Gene Symbol: AHSG
Description: alpha 2-HS glycoprotein
Alias: A2HS, AHS, APMR1, FETUA, HSGA, alpha-2-HS-glycoprotein, alpha-2-Z-globulin, ba-alpha-2-glycoprotein, fetuin-A
Species: human
Products:     AHSG

Top Publications

  1. Rittig K, Thamer C, Haupt A, Machann J, Peter A, Balletshofer B, et al. High plasma fetuin-A is associated with increased carotid intima-media thickness in a middle-aged population. Atherosclerosis. 2009;207:341-2 pubmed publisher
  2. Saroha A, Kumar S, Chatterjee B, Das H. Jacalin bound plasma O-glycoproteome and reduced sialylation of alpha 2-HS glycoprotein (A2HSG) in rheumatoid arthritis patients. PLoS ONE. 2012;7:e46374 pubmed publisher
    ..Altered glycoprotein expression and functional as well as structural studies of glycans might help in the diagnosis of RA and understanding the disease pathogenesis. ..
  3. Sakwe A, Koumangoye R, Goodwin S, Ochieng J. Fetuin-A ({alpha}2HS-glycoprotein) is a major serum adhesive protein that mediates growth signaling in breast tumor cells. J Biol Chem. 2010;285:41827-35 pubmed publisher
    ..Taken together, our data show the significance of fetuin-A in tumor cell growth mechanisms in vitro and open new research vistas for this protein. ..
  4. Eraso L, Ginwala N, Qasim A, Mehta N, Dlugash R, Kapoor S, et al. Association of lower plasma fetuin-a levels with peripheral arterial disease in type 2 diabetes. Diabetes Care. 2010;33:408-10 pubmed publisher
    ..Our findings suggest a potentially unique role for fetuin-A deficiency as a biomarker of PAD in patients with type 2 diabetes. ..
  5. Porazko T, Kuzniar J, Kusztal M, Kuzniar T, Weyde W, Kuriata Kordek M, et al. Increased aortic wall stiffness associated with low circulating fetuin A and high C-reactive protein in predialysis patients. Nephron Clin Pract. 2009;113:c81-7 pubmed publisher
    ..The aim of the study was to analyze relationships between inflammatory markers, fetuin A and arterial wall stiffness in CKD patients in the predialysis period and on maintenance dialysis...
  6. Kaess B, Enserro D, McManus D, Xanthakis V, Chen M, Sullivan L, et al. Cardiometabolic correlates and heritability of fetuin-A, retinol-binding protein 4, and fatty-acid binding protein 4 in the Framingham Heart Study. J Clin Endocrinol Metab. 2012;97:E1943-7 pubmed publisher
  7. Ix J, Shlipak M, Brandenburg V, Ali S, Ketteler M, Whooley M. Association between human fetuin-A and the metabolic syndrome: data from the Heart and Soul Study. Circulation. 2006;113:1760-7 pubmed
    ..01). Higher human fetuin-A concentrations are strongly associated with MetS and an atherogenic lipid profile. Future studies should evaluate whether fetuin-A predicts coronary artery disease risk. ..
  8. Dowling P, Clarke C, Hennessy K, Torralbo Lopez B, Ballot J, Crown J, et al. Analysis of acute-phase proteins, AHSG, C3, CLI, HP and SAA, reveals distinctive expression patterns associated with breast, colorectal and lung cancer. Int J Cancer. 2012;131:911-23 pubmed publisher
    ..We have previously demonstrated that levels of alpha-2-heremans-schmid-glycoprotein (AHSG), complement component C3 (C3), clusterin (CLI), haptoglobin (HP) and serum amyloid A (SAA) are significantly ..
  9. Axelsson J, Wang X, Ketteler M, Qureshi A, Heimburger O, Barany P, et al. Is fetuin-A/alpha2-Heremans-Schmid glycoprotein associated with the metabolic syndrome in patients with chronic kidney disease?. Am J Nephrol. 2008;28:669-76 pubmed publisher
    ..We hypothesized that the circulating calcification inhibitor fetuin-A/AHSG, which is also a natural inhibitor of the tyrosine kinase insulin receptor, could be one factor explaining the ..

More Information


  1. Dahlman I, Eriksson P, Kaaman M, Jiao H, Lindgren C, Kere J, et al. alpha2-Heremans-Schmid glycoprotein gene polymorphisms are associated with adipocyte insulin action. Diabetologia. 2004;47:1974-9 pubmed
    ..of single-nucleotide polymorphisms (SNPs) in the gene encoding the human alpha(2)-Heremans-Schmid glycoprotein (AHSG) on obesity and insulin action in adipocytes. We screened 24 individuals for SNPs in AHSG...
  2. Oikawa O, Higuchi T, Yamazaki T, Yamamoto C, Fukuda N, Matsumoto K. Evaluation of serum fetuin-A relationships with biochemical parameters in patients on hemodialysis. Clin Exp Nephrol. 2007;11:304-308 pubmed publisher
    ..05). These data suggest that a low fetuin-A level is a useful predictor of malnutrition and inflammation, as well as being a useful predictor of the cardiac failure caused by an increased ventricular load in hemodialysis patients. ..
  3. Reinehr T, Roth C. Fetuin-A and its relation to metabolic syndrome and fatty liver disease in obese children before and after weight loss. J Clin Endocrinol Metab. 2008;93:4479-85 pubmed publisher
    ..Therefore, fetuin-A might be a new promising link between obesity and its comorbidities. ..
  4. Fisher E, Stefan N, Saar K, Drogan D, Schulze M, Fritsche A, et al. Association of AHSG gene polymorphisms with fetuin-A plasma levels and cardiovascular diseases in the EPIC-Potsdam study. Circ Cardiovasc Genet. 2009;2:607-13 pubmed publisher
    ..capturing the common genetic variation of the fetuin-A coding gene alpha(2)-Heremans-Schmid glycoprotein (AHSG) were genotyped in a case-cohort comprising 214 MI cases, 154 ischemic stroke cases, and 2152 persons who remained ..
  5. Ix J, Biggs M, Mukamal K, Kizer J, Zieman S, Siscovick D, et al. Association of fetuin-a with incident diabetes mellitus in community-living older adults: the cardiovascular health study. Circulation. 2012;125:2316-22 pubmed publisher
    ..01). Higher fetuin-A is associated with incident diabetes mellitus in older persons regardless of sex, race, or prevalent CVD status. The association may be attenuated in those ≥ 75 years of age. ..
  6. Ou H, Wu H, Hung H, Yang Y, Wu J, Chang C. Endoplasmic reticulum stress induces the expression of fetuin-A to develop insulin resistance. Endocrinology. 2012;153:2974-84 pubmed publisher
    ..Moreover, ER stress induced by high glucose and palmitate increased the expression of fetuin-A and further contributed to the development of insulin resistance. ..
  7. Caglar K, Yilmaz M, Saglam M, Cakir E, Kilic S, Sonmez A, et al. Serum fetuin-a concentration and endothelial dysfunction in chronic kidney disease. Nephron Clin Pract. 2008;108:c233-40 pubmed publisher
    ..216, p < 0.001). These data in a selected cohort of CKD patients indicate that fetuin-A may be one of the contributing factors for the development of endothelial dysfunction in CKD patients. ..
  8. Andersen G, Burgdorf K, Sparsø T, Borch Johnsen K, Jørgensen T, Hansen T, et al. AHSG tag single nucleotide polymorphisms associate with type 2 diabetes and dyslipidemia: studies of metabolic traits in 7,683 white Danish subjects. Diabetes. 2008;57:1427-32 pubmed publisher
    The gene encoding the alpha2 Heremans-Schmid glycoprotein (AHSG) is a credible biological and positional candidate gene for type 2 diabetes and the metabolic syndrome, and previous attempts to relate AHSG variation with type 2 diabetes ..
  9. Jersmann H, Dransfield I, Hart S. Fetuin/alpha2-HS glycoprotein enhances phagocytosis of apoptotic cells and macropinocytosis by human macrophages. Clin Sci (Lond). 2003;105:273-8 pubmed
    ..Fetuin also substantially increased the uptake of labelled dextran 70000 by macrophages, which occurs by macropinocytosis, suggesting that this may be one of the mechanisms utilized for apoptotic cell uptake. ..
  10. Roos M, Richart T, Kouznetsova T, von Eynatten M, Lutz J, Heemann U, et al. Fetuin-A and arterial stiffness in patients with normal kidney function. Regul Pept. 2009;154:39-43 pubmed publisher
    To evaluate the association between fetuin-A level (AHSG), its encoding gene (Thr256Ser) and arterial function in subjects with normal kidney function. The aortic pulse wave velocity (aPWV) is a predictor for cardiovascular mortality...
  11. Jahnen Dechent W, Heiss A, Schafer C, Ketteler M. Fetuin-A regulation of calcified matrix metabolism. Circ Res. 2011;108:1494-509 pubmed publisher
    ..Fetuin-A deficiency is associated with soft tissue calcification in mice and humans. ..
  12. Yilmaz Y, Yonal O, Kurt R, Ari F, Oral A, Celikel C, et al. Serum fetuin A/?2HS-glycoprotein levels in patients with non-alcoholic fatty liver disease: relation with liver fibrosis. Ann Clin Biochem. 2010;47:549-53 pubmed publisher
    Serum concentrations of fetuin A/?2HS-glycoprotein (AHSG) have been linked to human metabolic alterations and can serve as an indicator of liver cell function...
  13. Inoue M, Takata H, Ikeda Y, Suehiro T, Inada S, Osaki F, et al. A promoter polymorphism of the alpha2-HS glycoprotein gene is associated with its transcriptional activity. Diabetes Res Clin Pract. 2008;79:164-70 pubmed
    alpha2-Heremans Schmid glycoprotein (AHSG), also designated fetuin-A, is an abundant plasma protein that is expressed in hepatocytes...
  14. Karamessinis P, Malamitsi Puchner A, Boutsikou T, Makridakis M, Vougas K, Fountoulakis M, et al. Marked defects in the expression and glycosylation of alpha2-HS glycoprotein/fetuin-A in plasma from neonates with intrauterine growth restriction: proteomics screening and potential clinical implications. Mol Cell Proteomics. 2008;7:591-9 pubmed
    ..b>Fetuin A is a glycoprotein that has been associated with promotion of in vitro cell replication, fetal growth and ..
  15. Emoto M, Mori K, Lee E, Kawano N, Yamazaki Y, Tsuchikura S, et al. Fetuin-A and atherosclerotic calcified plaque in patients with type 2 diabetes mellitus. Metabolism. 2010;59:873-8 pubmed publisher
    ..753; 95% confidence interval, 0.608-0.933; P = .010). These results suggest that fetuin-A may inhibit the calcification of atherosclerotic plaques independently of the dialyzed condition. ..
  16. Caglar K, Yilmaz M, Saglam M, Cakir E, Kilic S, Eyileten T, et al. Endothelial dysfunction and fetuin A levels before and after kidney transplantation. Transplantation. 2007;83:392-7 pubmed
    ..The aim of this study was to investigate the relation between fetuin A levels and ED in kidney transplant recipients...
  17. Haukeland J, Dahl T, Yndestad A, Gladhaug I, Løberg E, Haaland T, et al. Fetuin A in nonalcoholic fatty liver disease: in vivo and in vitro studies. Eur J Endocrinol. 2012;166:503-10 pubmed publisher
    b>Fetuin A has been associated with insulin resistance and the metabolic syndrome. We therefore explored the role of fetuin A in nonalcoholic fatty liver disease (NAFLD). Cross-sectional and intervention studies...
  18. Hennige A, Staiger H, Wicke C, Machicao F, Fritsche A, Haring H, et al. Fetuin-A induces cytokine expression and suppresses adiponectin production. PLoS ONE. 2008;3:e1765 pubmed publisher
    The secreted liver protein fetuin-A (AHSG) is up-regulated in hepatic steatosis and the metabolic syndrome. These states are strongly associated with low-grade inflammation and hypoadiponectinemia...
  19. Stefan N, Fritsche A, Weikert C, Boeing H, Joost H, Haring H, et al. Plasma fetuin-A levels and the risk of type 2 diabetes. Diabetes. 2008;57:2762-7 pubmed publisher
    ..05 [1.02-1.07]). Furthermore, fetuin-A was associated with increased diabetes risk particularly in individuals with elevated plasma glucose. Our data suggest that fetuin-A is an independent risk factor of type 2 diabetes. ..
  20. Jenkins N, McKenzie J, Hagberg J, Witkowski S. Plasma fetuin-A concentrations in young and older high- and low-active men. Metabolism. 2011;60:265-71 pubmed publisher
    ..Therefore, the maintenance of low levels of circulating fetuin-A may be a novel mechanism contributing to enhanced insulin sensitivity with regular physical activity. ..
  21. Ketteler M, Bongartz P, Westenfeld R, Wildberger J, Mahnken A, Böhm R, et al. Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: a cross-sectional study. Lancet. 2003;361:827-33 pubmed
    ..Fetuin-A (alpha2-Heremans Schmid glycoprotein; AHSG) is an important circulating inhibitor of calcification in vivo, and is downregulated during the acute-phase ..
  22. Haglund A, Ek B, Ek P. Phosphorylation of human plasma alpha2-Heremans-Schmid glycoprotein (human fetuin) in vivo. Biochem J. 2001;357:437-45 pubmed
  23. El Shehaby A, Zakaria A, El Khatib M, Mostafa N. Association of fetuin-A and cardiac calcification and inflammation levels in hemodialysis patients. Scand J Clin Lab Invest. 2010;70:575-82 pubmed publisher
    ..Assessment of both cardiac calcification and serum levels of fetuin-A may be of value to identify those subjects at higher risk of development and progression of vascular lesion and may be a novel therapeutic approach. ..
  24. Osawa M, Tian W, Horiuchi H, Kaneko M, Umetsu K. Association of alpha2-HS glycoprotein (AHSG, fetuin-A) polymorphism with AHSG and phosphate serum levels. Hum Genet. 2005;116:146-51 pubmed
    Alpha2-HS glycoprotein (AHSG), also known as fetuin-A, is a plasma protein displaying high-affinity interaction with calcium phosphate, by which ectopic vascular calcification is prevented...
  25. Lee C, Bowman B, Yang F. Human alpha 2-HS-glycoprotein: the A and B chains with a connecting sequence are encoded by a single mRNA transcript. Proc Natl Acad Sci U S A. 1987;84:4403-7 pubmed
    The alpha 2-HS-glycoprotein (AHSG) is a plasma protein reported to play roles in bone mineralization and in the immune response. It is composed of two subunits, the A and B chains...
  26. Fiore C, Celotta G, Politi G, Di Pino L, Castelli Z, Mangiafico R, et al. Association of high alpha2-Heremans-Schmid glycoprotein/fetuin concentration in serum and intima-media thickness in patients with atherosclerotic vascular disease and low bone mass. Atherosclerosis. 2007;195:110-5 pubmed
    Alpha2-Heremans-Schmid glycoprotein (AHSG; fetuin), a member of the cystatin superfamily of cysteine protease inhibitors involved in vascular pathology and bone metabolism, has been reported to be reduced in patients with atherosclerosis ..
  27. Heiss A, DuChesne A, Denecke B, Grötzinger J, Yamamoto K, Renne T, et al. Structural basis of calcification inhibition by alpha 2-HS glycoprotein/fetuin-A. Formation of colloidal calciprotein particles. J Biol Chem. 2003;278:13333-41 pubmed
    Genetic evidence from mutant mice suggests that alpha(2)-HS glycoprotein/fetuin-A (Ahsg) is a systemic inhibitor of precipitation of basic calcium phosphate preventing unwanted calcification...
  28. Ix J, Wassel C, Kanaya A, Vittinghoff E, Johnson K, Koster A, et al. Fetuin-A and incident diabetes mellitus in older persons. JAMA. 2008;300:182-8 pubmed publisher
    ..72; 95% confidence interval, 0.98-3.05; P = .06). Among well-functioning older persons, serum fetuin-A is associated with incident diabetes, independent of other markers of insulin resistance. ..
  29. Nangami G, Watson K, Parker Johnson K, Okereke K, Sakwe A, Thompson P, et al. Fetuin-A (?2HS-glycoprotein) is a serum chemo-attractant that also promotes invasion of tumor cells through Matrigel. Biochem Biophys Res Commun. 2013;438:660-5 pubmed publisher
    ..The presence of plasminogen (PL) blunted the fetuin-A mediated chemotaxis. Taken together, the data suggest an in vivo chemotaxis/invasion role for fetuin-A. ..
  30. Ix J, Sharma K. Mechanisms linking obesity, chronic kidney disease, and fatty liver disease: the roles of fetuin-A, adiponectin, and AMPK. J Am Soc Nephrol. 2010;21:406-12 pubmed publisher
    ..Regulation of these early upstream pathways may provide new therapeutic targets for these increasingly common sequelae of obesity. ..
  31. Srinivas P, Wagner A, Reddy L, Deutsch D, Leon M, Goustin A, et al. Serum alpha 2-HS-glycoprotein is an inhibitor of the human insulin receptor at the tyrosine kinase level. Mol Endocrinol. 1993;7:1445-55 pubmed
    ..DNA sequence analysis reveals identity with the mRNA product of a human gene AHSG encoding a serum protein, alpha 2-Heremans Scmid-glycoprotein (alpha 2HSG), with heretofore unknown physiological ..
  32. Weikert C, Stefan N, Schulze M, Pischon T, Berger K, Joost H, et al. Plasma fetuin-a levels and the risk of myocardial infarction and ischemic stroke. Circulation. 2008;118:2555-62 pubmed publisher
    ..0001). Our data provide evidence for a link between high plasma fetuin-A levels and an increased risk of MI and IS. Therefore, more research is warranted to determine the role of fetuin-A in the pathophysiology of cardiovascular disease. ..
  33. Cozzolino M, Galassi A, Biondi M, Turri O, Papagni S, Mongelli N, et al. Serum fetuin-A levels link inflammation and cardiovascular calcification in hemodialysis patients. Am J Nephrol. 2006;26:423-9 pubmed
    ..Chronic inflammation in HD patients leads to lower serum fetuin-A levels. The present study confirms the independent and significant association between reduced serum fetuin-A levels and multi-site CVC in HD. ..
  34. Stenvinkel P, Wang K, Qureshi A, Axelsson J, Pecoits Filho R, Gao P, et al. Low fetuin-A levels are associated with cardiovascular death: Impact of variations in the gene encoding fetuin. Kidney Int. 2005;67:2383-92 pubmed
    ..evaluated the association between fetuin-A, clinical phenotype, and outcome, as well as the impact of fetuin gene (AHSG) polymorphisms on the protein product and outcome...
  35. Ketteler M. Fetuin-A and extraosseous calcification in uremia. Curr Opin Nephrol Hypertens. 2005;14:337-42 pubmed
    ..Deficiencies of calcification inhibitors such as fetuin-A are relevant pathomechanisms in the progression of uncontrolled vascular calcification and may offer potential for future therapeutic approaches. ..
  36. Kaden J, Reinöhl J, Blesch B, Brueckmann M, Haghi D, Borggrefe M, et al. Systemic and local levels of fetuin-A in calcific aortic valve stenosis. Int J Mol Med. 2007;20:193-7 pubmed
  37. Osawa M, Umetsu K, Ohki T, Nagasawa T, Suzuki T, Takeichi S. Molecular evidence for human alpha 2-HS glycoprotein (AHSG) polymorphism. Hum Genet. 1997;99:18-21 pubmed
    Alpha 2-HS glycoprotein (AHSG) is a human plasma glycoprotein that exhibits genetic polymorphism on isoelectric focusing (IEF). To identify the origin of two common alleles, AHSG*1 and *2, we examined nucleotide exchanges in the gene...
  38. Siddiq A, Lepretre F, Hercberg S, Froguel P, Gibson F. A synonymous coding polymorphism in the alpha2-Heremans-schmid glycoprotein gene is associated with type 2 diabetes in French Caucasians. Diabetes. 2005;54:2477-81 pubmed
    alpha2-Heremans-Schmid glycoprotein (AHSG) is an abundant plasma protein synthesized predominantly in the liver. The AHSG gene, consisting of seven exons and spanning 8...
  39. Shenton L, Wagner A, Bettampadi D, Masters N, Carlson B, Boulton M. Factors Associated with Vaccination Status of Children Aged 12-48 Months in India, 2012-2013. Matern Child Health J. 2018;22:419-428 pubmed publisher
    ..India's 4th District-level Health and Facility Survey, 2012-2013 (DLHS-4) and the 2012-2013 Annual Health Survey (AHS), we calculated the proportion of children who were non-vaccinated, under-vaccinated, or fully vaccinated with 1 ..
  40. Laughlin G, Cummins K, Wassel C, Daniels L, Ix J. The association of fetuin-A with cardiovascular disease mortality in older community-dwelling adults: the Rancho Bernardo study. J Am Coll Cardiol. 2012;59:1688-96 pubmed publisher
    ..Fetuin-A may provide novel insight into mechanisms leading to CVD death in those with versus without diabetes. ..
  41. Sokolowsky A, Marquez E, Sheehy E, Barber C, Gerstenberger S. Health Hazards in the Home: An Assessment of a Southern Nevada Community. J Community Health. 2017;42:730-738 pubmed publisher
    ..The results were then compared, when possible, to American Housing Survey (AHS) data for the Las Vegas metropolitan area...
  42. Aydin Z, Ozturk S, Celik C, Gursu M, Karadag S, Yamak M, et al. The role of fetuin-A in cardiac functions and metabolism in peritoneal dialysis patients. Minerva Urol Nefrol. 2015;67:375-82 pubmed
    ..PD patients with heart failure have significantly lower fetuin-A levels. Age is a main determinant of fetuin-A level and fetuin-A may act as a negative acute phase reactant in PD patients. ..
  43. Szeberin Z, Fehérvári M, Krepuska M, Apor A, Rimely E, Sarkadi H, et al. Serum fetuin-A levels inversely correlate with the severity of arterial calcification in patients with chronic lower extremity atherosclerosis without renal disease. Int Angiol. 2011;30:474-50 pubmed
    ..These data support a putative protective role for fetuin-A in the development of arterial calcification. ..
  44. Zhou F, Zhou L, Guo T, Wang N, Hao H, Zhou Y, et al. Plasma proteomics reveals coagulation, inflammation, and metabolic shifts in H-type hypertension patients with and without acute ischemic stroke. Oncotarget. 2017;8:100384-100395 pubmed publisher
    ..AT-3, CRP, ApoB, and AHSG were further validated in each group by enzyme-linked immune sorbent assays...
  45. Iliodromiti S, Vrachnis N, Samoli E, Iliodromiti Z, Pangalos C, Drakoulis N, et al. Fetuin A concentration in the second trimester amniotic fluid of fetuses with trisomy 21 appears to be lower: phenotypic considerations. Mediators Inflamm. 2012;2012:138971 pubmed publisher
    We investigated whether the concentration of the glycoprotein fetuin A is altered in the second trimester amniotic fluid of trisomy 21 pregnancies compared with euploid pregnancies...
  46. Eleftheriadou I, Grigoropoulou P, Kokkinos A, Mourouzis I, Perrea D, Katsilambros N, et al. Association of plasma fetuin-a levels with peripheral arterial disease and lower extremity arterial calcification in subjects with type 2 diabetes mellitus. J Diabetes Complications. 2017;31:599-604 pubmed publisher
    ..Plasma fetuin-A levels are lower in patients with T2DM and PAD and are associated with PAD, irrespective of traditional cardiovascular risk factors. Moreover, fetuin-A may be involved in arterial calcification. ..
  47. Himmetoglu S, Teksoz S, Zengin K, Yesim T, Taskin M, Dincer Y. Serum levels of fetuin A and 8-hydroxydeoxyguanosine in morbidly obese subjects. Exp Clin Endocrinol Diabetes. 2013;121:505-8 pubmed publisher
    Insulin resistance is one of the feature of obesity. Fetuin A is inhibitor of insulin receptor which belongs the family of receptor tyrosine kinase...
  48. Sanhal C, Can Kavcar M, Yucel A, Erkenekli K, Erkaya S, Uygur D. Comparison of plasma fetuin A levels in patients with early-onset pre-eclampsia vs late-onset pre-eclampsia. Eur J Obstet Gynecol Reprod Biol. 2016;200:108-12 pubmed publisher
    ..196, 95% CI 0.085-0.306). Early- and late-onset PE were associated with lower and higher levels of FA, respectively. A relationship was found between inflammation and early-onset PE but not late-onset PE. ..
  49. Hortells L, Sosa C, Guillen N, Lucea S, Millan A, Sorribas V. Identifying early pathogenic events during vascular calcification in uremic rats. Kidney Int. 2017;92:1384-1394 pubmed publisher
    ..The expression of other agents involved in vascular calcification only changes at later stages of chronic kidney disease, in a complex branching pattern that requires further clarification. ..
  50. Roos M, Heinemann F, Lindemann M, Horn P, Lutz J, Stock K, et al. Fetuin-A pretransplant serum levels, kidney allograft function and rejection episodes: a 3-year posttransplantation follow-up. Kidney Blood Press Res. 2011;34:328-33 pubmed publisher
    ..Pretransplant levels of fetuin-A are not a predictor for renal allograft loss or rejection episodes after 36 months' follow-up in transplant recipients. ..
  51. Reza Sailani M, Jahanbani F, Nasiri J, Behnam M, Salehi M, Sedghi M, et al. Association of AHSG with alopecia and mental retardation (APMR) syndrome. Hum Genet. 2017;136:287-296 pubmed publisher
    ..Our study revealed a novel predicted pathogenic, homozygous missense mutation in the AHSG (OMIM 138680) gene (AHSG: NM_001622:exon7:c.950G>A:p.Arg317His)...
  52. van de Water S, van Gennip R, Potgieter C, Wright I, van Rijn P. VP2 Exchange and NS3/NS3a Deletion in African Horse Sickness Virus (AHSV) in Development of Disabled Infectious Single Animal Vaccine Candidates for AHSV. J Virol. 2015;89:8764-72 pubmed publisher
    ..AHSV is transmitted by species of Culicoides biting midges and causes African horse sickness (AHS) in equids, with a mortality rate of up to 95% in naive horses...
  53. Molvarec A, Kalabay L, Derzsy Z, Szarka A, Halmos A, Stenczer B, et al. Preeclampsia is associated with decreased serum alpha(2)-HS glycoprotein (fetuin-A) concentration. Hypertens Res. 2009;32:665-9 pubmed publisher
    The purpose of this study was to determine serum alpha(2)-HS glycoprotein (AHSG) concentration and its diagnostic accuracy in preeclampsia...
  54. Naito C, Hashimoto M, Watanabe K, Shirai R, Takahashi Y, Kojima M, et al. Facilitatory effects of fetuin-A on atherosclerosis. Atherosclerosis. 2016;246:344-51 pubmed publisher
    ..Our results indicate that fetuin-A exerts the stimulatory effects on inflammatory responses in HUVECs, macrophage foam cell formation, and proliferation and collagen production in HASMCs, leading to the development of atherosclerosis. ..
  55. Suchanek P, Králova Lesná I, Poledne R, Lanska V, Hubacek J. An AHSG gene variant modulates basal metabolic rate and body composition development after a short-time lifestyle intervention. Neuro Endocrinol Lett. 2011;32 Suppl 2:32-6 pubmed
    The AHSG (alpha2 Heremans-Schmid glycoprotein) gene is suggested to be important for the regulation of body fat and insulin sensitivity...
  56. Tian W, Li J, Hu S, Peng X, Li G, Liu X, et al. Proteomic identification of alpha-2-HS-glycoprotein as a plasma biomarker of hypopharyngeal squamous cell carcinoma. Int J Clin Exp Pathol. 2015;8:9021-31 pubmed
    ..The up-regulation proteins were alpha-2-HS-glycoprotein (AHSG), complement C4-B, haptoglobin, C-reactive protein, and ceruloplasmin, whereas the down-regulation proteins were ..
  57. Olivier E, Soury E, Ruminy P, Husson A, Parmentier F, Daveau M, et al. Fetuin-B, a second member of the fetuin family in mammals. Biochem J. 2000;350 Pt 2:589-97 pubmed
    ..However, like its fetuin-A counterpart, the fetuin-B mRNA level is down-regulated during the acute phase of experimentally induced inflammation in rat. ..
  58. Kim J, Kim H, Ku S, Kim S, Choi Y, Moon S. Association between human alpha 2-Heremans Schmidt glycoprotein (AHSG) polymorphism and endometriosis in Korean women. Fertil Steril. 2004;82:1497-500 pubmed
    To evaluate the relationship between the alpha 2-Heremans Schmidt glycoprotein (AHSG) gene polymorphism and endometriosis. Case-control study. Department of Obstetrics and Gynecology, Seoul National University Hospital, Korea...
  59. Mukhuty A, Fouzder C, Mukherjee S, Malick C, Mukhopadhyay S, Bhattacharya S, et al. Palmitate induced Fetuin-A secretion from pancreatic ?-cells adversely affects its function and elicits inflammation. Biochem Biophys Res Commun. 2017;491:1118-1124 pubmed publisher
    ..FetA thus creates an inflammatory environment in the pancreatic islets that can become a possible cause behind pancreatic ?-cell dysfunction in chronic hyperlipidemic condition. ..
  60. Ziółkowska H, Wojnar J, Pańczyk Tomaszewska M, Roszkowska Blaim M. [Fetuin A in children with renal diseases]. Przegl Lek. 2006;63 Suppl 3:54-6 pubmed
    b>Fetuin A, 59 kDa protein, produced in the liver is a circulating inhibitor of vascular calcification. The aim of the study was to estimate a concentration of fetuin A in children with renal diseases...
  61. Fourati R, Tedetti M, Guigue C, Goutx M, Zaghden H, Sayadi S, et al. Natural and anthropogenic particulate-bound aliphatic and polycyclic aromatic hydrocarbons in surface waters of the Gulf of Gabès (Tunisia, southern Mediterranean Sea). Environ Sci Pollut Res Int. 2018;25:2476-2494 pubmed publisher
    Particulate-bound aliphatic and polycyclic aromatic hydrocarbons (AHs and PAHs) were investigated in the surface waters of the Gulf of Gabès (Tunisia, southern Mediterranean Sea)...
  62. Chen C, Ye X, Wang Y, Chen Y, Tseng W. Differential Effects of Different Warm-up Protocols on Repeated Sprints-Induced Muscle Damage. J Strength Cond Res. 2017;: pubmed publisher
    ..of running (control); control with single leg slide curl (SLC); and control with active hamstring stretching (AHS)...
  63. Sugars R, Waddington R, Embery G. The interaction of recombinant decorin with alpha2HS-glycoprotein-implications for structural and functional investigations. Protein Expr Purif. 2002;25:180-8 pubmed
  64. Kuzniar J, Porazko T, Klinger M. Relationship between fetuin-A concentration, elevated levels of inflammatory markers, and arterial wall stiffness in end-stage kidney disease. J Ren Nutr. 2008;18:83-6 pubmed
    ..The arterial-stiffening process was unaffected by the Ca x P product, but occurred independent of elevated interleukin-6 levels. ..
  65. Briana D, Boutsikou M, Gourgiotis D, Boutsikou T, Baka S, Marmarinos A, et al. Serum fetuin-A/alpha2-HS-glycoprotein in human pregnancies with normal and restricted fetal growth. J Matern Fetal Neonatal Med. 2008;21:826-30 pubmed publisher
    ..Maternal and fetal fetuin-A concentrations are similar and positively correlated, indicating the likelihood of passive transplacental transfer of this substance. ..
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