adiponectin

Summary

Gene Symbol: adiponectin
Description: adiponectin, C1Q and collagen domain containing
Alias: ACDC, ACRP30, ADIPQTL1, ADPN, APM-1, APM1, GBP28, adiponectin, 30 kDa adipocyte complement-related protein, adipocyte complement-related 30 kDa protein, adipose most abundant gene transcript 1 protein, adipose specific collagen-like factor, gelatin-binding protein 28
Species: human
Products:     adiponectin

Top Publications

  1. Kukla M, Mazur W, Bułdak R, Zwirska Korczala K. Potential role of leptin, adiponectin and three novel adipokines--visfatin, chemerin and vaspin--in chronic hepatitis. Mol Med. 2011;17:1397-410 pubmed publisher
    ..On the other hand, it inhibits synthesis of proinflammatory mediators and enhances adiponectin production, influences adipocyte differentiation and maturation and regulates glucose uptake in adipocytes...
  2. Dastani Z, Hivert M, Timpson N, Perry J, Yuan X, Scott R, et al. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet. 2012;8:e1002607 pubmed publisher
    Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits...
  3. Poehls J, Wassel C, Harris T, Havel P, Swarbrick M, Cummings S, et al. Association of adiponectin with mortality in older adults: the Health, Aging, and Body Composition Study. Diabetologia. 2009;52:591-5 pubmed publisher
    Despite inverse associations with insulin resistance and adiposity, adiponectin has been associated with both increased and decreased risk of cardiovascular disease...
  4. Tsubakio Yamamoto K, Matsuura F, Koseki M, Oku H, Sandoval J, Inagaki M, et al. Adiponectin prevents atherosclerosis by increasing cholesterol efflux from macrophages. Biochem Biophys Res Commun. 2008;375:390-4 pubmed publisher
    ..b>Adiponectin (APN) secreted from adipocytes is one of the important molecules to inhibit the development of atherosclerosis...
  5. Pérez Martínez P, López Miranda J, Cruz Teno C, Delgado Lista J, Jiménez Gómez Y, Fernández J, et al. Adiponectin gene variants are associated with insulin sensitivity in response to dietary fat consumption in Caucasian men. J Nutr. 2008;138:1609-14 pubmed
    b>Adiponectin (adipoQ) gene variants have been associated with type 2 diabetes mellitus and insulin resistance...
  6. Margaritis M, Antonopoulos A, Digby J, Lee R, Reilly S, Coutinho P, et al. Interactions between vascular wall and perivascular adipose tissue reveal novel roles for adiponectin in the regulation of endothelial nitric oxide synthase function in human vessels. Circulation. 2013;127:2209-21 pubmed publisher
    b>Adiponectin is an adipokine with potentially important roles in human cardiovascular disease states. We studied the role of adiponectin in the cross-talk between adipose tissue and vascular redox state in patients with atherosclerosis...
  7. Windham B, Griswold M, Farasat S, Ling S, Carlson O, Egan J, et al. Influence of leptin, adiponectin, and resistin on the association between abdominal adiposity and arterial stiffness. Am J Hypertens. 2010;23:501-7 pubmed publisher
    ..adipokine production, the objectives of this study were to examine the influence of adipokines such as leptin, adiponectin, and resistin on the relationship between abdominal adiposity and arterial stiffness...
  8. Napoli N, Pedone C, Pozzilli P, Lauretani F, Ferrucci L, Incalzi R. Adiponectin and bone mass density: The InCHIANTI study. Bone. 2010;47:1001-5 pubmed publisher
    b>Adiponectin serum concentration has been reported to be inversely correlated with bone mineral density (BMD) in humans. The data on this issue, however, are biased by small study sample size and lack of controlling for body composition...
  9. Mazaki Tovi S, Romero R, Vaisbuch E, Erez O, Mittal P, Chaiworapongsa T, et al. Maternal serum adiponectin multimers in gestational diabetes. J Perinat Med. 2009;37:637-50 pubmed publisher
    b>Adiponectin, an adipokine with profound insulin-sensitizing effect, consists of heterogeneous species of multimers...

More Information

Publications312 found, 100 shown here

  1. Tian L, Luo N, Klein R, Chung B, Garvey W, Fu Y. Adiponectin reduces lipid accumulation in macrophage foam cells. Atherosclerosis. 2009;202:152-61 pubmed publisher
    b>Adiponectin is one of several, important metabolically active cytokines secreted from adipocytes...
  2. Sabouri S, Ghayour Mobarhan M, Moohebati M, Hassani M, Kassaeian J, Tatari F, et al. Association between 45T/G polymorphism of adiponectin gene and coronary artery disease in an Iranian population. ScientificWorldJournal. 2011;11:93-101 pubmed publisher
    A single nucleotide polymorphism (SNP) in the adiponectin gene, 45T/G, has been reported in relation to a number of metabolic disorders, including obesity, insulin resistance, and diabetes...
  3. Tabatabaei Malazy O, Hasani Ranjbar S, Amoli M, Heshmat R, Sajadi M, Derakhshan R, et al. Gender-specific differences in the association of adiponectin gene polymorphisms with body mass index. Rev Diabet Stud. 2010;7:241-6 pubmed publisher
    b>Adiponectin gene polymorphisms are associated with obesity, metabolic syndrome and type 2 diabetes (T2D)...
  4. Wassel C, Pankow J, Rasmussen Torvik L, Li N, Taylor K, Guo X, et al. Associations of SNPs in ADIPOQ and subclinical cardiovascular disease in the multi-ethnic study of atherosclerosis (MESA). Obesity (Silver Spring). 2011;19:840-7 pubmed publisher
    Circulating adiponectin is associated with both clinical and subclinical cardiovascular disease (CVD)...
  5. Dastani Z, Johnson T, Kronenberg F, Nelson C, Assimes T, März W, et al. The shared allelic architecture of adiponectin levels and coronary artery disease. Atherosclerosis. 2013;229:145-8 pubmed publisher
    ..Low adiponectin levels, a hormone secreted only from adipocytes, have been associated with an increased risk of CAD in ..
  6. Youn J, Kim C, Park S, Lee S, Kang S, Choi D, et al. Adiponectin and progression of arterial stiffness in hypertensive patients. Int J Cardiol. 2013;163:316-319 pubmed publisher
    ..We hypothesized that in hypertensive patients, initial levels of adipokines such as adiponectin and resistin are related to the progression of arterial stiffness, which has been proven to be associated with ..
  7. Matharoo K, Arora P, Bhanwer A. Association of adiponectin (AdipoQ) and sulphonylurea receptor (ABCC8) gene polymorphisms with Type 2 Diabetes in North Indian population of Punjab. Gene. 2013;527:228-34 pubmed publisher
    In Type 2 Diabetes (T2D), adiponectin (AdipoQ) and sulphonylurea receptor genes (ABCC8) are important targets for candidate gene association studies...
  8. Koskinen A, Juslin S, Nieminen R, Moilanen T, Vuolteenaho K, Moilanen E. Adiponectin associates with markers of cartilage degradation in osteoarthritis and induces production of proinflammatory and catabolic factors through mitogen-activated protein kinase pathways. Arthritis Res Ther. 2011;13:R184 pubmed publisher
    b>Adiponectin is an adipokine that regulates energy metabolism and insulin sensitivity, but recent studies have pointed also to a role in inflammation and arthritis...
  9. Mills K, Hamm L, Alper A, Miller C, Hudaihed A, Balamuthusamy S, et al. Circulating adipocytokines and chronic kidney disease. PLoS ONE. 2013;8:e76902 pubmed publisher
    ..We investigated the association of plasma leptin, resistin and adiponectin with CKD in 201 patients with CKD and 201 controls without...
  10. Vetvik K, Sonerud T, Lindeberg M, Lüders T, Størkson R, Jonsdottir K, et al. Globular adiponectin and its downstream target genes are up-regulated locally in human colorectal tumors: ex vivo and in vitro studies. Metabolism. 2014;63:672-81 pubmed publisher
    Low plasma adiponectin levels are linked to obesity, insulin resistance, and the risk of several types of malignancy...
  11. Donoso M, Muñoz Calvo M, Barrios V, Martinez G, Hawkins F, Argente J. Increased leptin/adiponectin ratio and free leptin index are markers of insulin resistance in obese girls during pubertal development. Horm Res Paediatr. 2013;80:363-70 pubmed publisher
    ..We hypothesized that the leptin/adiponectin (L/A) ratio and free leptin index (FLI) are good markers of insulin resistance (IR) and total body fat (TBF) ..
  12. Sulistyoningrum D, Gasevic D, Lear S, Ho J, Mente A, Devlin A. Total and high molecular weight adiponectin and ethnic-specific differences in adiposity and insulin resistance: a cross-sectional study. Cardiovasc Diabetol. 2013;12:170 pubmed publisher
    ..b>Adiponectin is an insulin sensitizing adipocytokine that circulates as multiple isoforms, with high molecular weight (HMW) ..
  13. Ye E, Yang H, Chen L, Chen Q, Sun M, Lin Z, et al. Adiponectin and peroxisome proliferator-activated receptor-? gene polymorphisms and gene-gene interactions with type 2 diabetes. Life Sci. 2014;98:55-9 pubmed publisher
    To investigate whether gene polymorphisms of both adiponectin and peroxisome proliferator-activated receptor gamma (PPAR?) influence type 2 diabetes mellitus (T2DM) respectively in the Han people of the Wenzhou region of China and ..
  14. Ahasic A, Zhao Y, Su L, Sheu C, Thompson B, Christiani D. Adiponectin gene polymorphisms and acute respiratory distress syndrome susceptibility and mortality. PLoS ONE. 2014;9:e89170 pubmed publisher
    b>Adiponectin is an anti-inflammatory adipokine that is the most abundant gene product of adipose tissue. Lower levels have been observed in obesity, insulin resistance, and in critical illness...
  15. Choi H, Lee Y, Lee S, Hong S, Hahm D, Choi S, et al. Adiponectin may contribute to synovitis and joint destruction in rheumatoid arthritis by stimulating vascular endothelial growth factor, matrix metalloproteinase-1, and matrix metalloproteinase-13 expression in fibroblast-like synoviocytes more than . Arthritis Res Ther. 2009;11:R161 pubmed publisher
    The role of adiponectin in the pathogenesis of arthritis is still controversial...
  16. Persson J, Lindberg K, Gustafsson T, Eriksson P, Paulsson Berne G, Lundman P. Low plasma adiponectin concentration is associated with myocardial infarction in young individuals. J Intern Med. 2010;268:194-205 pubmed publisher
    The importance of adiponectin in coronary heart disease remains to be elucidated...
  17. Ding C, Li L, Su Y, Xiang R, Cong X, Yu H, et al. Adiponectin increases secretion of rat submandibular gland via adiponectin receptors-mediated AMPK signaling. PLoS ONE. 2013;8:e63878 pubmed publisher
    b>Adiponectin and adiponectin receptors (AdipoR1/2) are expressed in various tissues and are involved in the regulation of multiple functions such as energy metabolism and inflammatory responses...
  18. Schaffler A, Langmann T, Palitzsch K, Scholmerich J, Schmitz G. Identification and characterization of the human adipocyte apM-1 promoter. Biochim Biophys Acta. 1998;1399:187-97 pubmed
    ..In addition, an exon/intron boundary was mapped at the extreme 5'-end of the cDNA sequence. Genomic Southern blotting suggests that the human apM-1 gene is a single copy gene. ..
  19. Ling H, Waterworth D, Stirnadel H, Pollin T, Barter P, Kesaniemi Y, et al. Genome-wide linkage and association analyses to identify genes influencing adiponectin levels: the GEMS Study. Obesity (Silver Spring). 2009;17:737-44 pubmed publisher
    b>Adiponectin has a variety of metabolic effects on obesity, insulin sensitivity, and atherosclerosis...
  20. Une K, Takei Y, Tomita N, Asamura T, Ohrui T, Furukawa K, et al. Adiponectin in plasma and cerebrospinal fluid in MCI and Alzheimer's disease. Eur J Neurol. 2011;18:1006-9 pubmed publisher
    ..We here analysed adiponectin, one of the most important adipocytokines, in plasma and cerebrospinal fluid (CSF) from cognitive normal ..
  21. Diez J, Iglesias P. The role of the novel adipocyte-derived hormone adiponectin in human disease. Eur J Endocrinol. 2003;148:293-300 pubmed
    b>Adiponectin, also called GBP-28, apM1, AdipoQ and Acrp30, is a novel adipose tIssue-specific protein that has structural homology to collagen VIII and X and complement factor C1q, and that circulates in human plasma at high levels...
  22. Chang Y, Jiang J, Jiang Y, Chiang F, Hwang J, Lien W, et al. Interaction of ADIPOQ genetic polymorphism with blood pressure and plasma cholesterol level on the risk of coronary artery disease. Circ J. 2009;73:1934-8 pubmed
    The protective effect of +45T >G polymorphism in the adiponectin gene (ADIPOQ) on coronary artery disease (CAD) has been demonstrated in European populations, so this study investigated the effect of +45T >G polymorphism on the ..
  23. Al Daghri N, Al Attas O, Alokail M, Alkharfy K, Hussain T. Adiponectin gene variants and the risk of coronary artery disease in patients with type 2 diabetes. Mol Biol Rep. 2011;38:3703-8 pubmed publisher
    ..Several studies have indicated a role of adiponectin gene in the increased coronary artery disease (CAD) risk in T2D patients...
  24. Yang W, Lee W, Funahashi T, Tanaka S, Matsuzawa Y, Chao C, et al. Plasma adiponectin levels in overweight and obese Asians. Obes Res. 2002;10:1104-10 pubmed
    ..in subjects with obesity, diabetes mellitus, or coronary heart disease, suggesting a potential use of plasma adiponectin in following the clinical progress in subjects with metabolic syndrome (MS)...
  25. Guebre Egziabher F, Bernhard J, Funahashi T, Hadj Aissa A, Fouque D. Adiponectin in chronic kidney disease is related more to metabolic disturbances than to decline in renal function. Nephrol Dial Transplant. 2005;20:129-34 pubmed
    b>Adiponectin, a newly discovered collagen-like protein of the collectin family exclusively produced by adipocytes, possesses anti-inflammatory properties...
  26. Störk S, Bots M, Angerer P, von Schacky C, Grobbee D, Angermann C, et al. Low levels of adiponectin predict worsening of arterial morphology and function. Atherosclerosis. 2007;194:e147-53 pubmed
    ..In 142 non-diabetic postmenopausal women, we investigated whether plasma levels of adiponectin and leptin are associated with changes in carotid intima-media thickness (IMT) and distensibility as assessed ..
  27. Miyatani Y, Yasui T, Uemura H, Yamada M, Matsuzaki T, Kuwahara A, et al. Associations of circulating adiponectin with estradiol and monocyte chemotactic protein-1 in postmenopausal women. Menopause. 2008;15:536-41 pubmed publisher
    The aim of the present study was to clarify the association of serum adiponectin concentrations with serum 17beta-estradiol concentrations in pre-, peri-, and postmenopausal women...
  28. Tietge U, Böker K, Manns M, Bahr M. Elevated circulating adiponectin levels in liver cirrhosis are associated with reduced liver function and altered hepatic hemodynamics. Am J Physiol Endocrinol Metab. 2004;287:E82-9 pubmed
    b>Adiponectin is a novel adipocytokine negatively correlated with parameters of the metabolic syndrome, such as body mass index (BMI), body fat mass (BFM), and circulating insulin levels...
  29. Mantzoros C, Petridou E, Alexe D, Skalkidou A, Dessypris N, Papathoma E, et al. Serum adiponectin concentrations in relation to maternal and perinatal characteristics in newborns. Eur J Endocrinol. 2004;151:741-6 pubmed
    To assess serum adiponectin levels of neonates in relation to ponderal index and birth length with and without adjustment for potential confounding factors including maternal factors and perinatal characteristics. A cross-sectional study...
  30. Miller M, Cho J, Pham A, Ramsdell J, Broide D. Adiponectin and functional adiponectin receptor 1 are expressed by airway epithelial cells in chronic obstructive pulmonary disease. J Immunol. 2009;182:684-91 pubmed
    ..pulmonary disease-Emphysema) and control subjects using a 120 Ab cytokine array and demonstrated that adiponectin was highly expressed in BAL in COPD-E...
  31. Prior S, Gable D, Cooper J, Bain S, Hurel S, Humphries S, et al. Association between the adiponectin promoter rs266729 gene variant and oxidative stress in patients with diabetes mellitus. Eur Heart J. 2009;30:1263-9 pubmed publisher
    Low levels of adiponectin are associated with type 2 diabetes and coronary heart disease (CHD). Recent evidence also suggests that low levels of adiponectin are associated with increased oxidative stress...
  32. Keku T, Vidal A, Oliver S, Hoyo C, Hall I, Omofoye O, et al. Genetic variants in IGF-I, IGF-II, IGFBP-3, and adiponectin genes and colon cancer risk in African Americans and Whites. Cancer Causes Control. 2012;23:1127-38 pubmed publisher
    ..growth factor-2 (IGF-II) (rs680), insulin-like growth factor-binding protein-3 (IGFBP-3) (rs2854744), and adiponectin (APM1 rs1501299) with colon cancer risk, as well as relationships with circulating IGF-I, IGF-II, IGFBP-3, and ..
  33. Mitsuhashi H, Yatsuya H, Tamakoshi K, Matsushita K, Otsuka R, Wada K, et al. Adiponectin level and left ventricular hypertrophy in Japanese men. Hypertension. 2007;49:1448-54 pubmed
    A recent study has demonstrated that adiponectin inhibited hypertrophic signaling in the myocardium of mice, implying that a decrease in the blood adiponectin level could cause cardiac muscle hypertrophy...
  34. Warodomwichit D, Shen J, Arnett D, Tsai M, Kabagambe E, Peacock J, et al. ADIPOQ polymorphisms, monounsaturated fatty acids, and obesity risk: the GOLDN study. Obesity (Silver Spring). 2009;17:510-7 pubmed publisher
    Serum adiponectin levels have been positively associated with insulin sensitivity and are decreased in type 2 diabetes (T2D) and obesity...
  35. Zhang H, Mo X, Hao Y, Gu D. Association between polymorphisms in the adiponectin gene and cardiovascular disease: a meta-analysis. BMC Med Genet. 2012;13:40 pubmed publisher
    Previous studies have examined the associations between polymorphisms of adiponectin gene (ADIPOQ) and cardiovascular disease (CVD), but those studies have been inconclusive...
  36. Hascoët S, Elbaz M, Bongard V, Bouisset F, Verdier C, Vindis C, et al. Adiponectin and long-term mortality in coronary artery disease participants and controls. Arterioscler Thromb Vasc Biol. 2013;33:e19-29 pubmed publisher
    Despite cardioprotective properties, studies investigating adiponectin as a cardiovascular disease marker led to conflicting results...
  37. Barth N, Langmann T, Scholmerich J, Schmitz G, Schaffler A. Identification of regulatory elements in the human adipose most abundant gene transcript-1 ( apM-1) promoter: role of SP1/SP3 and TNF-alpha as regulatory pathways. Diabetologia. 2002;45:1425-33 pubmed
  38. Pollin T, Tanner K, O Connell J, Ott S, Damcott C, Shuldiner A, et al. Linkage of plasma adiponectin levels to 3q27 explained by association with variation in the APM1 gene. Diabetes. 2005;54:268-74 pubmed
    We performed a genome-wide linkage scan of plasma adiponectin levels in 569 nondiabetic participants in the Amish Family Diabetes Study. The highest logarithm of odds (LOD) score (2.13; P = 0...
  39. González Sánchez J, Zabena C, Martinez Larrad M, Fernandez Perez C, Pérez Barba M, Laakso M, et al. An SNP in the adiponectin gene is associated with decreased serum adiponectin levels and risk for impaired glucose tolerance. Obes Res. 2005;13:807-12 pubmed
    b>Adiponectin is a plasma protein produced by the adipose tissue. Hypoadiponectinemia has been associated with insulin resistance and several components of the metabolic syndrome (MS): type 2 diabetes, obesity, and dyslipidemia...
  40. Semple R, Halberg N, Burling K, Soos M, Schraw T, Luan J, et al. Paradoxical elevation of high-molecular weight adiponectin in acquired extreme insulin resistance due to insulin receptor antibodies. Diabetes. 2007;56:1712-7 pubmed
    Total plasma adiponectin and high-molecular weight (HMW) polymeric adiponectin are strongly positively correlated with insulin sensitivity...
  41. Wang Y, Zhang D, Liu Y, Yang Y, Zhao T, Xu J, et al. Association study of the single nucleotide polymorphisms in adiponectin-associated genes with type 2 diabetes in Han Chinese. J Genet Genomics. 2009;36:417-23 pubmed publisher
    ..To investigate the contribution of the adiponectin genes and their receptors to T2DM, a case-control study was performed and 11 SNPs of ADIPOQ, ADIPOR1, and ..
  42. Asferg C, Møgelvang R, Flyvbjerg A, Frystyk J, Jensen J, Marott J, et al. Leptin, not adiponectin, predicts hypertension in the Copenhagen City Heart Study. Am J Hypertens. 2010;23:327-33 pubmed publisher
    Leptin and adiponectin are hormones secreted by adipose tissue, and both hormones are candidate intermediaries between adipose tissue and overweight-related diseases...
  43. Low C, Mohd Tohit E, Chong P, Idris F. Adiponectin SNP45TG is associated with gestational diabetes mellitus. Arch Gynecol Obstet. 2011;283:1255-60 pubmed publisher
    ..Accumulating literature had suggested that adiponectin plays a role in the pathophysiology of this metabolic syndrome, and several of the common single nucleotide ..
  44. Moghadasi M, Mohebbi H, Rahmani Nia F, Hassan Nia S, Noroozi H, Pirooznia N. High-intensity endurance training improves adiponectin mRNA and plasma concentrations. Eur J Appl Physiol. 2012;112:1207-14 pubmed publisher
    b>Adiponectin is an anti-inflammatory protein that reduced in obesity...
  45. Eglit T, Lember M, Ringmets I, Rajasalu T. Gender differences in serum high-molecular-weight adiponectin levels in metabolic syndrome. Eur J Endocrinol. 2013;168:385-91 pubmed publisher
    ..was to estimate gender-specific associations between metabolic syndrome (MS) and high-molecular-weight (HMW) adiponectin in an Estonian adult population...
  46. Lacquemant C, Froguel P, Lobbens S, Izzo P, Dina C, Ruiz J. The adiponectin gene SNP+45 is associated with coronary artery disease in Type 2 (non-insulin-dependent) diabetes mellitus. Diabet Med. 2004;21:776-81 pubmed
    The ACRP30/adiponectin gene on chromosome 3q27, a region linked to the metabolic syndrome, encodes for the abundant adipocyte-specific secreted protein...
  47. Matsumoto M, Ishikawa S, Kajii E. Association of adiponectin with cerebrovascular disease: a nested case-control study. Stroke. 2008;39:323-8 pubmed
    Even though adiponectin is associated with many traditional cardiovascular risk factors, studies assessing the association between adiponectin and cerebrovascular disease (CVD) are scarce...
  48. Moore S, Leitzmann M, Albanes D, Weinstein S, Snyder K, Virtamo J, et al. Adipokine genes and prostate cancer risk. Int J Cancer. 2009;124:869-76 pubmed publisher
    ..05). Polymorphisms in the IL6, LEPR, TNF and ADIPOQ genes were not associated with prostate cancer. Allelic variants in the LEP gene are related to prostate cancer risk, supporting a role for leptin in prostate carcinogenesis. ..
  49. Boumaiza I, Omezzine A, Rejeb J, Rebhi L, Ben Rejeb N, Nabli N, et al. Single-nucleotide polymorphisms at the adiponectin locus and risk of coronary artery disease in Tunisian coronaries. J Cardiovasc Med (Hagerstown). 2011;12:619-24 pubmed publisher
    b>Adiponectin is an adipocyte-derived hormone and an essential modulator of insulin sensitivity...
  50. Katakami N, Kaneto H, Matsuoka T, Takahara M, Maeda N, Shimizu I, et al. Adiponectin G276T gene polymorphism is associated with cardiovascular disease in Japanese patients with type 2 diabetes. Atherosclerosis. 2012;220:437-42 pubmed publisher
    b>Adiponectin has anti-atherogenic properties and reduced serum adiponectin levels are associated with cardiovascular disease (CVD)...
  51. Faraj M, Havel P, Phélis S, Blank D, Sniderman A, Cianflone K. Plasma acylation-stimulating protein, adiponectin, leptin, and ghrelin before and after weight loss induced by gastric bypass surgery in morbidly obese subjects. J Clin Endocrinol Metab. 2003;88:1594-602 pubmed
    We examined fasting plasma insulin, acylation-stimulating protein (ASP), leptin, adiponectin, ghrelin, and metabolic/cardiovascular risk profile before and 15 +/- 6 months after isolated Roux-en-Y gastric bypass surgery in 50 morbidly ..
  52. Wannamethee S, Tchernova J, Whincup P, Lowe G, Rumley A, Brown K, et al. Associations of adiponectin with metabolic and vascular risk parameters in the British Regional Heart Study reveal stronger links to insulin resistance-related than to coronory heart disease risk-related parameters. Int J Obes (Lond). 2007;31:1089-98 pubmed
    b>Adiponectin is considered by many to be part of the 'common soil' linking type 2 diabetes and coronary heart disease (CHD)...
  53. Vendramini M, Pereira A, Ferreira S, Kasamatsu T, Moises R. Association of genetic variants in the adiponectin encoding gene (ADIPOQ) with type 2 diabetes in Japanese Brazilians. J Diabetes Complications. 2010;24:115-20 pubmed publisher
    ..3% against 3.1% in NGT individuals, P=.0003). Also, this haplotype was associated with decreased levels of adiponectin. We also identified three mutations in exon 3: I164T, R221S, and H241P, but, owing to the low frequencies of ..
  54. Foucan L, Ezourhi N, Maimaitiming S, Hedreville S, Inamo J, Atallah A, et al. Adiponectin multimers and ADIPOQ T45G in coronary artery disease in Caribbean type 2 diabetic subjects of African descent. Obesity (Silver Spring). 2010;18:1466-8 pubmed publisher
    Ethnic differences may affect the association of adiponectin (Ad) multimers with coronary artery disease (CAD). We analyzed the associations of total Ad, Ad multimers, and T45G polymorphism of ADIPOQ gene with pre-existing CAD...
  55. Gulcelik N, Halil M, Ariogul S, Usman A. Adipocytokines and aging: adiponectin and leptin. Minerva Endocrinol. 2013;38:203-10 pubmed
    ..b>Adiponectin is an insulin sensitizing, anti-inflammatory, and antiathoregenic adipokine...
  56. Takemura Y, Walsh K, Ouchi N. Adiponectin and cardiovascular inflammatory responses. Curr Atheroscler Rep. 2007;9:238-43 pubmed
    ..Although most adipokines induce inflammation, adiponectin inhibits inflammatory reactions and protects against metabolic and cardiovascular diseases...
  57. Metcalf B, Jeffery A, Hosking J, Voss L, Sattar N, Wilkin T. Objectively measured physical activity and its association with adiponectin and other novel metabolic markers: a longitudinal study in children (EarlyBird 38). Diabetes Care. 2009;32:468-73 pubmed publisher
    ..The metabolic markers at 8 years were adiponectin, leptin, high-sensitivity C-reactive protein (hsCRP), and insulin resistance (homeostasis model assessment)...
  58. Wang B, Wang C, Wei D, Zhang J, He H, Ma M, et al. An association study of SNP + 45 T > G of the AdipoQ gene with type 2 diabetes in Yi and Han people in China. Int J Vitam Nutr Res. 2011;81:392-7 pubmed publisher
    ..1 (95 % CI: 0.8, 1.6) in Yi people and OR of 1.0 (95 % CI: 0.7, 1.4) in Han people. The SNP + 45 (rs2241766) of the AdipoQ gene is not associated with T2D neither in Yi nor in Han people in southwestern China. ..
  59. Drolet R, Bélanger C, Fortier M, Huot C, Mailloux J, Légaré D, et al. Fat depot-specific impact of visceral obesity on adipocyte adiponectin release in women. Obesity (Silver Spring). 2009;17:424-30 pubmed publisher
    Our objective was to examine omental and subcutaneous adipocyte adiponectin release in women...
  60. Kaklamani V, Yi N, Zhang K, Sadim M, Offit K, Oddoux C, et al. Polymorphisms of ADIPOQ and ADIPOR1 and prostate cancer risk. Metabolism. 2011;60:1234-43 pubmed publisher
    Studies have linked prostate cancer risk with insulin resistance and obesity. Circulating levels of adiponectin, a protein involved in insulin resistance and obesity, have been associated with prostate cancer risk...
  61. Qi L, Menzaghi C, Salvemini L, De Bonis C, Trischitta V, Hu F. Novel locus FER is associated with serum HMW adiponectin levels. Diabetes. 2011;60:2197-201 pubmed publisher
    High molecular weight (HMW) adiponectin is a predominant isoform of circulating adiponectin and has been related to type 2 diabetes...
  62. Miyazaki T, Bub J, Uzuki M, Iwamoto Y. Adiponectin activates c-Jun NH2-terminal kinase and inhibits signal transducer and activator of transcription 3. Biochem Biophys Res Commun. 2005;333:79-87 pubmed
    b>Adiponectin, a major adipose cytokine, plays a crucial role in the inhibition of metabolic syndrome by acting on such cell types as muscle cells and hepatocytes...
  63. Mahadev K, Wu X, Donnelly S, Ouedraogo R, Eckhart A, Goldstein B. Adiponectin inhibits vascular endothelial growth factor-induced migration of human coronary artery endothelial cells. Cardiovasc Res. 2008;78:376-84 pubmed publisher
    ..cell migration and angiogenesis are associated with the vascular complications of diabetes mellitus, and adiponectin is an abundant plasma adipokine that exhibits salutary effects on endothelial function...
  64. Nakano Y, Tobe T, Choi Miura N, Mazda T, Tomita M. Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma. J Biochem. 1996;120:803-12 pubmed
    By use of its affinity to gelatin-Cellulofine, a novel protein, GBP28 (gelatin-binding protein of 28 kDa), was obtained from human plasma. GBP28 bound to gelatin-Cellulofine could be eluted with 1 M NaCl...
  65. Vasseur F, Helbecque N, Dina C, Lobbens S, Delannoy V, Gaget S, et al. Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians. Hum Mol Genet. 2002;11:2607-14 pubmed
    b>Adiponectin (ACRP30), an adipocyte-secreted protein encoded by the APM1 gene, is known to modulate insulin sensitivity and glucose homeostasis, those effects protecting obese mice from diabetes...
  66. Martin M, Palaniappan L, Kwan A, Reaven G, Reaven P. Ethnic differences in the relationship between adiponectin and insulin sensitivity in South Asian and Caucasian women. Diabetes Care. 2008;31:798-801 pubmed publisher
    To assess whether lower adiponectin concentrations in South Asian Indians may be responsible for their greater degree of insulin resistance...
  67. Olszanecka Glinianowicz M, Kuglin D, Dąbkowska Huć A, Skałba P. Serum adiponectin and resistin in relation to insulin resistance and markers of hyperandrogenism in lean and obese women with polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol. 2011;154:51-6 pubmed publisher
    ..The aim of the study was to assess the relationship between plasma adiponectin and resistin levels and insulin resistance and markers of hyperandrogenism in lean and obese PCOS women...
  68. Dalamaga M, Diakopoulos K, Mantzoros C. The role of adiponectin in cancer: a review of current evidence. Endocr Rev. 2012;33:547-94 pubmed publisher
    ..b>Adiponectin, the most abundant protein secreted by adipose tissue, exhibits insulin-sensitizing, antiinflammatory, ..
  69. Kita A, Yamasaki H, Kuwahara H, Moriuchi A, Fukushima K, Kobayashi M, et al. Identification of the promoter region required for human adiponectin gene transcription: Association with CCAAT/enhancer binding protein-beta and tumor necrosis factor-alpha. Biochem Biophys Res Commun. 2005;331:484-90 pubmed
    b>Adiponectin, an adipose tissue-specific plasma protein, is involved in insulin sensitizing and has anti-atherosclerotic properties...
  70. Ehling A, Schaffler A, Herfarth H, Tarner I, Anders S, Distler O, et al. The potential of adiponectin in driving arthritis. J Immunol. 2006;176:4468-78 pubmed
    ..between adipose tissue, adipocytokines, and arthritis, we investigated the expression of the adipocytokine adiponectin and its functional role in articular adipose tissue and synovium of patients with different arthritides...
  71. Ramya K, Ayyappa K, Ghosh S, Mohan V, Radha V. Genetic association of ADIPOQ gene variants with type 2 diabetes, obesity and serum adiponectin levels in south Indian population. Gene. 2013;532:253-62 pubmed publisher
    To investigate the genetic association of eight variants of the adiponectin gene with type 2 diabetes mellitus (T2DM), obesity and serum adiponectin level in the south Indian population...
  72. Lau C, Muniandy S. Adiponectin and resistin gene polymorphisms in association with their respective adipokine levels. Ann Hum Genet. 2011;75:370-82 pubmed publisher
    Single nucleotide polymorphisms (SNPs) at the adiponectin and resistin loci are strongly associated with hypoadiponectinemia and hyperresistinemia, which may eventually increase risk of insulin resistance, type 2 diabetes (T2DM), ..
  73. Cui E, Deng A, Wang X, Wang B, Mao W, Feng X, et al. The role of adiponectin (ADIPOQ) gene polymorphisms in the susceptibility and prognosis of non-small cell lung cancer. Biochem Cell Biol. 2011;89:308-13 pubmed publisher
    To study the role of the adiponectin (ADIPOQ) gene single-nucleotide polymorphism (SNP) in the susceptibility and prognosis for non-small cell lung cancer (NSCLC), we recruited 344 patients with NSCLC, of which 141 had undergone surgical ..
  74. Matsuzawa Y, Funahashi T, Kihara S, Shimomura I. Adiponectin and metabolic syndrome. Arterioscler Thromb Vasc Biol. 2004;24:29-33 pubmed
    ..sequence analysis of expressed genes in adipocytes, we identified an adipose-specific collagen-like molecule, adiponectin. This novel adipocytokine has plural biofunctions, such as antidiabetic, antiatherosclerotic, and ..
  75. Truyen I, De Grijse J, Van Schravendijk C, De Smet D, Decochez K, Vandemeulebroucke E, et al. Adiponectin levels do not predict clinical onset of type 1 diabetes in antibody-positive relatives. Diabetologia. 2007;50:2143-6 pubmed
    Insulin resistance has been proposed as a risk factor for type 1 diabetes. We investigated whether adiponectin, an insulin sensitiser, can serve as an additional predictive marker for type 1 diabetes in first-degree relatives of known ..
  76. Chen T, Chen L, Hsieh M, Chang C, Chou D, Tsai S. Evidence for a protective role for adiponectin in osteoarthritis. Biochim Biophys Acta. 2006;1762:711-8 pubmed
    ..However, the mechanism by which obesity contributes to OA remains uncertain. Adiponectin, an adipocyte-derived hormone, has shown anti-diabetic and anti-atherogenic properties...
  77. Ouchi N, Kihara S, Arita Y, Okamoto Y, Maeda K, Kuriyama H, et al. Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway. Circulation. 2000;102:1296-301 pubmed
    Among the many adipocyte-derived endocrine factors, we found an adipocyte-derived plasma protein, adiponectin, that was decreased in obesity...
  78. Filippi E, Sentinelli F, Romeo S, Arca M, Berni A, Tiberti C, et al. The adiponectin gene SNP+276G>T associates with early-onset coronary artery disease and with lower levels of adiponectin in younger coronary artery disease patients (age <or=50 years). J Mol Med (Berl). 2005;83:711-9 pubmed
    b>Adiponectin, an adipocyte-derived protein, is an essential modulator of insulin sensitivity and several studies suggest an important role of adiponectin in the processes leading to atherosclerosis, thus indicating the adiponectin gene as ..
  79. Dalamaga M, Migdalis I, Fargnoli J, Papadavid E, Bloom E, Mitsiades N, et al. Pancreatic cancer expresses adiponectin receptors and is associated with hypoleptinemia and hyperadiponectinemia: a case-control study. Cancer Causes Control. 2009;20:625-33 pubmed publisher
    Obesity and insulin resistance have been implicated in the etiology of pancreatic cancer (PC). Whether adiponectin and/or leptin, two adipocyte-secreted hormones important in metabolic regulation, are associated with PC pathogenesis and ..
  80. Cohen S, Gammon M, North K, Millikan R, Lange E, Williams S, et al. ADIPOQ, ADIPOR1, and ADIPOR2 polymorphisms in relation to serum adiponectin levels and BMI in black and white women. Obesity (Silver Spring). 2011;19:2053-62 pubmed publisher
    b>Adiponectin is an adipose-secreted protein with influence on several physiologic pathways including those related to insulin sensitivity, inflammation, and atherogenesis...
  81. Lorente Cebrián S, Eriksson A, Dunlop T, Mejhert N, Dahlman I, Aström G, et al. Differential effects of 1?,25-dihydroxycholecalciferol on MCP-1 and adiponectin production in human white adipocytes. Eur J Nutr. 2012;51:335-42 pubmed publisher
    ..two key factors with pro-inflammatory [monocyte chemoattractant protein-1 (MCP-1/CCL2)] and anti-inflammatory [adiponectin (ADIPOQ)] effects...
  82. Mohlig M, Wegewitz U, Osterhoff M, Isken F, Ristow M, Pfeiffer A, et al. Insulin decreases human adiponectin plasma levels. Horm Metab Res. 2002;34:655-8 pubmed
    Insulin resistance and hyperinsulinemia are known atherosclerosis risk factors. The association between adiponectin plasma levels and obesity, insulinemia, and atherosclerosis has been shown...
  83. Kajantie E, Hytinantti T, Hovi P, Andersson S. Cord plasma adiponectin: a 20-fold rise between 24 weeks gestation and term. J Clin Endocrinol Metab. 2004;89:4031-6 pubmed
    b>Adiponectin is an adipocyte-derived hormone with profound insulin-sensitizing, antiinflammatory, and antiatherogenic effects...
  84. Qi L, Li T, Rimm E, Zhang C, Rifai N, Hunter D, et al. The +276 polymorphism of the APM1 gene, plasma adiponectin concentration, and cardiovascular risk in diabetic men. Diabetes. 2005;54:1607-10 pubmed
    Recently, the genetic variability at adiponectin locus (APM1) was associated with cardiovascular risk in patients with type 2 diabetes...
  85. Broedl U, Lebherz C, Lehrke M, Stark R, Greif M, Becker A, et al. Low adiponectin levels are an independent predictor of mixed and non-calcified coronary atherosclerotic plaques. PLoS ONE. 2009;4:e4733 pubmed publisher
    ..Low serum adiponectin levels were reported to be associated with coronary artery disease and future incidence of acute coronary ..
  86. Wang J, Lee C, Lee C, Chen Y, Lee R, Hsu B. Fasting adiponectin is inversely correlated with metabolic syndrome in patients with coronary artery disease. Intern Med. 2010;49:739-47 pubmed
    ..or extent of coronary artery disease (CAD), the relationship between metabolic syndrome and fasting serum adiponectin concentration in CAD patients are not well elucidated. Fasting blood samples were obtained from 98 CAD patients...
  87. Ryo M, Nakamura T, Kihara S, Kumada M, Shibazaki S, Takahashi M, et al. Adiponectin as a biomarker of the metabolic syndrome. Circ J. 2004;68:975-81 pubmed
    ..b>Adiponectin is an adipose-derived plasma protein with anti-atherogenic and insulin-sensitizing activities...