O, Obuse C, Yanagida M. Inner centromere formation requires hMis14, a trident kinetochore protein that specifically recruits HP1 to human chromosomes. J Cell Biol. 2010;188:791-807 pubmed publisher
    ..interaction with HP1 disrupt the inner centromere, characterized by the absence of hSgo1 (Shugoshin-like 1) and aurora B. The assembly of HP1 in the inner centromere and the localization of hMis14 at the kinetochore are mutually ..
  6. Lin Y, Su L, Yu C, Wong F, Yeh H, Chen S, et al. Gene expression profiles of the aurora family kinases. Gene Expr. 2006;13:15-26 pubmed
  7. Wang F, Ulyanova N, van der Waal M, Patnaik D, Lens S, Higgins J. A positive feedback loop involving Haspin and Aurora B promotes CPC accumulation at centromeres in mitosis. Curr Biol. 2011;21:1061-9 pubmed publisher
    ..In addition, CPC binding to shugoshin proteins contributes to centromeric Aurora B localization [5, 6]...
  8. Tanenbaum M, Medema R. Localized Aurora B activity spatially controls non-kinetochore microtubules during spindle assembly. Chromosoma. 2011;120:599-607 pubmed publisher
    ..In addition to the small GTPase Ran, there is evidence that Aurora B kinase might also generate a spatial cue around chromosomes but direct proof for this is still lacking...
  9. Crosio C, Fimia G, Loury R, Kimura M, Okano Y, Zhou H, et al. Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases. Mol Cell Biol. 2002;22:874-85 pubmed
    ..Since Aurora-A and Aurora-B are known to be overexpressed in a variety of human cancers, our findings provide an attractive link between cell transformation, chromatin modifications and a specific kinase system. ..

More Information

Publications93

  1. Nigg E. Mitotic kinases as regulators of cell division and its checkpoints. Nat Rev Mol Cell Biol. 2001;2:21-32 pubmed
    ..Here, I give an overview of the many mitotic kinases that regulate cell division and the fidelity of chromosome transmission. ..
  2. Minoshima Y, Kawashima T, Hirose K, Tonozuka Y, Kawajiri A, Bao Y, et al. Phosphorylation by aurora B converts MgcRacGAP to a RhoGAP during cytokinesis. Dev Cell. 2003;4:549-60 pubmed
    ..Among these, Aurora B, RhoA, and the GAP MgcRacGAP have been implicated in cytokinesis, but their underlying mechanisms of action have ..
  3. Carlton J, Caballe A, Agromayor M, Kloc M, Martin Serrano J. ESCRT-III governs the Aurora B-mediated abscission checkpoint through CHMP4C. Science. 2012;336:220-5 pubmed publisher
    ..Accordingly, CHMP4C functioned in the Aurora B-dependent abscission checkpoint to prevent both premature resolution of intercellular chromosome bridges and ..
  4. Wang W, Stukenberg P, Brautigan D. Phosphatase inhibitor-2 balances protein phosphatase 1 and aurora B kinase for chromosome segregation and cytokinesis in human retinal epithelial cells. Mol Biol Cell. 2008;19:4852-62 pubmed publisher
    ..Inhibition of Aurora B by hesperadin produced multinucleated cells and reduced H3S10 phosphorylation...
  5. Klein U, Nigg E, Gruneberg U. Centromere targeting of the chromosomal passenger complex requires a ternary subcomplex of Borealin, Survivin, and the N-terminal domain of INCENP. Mol Biol Cell. 2006;17:2547-58 pubmed
    The chromosomal passenger complex (CPC), consisting of the serine/threonine kinase Aurora B, the inner centromere protein INCENP, Survivin, and Borealin/DasraB, has essential functions at the centromere in ensuring correct chromosome ..
  6. Yamagishi Y, Honda T, Tanno Y, Watanabe Y. Two histone marks establish the inner centromere and chromosome bi-orientation. Science. 2010;330:239-43 pubmed publisher
    For proper partitioning of chromosomes in mitosis, the chromosomal passenger complex (CPC) including Aurora B and survivin must be localized at the center of paired kinetochores, at the site called the inner centromere...
  7. Yüce O, Piekny A, Glotzer M. An ECT2-centralspindlin complex regulates the localization and function of RhoA. J Cell Biol. 2005;170:571-82 pubmed
    ..Thus, central spindle localization of ECT2 assists division plane positioning and the CYK-4 subunit of centralspindlin acts upstream of RhoA to promote furrow assembly. ..
  8. Liu D, Vleugel M, Backer C, Hori T, Fukagawa T, Cheeseman I, et al. Regulated targeting of protein phosphatase 1 to the outer kinetochore by KNL1 opposes Aurora B kinase. J Cell Biol. 2010;188:809-20 pubmed publisher
    ..The Aurora B kinase phosphorylates kinetochore substrates to destabilize kinetochore-microtubule interactions and eliminate ..
  9. Teng C, Hsieh Y, Phan L, Shin J, Gully C, Velazquez Torres G, et al. FBXW7 is involved in Aurora B degradation. Cell Cycle. 2012;11:4059-68 pubmed publisher
    ..b>Aurora B is a mitotic checkpoint kinase that plays a pivotal role in mitosis by ensuring correct chromosome segregation ..
  10. Scrittori L, Skoufias D, Hans F, Gerson V, Sassone Corsi P, Dimitrov S, et al. A small C-terminal sequence of Aurora B is responsible for localization and function. Mol Biol Cell. 2005;16:292-305 pubmed
    b>Aurora B, a protein kinase required in mitosis, localizes to inner centromeres at metaphase and the spindle midzone in anaphase and is required for proper chromosome segregation and cytokinesis...
  11. Sorrentino R, Libertini S, Pallante P, Troncone G, Palombini L, Bavetsias V, et al. Aurora B overexpression associates with the thyroid carcinoma undifferentiated phenotype and is required for thyroid carcinoma cell proliferation. J Clin Endocrinol Metab. 2005;90:928-35 pubmed
    ..b>Aurora B mediates chromosome segregation by ensuring orientation of sister chromatids and overexpression of Aurora B in ..
  12. Jelluma N, Brenkman A, van den Broek N, Cruijsen C, van Osch M, Lens S, et al. Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment. Cell. 2008;132:233-46 pubmed publisher
    ..We report that Borealin/DasraB, a member of the complex that regulates the Aurora B kinase, is directly phosphorylated by Mps1 on residues that are crucial for Aurora B activity and chromosome ..
  13. Kaitna S, Mendoza M, Jantsch Plunger V, Glotzer M. Incenp and an aurora-like kinase form a complex essential for chromosome segregation and efficient completion of cytokinesis. Curr Biol. 2000;10:1172-81 pubmed
    ..We propose that this complex acts by promoting dissolution of sister chromatid cohesion and the assembly of the central spindle. ..
  14. Xu Z, Ogawa H, Vagnarelli P, Bergmann J, Hudson D, Ruchaud S, et al. INCENP-aurora B interactions modulate kinase activity and chromosome passenger complex localization. J Cell Biol. 2009;187:637-53 pubmed publisher
    ..In this study, we investigate how interactions between the INCENP C terminus and aurora B set the level of kinase activity...
  15. Yang H, Burke T, Dempsey J, Diaz B, Collins E, Toth J, et al. Mitotic requirement for aurora A kinase is bypassed in the absence of aurora B kinase. FEBS Lett. 2005;579:3385-91 pubmed
    ..treatment of cells with dual aurora A and B kinase inhibitors produces phenotypes identical to inactivation of aurora B. We found that dual aurora kinase inhibitors in fact potently inhibit cellular activities of both kinases, ..
  16. Chu Y, Yao P, Wang W, Wang D, Wang Z, Zhang L, et al. Aurora B kinase activation requires survivin priming phosphorylation by PLK1. J Mol Cell Biol. 2011;3:260-7 pubmed publisher
    ..Accurate attachment of spindle microtubules to kinetochore requires the chromosomal passenger of Aurora B kinase complex with borealin, INCENP and survivin (SUR)...
  17. Wang F, Dai J, Daum J, Niedzialkowska E, Banerjee B, Stukenberg P, et al. Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis. Science. 2010;330:231-5 pubmed publisher
    b>Aurora B is a component of the chromosomal passenger complex (CPC) required for correct spindle-kinetochore attachments during chromosome segregation and for cytokinesis...
  18. Petsalaki E, Akoumianaki T, Black E, Gillespie D, Zachos G. Phosphorylation at serine 331 is required for Aurora B activation. J Cell Biol. 2011;195:449-66 pubmed publisher
    b>Aurora B kinase activity is required for successful cell division...
  19. Oh H, Kim M, Song S, Kim T, Lee D, Kwon S, et al. MST1 limits the kinase activity of aurora B to promote stable kinetochore-microtubule attachment. Curr Biol. 2010;20:416-22 pubmed publisher
    ..We now show that MST1 promotes accurate kinetochore-microtubule attachment by modulating the kinase activity of Aurora B. HeLa cells depleted of MST1 failed to develop stable end-on kinetochore-microtubule attachment, giving rise to ..
  20. Wheatley S, Henzing A, Dodson H, Khaled W, Earnshaw W. Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo. J Biol Chem. 2004;279:5655-60 pubmed
    ..These data suggest that phosphorylation of survivin at threonine 117 by aurora-B may regulate targeting of survivin, and possibly the entire passenger complex, in mammals. ..
  21. Qi G, Ogawa I, Kudo Y, Miyauchi M, Siriwardena B, Shimamoto F, et al. Aurora-B expression and its correlation with cell proliferation and metastasis in oral cancer. Virchows Arch. 2007;450:297-302 pubmed
    ..These findings suggest that Aurora-B may be involved in tumor progression and that Aurora-B can be a new diagnostic and therapeutic target for OSCC. ..
  22. Kasuboski J, Bader J, Vaughan P, Tauhata S, Winding M, Morrissey M, et al. Zwint-1 is a novel Aurora B substrate required for the assembly of a dynein-binding platform on kinetochores. Mol Biol Cell. 2011;22:3318-30 pubmed publisher
    b>Aurora B (AurB) is a mitotic kinase responsible for multiple aspects of mitotic progression, including assembly of the outer kinetochore...
  23. Girdler F, Gascoigne K, Eyers P, Hartmuth S, Crafter C, Foote K, et al. Validating Aurora B as an anti-cancer drug target. J Cell Sci. 2006;119:3664-75 pubmed
    ..Using molecular genetic approaches, we show that inhibition of Aurora B kinase activity phenocopies ZM447439...
  24. Lucena Araujo A, de Oliveira F, Leite Cueva S, Dos Santos G, Falcao R, Rego E. High expression of AURKA and AURKB is associated with unfavorable cytogenetic abnormalities and high white blood cell count in patients with acute myeloid leukemia. Leuk Res. 2011;35:260-4 pubmed publisher
    ..001). In conclusion, we described a significant association between overexpression of AURKA/B and cytogenetics findings in AML, which may be relevant to new therapeutic approaches, based on Aurora kinase inhibitors. ..
  25. Gassmann R, Carvalho A, Henzing A, Ruchaud S, Hudson D, Honda R, et al. Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle. J Cell Biol. 2004;166:179-91 pubmed
    The chromosomal passenger complex of Aurora B kinase, INCENP, and Survivin has essential regulatory roles at centromeres and the central spindle in mitosis. Here, we describe Borealin, a novel member of the complex...
  26. Steigemann P, Wurzenberger C, Schmitz M, Held M, Guizetti J, Maar S, et al. Aurora B-mediated abscission checkpoint protects against tetraploidization. Cell. 2009;136:473-84 pubmed publisher
    ..First, we found that Aurora B inactivation promotes completion of cytokinesis by abscission...
  27. Sharma A, Madhunapantula S, Gowda R, Berg A, Neves R, Robertson G. Identification of aurora kinase B and Wee1-like protein kinase as downstream targets of (V600E)B-RAF in melanoma. Am J Pathol. 2013;182:1151-62 pubmed publisher
    ..Involvement of aurora kinase B (AURKB) and Wee1-like protein kinase (WEE1) as downstream proteins in the (V600E)B-RAF pathway was validated ..
  28. Wu D, Asiedu M, Matsumura F, Wei Q. Phosphorylation of myosin II-interacting guanine nucleotide exchange factor (MyoGEF) at threonine 544 by aurora B kinase promotes the binding of polo-like kinase 1 to MyoGEF. J Biol Chem. 2014;289:7142-50 pubmed publisher
    ..In this study we report that aurora B-mediated phosphorylation of MyoGEF at Thr-544 creates a docking site for Plk1, leading to the localization and ..
  29. Honda R, Körner R, Nigg E. Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis. Mol Biol Cell. 2003;14:3325-41 pubmed
    The function of the Aurora B kinase at centromeres and the central spindle is crucial for chromosome segregation and cytokinesis, respectively...
  30. Pouwels J, Kukkonen A, Lan W, Daum J, Gorbsky G, Stukenberg T, et al. Shugoshin 1 plays a central role in kinetochore assembly and is required for kinetochore targeting of Plk1. Cell Cycle. 2007;6:1579-85 pubmed
    ..Here we show that depletion or chemical inhibition of Aurora B kinase (AurB), the catalytic subunit of the CPC, disrupts accumulation of Sgo1 on the kinetochores in HeLa cells ..
  31. Liu D, Vader G, Vromans M, Lampson M, Lens S. Sensing chromosome bi-orientation by spatial separation of aurora B kinase from kinetochore substrates. Science. 2009;323:1350-3 pubmed publisher
    ..b>Aurora B kinase regulates chromosome-spindle attachments by phosphorylating kinetochore substrates that bind microtubules...
  32. Knauer S, Bier C, Habtemichael N, Stauber R. The Survivin-Crm1 interaction is essential for chromosomal passenger complex localization and function. EMBO Rep. 2006;7:1259-65 pubmed
    ..By contrast, CPC assembly does not seem to require the Survivin-Crm1 interaction. Our report shows the functional significance of the Survivin-Crm1 interface and provides a novel link between the mitotic effector Crm1 and the CPC. ..
  33. Song S, Kim S, Song M, Lim D. Aurora B-mediated phosphorylation of RASSF1A maintains proper cytokinesis by recruiting Syntaxin16 to the midzone and midbody. Cancer Res. 2009;69:8540-4 pubmed publisher
    b>Aurora B is critically involved in ensuring proper cytokinesis and maintaining genomic stability...
  34. Yang Y, Wu F, Ward T, Yan F, Wu Q, Wang Z, et al. Phosphorylation of HsMis13 by Aurora B kinase is essential for assembly of functional kinetochore. J Biol Chem. 2008;283:26726-36 pubmed publisher
    ..Here we show that phosphorylation of human HsMis13 by Aurora B kinase is required for functional kinetochore assembly in HeLa cells...
  35. Sugiyama K, Sugiura K, Hara T, Sugimoto K, Shima H, Honda K, et al. Aurora-B associated protein phosphatases as negative regulators of kinase activation. Oncogene. 2002;21:3103-11 pubmed
    ..We found that this enzyme is an arginine-directed kinase that can phosphorylate histone H3 at serines 10 and 28 in vitro, suggesting that human Aurora-B is a mitotic histone H3 kinase. ..
  36. Joo H, Zhai L, Yang C, Nie S, Erdjument Bromage H, Tempst P, et al. Regulation of cell cycle progression and gene expression by H2A deubiquitination. Nature. 2007;449:1068-72 pubmed
    ..This study identifies the major deubiquitinase for histone H2A and demonstrates that H2A deubiquitination is critically involved in cell cycle progression and gene expression. ..
  37. Chen H, Tang C, Chen C, Tang T. Overexpression of an Aurora-C kinase-deficient mutant disrupts the Aurora-B/INCENP complex and induces polyploidy. J Biomed Sci. 2005;12:297-310 pubmed
    ..Together, our results showed that Aurora-C is a chromosomal passenger protein, which may serve as a key regulator in cell division. ..
  38. Ozlu N, Monigatti F, Renard B, Field C, Steen H, Mitchison T, et al. Binding partner switching on microtubules and aurora-B in the mitosis to cytokinesis transition. Mol Cell Proteomics. 2010;9:336-50 pubmed publisher
    ..Concretely, we report a central role for Aurora-B in regulating the C phase cytoskeleton. ..
  39. Sun L, Gao J, Dong X, Liu M, Li D, Shi X, et al. EB1 promotes Aurora-B kinase activity through blocking its inactivation by protein phosphatase 2A. Proc Natl Acad Sci U S A. 2008;105:7153-8 pubmed publisher
    ..These findings establish Aurora-B as an EB1-interacting protein and suggest that EB1 stimulates Aurora-B activity through antagonizing its dephosphorylation/inactivation by PP2A. ..
  40. Yasui Y, Urano T, Kawajiri A, Nagata K, Tatsuka M, Saya H, et al. Autophosphorylation of a newly identified site of Aurora-B is indispensable for cytokinesis. J Biol Chem. 2004;279:12997-3003 pubmed
    ..These results indicate that the phosphorylation of Thr-232 is an essential regulatory mechanism for Aurora-B activation. ..
  41. Gully C, Velazquez Torres G, Shin J, Fuentes Mattei E, Wang E, Carlock C, et al. Aurora B kinase phosphorylates and instigates degradation of p53. Proc Natl Acad Sci U S A. 2012;109:E1513-22 pubmed publisher
    b>Aurora B is a mitotic checkpoint kinase that plays a pivotal role in the cell cycle, ensuring correct chromosome segregation and normal progression through mitosis...
  42. Chen Y, Chen C, Twu N, Yen M, Lai C, Wu H, et al. Overexpression of Aurora B is associated with poor prognosis in epithelial ovarian cancer patients. Virchows Arch. 2009;455:431-40 pubmed publisher
    Recent studies have indicated that Aurora B expression is related to cell proliferation and prognosis in many cancers, but its association with epithelial ovarian carcinoma is not fully understood...
  43. Gruneberg U, Neef R, Honda R, Nigg E, Barr F. Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2. J Cell Biol. 2004;166:167-72 pubmed
    ..of MKlp1 and MKlp2, two vertebrate mitotic kinesins essential for cytokinesis, in the spatial regulation of the Aurora B kinase...
  44. Lampson M, Renduchitala K, Khodjakov A, Kapoor T. Correcting improper chromosome-spindle attachments during cell division. Nat Cell Biol. 2004;6:232-7 pubmed
    ..Our results provide direct evidence for a mechanism required for the maintenance of genome integrity during cell division. ..
  45. Sampath S, Ohi R, Leismann O, Salic A, Pozniakovski A, Funabiki H. The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly. Cell. 2004;118:187-202 pubmed publisher
    ..B, two new components of the vertebrate chromosomal passenger complex containing Incenp, Survivin, and the kinase Aurora B, and demonstrate that this complex is required for chromatin-induced microtubule stabilization and spindle ..
  46. Vázquez Novelle M, Petronczki M. Relocation of the chromosomal passenger complex prevents mitotic checkpoint engagement at anaphase. Curr Biol. 2010;20:1402-7 pubmed publisher
    ..prevents mitotic checkpoint reactivation when sister centromeres are split and tension is lost at anaphase onset? Aurora B kinase, the catalytic subunit of the chromosomal passenger protein complex (CPC) [7], acts as a sensor at inner ..
  47. Ban R, Matsuzaki H, Akashi T, Sakashita G, Taniguchi H, Park S, et al. Mitotic regulation of the stability of microtubule plus-end tracking protein EB3 by ubiquitin ligase SIAH-1 and Aurora mitotic kinases. J Biol Chem. 2009;284:28367-81 pubmed publisher
    ..Our results provide new insight into a regulatory mechanism of +TIPs in cell cycle transition. ..
  48. Guo J, Anderson M, Tapang P, Palma J, Rodriguez L, Niquette A, et al. Identification of genes that confer tumor cell resistance to the aurora B kinase inhibitor, AZD1152. Pharmacogenomics J. 2009;9:90-102 pubmed publisher
    AZD1152 is a highly selective Aurora B kinase inhibitor currently undergoing Phase I and II clinical evaluation in patients with acute myelogenous leukemia and advanced solid malignancies...
  49. Wheatley S, Barrett R, Andrews P, Medema R, Morley S, Swedlow J, et al. Phosphorylation by aurora-B negatively regulates survivin function during mitosis. Cell Cycle. 2007;6:1220-30 pubmed
    Survivin operates in a complex with aurora B kinase and is phosphorylated by it on threonine 117 in vitro. Here we ask whether phosphorylation of survivin by aurora B kinase regulates its function during mitosis in vivo...
  50. Takeshita M, Koga T, Takayama K, Ijichi K, Yano T, Maehara Y, et al. Aurora-B overexpression is correlated with aneuploidy and poor prognosis in non-small cell lung cancer. Lung Cancer. 2013;80:85-90 pubmed publisher
    ..Thus, Aurora-B may serve as a new therapeutic target in against patients with NSCLC, although further studies will be necessary...
  51. Wang E, Ballister E, Lampson M. Aurora B dynamics at centromeres create a diffusion-based phosphorylation gradient. J Cell Biol. 2011;194:539-49 pubmed publisher
    b>Aurora B kinase is essential for successful cell division and regulates spindle assembly and kinetochore-microtubule interactions...
  52. Lipp J, Hirota T, Poser I, Peters J. Aurora B controls the association of condensin I but not condensin II with mitotic chromosomes. J Cell Sci. 2007;120:1245-55 pubmed
    ..Here we show that the mitotic kinase Aurora B regulates the association of condensin I, but not the interaction of condensin II with chromatin...
  53. Welburn J, Vleugel M, Liu D, Yates J, Lampson M, Fukagawa T, et al. Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface. Mol Cell. 2010;38:383-92 pubmed publisher
    ..Here we demonstrate that Aurora B kinase phosphorylates three spatially distinct targets within the conserved outer kinetochore KNL1/Mis12 complex/..
  54. Morozova O, Vojvodic M, Grinshtein N, Hansford L, Blakely K, Maslova A, et al. System-level analysis of neuroblastoma tumor-initiating cells implicates AURKB as a novel drug target for neuroblastoma. Clin Cancer Res. 2010;16:4572-82 pubmed publisher
    ..study revealed that genes in the BRCA1 signaling pathway are frequently misexpressed in NB TICs and implicated Aurora B kinase as a potential drug target for NB therapy...
  55. Saurin A, van der Waal M, Medema R, Lens S, Kops G. Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis. Nat Commun. 2011;2:316 pubmed publisher
    The mitotic checkpoint prevents mitotic exit until all chromosomes are attached to spindle microtubules. Aurora B kinase indirectly invokes this checkpoint by destabilizing incorrect attachments; however, a more direct role remains ..
  56. Fuller B, Lampson M, Foley E, Rosasco Nitcher S, Le K, Tobelmann P, et al. Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient. Nature. 2008;453:1132-6 pubmed publisher
    ..Here we examine the anaphase dynamics of protein phosphorylation by aurora B kinase, a key mitotic regulator, using fluorescence resonance energy transfer (FRET)-based sensors in living HeLa ..
  57. Borges K, Moreno D, Martinelli C, Antonini S, de Castro M, Tucci S, et al. Spindle assembly checkpoint gene expression in childhood adrenocortical tumors (ACT): Overexpression of Aurora kinases A and B is associated with a poor prognosis. Pediatr Blood Cancer. 2013;60:1809-16 pubmed publisher
    ..R337H mutation. Our results suggest that AURKA and AURKB overexpression in pediatric ACT may be related to more aggressive disease and the inhibition of these proteins could be an interesting approach for the treatment of these tumors. ..
  58. Wheatley S, Carvalho A, Vagnarelli P, Earnshaw W. INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis. Curr Biol. 2001;11:886-90 pubmed
    ..Our data provide the first biochemical evidence that Survivin can interact directly with members of the chromosomal passenger complex. ..
  59. Tsukahara T, Tanno Y, Watanabe Y. Phosphorylation of the CPC by Cdk1 promotes chromosome bi-orientation. Nature. 2010;467:719-23 pubmed publisher
    ..chromosome bi-orientation at prometaphase, the chromosomal passenger complex (CPC), composed of catalytic kinase Aurora B and regulatory components (INCENP, Survivin and Borealin), must be localized to centromeres to phosphorylate ..
  60. Beardmore V, Ahonen L, Gorbsky G, Kallio M. Survivin dynamics increases at centromeres during G2/M phase transition and is regulated by microtubule-attachment and Aurora B kinase activity. J Cell Sci. 2004;117:4033-42 pubmed
    ..Survivin physically associates with Aurora B, a serine-threonine kinase involved in microtubule attachment to centromeres and regulation of chromosome ..
  61. Tien A, Lin M, Su L, Hong Y, Cheng T, Lee Y, et al. Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model. Mol Cell Proteomics. 2004;3:93-104 pubmed
    ..Together, these results justify the timely implementation of in silico biology in routine wet-lab studies and have also allowed the application of a new approach to the elucidation of protein function in the post-genomic era. ..
  62. Kawajiri A, Yasui Y, Goto H, Tatsuka M, Takahashi M, Nagata K, et al. Functional significance of the specific sites phosphorylated in desmin at cleavage furrow: Aurora-B may phosphorylate and regulate type III intermediate filaments during cytokinesis coordinatedly with Rho-kinase. Mol Biol Cell. 2003;14:1489-500 pubmed
    ..The results presented here suggest the possibility that Aurora-B may regulate cleavage furrow-specific phosphorylation and segregation of type III IFs coordinatedly with Rho-kinase during cytokinesis. ..
  63. Mendiola M, Barriuso J, Mariño Enríquez A, Redondo A, Domínguez Cáceres A, Hernández Cortés G, et al. Aurora kinases as prognostic biomarkers in ovarian carcinoma. Hum Pathol. 2009;40:631-8 pubmed publisher
    ..03) and overall survival (P = .02). In conclusion, Aurora A expression seems to have a prognostic value in ovarian carcinoma. ..
  64. Morrow C, Tighe A, Johnson V, Scott M, Ditchfield C, Taylor S. Bub1 and aurora B cooperate to maintain BubR1-mediated inhibition of APC/CCdc20. J Cell Sci. 2005;118:3639-52 pubmed
    ..However, in human somatic cells Bub1 and aurora B kinase activity do not appear to be essential for spindle checkpoint function...
  65. Hirota T, Lipp J, Toh B, Peters J. Histone H3 serine 10 phosphorylation by Aurora B causes HP1 dissociation from heterochromatin. Nature. 2005;438:1176-80 pubmed
    ..During mitosis, H3 is also phosphorylated by the kinase Aurora B. Although H3 phosphorylation is a hallmark of mitosis, its function remains mysterious...
  66. Chen J, Jin S, Tahir S, Zhang H, Liu X, Sarthy A, et al. Survivin enhances Aurora-B kinase activity and localizes Aurora-B in human cells. J Biol Chem. 2003;278:486-90 pubmed
    ..These results indicate that survivin stimulates Aurora-B kinase activity and helps correctly target Aurora-B to its substrates during the cell cycle, thus providing a mechanism as to how survivin exerts its function in human cells. ..
  67. Sakita Suto S, Kanda A, Suzuki F, Sato S, Takata T, Tatsuka M. Aurora-B regulates RNA methyltransferase NSUN2. Mol Biol Cell. 2007;18:1107-17 pubmed
    ..These results indicate that Aurora-B participates to regulate the assembly of nucleolar RNA-processing machinery and the RNA methyltransferase activity of NSUN2 via phosphorylation at Ser139 during mitosis. ..
  68. Tanenbaum M, Macurek L, van der Vaart B, Galli M, Akhmanova A, Medema R. A complex of Kif18b and MCAK promotes microtubule depolymerization and is negatively regulated by Aurora kinases. Curr Biol. 2011;21:1356-65 pubmed publisher
    ..Together, these results uncover a novel role for Aurora kinases in regulating spindle MT dynamics through Kif18b-MCAK and suggest that the Kif18b-MCAK complex constitutes the major MT plus-end depolymerizing activity in mitotic cells. ..
  69. Perrera C, Colombo R, Valsasina B, Carpinelli P, Troiani S, Modugno M, et al. Identification of Myb-binding protein 1A (MYBBP1A) as a novel substrate for aurora B kinase. J Biol Chem. 2010;285:11775-85 pubmed publisher
    ..Using biochemical, mass spectrometric, and cellular approaches, we identified MYBBP1A as a novel Aurora B substrate and serine 1303 as the major phosphorylation site...
  70. Ryser S, Dizin E, Jefford C, Delaval B, Gagos S, Christodoulidou A, et al. Distinct roles of BARD1 isoforms in mitosis: full-length BARD1 mediates Aurora B degradation, cancer-associated BARD1beta scaffolds Aurora B and BRCA2. Cancer Res. 2009;69:1125-34 pubmed publisher
    ..BARD1, but not BRCA1, localizes to the midbody at telophase and cytokinesis, where it colocalizes with Aurora B. The 97-kDa full-length (FL) BARD1 coimmunoprecipates with BRCA1, but the 82-kDa BARD1beta coimmunoprecipitates ..
  71. Sumara I, Quadroni M, Frei C, Olma M, Sumara G, Ricci R, et al. A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells. Dev Cell. 2007;12:887-900 pubmed
    ..b>Aurora B directly binds to the substrate-recognition domain of KLHL9 and KLHL13 in vitro, and coimmunoprecipitates with ..
  72. Shindo M, Nakano H, Kuroyanagi H, Shirasawa T, Mihara M, Gilbert D, et al. cDNA cloning, expression, subcellular localization, and chromosomal assignment of mammalian aurora homologues, aurora-related kinase (ARK) 1 and 2. Biochem Biophys Res Commun. 1998;244:285-92 pubmed
    ..Here we have identified mammalian aurora homologues, designated aurora-related kinase (ARK) 1 and ARK2. Kinase domains of murine ARK1 and ARK2 showed 61 and 62% identity, respectively, to that of aurora at the amino ..
  73. Tatsuka M, Katayama H, Ota T, Tanaka T, Odashima S, Suzuki F, et al. Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells. Cancer Res. 1998;58:4811-6 pubmed
    Aurora- and Ipl1-like midbody-associated protein (AIM-1) is a serine/ threonine kinase that is structurally related to Drosophila aurora and Saccharomyces cerevisiae Ipl1, both of which are required for chromosome segregation...
  74. Nozawa R, Nagao K, Masuda H, Iwasaki O, Hirota T, Nozaki N, et al. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. Nat Cell Biol. 2010;12:719-27 pubmed publisher
    ..Furthermore, POGZ is required for the correct activation and dissociation of Aurora B kinase from chromosome arms during M phase...
  75. Douglas M, Davies T, Joseph N, Mishima M. Aurora B and 14-3-3 coordinately regulate clustering of centralspindlin during cytokinesis. Curr Biol. 2010;20:927-33 pubmed publisher
    ..Stable accumulation of centralspindlin at the spindle midzone requires its multimerization into clusters and Aurora B kinase activity, which peaks at the central spindle during anaphase...
  76. Vader G, Kauw J, Medema R, Lens S. Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody. EMBO Rep. 2006;7:85-92 pubmed
    ..Thus, Survivin is an important mediator of centromere and midbody docking of Aurora-B during mitosis. ..
  77. Yang C, Tang X, Guo X, Niikura Y, Kitagawa K, Cui K, et al. Aurora-B mediated ATM serine 1403 phosphorylation is required for mitotic ATM activation and the spindle checkpoint. Mol Cell. 2011;44:597-608 pubmed publisher
    ..ATM-mediated Bub1 Ser314 phosphorylation is required for Bub1 activity and is essential for the activation of the spindle checkpoint. Collectively, our data highlight mechanisms of a critical function of ATM in mitosis. ..
  78. Ikezoe T, Takeuchi T, Yang J, Adachi Y, Nishioka C, Furihata M, et al. Analysis of Aurora B kinase in non-Hodgkin lymphoma. Lab Invest. 2009;89:1364-73 pubmed publisher
    This study explored the levels of Aurora B, a key regulator of mitosis, in 71 lymph nodes and tumor specimens excised operatively from individuals with various types of non-Hodgkin lymphoma (NHLs)...
  79. Jeyaprakash A, Klein U, Lindner D, Ebert J, Nigg E, Conti E. Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together. Cell. 2007;131:271-85 pubmed
    ..three components of the CPC that regulate the activity and localization of its enzymatic component, the kinase Aurora B. We determined the 1...
  80. Kawashima S, Tsukahara T, Langegger M, Hauf S, Kitajima T, Watanabe Y. Shugoshin enables tension-generating attachment of kinetochores by loading Aurora to centromeres. Genes Dev. 2007;21:420-35 pubmed
    ..We propose that ensuring bipolar attachment of kinetochores is the primary role of shugoshin and the role of cohesion protection might have codeveloped to facilitate this process. ..
  81. Banerjee B, Kestner C, Stukenberg P. EB1 enables spindle microtubules to regulate centromeric recruitment of Aurora B. J Cell Biol. 2014;204:947-63 pubmed publisher
    The Aurora B kinase coordinates kinetochore-microtubule attachments with spindle checkpoint signaling on each mitotic chromosome...
  82. Wu L, Ma C, Zhao Y, Jain A. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression. J Biol Chem. 2011;286:2236-44 pubmed publisher
    ..Using a proteomic approach, we have identified the Aurora kinase B as a novel binding partner of NIR...
  83. Schmidt J, Kiyomitsu T, Hori T, Backer C, Fukagawa T, Cheeseman I. Aurora B kinase controls the targeting of the Astrin-SKAP complex to bioriented kinetochores. J Cell Biol. 2010;191:269-80 pubmed publisher
    ..Although most dynein-associated proteins localize to unaligned kinetochores in an Aurora B-dependent manner, Astrin, SKAP, and LC8 localization is antagonized by Aurora B such that they target exclusively ..
  84. Sasai K, Katayama H, Stenoien D, Fujii S, Honda R, Kimura M, et al. Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells. Cell Motil Cytoskeleton. 2004;59:249-63 pubmed
    ..Finally, Aurora-C could rescue the Aurora-B silenced multinucleation phenotype, demonstrating that Aurora-C kinase function overlaps with and complements Aurora-B kinase function in mitosis. ..