Genomes and Genes
Gene Symbol: ACTG2
Description: actin, gamma 2, smooth muscle, enteric
Alias: ACT, ACTA3, ACTE, ACTL3, ACTSG, VSCM, actin, gamma-enteric smooth muscle, actin-like protein, alpha-actin-3
- Rey O, Canon J, Krogstad P. HIV-1 Gag protein associates with F-actin present in microfilaments. Virology. 1996;220:530-4 pubmed..In vivo and in vitro analyses of this interaction indicated that the unprocessed Gag polyprotein is capable of association with polymerized actin (F-actin). Binding of Gag to F-actin may be involved in the assembly or budding of HIV-1. ..
- Yoder A, Yu D, Dong L, Iyer S, Xu X, Kelly J, et al. HIV envelope-CXCR4 signaling activates cofilin to overcome cortical actin restriction in resting CD4 T cells. Cell. 2008;134:782-92 pubmed publisher..Conversely, induction of active cofilin greatly facilitates it. These findings shed light on viral exploitation of cellular machinery in resting T cells, where chemokine receptor signaling becomes obligatory. ..
- Gladnikoff M, Shimoni E, Gov N, Rousso I. Retroviral assembly and budding occur through an actin-driven mechanism. Biophys J. 2009;97:2419-28 pubmed publisher..The results of this study show that retroviruses utilize the cell cytoskeleton to expedite their assembly and budding. ..
- Ott D, Coren L, Kane B, Busch L, Johnson D, Sowder R, et al. Cytoskeletal proteins inside human immunodeficiency virus type 1 virions. J Virol. 1996;70:7734-43 pubmed..The presence of these fragments, as well as the incorporation of a few specific cytoskeletal proteins into virions, suggests an active interaction between cytoskeletal and viral proteins. ..
- Wilk T, Gowen B, Fuller S. Actin associates with the nucleocapsid domain of the human immunodeficiency virus Gag polyprotein. J Virol. 1999;73:1931-40 pubmed..The same result was obtained when mature HIV-1 particles were disrupted with detergent. Taken together, these results indicate that actin molecules are associated with the NC domain of the viral polyprotein. ..
- Jolly C, Mitar I, Sattentau Q. Requirement for an intact T-cell actin and tubulin cytoskeleton for efficient assembly and spread of human immunodeficiency virus type 1. J Virol. 2007;81:5547-60 pubmed..Based on these data, we propose that HIV-1 requires both actin and tubulin components of the T-cell cytoskeleton to direct its assembly and budding and to elaborate a functional VS. ..
- Davalieva K, Kiprijanovska S, Maleva Kostovska I, Stavridis S, Stankov O, Komina S, et al. Comparative Proteomics Analysis of Urine Reveals Down-Regulation of Acute Phase Response Signaling and LXR/RXR Activation Pathways in Prostate Cancer. Proteomes. 2017;6: pubmed publisher..proteins with highly confirmed involvement in PCa, while 9 (AZU1, IGHG1, RNASE2, PZP, REG1A, AMY1A, AMY2A, ACTG2, COL18A1) have been associated with different cancers, but not with PCa so far, and may represent novel findings...
- Pedersen J, Pedersen N, Brix S, Grunddal K, Rosenkilde M, Hartmann B, et al. The glucagon-like peptide 2 receptor is expressed in enteric neurons and not in the epithelium of the intestine. Peptides. 2015;67:20-8 pubmed publisher..Our findings provide evidence for the expression of the GLP-2R in intestinal compartments rich in enteric neurons and, importantly they exclude significant expression in the epithelium of rat jejunal mucosa. ..
- Gayathri P, Harne S. Structure and Dynamics of Actin-Like Cytomotive Filaments in Plasmid Segregation. Subcell Biochem. 2017;84:299-321 pubmed publisher..The components that link the filaments to the plasmid DNA also regulate filament dynamics. The modulation of the dynamics facilitates the cytomotive filament to function as a mitotic spindle with a minimal number of components. ..
- The information process may be conceived as an acte of care. Taking into account its' subjective aspects brings into play the notions of "expertise" and "transparency"...
- Jiang X, Wang H, Shen R, Chen G. Engineering the bacterial shapes for enhanced inclusion bodies accumulation. Metab Eng. 2015;29:227-37 pubmed publisher..The molecular mechanism of enlarged bacterial size was found to be directly relate to weakened cytoskeleton which was the result of broken skeleton helix. ..
- Rioux J, Philippe N, Pereira S, Pignol D, Wu L, Ginet N. A second actin-like MamK protein in Magnetospirillum magneticum AMB-1 encoded outside the genomic magnetosome island. PLoS ONE. 2010;5:e9151 pubmed publisher..Thus MamK-like is a new member of the prokaryotic actin-like family. This is the first evidence of a functional mam gene encoded outside the magnetosome genomic island. ..
- Anand A, Zhao H, Nagaraja T, Robinson L, Ganju R. N-terminal Slit2 inhibits HIV-1 replication by regulating the actin cytoskeleton. Retrovirology. 2013;10:2 pubmed publisher..Our study, thus, provides insights into the role of Slit2N in HIV-1 infection and underscores its potential in limiting viral replication in T-cells...
- Defeu Soufo H, Reimold C, Breddermann H, Mannherz H, Graumann P. Translation elongation factor EF-Tu modulates filament formation of actin-like MreB protein in vitro. J Mol Biol. 2015;427:1715-27 pubmed publisher..The data show that MreB can direct the localization of EF-Tu in vivo, which in turn positively affects the formation and dynamics of MreB filaments. Thus, EF-Tu is a modulator of the activity of a bacterial actin-like protein. ..
- Thorson W, Diaz Horta O, Foster J, Spiliopoulos M, Quintero R, Farooq A, et al. De novo ACTG2 mutations cause congenital distended bladder, microcolon, and intestinal hypoperistalsis. Hum Genet. 2014;133:737-42 pubmed publisher..R178L, in the gene encoding the smooth muscle gamma-2 actin, ACTG2. We subsequently detected another de novo ACTG2 mutation, p.R178C, in an additional child with MMIHS...
- Drew J, Farquharson A, Mayer C, Vase H, Coates P, Steele R, et al. Predictive gene signatures: molecular markers distinguishing colon adenomatous polyp and carcinoma. PLoS ONE. 2014;9:e113071 pubmed publisher..differentiation (B4GANLT2, CDX1, CDX2), apoptotic (CASP3, NOX1, NTN1), fibroblast (FSP1, COL1A1), structural (ACTG2, CNN1, DES), gene transcription (HDAC1), stem cell (LGR5), endothelial (VWF) and mucin production (MUC2)...
- Refojo P, Calisto F, Ribeiro M, Teixeira M, Pereira M. The monoheme cytochrome c subunit of Alternative Complex III is a direct electron donor to caa3 oxygen reductase in Rhodothermus marinus. Biol Chem. 2017;398:1037-1044 pubmed publisher..In this work we further explored ACIII investigating the role of its monoheme cytochrome c subunit (ActE)...
- Benzoubir N, Mussini C, Lejamtel C, Dos Santos A, Guillaume C, Desterke C, et al. Gamma-smooth muscle actin expression is associated with epithelial-mesenchymal transition and stem-like properties in hepatocellular carcinoma. PLoS ONE. 2015;10:e0130559 pubmed publisher..This correlation suggests that Î³SMA represents a novel and powerful marker to predict HCC progression. ..
- Moreno C, Sobreira N, Pugh E, Zhang P, Steel G, Torres F, et al. Homozygous deletion in MYL9 expands the molecular basis of megacystis-microcolon-intestinal hypoperistalsis syndrome. Eur J Hum Genet. 2018;26:669-675 pubmed publisher..The molecular basis of this condition started to be defined recently, and the genes related to the syndrome (ACTG2-heterozygous variant in sporadic cases; and MYH11 (myosin heavy chain 11), LMOD1 (leiomodin 1) and MYLK (myosin ..
- Hearps A, Jans D. Regulating the functions of the HIV-1 matrix protein. AIDS Res Hum Retroviruses. 2007;23:341-6 pubmed..J Virol 2005;79:13028-13036) confirms the importance of this protein for HIV infection and highlights a potentially new avenue in multivalent drug therapy. ..
- Lu W, Xiao Y, Huang J, Tao Y, Yan W, Lu L, et al. Mutation in Actin Î³-2 Responsible for Megacystis Microcolon Intestinal Hypoperistalsis Syndrome in 4 Chinese Patients. J Pediatr Gastroenterol Nutr. 2016;63:624-626 pubmed..Our report suggested that R257 variant in the ACTG2 appear to be more frequent in populations of Asian ancestry; mutation of this locus could cause alterations of the ..
- Peyron P, David M. [Suicide risk assessment tools for adults in general medical practice]. Presse Med. 2015;44:590-600 pubmed publisher..The Grille d'estimation de la dangerositÃ© d'un passage Ã l'acte suicidaire is the only interview to have been validated in primary care so far...
- Moreno C, Metze K, Lomazi E, Bertola D, Barbosa R, Cosentino V, et al. Visceral myopathy: Clinical and molecular survey of a cohort of seven new patients and state of the art of overlapping phenotypes. Am J Med Genet A. 2016;170:2965-2974 pubmed publisher..genetic bases of these conditions recently begun to be clarified with the identification of pathogenic variants in ACTG2, ACTA2, and MYH11 in individuals with visceral motility dysfunction...
- Lu W, Fang L, Ouyang B, Zhang X, Zhan S, Feng X, et al. Actl6a protects embryonic stem cells from differentiating into primitive endoderm. Stem Cells. 2015;33:1782-93 pubmed publisher..Our findings uncover a novel function of Actl6a in mESCs, where it acts as a gatekeeper to prevent mESCs from entering into the PrE lineage through a Yin/Yang regulating pattern. ..
- Radke I, GÃ¶tte M, Smollich M, Scharle N, Kiesel L, WÃ¼lfing P. Expression of PRL-3 regulates proliferation and invasion of breast cancer cells in vitro. Arch Gynecol Obstet. 2017;296:1153-1160 pubmed publisher..Loss of PRL-3 function induces an antimetastatic gene expression profile in breast cancer cells. Due to its role in tumor growth and metastasis, PRL-3 emerges as a new therapeutic target in breast cancer therapy. ..
- Ueyama H. A HindIII DNA polymorphism in the human enteric type smooth muscle actin gene (ACTSG). Nucleic Acids Res. 1991;19:411 pubmed
- Halim D, Brosens E, Muller F, Wangler M, Beaudet A, Lupski J, et al. Loss-of-Function Variants in MYLK Cause Recessive Megacystis Microcolon Intestinal Hypoperistalsis Syndrome. Am J Hum Genet. 2017;101:123-129 pubmed publisher..To date, three genes are known to be involved in MMIHS pathogenesis: ACTG2, MYH11, and LMOD1...
- Zaretsky D, Zaretskaia M, DiMicco J. Characterization of the relationship between spontaneous locomotor activity and cardiovascular parameters in conscious freely moving rats. Physiol Behav. 2016;154:60-7 pubmed publisher..Act and HR could be approximated by the negative exponential function HR(Act)=HRmax-(HRmax-HRmin)âˆ—exp(-Act/Acte), where HRmax, HRmin, and Acte are constants...
- Mura A, Fadda D, Perez A, Danforth M, Musu D, Rico A, et al. Roles of the Essential Protein FtsA in Cell Growth and Division in Streptococcus pneumoniae. J Bacteriol. 2017;199: pubmed publisher..Here, we focus on the properties of the actin-like protein FtsA as an essential orchestrator of peripheral and septal growth in this bacterium. ..
- Klar J, Raykova D, Gustafson E, TÃ³thovÃ¡ I, Ameur A, Wanders A, et al. Phenotypic expansion of visceral myopathy associated with ACTG2 tandem base substitution. Eur J Hum Genet. 2015;23:1679-83 pubmed publisher..806_807delinsAA (p.(Gly269Glu)) in ACTG2, encoding smooth muscle actin Î³-2, in affected family members...
- Matera I, Rusmini M, Guo Y, Lerone M, Li J, Zhang J, et al. Variants of the ACTG2 gene correlate with degree of severity and presence of megacystis in chronic intestinal pseudo-obstruction. Eur J Hum Genet. 2016;24:1211-5 pubmed publisher..After identifying a heterozygous missense variant in the ACTG2 gene in one of 10 patients undergone WES, targeted Sanger sequencing of this gene allowed to detect heterozygous ..
- Jiang S, Narita A, Popp D, Ghoshdastider U, Lee L, Srinivasan R, et al. Novel actin filaments from Bacillus thuringiensis form nanotubules for plasmid DNA segregation. Proc Natl Acad Sci U S A. 2016;113:E1200-5 pubmed publisher..Thus, in this prokaryote, the actin fold has evolved to produce a filament system with comparable features to the eukaryotic chromosome-segregating microtubule. ..
- Lin G, McCormick J, Johnstone R. Is gamma-actin a regulator of amino acid transport?. Am J Physiol. 1996;270:C1647-55 pubmed..The data suggest that the gamma-actin-like protein coded for by E51 cDNA may play a significant regulatory role in amino acid transport...
- Colavin A, Shi H, Huang K. RodZ modulates geometric localization of the bacterial actin MreB to regulate cell shape. Nat Commun. 2018;9:1280 pubmed publisher..Thus, E. coli canÂ control its shape and dimensions by differentially regulating RodZ and MreB to alter the patterning of cell-wall insertion, highlighting the rich regulatory landscape of cytoskeletal molecular biophysics. ..
- Szucsik J, Lessard J. Cloning and sequence analysis of the mouse smooth muscle gamma-enteric actin gene. Genomics. 1995;28:154-62 pubmed..Putative regulatory elements are noted as well as regions of the gene that have the potential to form non-B DNA conformations that may influence gene expression. ..
- Bathula C, Tripathi S, Srinivasan R, Jha K, Ganguli A, Chakrabarti G, et al. Synthesis of novel 5-arylidenethiazolidinones with apoptotic properties via a three component reaction using piperidine as a bifunctional reagent. Org Biomol Chem. 2016;14:8053-63 pubmed publisher..52 ?M) as an apoptotic agent. A novel chemical proteomics approach identified ?-actin-like protein 2, ?-enolase and macrophage migration inhibitory factor (MMIF) as putative cellular binding partners of 17i. ..
- Lai J, Moya L, An J, Hoffman A, Srinivasan S, Panchadsaram J, et al. A microsatellite repeat in PCA3 long non-coding RNA is associated with prostate cancer risk and aggressiveness. Sci Rep. 2017;7:16862 pubmed publisher..Our analysis indicated that three of these STRs (TAAA-ACTG2, TTTTG-TRIB1, and TG-PCA3) are polymorphic and differentially expressed in prostate tumors compared to adjacent ..
- Wu R, Gu Y, Xu Y, Mitola S, Bussolino F, Terada L. Human immunodeficiency virus type 1 Tat regulates endothelial cell actin cytoskeletal dynamics through PAK1 activation and oxidant production. J Virol. 2004;78:779-89 pubmed..We conclude that Tat induces actin cytoskeletal rearrangements through PAK1 and downstream activation of the endothelial NADPH oxidase. ..
- Denard J, Rundwasser S, Laroudie N, Gonnet F, Naldini L, Radrizzani M, et al. Quantitative proteomic analysis of lentiviral vectors using 2-DE. Proteomics. 2009;9:3666-76 pubmed publisher..This study defines for the first time, the protein stoichiometry of infectious HIV-1-derived LV particles. ..
- Snasel J, Pichova I. The cleavage of host cell proteins by HIV-1 protease. Folia Biol (Praha). 1996;42:227-30 pubmed
- Milunsky A, Baldwin C, Zhang X, Primack D, Curnow A, Milunsky J. Diagnosis of Chronic Intestinal Pseudo-obstruction and Megacystis by Sequencing the ACTG2 Gene. J Pediatr Gastroenterol Nutr. 2017;65:384-387 pubmed publisher..This report aimed to determine the efficacy of sequencing the actin Î³-2 (ACTG2) gene for diagnosis...
- Lattanzi G, Cenni V, Marmiroli S, Capanni C, Mattioli E, Merlini L, et al. Association of emerin with nuclear and cytoplasmic actin is regulated in differentiating myoblasts. Biochem Biophys Res Commun. 2003;303:764-70 pubmed..These data provide evidence of a modulation of emerin-actin interaction in muscle cells, possibly through differentiation-related stimuli. ..
- Webb R. Smooth muscle contraction and relaxation. Adv Physiol Educ. 2003;27:201-6 pubmed..Removal of Ca(2+) from the cytosol and stimulation of myosin phosphatase initiate the process of smooth muscle relaxation...
- Coiras M, Camafeita E, Ureña T, Lopez J, Caballero F, Fernández B, et al. Modifications in the human T cell proteome induced by intracellular HIV-1 Tat protein expression. Proteomics. 2006;6 Suppl 1:S63-73 pubmed..In conclusion, in addition to its role in viral mRNA elongation, the proteomic approach has provided insight into the way that Tat modifies host cell gene expression. ..
- Goldberg M, Han Y, Yan C, Shaw M, Garner W. TNF-alpha suppresses alpha-smooth muscle actin expression in human dermal fibroblasts: an implication for abnormal wound healing. J Invest Dermatol. 2007;127:2645-55 pubmed..Therefore, the balance of cytokines in a wound defines the mechanical properties of the extracellular matrix and optimal wound healing. ..
- Adams L, Tomasselli A, Robbins P, Moss B, Heinrikson R. HIV-1 protease cleaves actin during acute infection of human T-lymphocytes. AIDS Res Hum Retroviruses. 1992;8:291-5 pubmed..Hydrolysis by the HIV-1 protease of physiologically important host cellular proteins during infection may have important consequences relative to viral pathogenesis. ..
- Zhang Y, Cui P, Li Y, Feng G, Tong M, Guo L, et al. Mitochondrially produced ATP affects stem cell pluripotency via Actl6a-mediated histone acetylation. FASEB J. 2017;: pubmed publisher..Zhang, Y., Cui, P., Li, Y., Feng, G., Tong, M., Guo, L., Li, T., Liu, L., Li, W., Zhou, Q. Mitochondrially produced ATP affects stem cell pluripotency via Actl6a-mediated histone acetylation...
- Dordor A, Poudevigne E, Gottlinger H, Weissenhorn W. Essential and supporting host cell factors for HIV-1 budding. Future Microbiol. 2011;6:1159-70 pubmed publisher..Here we review recent advances in understanding the role of host cell factors recruited by Gag during HIV-1 assembly and budding. ..
- Al Soraj M, He L, Peynshaert K, Cousaert J, Vercauteren D, Braeckmans K, et al. siRNA and pharmacological inhibition of endocytic pathways to characterize the differential role of macropinocytosis and the actin cytoskeleton on cellular uptake of dextran and cationic cell penetrating peptides octaarginine (R8) and HIV-Tat. J Control Release. 2012;161:132-41 pubmed publisher
- Edfeldt K, Hellman P, Westin G, Stalberg P. A plausible role for actin gamma smooth muscle 2 (ACTG2) in small intestinal neuroendocrine tumorigenesis. BMC Endocr Disord. 2016;16:19 pubmed publisher..Low mRNA expression levels of actin gamma smooth muscle 2 (ACTG2) have been demonstrated in metastases relative to primary SI-NETs...
- Chandrasekaran P, Buckley M, Moore V, Wang L, Kehrl J, Venkatesan S. HIV-1 Nef impairs heterotrimeric G-protein signaling by targeting G?(i2) for degradation through ubiquitination. J Biol Chem. 2012;287:41481-98 pubmed publisher..By specifically degrading G?(i2), Nef directly subverts leukocyte migration and homing. Impaired trafficking and homing of HIV Nef-expressing lymphocytes probably contributes to early immune dysfunction following HIV infection. ..
- Wangler M, Gonzaga Jauregui C, Gambin T, Penney S, Moss T, Chopra A, et al. Heterozygous de novo and inherited mutations in the smooth muscle actin (ACTG2) gene underlie megacystis-microcolon-intestinal hypoperistalsis syndrome. PLoS Genet. 2014;10:e1004258 pubmed publisher..We identified heterozygous ACTG2 missense variants in 15 unrelated subjects, ten being apparent de novo mutations...
- Ueyama H, Inazawa J, Nishino H, Han Xiang D, Ochiai Y, Ohkubo I. Chromosomal mapping of the human smooth muscle actin gene (enteric type, ACTA3) to 2p13.1 and molecular nature of the hindIII polymorphism. Genomics. 1995;25:720-3 pubmedThe human gene for smooth muscle actin (enteric type, ACTA3) has been isolated, and three overlapping clones, lambda HACTSG-17, -2, and -112, were used as probes for fluorescence in situ hybridization of human chromosomes...
- Brainard A, Miller A, Martens J, England S. Maxi-K channels localize to caveolae in human myometrium: a role for an actin-channel-caveolin complex in the regulation of myometrial smooth muscle K+ current. Am J Physiol Cell Physiol. 2005;289:C49-57 pubmed..These data indicate that the actin cytoskeleton is involved as part of a caveolar complex in the regulation of myometrial maxi-K channel function. ..
- Filmore R, Dean D, Zimmer W. The smooth muscle gamma-actin gene is androgen responsive in prostate epithelia. Gene Expr. 2002;10:201-11 pubmed..Thus, SMGA gene activity in prostate epithelia is due, in part, to the androgen-dependent expression of Nkx 3.1. As such, our studies provide the initial description of Nkx 3.1 target gene regulatory activity in the prostate. ..
- Cheng C, Sharp P. RNA polymerase II accumulation in the promoter-proximal region of the dihydrofolate reductase and gamma-actin genes. Mol Cell Biol. 2003;23:1961-7 pubmed..These results suggest that the accumulation of paused Pol II in promoter-proximal regions may be a common feature of gene regulation in mammalian cells. ..
- Miwa T, Kamada S. The nucleotide sequence of a human smooth muscle (enteric type) gamma-actin cDNA. Nucleic Acids Res. 1990;18:4263 pubmed
- Chang K, Yang P, Lai H, Yeh T, Chen T, Yeh C. Identification of a novel actin isoform in hepatocellular carcinoma. Hepatol Res. 2006;36:33-9 pubmed..A novel class of actin isoforms was expressed in some hepatocellular carcinoma tissues, replacing beta-actins to become the major constituents of actin cytoskeleton. ..
- Ishaq M, Lin B, Bosche M, Zheng X, Yang J, Huang D, et al. LIM kinase 1 - dependent cofilin 1 pathway and actin dynamics mediate nuclear retinoid receptor function in T lymphocytes. BMC Mol Biol. 2011;12:41 pubmed publisher..We suggest that T cell activation-induced repression of nuclear receptor-dependent transactivation is in part through the modification of actin dynamics. ..
- Laasanen J, Helisalmi S, Iivonen S, Eloranta M, Hiltunen M, Heinonen S. Gamma 2 actin gene (enteric type) polymorphism is not associated with obstetric cholestasis or preeclampsia. Fetal Diagn Ther. 2008;23:36-40 pubmed..680) groups compared to the control group. This insertion-deletion polymorphism in the intron 1 of the gamma 2 actin gene is unlikely to play any significant role in obstetric cholestasis or preeclampsia in patients from eastern Finland. ..
- Zhang H, Wang L, Kao S, Whitehead I, Hart M, Liu B, et al. Functional interaction between the cytoplasmic leucine-zipper domain of HIV-1 gp41 and p115-RhoGEF. Curr Biol. 1999;9:1271-4 pubmed..These findings suggest that an important function of gp41C is to modulate the activity of p115-RhoGEF and they thus reveal a new potential anti-HIV-1 target. ..
- Schiralli Lester G, Akiyama H, Evans E, Singh J, Gummuluru S, Henderson A. Interleukin 2-inducible T cell kinase (ITK) facilitates efficient egress of HIV-1 by coordinating Gag distribution and actin organization. Virology. 2013;436:235-43 pubmed publisher..These data provide insight as to how ITK influences HIV-1 replication and suggest that targeting host factors that regulate HIV-1 egress provides an innovative strategy for controlling HIV infection. ..
- Kerviel A, Thomas A, Chaloin L, Favard C, Muriaux D. Virus assembly and plasma membrane domains: which came first?. Virus Res. 2013;171:332-40 pubmed publisher..This mechanism involves the trapping of acidic lipids by the viral Gag protein by means of ionic protein-lipid interactions, inducing thereby formation of acidic lipid-enriched microdomains (ALEM). ..
- Miwa T, Manabe Y, Kurokawa K, Kamada S, Kanda N, Bruns G, et al. Structure, chromosome location, and expression of the human smooth muscle (enteric type) gamma-actin gene: evolution of six human actin genes. Mol Cell Biol. 1991;11:3296-306 pubmed..Subsequently, striated muscle actin and smooth muscle actin genes may have evolved from this prototype by loss of an intron at site 4 and acquisition of a new intron at site 3, respectively. ..
- Bertrand S, Mactutus C, Aksenova M, Espensen Sturges T, Booze R. Synaptodendritic recovery following HIV Tat exposure: neurorestoration by phytoestrogens. J Neurochem. 2014;128:140-51 pubmed publisher..This neurorestoration was mediated by estrogen receptors (ER). These results suggest that plant-derived phytoestrogens may promote recovery from HIV-1-induced synaptodendritic damage...
- Tuzović L, Tang S, Miller R, Rohena L, Shahmirzadi L, Gonzalez K, et al. New Insights into the Genetics of Fetal Megacystis: ACTG2 Mutations, Encoding Î³-2 Smooth Muscle Actin in Megacystis Microcolon Intestinal Hypoperistalsis Syndrome (Berdon Syndrome). Fetal Diagn Ther. 2015;38:296-306 pubmed publisher..Whole-exome sequencing (WES) and Sanger sequencing of the ACTG2 gene. We identified a novel heterozygous de novo missense variant in ACTG2 c.770G>A (p...
- Stoddard P, Williams T, Garner E, Baum B. Evolution of polymer formation within the actin superfamily. Mol Biol Cell. 2017;28:2461-2469 pubmed publisher..Thus all the known actin-like polymers are likely to be the descendants of a single, ancestral, polymer-forming actin-like protein. ..
- Bertrand S, Aksenova M, Mactutus C, Booze R. HIV-1 Tat protein variants: critical role for the cysteine region in synaptodendritic injury. Exp Neurol. 2013;248:228-35 pubmed publisher..Preventing such early synaptic loss may attenuate HIV-1 associated neurocognitive disorders. ..
- Wu Y, Liu Z, Shi M, Yu H, Jiang X, Yang A, et al. Identification of ACTG2 functions as a promoter gene in hepatocellular carcinoma cells migration and tumor metastasis. Biochem Biophys Res Commun. 2017;491:537-544 pubmed publisher..Here, we describes actin gamma smooth muscle 2 (ACTG2) over-express in HCC and demonstrates high-expression of ACTG2 as a promising therapeutic target in HCC metastasis...
- Halim D, Hofstra R, Signorile L, Verdijk R, Van Der Werf C, Sribudiani Y, et al. ACTG2 variants impair actin polymerization in sporadic Megacystis Microcolon Intestinal Hypoperistalsis Syndrome. Hum Mol Genet. 2016;25:571-83 pubmed publisher..is a rare congenital disorder, in which heterozygous missense variants in the Enteric Smooth Muscle actin Î³-2 (ACTG2) gene have been recently identified...
- Yonemoto S, Machiguchi T, Nomura K, Minakata T, Nanno M, Yoshida H. Correlations of tissue macrophages and cytoskeletal protein expression with renal fibrosis in patients with diabetes mellitus. Clin Exp Nephrol. 2006;10:186-92 pubmed..In addition, it was suggested that peritubular alphaSMA-positive myofibroblastic cells, in collaboration with interstitial macrophages, contribute to the progression of interstitial fibrosis in diabetic nephropathy. ..
- Krogstad P, Geng Y, Rey O, Canon J, Ibarrondo F, Ackerson B, et al. Human immunodeficiency virus nucleocapsid protein polymorphisms modulate the infectivity of RNA packaging mutants. Virology. 2002;294:282-8 pubmed..Conservative amino acid differences between HXB2 and NL4-3 NCs were sufficient to explain the difference in infectivity of viruses carrying the R10A and K11A mutations. ..
- Marttila M, Hanif M, Lemola E, Nowak K, Laitila J, GrÃ¶nholm M, et al. Nebulin interactions with actin and tropomyosin are altered by disease-causing mutations. Skelet Muscle. 2014;4:15 pubmed publisher..We demonstrate for the first time the existence of direct tropomyosin-nebulin interactions in vitro, and show that nebulin interactions with actin and tropomyosin are altered by disease-causing mutations in nebulin and tropomyosin. ..
- Sun Q, Taurin S, Sethakorn N, Long X, Imamura M, Wang D, et al. Myocardin-dependent activation of the CArG box-rich smooth muscle gamma-actin gene: preferential utilization of a single CArG element through functional association with the NKX3.1 homeodomain protein. J Biol Chem. 2009;284:32582-90 pubmed publisher..Here we report that the human ACTG2 promoter, containing four conserved CArG elements, displays SMC-specific basal activity and is highly induced in ..
- Tomasselli A, Hui J, Adams L, Chosay J, Lowery D, Greenberg B, et al. Actin, troponin C, Alzheimer amyloid precursor protein and pro-interleukin 1 beta as substrates of the protease from human immunodeficiency virus. J Biol Chem. 1991;266:14548-53 pubmed
- Qian Y, Han Q, Liu D, Tu P, Zeng K, Liang H. [Anti-tumor target identification and molecular mechanism study of total saponins from Albizia julibrissin]. Zhongguo Zhong Yao Za Zhi. 2017;42:3661-3665 pubmed publisher..In summary, our findings elucidate the potential anti-tumor mechanism of TSAJ from the direct target proteins, and provide a new insight for exploring the pharmacological mechanism of traditional Chinese medicine...
- Perrin Tricaud C, Davoust J, Jones I. Tagging the human immunodeficiency virus gag protein with green fluorescent protein. Minimal evidence for colocalisation with actin. Virology. 1999;255:20-5 pubmed..These data suggest that Gag may associate with other cytoskeletal components or, perhaps more likely, that a partial assembly to a large-molecular-weight intermediate occurs before localisation at the plasma membrane. ..
- Lyonnais S, Gorelick R, Heniche Boukhalfa F, Bouaziz S, Parissi V, Mouscadet J, et al. A protein ballet around the viral genome orchestrated by HIV-1 reverse transcriptase leads to an architectural switch: from nucleocapsid-condensed RNA to Vpr-bridged DNA. Virus Res. 2013;171:287-303 pubmed publisher
- Kohnen G, Campbell S, Jeffers M, Cameron I. Spatially regulated differentiation of endometrial vascular smooth muscle cells. Hum Reprod. 2000;15:284-92 pubmed..Endometrial VSMC differentiation involves a progressive increase in cytoskeletal complexity and occurs in a spatially regulated fashion. ..