AHSG

Summary

Gene Symbol: AHSG
Description: alpha 2-HS glycoprotein
Alias: A2HS, AHS, FETUA, HSGA, alpha-2-HS-glycoprotein, alpha-2-Z-globulin, ba-alpha-2-glycoprotein, fetuin-A
Species: human

Top Publications

  1. doi Dissecting cross-reactivity in hymenoptera venom allergy by circumvention of alpha-1,3-core fucosylation
    Henning Seismann
    Institute of Biochemistry and Molecular Biology, University of Hamburg, Hamburg, Germany
    Mol Immunol 47:799-808. 2010
  2. ncbi Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: a cross-sectional study
    Markus Ketteler
    Department of Nephrology and Immunology, University Hospital Aachen, Aachen, Germany
    Lancet 361:827-33. 2003
  3. pmc Association between human fetuin-A and the metabolic syndrome: data from the Heart and Soul Study
    Joachim H Ix
    Division of Nephrology, Department of Medicine, University of California, San Francisco, CA 94143 0532, USA
    Circulation 113:1760-7. 2006
  4. ncbi Serum fetuin-A levels link inflammation and cardiovascular calcification in hemodialysis patients
    Mario Cozzolino
    Renal Division, S Paolo Hospital, University of Milan, Milan, Italy
    Am J Nephrol 26:423-9. 2006
  5. ncbi Marked defects in the expression and glycosylation of alpha2-HS glycoprotein/fetuin-A in plasma from neonates with intrauterine growth restriction: proteomics screening and potential clinical implications
    Panagiotis M Karamessinis
    Division of Biotechnology and Section of Endocrinology and Metabolism, Biomedical Research Foundation, Academy of Athens, 11527 Athens, Greece
    Mol Cell Proteomics 7:591-9. 2008
  6. doi Serum fetuin-a concentration and endothelial dysfunction in chronic kidney disease
    Kayser Caglar
    Department of Nephrology, Gulhane School of Medicine, Ankara, Turkey
    Nephron Clin Pract 108:c233-40. 2008
  7. pmc Fetuin-A and incident diabetes mellitus in older persons
    Joachim H Ix
    Division of Nephrology and Hypertension, Department of Medicine, University of California, San Diego, and San Diego Veterans Affairs Healthcare System, 3350 La Jolla Village Dr, Mail Code 111 H, San Diego, CA 92161, USA
    JAMA 300:182-8. 2008
  8. pmc Plasma fetuin-A levels and the risk of type 2 diabetes
    Norbert Stefan
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Nephrology, Vascular Disease and Clinical Chemistry, University of Tubingen, Tubingen, Germany
    Diabetes 57:2762-7. 2008
  9. doi Association of AHSG gene polymorphisms with fetuin-A plasma levels and cardiovascular diseases in the EPIC-Potsdam study
    Eva Fisher
    Department of Epidemiology, German Institute of Human Nutrition Potsdam Rehbrucke, Nuthetal, Germany
    Circ Cardiovasc Genet 2:607-13. 2009
  10. doi Serum fetuin A/α2HS-glycoprotein levels in patients with non-alcoholic fatty liver disease: relation with liver fibrosis
    Yusuf Yilmaz
    Department of Gastroenterology, Marmara University School of Medicine, Altunizade, Istanbul
    Ann Clin Biochem 47:549-53. 2010

Research Grants

  1. Lisa Chasan-Taber; Fiscal Year: 2016
  2. NIEHS SUPPORT OF THE AHS COHORT STUDY AT NCI
    Charles Knott; Fiscal Year: 2010
  3. THE AGRICULTURAL HEALTH STUDY - FIELD STATIONS
    Charles Lynch; Fiscal Year: 2010
  4. Sharon M Moe; Fiscal Year: 2015
  5. Determinants and Cardiovascular Consequences of Diabetes in Older Adults
    Susan J Zieman; Fiscal Year: 2012
  6. Longtitudinal Study of Dialysis
    Rulan S Parekh; Fiscal Year: 2012
  7. Musculoskeletal Disorder in Dialysis Patients
    Sharon M Moe; Fiscal Year: 2010
  8. BIOCHEMICAL AND GENETIC MARKERS OF TYPE 2 DIABETES RISK
    Frank B Hu; Fiscal Year: 2013
  9. Role of Fetuin-A in Tumor Cell Growth
    Josiah Ochieng; Fiscal Year: 2012
  10. Pregravid biomarkers of GDM risk, fetal growth and progression to diabetes
    MONIQUE MARIE HEDDERSON; Fiscal Year: 2013

Detail Information

Publications234 found, 100 shown here

  1. doi Dissecting cross-reactivity in hymenoptera venom allergy by circumvention of alpha-1,3-core fucosylation
    Henning Seismann
    Institute of Biochemistry and Molecular Biology, University of Hamburg, Hamburg, Germany
    Mol Immunol 47:799-808. 2010
    ..These findings show that the use of recombinant molecules devoid of CCDs represents a novel strategy with major implications for diagnostic and therapeutic approaches...
  2. ncbi Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: a cross-sectional study
    Markus Ketteler
    Department of Nephrology and Immunology, University Hospital Aachen, Aachen, Germany
    Lancet 361:827-33. 2003
    ..Fetuin-A (alpha2-Heremans Schmid glycoprotein; AHSG) is an important circulating inhibitor of calcification in vivo, and is downregulated during the acute-phase ..
  3. pmc Association between human fetuin-A and the metabolic syndrome: data from the Heart and Soul Study
    Joachim H Ix
    Division of Nephrology, Department of Medicine, University of California, San Francisco, CA 94143 0532, USA
    Circulation 113:1760-7. 2006
    ..We evaluated the association between human serum fetuin-A and the metabolic syndrome (MetS) in a cohort of persons with coronary artery disease...
  4. ncbi Serum fetuin-A levels link inflammation and cardiovascular calcification in hemodialysis patients
    Mario Cozzolino
    Renal Division, S Paolo Hospital, University of Milan, Milan, Italy
    Am J Nephrol 26:423-9. 2006
    ..Fetuin-A is an important inhibitor of CVC. Reduced fetuin-A levels associate with inflammation and increased cardiovascular (CV) mortality in HD. In this study we investigated the association of fetuin-A levels and CVC...
  5. ncbi Marked defects in the expression and glycosylation of alpha2-HS glycoprotein/fetuin-A in plasma from neonates with intrauterine growth restriction: proteomics screening and potential clinical implications
    Panagiotis M Karamessinis
    Division of Biotechnology and Section of Endocrinology and Metabolism, Biomedical Research Foundation, Academy of Athens, 11527 Athens, Greece
    Mol Cell Proteomics 7:591-9. 2008
    ..b>Fetuin A is a glycoprotein that has been associated with promotion of in vitro cell replication, fetal growth and ..
  6. doi Serum fetuin-a concentration and endothelial dysfunction in chronic kidney disease
    Kayser Caglar
    Department of Nephrology, Gulhane School of Medicine, Ankara, Turkey
    Nephron Clin Pract 108:c233-40. 2008
    ..In this study, the investigators hypothesized that fetuin-A, a calcification inhibitor, is a novel risk factor for the development of endothelial dysfunction in patients...
  7. pmc Fetuin-A and incident diabetes mellitus in older persons
    Joachim H Ix
    Division of Nephrology and Hypertension, Department of Medicine, University of California, San Diego, and San Diego Veterans Affairs Healthcare System, 3350 La Jolla Village Dr, Mail Code 111 H, San Diego, CA 92161, USA
    JAMA 300:182-8. 2008
    ..In prior cross-sectional studies in humans, higher fetuin-A levels were associated with insulin resistance. However, the longitudinal association of fetuin-A with incident type 2 diabetes mellitus is unknown...
  8. pmc Plasma fetuin-A levels and the risk of type 2 diabetes
    Norbert Stefan
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Nephrology, Vascular Disease and Clinical Chemistry, University of Tubingen, Tubingen, Germany
    Diabetes 57:2762-7. 2008
    ..We investigated whether plasma fetuin-A levels predict the incidence of type 2 diabetes in a large prospective, population-based study...
  9. doi Association of AHSG gene polymorphisms with fetuin-A plasma levels and cardiovascular diseases in the EPIC-Potsdam study
    Eva Fisher
    Department of Epidemiology, German Institute of Human Nutrition Potsdam Rehbrucke, Nuthetal, Germany
    Circ Cardiovasc Genet 2:607-13. 2009
    ..The goal of our study was to prospectively investigate the potential causal nature of the association between fetuin-A levels and myocardial infarction (MI) and ischemic stroke by applying a Mendelian randomization approach...
  10. doi Serum fetuin A/α2HS-glycoprotein levels in patients with non-alcoholic fatty liver disease: relation with liver fibrosis
    Yusuf Yilmaz
    Department of Gastroenterology, Marmara University School of Medicine, Altunizade, Istanbul
    Ann Clin Biochem 47:549-53. 2010
    Serum concentrations of fetuin A/α2HS-glycoprotein (AHSG) have been linked to human metabolic alterations and can serve as an indicator of liver cell function...
  11. pmc Fetuin-A ({alpha}2HS-glycoprotein) is a major serum adhesive protein that mediates growth signaling in breast tumor cells
    Amos M Sakwe
    Department of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, Tennessee 37208, USA
    J Biol Chem 285:41827-35. 2010
    ..Taken together, our data show the significance of fetuin-A in tumor cell growth mechanisms in vitro and open new research vistas for this protein...
  12. doi Analysis of acute-phase proteins, AHSG, C3, CLI, HP and SAA, reveals distinctive expression patterns associated with breast, colorectal and lung cancer
    Paul Dowling
    National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland
    Int J Cancer 131:911-23. 2012
    ..We have previously demonstrated that levels of alpha-2-heremans-schmid-glycoprotein (AHSG), complement component C3 (C3), clusterin (CLI), haptoglobin (HP) and serum amyloid A (SAA) are significantly ..
  13. pmc Association of fetuin-a with incident diabetes mellitus in community-living older adults: the cardiovascular health study
    Joachim H Ix
    Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, San Diego VA Healthcare System, San Diego, CA 92161, USA
    Circulation 125:2316-22. 2012
    ..We sought to confirm the association of fetuin-A with incident diabetes mellitus in older persons and to determine whether the association differs by age, sex, and race and among persons with cardiovascular disease (CVD)...
  14. doi Endoplasmic reticulum stress induces the expression of fetuin-A to develop insulin resistance
    Horng Yih Ou
    Department of Internal Medicine, National Cheng Kung University Hospital, 138, Sheng Li Road, Tainan 70403, Taiwan
    Endocrinology 153:2974-84. 2012
    ..Moreover, ER stress induced by high glucose and palmitate increased the expression of fetuin-A and further contributed to the development of insulin resistance...
  15. pmc Cardiometabolic correlates and heritability of fetuin-A, retinol-binding protein 4, and fatty-acid binding protein 4 in the Framingham Heart Study
    Bernhard M Kaess
    National Heart, Blood, and Lung Institute s Framingham Heart Study, Framingham, MA 01702, USA
    J Clin Endocrinol Metab 97:E1943-7. 2012
    ..Fetuin-A, retinol-binding protein 4 (RBP4), and fatty-acid binding protein 4 (FABP4) are novel biomarkers that may link adiposity to insulin resistance and the metabolic syndrome (MetSyn)...
  16. pmc Phosphorylation of human plasma alpha2-Heremans-Schmid glycoprotein (human fetuin) in vivo
    A C Haglund
    Department of Medical Biochemistry and Microbiology, Biomedical Centre, University of Uppsala, Box 582, SE 751 23 Uppsala, Sweden
    Biochem J 357:437-45. 2001
    ....
  17. ncbi Structural basis of calcification inhibition by alpha 2-HS glycoprotein/fetuin-A. Formation of colloidal calciprotein particles
    Alexander Heiss
    IZKF BIOMAT, University Clinics, RWTH Aachen, Pauwelsstrasse 30, D 52074 Aachen, Germany
    J Biol Chem 278:13333-41. 2003
    Genetic evidence from mutant mice suggests that alpha(2)-HS glycoprotein/fetuin-A (Ahsg) is a systemic inhibitor of precipitation of basic calcium phosphate preventing unwanted calcification...
  18. ncbi Low fetuin-A levels are associated with cardiovascular death: Impact of variations in the gene encoding fetuin
    Peter Stenvinkel
    Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Karolinska University Hospital, Stockholm, Sweden
    Kidney Int 67:2383-92. 2005
    ..In the present study, we evaluated the association between fetuin-A, clinical phenotype, and outcome, as well as the impact of fetuin gene (AHSG) polymorphisms on the protein product and outcome.
  19. pmc Fetuin-A induces cytokine expression and suppresses adiponectin production
    Anita M Hennige
    Department of Internal Medicine, Division of Endocrinology, Nephrology, Vascular Disease and Clinical Chemistry, University of Tubingen, Tubingen, Germany
    PLoS ONE 3:e1765. 2008
    The secreted liver protein fetuin-A (AHSG) is up-regulated in hepatic steatosis and the metabolic syndrome. These states are strongly associated with low-grade inflammation and hypoadiponectinemia...
  20. doi Is fetuin-A/alpha2-Heremans-Schmid glycoprotein associated with the metabolic syndrome in patients with chronic kidney disease?
    Jonas Axelsson
    Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    Am J Nephrol 28:669-76. 2008
    ..We hypothesized that the circulating calcification inhibitor fetuin-A/AHSG, which is also a natural inhibitor of the tyrosine kinase insulin receptor, could be one factor explaining the ..
  21. doi Fetuin-A and its relation to metabolic syndrome and fatty liver disease in obese children before and after weight loss
    Thomas Reinehr
    Department of Pediatric Nutrition Medicine, Vestische Hospital for Children and Adolescents Datteln, University of Witten Herdecke, Dr F Steiner Str 5, D 45711 Datteln, Germany
    J Clin Endocrinol Metab 93:4479-85. 2008
    ..There are very limited data available concerning the relationships between fetuin-A, weight status, nonalcoholic fatty liver disease (NAFLD), and features of the metabolic syndrome (MetS) in obese humans, and especially in children...
  22. doi Plasma fetuin-a levels and the risk of myocardial infarction and ischemic stroke
    Cornelia Weikert
    Department of Epidemiology, German Institute of Human Nutrition, Nuthetal, Germany
    Circulation 118:2555-62. 2008
    ..Circulating fetuin-A levels are elevated in humans with metabolic syndrome and insulin resistance, conditions that are associated with increased risk of cardiovascular disease...
  23. doi Increased aortic wall stiffness associated with low circulating fetuin A and high C-reactive protein in predialysis patients
    Tomasz Porazko
    Department of Nephrology and Transplantation Medicine, Wrocław Medical University, Wrocław, Poland
    Nephron Clin Pract 113:c81-7. 2009
    ..The aim of the study was to analyze relationships between inflammatory markers, fetuin A and arterial wall stiffness in CKD patients in the predialysis period and on maintenance dialysis.
  24. pmc Mechanisms linking obesity, chronic kidney disease, and fatty liver disease: the roles of fetuin-A, adiponectin, and AMPK
    Joachim H Ix
    Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego Veterans Affairs San Diego Healthcare System, CA 92093 0711, USA
    J Am Soc Nephrol 21:406-12. 2010
    ..Regulation of these early upstream pathways may provide new therapeutic targets for these increasingly common sequelae of obesity...
  25. doi Association of fetuin-A and cardiac calcification and inflammation levels in hemodialysis patients
    Amal M El-Shehaby
    Department of Medical Biochemistry, Faculty of Medicine, Cairo University, Cairo, Egypt
    Scand J Clin Lab Invest 70:575-82. 2010
    ....
  26. doi Fetuin-A regulation of calcified matrix metabolism
    Willi Jahnen-Dechent
    RWTH Aachen University Clinics, Pauwelsstrasse 30, 52074 Aachen, Germany
    Circ Res 108:1494-509. 2011
    ..Fetuin-A deficiency is associated with soft tissue calcification in mice and humans...
  27. doi Fetuin A in nonalcoholic fatty liver disease: in vivo and in vitro studies
    John Willy Haukeland
    Department of Gastroenterology Research Institute for Internal Medicine, Oslo University Hospital Ulleval, PB 4950, 0424 Oslo, Norway
    Eur J Endocrinol 166:503-10. 2012
    b>Fetuin A has been associated with insulin resistance and the metabolic syndrome. We therefore explored the role of fetuin A in nonalcoholic fatty liver disease (NAFLD).
  28. pmc Jacalin bound plasma O-glycoproteome and reduced sialylation of alpha 2-HS glycoprotein (A2HSG) in rheumatoid arthritis patients
    Ashish Saroha
    Genomics and Molecular Medicine Division, CSIR Institute of Genomics and Integrative Biology, Delhi, India
    PLoS ONE 7:e46374. 2012
    ..Altered glycoprotein expression and functional as well as structural studies of glycans might help in the diagnosis of RA and understanding the disease pathogenesis...
  29. pmc Human alpha 2-HS-glycoprotein: the A and B chains with a connecting sequence are encoded by a single mRNA transcript
    C C Lee
    Proc Natl Acad Sci U S A 84:4403-7. 1987
    The alpha 2-HS-glycoprotein (AHSG) is a plasma protein reported to play roles in bone mineralization and in the immune response. It is composed of two subunits, the A and B chains...
  30. ncbi Serum alpha 2-HS-glycoprotein is an inhibitor of the human insulin receptor at the tyrosine kinase level
    P R Srinivas
    Center for Molecular Biology, Wayne State University, Detroit, Michigan 48201
    Mol Endocrinol 7:1445-55. 1993
    ..DNA sequence analysis reveals identity with the mRNA product of a human gene AHSG encoding a serum protein, alpha 2-Heremans Scmid-glycoprotein (alpha 2HSG), with heretofore unknown physiological ..
  31. ncbi Molecular evidence for human alpha 2-HS glycoprotein (AHSG) polymorphism
    M Osawa
    Tokai University School of Medicine, Department of Forensic Medicine, Kanagawa, Japan
    Hum Genet 99:18-21. 1997
    Alpha 2-HS glycoprotein (AHSG) is a human plasma glycoprotein that exhibits genetic polymorphism on isoelectric focusing (IEF). To identify the origin of two common alleles, AHSG*1 and *2, we examined nucleotide exchanges in the gene...
  32. ncbi Fetuin/alpha2-HS glycoprotein enhances phagocytosis of apoptotic cells and macropinocytosis by human macrophages
    Hubertus P A Jersmann
    MRC Centre for Inflammation Research, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, UK
    Clin Sci (Lond) 105:273-8. 2003
    ..Fetuin also substantially increased the uptake of labelled dextran 70000 by macrophages, which occurs by macropinocytosis, suggesting that this may be one of the mechanisms utilized for apoptotic cell uptake...
  33. ncbi Association of alpha2-HS glycoprotein (AHSG, fetuin-A) polymorphism with AHSG and phosphate serum levels
    Motoki Osawa
    Department of Experimental and Forensic Pathology, Faculty of Medicine, Yamagata University, 2 2 2 Iida nishi, Yamagata, 990 9585, Japan
    Hum Genet 116:146-51. 2005
    Alpha2-HS glycoprotein (AHSG), also known as fetuin-A, is a plasma protein displaying high-affinity interaction with calcium phosphate, by which ectopic vascular calcification is prevented...
  34. ncbi Fetuin-A and extraosseous calcification in uremia
    Markus Ketteler
    Department of Nephrology and Clinical Immunology, University Hospital Aachen, Germany
    Curr Opin Nephrol Hypertens 14:337-42. 2005
    ..The emerging role of fetuin-A deficiency as a risk factor in dialysis patients was documented in a cross-sectional study demonstrating a significant correlation with all-cause and cardiovascular mortality...
  35. ncbi A synonymous coding polymorphism in the alpha2-Heremans-schmid glycoprotein gene is associated with type 2 diabetes in French Caucasians
    Afshan Siddiq
    Section of Genomic Medicine, 2nd Floor, 233 L Block, Imperial College, Hammersmith Campus, Du Cane Rd, London, W12 0NN UK
    Diabetes 54:2477-81. 2005
    alpha2-Heremans-Schmid glycoprotein (AHSG) is an abundant plasma protein synthesized predominantly in the liver. The AHSG gene, consisting of seven exons and spanning 8...
  36. ncbi Association of high alpha2-Heremans-Schmid glycoprotein/fetuin concentration in serum and intima-media thickness in patients with atherosclerotic vascular disease and low bone mass
    Carmelo E Fiore
    Department of Internal Medicine, University of Catania O V E, Catania, Italy
    Atherosclerosis 195:110-5. 2007
    Alpha2-Heremans-Schmid glycoprotein (AHSG; fetuin), a member of the cystatin superfamily of cysteine protease inhibitors involved in vascular pathology and bone metabolism, has been reported to be reduced in patients with atherosclerosis ..
  37. ncbi Endothelial dysfunction and fetuin A levels before and after kidney transplantation
    Kayser Caglar
    Department of Nephrology, Gulhane School of Medicine, Ankara, Turkey
    Transplantation 83:392-7. 2007
    ..Endothelial dysfunction (ED) has a major role in the cardiovascular outcome of patients with chronic kidney disease (CKD). The aim of this study was to investigate the relation between fetuin A levels and ED in kidney transplant recipients.
  38. ncbi Systemic and local levels of fetuin-A in calcific aortic valve stenosis
    Jens J Kaden
    First Department of Medicine, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    Int J Mol Med 20:193-7. 2007
    ....
  39. ncbi A promoter polymorphism of the alpha2-HS glycoprotein gene is associated with its transcriptional activity
    Mari Inoue
    Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Kohasu, Oko cho, Nankoku, Kochi 783 8505, Japan
    Diabetes Res Clin Pract 79:164-70. 2008
    alpha2-Heremans Schmid glycoprotein (AHSG), also designated fetuin-A, is an abundant plasma protein that is expressed in hepatocytes...
  40. ncbi Evaluation of serum fetuin-A relationships with biochemical parameters in patients on hemodialysis
    Osamu Oikawa
    Division of Nephrology and Endocrinology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
    Clin Exp Nephrol 11:304-8. 2007
    ..In this study, the relation between serum fetuin-A concentration and biochemical parameters in patients on hemodialysis was investigated...
  41. doi AHSG tag single nucleotide polymorphisms associate with type 2 diabetes and dyslipidemia: studies of metabolic traits in 7,683 white Danish subjects
    Gitte Andersen
    Steno Diabetes Center, Niels Steensens Vej 1, NLC2 12, DK 2820 Gentofte, Denmark
    Diabetes 57:1427-32. 2008
    The gene encoding the alpha2 Heremans-Schmid glycoprotein (AHSG) is a credible biological and positional candidate gene for type 2 diabetes and the metabolic syndrome, and previous attempts to relate AHSG variation with type 2 diabetes ..
  42. doi Fetuin-A and arterial stiffness in patients with normal kidney function
    Marcel Roos
    Department of Nephrology, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Regul Pept 154:39-43. 2009
    To evaluate the association between fetuin-A level (AHSG), its encoding gene (Thr256Ser) and arterial function in subjects with normal kidney function.
  43. pmc Association of lower plasma fetuin-a levels with peripheral arterial disease in type 2 diabetes
    Luis H Eraso
    Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Diabetes Care 33:408-10. 2010
    ..Fetuin-A is an inhibitor of vascular calcification and a mediator of insulin resistance. This study evaluated the association of plasma fetuin-A and peripheral arterial disease (PAD)...
  44. doi Fetuin-A and atherosclerotic calcified plaque in patients with type 2 diabetes mellitus
    Masanori Emoto
    The Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    Metabolism 59:873-8. 2010
    ..753; 95% confidence interval, 0.608-0.933; P = .010). These results suggest that fetuin-A may inhibit the calcification of atherosclerotic plaques independently of the dialyzed condition...
  45. pmc Plasma fetuin-A concentrations in young and older high- and low-active men
    Nathan T Jenkins
    Department of Kinesiology, School of Public Health, University of Maryland College Park, MD 20742, USA
    Metabolism 60:265-71. 2011
    ..Therefore, the maintenance of low levels of circulating fetuin-A may be a novel mechanism contributing to enhanced insulin sensitivity with regular physical activity...
  46. ncbi Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation
    Gretchen A Murphy
    Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599 7295, USA
    J Biol Chem 277:9966-75. 2002
    ..Finally, unlike Ras, TC21 did not activate the Rac small GTPase, indicating that Ras may not activate Rac by PI3K. Taken together, these results suggest that PI3K, but not RalGDS, is an important mediator of cell proliferation by TC21...
  47. ncbi alpha2-Heremans-Schmid glycoprotein gene polymorphisms are associated with adipocyte insulin action
    I Dahlman
    Department of Medicine M61, Karolinska University Hospital, Huddinge, Karolinska Institute, 141 86 Stockholm, Sweden
    Diabetologia 47:1974-9. 2004
    The aim of this study was to investigate the effect of single-nucleotide polymorphisms (SNPs) in the gene encoding the human alpha(2)-Heremans-Schmid glycoprotein (AHSG) on obesity and insulin action in adipocytes.
  48. doi Age-dependent inhibition of ectopic calcification: a possible role for fetuin-A and osteopontin in patients with juvenile dermatomyositis with calcinosis
    G Marhaug
    Department of Paediatrics, Trondheim University Hospital
    Rheumatology (Oxford) 47:1031-7. 2008
    ....
  49. ncbi Fetuin: an acute phase protein in cattle
    K M Dziegielewska
    Clinical Neurological Sciences Developmental Group, Southampton General Hospital, England
    J Comp Physiol B 162:168-71. 1992
    ..A significant negative correlation between the concentrations of fetuin and albumin has also been found. Thus, fetuin appears to be a positive acute phase protein in cattle...
  50. ncbi Renal osteodystrophy: alpha-Heremans Schmid glycoprotein/fetuin-A, matrix GLA protein serum levels, and bone histomorphometry
    Giorgio Coen
    Ospedale Israelitico, Rome, Italy
    Am J Kidney Dis 48:106-13. 2006
    ..The aim of this study is to evaluate whether serum fetuin-A and MGP are influenced by type of renal osteodystrophy, they correlate with bone histomorphometric and histodynamic parameters, and/or serum levels may influence bone turnover...
  51. doi Fetuin-A and interleukin-18 levels in ankylosing spondylitis
    Ismail Sari
    Department of Internal Medicine, Izmir Bozyaka Training and Research Hospital, Izmir, Turkey
    Int J Rheum Dis 13:75-81. 2010
    ..Preliminary evidence suggests that ankylosing spondylitis (AS) is associated with an increased risk of atherosclerosis. The aim of the present study was to investigate possible abnormalities in IL-18 and fetuin-A levels in AS...
  52. ncbi Proteolytic processing by matrix metalloproteinases and phosphorylation by protein kinase CK2 of fetuin-A, the major globulin of fetal calf serum
    Dieter Kübler
    Mechanisms of Biomolecular Interactions A060, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Biochimie 89:410-8. 2007
    ....
  53. doi Fetuin-A and cystatin C are endogenous inhibitors of human meprin metalloproteases
    Jana Hedrich
    Institute of Zoology, Cell and Matrix Biology, Johannes Gutenberg University, Johannes von Müller Weg 6, 55128 Mainz, Germany
    Biochemistry 49:8599-607. 2010
    ..5 × 10(-6) M) but, interestingly, not for meprin β. Thus, the identification of fetuin-A and cystatin C as endogenous proteolytic regulators of meprin activity broadens our understanding of the proteolytic network in plasma...
  54. ncbi Study on the relationship of serum fetuin-A concentration with aortic stiffness in patients on dialysis
    Marc M H Hermans
    Department of Internal Medicine and Nephrology, Academic Hospital Maastricht, PO Box 5800, 6202 AZ, Maastricht, The Netherlands
    Nephrol Dial Transplant 21:1293-9. 2006
    ..In this study, the relation between serum fetuin-A concentration and parameters of aortic stiffness was investigated in patients with end-stage renal disease...
  55. doi Extended-release niacin decreases serum fetuin-A concentrations in individuals with metabolic syndrome
    Shalini V Kaushik
    Department of Nutrition and Food Science, Auburn University, Auburn, AL 36849, USA
    Diabetes Metab Res Rev 25:427-34. 2009
    ....
  56. ncbi The serum glycoprotein fetuin-A promotes Lewis lung carcinoma tumorigenesis via adhesive-dependent and adhesive-independent mechanisms
    Madappa N Kundranda
    Department of Biochemistry, Meharry Medical College, Nashville, TN 37208, USA
    Cancer Res 65:499-506. 2005
    ..These studies support the role of fetuin-A as a major growth promoter in serum that can influence tumor establishment and growth...
  57. pmc Fetuin-mineral complex reflects extraosseous calcification stress in CKD
    Takayuki Hamano
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Am Soc Nephrol 21:1998-2007. 2010
    ..These data suggest that a quantitative measure of FMC, not supernatant or serum fetuin-A as measured in previous studies, reflects extraosseous calcification stress...
  58. doi Fetuin-A serum levels in patients with aortic aneurysms of Marfan syndrome and atherosclerosis
    Zoltán Szeberin
    Department of Vascular Surgery, Semmelweis University, Budapest, Hungary
    Eur J Clin Invest 41:176-82. 2011
    ..The aim of our study was to investigate the association of serum fetuin-A levels with aortic aneurysms of different aetiology: Marfan syndrome and atherosclerosis...
  59. ncbi Fetuin-A uptake in bovine vascular smooth muscle cells is calcium dependent and mediated by annexins
    Neal X Chen
    Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Physiol Renal Physiol 292:F599-606. 2007
    ..This regulated uptake may be a mechanism by which fetuin-A inhibits VSMC calcification in the presence of excess calcium...
  60. ncbi Fetuin A stabilizes m-calpain and facilitates plasma membrane repair
    Ronald L Mellgren
    Department of Physiology and Pharmacology, University of Toledo College of Medicine, Toledo, Ohio 43614, USA
    J Biol Chem 282:35868-77. 2007
    Yeast two-hybrid experiments identified alpha(2)-Heremans-Schmid glycoprotein (human fetuin A) as a binding partner for calpain domain III (DIII)...
  61. doi Serum fetuin a in hemodialysis: a link between derangement of calcium-phosphorus homeostasis and progression of atherosclerosis?
    Giovanni Pertosa
    Nephrology, Dialysis, and Transplantation Unit, University of Bari, Bari, Italy
    Am J Kidney Dis 53:467-74. 2009
    b>Fetuin A, a circulating inhibitor of ectopic calcification, is downregulated in hemodialysis and has been shown to predict cardiovascular mortality in this setting...
  62. pmc Overexpression of fetuin-a counteracts ectopic mineralization in a mouse model of pseudoxanthoma elasticum (abcc6(-/-))
    Qiujie Jiang
    Department of Dermatology and Cutaneous Biology, Jefferson Medical College, and Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    J Invest Dermatol 130:1288-96. 2010
    ..Observations in targeted mutant mice (Ahsg(-/-)) and in cell culture model systems have shown that fetuin-A is a powerful anti-mineralization factor in ..
  63. pmc Tissue distribution and activity testing suggest a similar but not identical function of fetuin-B and fetuin-A
    Bernd Denecke
    Interdisciplinary Center for Clinical Research on Biomaterials IZKF BIOMAT, University Hospital, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Biochem J 376:135-45. 2003
    ..Therefore fetuin-B may have a function that is partly overlapping, if not identical, with the function of fetuin-A...
  64. ncbi Serum fetuin-A in nondialyzed patients with diabetic nephropathy: relationship with coronary artery calcification
    Rajnish Mehrotra
    Division of Nephrology and Hypertension, Harbor UCLA Medical Center, Torrance, California 90502, USA
    Kidney Int 67:1070-7. 2005
    ..Fetuin-A is the most potent circulating inhibitor of calcium phosphorus precipitation and, possibly, an important mediator of insulin resistance...
  65. ncbi Associations of serum fetuin-A with malnutrition, inflammation, atherosclerosis and valvular calcification syndrome and outcome in peritoneal dialysis patients
    Angela Yee Moon Wang
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Nephrol Dial Transplant 20:1676-85. 2005
    ..However, its relationships with cardiac valvular calcification and atherosclerosis and outcome have not been evaluated in peritoneal dialysis (PD) patients...
  66. pmc Fetuin-A and kidney function in persons with coronary artery disease--data from the Heart and Soul Study
    Joachim H Ix
    Division of Nephrology, Department of Medicine, Box 0532, HSE 672, University of California, San Francisco, San Francisco, CA 94143 0532, USA
    Nephrol Dial Transplant 21:2144-51. 2006
    ..Whether fetuin-A concentrations are also lower in the setting of mild-to-moderate chronic kidney disease (CKD) is unknown...
  67. ncbi Association of serum fetuin-A with carotid arterial stiffness
    Katsuhito Mori
    Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    Clin Endocrinol (Oxf) 66:246-50. 2007
    ..The objective of this study was to investigate the association between serum fetuin-A levels and arterial stiffness, a functional property of atherosclerosis, in healthy subjects...
  68. pmc Association of fetuin-A with mitral annular calcification and aortic stenosis among persons with coronary heart disease: data from the Heart and Soul Study
    Joachim H Ix
    Division of Nephrology, Department of Medicine, Box 0532, HSE 672, University of California, San Francisco, San Francisco, CA 94143 0532, USA
    Circulation 115:2533-9. 2007
    ..Lower serum fetuin-A concentrations are associated with valvular calcification in persons with end-stage renal disease. Whether fetuin-A is associated with valvular calcification in other patient populations is unknown...
  69. doi Urine fetuin-A values in relation to the presence of urolithiasis
    David Stejskal
    Department of Laboratory Medicine, Sternbek Hospital, Sternberk, Czech Republic
    BJU Int 101:1151-4. 2008
    ....
  70. doi The circulating calcification inhibitors, fetuin-A and osteoprotegerin, but not matrix Gla protein, are associated with vascular stiffness and calcification in children on dialysis
    Rukshana C Shroff
    Nephrourology Unit, Great Ormond Street Hospital and UCL Institute of Child Health, London WC1N 1EH, UK
    Nephrol Dial Transplant 23:3263-71. 2008
    ....
  71. doi Effects of pioglitazone on serum fetuin-A levels in patients with type 2 diabetes mellitus
    Katsuhito Mori
    Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    Metabolism 57:1248-52. 2008
    ..9 microg/mL, P = .006), whereas there were no changes in serum fetuin-A after intervention in either the Met or the Ex groups. We hypothesize that pioglitazone could partially ameliorate insulin resistance via modulating fetuin-A levels...
  72. doi Low serum fetuin-A concentration predicts poor outcome only in the presence of inflammation in prevalent haemodialysis patients
    G Metry
    Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Eur J Clin Invest 38:804-11. 2008
    ..Chronic inflammation, which is common in CKD, may promote vascular calcification...
  73. pmc Fetuin-A protects against atherosclerotic calcification in CKD
    Ralf Westenfeld
    Department of Nephrology, Rheinisch Westfälische Technische Hochschule RWTH Aachen University Hospital, Aachen, Germany
    J Am Soc Nephrol 20:1264-74. 2009
    ..In conclusion, fetuin-A inhibits pathologic calcification in both the soft tissue and vasculature, even in the setting of atherosclerosis...
  74. doi The physiologic development of fetuin-a serum concentrations in children
    Martin Hausler
    Department of Pediatrics, RWTH Aachen University Hospital, Pauwelsstrasse 30, Aachen 52074, Germany
    Pediatr Res 66:660-4. 2009
    ..This might point to a new mechanism contributing to organ damage in these patients, comparable with children on dialysis...
  75. doi Fetuin-A and CD40 L plasma levels in acute ischemic stroke: differences in relation to TOAST subtype and correlation with clinical and laboratory variables
    A Tuttolomondo
    Dipartimento Biomedico di Medicina Interna e Specialistica, Universita degli Studi di Palermo, Piazza delle Cliniche n 2, Palermo, Italy
    Atherosclerosis 208:290-6. 2010
    ....
  76. pmc Fetuin-A and change in body composition in older persons
    Joachim H Ix
    Division of Nephrology, Department of Medicine, and Division of Preventive Medicine, University of California San Diego, Veterans Affairs San Diego Healthcare System, San Diego, California 92161, USA
    J Clin Endocrinol Metab 94:4492-8. 2009
    ..Whether higher fetuin-A concentrations are associated with accumulation of adiposity over time is unknown...
  77. pmc Fetuin-A/albumin-mineral complexes resembling serum calcium granules and putative nanobacteria: demonstration of a dual inhibition-seeding concept
    Cheng Yeu Wu
    Laboratory of Nanomaterials, Chang Gung University, Gueishan, Taiwan, Republic of China
    PLoS ONE 4:e8058. 2009
    ....
  78. doi Fetuin-A is an independent determinant of change of aortic stiffness over 1 year in non-diabetic patients with CKD stages 3 and 4
    Martin L Ford
    Brighton and Sussex Medical School, Audrey Emerton Building, Eastern Road, Brighton, BN2 5BE, UK
    Nephrol Dial Transplant 25:1853-8. 2010
    ..We tested the relationship between fetuin-A and change in arterial stiffness in CKD stages 3 and 4...
  79. doi NF-kappaB mediates lipid-induced fetuin-A expression in hepatocytes that impairs adipocyte function effecting insulin resistance
    Suman Dasgupta
    Department of Zoology, Visva Bharati, A Central University, Santiniketan, India
    Biochem J 429:451-62. 2010
    ..Our results reveal a new dimension of lipid-induced insulin resistance and open another contemporary target for therapeutic intervention in Type 2 diabetes...
  80. ncbi [Low serum fetuin A is a risk factor of coronary artery calcification in patients starting hemodialysis]
    Bin Zhang
    Department of Nephrology, Guangdong General Hospital, Guangzhou 510080, China
    Nan Fang Yi Ke Da Xue Xue Bao 30:1002-4. 2010
    To examine the relationship between reduction of serum fetuin A and coronary artery calcification (CAC) in patients starting hemodialysis.
  81. doi Serum fetuin-A, cardiovascular risk factors, and six-year follow-up outcome in patients with coronary heart disease
    Marcel Roos
    Department of Nephrology, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Am J Cardiol 105:1666-72. 2010
    ..Measurement of serum fetuin-A levels may not emerge as a valuable tool for evaluating future CVD risk in patients aggressively treated for advanced atherosclerosis...
  82. pmc Fetuin-A is a mineral carrier protein: small angle neutron scattering provides new insight on Fetuin-A controlled calcification inhibition
    Alexander Heiss
    Institute of Solid State Research, Helmholtz Research Center Jülich, Julich, Germany
    Biophys J 99:3986-95. 2010
    ..Hence, our experiments revealed a second mechanism of long-term mineral ion stabilization by the fetuin-A that is complementary to the formation of CPPs...
  83. ncbi Fetuin-null mice are protected against obesity and insulin resistance associated with aging
    Suresh T Mathews
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Biochem Biophys Res Commun 350:437-43. 2006
    alpha2-HS glycoprotein (AHSG), also known as fetuin-A, inhibits insulin receptor autophosphorylation and tyrosine kinase activity in vitro and in vivo...
  84. doi Fully phosphorylated fetuin-A forms a mineral complex in the serum of rats with adenine-induced renal failure
    Isao Matsui
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan
    Kidney Int 75:915-28. 2009
    ..Our results suggest that the measurement of serum fetuin-mineral complex rather than fetuin-A alone might provide a better indication of extra-osseous calcification propensity...
  85. ncbi Improved insulin sensitivity and resistance to weight gain in mice null for the Ahsg gene
    Suresh T Mathews
    Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Diabetes 51:2450-8. 2002
    ..The fetuin gene (AHSG) is located on human chromosome 3q27, recently identified as a susceptibility locus for type 2 diabetes and the ..
  86. doi Serum fetuin--a concentrations are inversely related to cytokine concentrations in patients with chronic renal failure
    Erkan Dervisoglu
    Department of Nephrology, Kocaeli University School of Medicine, Kocaeli, Turkey
    Cytokine 44:323-7. 2008
    ..To understand these relationships, we investigated the relationship between serum fetuin-A and proinflammatory cytokine levels in patients with chronic renal failure (CRF)...
  87. doi Effects of bone and mineral metabolism on arterial elasticity in chronic renal failure
    Eva Kis
    First Department of Pediatrics, Semmelweis University, Budapest Bókay János u 53 54, 1083, Hungary
    Pediatr Nephrol 24:2413-20. 2009
    ..It might explain the connection between disturbed mineral and bone metabolism and Ast. Tx might be beneficial on Ast, though follow-up studies are needed...
  88. ncbi Human recombinant alpha 2-HS glycoprotein is produced in insect cells as a full length inhibitor of the insulin receptor tyrosine kinase
    L Kalabay
    3rd Department of Medicine, Semmelweis University Medical School, Budapest, Hungary
    Horm Metab Res 30:1-6. 1998
    Human Alpha 2-HS glycoprotein (AHSG), a glycoprotein synthesized by hepatocytes, was expressed in insect cells using the recombinant baculovirus system...
  89. doi Patch testing for the diagnosis of anticonvulsant hypersensitivity syndrome: a systematic review
    Abdelbaset A Elzagallaai
    Ivey Chair in Molecular Toxicology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    Drug Saf 32:391-408. 2009
    Anticonvulsant hypersensitivity syndrome (AHS), also known by the other names drug rash (reaction) with eosinophilia and systemic symptoms (DRESS) and drug-induced hypersensitivity syndrome (DIHS), is a rare and potentially fatal ..
  90. pmc Laparoscopy-assisted vaginal hysterectomy compared with abdominal hysterectomy
    J Garcia-Padial
    Department of Obstetrics and Gynecology, Creighton University, Omaha, Nebraska, USA
    J Natl Med Assoc 87:288-90. 1995
    ..Council Bluffs, Iowa and at St Joseph Hospital, Omaha, Nebraska were compared with 194 abdominal hysterectomies (AHs) for benign or noninvasive disease...
  91. pmc Coumaphos exposure and incident cancer among male participants in the Agricultural Health Study (AHS)
    Carol H Christensen
    Toxicology and Epidemiology Branch, Health Effects Division, Office of Pesticide Programs, U S Environmental Protection Agency, Washington, DC, USA
    Environ Health Perspect 118:92-6. 2010
    Coumaphos is an organophosphate livestock insecticide. Previous research in the Agricultural Health Study (AHS) cohort observed a positive association between coumaphos and prostate cancer in men with a family history of prostate cancer.
  92. ncbi Comparison of farmers in the agricultural health study to the 1992 and the 1997 censuses of agriculture
    Charles F Lynch
    Department of Epidemiology, University of Iowa College of Public Health, Iowa City, IA 52242, USA
    J Agromedicine 10:13-22. 2005
    The Agricultural Health Study (AHS) is a large, prospective cohort study in the states of Iowa and North Carolina that has been developed to better understand how pesticides and other agricultural exposures relate to the occurrence of ..
  93. ncbi Analysis of hepatitis A virus protein 2B in sera of hepatitis A of various severities
    Keiichi Fujiwara
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    J Gastroenterol 42:560-6. 2007
    ..We therefore analyzed HAV 2B from many patients with various clinical disease severities...
  94. ncbi The spatial and seasonal distribution of African horse sickness and its potential Culicoides vectors in Morocco
    M Baylis
    Institute for Animal Health, Pirbright, U K
    Med Vet Entomol 11:203-12. 1997
    African horse sickness (AHS) is a vector-borne, infectious disease of equines that is caused by African horse sickness virus (AHSV). The only proven field vector is the biting midge Culicoides imicola, although C. obsoletus and C...
  95. ncbi Serum levels of several organochlorine pesticides in farmers correspond with dietary exposure and local use history
    J W Brock
    National Center for Environmental Health NCEH, Centers for Disease Control, Atlanta, GA 30341, USA
    Toxicol Ind Health 14:275-89. 1998
    In response to reported increased cancer risks among farmers, the Agricultural Health Study (AHS) was designed to examine health outcomes and environmental exposures among farm families in the United States...
  96. doi Accelerated evolution of Fetuin-A (FETUA, also AHSG) is driven by positive Darwinian selection, not GC-biased gene conversion
    Yvonne Döring
    Institute for Molecular Cardiovascular Research, University Hospital Aachen, 52074 Aachen, Germany
    Gene 463:49-55. 2010
    Human Fetuin-A (FETUA, also termed AHSG) is a serum protein composed of two cystatin-like domains D1 and D2 of together 235 amino acids (aa) and an unrelated domain D3 of 114 aa...
  97. ncbi Molecular detection of Culicoides spp. and Culicoides imicola, the principal vector of bluetongue (BT) and African horse sickness (AHS) in Africa and Europe
    Catherine Cêtre-Sossah
    CIRAD EMVT, Campus International de Baillarguet, TA30 G, 34398 Montpellier Cedex 5, France
    Vet Res 35:325-37. 2004
    Bluetongue (BT) and African Horse Sickness (AHS) are infectious arthropod-borne viral diseases affecting ruminants and horses, respectively...
  98. ncbi African horse sickness in Spain
    M Rodriguez
    Departamento de Patologia Animal II, Facultad de Veterinaria, Universidad Complutense, Madrid, Spain
    Vet Microbiol 33:129-42. 1992
    The aetiology, pathogenesis and epizootiology of African horse sickness (AHS) are reviewed with special reference to recent outbreaks in the Iberian peninsula. AHS is a highly fatal insect-borne viral disease of Equidae...
  99. ncbi Control and eradication of African horse sickness with vaccine
    J M Sanchez-Vizcaino
    Facultad de Veterinaria, Universidad Complutense, Madrid, Spain
    Dev Biol (Basel) 119:255-8. 2004
    African horse sickness (AHS) is an infectious but no-contagious viral disease of equidae with high mortality in horses...
  100. ncbi Strabismus after deep lateral wall orbital decompression in thyroid-related orbitopathy patients using automated hess screen
    Guy J Ben Simon
    Jules Stein Eye Institute and Department of Ophthalmology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California, USA
    Ophthalmology 113:1050-5. 2006
    To evaluate the effect of deep lateral wall orbital decompression with intraconal fat debulking on strabismus in thyroid-related orbitopathy (TRO) patients using automated Hess screen (AHS).

Research Grants74

  1. Lisa Chasan-Taber; Fiscal Year: 2016
    ..e., blood lipids, blood pressure, CRP, fetuin A, albumin-to-creatinine ratio), and 4) the adoption and maintenance of postpartum behaviors associated with weight ..
  2. NIEHS SUPPORT OF THE AHS COHORT STUDY AT NCI
    Charles Knott; Fiscal Year: 2010
    The Agricultural Health Study (AHS) is a major effort which is designed to evaluate the relationship between pesticides and other agricultural factors and the risk of cancer and other diseases...
  3. THE AGRICULTURAL HEALTH STUDY - FIELD STATIONS
    Charles Lynch; Fiscal Year: 2010
    The Agricultural Health Study (AHS) is a major effort which is designed to evaluate the relationship between pesticides and other agricultural factors and the risk of cancer and other diseases...
  4. Sharon M Moe; Fiscal Year: 2015
    ..abstract_text> ..
  5. Determinants and Cardiovascular Consequences of Diabetes in Older Adults
    Susan J Zieman; Fiscal Year: 2012
    ....
  6. Longtitudinal Study of Dialysis
    Rulan S Parekh; Fiscal Year: 2012
    ..abstract_text> ..
  7. Musculoskeletal Disorder in Dialysis Patients
    Sharon M Moe; Fiscal Year: 2010
    ..These studies, Dr. Moe, and the strong clinical research support at Indiana Unviersity provide an excellent training environment for the development of future investigators in patient oriented research. ..
  8. BIOCHEMICAL AND GENETIC MARKERS OF TYPE 2 DIABETES RISK
    Frank B Hu; Fiscal Year: 2013
    ..Findings from this study can be used to motivate safer food and product manufacturing practices to contribute to the prevention of diabetes. ..
  9. Role of Fetuin-A in Tumor Cell Growth
    Josiah Ochieng; Fiscal Year: 2012
    ..The full understanding of this pathway has broad implications in the management and treatment strategies for majority of cancer types. ..
  10. Pregravid biomarkers of GDM risk, fetal growth and progression to diabetes
    MONIQUE MARIE HEDDERSON; Fiscal Year: 2013
    ..This research could have translational value in the prevention of GDM its progression to T2DM, and health sequelae in their offspring. ..
  11. Fetuin-A: A Novel Biomarker of Vascular Calcification and Diabetes Mellitus
    Joachim H Ix; Fiscal Year: 2010
    ..The results of this epidemiologic study will provide novel insights into their pathogenesis and may ultimately identify novel therapeutic targets for their prevention or treatment. ..
  12. Role of Calpains in Plasma Membrane Repair
    RONALD MELLGREN; Fiscal Year: 2009
    ..Recently, we demonstrated that the blood plasma protein fetuin A stabilizes m-calpain and facilitates plasmalemma repair...
  13. DNA methylation alterations in response to pesticides exposure
    Lifang Hou; Fiscal Year: 2010
    ..Our recent analysis of the Agricultural Health Study (AHS) cohort, the largest prospective study in the world of pesticide applicators from Iowa and North Carolina, also ..
  14. Gary E Fraser; Fiscal Year: 2015
    ..provided by applicant): Between 2002-2007 we assembled a large cohort (N= 96,000) named Adventist Health Study-2 (AHS-2)...
  15. A Patient-Centered Strategy to Reduce Diabetes Disparities in Chinese Americans
    Susan Ivey; Fiscal Year: 2009
    ..This proposed project is a community-academic collaboration between Asian Health Services (AHS), the Association of Asian Pacific Community Health Organizations, and the University of Calilfornia, Berkeley that ..
  16. OTHER FUNCTIONS TAS::75 0849::TAS AGRICULTURAL HEALTH STUDY PHASE IV--MOD 3:
    Marsha Dunn; Fiscal Year: 2012
    The Agricultural Health Study (AHS) cohort consists of approximately 52,000 private pesticide applicators (primarily farmers) and 32,000 spouses of private applicators from Iowa and North Carolina, as well as approximately 5,000 ..
  17. OTHER FUNCTIONS TAS::75 0849::TAS AGRICULTURAL HEALTH STUDY PHASE IV--MOD 3:
    Marsha Dunn; Fiscal Year: 2013
    The Agricultural Health Study (AHS) cohort consists of approximately 52,000 private pesticide applicators (primarily farmers) and 32,000 spouses of private applicators from Iowa and North Carolina, as well as approximately 5,000 ..
  18. Sun Exposure and Melanoma in Agricultural Workers
    Leslie Dennis; Fiscal Year: 2009
    ..A unique population, the Agricultural Health Study (AHS) cohort, will be used to examine sun exposure, sun protection behavior, and factors affecting these behaviors ..
  19. JOHN JOSEPH ROSSI; Fiscal Year: 2016
    ..of small molecule drugs in highly active anti-retroviral therapy (HAART) to stop or thwart HIV propagation ahs had a major impact on delaying the progression from HIV-1 infection to the development of AIDS...
  20. Neurological Outcomes Among Pesticide Applicators
    Fredric Gerr; Fiscal Year: 2009
    ..will be recruited from among pesticide applicators currently enrolled in the Agricultural Health Study (AHS), a federally funded cohort study of licensed pesticide applicators from Iowa and North Carolina...
  21. NIEHS SUPPORT OF THE AHS COHORT STUDY AT NCI
    Charles Knott; Fiscal Year: 2009
    ..administering a 30-minute CATI questionnaire and achieve at least a 75 percent participation rate;12) linking the AHS cohort to the State Cancer Registry and Vital Statistics Office mortality file and the National Death Index to ..
  22. Skin Pigmentation and Parkinson's Disease Risk
    Caroline Tanner; Fiscal Year: 2003
    ..melanin concentration) and risk of PD in a unique human population of farmers in the Agricultural Health Study (AHS)...
  23. Population-based Surveillance for Zoonotic Influenza A
    Gregory Gray; Fiscal Year: 2005
    ..We will use data from the 90,000-person Agricultural Health Study (AHS) to identify study subjects who are occupationally exposed to swine (n=200), poultry (n=200), swine and poultry (n=..
  24. Anjon Audhya; Fiscal Year: 2016
    ..The Molecular and Cellular Pharmacology Program has been strongly supported across campus. This initiative ahs revitalized the campus-wide Pharmacology curriculum, seminar series, and has sparked innumerable interdepartmental ..
  25. ALZHEIMER DISEASE AMONG SEVENTH-DAY ADVENTISTS
    Zoreh Davanipour; Fiscal Year: 1992
    ..announcements in Adventist publications and church-affiliated broadcast media; through the Adventist Health System (AHS); and through family interviews...
  26. IMMUNOTOXICITY OF POLYCYCLIC AROMATIC HYDROCARBONS
    Scott Burchiel; Fiscal Year: 2001
    ..We will also examine the effects of AHs on channel-mediated Ca2+ influx...
  27. TMS Intervention Development for Auditory Hallucinations
    Ralph Hoffman; Fiscal Year: 2003
    ..Forty patients reporting AHs will be enrolled in a randomized double-blind, parallel design...
  28. INTERGENERATIONAL INFLUENCE OF SUBSTANCE USE ON CHILDREN
    KARL HILL; Fiscal Year: 2004
    ..in 1985 when subjects entered the fifth grade in 18 elementary schools serving high crime neighborhoods, ahs been tracked and interviewed over an eleven-year period through 1996 when subjects were 21 years old...
  29. Decomposing Neighborhood Change
    Terra McKinnish; Fiscal Year: 2009
    ..different demographic groups? We use two confidential data sources: the non-public use American Housing Survey (AHS) national sample, covering 1985-2005, and the 1990 and 2000 Decennial Long Form samples...
  30. PESTICIDES AND RISK IN THE AGRICUTURAL HEALTH STUDY
    Caroline Tanner; Fiscal Year: 2004
    ..to pesticides and other factors by conducting a nested case-control study in the Agricultural Health Study (AHS), using a 3:1 case-control ratio and employing classical methods for multi-variate analysis...
  31. Urban Diabetics: Primary Care and Hospitalizations
    Jessica Robbins; Fiscal Year: 2004
    ..database maintained by the Philadelphia Department of Public Health Division of Ambulatory Health Services (AHS) and the hospital discharges database maintained by the Pennsylvania Health Care Cost Containment Council (PHC4)...
  32. RESISTANCE TO SEIZURE INDUCED DAMAGE
    Ellen Sperber; Fiscal Year: 1999
    ..form of epilepsy in human adults, associated with a unique pattern of damage referred to as Ammon's horn Sclersis (AHS). It has been suggested that this type of damage is the result of seizures early in life...
  33. Role of Complement Proteins in E. coli Meningitis
    PRASADARAO NEMANI; Fiscal Year: 2003
    ..The E. coli invasion of the BBB was significantly reduced in the presence of adult human serum (AHS) when compared to cord blood serum (CBS) using the investigator's in vitro model of the BBB, the cultured brain ..
  34. Biological and Psychosocial Manifestations of Religion
    Jerry Lee; Fiscal Year: 2009
    ..Whereas AHS-2 focuses on diet and its effect on cancer incidence, our research involving 10,000 of AHS-2 participants will ..
  35. Regulation of Vascular Calcification in Diabetes
    XUENING CHEN; Fiscal Year: 2007
    ....
  36. Neuroprotective Role of Fetuin in Cerebral Ischemia
    Haichao Wang; Fiscal Year: 2008
    ..Answers to these questions will improve our understanding of the pathophysiology of ischemic neural injury, and identify novel therapeutic agents for the treatment of stroke and related disorders. ..
  37. MATRIX GLA PROTEIN AND CARTILAGE CALCIFICATION
    Paul Price; Fiscal Year: 2001
    ..The investigators will further study the demonstrated ability of MGP to inhibit calcification in supersaturated solutions, and will investigate the ability of MGP to inhibit matrix vesicle -initiated calcification. ..
  38. Team COOL Pilot Study
    Martha Kubik; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  39. Initiation and Inhibition of Medial Artery Calcification
    Paul Price; Fiscal Year: 2008
    ..abstract_text> ..
  40. CRP, Diabetes, Atherothrombosis
    Ishwarlal Jialal; Fiscal Year: 2010
    ..CRP augments oxidative stress and inflammation in the diabetic milieu will eventually lead to therapies targeted at reducing inflammation and oxidative stress in diabetes and resulting in a decrease in vasculopathies ..
  41. PROGRAM PROJECT GRANT
    Jouni Uitto; Fiscal Year: 2006
    ..abstract_text> ..
  42. Immunological Secretomes of the Early Anthrax Infection
    Chun Ming Huang; Fiscal Year: 2010
    ..This protein will thus serve as a positive control to evaluate novel antigens identified in the proposed studies. ..
  43. Proteomics of mouse models for aging and longevity
    Makoto Kuro O; Fiscal Year: 2008
    ..These studies are expected to provide critical information that promotes a better understanding of the molecular mechanisms of aging and longevity. [unreadable] [unreadable]..
  44. CANCER EPIDEMIOLOGY IN ADVENTISTS--A LOW RISK GROUP
    Gary Fraser; Fiscal Year: 2008
    ..PERFORMANCE SITE ========================================Section End=========================================== ..
  45. Pediatric Training Program in Chronic Kidney Diseases
    Keith Hruska; Fiscal Year: 2008
    ....
  46. Anthrax vaccination by targeting spore germination
    Chun Ming Huang; Fiscal Year: 2005
    ..This unprecedented study will elicit the pathological mechanisms and vaccination capabilities of immune inhibitor A and camelysin expressed in Bacillus anthracis. ..
  47. Circulating Age-related Lipid Mediators in Thrombosis
    Thomas M McIntyre; Fiscal Year: 2010
    ....
  48. Pyrosequencer
    Isaac Wirgin; Fiscal Year: 2004
    ..abstract_text> ..
  49. Leukocyte Responses to Endotoxin
    Thomas McIntyre; Fiscal Year: 2005
    ..We anticipate this work will lead to a new class of anti-inflammatory agents. ..
  50. Trace elements among Iowa pesticide applicators
    Leslie Dennis; Fiscal Year: 2004
    The Agricultural Health Study (AHS) is an established, on-going prospective cohort study examining the relationship between agricultural exposures, such as pesticide use, and disease among applicators in Iowa and North Carolina...
  51. Ondansetron and Naltrexone:Cue Reactivity and Drinking
    Damaris Rohsenow; Fiscal Year: 2007
    ..Evidence will also be provided about subpopulations more likely to benefit from each medications. ..
  52. Tanning bed use among UI Students
    Leslie Dennis; Fiscal Year: 2003
    ..abstract_text> ..
  53. PROJECT TOWARDS NO DRUG ABUSE COMPONENTS ANALYSIS
    STEVEN SUSSMAN; Fiscal Year: 2003
    ..We will apply a series of sophisticated models to analyze the collected data for potential experimental, mediational and moderational effects as specified by hypotheses generated from the underlying theoretical base. ..
  54. MECHANISM FOR BONE SIALOPROTEIN TO NUCLEATE BIOAPATITE
    RONALD MIDURA; Fiscal Year: 2002
    ..abstract_text> ..
  55. Mechanisms of Resistance of Aquatic Vertebrate Populations to Mixtures
    Isaac Wirgin; Fiscal Year: 2008
    ..Novel proteins associated with AHRs or DREs will be identified using a proteomics[unreadable] approach and their expression compared between tomcod from the HR and susceptible populations. ..
  56. INCREASING ALCOHOLICS MOTIVATION TO QUIT SMOKING
    Damaris Rohsenow; Fiscal Year: 2001
    ..The effects of the intervention will be examined on number of smoking quit attempts, reductions in nicotine dose delivery, smoking treatment attended, alcohol and drug use, etc., during the next 12 months. ..
  57. WAVE DNA Fragment Analysis System
    Jouni Uitto; Fiscal Year: 2001
    ..It is highly suitable for analysis of a set of genes in a large number of individuals as well as identification of mutations and polymorphisms in many genes of interest. ..
  58. Molecular Genetics of Familial Tumoral Calcinosis
    Jouni Uitto; Fiscal Year: 2009
    ..abstract_text> ..
  59. MATRIX PROTEIN/INTEGRIN MEDIATED OSTEOCLAST REGULATION
    Keith Hruska; Fiscal Year: 2004
    ..Studies in this proposal will be performed in avian and murine osteoclasts that are transduced by fusion proteins containing a human immunodeficiency virus peptide, TAT, which can transduce proteins across cell membranes. ..
  60. Neural Network Models of Language
    Ralph Hoffman; Fiscal Year: 2005
    ..These findings will significantly advance our understanding of illness mechanisms in schizophrenia and direct future research aimed at developing more selective treatments that reverse these abnormalities. ..
  61. Rapid protein crystallization by surface mutagenesis
    Zygmunt Derewenda; Fiscal Year: 2004
    ..Funds are requested to further test the general applicability and success rate of this method, and to apply the method to a subset of targets selected for the Structural Genomic Initiative. ..
  62. 12th International Symposium on Basement Membranes
    Jouni Uitto; Fiscal Year: 2005
    ..In that sense, the meeting will meet some of the goals of the National Institutes of Health Roadmap Initiative. ..
  63. Preparing high resolution membrane protein crystals
    Zygmunt Derewenda; Fiscal Year: 2005
    ..abstract_text> ..
  64. BIOLOGICAL ACTIVITY OF OXIDIZED PHOSPHOLIPIDS
    Thomas McIntyre; Fiscal Year: 2008
    ..5) all these events are controlled by the oxidized phospholipid phospholipase PAF acetylhydrolase. ..
  65. Endotoxin Generated Lipid Second Messengers
    Thomas McIntyre; Fiscal Year: 2006
    ..One non-hydrolyzable LPA analog blocks PPARy function and might define a new class of anti-infiammatory, anti-lipidic agents. ..
  66. COLLAGEN BIOSYNTHESIS OF CULTURED FIBROBLASTS
    Jouni Uitto; Fiscal Year: 2006
    ....
  67. Secretomes captured in vivo via ultrafiltration probes
    Chun Ming Huang; Fiscal Year: 2008
    ..We believe that using CUF probes/Mass spectrometry will be a powerful tool which can be applied to other animal models and other human diseases. [unreadable] [unreadable] [unreadable]..
  68. Acne Vaccines Targeting a Surface Sialidase and a Secreted CAMP Factor Toxin
    Chun Ming Huang; Fiscal Year: 2008
    ..The goal of this proposal is to develop systemically effective acne vaccines that can specifically suppress P. acnes-induced skin inflammation without disturbing the balance of skin flora. [unreadable] [unreadable] [unreadable]..
  69. rTMS Clinical Trial for Auditory Hallucinations
    RALPH EDWARD HOFFMAN; Fiscal Year: 2010
    ..suggest that speech processing areas of the brain play an important role in producing auditory hallucinations (AHs)...
  70. Agents for in vivo control of adult stem cells
    Carl Gregory; Fiscal Year: 2007
    ..These molecules are clinically relevant for the treatment of diseases such as Osteogenesis Imperfecta (brittle bone disease) and malignant bone disease and critical size bone injuries. [unreadable] [unreadable] [unreadable]..