adrenoleukodystrophy

Summary

Gene Symbol: adrenoleukodystrophy
Description: ATP binding cassette subfamily D member 1
Alias: ABC42, ALD, ALDP, AMN, ATP-binding cassette sub-family D member 1, ATP-binding cassette, sub-family D (ALD), member 1, adrenoleukodystrophy protein
Species: human
Products:     adrenoleukodystrophy

Top Publications

  1. Mosser J, Douar A, Sarde C, Kioschis P, Feil R, Moser H, et al. Putative X-linked adrenoleukodystrophy gene shares unexpected homology with ABC transporters. Nature. 1993;361:726-30 pubmed
    b>Adrenoleukodystrophy (ALD) is an X-linked disease affecting 1/20,000 males either as cerebral ALD in childhood or as adrenomyeloneuropathy (AMN) in adults...
  2. Migeon B, Moser H, Moser A, Axelman J, Sillence D, Norum R. Adrenoleukodystrophy: evidence for X linkage, inactivation, and selection favoring the mutant allele in heterozygous cells. Proc Natl Acad Sci U S A. 1981;78:5066-70 pubmed
    Skin fibroblasts of human males affected with adrenoleukodystrophy (ALD) have previously been shown to be abnormal with respect to C26 fatty acid content...
  3. Mosser J, Lutz Y, Stoeckel M, Sarde C, Kretz C, Douar A, et al. The gene responsible for adrenoleukodystrophy encodes a peroxisomal membrane protein. Hum Mol Genet. 1994;3:265-71 pubmed
    ..Immunofluorescence and immunoelectron microscopy showed that the adrenoleukodystrophy protein (ALDP) is associated with the peroxisomal membrane...
  4. Eichler E, Budarf M, Rocchi M, Deaven L, Doggett N, Baldini A, et al. Interchromosomal duplications of the adrenoleukodystrophy locus: a phenomenon of pericentromeric plasticity. Hum Mol Genet. 1997;6:991-1002 pubmed
    A 9.7 kb segment encompassing exons 7-10 of the adrenoleukodystrophy (ALD) locus of the X chromosome has duplicated to specific locations near the pericentromeric regions of human chromosomes 2p11,10p11, 16p11 and 22q11...
  5. Takano H, Koike R, Onodera O, Sasaki R, Tsuji S. Mutational analysis and genotype-phenotype correlation of 29 unrelated Japanese patients with X-linked adrenoleukodystrophy. Arch Neurol. 1999;56:295-300 pubmed
    X-linked adrenoleukodystrophy (ALD) is an inherited disease characterized by progressive neurologic dysfunction, occasionally associated with adrenal insufficiency...
  6. Takahashi N, Morita M, Maeda T, Harayama Y, Shimozawa N, Suzuki Y, et al. Adrenoleukodystrophy: subcellular localization and degradation of adrenoleukodystrophy protein (ALDP/ABCD1) with naturally occurring missense mutations. J Neurochem. 2007;101:1632-43 pubmed
    ..The encoded adrenoleukodystrophy protein (ALDP/ABCD1) is a half-size peroxisomal ATP-binding cassette protein of 745 amino acids in humans...
  7. van Roermund C, Visser W, IJlst L, van Cruchten A, Boek M, Kulik W, et al. The human peroxisomal ABC half transporter ALDP functions as a homodimer and accepts acyl-CoA esters. FASEB J. 2008;22:4201-8 pubmed publisher
    ..The most frequent peroxisomal disorder is X-linked adrenoleukodystrophy (X-ALD), which is caused by mutations in the ABCD1 gene...
  8. Matsukawa T, Asheuer M, Takahashi Y, Goto J, Suzuki Y, Shimozawa N, et al. Identification of novel SNPs of ABCD1, ABCD2, ABCD3, and ABCD4 genes in patients with X-linked adrenoleukodystrophy (ALD) based on comprehensive resequencing and association studies with ALD phenotypes. Neurogenetics. 2011;12:41-50 pubmed publisher
    b>Adrenoleukodystrophy (ALD) is an X-linked disorder affecting primarily the white matter of the central nervous system occasionally accompanied by adrenal insufficiency...
  9. Lachtermacher M, Seuanez H, Moser A, Moser H, Smith K. Determination of 30 X-linked adrenoleukodystrophy mutations, including 15 not previously described. Hum Mutat. 2000;15:348-53 pubmed
    X-linked Adrenoleukodystrophy (X-ALD) is the most frequent peroxisomal disease. It mainly involves the nervous system white matter, adrenal cortex and testes. Several distinct clinical phenotypes are known...

More Information

Publications107 found, 100 shown here

  1. Kemp S, Pujol A, Waterham H, van Geel B, Boehm C, Raymond G, et al. ABCD1 mutations and the X-linked adrenoleukodystrophy mutation database: role in diagnosis and clinical correlations. Hum Mutat. 2001;18:499-515 pubmed
    X-linked adrenoleukodystrophy (X-ALD) is caused by mutations in the ABCD1 gene, which encodes a peroxisomal ABC half-transporter (ALDP) involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome...
  2. Pan H, Xiong H, Wu Y, Zhang Y, Bao X, Jiang Y, et al. ABCD1 gene mutations in Chinese patients with X-linked adrenoleukodystrophy. Pediatr Neurol. 2005;33:114-20 pubmed
    X-linked adrenoleukodystrophy is a neurodegenerative disorder caused by mutations in the adrenoleukodystrophy (ALD) protein gene ABCD1...
  3. Hillebrand M, Verrier S, Ohlenbusch A, Schäfer A, Soling H, Wouters F, et al. Live cell FRET microscopy: homo- and heterodimerization of two human peroxisomal ABC transporters, the adrenoleukodystrophy protein (ALDP, ABCD1) and PMP70 (ABCD3). J Biol Chem. 2007;282:26997-7005 pubmed
    The adrenoleukodystrophy protein (ALDP) and the 70-kDa peroxisomal membrane protein (PMP70) are half-ATP-binding cassette (ABC) transporters in the mammalian peroxisome membrane...
  4. Kumar N, Taneja K, Kumar A, Nayar D, Taneja B, Aneja S, et al. Novel mutation in ATP-binding domain of ABCD1 gene in adrenoleukodystrophy. J Genet. 2010;89:473-7 pubmed
  5. Salsano E, Tabano S, Sirchia S, Colapietro P, Castellotti B, Gellera C, et al. Preferential expression of mutant ABCD1 allele is common in adrenoleukodystrophy female carriers but unrelated to clinical symptoms. Orphanet J Rare Dis. 2012;7:10 pubmed publisher
    Approximately 20% of adrenoleukodystrophy (X-ALD) female carriers may develop clinical manifestations, typically consisting of progressive spastic gait, sensory deficits and bladder dysfunctions...
  6. Berger J, Molzer B, Fae I, Bernheimer H. X-linked adrenoleukodystrophy (ALD): a novel mutation of the ALD gene in 6 members of a family presenting with 5 different phenotypes. Biochem Biophys Res Commun. 1994;205:1638-43 pubmed
    Fragments of the adrenoleukodystrophy (ALD) cDNA from a patient with adolescent ALD were amplified by polymerase chain reaction and subcloned...
  7. Sarde C, Mosser J, Kioschis P, Kretz C, Vicaire S, Aubourg P, et al. Genomic organization of the adrenoleukodystrophy gene. Genomics. 1994;22:13-20 pubmed
    b>Adrenoleukodystrophy (ALD), the most frequent peroxisomal disorder, is a severe neurodegenerative disease associated with an impairment of very long chain fatty acids beta-oxidation...
  8. Krasemann E, Meier V, Korenke G, Hunneman D, Hanefeld F. Identification of mutations in the ALD-gene of 20 families with adrenoleukodystrophy/adrenomyeloneuropathy. Hum Genet. 1996;97:194-7 pubmed
    b>Adrenoleukodystrophy (ALD), an X-linked inherited metabolic disorder, is the most frequent inborn peroxisomal disease. It leads to demyelination in the central and peripheral nervous system...
  9. Shukla P, Gupta N, Kabra M, Ghosh M, Sharma R, Gupta A, et al. Three novel variants in X-linked adrenoleukodystrophy. J Child Neurol. 2009;24:857-60 pubmed publisher
    ..neurological disorder caused by mutations in the ABCD1 gene (located on chromosome Xq28) encoding adrenoleukodystrophy protein which is involved in the transport of substrates from the cytoplasm into the peroxisomal lumen...
  10. Wiesinger C, Kunze M, Regelsberger G, Forss Petter S, Berger J. Impaired very long-chain acyl-CoA ?-oxidation in human X-linked adrenoleukodystrophy fibroblasts is a direct consequence of ABCD1 transporter dysfunction. J Biol Chem. 2013;288:19269-79 pubmed publisher
    ..by mutations in the ABCD1 gene encoding the peroxisomal ATP-binding cassette (ABC) transporter ABCD1 (adrenoleukodystrophy protein, ALDP)...
  11. Ligtenberg M, Kemp S, Sarde C, van Geel B, Kleijer W, Barth P, et al. Spectrum of mutations in the gene encoding the adrenoleukodystrophy protein. Am J Hum Genet. 1995;56:44-50 pubmed
    X-linked adrenoleukodystrophy (ALD) has been associated with mutations in a gene encoding an ATP-binding transporter, which is located in the peroxisomal membrane. Deficiency of the gene leads to impaired peroxisomal beta-oxidation...
  12. Feigenbaum V, Lombard Platet G, Guidoux S, Sarde C, Mandel J, Aubourg P. Mutational and protein analysis of patients and heterozygous women with X-linked adrenoleukodystrophy. Am J Hum Genet. 1996;58:1135-44 pubmed
    X-linked adrenoleukodystrophy (ALD), a neurodegenerative disorder associated with impaired beta-oxidation of very-long-chain fatty acids (VLCFA), is due to mutations in a gene encoding a peroxisomal ATP-binding cassette (ABC) transporter (..
  13. Liu L, Janvier K, Berteaux Lecellier V, Cartier N, Benarous R, Aubourg P. Homo- and heterodimerization of peroxisomal ATP-binding cassette half-transporters. J Biol Chem. 1999;274:32738-43 pubmed
    Mammalian peroxisomal proteins adrenoleukodystrophy protein (ALDP), adrenoleukodystrophy-related protein (ALDRP), and 70-kDa peroxisomal protein (PMP70) belong to the superfamily of ATP-binding cassette (ABC) transporters...
  14. Dvorakova L, Storkanova G, Unterrainer G, Hujová J, Kmoch S, Zeman J, et al. Eight novel ABCD1 gene mutations and three polymorphisms in patients with X-linked adrenoleukodystrophy: The first polymorphism causing an amino acid exchange. Hum Mutat. 2001;18:52-60 pubmed
    ..Expression studies revealed that only K217E is a deleterious mutation, because a plasmid encoding ALDP with K217E was ineffective in the restoration of defective beta-oxidation in X-ALD fibroblasts...
  15. Kok F, Neumann S, Sarde C, Zheng S, Wu K, Wei H, et al. Mutational analysis of patients with X-linked adrenoleukodystrophy. Hum Mutat. 1995;6:104-15 pubmed
    b>Adrenoleukodystrophy (ALD) is an X-linked neurodegenerative disorder characterized by elevated very long chain fatty acid (VLCFA) levels, reduced activity of peroxisomal VLCFA-CoA ligase, and variable phenotypic expression...
  16. Woudenberg J, Rembacz K, van den Heuvel F, Woudenberg Vrenken T, Buist Homan M, Geuken M, et al. Caveolin-1 is enriched in the peroxisomal membrane of rat hepatocytes. Hepatology. 2010;51:1744-53 pubmed publisher
    ..with peroxisomal marker proteins (catalase, the 70 kDa peroxisomal membrane protein PMP70, the adrenoleukodystrophy protein ALDP, Pex14p, and the bile acid-coenzyme A:amino acid N-acyltransferase BAAT) in rat hepatocytes...
  17. Baarine M, Ragot K, Genin E, El Hajj H, Trompier D, Andreoletti P, et al. Peroxisomal and mitochondrial status of two murine oligodendrocytic cell lines (158N, 158JP): potential models for the study of peroxisomal disorders associated with dysmyelination processes. J Neurochem. 2009;111:119-31 pubmed publisher
    ..protein), oligodendrocyte (CNPase and myelin oligodendrocyte glycoprotein), and peroxisomal markers [adrenoleukodystrophy protein, PMP70, acyl-CoA oxidase 1 (ACOX1), l-peroxisomal bifunctional enzyme, and catalase]...
  18. Mak C, Lam K, Ma O, Tso A, Tam S. Novel insertion 496_497insG creating a stop codon D194X in a Chinese family with X-Linked adrenoleukodystrophy. Horm Res. 2005;63:1-5 pubmed
    X-linked adrenoleukodystrophy (XALD, MIM 300100), the commonest inherited peroxisomal disorder, is characterized by central nervous system demyelination, primary adrenal failure and the systemic accumulation of saturated very long chain ..
  19. Baarine M, Andreoletti P, Athias A, Nury T, Zarrouk A, Ragot K, et al. Evidence of oxidative stress in very long chain fatty acid--treated oligodendrocytes and potentialization of ROS production using RNA interference-directed knockdown of ABCD1 and ACOX1 peroxisomal proteins. Neuroscience. 2012;213:1-18 pubmed publisher
    X-linked adrenoleukodystrophy (X-ALD) and pseudo neonatal adrenoleukodystrophy (P-NALD) are neurodegenerative demyelinating diseases resulting from the functional loss of the peroxisomal ATP-binding cassette transporter D (ABCD1) and from ..
  20. Jia Z, Pei Z, Li Y, Wei L, Smith K, Watkins P. X-linked adrenoleukodystrophy: role of very long-chain acyl-CoA synthetases. Mol Genet Metab. 2004;83:117-27 pubmed
    The principal biochemical abnormality in the neurodegenerative disorder X-linked adrenoleukodystrophy (X-ALD) is elevated plasma and tissue levels of very long-chain fatty acids (VLCFA)...
  21. Zolman B, Silva I, Bartel B. The Arabidopsis pxa1 mutant is defective in an ATP-binding cassette transporter-like protein required for peroxisomal fatty acid beta-oxidation. Plant Physiol. 2001;127:1266-78 pubmed
    ..PXA1 encodes a predicted peroxisomal ATP-binding cassette transporter that is 42% identical to the human adrenoleukodystrophy (ALD) protein, which is defective in patients with the demyelinating disorder X-linked ALD...
  22. Di Benedetto R, Denti M, Salvati S, Attorri L, Di Biase A. PMP70 knock-down generates oxidative stress and pro-inflammatory cytokine production in C6 glial cells. Neurochem Int. 2009;54:37-42 pubmed publisher
    ..of hexacosenoic acid in cholesterol ester fraction, indicated an overlapping function of PMP70 with adrenoleukodystrophy protein (ALDP), the peroxisomal half-transporters involved in X-linked adrenoleukodystrophy (X-ALD)...
  23. López Erauskin J, Galino J, Ruiz M, Cuezva J, Fabregat I, Cacabelos D, et al. Impaired mitochondrial oxidative phosphorylation in the peroxisomal disease X-linked adrenoleukodystrophy. Hum Mol Genet. 2013;22:3296-305 pubmed publisher
    X-linked adrenoleukodystrophy (X-ALD) is an inherited metabolic disorder of the nervous system characterized by axonopathy in spinal cords and/or cerebral demyelination, adrenal insufficiency and accumulation of very long-chain fatty ..
  24. Tokushige K, Hyogo H, Nakajima T, Ono M, Kawaguchi T, Honda K, et al. Hepatocellular carcinoma in Japanese patients with nonalcoholic fatty liver disease and alcoholic liver disease: multicenter survey. J Gastroenterol. 2016;51:586-96 pubmed publisher
    ..nonviral liver disease, especially with nonalcoholic fatty liver disease (NAFLD-HCC) and alcoholic liver disease (ALD-HCC), has been increasing. Clarification of the clinical features of NAFLD-HCC and ALD-HCC is needed...
  25. Yan B, Liu S, Heng Y, Yang Y, Yu Y, Wen K. Band Offset Measurements in Atomic-Layer-Deposited Al2O3/Zn0.8Al0.2O Heterojunction Studied by X-ray Photoelectron Spectroscopy. Nanoscale Res Lett. 2017;12:363 pubmed publisher
    ..and zinc aluminum oxide (Zn x Al1-x O) thin films were deposited by atomic layer deposition (ALD). The microstructure and optical band gaps (E g ) of the Zn x Al1-x O (0...
  26. Bambino K, Zhang C, Austin C, Amarasiriwardena C, Arora M, Chu J, et al. Inorganic arsenic causes fatty liver and interacts with ethanol to cause alcoholic liver disease in zebrafish. Dis Model Mech. 2018;11: pubmed publisher
    ..of iAs to FLD using zebrafish and tested the interaction with ethanol to cause alcoholic liver disease (ALD)...
  27. Okamoto T, Kawaguchi K, Watanabe S, Agustina R, Ikejima T, Ikeda K, et al. Characterization of human ATP-binding cassette protein subfamily D reconstituted into proteoliposomes. Biochem Biophys Res Commun. 2018;496:1122-1127 pubmed publisher
    ..Furthermore, ABCD1‒4 were found to possess an equal levels of acyl-CoA thioesterase activity. Proteoliposomes is expected to be an aid in the further biochemical characterization of ABCD transporters. ..
  28. Lee A, Asahina K, Okamoto T, Kawaguchi K, Kostsin D, Kashiwayama Y, et al. Role of NH2-terminal hydrophobic motif in the subcellular localization of ATP-binding cassette protein subfamily D: common features in eukaryotic organisms. Biochem Biophys Res Commun. 2014;453:612-8 pubmed publisher
    ..These results suggest that the role of the NH2-terminal H0 motif in organelle targeting is widely conserved in living organisms. ..
  29. Wilson C, Murphy L, Leslie J, Kendrick S, French J, Fox C, et al. Ubiquitin C-terminal hydrolase 1: A novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease. J Hepatol. 2015;63:1421-8 pubmed publisher
    ..Increased UCHL1 expression was confirmed in human HSC and in an alcoholic liver disease (ALD) patient liver...
  30. Leßmeier L, Pfeifenschneider J, Carnicer M, Heux S, Portais J, Wendisch V. Production of carbon-13-labeled cadaverine by engineered Corynebacterium glutamicum using carbon-13-labeled methanol as co-substrate. Appl Microbiol Biotechnol. 2015;99:10163-76 pubmed publisher
    ..Deletion of the endogenous aldehyde dehydrogenase genes ald and fadH prevented methanol oxidation to carbon dioxide and formaldehyde detoxification via the linear formaldehyde ..
  31. Zhang A, Yan G, Zhou X, Wang Y, Han Y, Guan Y, et al. High resolution metabolomics technology reveals widespread pathway changes of alcoholic liver disease. Mol Biosyst. 2016;12:262-73 pubmed publisher
    Alcoholic liver disease (ALD) is a significant cause of death and morbidity. However little is known regarding the widespread pathway changes of ALD disorder...
  32. Qin C, Cao J, Chen J, Dai G, Wu T, Chen Y, et al. Improvement of electrochemical performance of nickel rich LiNi0.6Co0.2Mn0.2O2 cathode active material by ultrathin TiO2 coating. Dalton Trans. 2016;45:9669-75 pubmed publisher
    ..6Co0.2Mn0.2O2 cathode material has been surface-modified by coating with ultrathin TiO2via atomic layer deposition (ALD) technology to improve the electrochemical performance of LiNi0.6Co0.2Mn0.2O2 cathodes for lithium ion batteries...
  33. Zheng Z, Gelling R. Attenuation of Carbon Tetrachloride-Induced Hepatic Toxicity by a Dietary Supplement. J Diet Suppl. 2017;14:121-131 pubmed
    Advanced liver disease (ALD) is often characterized with overt malnutrition and liver fibrosis...
  34. Jin H, Lian N, Bian M, Zhang C, Chen X, Shao J, et al. Oroxylin A prevents alcohol-induced hepatic steatosis through inhibition of hypoxia inducible factor 1alpha. Chem Biol Interact. 2018;285:14-20 pubmed publisher
    ..Oroxylin A modulation of HIF-1α level may represent a therapeutic remedy for ALD.
  35. Mitchell P, Steenstrup T, Hannon K. Expression of fibroblast growth factor family during postnatal skeletal muscle hypertrophy. J Appl Physiol (1985). 1999;86:313-9 pubmed
    ..After 2 or 11 days of weighted stretch, anterior latissimus dorsi (ALD) muscles were, on average, 34 (P < 0.01) and 85% (P < 0...
  36. Pyeon J, Kim S, Jeong D, Baek S, Kang C, Kim J, et al. Wafer-scale growth of MoS2 thin films by atomic layer deposition. Nanoscale. 2016;8:10792-8 pubmed publisher
    ..Here, we demonstrate the atomic layer deposition (ALD) of MoS2 films with Mo(CO)6 and H2S as the Mo and S precursors, respectively...
  37. Fukuta M, Ono A, Nawa Y, Inami W, Shen L, Kawata Y, et al. Cell structure imaging with bright and homogeneous nanometric light source. J Biophotonics. 2017;10:503-510 pubmed publisher
    ..A zinc oxide (ZnO) luminescent thin film was fabricated by atomic layer deposition (ALD) to produce the nanoscale light source...
  38. Abenavoli L, Masarone M, Federico A, Rosato V, Dallio M, Loguercio C, et al. Alcoholic Hepatitis: Pathogenesis, Diagnosis and Treatment. Rev Recent Clin Trials. 2016;11:159-66 pubmed
    Alcohol represents the oldest substance of abuse known and Alcoholic Liver Disease (ALD) is the most common cause of chronic liver disease worldwide...
  39. Gupta K, Donahue D, Sandoval Cooper M, Castellino F, Ploplis V. Plasminogen Activator Inhibitor-1 Protects Mice Against Cardiac Fibrosis by Inhibiting Urokinase-type Plasminogen Activator-mediated Plasminogen Activation. Sci Rep. 2017;7:365 pubmed publisher
    ..An Angiotensin II (AngII)-aldosterone (Ald) infusion mouse model of hypertension was utilised in this study...
  40. Takeuchi M, Takino J, Sakasai Sakai A, Takata T, Tsutsumi M. Toxic AGE (TAGE) Theory for the Pathophysiology of the Onset/Progression of NAFLD and ALD. Nutrients. 2017;9: pubmed publisher
    Non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) are among the most common causes of chronic liver diseases in the westernized world...
  41. Aggarwal K, Agarwal A, Katoch D, Sharma M, Gupta V. Optical coherence tomography angiography features of acute macular neuroretinopathy in dengue fever. Indian J Ophthalmol. 2017;65:1235-1238 pubmed publisher
    ..OCT showed hyperreflectivity in various layers, suggestive of acute macular neuroretinopathy (AMN). OCTA showed disruption of retinal capillary plexuses...
  42. Ivashkin V, Maevskaya M, Kobalava Z, Uspenskiy Y, Fominih J, Rozanov A, et al. Open-label study of ademetionine for the treatment of intrahepatic cholestasis associated with alcoholic liver disease. Minerva Gastroenterol Dietol. 2018;64:208-219 pubmed publisher
    ..biochemical markers of intrahepatic cholestasis (IHC) was investigated in subjects with alcoholic liver disease (ALD) and compensated liver function...
  43. Yamada T, Shinnoh N, Taniwaki T, Ohyagi Y, Asahara H, Horiuchi -, et al. Lovastatin does not correct the accumulation of very long-chain fatty acids in tissues of adrenoleukodystrophy protein-deficient mice. J Inherit Metab Dis. 2000;23:607-14 pubmed
    ..The effects of lovastatin on the accumulation of VLCFA in tissues of adrenoleukodystrophy protein (ALDP)-deficient mice were assessed. ALDP-deficient mice were fed chow with 0.01-0...
  44. Walterfang M, O Donovan J, Fahey M, Velakoulis D. The neuropsychiatry of adrenomyeloneuropathy. CNS Spectr. 2007;12:696-701 pubmed
    While the adult form of adrenoleukodystrophy (ALD) has been associated with an elevated rate of affective disturbance, the myeloneuropathic form of the disease known as adrenomyeloneuropathy (AMN) has been associated with only occasional ..
  45. Amorosi C, Myskova H, Monti M, Argaraña C, Morita M, Kemp S, et al. X-linked adrenoleukodystrophy: molecular and functional analysis of the ABCD1 gene in Argentinean patients. PLoS ONE. 2012;7:e52635 pubmed publisher
    X-linked adrenoleukodystrophy (X-ALD) is an inherited metabolic disease associated with mutations in the ABCD1 gene that encodes an ATP-binding cassette transporter protein, ALDP...
  46. Shaib W, Goodman M, Chen Z, Kim S, Brutcher E, Bekaii Saab T, et al. Incidence and Survival of Appendiceal Mucinous Neoplasms: A SEER Analysis. Am J Clin Oncol. 2017;40:569-573 pubmed publisher
    The aim of this study is to characterize the changes in the incidence, presentation, surgical treatment, and survival of patients with appendiceal mucinous neoplasm (AMN) over the past 4 decades using nationwide cancer surveillance data.
  47. Miura S, Suematsu Y, Matsuo Y, Tomita S, Nakayama A, Goto M, et al. The angiotensin II type 1 receptor-neprilysin inhibitor LCZ696 blocked aldosterone synthesis in a human adrenocortical cell line. Hypertens Res. 2016;39:758-763 pubmed publisher
    ..NP) or brain NP (ANP or BNP)-evoked signals that can block Ang II/AT1 receptor-induced aldosterone (Ald) synthesis in human adrenocortical cells...
  48. Wang G, Luo J, Liu J, Yang T, Xu Y, Li J, et al. pMOSFETs Featuring ALD W Filling Metal Using SiH4 and B2H6 Precursors in 22 nm Node CMOS Technology. Nanoscale Res Lett. 2017;12:306 pubmed publisher
    In this paper, pMOSFETs featuring atomic layer deposition (ALD) tungsten (W) using SiH4 and B2H6 precursors in 22 nm node CMOS technology were investigated...
  49. Li H, Liu Y, Duan Y, Yang Y, Lu Y. Method for Aluminum Oxide Thin Films Prepared through Low Temperature Atomic Layer Deposition for Encapsulating Organic Electroluminescent Devices. Materials (Basel). 2015;8:600-610 pubmed publisher
    Preparation of dense alumina (Al?O?) thin film through atomic layer deposition (ALD) provides a pathway to achieve the encapsulation of organic light emitting devices (OLED)...
  50. Yüksel S, Ziegler M, Goerke S, Huebner U, Weber K, Schaaf P, et al. Hierarchically-Designed 3D Flower-Like Composite Nanostructures as an Ultrastable, Reproducible, and Sensitive SERS Substrate. ACS Appl Mater Interfaces. 2017;9:38854-38862 pubmed publisher
    ..silica-silver composite nanostructures is induced by applying plasma-enhanced atomic layer deposition (PE-ALD) on the EGNPs...
  51. Stark M, Tan J, Tom L, Jagirdar K, Lambie D, Schaider H, et al. Whole-Exome Sequencing of Acquired Nevi Identifies Mechanisms for Development and Maintenance of Benign Neoplasms. J Invest Dermatol. 2018;138:1636-1644 pubmed publisher
    ..Finally, we propose that the balanced loss of tumor suppressor genes and oncogenes is a protective mechanism of acquired melanocytic nevi. ..
  52. Lombard Platet G, Savary S, Sarde C, Mandel J, Chimini G. A close relative of the adrenoleukodystrophy (ALD) gene codes for a peroxisomal protein with a specific expression pattern. Proc Natl Acad Sci U S A. 1996;93:1265-9 pubmed
    b>Adrenoleukodystrophy (ALD), a severe demyelinating disease, is caused by mutations in a gene coding for a peroxisomal membrane protein (ALDP), which belongs to the superfamily of ATP binding cassette (ABC) transporters and has the ..
  53. Ofman R, Dijkstra I, van Roermund C, Burger N, Turkenburg M, van Cruchten A, et al. The role of ELOVL1 in very long-chain fatty acid homeostasis and X-linked adrenoleukodystrophy. EMBO Mol Med. 2010;2:90-7 pubmed publisher
    ..X-ALD) is caused by mutations in the ABCD1 gene encoding the peroxisomal ABC transporter adrenoleukodystrophy protein (ALDP)...
  54. Miluch C, Dosdall L, Evenden M. Factors Influencing Male Plutella xylostella (Lepidoptera: Plutellidae) Capture Rates in Sex Pheromone-Baited Traps on Canola in Western Canada. J Econ Entomol. 2014;107:2067-76 pubmed publisher
    ..with lures in which Z11-16: Ac is the main component attracted significantly more moths than those in which Z11-16: Ald is the main component...
  55. Lee J, Lee D. Concentration-Dependent Mechanism Alteration of Pleurocidin Peptide in Escherichia coli. Curr Microbiol. 2016;72:159-64 pubmed publisher
    ..activity in a low concentration, we particularly focused on the induction of intracellular apoptosis-like death (ALD). Finally, it was suggested that a sub-lethal concentration of Ple led to ALD in E...
  56. Ansari R, Husain K, Rizvi S. Role of Transcription Factors in Steatohepatitis and Hypertension after Ethanol: The Epicenter of Metabolism. Biomolecules. 2016;6: pubmed publisher
    Chronic alcohol consumption induces multi-organ damage, including alcoholic liver disease (ALD), pancreatitis and hypertension. Ethanol and ethanol metabolic products play a significant role in the manifestation of its toxicity...
  57. Bluemel S, Williams B, Knight R, Schnabl B. Precision medicine in alcoholic and nonalcoholic fatty liver disease via modulating the gut microbiota. Am J Physiol Gastrointest Liver Physiol. 2016;311:G1018-G1036 pubmed publisher
    Alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) represent a major health burden in industrialized countries...
  58. Tereshchenko A, Fedorenko V, Smyntyna V, Konup I, Konup A, Eriksson M, et al. ZnO films formed by atomic layer deposition as an optical biosensor platform for the detection of Grapevine virus A-type proteins. Biosens Bioelectron. 2017;92:763-769 pubmed publisher
    ..This biosensor was based on thin films of Zinc Oxide (ZnO) deposited by atomic layer deposition (ALD)...
  59. Singh J, Yang N, Bent S. Nanoengineering Heterogeneous Catalysts by Atomic Layer Deposition. Annu Rev Chem Biomol Eng. 2017;8:41-62 pubmed publisher
    ..Atomic layer deposition (ALD) is an emerging technique that allows for synthesis of highly controlled catalysts in the form of films, ..
  60. Zhang S, Zhang B, Liang H, Liu Y, Qiao Y, Qin Y. Encapsulation of Homogeneous Catalysts in Mesoporous Materials Using Diffusion-Limited Atomic Layer Deposition. Angew Chem Int Ed Engl. 2017;: pubmed publisher
    ..materials by coating metal oxides at/near the pore entrance via diffusion-limited atomic layer deposition (ALD) to produce a "hollow plug"...
  61. Nazarov D, Zemtsova E, Valiev R, Smirnov V. Formation of Micro- and Nanostructures on the Nanotitanium Surface by Chemical Etching and Deposition of Titania Films by Atomic Layer Deposition (ALD). Materials (Basel). 2015;8:8366-8377 pubmed publisher
    ..approach included three methods: severe plastic deformation (SPD), chemical etching and atomic layer deposition (ALD)...
  62. Albet S, Bentejac M, Savary S, Gondcaille C, Netik A, Berger J, et al. Rat adrenoleukodystrophy-related (ALDR) gene: full-length cDNA sequence and new insight in expression. Biochim Biophys Acta. 2001;1517:257-69 pubmed
    X-linked adrenoleukodystrophy (X-ALD) is an inherited demyelinating disorder due to mutations in the ALD gene, which encodes a peroxisomal ABC half-transporter (ALDP)...
  63. Moser H, Moser A, Singh I, O Neill B. Adrenoleukodystrophy: survey of 303 cases: biochemistry, diagnosis, and therapy. Ann Neurol. 1984;16:628-41 pubmed
    b>Adrenoleukodystrophy (ALD) is a genetically determined disorder associated with progressive central demyelination and adrenal cortical insufficiency...
  64. Petroni A, Cappa M, Carissimi R, Blasevich M, Uziel G. Effect of testosterone metabolites on ABC half-transporter relative gene expression in X-linked adrenoleukodystrophy. J Inherit Metab Dis. 2007;30:828 pubmed
    X-linked adrenoleukodystrophy (X-ALD) is an inherited neurodegenerative disorder associated with reduced very long-chain fatty acid beta-oxidation, mainly affecting the nervous system, the adrenal cortex and the testes...
  65. Anderson N, Carroll G, Pekarek R, Christensen S, van de Lagemaat J, Neale N. Silicon Photoelectrode Thermodynamics and Hydrogen Evolution Kinetics Measured by Intensity-Modulated High-Frequency Resistivity Impedance Spectroscopy. J Phys Chem Lett. 2017;8:5253-5258 pubmed publisher
    ..indicating that SiOx is a better protective layer against oxidative electrochemical corrosion than ALD-deposited crystalline TiO2 or Al2O3...
  66. Hufendiek K, Gamulescu M, Hufendiek K, Helbig H, Märker D. Classification and characterization of acute macular neuroretinopathy with spectral domain optical coherence tomography. Int Ophthalmol. 2017;: pubmed publisher
    To classify and characterize AMN lesions with SD-OCT during a follow-up as long as 5 years. Retrospective study of 14 patients (18 eyes) with special focus on SD-OCT...
  67. Yuan P, Zheng X, Li M, Ke Y, Fu Y, Zhang Q, et al. Two Sulfur Glycoside Compounds Isolated from Lepidium apetalum Willd Protect NRK52e Cells against Hypertonic-Induced Adhesion and Inflammation by Suppressing the MAPK Signaling Pathway and RAAS. Molecules. 2017;22: pubmed publisher
    ..RAAS) system, significantly reduced the levels of angiotensin II (Ang II) and aldosterone (ALD), and lowered aquaporin-2 (AQP2) and Na?-K? ATP content in renal medulla...
  68. Hao L, Sun Q, Zhong W, Zhang W, Sun X, Zhou Z. Mitochondria-targeted ubiquinone (MitoQ) enhances acetaldehyde clearance by reversing alcohol-induced posttranslational modification of aldehyde dehydrogenase 2: A molecular mechanism of protection against alcoholic liver disease. Redox Biol. 2018;14:626-636 pubmed publisher
    ..oxygen/nitrogen species, which represents a fundamental mechanism in the pathogenesis of alcoholic liver disease (ALD)...
  69. Montagna G, Di Biase A, Cappa M, Melone M, Piantadosi C, Colabianchi D, et al. Identification of seven novel mutations in ABCD1 by a DHPLC-based assay in Italian patients with X-linked adrenoleukodystrophy. Hum Mutat. 2005;25:222 pubmed
    We report the molecular findings in 14 patients (12 families) with X-linked adrenoleukodystrophy (X-ALD, MIM# 300100), a well-defined peroxisomal disorder attributed to mutations in the ABCD1 gene on chromosome Xq28...
  70. Li Z, Roth R, Rock J, Lehman A, Marsh W, Suarez A, et al. Dual Immunostain With SATB2 and CK20 Differentiates Appendiceal Mucinous Neoplasms From Ovarian Mucinous Neoplasms. Am J Clin Pathol. 2017;147:484-491 pubmed publisher
    ..pelvic cavities may be challenging, with major differential diagnoses including appendiceal mucinous neoplasm (AMN) and ovarian mucinous neoplasm (OMN)...
  71. Hodgins N, Wang J, Al Jamal K. Nano-technology based carriers for nitrogen-containing bisphosphonates delivery as sensitisers of γδ T cells for anticancer immunotherapy. Adv Drug Deliv Rev. 2017;114:143-160 pubmed publisher
    Nitrogen containing bisphosphonates (N-BPs) including zoledronate (ZOL) and alendronate (ALD) inhibit farnesyl diphosphate synthase, and have been shown to have a cytotoxic affect against cancer cells as a monotherapy and to also ..
  72. Kim H, Arbutina K, Xu A, Liu H. Increasing the stability of DNA nanostructure templates by atomic layer deposition of Al2O3 and its application in imprinting lithography. Beilstein J Nanotechnol. 2017;8:2363-2375 pubmed publisher
    ..conformal coating with a nanometer-thin protective inorganic oxide layer created using atomic layer deposition (ALD). DNA nanotubes and origami triangles were coated with ca. 2 nm to ca. 20 nm of Al2O3...
  73. Han Z, Vehkamäki M, Salmi E, Leskelä M, Ritala M. Metal oxide multilayer hard mask system for 3D nanofabrication. Nanotechnology. 2017;: pubmed publisher
    ..Atomic layer deposition (ALD) and focused ion beam (FIB) technologies are applied for mask deposition and mask patterning, respectively...
  74. Holzinger A, Roscher A, Landgraf P, Lichtner P, Kammerer S. Genomic organization and chromosomal localization of the human peroxisomal membrane protein-1-like protein (PXMP1-L) gene encoding a peroxisomal ABC transporter. FEBS Lett. 1998;426:238-42 pubmed
    ..The best known peroxisomal member of this protein family is the adrenoleukodystrophy protein, defects of which are the underlying cause of X-linked adrenoleukodystrophy (X-ALD)...
  75. Oezen I, Rossmanith W, Forss Petter S, Kemp S, Voigtlander T, Moser Thier K, et al. Accumulation of very long-chain fatty acids does not affect mitochondrial function in adrenoleukodystrophy protein deficiency. Hum Mol Genet. 2005;14:1127-37 pubmed
    X-linked adrenoleukodystrophy (X-ALD, OMIM 300100) is a severe inherited neurodegenerative disease, associated with the accumulation of very long-chain fatty acids (VLCFA)...
  76. Gueugnon F, Volodina N, Taouil J, Lopez T, Gondcaille C, Grand A, et al. A novel cell model to study the function of the adrenoleukodystrophy-related protein. Biochem Biophys Res Commun. 2006;341:150-7 pubmed
    X-linked adrenoleukodystrophy (X-ALD) is a neurodegenerative disorder due to mutations in the ABCD1 (ALD) gene...
  77. Bavia L, de Castro Ã, Cogliati B, Dettoni J, Alves V, Isaac L. Complement C5 controls liver lipid profile, promotes liver homeostasis and inflammation in C57BL/6 genetic background. Immunobiology. 2016;221:822-32 pubmed publisher
    Innate immunity contributes effectively to the development of alcoholic liver disease (ALD). In special, the activation of the complement system is involved in the pathogenesis of this disease...
  78. Peng Y, Wang S, Li K, Liu J, Zheng Y, Shan S, et al. Identification of odorant binding proteins and chemosensory proteins in Microplitis mediator as well as functional characterization of chemosensory protein 3. PLoS ONE. 2017;12:e0180775 pubmed publisher
    ..Interestingly, three sex pheromone components of Noctuidae insects, cis-11-hexadecenyl aldehyde (Z11-16: Ald), cis-11-hexadecanol (Z11-16: OH), and trans-11-tetradecenyl acetate (E11-14: Ac), showed high binding affinities (..
  79. Ma T, Liu Z, Wang C, Zhang S, Shi X, Sun Z, et al. Production, identification, and field evaluation of sex pheromone from calling females in Diaphania angustalis (Lepidoptera: Crambidae). Environ Sci Pollut Res Int. 2017;24:24485-24493 pubmed publisher
    ..gland extracts that were subsequently evaluated showed two active compounds, (E,E)-10,12-hexadecadienal (E10E12-16:Ald) and (E,E)-10,12-hexadecadien-1-ol (E10E12-16:OH), based on comparison of retention time and mass spectrum, with ..
  80. Riva A, Patel V, Kurioka A, Jeffery H, Wright G, Tarff S, et al. Mucosa-associated invariant T cells link intestinal immunity with antibacterial immune defects in alcoholic liver disease. Gut. 2017;: pubmed publisher
    ..with systemic distribution of bacterial products are central in the immunopathogenesis of alcoholic liver disease (ALD), yet links with intestinal immunity remain elusive...
  81. Shani N, Jimenez Sanchez G, Steel G, Dean M, Valle D. Identification of a fourth half ABC transporter in the human peroxisomal membrane. Hum Mol Genet. 1997;6:1925-31 pubmed
    ..Mutations in the gene encoding ALDP cause X-linked adrenoleukodystrophy; the role of ALDR and PMP70 in human disease is unclear...
  82. Fourcade S, Savary S, Albet S, Gauthé D, Gondcaille C, Pineau T, et al. Fibrate induction of the adrenoleukodystrophy-related gene (ABCD2): promoter analysis and role of the peroxisome proliferator-activated receptor PPARalpha. Eur J Biochem. 2001;268:3490-500 pubmed
    X-linked adrenoleukodystrophy (X-ALD) is a neurodegenerative disease due to a defect in the ABCD1 (ALD) gene...
  83. Horn M, Retterstøl L, Abdelnoor M, Skjeldal O, Tallaksen C. Adrenoleukodystrophy in Norway: high rate of de novo mutations and age-dependent penetrance. Pediatr Neurol. 2013;48:212-9 pubmed publisher
    To investigate X-linked adrenoleukodystrophy in an unselected population, we performed a population based, cross-sectional prevalence study, supplemented by a retrospective study of deceased subjects...
  84. Li X, Zhang X, Yang H, Zhou Q. Atomic-layered Mn clusters deposited on palygorskite as powerful adsorbent for recovering valuable REEs from wastewater with superior regeneration stability. J Colloid Interface Sci. 2018;509:395-405 pubmed publisher
    ..Herein, we proposed a simple liquid-phase atomic layer deposition (L-ALD) method to obtain an atomic-layered MnO2 nanoparticles loaded palygorskite nanorod (MnO2@Pal),..
  85. Lee S, Yum J, Yoon S, Larsen E, Lee W, Kim S, et al. Atomic layer deposition of single-crystalline BeO epitaxially grown on GaN substrates. ACS Appl Mater Interfaces. 2017;: pubmed publisher
    We have developed a beryllium oxide (BeO) thin film process by atomic layer deposition (ALD) and grown a single-crystal BeO on a gallium nitride (GaN) substrate for the first time...
  86. Kemp S, Theodoulou F, Wanders R. Mammalian peroxisomal ABC transporters: from endogenous substrates to pathology and clinical significance. Br J Pharmacol. 2011;164:1753-66 pubmed publisher
    ..Mutations in the ABCD1 gene encoding the peroxisomal ABC transporter adrenoleukodystrophy protein are the cause for X-linked adrenoleukodystrophy, an inherited metabolic storage disorder...
  87. Chen Y, Lee Y, Tsai Y, Guo Y, Hsiao C, Tsai P, et al. Unmasking adrenoleukodystrophy in a cohort of cerebellar ataxia. PLoS ONE. 2017;12:e0177296 pubmed publisher
    b>Adrenoleukodystrophy (ALD) is a rare and progressive neurogenetic disease that may manifest disparate symptoms...
  88. Thompson K, Nazari S, Jacobs W, Grahame N, McKillop I. Use of a crossed high alcohol preferring (cHAP) mouse model with the NIAAA-model of chronic-binge ethanol intake to study liver injury. Alcohol Alcohol. 2017;52:629-637 pubmed publisher
    This study sought to compare mice bred to preferentially consume high amounts of alcohol (crossed-high alcohol preferring, cHAP) to c57BL/6 (C57) mice using a chronic-binge ethanol ingestion model to induce alcoholic liver disease (ALD).
  89. Pak Y, Park W, Mitra S, Sasikala Devi A, Loganathan K, Kumaresan Y, et al. Enhanced Performance of MoS2 Photodetectors by Inserting an ALD-Processed TiO2 Interlayer. Small. 2017;: pubmed publisher
    ..These results pave the way for practical applications and provide a novel direction for optimizing the interlayer material...
  90. Ren Q, Zhang Y, Lu H, Wang Y, Liu W, Ji X, et al. Atomic Layer Deposited of Nickel on ZnO Nanowire Arrays for High-Performance Supercapacitors. ACS Appl Mater Interfaces. 2017;: pubmed publisher
    ..indicated the NiO was formed at the interface between ZnO and Ni where the Ni was oxidized by ZnO during the ALD of Ni layer...
  91. Xiong H, Pan H, Zhang Y, Wu X. [Preliminary analysis of mutations in X-linked adrenoleukodystrophy gene(ABCD1) in Chinese patients]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2003;20:400-3 pubmed
    To detect the mutations in exon 6 of ABCD1 gene encoding adrenoleukodystrophy protein(ALDP) in Chinese X-linked adrenoleukodystrophy (ALD MIM 300100) patients.