AHSG

Summary

Gene Symbol: AHSG
Description: alpha 2-HS glycoprotein
Alias: A2HS, AHS, APMR1, FETUA, HSGA, alpha-2-HS-glycoprotein, alpha-2-Z-globulin, ba-alpha-2-glycoprotein, fetuin-A
Species: human
Products:     AHSG

Top Publications

  1. Rittig K, Thamer C, Haupt A, Machann J, Peter A, Balletshofer B, et al. High plasma fetuin-A is associated with increased carotid intima-media thickness in a middle-aged population. Atherosclerosis. 2009;207:341-2 pubmed publisher
  2. Saroha A, Kumar S, Chatterjee B, Das H. Jacalin bound plasma O-glycoproteome and reduced sialylation of alpha 2-HS glycoprotein (A2HSG) in rheumatoid arthritis patients. PLoS ONE. 2012;7:e46374 pubmed publisher
    ..Altered glycoprotein expression and functional as well as structural studies of glycans might help in the diagnosis of RA and understanding the disease pathogenesis. ..
  3. Sakwe A, Koumangoye R, Goodwin S, Ochieng J. Fetuin-A ({alpha}2HS-glycoprotein) is a major serum adhesive protein that mediates growth signaling in breast tumor cells. J Biol Chem. 2010;285:41827-35 pubmed publisher
    ..Taken together, our data show the significance of fetuin-A in tumor cell growth mechanisms in vitro and open new research vistas for this protein. ..
  4. Eraso L, Ginwala N, Qasim A, Mehta N, Dlugash R, Kapoor S, et al. Association of lower plasma fetuin-a levels with peripheral arterial disease in type 2 diabetes. Diabetes Care. 2010;33:408-10 pubmed publisher
    ..Our findings suggest a potentially unique role for fetuin-A deficiency as a biomarker of PAD in patients with type 2 diabetes. ..
  5. Porazko T, Kuzniar J, Kusztal M, Kuzniar T, Weyde W, Kuriata Kordek M, et al. Increased aortic wall stiffness associated with low circulating fetuin A and high C-reactive protein in predialysis patients. Nephron Clin Pract. 2009;113:c81-7 pubmed publisher
    ..The aim of the study was to analyze relationships between inflammatory markers, fetuin A and arterial wall stiffness in CKD patients in the predialysis period and on maintenance dialysis...
  6. Kaess B, Enserro D, McManus D, Xanthakis V, Chen M, Sullivan L, et al. Cardiometabolic correlates and heritability of fetuin-A, retinol-binding protein 4, and fatty-acid binding protein 4 in the Framingham Heart Study. J Clin Endocrinol Metab. 2012;97:E1943-7 pubmed publisher
    ....
  7. Ix J, Shlipak M, Brandenburg V, Ali S, Ketteler M, Whooley M. Association between human fetuin-A and the metabolic syndrome: data from the Heart and Soul Study. Circulation. 2006;113:1760-7 pubmed
    ..01). Higher human fetuin-A concentrations are strongly associated with MetS and an atherogenic lipid profile. Future studies should evaluate whether fetuin-A predicts coronary artery disease risk. ..
  8. Dowling P, Clarke C, Hennessy K, Torralbo Lopez B, Ballot J, Crown J, et al. Analysis of acute-phase proteins, AHSG, C3, CLI, HP and SAA, reveals distinctive expression patterns associated with breast, colorectal and lung cancer. Int J Cancer. 2012;131:911-23 pubmed publisher
    ..We have previously demonstrated that levels of alpha-2-heremans-schmid-glycoprotein (AHSG), complement component C3 (C3), clusterin (CLI), haptoglobin (HP) and serum amyloid A (SAA) are significantly ..
  9. Axelsson J, Wang X, Ketteler M, Qureshi A, Heimburger O, Barany P, et al. Is fetuin-A/alpha2-Heremans-Schmid glycoprotein associated with the metabolic syndrome in patients with chronic kidney disease?. Am J Nephrol. 2008;28:669-76 pubmed publisher
    ..We hypothesized that the circulating calcification inhibitor fetuin-A/AHSG, which is also a natural inhibitor of the tyrosine kinase insulin receptor, could be one factor explaining the ..
  10. Dahlman I, Eriksson P, Kaaman M, Jiao H, Lindgren C, Kere J, et al. alpha2-Heremans-Schmid glycoprotein gene polymorphisms are associated with adipocyte insulin action. Diabetologia. 2004;47:1974-9 pubmed
    ..of single-nucleotide polymorphisms (SNPs) in the gene encoding the human alpha(2)-Heremans-Schmid glycoprotein (AHSG) on obesity and insulin action in adipocytes. We screened 24 individuals for SNPs in AHSG...

Detail Information

Publications62

  1. Rittig K, Thamer C, Haupt A, Machann J, Peter A, Balletshofer B, et al. High plasma fetuin-A is associated with increased carotid intima-media thickness in a middle-aged population. Atherosclerosis. 2009;207:341-2 pubmed publisher
  2. Saroha A, Kumar S, Chatterjee B, Das H. Jacalin bound plasma O-glycoproteome and reduced sialylation of alpha 2-HS glycoprotein (A2HSG) in rheumatoid arthritis patients. PLoS ONE. 2012;7:e46374 pubmed publisher
    ..Altered glycoprotein expression and functional as well as structural studies of glycans might help in the diagnosis of RA and understanding the disease pathogenesis. ..
  3. Sakwe A, Koumangoye R, Goodwin S, Ochieng J. Fetuin-A ({alpha}2HS-glycoprotein) is a major serum adhesive protein that mediates growth signaling in breast tumor cells. J Biol Chem. 2010;285:41827-35 pubmed publisher
    ..Taken together, our data show the significance of fetuin-A in tumor cell growth mechanisms in vitro and open new research vistas for this protein. ..
  4. Eraso L, Ginwala N, Qasim A, Mehta N, Dlugash R, Kapoor S, et al. Association of lower plasma fetuin-a levels with peripheral arterial disease in type 2 diabetes. Diabetes Care. 2010;33:408-10 pubmed publisher
    ..Our findings suggest a potentially unique role for fetuin-A deficiency as a biomarker of PAD in patients with type 2 diabetes. ..
  5. Porazko T, Kuzniar J, Kusztal M, Kuzniar T, Weyde W, Kuriata Kordek M, et al. Increased aortic wall stiffness associated with low circulating fetuin A and high C-reactive protein in predialysis patients. Nephron Clin Pract. 2009;113:c81-7 pubmed publisher
    ..The aim of the study was to analyze relationships between inflammatory markers, fetuin A and arterial wall stiffness in CKD patients in the predialysis period and on maintenance dialysis...
  6. Kaess B, Enserro D, McManus D, Xanthakis V, Chen M, Sullivan L, et al. Cardiometabolic correlates and heritability of fetuin-A, retinol-binding protein 4, and fatty-acid binding protein 4 in the Framingham Heart Study. J Clin Endocrinol Metab. 2012;97:E1943-7 pubmed publisher
    ....
  7. Ix J, Shlipak M, Brandenburg V, Ali S, Ketteler M, Whooley M. Association between human fetuin-A and the metabolic syndrome: data from the Heart and Soul Study. Circulation. 2006;113:1760-7 pubmed
    ..01). Higher human fetuin-A concentrations are strongly associated with MetS and an atherogenic lipid profile. Future studies should evaluate whether fetuin-A predicts coronary artery disease risk. ..
  8. Dowling P, Clarke C, Hennessy K, Torralbo Lopez B, Ballot J, Crown J, et al. Analysis of acute-phase proteins, AHSG, C3, CLI, HP and SAA, reveals distinctive expression patterns associated with breast, colorectal and lung cancer. Int J Cancer. 2012;131:911-23 pubmed publisher
    ..We have previously demonstrated that levels of alpha-2-heremans-schmid-glycoprotein (AHSG), complement component C3 (C3), clusterin (CLI), haptoglobin (HP) and serum amyloid A (SAA) are significantly ..
  9. Axelsson J, Wang X, Ketteler M, Qureshi A, Heimburger O, Barany P, et al. Is fetuin-A/alpha2-Heremans-Schmid glycoprotein associated with the metabolic syndrome in patients with chronic kidney disease?. Am J Nephrol. 2008;28:669-76 pubmed publisher
    ..We hypothesized that the circulating calcification inhibitor fetuin-A/AHSG, which is also a natural inhibitor of the tyrosine kinase insulin receptor, could be one factor explaining the ..
  10. Dahlman I, Eriksson P, Kaaman M, Jiao H, Lindgren C, Kere J, et al. alpha2-Heremans-Schmid glycoprotein gene polymorphisms are associated with adipocyte insulin action. Diabetologia. 2004;47:1974-9 pubmed
    ..of single-nucleotide polymorphisms (SNPs) in the gene encoding the human alpha(2)-Heremans-Schmid glycoprotein (AHSG) on obesity and insulin action in adipocytes. We screened 24 individuals for SNPs in AHSG...
  11. Oikawa O, Higuchi T, Yamazaki T, Yamamoto C, Fukuda N, Matsumoto K. Evaluation of serum fetuin-A relationships with biochemical parameters in patients on hemodialysis. Clin Exp Nephrol. 2007;11:304-308 pubmed publisher
    ..05). These data suggest that a low fetuin-A level is a useful predictor of malnutrition and inflammation, as well as being a useful predictor of the cardiac failure caused by an increased ventricular load in hemodialysis patients. ..
  12. Reinehr T, Roth C. Fetuin-A and its relation to metabolic syndrome and fatty liver disease in obese children before and after weight loss. J Clin Endocrinol Metab. 2008;93:4479-85 pubmed publisher
    ..Therefore, fetuin-A might be a new promising link between obesity and its comorbidities. ..
  13. Fisher E, Stefan N, Saar K, Drogan D, Schulze M, Fritsche A, et al. Association of AHSG gene polymorphisms with fetuin-A plasma levels and cardiovascular diseases in the EPIC-Potsdam study. Circ Cardiovasc Genet. 2009;2:607-13 pubmed publisher
    ..capturing the common genetic variation of the fetuin-A coding gene alpha(2)-Heremans-Schmid glycoprotein (AHSG) were genotyped in a case-cohort comprising 214 MI cases, 154 ischemic stroke cases, and 2152 persons who remained ..
  14. Ix J, Biggs M, Mukamal K, Kizer J, Zieman S, Siscovick D, et al. Association of fetuin-a with incident diabetes mellitus in community-living older adults: the cardiovascular health study. Circulation. 2012;125:2316-22 pubmed publisher
    ..01). Higher fetuin-A is associated with incident diabetes mellitus in older persons regardless of sex, race, or prevalent CVD status. The association may be attenuated in those ≥ 75 years of age. ..
  15. Ou H, Wu H, Hung H, Yang Y, Wu J, Chang C. Endoplasmic reticulum stress induces the expression of fetuin-A to develop insulin resistance. Endocrinology. 2012;153:2974-84 pubmed publisher
    ..Moreover, ER stress induced by high glucose and palmitate increased the expression of fetuin-A and further contributed to the development of insulin resistance. ..
  16. Caglar K, Yilmaz M, Saglam M, Cakir E, Kilic S, Sonmez A, et al. Serum fetuin-a concentration and endothelial dysfunction in chronic kidney disease. Nephron Clin Pract. 2008;108:c233-40 pubmed publisher
    ..216, p < 0.001). These data in a selected cohort of CKD patients indicate that fetuin-A may be one of the contributing factors for the development of endothelial dysfunction in CKD patients. ..
  17. Andersen G, Burgdorf K, Sparsø T, Borch Johnsen K, Jørgensen T, Hansen T, et al. AHSG tag single nucleotide polymorphisms associate with type 2 diabetes and dyslipidemia: studies of metabolic traits in 7,683 white Danish subjects. Diabetes. 2008;57:1427-32 pubmed publisher
    The gene encoding the alpha2 Heremans-Schmid glycoprotein (AHSG) is a credible biological and positional candidate gene for type 2 diabetes and the metabolic syndrome, and previous attempts to relate AHSG variation with type 2 diabetes ..
  18. Jersmann H, Dransfield I, Hart S. Fetuin/alpha2-HS glycoprotein enhances phagocytosis of apoptotic cells and macropinocytosis by human macrophages. Clin Sci (Lond). 2003;105:273-8 pubmed
    ..Fetuin also substantially increased the uptake of labelled dextran 70000 by macrophages, which occurs by macropinocytosis, suggesting that this may be one of the mechanisms utilized for apoptotic cell uptake. ..
  19. Roos M, Richart T, Kouznetsova T, von Eynatten M, Lutz J, Heemann U, et al. Fetuin-A and arterial stiffness in patients with normal kidney function. Regul Pept. 2009;154:39-43 pubmed publisher
    To evaluate the association between fetuin-A level (AHSG), its encoding gene (Thr256Ser) and arterial function in subjects with normal kidney function. The aortic pulse wave velocity (aPWV) is a predictor for cardiovascular mortality...
  20. Jahnen Dechent W, Heiss A, Schafer C, Ketteler M. Fetuin-A regulation of calcified matrix metabolism. Circ Res. 2011;108:1494-509 pubmed publisher
    ..Fetuin-A deficiency is associated with soft tissue calcification in mice and humans. ..
  21. Yilmaz Y, Yonal O, Kurt R, Ari F, Oral A, Celikel C, et al. Serum fetuin A/α2HS-glycoprotein levels in patients with non-alcoholic fatty liver disease: relation with liver fibrosis. Ann Clin Biochem. 2010;47:549-53 pubmed publisher
    Serum concentrations of fetuin A/α2HS-glycoprotein (AHSG) have been linked to human metabolic alterations and can serve as an indicator of liver cell function...
  22. Inoue M, Takata H, Ikeda Y, Suehiro T, Inada S, Osaki F, et al. A promoter polymorphism of the alpha2-HS glycoprotein gene is associated with its transcriptional activity. Diabetes Res Clin Pract. 2008;79:164-70 pubmed
    alpha2-Heremans Schmid glycoprotein (AHSG), also designated fetuin-A, is an abundant plasma protein that is expressed in hepatocytes...
  23. Karamessinis P, Malamitsi Puchner A, Boutsikou T, Makridakis M, Vougas K, Fountoulakis M, et al. Marked defects in the expression and glycosylation of alpha2-HS glycoprotein/fetuin-A in plasma from neonates with intrauterine growth restriction: proteomics screening and potential clinical implications. Mol Cell Proteomics. 2008;7:591-9 pubmed
    ..b>Fetuin A is a glycoprotein that has been associated with promotion of in vitro cell replication, fetal growth and ..
  24. Emoto M, Mori K, Lee E, Kawano N, Yamazaki Y, Tsuchikura S, et al. Fetuin-A and atherosclerotic calcified plaque in patients with type 2 diabetes mellitus. Metabolism. 2010;59:873-8 pubmed publisher
    ..753; 95% confidence interval, 0.608-0.933; P = .010). These results suggest that fetuin-A may inhibit the calcification of atherosclerotic plaques independently of the dialyzed condition. ..
  25. Caglar K, Yilmaz M, Saglam M, Cakir E, Kilic S, Eyileten T, et al. Endothelial dysfunction and fetuin A levels before and after kidney transplantation. Transplantation. 2007;83:392-7 pubmed
    ..The aim of this study was to investigate the relation between fetuin A levels and ED in kidney transplant recipients...
  26. Haukeland J, Dahl T, Yndestad A, Gladhaug I, Løberg E, Haaland T, et al. Fetuin A in nonalcoholic fatty liver disease: in vivo and in vitro studies. Eur J Endocrinol. 2012;166:503-10 pubmed publisher
    b>Fetuin A has been associated with insulin resistance and the metabolic syndrome. We therefore explored the role of fetuin A in nonalcoholic fatty liver disease (NAFLD). Cross-sectional and intervention studies...
  27. Hennige A, Staiger H, Wicke C, Machicao F, Fritsche A, Haring H, et al. Fetuin-A induces cytokine expression and suppresses adiponectin production. PLoS ONE. 2008;3:e1765 pubmed publisher
    The secreted liver protein fetuin-A (AHSG) is up-regulated in hepatic steatosis and the metabolic syndrome. These states are strongly associated with low-grade inflammation and hypoadiponectinemia...
  28. Stefan N, Fritsche A, Weikert C, Boeing H, Joost H, Haring H, et al. Plasma fetuin-A levels and the risk of type 2 diabetes. Diabetes. 2008;57:2762-7 pubmed publisher
    ..05 [1.02-1.07]). Furthermore, fetuin-A was associated with increased diabetes risk particularly in individuals with elevated plasma glucose. Our data suggest that fetuin-A is an independent risk factor of type 2 diabetes. ..
  29. Jenkins N, McKenzie J, Hagberg J, Witkowski S. Plasma fetuin-A concentrations in young and older high- and low-active men. Metabolism. 2011;60:265-71 pubmed publisher
    ..Therefore, the maintenance of low levels of circulating fetuin-A may be a novel mechanism contributing to enhanced insulin sensitivity with regular physical activity. ..
  30. Ketteler M, Bongartz P, Westenfeld R, Wildberger J, Mahnken A, Böhm R, et al. Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: a cross-sectional study. Lancet. 2003;361:827-33 pubmed
    ..Fetuin-A (alpha2-Heremans Schmid glycoprotein; AHSG) is an important circulating inhibitor of calcification in vivo, and is downregulated during the acute-phase ..
  31. Haglund A, Ek B, Ek P. Phosphorylation of human plasma alpha2-Heremans-Schmid glycoprotein (human fetuin) in vivo. Biochem J. 2001;357:437-45 pubmed
    ....
  32. El Shehaby A, Zakaria A, El Khatib M, Mostafa N. Association of fetuin-A and cardiac calcification and inflammation levels in hemodialysis patients. Scand J Clin Lab Invest. 2010;70:575-82 pubmed publisher
    ..Assessment of both cardiac calcification and serum levels of fetuin-A may be of value to identify those subjects at higher risk of development and progression of vascular lesion and may be a novel therapeutic approach. ..
  33. Osawa M, Tian W, Horiuchi H, Kaneko M, Umetsu K. Association of alpha2-HS glycoprotein (AHSG, fetuin-A) polymorphism with AHSG and phosphate serum levels. Hum Genet. 2005;116:146-51 pubmed
    Alpha2-HS glycoprotein (AHSG), also known as fetuin-A, is a plasma protein displaying high-affinity interaction with calcium phosphate, by which ectopic vascular calcification is prevented...
  34. Lee C, Bowman B, Yang F. Human alpha 2-HS-glycoprotein: the A and B chains with a connecting sequence are encoded by a single mRNA transcript. Proc Natl Acad Sci U S A. 1987;84:4403-7 pubmed
    The alpha 2-HS-glycoprotein (AHSG) is a plasma protein reported to play roles in bone mineralization and in the immune response. It is composed of two subunits, the A and B chains...
  35. Fiore C, Celotta G, Politi G, Di Pino L, Castelli Z, Mangiafico R, et al. Association of high alpha2-Heremans-Schmid glycoprotein/fetuin concentration in serum and intima-media thickness in patients with atherosclerotic vascular disease and low bone mass. Atherosclerosis. 2007;195:110-5 pubmed
    Alpha2-Heremans-Schmid glycoprotein (AHSG; fetuin), a member of the cystatin superfamily of cysteine protease inhibitors involved in vascular pathology and bone metabolism, has been reported to be reduced in patients with atherosclerosis ..
  36. Heiss A, DuChesne A, Denecke B, Grötzinger J, Yamamoto K, Renne T, et al. Structural basis of calcification inhibition by alpha 2-HS glycoprotein/fetuin-A. Formation of colloidal calciprotein particles. J Biol Chem. 2003;278:13333-41 pubmed
    Genetic evidence from mutant mice suggests that alpha(2)-HS glycoprotein/fetuin-A (Ahsg) is a systemic inhibitor of precipitation of basic calcium phosphate preventing unwanted calcification...
  37. Ix J, Wassel C, Kanaya A, Vittinghoff E, Johnson K, Koster A, et al. Fetuin-A and incident diabetes mellitus in older persons. JAMA. 2008;300:182-8 pubmed publisher
    ..72; 95% confidence interval, 0.98-3.05; P = .06). Among well-functioning older persons, serum fetuin-A is associated with incident diabetes, independent of other markers of insulin resistance. ..
  38. Nangami G, Watson K, Parker Johnson K, Okereke K, Sakwe A, Thompson P, et al. Fetuin-A (α2HS-glycoprotein) is a serum chemo-attractant that also promotes invasion of tumor cells through Matrigel. Biochem Biophys Res Commun. 2013;438:660-5 pubmed publisher
    ..The presence of plasminogen (PL) blunted the fetuin-A mediated chemotaxis. Taken together, the data suggest an in vivo chemotaxis/invasion role for fetuin-A. ..
  39. Ix J, Sharma K. Mechanisms linking obesity, chronic kidney disease, and fatty liver disease: the roles of fetuin-A, adiponectin, and AMPK. J Am Soc Nephrol. 2010;21:406-12 pubmed publisher
    ..Regulation of these early upstream pathways may provide new therapeutic targets for these increasingly common sequelae of obesity. ..
  40. Srinivas P, Wagner A, Reddy L, Deutsch D, Leon M, Goustin A, et al. Serum alpha 2-HS-glycoprotein is an inhibitor of the human insulin receptor at the tyrosine kinase level. Mol Endocrinol. 1993;7:1445-55 pubmed
    ..DNA sequence analysis reveals identity with the mRNA product of a human gene AHSG encoding a serum protein, alpha 2-Heremans Scmid-glycoprotein (alpha 2HSG), with heretofore unknown physiological ..
  41. Stenvinkel P, Wang K, Qureshi A, Axelsson J, Pecoits Filho R, Gao P, et al. Low fetuin-A levels are associated with cardiovascular death: Impact of variations in the gene encoding fetuin. Kidney Int. 2005;67:2383-92 pubmed
    ..evaluated the association between fetuin-A, clinical phenotype, and outcome, as well as the impact of fetuin gene (AHSG) polymorphisms on the protein product and outcome...
  42. Weikert C, Stefan N, Schulze M, Pischon T, Berger K, Joost H, et al. Plasma fetuin-a levels and the risk of myocardial infarction and ischemic stroke. Circulation. 2008;118:2555-62 pubmed publisher
    ..0001). Our data provide evidence for a link between high plasma fetuin-A levels and an increased risk of MI and IS. Therefore, more research is warranted to determine the role of fetuin-A in the pathophysiology of cardiovascular disease. ..
  43. Ketteler M. Fetuin-A and extraosseous calcification in uremia. Curr Opin Nephrol Hypertens. 2005;14:337-42 pubmed
    ..Deficiencies of calcification inhibitors such as fetuin-A are relevant pathomechanisms in the progression of uncontrolled vascular calcification and may offer potential for future therapeutic approaches. ..
  44. Cozzolino M, Galassi A, Biondi M, Turri O, Papagni S, Mongelli N, et al. Serum fetuin-A levels link inflammation and cardiovascular calcification in hemodialysis patients. Am J Nephrol. 2006;26:423-9 pubmed
    ..Chronic inflammation in HD patients leads to lower serum fetuin-A levels. The present study confirms the independent and significant association between reduced serum fetuin-A levels and multi-site CVC in HD. ..
  45. Kaden J, Reinöhl J, Blesch B, Brueckmann M, Haghi D, Borggrefe M, et al. Systemic and local levels of fetuin-A in calcific aortic valve stenosis. Int J Mol Med. 2007;20:193-7 pubmed
    ....
  46. Osawa M, Umetsu K, Ohki T, Nagasawa T, Suzuki T, Takeichi S. Molecular evidence for human alpha 2-HS glycoprotein (AHSG) polymorphism. Hum Genet. 1997;99:18-21 pubmed
    Alpha 2-HS glycoprotein (AHSG) is a human plasma glycoprotein that exhibits genetic polymorphism on isoelectric focusing (IEF). To identify the origin of two common alleles, AHSG*1 and *2, we examined nucleotide exchanges in the gene...
  47. Siddiq A, Lepretre F, Hercberg S, Froguel P, Gibson F. A synonymous coding polymorphism in the alpha2-Heremans-schmid glycoprotein gene is associated with type 2 diabetes in French Caucasians. Diabetes. 2005;54:2477-81 pubmed
    alpha2-Heremans-Schmid glycoprotein (AHSG) is an abundant plasma protein synthesized predominantly in the liver. The AHSG gene, consisting of seven exons and spanning 8...
  48. Molvarec A, Kalabay L, Derzsy Z, Szarka A, Halmos A, Stenczer B, et al. Preeclampsia is associated with decreased serum alpha(2)-HS glycoprotein (fetuin-A) concentration. Hypertens Res. 2009;32:665-9 pubmed publisher
    The purpose of this study was to determine serum alpha(2)-HS glycoprotein (AHSG) concentration and its diagnostic accuracy in preeclampsia...
  49. Naito C, Hashimoto M, Watanabe K, Shirai R, Takahashi Y, Kojima M, et al. Facilitatory effects of fetuin-A on atherosclerosis. Atherosclerosis. 2016;246:344-51 pubmed publisher
    ..Since the role of fetuin-A in atherosclerosis remains still controversial, we aimed to clarify it in this study...
  50. Suchanek P, Králova Lesná I, Poledne R, Lanska V, Hubacek J. An AHSG gene variant modulates basal metabolic rate and body composition development after a short-time lifestyle intervention. Neuro Endocrinol Lett. 2011;32 Suppl 2:32-6 pubmed
    The AHSG (alpha2 Heremans-Schmid glycoprotein) gene is suggested to be important for the regulation of body fat and insulin sensitivity...
  51. Kim J, Kim H, Ku S, Kim S, Choi Y, Moon S. Association between human alpha 2-Heremans Schmidt glycoprotein (AHSG) polymorphism and endometriosis in Korean women. Fertil Steril. 2004;82:1497-500 pubmed
    To evaluate the relationship between the alpha 2-Heremans Schmidt glycoprotein (AHSG) gene polymorphism and endometriosis. Case-control study. Department of Obstetrics and Gynecology, Seoul National University Hospital, Korea...
  52. Tian W, Li J, Hu S, Peng X, Li G, Liu X, et al. Proteomic identification of alpha-2-HS-glycoprotein as a plasma biomarker of hypopharyngeal squamous cell carcinoma. Int J Clin Exp Pathol. 2015;8:9021-31 pubmed
    ..The up-regulation proteins were alpha-2-HS-glycoprotein (AHSG), complement C4-B, haptoglobin, C-reactive protein, and ceruloplasmin, whereas the down-regulation proteins were ..
  53. Olivier E, Soury E, Ruminy P, Husson A, Parmentier F, Daveau M, et al. Fetuin-B, a second member of the fetuin family in mammals. Biochem J. 2000;350 Pt 2:589-97 pubmed
    ..However, like its fetuin-A counterpart, the fetuin-B mRNA level is down-regulated during the acute phase of experimentally induced inflammation in rat. ..
  54. Ziółkowska H, Wojnar J, Pańczyk Tomaszewska M, Roszkowska Blaim M. [Fetuin A in children with renal diseases]. Przegl Lek. 2006;63 Suppl 3:54-6 pubmed
    b>Fetuin A, 59 kDa protein, produced in the liver is a circulating inhibitor of vascular calcification. The aim of the study was to estimate a concentration of fetuin A in children with renal diseases...
  55. Mukhuty A, Fouzder C, Mukherjee S, Malick C, Mukhopadhyay S, Bhattacharya S, et al. Palmitate induced Fetuin-A secretion from pancreatic β-cells adversely affects its function and elicits inflammation. Biochem Biophys Res Commun. 2017;491:1118-1124 pubmed publisher
    ..FetA thus creates an inflammatory environment in the pancreatic islets that can become a possible cause behind pancreatic β-cell dysfunction in chronic hyperlipidemic condition. ..
  56. Chen C, Ye X, Wang Y, Chen Y, Tseng W. Differential Effects of Different Warm-up Protocols on Repeated Sprints-Induced Muscle Damage. J Strength Cond Res. 2017;: pubmed publisher
    ..of running (control); control with single leg slide curl (SLC); and control with active hamstring stretching (AHS)...
  57. Fourati R, Tedetti M, Guigue C, Goutx M, Zaghden H, Sayadi S, et al. Natural and anthropogenic particulate-bound aliphatic and polycyclic aromatic hydrocarbons in surface waters of the Gulf of Gabès (Tunisia, southern Mediterranean Sea). Environ Sci Pollut Res Int. 2017;: pubmed publisher
    Particulate-bound aliphatic and polycyclic aromatic hydrocarbons (AHs and PAHs) were investigated in the surface waters of the Gulf of Gabès (Tunisia, southern Mediterranean Sea)...
  58. Sugars R, Waddington R, Embery G. The interaction of recombinant decorin with alpha2HS-glycoprotein-implications for structural and functional investigations. Protein Expr Purif. 2002;25:180-8 pubmed
    ....
  59. Kuzniar J, Porazko T, Klinger M. Relationship between fetuin-A concentration, elevated levels of inflammatory markers, and arterial wall stiffness in end-stage kidney disease. J Ren Nutr. 2008;18:83-6 pubmed
    ..The arterial-stiffening process was unaffected by the Ca x P product, but occurred independent of elevated interleukin-6 levels. ..
  60. Briana D, Boutsikou M, Gourgiotis D, Boutsikou T, Baka S, Marmarinos A, et al. Serum fetuin-A/alpha2-HS-glycoprotein in human pregnancies with normal and restricted fetal growth. J Matern Fetal Neonatal Med. 2008;21:826-30 pubmed publisher
    ..Maternal and fetal fetuin-A concentrations are similar and positively correlated, indicating the likelihood of passive transplacental transfer of this substance. ..
  61. Uitto J, Li Q, Jiang Q. Pseudoxanthoma elasticum: molecular genetics and putative pathomechanisms. J Invest Dermatol. 2010;130:661-70 pubmed publisher
    ..Understanding of the pathomechanistic details of PXE provides a basis for the development of targeted molecular therapies for this currently intractable disease...
  62. Mori K, Ikari Y, Jono S, Emoto M, Shioi A, Koyama H, et al. Fetuin-A is associated with calcified coronary artery disease. Coron Artery Dis. 2010;21:281-5 pubmed publisher
    ..54; 95% confidence interval: 0.31-0.92; P = 0.025). Serum fetuin-A levels inversely correlated with advanced calcified coronary artery disease. ..