AGER

Summary

Gene Symbol: AGER
Description: advanced glycosylation end-product specific receptor
Alias: RAGE, SCARJ1, advanced glycosylation end product-specific receptor, RAGE isoform NtRAGE-delta, RAGE isoform sRAGE-delta, receptor for advanced glycation end-products variant 20
Species: human
Products:     AGER

Top Publications

  1. Repapi E, Sayers I, Wain L, Burton P, Johnson T, Obeidat M, et al. Genome-wide association study identifies five loci associated with lung function. Nat Genet. 2010;42:36-44 pubmed publisher
    ..11 x 10(-12)), 4q24 in GSTCD (2.18 x 10(-23)), 5q33 in HTR4 (P = 4.29 x 10(-9)), 6p21 in AGER (P = 3.07 x 10(-15)) and 15q23 in THSD4 (P = 7.24 x 10(-15))...
  2. Hancock D, Eijgelsheim M, Wilk J, Gharib S, Loehr L, Marciante K, et al. Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. Nat Genet. 2010;42:45-52 pubmed publisher
    ..We identified eight loci associated with FEV(1)/FVC (HHIP, GPR126, ADAM19, AGER-PPT2, FAM13A, PTCH1, PID1 and HTR4) and one locus associated with FEV(1) (INTS12-GSTCD-NPNT) at or near genome-wide ..
  3. Sukkar M, Wood L, Tooze M, Simpson J, McDonald V, Gibson P, et al. Soluble RAGE is deficient in neutrophilic asthma and COPD. Eur Respir J. 2012;39:721-9 pubmed publisher
    The receptor for advanced glycation end-products (RAGE) is a pattern-recognition receptor involved in the host response to injury, infection and inflammation. It is a membrane receptor, but also has soluble forms (sRAGE)...
  4. Yaser A, Huang Y, Zhou R, Hu G, Xiao M, Huang Z, et al. The Role of receptor for Advanced Glycation End Products (RAGE) in the proliferation of hepatocellular carcinoma. Int J Mol Sci. 2012;13:5982-97 pubmed publisher
    The receptor for advanced glycation end products (RAGE) is oncogenic and overexpressed in human cancers, but its role in hepatocellular carcinoma remains unclear...
  5. Sakaguchi M, Murata H, Yamamoto K, Ono T, Sakaguchi Y, Motoyama A, et al. TIRAP, an adaptor protein for TLR2/4, transduces a signal from RAGE phosphorylated upon ligand binding. PLoS ONE. 2011;6:e23132 pubmed publisher
    The receptor for advanced glycation end products (RAGE) is thought to be involved in the pathogenesis of a broad range of inflammatory, degenerative and hyperproliferative diseases...
  6. Srikrishna G, Nayak J, Weigle B, Temme A, Foell D, Hazelwood L, et al. Carboxylated N-glycans on RAGE promote S100A12 binding and signaling. J Cell Biochem. 2010;110:645-59 pubmed publisher
    The receptor for advanced glycation end products (RAGE) is a signaling receptor protein of the immunoglobulin superfamily implicated in multiple pathologies...
  7. Choi K, Han K, Ahn H, Hwang S, Hong H, Choi H, et al. Effects of exercise on sRAGE levels and cardiometabolic risk factors in patients with type 2 diabetes: a randomized controlled trial. J Clin Endocrinol Metab. 2012;97:3751-8 pubmed publisher
    ..27; P=0.019). Aerobic exercise increases sRAGE levels along with improvement of various cardiometabolic risk factors in patients with T2DM. ..
  8. Li K, Zhao B, Dai D, Yao S, Liang W, Yao L, et al. A functional p.82G>S polymorphism in the RAGE gene is associated with multiple sclerosis in the Chinese population. Mult Scler. 2011;17:914-21 pubmed publisher
    The receptor for advanced glycation end products (RAGE) and its proinflammatory ligand, S100-calgranulins, are critically implicated in the pathological progression of multiple sclerosis (MS)...
  9. Lu W, Feng B, Xie G, Liu F. Association of AGER gene G82S polymorphism with the severity of coronary artery disease in Chinese Han population. Clin Endocrinol (Oxf). 2011;75:470-4 pubmed publisher
    Advanced glycosylation end-product receptor (AGER) plays an important role in the development and progression of atherosclerosis...

More Information

Publications91

  1. Cheng D, Kim D, Cockayne D, Belousov A, Bitter H, Cho M, et al. Systemic soluble receptor for advanced glycation endproducts is a biomarker of emphysema and associated with AGER genetic variants in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2013;188:948-57 pubmed publisher
    ..Emphysema in chronic obstructive pulmonary disease (COPD) can be characterized by high-resolution chest computed tomography (HRCT); however, the repeated use of HRCT is limited because of concerns regarding radiation exposure and cost...
  2. Narvaez Rivera R, Rendon A, Salinas Carmona M, Rosas Taraco A. Soluble RAGE as a severity marker in community acquired pneumonia associated sepsis. BMC Infect Dis. 2012;12:15 pubmed publisher
    ..HMGB-1, sRAGE and RAGE have been involved in sepsis and their potential as severity markers has been proposed...
  3. Forbes J, Söderlund J, Yap F, Knip M, Andrikopoulos S, Ilonen J, et al. Receptor for advanced glycation end-products (RAGE) provides a link between genetic susceptibility and environmental factors in type 1 diabetes. Diabetologia. 2011;54:1032-42 pubmed publisher
    ..of studies examines human genetic susceptibility conferred by the receptor for advanced glycation end-products (RAGE) in type 1 diabetes and investigates how this may interact with a western environment...
  4. Zong H, Madden A, Ward M, Mooney M, Elliott C, Stitt A. Homodimerization is essential for the receptor for advanced glycation end products (RAGE)-mediated signal transduction. J Biol Chem. 2010;285:23137-46 pubmed publisher
    The receptor for advanced glycation end products (RAGE) is a pattern-recognition receptor that binds to diverse ligands and initiates a downstream proinflammatory signaling cascade...
  5. Bastek J, Brown A, Foreman M, McShea M, Anglim L, Adamczak J, et al. The soluble receptor for advanced glycation end products can prospectively identify patients at greatest risk for preterm birth. J Matern Fetal Neonatal Med. 2012;25:1762-8 pubmed publisher
    ..objective was to determine whether there was an association between levels of antenatal maternal serum soluble RAGE (sRAGE), drawn at the time of presentation with preterm labor (PTL), and subsequent preterm birth (PTB)...
  6. Li Y, Yang C, Ma G, Gu X, Chen M, Chen Y, et al. Association of polymorphisms of the receptor for advanced glycation end products gene with COPD in the Chinese population. DNA Cell Biol. 2014;33:251-8 pubmed publisher
    The receptor for advanced glycation end products (RAGE) is a cell surface molecule of the immunoglobulin superfamily that binds diverse endogenous ligands involved in the development of chronic diseases and inflammatory damage...
  7. Miniati M, Monti S, Basta G, Cocci F, Fornai E, Bottai M. Soluble receptor for advanced glycation end products in COPD: relationship with emphysema and chronic cor pulmonale: a case-control study. Respir Res. 2011;12:37 pubmed publisher
    The receptor for advanced glycation end products (RAGE) is a multiligand signal transduction receptor that can initiate and perpetuate inflammation...
  8. Basta G, Del Turco S, Navarra T, Mazzarisi A, Cocci F, Coceani M, et al. Inverse association between circulating levels of soluble receptor for advanced glycation end-products and coronary plaque burden. J Atheroscler Thromb. 2012;19:941-8 pubmed
    ..358, p=0.011). Circulating sRAGE levels are associated in an inverse manner with non-calcified plaque burden, suggesting that it may be related with early atherosclerosis and plaque progression. ..
  9. Smith D, Yerkovich S, Towers M, Carroll M, Thomas R, Upham J. Reduced soluble receptor for advanced glycation end-products in COPD. Eur Respir J. 2011;37:516-22 pubmed publisher
    ..AECOPD were associated with even lower sRAGE levels that increased with convalescence. Circulating sRAGE is lower in COPD and shows a strong correlation to the degree of airflow limitation. ..
  10. Park H, Adsit F, Boyington J. The 1.5 Å crystal structure of human receptor for advanced glycation endproducts (RAGE) ectodomains reveals unique features determining ligand binding. J Biol Chem. 2010;285:40762-70 pubmed publisher
    Interaction of the pattern recognition receptor, RAGE with key ligands such as advanced glycation end products (AGE), S100 proteins, amyloid ?, and HMGB1 has been linked to diabetic complications, inflammatory and neurodegenerative ..
  11. Martens H, Nienhuis H, Gross S, van der Steege G, Brouwer E, Berden J, et al. Receptor for advanced glycation end products (RAGE) polymorphisms are associated with systemic lupus erythematosus and disease severity in lupus nephritis. Lupus. 2012;21:959-68 pubmed publisher
    Interaction of advanced glycation end products (AGEs) with their receptors (RAGE) plays an important role in inflammation in auto-immune diseases. Several functional polymorphisms of RAGE have been described...
  12. Abdel Azeez H, El Okely A. Association of the receptor for advanced glycation end products (RAGE) -374 T/A gene polymorphism and circulating soluble RAGE with nephropathy in type 1 diabetic patients. Egypt J Immunol. 2009;16:95-106 pubmed
    The binding of advanced glycation end-products (AGEs) to their receptor (RAGE) may play an important role in the development of diabetic vascular complications. Circulating soluble RAGE (sRAGE) reflects tissue RAGE expression...
  13. McNair E, Wells C, Mabood Qureshi A, Basran R, Pearce C, Orvold J, et al. Soluble receptors for advanced glycation end products (sRAGE) as a predictor of restenosis following percutaneous coronary intervention. Clin Cardiol. 2010;33:678-85 pubmed publisher
    Interaction of advanced glycation end products (AGEs) with their receptor (RAGE) increases expression of inflammatory mediators (tumor necrosis factor alpha [TNF-?] and soluble vascular cell adhesion molecule-1 [sVCAM-1]) and induces ..
  14. Wang J, Zou L, Song Z, Lang X, Huang S, Lu F, et al. Meta-analysis of RAGE gene polymorphism and coronary heart disease risk. PLoS ONE. 2012;7:e50790 pubmed publisher
    ..and animal studies have shown an upregulated expression of advanced glycosylation end product-specific receptor (RAGE) in human atherosclerotic plaques 1 and in retina, messangial, and aortic vessels, suggesting an important role of ..
  15. Yamamoto K, Murata H, Putranto E, Kataoka K, Motoyama A, Hibino T, et al. DOCK7 is a critical regulator of the RAGE-Cdc42 signaling axis that induces formation of dendritic pseudopodia in human cancer cells. Oncol Rep. 2013;29:1073-9 pubmed publisher
    ..Growing evidence indicates that the receptor for advanced glycation end products (RAGE) plays a pivotal role in this process...
  16. Radia A, Yaser A, Ma X, Zhang J, Yang C, Dong Q, et al. Specific siRNA targeting receptor for advanced glycation end products (RAGE) decreases proliferation in human breast cancer cell lines. Int J Mol Sci. 2013;14:7959-78 pubmed publisher
    Receptor for Advanced Glycation End Products (RAGE) is an oncogenic trans-membranous receptor overexpressed in various human cancers. However, the role of RAGE in breast cancer development and proliferation is still unclear...
  17. Elangovan I, Thirugnanam S, Chen A, Zheng G, Bosland M, Kajdacsy Balla A, et al. Targeting receptor for advanced glycation end products (RAGE) expression induces apoptosis and inhibits prostate tumor growth. Biochem Biophys Res Commun. 2012;417:1133-8 pubmed publisher
    Expression of receptor for advanced glycation end products (RAGE) plays a key role in the progression of prostate cancer. However, the therapeutic potential of targeting RAGE expression in prostate cancer is not yet evaluated...
  18. Aydogan H, Kucukhuseyin O, Tekeli A, Isbir T. Associations of receptor for advanced glycation end products -374 T/A and Gly82 Ser and peroxisome proliferator-activated receptor gamma Pro12Ala polymorphisms in Turkish coronary artery disease patients. Genet Test Mol Biomarkers. 2012;16:134-7 pubmed publisher
    ..study was to investigate the individual and combined effects of receptor for advanced glycation end products (RAGE) -374T/A, RAGE Gly82Ser, and peroxisome proliferator-activated receptor gamma (PPAR-?) Pro12Ala polymorphisms on ..
  19. Krechler T, Jachymova M, Mestek O, Zak A, Zima T, Kalousova M. Soluble receptor for advanced glycation end-products (sRAGE) and polymorphisms of RAGE and glyoxalase I genes in patients with pancreas cancer. Clin Biochem. 2010;43:882-6 pubmed publisher
    ..The aim was to study sRAGE and polymorphisms of RAGE (AGER) and GLO genes in patients with pancreas cancer (PC)...
  20. Jing R, Cui M, Sun B, Yu J, Wang H. Tissue-specific expression profiling of receptor for advanced glycation end products and its soluble forms in esophageal and lung cancer. Genet Test Mol Biomarkers. 2010;14:355-61 pubmed publisher
    The receptor for advanced glycation end products (RAGE) interacts with several ligands and is involved in various human diseases...
  21. Suchankova P, Klang J, Cavanna C, Holm G, Nilsson S, Jonsson E, et al. Is the Gly82Ser polymorphism in the RAGE gene relevant to schizophrenia and the personality trait psychoticism?. J Psychiatry Neurosci. 2012;37:122-8 pubmed publisher
    The receptor for advanced glycation end products (RAGE) is the main receptor for S100B, an astrogial proinflammatory mediator that has been suggested to be involved in the pathophysiology of schizophrenia...
  22. Koch M, Chitayat S, Dattilo B, Schiefner A, Diez J, Chazin W, et al. Structural basis for ligand recognition and activation of RAGE. Structure. 2010;18:1342-52 pubmed publisher
    The receptor for advanced glycation end products (RAGE) is a pattern recognition receptor involved in inflammatory processes and is associated with diabetic complications, tumor outgrowth, and neurodegenerative disorders...
  23. Kerkeni M, Saïdi A, Bouzidi H, Ben Yahya S, Hammami M. Elevated serum levels of AGEs, sRAGE, and pentosidine in Tunisian patients with severity of diabetic retinopathy. Microvasc Res. 2012;84:378-83 pubmed publisher
    The advanced glycation end products (AGEs)-receptor for AGE (RAGE) axis activity are implicated in diabetic vascular complications...
  24. Daborg J, von Otter M, Sjölander A, Nilsson S, Minthon L, Gustafson D, et al. Association of the RAGE G82S polymorphism with Alzheimer's disease. J Neural Transm (Vienna). 2010;117:861-7 pubmed publisher
    ..the 82S allele of the functional single nucleotide polymorphism (SNP) G82S (rs2070600) in the RAGE-encoding gene AGER and risk of AD...
  25. Li R, Deng Y. [Expression of RECK, RAGE and MMP-9 in nasopharyngeal carcinoma and its significance]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2010;24:823-7 pubmed
    To investigate the expression and the relativity of RECK,RAGE and MMP-9 in nasopharyngeal carcinoma (NPC) tissues...
  26. Basta G, Del Turco S, Marchi F, Navarra T, Battaglia D, Mercuri A, et al. Elevated soluble receptor for advanced glycation end product levels in patients with acute coronary syndrome and positive cardiac troponin I. Coron Artery Dis. 2011;22:590-4 pubmed publisher
    ..323, P=0.0045) was found between sRAGE and cTnI levels in patients with NSTE-ACS. Plasma sRAGE levels are elevated in patients with NSTE-ACS with positive cTnI, suggesting that they could be related to myocardial cell damage. ..
  27. Hudson B, Moon Y, Kalea A, Khatri M, Marquez C, Schmidt A, et al. Association of serum soluble receptor for advanced glycation end-products with subclinical cerebrovascular disease: the Northern Manhattan Study (NOMAS). Atherosclerosis. 2011;216:192-8 pubmed publisher
    ..Taken together, these findings suggest sRAGE levels may be significantly influence by ethnicity. Further studies of sRAGE and stroke risk, particularly in minorities, are warranted. ..
  28. Ramasamy R, Yan S, Schmidt A. Receptor for AGE (RAGE): signaling mechanisms in the pathogenesis of diabetes and its complications. Ann N Y Acad Sci. 2011;1243:88-102 pubmed publisher
    The receptor for advanced glycation endproducts (RAGE) was first described as a signal transduction receptor for advanced glycation endproducts (AGEs), the products of nonenzymatic glycation and oxidation of proteins and lipids that ..
  29. Romero R, Chaiworapongsa T, Savasan Z, Hussein Y, Dong Z, Kusanovic J, et al. Clinical chorioamnionitis is characterized by changes in the expression of the alarmin HMGB1 and one of its receptors, sRAGE. J Matern Fetal Neonatal Med. 2012;25:558-67 pubmed publisher
    ..The receptor for advanced glycation end products (RAGE) can bind HMGB1...
  30. Jules J, Maiguel D, Hudson B. Alternative splicing of the RAGE cytoplasmic domain regulates cell signaling and function. PLoS ONE. 2013;8:e78267 pubmed publisher
    The Receptor for Advanced Glycation End-products (RAGE) is a multi-ligand receptor present on most cell types...
  31. Liang H, Zhong Y, Zhou S, Peng L. Knockdown of RAGE expression inhibits colorectal cancer cell invasion and suppresses angiogenesis in vitro and in vivo. Cancer Lett. 2011;313:91-8 pubmed publisher
    The receptor for advanced glycation end-products (RAGE) is a transmembrane receptor in cells, and the interaction of RAGE with ligands results in pro-inflammatory gene activation...
  32. Kim J, Park S, Lee M, Song Y, Han S, Kim S, et al. Plasma levels of soluble receptor for advanced glycation end products (sRAGE) and proinflammatory ligand for RAGE (EN-RAGE) are associated with carotid atherosclerosis in patients with peritoneal dialysis. Atherosclerosis. 2012;220:208-14 pubmed publisher
    ..sRAGE) exerts a protective effect on the development of atherosclerotic vascular complications by inhibiting RAGE-mediated inflammatory response...
  33. Zhu X, Jin L, Zou S, Shen Q, Jiang W, Lin W, et al. Immunohistochemical expression of RAGE and its ligand (S100A9) in cervical lesions. Cell Biochem Biophys. 2013;66:843-50 pubmed publisher
    Altered expressions of receptor for advanced glycation end-products (RAGE) and its ligand (S100A9) are observed in many cancers and play a key role in inflammation-associated cancer...
  34. Cui X, Chen H, Hou X, Wang S, Jayaram S, Zheng Z. Polymorphism of the RAGE affects the serum inflammatory levels and risk of ischemic stroke in a Chinese population. Cell Physiol Biochem. 2013;32:986-96 pubmed publisher
    ..The receptor for advanced glycation end products (RAGE) has been documented to involve in the pathogenic mechanisms of a variety of neurological diseases, including ..
  35. Kang R, Tang D, Livesey K, Schapiro N, Lotze M, Zeh H. The Receptor for Advanced Glycation End-products (RAGE) protects pancreatic tumor cells against oxidative injury. Antioxid Redox Signal. 2011;15:2175-84 pubmed publisher
    ..we investigated the effect of oxidative stress on activation of the Receptor for Advanced Glycation End-products (RAGE) and subsequent protection against H(2)O(2)-induced pancreatic tumor cell damage...
  36. Creagh Brown B, Quinlan G, Evans T, Burke Gaffney A. The RAGE axis in systemic inflammation, acute lung injury and myocardial dysfunction: an important therapeutic target?. Intensive Care Med. 2010;36:1644-56 pubmed publisher
    ..pathways that could offer a wider therapeutic window, such as the receptor for advanced glycation end-products (RAGE) and its ligands...
  37. Nakashima A, Carrero J, Qureshi A, Miyamoto T, Anderstam B, Barany P, et al. Effect of circulating soluble receptor for advanced glycation end products (sRAGE) and the proinflammatory RAGE ligand (EN-RAGE, S100A12) on mortality in hemodialysis patients. Clin J Am Soc Nephrol. 2010;5:2213-9 pubmed publisher
    ..In contrast, the RAGE ligand S100A12 (also known as EN-RAGE) contributes to inflammation and the development of atherosclerosis in animal ..
  38. Colhoun H, Betteridge D, Durrington P, Hitman G, Neil A, Livingstone S, et al. Total soluble and endogenous secretory receptor for advanced glycation end products as predictive biomarkers of coronary heart disease risk in patients with type 2 diabetes: an analysis from the CARDS trial. Diabetes. 2011;60:2379-85 pubmed publisher
    ..receptor for advanced glycation end products (sRAGE) likely comprise both a secreted isoform (esRAGE) and wild-type RAGE cleaved from the cell membrane...
  39. Kotani K, Caccavello R, Taniguchi N, Gugliucci A. Circulating soluble receptor for advanced glycation end products is inversely correlated to oxidized low-density lipoproteins in asymptomatic subjects. J Int Med Res. 2012;40:1878-83 pubmed
    ..for advanced glycation end products (sRAGE) exerts antiatherogenic effects as a decoy receptor that abolishes RAGE signalling. A previous study reported that oxidized low-density lipoprotein (oxLDL) can be one of the RAGE ligands...
  40. Sárkány Z, Ikonen T, Ferreira da Silva F, Saraiva M, Svergun D, Damas A. Solution structure of the soluble receptor for advanced glycation end products (sRAGE). J Biol Chem. 2011;286:37525-34 pubmed publisher
    The receptor for advanced glycation end products (RAGE) is a multiligand cell surface receptor involved in various human diseases, as it binds to numerous molecules and proteins that modulate the activity of other proteins...
  41. Ng Z, Kuppusamy U, Poh R, Tajunisah I, Koay A, Fong K, et al. Lack of association between Gly82Ser, 1704G/T and 2184A/G of RAGE gene polymorphisms and retinopathy susceptibility in Malaysian diabetic patients. Genet Mol Res. 2012;11:455-61 pubmed publisher
    ..We investigated the association of Gly82Ser, 1704G/T and 2184A/G polymorphisms in the RAGE gene with retinopathy in type 2 diabetic patients in Malaysia...
  42. Meghnani V, Vetter S, Leclerc E. RAGE overexpression confers a metastatic phenotype to the WM115 human primary melanoma cell line. Biochim Biophys Acta. 2014;1842:1017-27 pubmed publisher
    ..We have previously shown that the receptor for advanced glycation end products (RAGE) was up-regulated in late metastatic stages of melanoma patient samples and we hypothesized that up-regulation of ..
  43. Rai V, Maldonado A, Burz D, Reverdatto S, Yan S, Schmidt A, et al. Signal transduction in receptor for advanced glycation end products (RAGE): solution structure of C-terminal rage (ctRAGE) and its binding to mDia1. J Biol Chem. 2012;287:5133-44 pubmed publisher
    The receptor for advanced glycation end products (RAGE) is a multiligand cell surface macromolecule that plays a central role in the etiology of diabetes complications, inflammation, and neurodegeneration...
  44. Ma W, Rai V, Hudson B, Song F, Schmidt A, Barile G. RAGE binds C1q and enhances C1q-mediated phagocytosis. Cell Immunol. 2012;274:72-82 pubmed publisher
    b>RAGE, the multiligand receptor of the immunoglobulin superfamily of cell surface molecules, is implicated in innate and adaptive immunity...
  45. Jiao L, Taylor P, Weinstein S, Graubard B, Virtamo J, Albanes D, et al. Advanced glycation end products, soluble receptor for advanced glycation end products, and risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev. 2011;20:1430-8 pubmed publisher
    ..AGEs induce oxidative stress and inflammation via the receptor for AGEs (RAGE) and soluble RAGE (sRAGE) can neutralize the effects mediated by RAGE-ligand engagement...
  46. Guo W, Knight P, Raghavendran K. The receptor for advanced glycation end products and acute lung injury/acute respiratory distress syndrome. Intensive Care Med. 2012;38:1588-98 pubmed
    The receptor for advanced glycation end products (RAGE) is a pattern-recognition receptor and evolutionary member of the immunoglobulin superfamily that is involved in the host response to infection, injury, and inflammation...
  47. Moser B, Bekos C, Zimprich F, Nickl S, Klepetko W, Ankersmit J. The receptor for advanced glycation endproducts and its ligands in patients with myasthenia gravis. Biochem Biophys Res Commun. 2012;420:96-101 pubmed publisher
    ..The receptor for advanced glycation endproducts (RAGE) plays a role in the amplification of chronic inflammatory disorders and autoimmune diseases...
  48. Lin L, Zhong K, Sun Z, Wu G, Ding G. Receptor for advanced glycation end products (RAGE) partially mediates HMGB1-ERKs activation in clear cell renal cell carcinoma. J Cancer Res Clin Oncol. 2012;138:11-22 pubmed publisher
    To explore the expression of receptor for advanced glycation end products (RAGE) and high-mobility group box-1 (HMGB1) and their role in clear cell renal cell carcinoma (CCRCC) development and progression...
  49. Ohlmeier S, Mazur W, Salmenkivi K, Myllärniemi M, Bergmann U, Kinnula V. Proteomic studies on receptor for advanced glycation end product variants in idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease. Proteomics Clin Appl. 2010;4:97-105 pubmed publisher
    Proteomic screening revealed declined levels of the receptor for advanced glycation end products (RAGE) in human idiopathic pulmonary fibrosis (IPF)...
  50. Kang R, Tang D, Lotze M, Zeh H. RAGE regulates autophagy and apoptosis following oxidative injury. Autophagy. 2011;7:442-4 pubmed
    The receptor for advanced glycation end products (RAGE) plays a crucial role in several disease processes including diabetes, inflammation, and cancer...
  51. Pollreisz A, Hudson B, Chang J, Qu W, Cheng B, Papapanou P, et al. Receptor for advanced glycation endproducts mediates pro-atherogenic responses to periodontal infection in vascular endothelial cells. Atherosclerosis. 2010;212:451-6 pubmed publisher
    ..The receptor for advanced glycation endproducts (RAGE) regulates vascular inflammation and atherogenesis. We hypothesized that RAGE is involved in P...
  52. Balasubbu S, Sundaresan P, Rajendran A, Ramasamy K, Govindarajan G, Perumalsamy N, et al. Association analysis of nine candidate gene polymorphisms in Indian patients with type 2 diabetic retinopathy. BMC Med Genet. 2010;11:158 pubmed publisher
    ..Seven candidate genes (RAGE, PEDF, AKR1B1, EPO, HTRA1, ICAM and HFE) were chosen based on reported association with DR in the literature...
  53. Yamakawa N, Uchida T, Matthay M, Makita K. Proteolytic release of the receptor for advanced glycation end products from in vitro and in situ alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2011;300:L516-25 pubmed publisher
    Although the receptor for advanced glycation end products (RAGE) has been used as a biological marker of alveolar epithelial cell injury in clinical studies, the mechanism for release of soluble RAGE from lung epithelial cells has not ..
  54. Niu W, Qi Y, Wu Z, Liu Y, Zhu D, Jin W. A meta-analysis of receptor for advanced glycation end products gene: four well-evaluated polymorphisms with diabetes mellitus. Mol Cell Endocrinol. 2012;358:9-17 pubmed publisher
    Genetic association studies on the gene encoding receptor for advanced glycation end products (RAGE) and diabetes mellitus have reported conflicting results...
  55. Kang R, Tang D, Schapiro N, Loux T, Livesey K, Billiar T, et al. The HMGB1/RAGE inflammatory pathway promotes pancreatic tumor growth by regulating mitochondrial bioenergetics. Oncogene. 2014;33:567-77 pubmed publisher
    ..Here, we show that the receptor for advanced glycation endproducts (RAGE) and one of its primary ligands, high-mobility group box 1 (HMGB1), are required for optimal mitochondrial function ..
  56. Myles A, Viswanath V, Singh Y, Aggarwal A. Soluble receptor for advanced glycation endproducts is decreased in patients with juvenile idiopathic arthritis (ERA category) and inversely correlates with disease activity and S100A12 levels. J Rheumatol. 2011;38:1994-9 pubmed publisher
    ..g., S100A12) and triggers an inflammatory immune response. In contrast, soluble RAGE (sRAGE) acts as a decoy receptor and downmodulates inflammation...
  57. Gao J, Shao Y, Lai W, Ren H, Xu D. Association of polymorphisms in the RAGE gene with serum CRP levels and coronary artery disease in the Chinese Han population. J Hum Genet. 2010;55:668-75 pubmed publisher
    The role of an advanced glycation end product/receptor for advanced glycation end product (AGE/RAGE) system in the pathogenesis of coronary artery disease (CAD) is not fully understood...
  58. Kang R, Loux T, Tang D, Schapiro N, Vernon P, Livesey K, et al. The expression of the receptor for advanced glycation endproducts (RAGE) is permissive for early pancreatic neoplasia. Proc Natl Acad Sci U S A. 2012;109:7031-6 pubmed publisher
    ..Here we show that the receptor for advanced glycation endproducts (RAGE) is required for the activation of interleukin 6 (IL-6)-mediated mitochondrial signal transducers and activators of ..
  59. Ng Z, Kuppusamy U, Tajunisah I, Fong K, Koay A, Chua K. 2245G/A polymorphism of the receptor for advanced glycation end-products (RAGE) gene is associated with diabetic retinopathy in the Malaysian population. Br J Ophthalmol. 2012;96:289-92 pubmed publisher
    The receptor for advanced glycation end-products (RAGE) has been implicated in the pathogenesis of diabetic microvascular complications...
  60. Mosquera J. [Role of the receptor for advanced glycation end products (RAGE) in inflammation]. Invest Clin. 2010;51:257-68 pubmed
    The receptor for advanced glycation end products (RAGE) is a transmembrane protein on the cellular surface that recognizes tridimensional molecules, instead of aminoacid sequences, making this molecule capable of interacting with diverse ..
  61. Buckley S, Medina C, Kasper M, Ehrhardt C. Interplay between RAGE, CD44, and focal adhesion molecules in epithelial-mesenchymal transition of alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2011;300:L548-59 pubmed publisher
    ..The receptor for advanced glycation end-products (RAGE) has been suggested to maintain lung homeostasis by mediating cell adhesion, while the family of ezrin/radixin/..
  62. Wang X, Cui E, Zeng H, Hua F, Wang B, Mao W, et al. RAGE genetic polymorphisms are associated with risk, chemotherapy response and prognosis in patients with advanced NSCLC. PLoS ONE. 2012;7:e43734 pubmed publisher
    To explore the association between genetic polymorphisms of the receptor for advanced glycation end-products (RAGE) and susceptibility, chemotherapy response rate and prognosis of non-small cell lung cancer (NSCLC)...
  63. Prasad P, Tiwari A, Kumar K, Ammini A, Gupta A, Gupta R, et al. Association analysis of ADPRT1, AKR1B1, RAGE, GFPT2 and PAI-1 gene polymorphisms with chronic renal insufficiency among Asian Indians with type-2 diabetes. BMC Med Genet. 2010;11:52 pubmed publisher
    ..ADPRT1), aldo-keto reductase family 1 member B1 (AKR1B1), receptor for advanced glycation end-products (RAGE), glutamine:fructose-6-phosphate amidotransferase-2 (GFPT2), and plasminogen activator inhibitor-1 (PAI-1) genes ..
  64. Xiong F, Leonov S, Howard A, Xiong S, Zhang B, Mei L, et al. Receptor for advanced glycation end products (RAGE) prevents endothelial cell membrane resealing and regulates F-actin remodeling in a beta-catenin-dependent manner. J Biol Chem. 2011;286:35061-70 pubmed publisher
    Receptor for advanced glycation end products (RAGE), an immunoglobin superfamily cell surface receptor, contributes to the vascular pathology associated with multiple disorders, including Alzheimer disease (AD), diabetic complications, ..
  65. Ruan B, Li X, Winkler A, Cunningham K, Kuai J, Greco R, et al. Complement C3a, CpG oligos, and DNA/C3a complex stimulate IFN-? production in a receptor for advanced glycation end product-dependent manner. J Immunol. 2010;185:4213-22 pubmed publisher
    The receptor for advanced glycation end products (RAGE) is a multiligand transmembrane receptor implicated in a number of diseases including autoimmune diseases...
  66. Ng Z, Kuppusamy U, Tajunisah I, Fong K, Chua K. Association analysis of -429T/C and -374T/A polymorphisms of receptor of advanced glycation end products (RAGE) gene in Malaysian with type 2 diabetic retinopathy. Diabetes Res Clin Pract. 2012;95:372-7 pubmed publisher
    Conflicting results have been reported in different populations on the association between two particular RAGE gene polymorphisms (-429T/C and -374T/A) and retinopathy in diabetic patients...
  67. Glasnović A, Cvija H, Stojic M, Tudorić Đeno I, Ivcevic S, Romic D, et al. Decreased level of sRAGE in the cerebrospinal fluid of multiple sclerosis patients at clinical onset. Neuroimmunomodulation. 2014;21:226-33 pubmed publisher
    Receptor for advanced glycation end products (RAGE) ligands/RAGE interactions have been proposed to have a pathogenic role in neuroinflammatory disorders...
  68. Nin J, Jorsal A, Ferreira I, Schalkwijk C, Prins M, Parving H, et al. Higher plasma soluble Receptor for Advanced Glycation End Products (sRAGE) levels are associated with incident cardiovascular disease and all-cause mortality in type 1 diabetes: a 12-year follow-up study. Diabetes. 2010;59:2027-32 pubmed publisher
    ..036). Higher levels of sRAGE are associated with incident fatal and nonfatal CVD and all-cause mortality in individuals with type 1 diabetes. sRAGE-associated renal dysfunction may partially explain this association. ..
  69. Al Mesallamy H, Hammad L, El Mamoun T, Khalil B. Role of advanced glycation end product receptors in the pathogenesis of diabetic retinopathy. J Diabetes Complications. 2011;25:168-74 pubmed publisher
    Advanced glycation end products (AGEs) and the interaction with their receptors (RAGE) play an important role in the pathogenesis of diabetic retinopathy (DR)...
  70. Soler Artigas M, Wain L, Repapi E, Obeidat M, Sayers I, Burton P, et al. Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function. Am J Respir Crit Care Med. 2011;184:786-95 pubmed publisher
    ..To test association with COPD of variants at five loci (TNS1, GSTCD, HTR4, AGER, and THSD4) and to evaluate joint effects on lung function and COPD of these single-nucleotide polymorphisms (SNPs),..
  71. Jiao L, Weinstein S, Albanes D, Taylor P, Graubard B, Virtamo J, et al. Evidence that serum levels of the soluble receptor for advanced glycation end products are inversely associated with pancreatic cancer risk: a prospective study. Cancer Res. 2011;71:3582-9 pubmed publisher
    ..during hyperglycemia and elicit oxidative stress and inflammation through interaction with the receptor for AGEs (RAGE)...
  72. Xu X, Gao H, Zhang W, Abuduhadeer X, Wang Y. Clinical significance of immunogenic cell death biomarker rage and early growth response 1 in human primary gastric adenocarcinoma. Int J Immunopathol Pharmacol. 2013;26:485-93 pubmed
    The receptor for advanced glycation end products (RAGE), a pattern recognition receptor that binds multiple ligands derived from a damaged cell environment, contributes to multiple pathologies including cancer...
  73. Kang P, Tian C, Jia C. Association of RAGE gene polymorphisms with type 2 diabetes mellitus, diabetic retinopathy and diabetic nephropathy. Gene. 2012;500:1-9 pubmed publisher
    A meta-analysis was performed to assess the associations of the receptor for advanced glycation end products (RAGE) gene polymorphisms [Gly82Ser (rs2070600), 1704G/T (rs184003), 429T/C (rs1800625)] with type 2 diabetes mellitus (T2DM), ..
  74. Meloche J, Paulin R, Courboulin A, Lambert C, Barrier M, Bonnet P, et al. RAGE-dependent activation of the oncoprotein Pim1 plays a critical role in systemic vascular remodeling processes. Arterioscler Thromb Vasc Biol. 2011;31:2114-24 pubmed publisher
    ..Recently, the activation of the advanced glycation endproducts receptor (RAGE) has been shown to promote VSMC proliferation and resistance to apoptosis in VRD in a signal transducer and ..
  75. Zhu P, Ren M, Yang C, Hu Y, Ran J, Yan L. Involvement of RAGE, MAPK and NF-?B pathways in AGEs-induced MMP-9 activation in HaCaT keratinocytes. Exp Dermatol. 2012;21:123-9 pubmed publisher
    ..Furthermore, receptor for advanced glycation end products (RAGE) was expressed in keratinocytes, and incubation with AGE-BSA resulted in a significant upregulation of RAGE ..
  76. Park H, Baek J, Shin W, Kim D, Jang S, Shin D, et al. Soluble receptor of advanced glycated endproducts is associated with plaque vulnerability in patients with acute myocardial infarction. Circ J. 2011;75:1685-90 pubmed
    ..98; 95%CI, 1.18-7.55; P = 0.021) and CRP ? 3.0 mg/L (OR, 3.08; 95%CI, 1.25-7.59; P = 0.015). An elevated plasma level of sRAGE might be independently associated with plaque vulnerability, as well as MMP-9, in patients with AMI. ..
  77. Wei W, Lampe L, Park S, Vangara B, Waldo G, Cabantous S, et al. Disulfide bonds within the C2 domain of RAGE play key roles in its dimerization and biogenesis. PLoS ONE. 2012;7:e50736 pubmed publisher
    The receptor for advanced glycation end products (RAGE) on the cell surface transmits inflammatory signals...
  78. Boiocchi C, Bozzini S, Buzzi M, Schirinzi S, Zorzetto M, Pelissero G, et al. Age of onset of myocardial infarction: is promoter polymorphism of the RAGE gene implicated?. Rejuvenation Res. 2011;14:67-73 pubmed publisher
    Receptor for advanced glycation endproducts (RAGE) is a cell-surface molecule member of the immunoglobulin superfamily and engages differing ligands relevant to distinct processes...
  79. Xu X, Abuduhadeer X, Zhang W, Li T, Gao H, Wang Y. Knockdown of RAGE inhibits growth and invasion of gastric cancer cells. Eur J Histochem. 2013;57:e36 pubmed publisher
    The receptor for advanced glycation endproducts (RAGE) is an oncogenic trans-membranous receptor, which is overexpressed in multiple human cancers. However, the role of RAGE in gastric cancer is still elusive...
  80. Däbritz J, Friedrichs F, Weinhage T, Hampe J, Kucharzik T, Lugering A, et al. The functional -374T/A polymorphism of the receptor for advanced glycation end products may modulate Crohn's disease. Am J Physiol Gastrointest Liver Physiol. 2011;300:G823-32 pubmed publisher
    The receptor for advanced glycation end products (RAGE) is involved in innate immune mechanisms...
  81. Agostoni P, Banfi C, Brioschi M, Magri D, Sciomer S, Berna G, et al. Surfactant protein B and RAGE increases in the plasma during cardiopulmonary bypass: a pilot study. Eur Respir J. 2011;37:841-7 pubmed publisher
    Surfactant derived protein B (SPB) and plasma receptor for advanced glycation end products (RAGE) have been proposed as markers of lung injury...
  82. Lu W, Feng B. The -374A allele of the RAGE gene as a potential protective factor for vascular complications in type 2 diabetes: a meta-analysis. Tohoku J Exp Med. 2010;220:291-7 pubmed
    The receptor for advanced glycation end products (RAGE) is a multi-ligand member of the immunoglobulin superfamily and may be involved in the development of diabetic vascular complications...