ACVR2A

Summary

Gene Symbol: ACVR2A
Description: activin A receptor type 2A
Alias: ACTRII, ACVR2, activin receptor type-2A, activin A receptor, type IIA
Species: human
Products:     ACVR2A

Top Publications

  1. Schneider Kolsky M, Manuelpillai U, Waldron K, Dole A, Wallace E. The distribution of activin and activin receptors in gestational tissues across human pregnancy and during labour. Placenta. 2002;23:294-302 pubmed
    ..There were no differences with labour onset. ..
  2. Jung B, Doctolero R, Tajima A, Nguyen A, Keku T, Sandler R, et al. Loss of activin receptor type 2 protein expression in microsatellite unstable colon cancers. Gastroenterology. 2004;126:654-9 pubmed
    ..The activin type 2 receptor (ACVR2), possessing 2 polyadenine coding sequences, was identified as a mutational target, but it is not clear if ..
  3. Jung B, Smith E, Doctolero R, Gervaz P, Alonso J, Miyai K, et al. Influence of target gene mutations on survival, stage and histology in sporadic microsatellite unstable colon cancers. Int J Cancer. 2006;118:2509-13 pubmed
    ..TGFBR2 and ACVR2, encoding TGFbeta superfamily receptors, and the proapoptotic gene BAX are frequent targets for frameshift ..
  4. Olaru A, Mori Y, Yin J, Wang S, Kimos M, Perry K, et al. Loss of heterozygosity and mutational analyses of the ACTRII gene locus in human colorectal tumors. Lab Invest. 2003;83:1867-71 pubmed
    The activin type II receptorgene (ACTRII) is mutated in 58...
  5. Roten L, Johnson M, Forsmo S, Fitzpatrick E, Dyer T, Brennecke S, et al. Association between the candidate susceptibility gene ACVR2A on chromosome 2q22 and pre-eclampsia in a large Norwegian population-based study (the HUNT study). Eur J Hum Genet. 2009;17:250-7 pubmed publisher
    ..rs1014064, rs17742134, rs1424941, rs2161983, rs3768687 and rs3764955) within the activin receptor type 2 gene (ACVR2A) (all P-values <0.05)...
  6. Chung H, Young D, Lopez C, Le T, Lee J, Ream Robinson D, et al. Mutation rates of TGFBR2 and ACVR2 coding microsatellites in human cells with defective DNA mismatch repair. PLoS ONE. 2008;3:e3463 pubmed publisher
    ..through generating frameshift mutations at coding microsatellites of tumor suppressor genes, such as TGFBR2 and ACVR2. As a consequence, signaling through these TGFbeta family receptors is abrogated in DNA Mismatch repair (MMR)-..
  7. Fitzpatrick E, Johnson M, Dyer T, Forrest S, Elliott K, Blangero J, et al. Genetic association of the activin A receptor gene (ACVR2A) and pre-eclampsia. Mol Hum Reprod. 2009;15:195-204 pubmed publisher
    ..2q22 in 34 Australian/New Zealand (Aust/NZ) pre-eclampsia/eclampsia families, and activin A receptor type IIA (ACVR2A) was identified as a strong positional candidate gene at this locus...
  8. Jung B, Beck S, Cabral J, Chau E, Cabrera B, Fiorino A, et al. Activin type 2 receptor restoration in MSI-H colon cancer suppresses growth and enhances migration with activin. Gastroenterology. 2007;132:633-44 pubmed
    ..b>ACVR2 is mutated at its exon 10 polyadenine tract in >80% of MSI-H colon cancers, coinciding with loss of protein...
  9. Xu J, McKeehan K, Matsuzaki K, McKeehan W. Inhibin antagonizes inhibition of liver cell growth by activin by a dominant-negative mechanism. J Biol Chem. 1995;270:6308-13 pubmed
    ..Here we show that beta:beta activin binds to the activin type II receptor kinase (ActRII) which induces activin binding to the type I receptor kinase SKR2 to form ActRII.beta:beta...

More Information

Publications124 found, 100 shown here

  1. Chang H, Fang L, Cheng J, Klausen C, Sun Y, Leung P. Growth differentiation factor 8 down-regulates pentraxin 3 in human granulosa cells. Mol Cell Endocrinol. 2015;404:82-90 pubmed publisher
    ..Knockdown of ALK5, ACVR2A/ACVR2B or SMAD4 reversed the effects of GDF8-induced PTX3 suppression...
  2. Satheesh P, Bhattacharya T, Kumar P, Chatterjee R, Dhara S, Paswan C, et al. Gene expression and silencing of activin receptor type 2A (ACVR2A) in myoblast cells of chicken. Br Poult Sci. 2016;57:763-770 pubmed
    b>Activin receptor type 2A (ACVR2A) acts as receptor for myostatin (MSTN) protein involved in inhibiting satellite cell proliferation and differentiation...
  3. Goh B, Singhal V, Herrera A, Tomlinson R, Kim S, Faugere M, et al. Activin receptor type 2A (ACVR2A) functions directly in osteoblasts as a negative regulator of bone mass. J Biol Chem. 2017;292:13809-13822 pubmed publisher
    ..Immunohistochemistry localized ACVR2A and ACVR2B to osteoblasts and osteocytes...
  4. Tsuchida K, Nakatani M, Matsuzaki T, Yamakawa N, Liu Z, Bao Y, et al. Novel factors in regulation of activin signaling. Mol Cell Endocrinol. 2004;225:1-8 pubmed
    ..These data indicate that ARIP2 is a novel factor regulating cell surface ActRII expression and activin function. A novel activin binding protein, follistatin-related gene (FLRG) was identified...
  5. Rossi M, Ionov Y, Bakin A, Cowell J. Truncating mutations in the ACVR2 gene attenuates activin signaling in prostate cancer cells. Cancer Genet Cytogenet. 2005;163:123-9 pubmed
    ..More recently, mutations in the activin type II receptor gene, ACVR2, were identified in colon and pancreatic cell lines and tumors with MSI...
  6. Campregher C, Honeder C, Chung H, Carethers J, Gasche C. Mesalazine reduces mutations in transforming growth factor beta receptor II and activin type II receptor by improvement of replication fidelity in mononucleotide repeats. Clin Cancer Res. 2010;16:1950-6 pubmed publisher
    ..flanking sequences of transforming growth factor beta receptor II (TGFBR2; A10) and activin type II receptor (ACVR2; A8)...
  7. Zeybek B, Celik H, Aydin H, Askar N. Polymorphisms in the activin A receptor type 2A gene affect the onset time and severity of preeclampsia in the Turkish population. J Perinat Med. 2013;41:389-99 pubmed publisher
    ..the possible roles of selected single nucleotide gene polymorphisms (SNPs) of the activin A receptor type 2A (ACVR2A) gene in the pathogenesis of preeclampsia...
  8. Canali S, Core A, Zumbrennen Bullough K, Merkulova M, Wang C, Schneyer A, et al. Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice. Endocrinology. 2016;157:1146-62 pubmed publisher
    ..Activin B stimulates hepcidin via classical activin type II receptors ACVR2A and ACVR2B, noncanonical BMP type I receptors activin receptor-like kinase 2 and activin receptor-like kinase 3, ..
  9. Liu Q, Wang G, Lyu Y, Bai M, Jiapaer Z, Jia W, et al. The miR-590/Acvr2a/Terf1 Axis Regulates Telomere Elongation and Pluripotency of Mouse iPSCs. Stem Cell Reports. 2018;11:88-101 pubmed publisher
    ..Activin receptor II A (Acvr2a) is the downstream target and mediates the function of miR-590...
  10. Raje N, Vallet S. Sotatercept, a soluble activin receptor type 2A IgG-Fc fusion protein for the treatment of anemia and bone loss. Curr Opin Mol Ther. 2010;12:586-97 pubmed
    ..with Celgene Corp, is a chimeric protein containing the extracellular domain of the activin receptor 2A (ACVR2A) fused to the Fc domain of human IgG1...
  11. Abend M, Pfeiffer R, Ruf C, Hatch M, Bogdanova T, Tronko M, et al. Iodine-131 dose dependent gene expression in thyroid cancers and corresponding normal tissues following the Chernobyl accident. PLoS ONE. 2012;7:e39103 pubmed publisher
    ..Eleven of 75 qRT-PCR assayed genes (ACVR2A, AJAP1, CA12, CDK12, FAM38A, GALNT7, LMO3, MTA1, SLC19A1, SLC43A3, ZNF493) were confirmed to have a statistically ..
  12. Ballikaya S, Lee J, Warnken U, Schnölzer M, Gebert J, Kopitz J. De Novo proteome analysis of genetically modified tumor cells by a metabolic labeling/azide-alkyne cycloaddition approach. Mol Cell Proteomics. 2014;13:3446-56 pubmed publisher
    Activin receptor type II (ACVR2) is a member of the transforming growth factor type II receptor family and controls cell growth and differentiation, thereby acting as a tumor suppressor...
  13. Yong H, Murthi P, Kalionis B, Keogh R, Brennecke S. Decidual ACVR2A regulates extravillous trophoblast functions of adhesion, proliferation, migration and invasion in vitro. Pregnancy Hypertens. 2018;12:189-193 pubmed publisher
    ..Our aim was to investigate the role of the pre-eclampsia associated decidual activin receptor, ACVR2A, in regulating trophoblast functions at this interface...
  14. Mencía Castaño I, Curtin C, Duffy G, O Brien F. Harnessing a novel role of miR-16 in osteogenesis for scaffold-based bone tissue engineering. Tissue Eng Part A. 2018;: pubmed publisher
    ..that miR-16 may also play an inhibitory role in osteogenesis due to its ability to directly target Smad5 & AcvR2a. This study thus aimed to assess the potential of miR-16 inhibition to increase osteogenesis in human mesenchymal ..
  15. Williamson R, O Keeffe G, Kenny L. Activin signalling and pre-eclampsia: from genetic risk to pre-symptomatic biomarker. Cytokine. 2015;71:360-5 pubmed publisher
    ..Activin A and its receptor, ACVR2A, have been extensively studied in this regard...
  16. Yamamoto H, Imai K. Microsatellite instability: an update. Arch Toxicol. 2015;89:899-921 pubmed publisher
    ..MSI are involved in various cellular functions, including DNA repair (MSH3 and MSH6), cell signaling (TGFBR2 and ACVR2A), apoptosis (BAX), epigenetic regulation (HDAC2 and ARID1A), and miRNA processing (TARBP2 and XPO5), and a subset ..
  17. Matzuk M, Bradley A. Cloning of the human activin receptor cDNA reveals high evolutionary conservation. Biochim Biophys Acta. 1992;1130:105-8 pubmed
    ..This high degree of conservation of the activin receptor illustrates a strong evolutionary selection and confirms that activin and its receptor play an important role in development. ..
  18. Lebrun J, Vale W. Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation. Mol Cell Biol. 1997;17:1682-91 pubmed
    ..Finally, using cell lines that can be induced to overexpress ActRII and ActRIB or ActRIB only, we show that the inhibin antagonistic effects on activin-induced biological responses ..
  19. Vitt U, Mazerbourg S, Klein C, Hsueh A. Bone morphogenetic protein receptor type II is a receptor for growth differentiation factor-9. Biol Reprod. 2002;67:473-80 pubmed
  20. Grünhagen J, Bhushan R, Degenkolbe E, Jäger M, Knaus P, Mundlos S, et al. MiR-497∼195 cluster microRNAs regulate osteoblast differentiation by targeting BMP signaling. J Bone Miner Res. 2015;30:796-808 pubmed publisher
    ..Predicted targets including Furin, a protease that cleaves pro-forms, genes encoding receptors such as Acvr2a, Bmp1a, Dies1, and Tgfbr3, molecules within the cascade like Smad5, transcriptional regulators like Ski and Zfp423 ..
  21. Jin W, Chen F, Wang K, Song Y, Fei X, Wu B. miR-15a/miR-16 cluster inhibits invasion of prostate cancer cells by suppressing TGF-? signaling pathway. Biomed Pharmacother. 2018;104:637-644 pubmed publisher
    ..MiR-15a/16 targeted and inhibited the expression of endogenous Smad3 and ACVR2A proteins...
  22. Liu Q, Wang G, Chen Y, Li G, Yang D, Kang J. A miR-590/Acvr2a/Rad51b axis regulates DNA damage repair during mESC proliferation. Stem Cell Reports. 2014;3:1103-17 pubmed publisher
    ..miR-590 directly targets Activin receptor type 2a (Acvr2a) to mediate Activin signaling...
  23. Lowery J, Intini G, Gamer L, Lotinun S, Salazar V, Ote S, et al. Loss of BMPR2 leads to high bone mass due to increased osteoblast activity. J Cell Sci. 2015;128:1308-15 pubmed publisher
    ..The type 2 receptors ACVR2A and ACVR2B bind BMPs and activins but the type 2 receptor BMPR2 only binds BMPs, suggesting that type 2 receptor ..
  24. Shoji H, Tsuchida K, Kishi H, Yamakawa N, Matsuzaki T, Liu Z, et al. Identification and characterization of a PDZ protein that interacts with activin type II receptors. J Biol Chem. 2000;275:5485-92 pubmed
    ..These findings suggest that ARIP1 has a significant role in assembling activin signaling molecules at specific subcellular sites and in regulating signal transduction in neuronal cells. ..
  25. Mendelova A, Holubekova V, Grendar M, Zubor P, Svecova I, Loderer D, et al. Association between 3'UTR polymorphisms in genes ACVR2A, AGTR1 and RGS2 and preeclampsia. Gen Physiol Biophys. 2018;37:185-192 pubmed publisher
    ..to investigate whether distribution of three putative regulatory SNPs rs13430086, rs5186, rs4606 in 3'UTR of genes ACVR2A, AGTR1 and RGS2, respectively, that have been associated with hypertension and regulation of trophoblast invasion ..
  26. Horvath L, Bodmer D, Radojevic V, Monge Naldi A. Activin signaling disruption in the cochlea does not influence hearing in adult mice. Audiol Neurootol. 2015;20:51-61 pubmed
    ..Accordingly, activin signaling is involved in the development of the cochlea. Activin binds to its receptor ActRII, then dimerizes with ActRI and induces a signaling pathway resulting in gene expression...
  27. Wang A, Wu L, Lin J, Han L, Bian J, Wu Y, et al. Whole-exome sequencing reveals the origin and evolution of hepato-cholangiocarcinoma. Nat Commun. 2018;9:894 pubmed publisher
    ..Mutated genes identified herein, e.g., VCAN, ACVR2A, and FCGBP, are speculated to contribute to distinct differentiation of HCC and iCCA within H-ChC...
  28. Song R, Catchpoole D, Kennedy P, Li J. Identification of lung cancer miRNA-miRNA co-regulation networks through a progressive data refining approach. J Theor Biol. 2015;380:271-9 pubmed publisher
    ..An example of these functional modules consists of genes SMAD2, ACVR1B, ACVR2A and ACVR2B...
  29. Sasaki S, Ibi T, Matsuhashi T, Takeda K, Ikeda S, Sugimoto M, et al. Genetic variants in the upstream region of activin receptor IIA are associated with female fertility in Japanese Black cattle. BMC Genet. 2015;16:123 pubmed publisher
    ..48476943_48476946insGGC), in the upstream region of the activin receptor IIA gene (ACVR2A) were associated with ANAI4...
  30. Bai L, Chang H, Cheng J, Chu G, Leung P, Yang G. ALK2/ALK3-BMPR2/ACVR2A Mediate BMP2-Induced Downregulation of Pentraxin 3 Expression in Human Granulosa-Lutein Cells. Endocrinology. 2017;158:3501-3511 pubmed publisher
    ..These results improve our understanding of the molecular mechanisms of BMP2 signaling. Our findings suggest that BMP2 may be involved in the regulation of cumulus expansion during the periovulatory stage...
  31. Barbara N, Wrana J, Letarte M. Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily. J Biol Chem. 1999;274:584-94 pubmed
    ..with the TGF-beta type II receptor and interacts with activin-A and BMP-7 via activin type II receptors, ActRII and ActRIIB, regardless of which type I receptor partner is coexpressed...
  32. Shi W, Chang C, Nie S, Xie S, Wan M, Cao X. Endofin acts as a Smad anchor for receptor activation in BMP signaling. J Cell Sci. 2007;120:1216-24 pubmed
    ..Taken together, our results suggest that endofin plays an important role in both positive and negative feedback regulation of the BMP signaling pathway. ..
  33. Allendorph G, Vale W, Choe S. Structure of the ternary signaling complex of a TGF-beta superfamily member. Proc Natl Acad Sci U S A. 2006;103:7643-8 pubmed
    ..bone morphogenetic protein receptor type Ia (BMPR-Ia)-ECD] and its type II receptor [activin receptor type II (ActRII)-ECD] shows two fundamental structural constraints for receptor assembly...
  34. Pande H, Tesfaye D, Hoelker M, Gebremedhn S, Held E, Neuhoff C, et al. MicroRNA-424/503 cluster members regulate bovine granulosa cell proliferation and cell cycle progression by targeting SMAD7 gene through activin signalling pathway. J Ovarian Res. 2018;11:34 pubmed publisher
    ..Luciferase reporter assay showed that SMAD7 and ACVR2A are the direct targets of the miRNA-424/503 cluster members...
  35. Tankó L, Goldhahn J, Varela A, Lesage E, Smith S, Pilling A, et al. Does Activin Receptor Blockade by Bimagrumab (BYM338) Pose Detrimental Effects on Bone Healing in a Rat Fibula Osteotomy Model?. Calcif Tissue Int. 2016;99:310-21 pubmed publisher
    ..antibody that exerts strong promyogenic effects on skeletal muscle by blocking activin type II receptors (ActRII)...
  36. Barrdahl M, Canzian F, Gaudet M, Gapstur S, Trichopoulou A, Tsilidis K, et al. A comprehensive analysis of polymorphic variants in steroid hormone and insulin-like growth factor-1 metabolism and risk of in situ breast cancer: Results from the Breast and Prostate Cancer Cohort Consortium. Int J Cancer. 2017;: pubmed publisher
    ..b>ACVR2A-rs2382112 (ORhom ?=?3.05, 95%CI?=?1.72-5.44, Phom ?=?1...
  37. Totoki Y, Yoshida A, Hosoda F, Nakamura H, Hama N, Ogura K, et al. Unique mutation portraits and frequent COL2A1 gene alteration in chondrosarcoma. Genome Res. 2014;24:1411-20 pubmed publisher
    ..7% of enchondroma cases. Epigenetic regulators (IDH1 and YEATS2) and an activin/BMP signal component (ACVR2A) were recurrently altered...
  38. Hatakeyama S, Summermatter S, Jourdain M, Melly S, Minetti G, Lach Trifilieff E. ActRII blockade protects mice from cancer cachexia and prolongs survival in the presence of anti-cancer treatments. Skelet Muscle. 2016;6:26 pubmed publisher
    ..often receive anti-cancer therapies against their specific cancer type as a standard of care, and whether specific ActRII inhibition is efficacious when combined with anti-cancer agents has not been elucidated yet...
  39. Reichel C, Gmeiner G, Thevis M. Antibody-based strategies for the detection of Luspatercept (ACE-536) in human serum. Drug Test Anal. 2017;9:1721-1730 pubmed publisher
    ..ELISA, which also detected Luspatercept and other ACVR2B-Fc's, but showed no cross-reactivity with Sotatercept/ACVR2A-Fc's. The ELISA might be applied as fast screening tool (100 ?L serum; limit of detection (LOD) ca 15.6 ng/mL)...
  40. Donaldson C, Mathews L, Vale W. Molecular cloning and binding properties of the human type II activin receptor. Biochem Biophys Res Commun. 1992;184:310-6 pubmed
  41. Macias Silva M, Hoodless P, Tang S, Buchwald M, Wrana J. Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2. J Biol Chem. 1998;273:25628-36 pubmed
    ..We show that BMP7 and activin bind to the same type II receptors, ActRII and IIB, but recruit distinct type I receptors into heteromeric receptor complexes...
  42. Chung B, Mullegama S, Marshall C, Lionel A, Weksberg R, Dupuis L, et al. Severe intellectual disability and autistic features associated with microduplication 2q23.1. Eur J Hum Genet. 2012;20:398-403 pubmed publisher
    ..The duplications include one OMIM Morbid Map gene, MBD5, as well as seven known RefSeq genes (ACVR2A, ORC4L, EPC2, KIF5C, MIR1978, LYPD6B, and LYPD6). MBD5 lies in the minimum area of overlap of the 2q23...
  43. Morvan F, Rondeau J, Zou C, Minetti G, Scheufler C, Scharenberg M, et al. Blockade of activin type II receptors with a dual anti-ActRIIA/IIB antibody is critical to promote maximal skeletal muscle hypertrophy. Proc Natl Acad Sci U S A. 2017;114:12448-12453 pubmed publisher
    ..manner at the critical myostatin/activin binding site, hence preventing signal transduction through either ActRII. Myostatin and the activins are capable of binding to both ActRIIA and ActRIIB, with different affinities...
  44. Jones J, Cadena S, Gong C, Wang X, Chen Z, Wang S, et al. Supraphysiologic Administration of GDF11 Induces Cachexia in Part by Upregulating GDF15. Cell Rep. 2018;22:1522-1530 pubmed publisher
    ..Inhibition of GDF15 can restore appetite but cannot restore the GDF11-induced loss of muscle mass, which requires blockade of ActRII signaling. These findings are relevant for treatment of cachexia.
  45. Lewis K, Gray P, Blount A, MacConell L, Wiater E, Bilezikjian L, et al. Betaglycan binds inhibin and can mediate functional antagonism of activin signalling. Nature. 2000;404:411-4 pubmed
    ..Activins bind specific type II receptor serine kinases (ActRII or IIB) to promote the recruitment and phosphorylation of the type I receptor serine kinase, ALK4 (refs 7-9), ..
  46. Tougeron D, Fauquembergue E, Rouquette A, Le Pessot F, Sesboué R, Laurent M, et al. Tumor-infiltrating lymphocytes in colorectal cancers with microsatellite instability are correlated with the number and spectrum of frameshift mutations. Mod Pathol. 2009;22:1186-95 pubmed publisher
    ..The four most frequently mutated genes were ACVR2 (92%), TAF1B (84%), ASTE1/HT001 (80%) and TGFBR2 (77%)...
  47. Seher A, Lagler C, Stühmer T, Müller Richter U, Kübler A, Sebald W, et al. Utilizing BMP-2 muteins for treatment of multiple myeloma. PLoS ONE. 2017;12:e0174884 pubmed publisher
    ..activities are counteracted by Activin A, we analysed whether BMP2, which also binds to the Activin A receptors ActRII and ActRIIB but activates the alternative SMAD-1/5/8 pathway, can be used to antagonize Activin A activities, such ..
  48. Adapala N, Kim H. A genome-wide transcriptomic analysis of articular cartilage during normal maturation in pigs. Gene. 2017;627:508-518 pubmed publisher
    ..g. BMPR1A, BMPR2, ACVR2, periostin, SFRP2, COL5A3) and regulation of blood vessel size (e.g...
  49. Upton P, Davies R, Trembath R, Morrell N. Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells. J Biol Chem. 2009;284:15794-804 pubmed publisher
    ..This differential signaling may contribute to the contrasting pathologies of hereditary hemorrhagic telangiectasia and pulmonary arterial hypertension. ..
  50. Ferreira L, Gomes C, Araújo A, Bezerra P, Duggal P, Jeronimo S. Association between ACVR2A and early-onset preeclampsia: replication study in a Northeastern Brazilian population. Placenta. 2015;36:186-90 pubmed publisher
    ..The gene Activin A receptor, type IIA (ACVR2A), was reported as associated to preeclampsia in Australian/New Zealand and Norwegian populations...
  51. Thulluru H, Michel O, Oudejans C, van Dijk M. ACVR2A promoter polymorphism rs1424954 in the Activin-A signaling pathway in trophoblasts. Placenta. 2015;36:345-9 pubmed publisher
    ..A polymorphism located in the promoter region of ACVR2A (rs1424954 (A > G)) has previously been shown to be significantly associated with pre-eclampsia...
  52. Yong H, Murthi P, Wong M, Kalionis B, Cartwright J, Brennecke S, et al. Effects of normal and high circulating concentrations of activin A on vascular endothelial cell functions and vasoactive factor production. Pregnancy Hypertens. 2015;5:346-53 pubmed publisher
    ..Immunostaining demonstrated the presence of the activin A receptor, ACVR2A, in SGHEC-7 cells used to model the vascular endothelium...
  53. DEAN M, Davis D, Burdette J. Activin A stimulates migration of the fallopian tube epithelium, an origin of high-grade serous ovarian cancer, through non-canonical signaling. Cancer Lett. 2017;391:114-124 pubmed publisher
    ..In Oncomine, transcripts for the activin A receptors (ACVR1B and ACVR2A) were higher in serous tumors relative to the normal ovary, while inhibitors of activin A signaling (INHA and ..
  54. Mathews L, Vale W. Expression cloning of an activin receptor, a predicted transmembrane serine kinase. Cell. 1991;65:973-82 pubmed
    ..elegans daf-1 gene product, a putative transmembrane serine/threonine-specific protein kinase for which the ligand is not known. ..
  55. Attisano L, Carcamo J, Ventura F, Weis F, Massague J, Wrana J. Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors. Cell. 1993;75:671-80 pubmed
    ..The results indicate that type I receptors are transmembrane protein kinases that associate with type II receptors to generate diverse heteromeric serine/threonine kinase complexes of different signaling capacities. ..
  56. Walton K, Makanji Y, Robertson D, Harrison C. The synthesis and secretion of inhibins. Vitam Horm. 2011;85:149-84 pubmed publisher
    ..Propeptides may increase the half-life of inhibin A and B in circulation, but they are readily displaced in the presence of the high-affinity receptors, betaglycan, and ActRII.
  57. Wu F, Lin T, Sung L, Chang W, Wu P, Luo C. BMP8A sustains spermatogenesis by activating both SMAD1/5/8 and SMAD2/3 in spermatogonia. Sci Signal. 2017;10: pubmed publisher
    ..mouse spermatogonia, BMP8A activated SMAD1/5/8 through receptor complexes formed by ALK3 and either ACVR2A or BMPR2 and activated SMAD2/3 through receptor complexes formed by ALK5 and ACVR2A, ACVR2B, or TGFBR2...
  58. Valdecantos P, Bravo Miana R, García E, García D, Roldán Olarte M, Miceli D. Expression of bone morphogenetic protein receptors in bovine oviductal epithelial cells: Evidence of autocrine BMP signaling. Anim Reprod Sci. 2017;185:89-96 pubmed publisher
    ..RT-qPCR was used to analyze the mRNA abundance of BMP type I (BMPR1A, BMPR1B, ACVR1) and type II receptors (BMPR2, ACVR2A, ACVR2B) in the bovine oviduct epithelial cells (BOEC) isolated from ampulla and isthmus at both the follicular (..
  59. Dillenburg A, Ireland G, Holloway R, Davies C, Evans F, Swire M, et al. Activin receptors regulate the oligodendrocyte lineage in health and disease. Acta Neuropathol. 2018;135:887-906 pubmed publisher
    ..These processes were found to be dependent on the activin receptor subtype Acvr2a, which is expressed during oligodendrocyte differentiation and axonal ensheathment in development and following ..
  60. Casagrandi D, Bearfield C, Geary J, Redman C, Muttukrishna S. Inhibin, activin, follistatin, activin receptors and beta-glycan gene expression in the placental tissue of patients with pre-eclampsia. Mol Hum Reprod. 2003;9:199-203 pubmed
    ..The mechanism(s) involved in increased gene expression in pre-eclampsia is as yet unclear. ..
  61. Wang S, Liu J, Li X, Ji X, Zhang J, Wang Y, et al. MiR-125b Regulates Primordial Follicle Assembly by Targeting Activin Receptor Type 2a in Neonatal Mouse Ovary. Biol Reprod. 2016;94:83 pubmed publisher
    ..the activin/Smad2 signaling in neonatal mouse ovary by directly targeting the 3'-untranslated region of activin receptor type 2a (Acvr2a)...
  62. Peng C, Huang T, Jeung E, Donaldson C, Vale W, Leung P. Expression of the type II activin receptor gene in the human placenta. Endocrinology. 1993;133:3046-9 pubmed
    ..In the present study, we examined the expression of the gene encoding activin type II receptor (ActRII) in this tissue...
  63. Schulte K, Jonas C, Krebs R, Roher H. Activin A and activin receptors in the human thyroid: a link to the female predominance of goiter?. Horm Metab Res. 2000;32:390-400 pubmed
    ..TGFbeta-receptor type I and II, activin receptors type I receptors alk2 and alk4, and activin type II receptors actRII and actRIIb...
  64. Harrison C, Gray P, Koerber S, Fischer W, Vale W. Identification of a functional binding site for activin on the type I receptor ALK4. J Biol Chem. 2003;278:21129-35 pubmed
    ..by assembling a complex of two types of transmembrane serine/threonine receptor kinases classified as type II (ActRII or ActRIIB) and type I (ALK4)...
  65. Chen D, Zhao M, Mundy G. Bone morphogenetic proteins. Growth Factors. 2004;22:233-41 pubmed
    ..A significant advancement about the understanding of in vivo functions of BMP ligands, receptors and signaling molecules has been achieved in recent years. ..
  66. You K, Li L, Kim N, Kang H, Koh K, Chwae Y, et al. Selective translational repression of truncated proteins from frameshift mutation-derived mRNAs in tumors. PLoS Biol. 2007;5:e109 pubmed
    ..Our findings suggest a novel mechanism of gene expression regulation for PTC-containing mRNAs in which the deleterious transcripts are regulated either by NMD or translational repression. ..
  67. Xia Y, Yu P, Sidis Y, Beppu H, Bloch K, Schneyer A, et al. Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4. J Biol Chem. 2007;282:18129-40 pubmed
    ..These findings suggest that RGMa facilitates the use of ActRIIA by endogenous BMP2 and BMP4 ligands that otherwise prefer signaling via BMPRII and that increased utilization of ActRIIA leads to generation of an enhanced BMP signal. ..
  68. Carrarelli P, Yen C, Arcuri F, Funghi L, Tosti C, Wang T, et al. Myostatin, follistatin and activin type II receptors are highly expressed in adenomyosis. Fertil Steril. 2015;104:744-52.e1 pubmed publisher
    ..The augmented expression of ActRIIa, ActRIIb, and follistatin in the endometrium of these patients may play a role in adenomyosis-related infertility. ..
  69. Walpurgis K, Thomas A, Dellanna F, Schanzer W, Thevis M. Detection of the Human Anti-ActRII Antibody Bimagrumab in Serum by Means of Affinity Purification, Tryptic Digestion, and LC-HRMS. Proteomics Clin Appl. 2017;: pubmed publisher
    Inhibitors of the ActRII signaling pathways represent promising therapeutics for the treatment of muscular diseases, but also pose risks as performance-enhancing agents in sports...
  70. Chapman S, Bernard D, Jelen J, Woodruff T. Properties of inhibin binding to betaglycan, InhBP/p120 and the activin type II receptors. Mol Cell Endocrinol. 2002;196:79-93 pubmed
    ..Thus, it appears that the mechanisms of inhibin action may vary depending on the ligand and receptor types involved. ..
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    ..This increases the understanding of the underlying biology of BMP9 activation and also provides guidance for ELISA development for the detection of circulating BMP9 variants. ..
  73. Yong H, Murthi P, Brennecke S, Moses E. Genetic Approaches in Preeclampsia. Methods Mol Biol. 2018;1710:53-72 pubmed publisher
    ..Such studies have identified some promising candidate genes such as STOX1 and ACVR2A. Nevertheless, researchers face ongoing challenges of replicating these genetic associations in different ..
  74. Yamakawa N, Tsuchida K, Sugino H. The rasGAP-binding protein, Dok-1, mediates activin signaling via serine/threonine kinase receptors. EMBO J. 2002;21:1684-94 pubmed
    ..These findings indicate that Dok-1 acts as an adaptor protein that links the activin receptors with the Smads, suggesting a novel function for Dok-1 in activin signaling leading to B-cell apoptosis. ..
  75. Lambert Messerlian G, Eklund E, Pinar H, Tantravahi U, Schneyer A. Activin subunit and receptor expression in normal and cleft human fetal palate tissues. Pediatr Dev Pathol. 2007;10:436-45 pubmed
    ..Inhibin/activin BA subunit, follistatin, and activin receptor proteins and mRNAs are present in the human fetal palate. These data suggest that activin signalling has the potential to be associated with human palate development. ..
  76. Chung H, Chaudhry J, Lai J, Young D, Carethers J. Flanking nucleotide specificity for DNA mismatch repair-deficient frameshifts within activin receptor 2 (ACVR2). Mutat Res. 2012;729:73-80 pubmed publisher
    We previously demonstrated that exonic selectivity for frameshift mutation (exon 10 over exon 3) of ACVR2 in mismatch repair (MMR)-deficient cells is partially determined by 6 nucleotides flanking 5' and 3' of each microsatellite...
  77. Volik S, Raphael B, Huang G, Stratton M, Bignel G, Murnane J, et al. Decoding the fine-scale structure of a breast cancer genome and transcriptome. Genome Res. 2006;16:394-404 pubmed
    ..Given these properties, ESP could play an important role in a tumor genome project. ..
  78. Torres P, Florio P, Galleri L, Reis F, Borges L, Petraglia F. Activin A, activin receptor type II, nodal, and cripto mRNA are expressed by eutopic and ectopic endometrium in women with ovarian endometriosis. Reprod Sci. 2009;16:727-33 pubmed publisher
    ..protein that regulates endometrial functions by signaling at its receptors, namely type I (ActRI) and type II (ActRII)...
  79. Adams M, Kerlavage A, Fields C, Venter J. 3,400 new expressed sequence tags identify diversity of transcripts in human brain. Nat Genet. 1993;4:256-67 pubmed
    ..About half of the ESTs predicted to contain a protein-coding region have no matches in the public peptide databases and may represent new gene families. ..
  80. Attisano L, Wrana J, Montalvo E, Massague J. Activation of signalling by the activin receptor complex. Mol Cell Biol. 1996;16:1066-73 pubmed
    ..The evidence suggests that ActR-IIB acts as a primary activin receptor and ActR-IB acts as a downstream transducer of activin signals. ..
  81. D Abronzo F, Swearingen B, Klibanski A, Alexander J. Mutational analysis of activin/transforming growth factor-beta type I and type II receptor kinases in human pituitary tumors. J Clin Endocrinol Metab. 1999;84:1716-21 pubmed
    ..No other mutations were detected in any tumor studied. These data suggest that somatic mutations within these intracellular kinase regions of type I/type II receptors are rare in human pituitary tumors. ..
  82. Perlman R, Schiemann W, Brooks M, Lodish H, Weinberg R. TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation. Nat Cell Biol. 2001;3:708-14 pubmed
    ..Our findings associate Daxx directly with the TGF-beta apoptotic-signalling pathway, and make a biochemical connection between the receptors for TGF-beta and the apoptotic machinery. ..
  83. Lux A, Beil C, Majety M, Barron S, Gallione C, Kuhn H, et al. Human retroviral gag- and gag-pol-like proteins interact with the transforming growth factor-beta receptor activin receptor-like kinase 1. J Biol Chem. 2005;280:8482-93 pubmed
    ..This is the first report of a human retroviral-like protein interacting with members of the TGF-beta receptor family. ..
  84. Xia Y, Babitt J, Sidis Y, Chung R, Lin H. Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin. Blood. 2008;111:5195-204 pubmed publisher
    ..Thus, HJV-mediated BMP signaling and hepcidin regulation occur via a distinct subset of BMP ligands and BMP receptors, independently of neogenin. ..
  85. Lavery K, Swain P, Falb D, Alaoui Ismaili M. BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells. J Biol Chem. 2008;283:20948-58 pubmed publisher
    ..BMP activities in hMSC are elicited through the type I receptors ACVR1A and BMPR1A and the type II receptors ACVR2A and BMPR2...
  86. Schwaerzer G, Hiepen C, Schrewe H, Nickel J, Ploeger F, Sebald W, et al. New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance. J Bone Miner Res. 2012;27:429-42 pubmed publisher
    ..such as noggin counteract BMP signaling by covering the ligand's BMP type I (BMPRI) and type II (BMPRII, ActRII, ActRIIB) interaction sites...
  87. Miller M, Lambert Messerlian G, Eklund E, Heath N, Donahue J, Stopa E. Expression of inhibin/activin proteins and receptors in the human hypothalamus and basal forebrain. J Neuroendocrinol. 2012;24:962-72 pubmed publisher
    ..These studies show for the first time that the inhibin/activin protein subunits and receptors can be co-localised in the human brain, implicating potential, diverse neural functions. ..
  88. de Winter J, de Vries C, van Achterberg T, Ameerun R, Feijen A, Sugino H, et al. Truncated activin type II receptors inhibit bioactivity by the formation of heteromeric complexes with activin type I. receptors. Exp Cell Res. 1996;224:323-34 pubmed
    ..Furthermore, our data indicate that truncated type IIA receptors can interact with other type I receptors and as such might inhibit signal transduction by type I receptors other than activin type IA and type IB receptors. ..
  89. Martens J, de Winter J, Timmerman M, McLuskey A, van Schaik R, Themmen A, et al. Inhibin interferes with activin signaling at the level of the activin receptor complex in Chinese hamster ovary cells. Endocrinology. 1997;138:2928-36 pubmed
    ..In conclusion, these data show that in Chinese hamster ovary cells inhibin acts directly at the activin receptor complex, most likely through displacement of activin from the activin type II receptor. ..
  90. Lebrun J, Takabe K, Chen Y, Vale W. Roles of pathway-specific and inhibitory Smads in activin receptor signaling. Mol Endocrinol. 1999;13:15-23 pubmed
    ..Finally, we show that the inhibitory Smad7 can prevent the association of the two pathway-specific Smads with the activin receptor complex, thereby blocking the activin signal. ..
  91. Bondestam J, Horelli Kuitunen N, Hilden K, Ritvos O, Aaltonen J. Assignment of ACVR2 and ACVR2B the human activin receptor type II and IIB genes to chromosome bands 2q22.2-->q23.3 and 3p22 and the human follistatin gene (FST) to chromosome 5q11.2 by FISH. Cytogenet Cell Genet. 1999;87:219-20 pubmed
  92. Chapman S, Woodruff T. Modulation of activin signal transduction by inhibin B and inhibin-binding protein (INhBP). Mol Endocrinol. 2001;15:668-79 pubmed
    ..These findings suggest that InhBP is an inhibin B-specific receptor that mediates antagonism of activin signal transduction through the modulation of activin heteromeric receptor complex assembly. ..