actin

Summary

Gene Symbol: actin
Description: actin, alpha 1, skeletal muscle
Alias: ACTA, ASMA, CFTD, CFTD1, CFTDM, MPFD, NEM1, NEM2, NEM3, SHPM, actin, alpha skeletal muscle, nemaline myopathy type 3
Species: human
Products:     actin

Top Publications

  1. Weed S, Karginov A, Schafer D, Weaver A, Kinley A, Cooper J, et al. Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 complex. J Cell Biol. 2000;151:29-40 pubmed
    Cortactin is an actin-binding protein that is enriched within the lamellipodia of motile cells and in neuronal growth cones...
  2. Shoeman R, Kesselmier C, Mothes E, Höner B, Traub P. Non-viral cellular substrates for human immunodeficiency virus type 1 protease. FEBS Lett. 1991;278:199-203 pubmed
    ..Of these 10 proteins (actin, alpha-actinin, spectrin, tropomyosins, vinculin, dystrophin, MAP-2, villin, TRK-1 and Ig mu-chain), we show that ..
  3. Liu B, Dai R, Tian C, Dawson L, Gorelick R, Yu X. Interaction of the human immunodeficiency virus type 1 nucleocapsid with actin. J Virol. 1999;73:2901-8 pubmed
    ..Monoclonal antibody against actin coimmunoprecipitated full-length Gag and p6(Gag) domain-truncated Gag molecules from cell lysates but failed to ..
  4. Philimonenko V, Zhao J, Iben S, Dingová H, Kysela K, Kahle M, et al. Nuclear actin and myosin I are required for RNA polymerase I transcription. Nat Cell Biol. 2004;6:1165-72 pubmed
    The presence of actin and nuclear myosin I (NMI) in the nucleus suggests a role for these motor proteins in nuclear functions...
  5. Yoder A, Yu D, Dong L, Iyer S, Xu X, Kelly J, et al. HIV envelope-CXCR4 signaling activates cofilin to overcome cortical actin restriction in resting CD4 T cells. Cell. 2008;134:782-92 pubmed publisher
    ..We find that static cortical actin in resting T cells represents a restriction and that HIV utilizes the Galphai-dependent signaling from the ..
  6. Spear M, Guo J, Wu Y. The trinity of the cortical actin in the initiation of HIV-1 infection. Retrovirology. 2012;9:45 pubmed publisher
    For an infecting viral pathogen, the actin cortex inside the host cell is the first line of intracellular components that it encounters. Viruses devise various strategies to actively engage or circumvent the actin structure...
  7. Wu H, Parsons J. Cortactin, an 80/85-kilodalton pp60src substrate, is a filamentous actin-binding protein enriched in the cell cortex. J Cell Biol. 1993;120:1417-26 pubmed
    ..The carboxyl-terminal half contains a distal SH3 domain. We report that cortactin is an F-actin-binding protein. The binding to F-actin is specific and saturable...
  8. Wu R, Gu Y, Xu Y, Mitola S, Bussolino F, Terada L. Human immunodeficiency virus type 1 Tat regulates endothelial cell actin cytoskeletal dynamics through PAK1 activation and oxidant production. J Virol. 2004;78:779-89 pubmed
    ..rearrangement during angiogenesis, we investigated the specific effects of Tat on the endothelial cell actin cytoskeleton...
  9. Readinger J, Schiralli G, Jiang J, Thomas C, August A, Henderson A, et al. Selective targeting of ITK blocks multiple steps of HIV replication. Proc Natl Acad Sci U S A. 2008;105:6684-9 pubmed publisher
    ..cell receptor (TCR)-induced activation of PLCgamma-1, Ca(2+) mobilization and transcription factor activation, and actin rearrangement downstream of both TCR and chemokine receptors...

More Information

Publications102 found, 100 shown here

  1. Gladnikoff M, Shimoni E, Gov N, Rousso I. Retroviral assembly and budding occur through an actin-driven mechanism. Biophys J. 2009;97:2419-28 pubmed publisher
    ..electron microscopy, we find that both human immunodeficiency virus and Moloney murine leukemia virus remodel the actin cytoskeleton of their host...
  2. Stolp B, Fackler O. How HIV takes advantage of the cytoskeleton in entry and replication. Viruses. 2011;3:293-311 pubmed publisher
    ..the human immunodeficiency virus type 1 (HIV-1) has evolved strategies to exploit and modulate in particular the actin cytoskeleton for its purposes...
  3. Rey O, Canon J, Krogstad P. HIV-1 Gag protein associates with F-actin present in microfilaments. Virology. 1996;220:530-4 pubmed
    ..In vivo and in vitro analyses of this interaction indicated that the unprocessed Gag polyprotein is capable of association with polymerized actin (F-actin). Binding of Gag to F-actin may be involved in the assembly or budding of HIV-1.
  4. Ohtsuka T, Nakanishi H, Ikeda W, Satoh A, Momose Y, Nishioka H, et al. Nexilin: a novel actin filament-binding protein localized at cell-matrix adherens junction. J Cell Biol. 1998;143:1227-38 pubmed
    We isolated two novel actin filament (F-actin)-binding proteins from rat brain and rat 3Y1 fibroblast. They were splicing variants, and we named brain big one b-nexilin and fibroblast small one s-nexilin...
  5. Jolly C, Mitar I, Sattentau Q. Requirement for an intact T-cell actin and tubulin cytoskeleton for efficient assembly and spread of human immunodeficiency virus type 1. J Virol. 2007;81:5547-60 pubmed
    ..Treatment of infected T cells with inhibitors of actin or tubulin remodeling disrupted Gag and Env compartmentalization within the polarized raft-like domains...
  6. Stolp B, Abraham L, Rudolph J, Fackler O. Lentiviral Nef proteins utilize PAK2-mediated deregulation of cofilin as a general strategy to interfere with actin remodeling. J Virol. 2010;84:3935-48 pubmed publisher
    ..Mechanistic analysis revealed that this interaction results in deregulation of the actin-severing factor cofilin and thus blocks the chemokine-mediated actin remodeling required for cell motility...
  7. Ott D, Coren L, Kane B, Busch L, Johnson D, Sowder R, et al. Cytoskeletal proteins inside human immunodeficiency virus type 1 virions. J Virol. 1996;70:7734-43 pubmed
    ..of cytoskeletal proteins are present in virions at different concentrations relative to the molar level of Gag: actin (approximately 10 to 15%), ezrin and moesin (approximately 2%), and cofilin (approximately 2 to 10%)...
  8. Itoh M, Nagafuchi A, Moroi S, Tsukita S. Involvement of ZO-1 in cadherin-based cell adhesion through its direct binding to alpha catenin and actin filaments. J Cell Biol. 1997;138:181-92 pubmed
    ..In contrast, C-ZO-1 was localized along actin stress fibers...
  9. Kobayashi K, Kuroda S, Fukata M, Nakamura T, Nagase T, Nomura N, et al. p140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase. J Biol Chem. 1998;273:291-5 pubmed
    ..Rac1, but not the mutants unable to bind Rac1, were colocalized with dominant active Rac1(Val-12) and cortical actin filament at the Rac1(Val-12)-induced membrane ruffling area in KB cells...
  10. Wilk T, Gowen B, Fuller S. Actin associates with the nucleocapsid domain of the human immunodeficiency virus Gag polyprotein. J Virol. 1999;73:1931-40 pubmed
    Recently, it was shown that actin molecules are present in human immunodeficiency virus type 1 (HIV-1) particles...
  11. Llorca O, Martin Benito J, Gomez Puertas P, Ritco Vonsovici M, Willison K, Carrascosa J, et al. Analysis of the interaction between the eukaryotic chaperonin CCT and its substrates actin and tubulin. J Struct Biol. 2001;135:205-18 pubmed
    ..has been described for the eukaryotic chaperonin CCT, which interacts mainly with the cytoskeletal proteins actin and tubulin...
  12. Obaishi H, Nakanishi H, Mandai K, Satoh K, Satoh A, Takahashi K, et al. Frabin, a novel FGD1-related actin filament-binding protein capable of changing cell shape and activating c-Jun N-terminal kinase. J Biol Chem. 1998;273:18697-700 pubmed
    We purified from rat brain a novel F-actin-binding protein with a Mr of about 105,000 (p105), which was estimated by SDS-polyacrylamide gel electrophoresis. We cloned its cDNA from a rat brain cDNA library and characterized it...
  13. Fanning A, Jameson B, Jesaitis L, Anderson J. The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton. J Biol Chem. 1998;273:29745-53 pubmed
    ..to interact with the transmembrane protein occludin, a second tight junction-specific MAGUK, ZO-2, and F-actin, although the nature and functional significance of these interactions is poorly understood...
  14. Bukrinskaya A, Brichacek B, Mann A, Stevenson M. Establishment of a functional human immunodeficiency virus type 1 (HIV-1) reverse transcription complex involves the cytoskeleton. J Exp Med. 1998;188:2113-25 pubmed
    ..Interruption of actin polymerization before virus infection reduced association of viral reverse transcription complexes with the ..
  15. Ibarrondo F, Choi R, Geng Y, Canon J, Rey O, Baldwin G, et al. HIV type 1 Gag and nucleocapsid proteins: cytoskeletal localization and effects on cell motility. AIDS Res Hum Retroviruses. 2001;17:1489-500 pubmed
    ..On the basis of observations indicating an interaction between HIV-1 Gag and target cell filamentous actin, we hypothesized that these interactions would promote cell motility of HIV-infected cells...
  16. Vasiliver Shamis G, Cho M, Hioe C, Dustin M. Human immunodeficiency virus type 1 envelope gp120-induced partial T-cell receptor signaling creates an F-actin-depleted zone in the virological synapse. J Virol. 2009;83:11341-55 pubmed publisher
    ..shows that HIV-1 gp120 interaction with its receptors is initially organized into microclusters that undergo F-actin-dependent consolidation into a central supramolecular activation complex (cSMAC)...
  17. Gordón Alonso M, Rocha Perugini V, Alvarez S, Moreno Gonzalo O, Ursa A, López Martín S, et al. The PDZ-adaptor protein syntenin-1 regulates HIV-1 entry. Mol Biol Cell. 2012;23:2253-63 pubmed publisher
    ..receptor and coreceptor, CD4/CXCR4, and cellular structures toward the virus contact area, and triggers local actin polymerization and phosphatidylinositol 4,5-bisphosphate (PIP(2)) production, which are needed for successful HIV ..
  18. Warrilow D, Harrich D. HIV-1 replication from after cell entry to the nuclear periphery. Curr HIV Res. 2007;5:293-9 pubmed
    ..After entering the cell, the virion interacts initially with actin filaments which assist binding to microtubles enabling transport to the nuclear periphery...
  19. Osman K, Samir A, Abo Shama U, Mohamed E, Orabi A, Zolnikov T. Determination of virulence and antibiotic resistance pattern of biofilm producing Listeria species isolated from retail raw milk. BMC Microbiol. 2016;16:263 pubmed
    ..The virulence-associated genes, hlyA, plcB, actA and iap associated with Listeria were molecularly assayed. The 17 isolated Listeria spp...
  20. Ohri M, Parashar S, Pai V, Ghosh S, Chakraborti A. A cytosol derived factor of Group B streptococcus prevent its invasion into human epithelial cells. World J Microbiol Biotechnol. 2018;34:45 pubmed publisher
    ..a combination of sequential purification steps involving molecular sieving and ion exchange chromatography using ACTA-FPLC system...
  21. Basu P, Alibhai F, Tsimakouridze E, Singh R, Paglialunga S, Holloway G, et al. Male-Specific Cardiac Dysfunction in CTP:Phosphoethanolamine Cytidylyltransferase (Pcyt2)-Deficient Mice. Mol Cell Biol. 2015;35:2641-57 pubmed publisher
    ..heart phospholipids but have reduced heart triglyceride levels and altered expression of the structural genes Acta (low) and Myh7 (high)...
  22. Rychli K, Grunert T, Ciolacu L, Zaiser A, Razzazi Fazeli E, Schmitz Esser S, et al. Exoproteome analysis reveals higher abundance of proteins linked to alkaline stress in persistent Listeria monocytogenes strains. Int J Food Microbiol. 2016;218:17-26 pubmed publisher
    ..Concurrently we found higher expression of proteins involved in virulence in EGDe e.g. the actin-assembly-inducing protein ActA and the surface virulence associated protein SvpA...
  23. Wu L, Feyerabend F, Schilling A, Willumeit Römer R, Luthringer B. Effects of extracellular magnesium extract on the proliferation and differentiation of human osteoblasts and osteoclasts in coculture. Acta Biomater. 2015;27:294-304 pubmed publisher
    ..The submitted work could be of significant importance to other researchers working in the related field(s), thus appealing to the readership of Acta Biomaterialia.
  24. Miyatake S, Mitsuhashi S, Hayashi Y, Purevjav E, Nishikawa A, Koshimizu E, et al. Biallelic Mutations in MYPN, Encoding Myopalladin, Are Associated with Childhood-Onset, Slowly Progressive Nemaline Myopathy. Am J Hum Genet. 2017;100:169-178 pubmed publisher
    ..Our results suggest that MYPN screening should be considered in individuals with mild NM, especially when cardiac problems or intranuclear rods are present. ..
  25. Bramham J, Hodgkinson J, Smith B, Uhrin D, Barlow P, Winder S. Solution structure of the calponin CH domain and fitting to the 3D-helical reconstruction of F-actin:calponin. Structure. 2002;10:249-58 pubmed
    Calponin is involved in the regulation of contractility and organization of the actin cytoskeleton in smooth muscle cells...
  26. Kehat I, Accornero F, Aronow B, Molkentin J. Modulation of chromatin position and gene expression by HDAC4 interaction with nucleoporins. J Cell Biol. 2011;193:21-9 pubmed publisher
    ..We thus propose a novel mechanism of action for HDAC4, suggesting it can function to dynamically regulate gene expression through changes in chromatin-nucleoporin association. ..
  27. Antonietti P, Gessler F, Düssmann H, Reimertz C, Mittelbronn M, Prehn J, et al. AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy irrespective of expression levels and the subcellular localization of Bcl-xL and Bcl-2 in MCF7 cells. Biochim Biophys Acta. 2016;1863:499-509 pubmed publisher
    ..This was also observed with the organelle-specific variants Bcl-xL-ActA and Bcl-2-ActA (mitochondrial) as well as Bcl-xL-cb5 and Bcl-2-cb5 (ER) which all reduced AT-101-induced cell death,..
  28. Bitting C, Hanson J. Navajo Neurohepatopathy?: A Case Report and Literature Review Emphasizing Clinicopathologic Diagnosis. Acta Gastroenterol Belg. 2016;79:463-469 pubmed
    ..A comprehensive literature review is provided to assist in diagnosis and management of NNH. (Acta gastroenterol. belg., 2016, 79, 463-469).
  29. van Stokkum I, Gwizdala M, Tian L, Snellenburg J, van Grondelle R, van Amerongen H, et al. A functional compartmental model of the Synechocystis PCC 6803 phycobilisome. Photosynth Res. 2018;135:87-102 pubmed publisher
    ..Biochim Biophys Acta 1787(4):272-279, 2009). The rods and core contain phycocyanin and allophycocyanin pigments, respectively...
  30. Quirnheim Pais D, Rathmann B, Koepke J, Tomova C, Wurzinger P, Thielmann Y. A standardized technique for high-pressure cooling of protein crystals. Acta Crystallogr D Struct Biol. 2017;73:997-1006 pubmed publisher
    ..1973). Acta Cryst. A29, 263-265]...
  31. Nakamura T, Takeuchi K, Muraoka S, Takezoe H, Takahashi N, Mori N. A neurally enriched coronin-like protein, ClipinC, is a novel candidate for an actin cytoskeleton-cortical membrane-linking protein. J Biol Chem. 1999;274:13322-7 pubmed
    Brain-enriched human FC96 protein shows a close sequence similarity to the Dictyostelium actin-binding protein coronin, which has been implicated in cell motility, cytokinesis, and phagocytosis...
  32. Licastro F, Chiappelli M, Porcellini E, Campo G, Buscema M, Grossi E, et al. Gene-gene and gene - clinical factors interaction in acute myocardial infarction: a new detailed risk chart. Curr Pharm Des. 2010;16:783-8 pubmed
    ..These analyses suggested that genotypes of few inflammatory genes, a SNP in HMGCR gene, middle age, gender, low HDL and diabetes were very informative variables to predict the risk of AMI. ..
  33. Reva I. Comment on "Density functional theory studies on molecular structure, vibrational spectra and electronic properties of cyanuric acid". Spectrochim Acta A Mol Biomol Spectrosc. 2015;151:232-6 pubmed publisher
    In a recently published paper [Spectrochim. Acta A: Mol. Biomol. Spect...
  34. Yang Z, Liu T, Xie Y, Sun Z, Liu H, Lin J, et al. Chitosan layered gold nanorods as synergistic therapeutics for photothermal ablation and gene silencing in triple-negative breast cancer. Acta Biomater. 2015;25:194-204 pubmed publisher
    ..The research has not been disclosed or published and is not under consideration for publication elsewhere. We would appreciate if the manuscript could be reviewed and considered for publication in Acta BIOMATERIALIA.
  35. Amann A, Zwierzina M, Koeck S, Gamerith G, Pechriggl E, Huber J, et al. Development of a 3D angiogenesis model to study tumour - endothelial cell interactions and the effects of anti-angiogenic drugs. Sci Rep. 2017;7:2963 pubmed publisher
    ..An up-regulation of hypoxia and vimentin, ASMA and a downregulation of E-cadherin were observed in co- and tri-cultures compared to monocultures...
  36. Zukosky K, Meilleur K, Traynor B, Dastgir J, Medne L, Devoto M, et al. Association of a Novel ACTA1 Mutation With a Dominant Progressive Scapuloperoneal Myopathy in an Extended Family. JAMA Neurol. 2015;72:689-98 pubmed publisher
    ..A highly conserved protein, ACTA1 is implicated in multiple muscle diseases, including nemaline myopathy, actin aggregate myopathy, fiber-type disproportion, and rod-core myopathy...
  37. Mancilla Hernández E, Medina Ávalos M, Barnica Alvarado R, Soto Candia D, Guerrero Venegas R, Zecua Nájera Y. [Prevalence of asthma and determination of symptoms as risk indicators]. Rev Alerg Mex. 2015;62:271-8 pubmed
    ..Antecedentes: el asma es una enfermedad inflamatoria crónica de las vías aéreas, su prevalencia se ha incrementado especialmente en pa..
  38. Delitala A, Pes G, Fanciulli G, Maioli M, Secchi G, Sanciu F, et al. Organ-specific antibodies in LADA patients for the prediction of insulin dependence. Endocr Res. 2016;41:207-12 pubmed publisher
    ..TPOAb), anti-zinc transporter 8 (ZnT8Ab), anti-nuclear (ANA), anti-parietal cell (APCA), anti-smooth muscle (ASMA), anti-mitochondrial (AMA), anti-liver kidney microsomes (LKM), and anti-reticulin (ARA) circulating antibodies ..
  39. Baker L, Ellena J, Handing K, Derewenda U, Utepbergenov D, Engel D, et al. Molecular architecture of the nucleoprotein C-terminal domain from the Ebola and Marburg viruses. Acta Crystallogr D Struct Biol. 2016;72:49-58 pubmed publisher
    ..2014), Acta Cryst. D70, 2420-2429]...
  40. Ak K, Ak E, Dericioglu O, Canak T, Akbuga J, Ozkan N, et al. Tacrolimus-Eluting Suture Inhibits Neointimal Hyperplasia: An Experimental In Vivo Study in Rats. Eur J Vasc Endovasc Surg. 2017;53:431-437 pubmed publisher
    ..histologically by ratio of intimal area (including neointima) and immunohistochemically by ?-smooth muscle actin (ASMA) and proliferating cell nuclear antigen (PCNA) immunostaining...
  41. XU X, Okamoto K. The Nem1-Spo7 protein phosphatase complex is required for efficient mitophagy in yeast. Biochem Biophys Res Commun. 2018;496:51-57 pubmed publisher
    ..We show here that mitophagy is strongly suppressed in yeast cells lacking Nem1 or Spo7, two proteins forming a heterodimeric protein phosphatase complex known to be important for proper shaping ..
  42. Mendonça M, dos Reis R, Freitas A, Sousa A, Pereira A, Faria P, et al. Gene-gene interaction affects coronary artery disease risk. Rev Port Cardiol. 2009;28:397-415 pubmed
    ..This study may contribute to a better understanding of overall genetic risk for CAD rather than that associated with each polymorphism in isolation. ..
  43. Ganesh K, Adam S, Taylor B, Simpson P, Rada C, Neuberger M. CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31. J Biol Chem. 2011;286:17091-102 pubmed publisher
    ..Thus, CTNNBL1 is a novel NLS-binding protein, distinct from karyopherin ?s, with the results suggesting a possible role in the selective intranuclear targeting or interactions of some splicing-associated complexes. ..
  44. Barbosa A, Cerqueira A, Rusak L, dos Reis C, Leal N, Hofer E, et al. Characterization of epidemic clones of Listeria monocytogenes serotype 4b isolated from humans and meat products in Brazil. J Infect Dev Ctries. 2015;9:962-9 pubmed publisher
    ..The presence of ECs (I and II) markers and virulence genes (inlA, inlB, ilnC, inlJ and actA) were evaluated by PCR assay...
  45. Pietropaolo A, Pierri C, Palmieri F, Klingenberg M. The switching mechanism of the mitochondrial ADP/ATP carrier explored by free-energy landscapes. Biochim Biophys Acta. 2016;1857:772-81 pubmed publisher
    ..Klingenberg, Biochim. Biophys. Acta 1778 (2008) 1978-2021)...
  46. Pavić T, Gornik O. Analysis of N-Glycosylation of Total Membrane Proteins. Methods Mol Biol. 2017;1503:197-205 pubmed
    ..Biochim Biophys Acta 1820:1318-1326, 2012)...
  47. Melleby A, Strand M, Romaine A, Herum K, Skrbic B, Dahl C, et al. The Heparan Sulfate Proteoglycan Glypican-6 Is Upregulated in the Failing Heart, and Regulates Cardiomyocyte Growth through ERK1/2 Signaling. PLoS ONE. 2016;11:e0165079 pubmed publisher
    ..In conclusion, our data suggests that glypican-6 plays a role in clinical and experimental heart failure progression by regulating cardiomyocyte growth through ERK signaling. ..
  48. Forsyth C, Francis C. Crystal structures of two 2,3-di-ethyl-naphtho-[2,3-g]quinoxaline-6,11-dione derivatives. Acta Crystallogr E Crystallogr Commun. 2017;73:1125-1129 pubmed publisher
    ..Electron density associated with additional solvent mol-ecules disordered about a fourfold axis was accounted for using the SQUEEZE procedure in PLATON [Spek (2015 ?). Acta Cryst. C71, 9-18].
  49. Aztatzi Aguilar O, Uribe Ramírez M, Arias Montaño J, Barbier O, De Vizcaya Ruiz A. Acute and subchronic exposure to air particulate matter induces expression of angiotensin and bradykinin-related genes in the lungs and heart: Angiotensin-II type-I receptor as a molecular target of particulate matter exposure. Part Fibre Toxicol. 2015;12:17 pubmed publisher
    ..Moreover, exposure to all PM fractions increased coronary artery wall thickness. We demonstrate that exposure to PM induces the expression of RAAS and KKS elements, including AT1R, which was the main target in the lungs and the heart. ..
  50. Jobim Benedetti F, Lúcia Bosa V, Mariante Giesta J, Bueno Fischer G. ANTHROPOMETRIC INDICATORS OF GENERAL AND CENTRAL OBESITY IN THE PREDICTION OF ASTHMA IN ADOLESCENTS; CENTRAL OBESITY IN ASTHMA. Nutr Hosp. 2015;32:2540-8 pubmed publisher
    ..Thus, additional BMI measurements are suggested for asthmatics. Objetivo: determinar la prevalencia de riesgo de asma asociado con indicadores antropométricos de exceso de peso y la distribución de la grasa corporal...
  51. Chan C, Fan J, Messer A, Marston S, Iwamoto H, Ochala J. Myopathy-inducing mutation H40Y in ACTA1 hampers actin filament structure and function. Biochim Biophys Acta. 2016;1862:1453-8 pubmed publisher
    ..broad range of biophysical assays to determine how the lethal and myopathy-related H40Y amino acid substitution in actin affects the structure, stability, and function of this protein...
  52. Elkabbany Z, Elbarbary N, Ismail E, Mohamed N, Ragab D, Abdel Alem S, et al. Transient elastography as a noninvasive assessment tool for hepatopathies of different etiology in pediatric type 1 diabetes mellitus. J Diabetes Complications. 2017;31:186-194 pubmed publisher
    ..HCV), serum immunoglobulins, autoimmune antibodies; anti-nuclear antibody (ANA), anti-smooth muscle antibody (ASMA), and anti-liver kidney microsomal antibody (anti-LKM)...
  53. Schutt C, Myslik J, Rozycki M, Goonesekere N, Lindberg U. The structure of crystalline profilin-beta-actin. Nature. 1993;365:810-6 pubmed
    The three-dimensional structure of bovine profilin-beta-actin has been solved to 2.55 A resolution by X-ray crystallography...
  54. Berg J, Derfler B, Pennisi C, Corey D, Cheney R. Myosin-X, a novel myosin with pleckstrin homology domains, associates with regions of dynamic actin. J Cell Sci. 2000;113 Pt 19:3439-51 pubmed
    ..myosin-X in cultured cells is present at the edges of lamellipodia, membrane ruffles, and the tips of filopodial actin bundles...
  55. Puig Junoy J, Rodríguez Feijóo S, Gonzalez Lopez Valcarcel B, Gómez Navarro V. [Impact of the Pharmaceutical Copayment Reform on the Use of Antidiabetics, Antithrombotics and for Chronic Obstructive Airway Disease Agents, Spain]. Rev Esp Salud Publica. 2016;90:E6 pubmed
    ..a los 38 meses; -3,7% para antitrombóticos a los 6 meses y -4,6% a los 38 meses; -2,7% a los 6 meses para anti-asma y EPOC y -1,3% a los 38 meses...
  56. Haidar Ahmad N, Kissoyan K, Fadlallah S, El Hajj R, Saleh M, Ghosn N, et al. Genotypic and virulence characteristics of Listeria monocytogenes recovered from food items in Lebanon. J Infect Dev Ctries. 2016;10:712-7 pubmed publisher
    ..PCR amplification was performed for three main virulence genes; hly, actA, and inlB. Pulsed field gel electrophoresis (PFGE) and BIONUMERICS analysis were carried out...
  57. Pellegrini L, Parrilli G, Santonicola A, Cinquanta L, Caputo C, Ciacci C, et al. Lack of Clinical Relevance of ANA and ASMA Positivity in Patients with Liver Transplantation without a History of Autoimmune Diseases. Biomed Res Int. 2017;2017:2456916 pubmed publisher
    ..Patients were invited to provide samples to evaluate ANA, AMA, ASMA, and LKM at the time of enrolment (T0), after 6 months (T6), and after 12 months (T12)...
  58. Papp G, Rossi C, Janocha R, Sorez C, Lopez Marrero M, Astruc A, et al. Towards a compact and precise sample holder for macromolecular crystallography. Acta Crystallogr D Struct Biol. 2017;73:829-840 pubmed publisher
    ..A companion paper describes a new sample changer FlexED8 (Papp et al., 2017, Acta Cryst., D73, 841-851).
  59. Prekeris R, Mayhew M, Cooper J, Terrian D. Identification and localization of an actin-binding motif that is unique to the epsilon isoform of protein kinase C and participates in the regulation of synaptic function. J Cell Biol. 1996;132:77-90 pubmed
    ..In this study, we show that an isoform specific interaction between PKC epsilon and filamentous actin may serve as a necessary prelude to the enhancement of glutamate exocytosis from nerve terminals...
  60. Post P, Bokoch G, Mooseker M. Human myosin-IXb is a mechanochemically active motor and a GAP for rho. J Cell Sci. 1998;111 ( Pt 7):941-50 pubmed
    ..In this report we have examined the light chain content, actin binding properties, in vitro motility and rho-GTPase activity of human myosin-IXb purified from leukocytes...
  61. Baatout S, Chatelain B, Staquet P, Symann M, Chatelain C. Interaction between protein kinase C and actin in megakaryocyte polyploidization. Anticancer Res. 1999;19:4193-8 pubmed
    ..In order to study the possible concomitant role of protein kinase C and actin in megakaryocyte polyploidization, three cell lines (DAMI, HEL and K562), expressing some properties of the ..
  62. Koka S, Neudauer C, Li X, Lewis R, McCarthy J, Westendorf J. The formin-homology-domain-containing protein FHOD1 enhances cell migration. J Cell Sci. 2003;116:1745-55 pubmed
    Formin-homology-domain-containing proteins interact with Rho-family GTPases and regulate actin cytoskeleton organization and gene transcription...
  63. Putra O, Umeda D, Fukuzawa K, Gunji M, Yonemochi E. A new solvate of epalerstat, a drug for diabetic neuropathy. Acta Crystallogr E Crystallogr Commun. 2017;73:1264-1267 pubmed publisher
    ..Epalerstat acetone monosolvate was found to be isotypic with epalerstat tertra-hydro-furan solvate [Umeda et al. (2017 ?). Acta Cryst. E73, 941-944].
  64. Anderson K, Hamilton W, Roske F, Azad A, Knudsen T, Canham M, et al. Insulin fine-tunes self-renewal pathways governing naive pluripotency and extra-embryonic endoderm. Nat Cell Biol. 2017;19:1164-1177 pubmed publisher
    Signalling downstream of Activin/Nodal (ActA) and Wnt can induce endoderm differentiation and also support self-renewal in pluripotent cells. Here we find that these apparently contradictory activities are fine-tuned by insulin...
  65. Assunção J, Malavolta E, Domingues V, Gracitelli M, Ferreira Neto A. Outcome assessment in the treatment of rotator cuff tear: what is utilized in Brazil?. Rev Bras Ortop. 2017;52:561-568 pubmed publisher
    ..A literature review was performed using the journals Revista Brasileira de Ortopedia and Acta Ortopédica Brasileira...
  66. Provost P, Doucet J, Hammarberg T, Gerisch G, Samuelsson B, Radmark O. 5-Lipoxygenase interacts with coactosin-like protein. J Biol Chem. 2001;276:16520-7 pubmed
    ..In view of the ability of CLP to bind 5LO and filamentous actin (F-actin), we determined whether CLP could physically link 5LO to actin filaments. However, no F-actin-CLP...
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    Our aim was to examine cell transition events by detecting the frequency of intrapithelial ?-smooth muscle actin (SMA)(+)/cytokeratin (CK)(+) cells during colorectal adenoma-carcinoma sequence, in relation to E-cadherin expression...
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