acetylcholinesterase

Summary

Gene Symbol: acetylcholinesterase
Description: acetylcholinesterase (Cartwright blood group)
Alias: ACEE, ARACHE, N-ACHE, acetylcholinesterase, Yt blood group, acetylcholinesterase (Yt blood group), apoptosis-related acetylcholinesterase
Species: human
Products:     acetylcholinesterase

Top Publications

  1. Soreq H, Seidman S. Acetylcholinesterase--new roles for an old actor. Nat Rev Neurosci. 2001;2:294-302 pubmed
    ..of the first neurotransmitter--acetylcholine--was soon followed by the discovery of its hydrolysing enzyme, acetylcholinesterase. The role of acetylcholinesterase in terminating acetylcholine-mediated neurotransmission made it the focus ..
  2. Velan B, Kronman C, Ordentlich A, Flashner Y, Leitner M, Cohen S, et al. N-glycosylation of human acetylcholinesterase: effects on activity, stability and biosynthesis. Biochem J. 1993;296 ( Pt 3):649-56 pubmed
    The role of N-glycosylation in the function of human acetylcholinesterase (HuAChE) was examined by site-directed mutagenesis (Asn to Gln substitution) of the three potential N-glycosylation sites Asn-265, Asn-350 and Asn-464...
  3. Getman D, Eubanks J, Camp S, Evans G, Taylor P. The human gene encoding acetylcholinesterase is located on the long arm of chromosome 7. Am J Hum Genet. 1992;51:170-7 pubmed
    b>Acetylcholinesterase (AChE) is a secreted enzyme essential for regulating cholinergic neurotransmission at neuronal and neuromuscular synapses...
  4. Velan B, Grosfeld H, Kronman C, Leitner M, Gozes Y, Lazar A, et al. The effect of elimination of intersubunit disulfide bonds on the activity, assembly, and secretion of recombinant human acetylcholinesterase. Expression of acetylcholinesterase Cys-580----Ala mutant. J Biol Chem. 1991;266:23977-84 pubmed
    Site-directed mutagenesis was used to study the cysteine residue involved in the assembly of human acetylcholinesterase (HuAChE) catalytic subunits...
  5. Meshorer E, Erb C, Gazit R, Pavlovsky L, Kaufer D, Friedman A, et al. Alternative splicing and neuritic mRNA translocation under long-term neuronal hypersensitivity. Science. 2002;295:508-12 pubmed
    ..long-term consequences of stress, we studied stress-induced changes in the neuritic translocation of acetylcholinesterase (AChE) splice variants. Under normal conditions, we found the synaptic AChE-S mRNA and protein in neurites...
  6. Perrier A, Massoulié J, Krejci E. PRiMA: the membrane anchor of acetylcholinesterase in the brain. Neuron. 2002;33:275-85 pubmed
    As a tetramer, acetylcholinesterase (AChE) is anchored to the basal lamina of the neuromuscular junction and to the membrane of neuronal synapses. We have previously shown that collagen Q (ColQ) anchors AChE at the neuromuscular junction...
  7. Meshorer E, Soreq H. Virtues and woes of AChE alternative splicing in stress-related neuropathologies. Trends Neurosci. 2006;29:216-24 pubmed
    The ACh hydrolyzing enzyme acetylcholinesterase (AChE) is a combinatorial series of proteins with variant N and C termini generated from alternate promoter usage and 3' alternative splicing...
  8. Eggers C, Herholz K, Kalbe E, Heiss W. Cortical acetylcholine esterase activity and ApoE4-genotype in Alzheimer disease. Neurosci Lett. 2006;408:46-50 pubmed
    ..05) in the ApoE4 negative group only. These results indicate that cortical AChE activity is relatively well preserved in ApoE4 carriers, either by preservation of its cellular expression or as AChE activity in amyloid plaques. ..
  9. Toiber D, Berson A, Greenberg D, Melamed Book N, Diamant S, Soreq H. N-acetylcholinesterase-induced apoptosis in Alzheimer's disease. PLoS ONE. 2008;3:e3108 pubmed publisher
    ..Here, we report that overexpression of an N-terminally extended "synaptic" acetylcholinesterase variant, N-AChE-S is causally involved in both these phenomena...

More Information

Publications122 found, 100 shown here

  1. Sklan E, Lowenthal A, Korner M, Ritov Y, Landers D, Rankinen T, et al. Acetylcholinesterase/paraoxonase genotype and expression predict anxiety scores in Health, Risk Factors, Exercise Training, and Genetics study. Proc Natl Acad Sci U S A. 2004;101:5512-7 pubmed
    ..interrelationships between expression variations and nucleotide polymorphisms of the chromosome 7q21-22 acetylcholinesterase-paraoxonase 1 (ACHE-PON1) locus with the trait- and state-anxiety measures of 461 healthy subjects from the ..
  2. Paraoanu L, Layer P. Mouse acetylcholinesterase interacts in yeast with the extracellular matrix component laminin-1beta. FEBS Lett. 2004;576:161-4 pubmed
    b>Acetylcholinesterase (AChE) is likely to have roles other than the hydrolysis of acetylcholine, e.g., related to developmental processes like neurite outgrowth, differentiation and adhesion...
  3. Bernardi C, Ribeiro E, Cavalli I, Chautard Freire Maia E, Souza R. Amplification and deletion of the ACHE and BCHE cholinesterase genes in sporadic breast cancer. Cancer Genet Cytogenet. 2010;197:158-65 pubmed publisher
    Increasing evidence supports the involvement of acetylcholinesterase and butyrylcholinesterase in cell proliferation control and differentiation, reinforcing the hypothesis that these enzymes might have an influence in tumorigenesis...
  4. Zhao Y, Wang X, Wang T, Hu X, Hui X, Yan M, et al. Acetylcholinesterase, a key prognostic predictor for hepatocellular carcinoma, suppresses cell growth and induces chemosensitization. Hepatology. 2011;53:493-503 pubmed publisher
    b>Acetylcholinesterase (ACHE) plays important roles in the cholinergic system, and its dysregulation is involved in a variety of human diseases. However, the roles and implications of ACHE in hepatocellular carcinoma (HCC) remain elusive...
  5. Johnson G, Moore S. Human acetylcholinesterase binds to mouse laminin-1 and human collagen IV by an electrostatic mechanism at the peripheral anionic site. Neurosci Lett. 2003;337:37-40 pubmed
    b>Acetylcholinesterase (EC 3.1.1.7; AChE) is known to induce neurite outgrowth and differentiation, but its ligands are as yet unknown. Laminin-1 and collagen IV were investigated as potential ligands for AChE...
  6. Meshorer E, Toiber D, Zurel D, Sahly I, Dori A, Cagnano E, et al. Combinatorial complexity of 5' alternative acetylcholinesterase transcripts and protein products. J Biol Chem. 2004;279:29740-51 pubmed
    ..inter-relationship to alternative splicing, we searched expression sequence tags for the 5' region of acetylcholinesterase (ACHE) genes. Three and five novel first exons were identified in human and mouse ACHE genes, respectively...
  7. Muñoz Delgado E, Montenegro M, Campoy F, Moral Naranjo M, Cabezas Herrera J, Kovacs G, et al. Expression of cholinesterases in human kidney and its variation in renal cell carcinoma types. FEBS J. 2010;277:4519-29 pubmed publisher
    ..In studies with papillary RCC (pRCC), conventional RCC, chromophobe RCC, and renal oncocytoma, acetylcholinesterase activity increased in pRCC (3.92 ± 3.01 mU·mg(-1), P = 0.031) and conventional RCC (2.64 ± 1...
  8. Lu L, Zhang X, Zhang B, Wu J, Zhang X. Synaptic acetylcholinesterase targeted by microRNA-212 functions as a tumor suppressor in non-small cell lung cancer. Int J Biochem Cell Biol. 2013;45:2530-40 pubmed publisher
    b>Acetylcholinesterase expression is modulated in various types of tumor, which suggests it is associated with tumor development; however, the mechanism of acetylcholinesterase gene regulation in tumors remains unclear...
  9. Chik W, Zhu L, Fan L, Yi T, Zhu G, Gou X, et al. Saussurea involucrata: A review of the botany, phytochemistry and ethnopharmacology of a rare traditional herbal medicine. J Ethnopharmacol. 2015;172:44-60 pubmed publisher
    ..The sustainable use of this endangered resource was also addressed. In conclusion, this review was anticipated to highlight the importance of S. involucrata and provides some directions for the future development of this plant. ..
  10. Esmaeilnejad B, Tavassoli M, Samiei A, Hajipour N, Imani Baran A, Farhang Pajuh F. Evaluation of oxidative stress and antioxidant status, serum trace mineral levels and cholinesterases activity in cattle infected with Anaplasma marginale. Microb Pathog. 2018;123:402-409 pubmed publisher
    ..dehydrogenase (G6PD), total antioxidant capacity (TAC), median corpuscularfragility (MCF) as well as acetylcholinesterase (AChE), and serum concentrations of antioxidant trace minerals (copper, iron, zinc, manganese, and selenium)..
  11. Hagstrom D, Hirokawa H, Zhang L, Radic Z, Taylor P, Collins E. Planarian cholinesterase: in vitro characterization of an evolutionarily ancient enzyme to study organophosphorus pesticide toxicity and reactivation. Arch Toxicol. 2017;91:2837-2847 pubmed publisher
    ..nervous system, has shown acylthiocholine catalysis, it is unknown whether this is accomplished through an acetylcholinesterase (AChE), butyrylcholinesterase (BChE), or a hybrid esterase and how OP exposure affects esterase activity...
  12. Ling Y, Qu R, Luo Y. [Clinical analysis of the first patient with imported Middle East respiratory syndrome in China]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2015;27:630-4 pubmed publisher
    ..It is the first case of MERS in China, therefore, the clinical manifestations and the treatment strategy need to be further explored. ..
  13. Wilhelm C, Snider T, Babin M, Jett D, Platoff G, Yeung D. A comprehensive evaluation of the efficacy of leading oxime therapies in guinea pigs exposed to organophosphorus chemical warfare agents or pesticides. Toxicol Appl Pharmacol. 2014;281:254-65 pubmed publisher
    ..is the administration of atropine in combination with an oxime antidote (2-PAM Cl) to reactivate inhibited acetylcholinesterase (AChE). Depending on clinical symptoms, an anticonvulsant, e.g., diazepam, may also be administered...
  14. Omar S, Scott C, Hamlin A, Obied H. Biophenols: Enzymes (?-secretase, Cholinesterases, histone deacetylase and tyrosinase) inhibitors from olive (Olea europaea L.). Fitoterapia. 2018;128:118-129 pubmed publisher
    ..prime amyloid beta (A?) producing enzyme (?-secretase: BACE-1) and disease progression enzymes including acetylcholinesterase (AChE), butyrylcholinesterase (BChE), histone deacetylase (HDAC), and tyrosinase along with the ..
  15. Abdel Salam O, Youness E, Mohammed N, Yassen N, Khadrawy Y, El Toukhy S, et al. Nitric oxide synthase inhibitors protect against brain and liver damage caused by acute malathion intoxication. Asian Pac J Trop Med. 2017;10:773-786 pubmed publisher
    ..Moreover, the activities of glutathione peroxidase (GPx) acetylcholinesterase (AChE), and butyrylcholinesterase (BChE), total antioxidant capacity (TAC), glucose concentrations were ..
  16. Jokanovic M, Prostran M. Pyridinium oximes as cholinesterase reactivators. Structure-activity relationship and efficacy in the treatment of poisoning with organophosphorus compounds. Curr Med Chem. 2009;16:2177-88 pubmed
    ..Their mechanism of action is reactivation of acetylcholinesterase (AChE) inhibited by organophosphorus agents...
  17. Akintunde J, Oboh G. Subchronic exposure to leachate activates key markers linked with neurological disorder in Wistar male rat. Environ Sci Pollut Res Int. 2015;22:18541-53 pubmed publisher
  18. Kopjar N, Zunec S, Mendaš G, Micek V, Kasuba V, Mikolić A, et al. Evaluation of chlorpyrifos toxicity through a 28-day study: Cholinesterase activity, oxidative stress responses, parent compound/metabolite levels, and primary DNA damage in blood and brain tissue of adult male Wistar rats. Chem Biol Interact. 2018;279:51-63 pubmed publisher
    ..015, and 0.010 mg/kg b. w./day. Following treatment, total cholinesterase activity and activities of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) were measured...
  19. Abdel Salam O, Youness E, Mohammed N, Yassen N, Khadrawy Y, El Toukhy S, et al. Novel neuroprotective and hepatoprotective effects of citric acid in acute malathion intoxication. Asian Pac J Trop Med. 2016;9:1181-1194 pubmed publisher
    ..Paraoxonase-1, acetylcholinesterase (AChE) and butyrylcholinesterase activities decreased in brain as well...
  20. de Cezaro M, Tvarijonaviciute A, Tecles F, Céron J, Eckersall D, Ferreira J, et al. Changes in biochemical analytes in calves infected by nematode parasites in field conditions. Vet Parasitol. 2016;219:1-6 pubmed publisher
    ..analytes determined were: acute phase proteins such as haptoglobin and paraoxonase type 1; the enzymes acetylcholinesterase; butyrylcholinesterase; the lipid profile (triglycerides and total, HDL, and LDL-cholesterol); serum iron ..
  21. Sun F, Ding J, Yu H, Gao R, Wang H, Pei C. Identification of new binding sites of human transferrin incubated with organophosphorus agents via Q Exactive LC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2016;1022:256-264 pubmed publisher
    Organophosphorus agents (OPs) like sarin, VX, or soman could inhibit acetylcholinesterase activity and cause poisoning...
  22. Cunha A, Felippe I, Ferreira Junior N, Resstel L, Guimarães D, Beijamini V, et al. Neuroreflex control of cardiovascular function is impaired after acute poisoning with chlorpyrifos, an organophosphorus insecticide: Possible short and long term clinical implications. Toxicology. 2018;398-399:13-22 pubmed publisher
    ..Blood samples were taken for measurements of butyrylcholinesterase (BChE) activity while acetylcholinesterase (AChE) activity was measured in brainstem samples...
  23. Onder S, Dafferner A, Schopfer L, Xiao G, Yerramalla U, Tacal O, et al. Monoclonal antibody that recognizes diethoxyphospho-tyrosine modified proteins and peptides independent of surrounding amino acids. Chem Res Toxicol. 2017;: pubmed publisher
    b>Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are irreversibly inhibited by organophosphorus pesticides through formation of a covalent bond with the active site serine...
  24. Barai P, Raval N, Acharya S, Borisa A, Bhatt H, Acharya N. Neuroprotective effects of bergenin in Alzheimer's disease: Investigation through molecular docking, in vitro and in vivo studies. Behav Brain Res. 2018;356:18-40 pubmed publisher
    ..2), CCDC for predicting its activity against targets of AD management like acetylcholinesterase (AChE) (1B41), butyrylcholinesterase (BuChE) (1P0I), Tau protein kinase 1 (GSK-3?) (1J1B), BACE-1 (1FKN) ..
  25. Cotton J, Edwards J, Rahman M, Brumby S. Cholinesterase research outreach project (CROP): point of care cholinesterase measurement in an Australian agricultural community. Environ Health. 2018;17:31 pubmed publisher
    ..Symptoms of OP toxicity are the results of inhibition of the enzyme acetylcholinesterase (AChE) which is found in many types of conducting tissue in human bodies such as nerve and muscle, central ..
  26. Soares M, Zanusso Costa M, da Silva T, Gazal M, Couto C, Nogueira Debom G, et al. Methionine and/or Methionine Sulfoxide Alter Ectoenzymes Activities in Lymphocytes and Inflammatory Parameters in Serum from Young Rats: Acute and Chronic Effects. Cell Biochem Biophys. 2018;76:243-253 pubmed publisher
    ..b>Acetylcholinesterase activity was increased in lymphocytes after 3?h and 21 days of treatment by MetO and Met?+?MetO, while ..
  27. Cohen O, Kronman C, Raveh L, Mazor O, Ordentlich A, Shafferman A. Comparison of polyethylene glycol-conjugated recombinant human acetylcholinesterase and serum human butyrylcholinesterase as bioscavengers of organophosphate compounds. Mol Pharmacol. 2006;70:1121-31 pubmed
    Comparative protection studies in mice demonstrate that on a molar basis, recombinant human acetylcholinesterase (rHuAChE) confers higher levels of protection than native human butyrylcholinesterase (HuBChE) against organophosphate (OP) ..
  28. Valiveti A, Bhalerao U, Acharya J, Karade H, Acharya B, Raviraju G, et al. Synthesis and in vitro kinetic evaluation of N-thiazolylacetamido monoquaternary pyridinium oximes as reactivators of sarin, O-ethylsarin and VX inhibited human acetylcholinesterase (hAChE). Bioorg Med Chem. 2015;23:4899-910 pubmed publisher
    ..vitro reactivation efficacies against nerve agent (sarin, O-ethylsarin and VX) inhibited human erythrocyte acetylcholinesterase (hAChE)...
  29. Araujo S, de Paula M, Poetini M, Meichtry L, Bortolotto V, Zarzecki M, et al. Effectiveness of γ-oryzanol in reducing neuromotor deficits, dopamine depletion and oxidative stress in a Drosophila melanogaster model of Parkinson's disease induced by rotenone. Neurotoxicology. 2015;51:96-105 pubmed publisher
    ..Survival and behavior analyses were carried out in vivo, and ex vivo analyses involved acetylcholinesterase activity (AChE), determination of dopaminergic levels, cellular viability and mitochondrial viability, ..
  30. Suganthy N, Sri Ramkumar V, Pugazhendhi A, Benelli G, Archunan G. Biogenic synthesis of gold nanoparticles from Terminalia arjuna bark extract: assessment of safety aspects and neuroprotective potential via antioxidant, anticholinesterase, and antiamyloidogenic effects. Environ Sci Pollut Res Int. 2018;25:10418-10433 pubmed publisher
    ..AuNPs showed dose-dependant inhibition of acetylcholinesterase and butyrylcholinesterase with IC50 value of 4.25 ± 0.02 and 5.05 ± 0...
  31. Osler M, Rozing M, Christensen G, Andersen P, Jørgensen M. Electroconvulsive therapy and risk of dementia in patients with affective disorders: a cohort study. Lancet Psychiatry. 2018;5:348-356 pubmed publisher
    ..for patients and followed up patients for incidental dementia (defined by hospital discharge diagnoses or acetylcholinesterase inhibitor use) until Oct 31, 2016...
  32. Poet T, Timchalk C, Bartels M, Smith J, McDougal R, Juberg D, et al. Use of a probabilistic PBPK/PD model to calculate Data Derived Extrapolation Factors for chlorpyrifos. Regul Toxicol Pharmacol. 2017;86:59-73 pubmed publisher
    ..major sources of parameter uncertainty and biological diversity on the pharmacodynamics of red blood cell acetylcholinesterase inhibition...
  33. Gawali N, Bulani V, Gursahani M, Deshpande P, Kothavade P, Juvekar A. Agmatine attenuates chronic unpredictable mild stress-induced anxiety, depression-like behaviours and cognitive impairment by modulating nitrergic signalling pathway. Brain Res. 2017;1663:66-77 pubmed publisher
    ..Furthermore, agmatine administration reduced the levels of acetylcholinesterase and oxidative stress markers...
  34. Silla J, Silva D, Freitas M. Theoretical Study on the Conformational Bioeffect of the Fluorination of Acetylcholine. Mol Inform. 2017;36: pubmed publisher
    ..In addition, the chemical and structural changes were evaluated on the basis of ligand-enzyme (acetylcholinesterase) interactions...
  35. Dhouib I, Annabi A, Doghri R, Rejeb I, Dallagi Y, Bdiri Y, et al. Neuroprotective effects of curcumin against acetamiprid-induced neurotoxicity and oxidative stress in the developing male rat cerebellum: biochemical, histological, and behavioral changes. Environ Sci Pollut Res Int. 2017;: pubmed publisher
    ..Additionally, curcumin reduced histopathological changes caused by ACE...
  36. Jin J, Kurobe T, Ramírez Duarte W, Bolotaolo M, Lam C, Pandey P, et al. Sub-lethal effects of herbicides penoxsulam, imazamox, fluridone and glyphosate on Delta Smelt (Hypomesus transpacificus). Aquat Toxicol. 2018;197:79-88 pubmed publisher
    ..We measured 17β-estradiol (E2) and glutathione (GSH) concentrations in liver, and acetylcholinesterase (AChE) activity in brain of female and male fish after 6 h of exposure to each of the four herbicides...
  37. Alnahhas M, Oxentenko S, Locke G, Hansel S, Schleck C, Zinsmeister A, et al. Outcomes of Ultrasound-Guided Trigger Point Injection for Abdominal Wall Pain. Dig Dis Sci. 2016;61:572-7 pubmed publisher
    ..TPI can provide significant, long-term symptom relief in a third of patients with chronic abdominal pain attributed to AWP. Somatization was inversely related to the treatment success. ..
  38. Xie Z, Lu G, Hou K, Qin D, Yan Z, Chen W. Bioconcentration, metabolism and effects of diphenhydramine on behavioral and biochemical markers in crucian carp (Carassius auratus). Sci Total Environ. 2016;544:400-9 pubmed publisher
    ..Brain acetylcholinesterase activity was also induced in DPH-exposed crucian carp with maximal induction of 174%...
  39. Ye C, Wang M, Zhong X, Chen S, Chai Y, Yuan R. Highly sensitive electrochemiluminescenc assay of acetylcholinesterase activity based on dual biomarkers using Pd-Au nanowires as immobilization platform. Biosens Bioelectron. 2016;79:34-40 pubmed publisher
    ..were prepared and applied to fabricate an electrochemiluminescence (ECL) biosensor for the detection of acetylcholinesterase (AChE) activity...
  40. Mørk A, Russell R, de Jong I, Smagin G. Effects of the 5-HT6 receptor antagonist idalopirdine on extracellular levels of monoamines, glutamate and acetylcholine in the rat medial prefrontal cortex. Eur J Pharmacol. 2017;799:1-6 pubmed publisher
    ..83nM) in phase III development for mild-to-moderate Alzheimer's disease as an adjunct therapy to acetylcholinesterase inhibitors (AChEIs)...
  41. Chintamaneni P, Krishnamurthy P, Rao P, Pindiprolu S. Surface modified nano-lipid drug conjugates of positive allosteric modulators of M1 muscarinic acetylcholine receptor for the treatment of Alzheimer's disease. Med Hypotheses. 2017;101:17-22 pubmed publisher
    ..When co-administered with AChE inhibitors they are expected to increase their efficacy and reduce their therapeutic dose and side effects. ..
  42. Silva Junior E, Barcellos Franca P, Quintans Júnior L, Mendonça Junior F, Scotti L, Scotti M, et al. Dynamic Simulation, Docking and DFT Studies Applied to a Set of Anti-Acetylcholinesterase Inhibitors in the enzyme ?-Secretase (BACE-1): An Important Therapeutic Target in Alzheimer`s disease. Curr Comput Aided Drug Des. 2017;13:266-274 pubmed publisher
    ..The action of some acetylcholinesterase inhibitors (AChEI) as ?-secretase inhibitors has been reported.
  43. Kaur R, Singh V, Shri R. Anti-amnesic effects of Ganoderma species: A possible cholinergic and antioxidant mechanism. Biomed Pharmacother. 2017;92:1055-1061 pubmed publisher
    ..ramosissimum. Extracts of selected mushroom species were evaluated for their antioxidant activity and acetylcholinesterase (AChE) inhibition using in-vitro assays (DPPH and Ellman tests respectively)...
  44. Shukla R, Gupta R, Srivastava P, Dhuriya Y, Singh A, Chandravanshi L, et al. Brain cholinergic alterations in rats subjected to repeated immobilization or forced swim stress on lambda-cyhalothrin exposure. Neurochem Int. 2016;93:51-63 pubmed publisher
    ..Decrease in acetylcholinesterase activity, protein expression of ChAT and PKC-β1 associated with decreased mRNA expression of CHRM2, AChE ..
  45. Chen Y, Zhang J, Wang Y, Yuan J, Hu W. Efficacy of Cholinesterase Inhibitors in Vascular Dementia: An Updated Meta-Analysis. Eur Neurol. 2016;75:132-41 pubmed publisher
    The objective of this study was to determine whether treatment with acetylcholinesterase inhibitors would provide cognitive benefit for patients with vascular dementia...
  46. da Costa M, Bernardi J, Costa L, Fiuza T, Brandão R, Ribeiro M, et al. N-acetylcysteine treatment attenuates the cognitive impairment and synaptic plasticity loss induced by streptozotocin. Chem Biol Interact. 2017;272:37-46 pubmed publisher
    ..Our results suggest that NAC is a promising therapeutic strategy for the treatment of AD. ..
  47. Yang F, Zeng L, Luo Z, Wang Z, Huang F, Wang Q, et al. Complex role of titanium dioxide nanoparticles in the trophic transfer of arsenic from Nannochloropsis maritima to Artemia salina nauplii. Aquat Toxicol. 2018;198:231-239 pubmed publisher
    ..Although the stress enzyme activities of superoxide dismutase (SOD) and acetylcholinesterase (AChE) in A...
  48. Wang K, Qi S, Mu X, Chai T, Yang Y, Wang D, et al. Evaluation of the Toxicity, AChE Activity and DNA Damage Caused by Imidacloprid on Earthworms, Eisenia fetida. Bull Environ Contam Toxicol. 2015;95:475-80 pubmed publisher
    ..In the present study, the effect of imidacloprid on reproduction, growth, acetylcholinesterase (AChE) and DNA damage in earthworms was assessed using an artificial soil medium...
  49. Karasova J, Hroch M, Musilek K, Kuca K. Small Quaternary Inhibitors K298 and K524: Cholinesterases Inhibition, Absorption, Brain Distribution, and Toxicity. Neurotox Res. 2016;29:267-74 pubmed publisher
    Inhibitors of acetylcholinesterase (AChE) may be used in the treatment of various cholinergic deficits, among them being myasthenia gravis (MG)...
  50. Biétry F, Pfeil A, Reich O, Schwenkglenks M, Meier C. Benzodiazepine Use and Risk of Developing Alzheimer's Disease: A Case-Control Study Based on Swiss Claims Data. CNS Drugs. 2017;31:245-251 pubmed publisher
    ..e., acetylcholinesterase inhibitors (donepezil, rivastigmine, and galantamine) and the N-methyl-D-aspartate receptor antagonist ..
  51. Ben Saad H, Kharrat N, Driss D, Gargouri M, Marrakchi R, Jammoussi K, et al. Effects of vanillin on potassium bromate-induced neurotoxicity in adult mice: impact on behavior, oxidative stress, genes expression, inflammation and fatty acid composition. Arch Physiol Biochem. 2017;123:165-174 pubmed publisher
    ..in enzymatic activities and gene expressions, Na+?-K+? and Mg2+-ATPases, acetylcholinesterase and butylcholinesterase activities...
  52. Kumar R, Kumar A, Langstrom B, Darreh Shori T. Discovery of novel choline acetyltransferase inhibitors using structure-based virtual screening. Sci Rep. 2017;7:16287 pubmed publisher
  53. Ziganshin R, Kovalchuk S, Arapidi G, Starkov V, Hoang A, Thi Nguyen T, et al. Quantitative proteomic analysis of Vietnamese krait venoms: Neurotoxins are the major components in Bungarus multicinctus and phospholipases A2 in Bungarus fasciatus. Toxicon. 2015;107:197-209 pubmed publisher
    ..fasciatus venom, phospholipase A2 was the main component (71%), followed by oxidase of l-amino acids (8%), acetylcholinesterase (5%) and metalloproteinases (4%)...
  54. Yologlu E, Ozmen M. Low concentrations of metal mixture exposures have adverse effects on selected biomarkers of Xenopus laevis tadpoles. Aquat Toxicol. 2015;168:19-27 pubmed publisher
    ..Glutathione S-transferase (GST), glutathione reductase (GR), acetylcholinesterase (AChE), carboxylesterase (CaE), glutathione peroxidase (GPx), and catalase (CAT) levels were evaluated...
  55. Krátký M, Stepánková S, Vorčáková K, Navrátilová L, Trejtnar F, Stolarikova J, et al. Synthesis of readily available fluorophenylalanine derivatives and investigation of their biological activity. Bioorg Chem. 2017;71:244-256 pubmed publisher
    ..Mycobacterium tuberculosis, non-tuberculous mycobacteria, other bacteria, fungi), for their inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) and cytotoxicity...
  56. Cui H, Wu W, Li M, Song X, Lv Y, Zhang T. A highly stable acetylcholinesterase biosensor based on chitosan-TiO2-graphene nanocomposites for detection of organophosphate pesticides. Biosens Bioelectron. 2018;99:223-229 pubmed publisher
    A highly stable electrochemical acetylcholinesterase (AChE) biosensor for detection of organophosphorus pesticides (OPs) was developed simply by adsorption of AChE on chitosan (CS), TiO2 sol-gel, and reduced graphene oxide (rGO)..
  57. Li G, Hong G, Li X, Zhang Y, Xu Z, Mao L, et al. Synthesis and activity towards Alzheimer's disease in vitro: Tacrine, phenolic acid and ligustrazine hybrids. Eur J Med Chem. 2018;148:238-254 pubmed publisher
    ..inhibition activity towards cholinesterases (ChEs), among of them, 9i was the most potent one towards acetylcholinesterase (eeAChE, IC50?=?3.9?nM; hAChE, IC50?=?65.2?nM)...
  58. Hanif K, Kumar M, Singh N, Shukla R. Effect of homeopathic Lycopodium clavatum on memory functions and cerebral blood flow in memory-impaired rats. Homeopathy. 2015;104:24-8 pubmed publisher
    ..There was increased CBF in STZ (ICV) treated rats at all the potencies of Lyc studied. The above study suggests that Lyc may be used as a drug of choice in condition of memory impairment due to its beneficial effect on CBF. ..
  59. Paoletti L, Domizi P, Marcucci H, Montaner A, Krapf D, Salvador G, et al. Lysophosphatidylcholine Drives Neuroblast Cell Fate. Mol Neurobiol. 2016;53:6316-6331 pubmed publisher
    ..leading to the generation of functional mature neurons expressing ?III-tubulin and having increased acetylcholinesterase activity and membrane biosynthesis required for neuritogenesis...
  60. Bradley S, Bourgognon J, Sanger H, Verity N, Mogg A, White D, et al. M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss. J Clin Invest. 2017;127:487-499 pubmed publisher
    ..for Alzheimer's disease (AD) is whole-body upregulation of cholinergic transmission via inhibition of acetylcholinesterase. This approach leads to profound dose-related adverse effects...
  61. Vieira J, Gutierres J, Carvalho F, Pereira L, Oliveira L, Morsch V, et al. Caffeine prevents changes in muscle caused by high-intensity interval training. Biomed Pharmacother. 2017;89:116-123 pubmed publisher
    ..we evaluated the effects of high-intensity interval training (HIIT) associated with caffeine intake on acetylcholinesterase (AChE) and Ca2+ATPase activity and glycogen levels in the muscles of rats were evaluated...
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    ..Previous work has identified that acetylcholinesterase (AChE) is expressed aberrantly in various malignant tumors and function as a tumor growth suppressor...
  64. Alizadeh A, Talebi Jahromi K, Hosseininaveh V, Ghadamyari M. Toxicological and biochemical characterizations of AChE in phosalone-susceptible and resistant populations of the common pistachio psyllid, Agonoscena pistaciae. J Insect Sci. 2014;14:18 pubmed publisher
    ..Therefore, AChE from the Rafsanjan population showed negatively correlated sensitivity, being insensitive to phosphamidon and monocrotophos and sensitive to N-methyl carbamates. ..
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    ..For the two major classes of cholinesterases, such as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), previous studies reported BChE activity is elevated in patients ..
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    ..The most encouraging compound, 20, is an AChE inhibitor with high anti-aggregation activity (55.3%). Based on the results, compound 20 may be a promising structure in further research for new anti-Alzheimer's agents. ..
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    ..The study describes synthesis and pharmacological evaluation of new compounds designed as dual binding site acetylcholinesterase inhibitors. Among the synthesized compounds, two deserve special attention--compounds 42 and 13...
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    b>Acetylcholinesterase inhibitor (AChEI) and memantine are recognized drug treatments with limited clinical efficacy...
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    ..To identify the mechanism of the memory-ameliorating effect of PLAG, acetylcholinesterase (AChE) inhibition assay and the Western blot analysis were conducted...
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    The cholinesterases, acetylcholinesterase (AChE) and butyrylcholinesterase, are primary targets of organophosphates (OPs). Exposure to OPs can lead to serious cardiovascular complications, respiratory compromise, and death...
  71. Kim K, Jeon H, Choi S, Tsang D, Oleszczuk P, Ok Y, et al. Combined toxicity of endosulfan and phenanthrene mixtures and induced molecular changes in adult Zebrafish (Danio rerio). Chemosphere. 2018;194:30-41 pubmed publisher
    ..In addition, acetylcholinesterase activity decreased in zebrafish bodies exposed to ENDO with or without PHE...
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    Accumulated evidence attributes noncatalytic morphogenic activitie(s) to acetylcholinesterase (AChE)...
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    Free radical production and high catecholamine levels are implicated with the modulation of acetylcholinesterase (AChE) activity. To investigate the effect of the mode of delivery on maternal-neonatal erythrocyte membrane AChE activity...
  74. Milelli A, De Simone A, Ticchi N, Chen H, Betari N, Andrisano V, et al. Tacrine-based Multifunctional Agents in Alzheimer's Disease: An Old Story in Continuous Development§. Curr Med Chem. 2017;24:3522-3546 pubmed publisher
    ..In particular, tacrine, a well known Acetylcholinesterase inhibitor, is one of the most used starting point to develop multifunctional ligands and hundreds of papers ..
  75. Yang C, Wang Y, Liu C, Zeng Y, Cheng P, Jiao R, et al. Strepchazolins A and B: Two New Alkaloids from a Marine Streptomyces chartreusis NA02069. Mar Drugs. 2017;15: pubmed publisher
    ..0 ?M, and weak inhibitory activity against acetylcholinesterase (AChE) in vitro with IC50 value of 50...
  76. Soares D, Portela J, Roos D, Rodrigues N, Gomes K, Macedo G, et al. Treatment with pentylenetetrazole (PTZ) and 4-aminopyridine (4-AP) differently affects survival, locomotor activity, and biochemical markers in Drosophila melanogaster. Mol Cell Biochem. 2018;442:129-142 pubmed publisher
    ..Also a significant increase in catalase and acetylcholinesterase (AChE) activities was observed in the body...
  77. Katalinić M, Zandona A, Ramić A, Zorbaz T, Primožič I, Kovarik Z. New Cinchona Oximes Evaluated as Reactivators of Acetylcholinesterase and Butyrylcholinesterase Inhibited by Organophosphorus Compounds. Molecules. 2017;22: pubmed publisher
    ..researchers have been focused on finding efficient reactivators of organophosphorus compound (OP)-inhibited acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)...
  78. Palanimuthu D, Poon R, Sahni S, Anjum R, Hibbs D, Lin H, et al. A novel class of thiosemicarbazones show multi-functional activity for the treatment of Alzheimer's disease. Eur J Med Chem. 2017;139:612-632 pubmed publisher
    ..of a novel series of thiosemicarbazones derived from 1-benzylpiperidine, a pharmacophore within the acetylcholinesterase inhibitor, Donepezil...
  79. Bonifacio A, Ballesteros M, Bonansea R, Filippi I, Amé M, Hued A. Environmental relevant concentrations of a chlorpyrifos commercial formulation affect two neotropical fish species, Cheirodon interruptus and Cnesterodon decemmaculatus. Chemosphere. 2017;188:486-493 pubmed publisher
    ..Fish behavior was evaluated through locomotor activity and space usage variables. The activity of acetylcholinesterase (AChE) in brain and muscle, catalase (CAT) and glutathione-S-transferase (GST) in brain, liver, muscle and ..
  80. Padrtova T, Marvanova P, Odehnalova K, Kubínová R, Parravicini O, Garro A, et al. Synthesis, Analysis, Cholinesterase-Inhibiting Activity and Molecular Modelling Studies of 3-(Dialkylamino)-2-hydroxypropyl 4-[(Alkoxy-carbonyl)amino]benzoates and Their Quaternary Ammonium Salts. Molecules. 2017;22: pubmed publisher
    ..Biological evaluation aimed at testing acetylcholinesterase and butyrylcholinesterase-inhibiting activity of synthesized compounds...
  81. Piccardi M, Congiu D, Squassina A, Manconi F, Putzu P, Mereu R, et al. Alzheimer's disease: case-control association study of polymorphisms in ACHE, CHAT, and BCHE genes in a Sardinian sample. Am J Med Genet B Neuropsychiatr Genet. 2007;144B:895-9 pubmed
    ..is associated with decreased levels of the neurotransmitter acetylcholine (ACh), decreased activity of acetylcholinesterase (AChE), choline acetyltransferase (ChAT), and increased butyrylcholinesterase (BChE) activity...
  82. Sanchez Hernandez J, Notario del Pino J, Capowiez Y, Mazzia C, Rault M. Soil enzyme dynamics in chlorpyrifos-treated soils under the influence of earthworms. Sci Total Environ. 2018;612:1407-1416 pubmed publisher
    ..e., 90% inhibition in muscle acetylcholinesterase and carboxylesterase (CbE) activities...
  83. Piplani P, Jain A, Devi D, Anjali -, Sharma A, Silakari P. Design, synthesis and pharmacological evaluation of some novel indanone derivatives as acetylcholinesterase inhibitors for the management of cognitive dysfunction. Bioorg Med Chem. 2018;26:215-224 pubmed publisher
    ..All the synthesised compounds were evaluated for their in vitro acetylcholinesterase (AChE) inhibition at five different concentrations using mice brain homogenate as the source of the enzyme...
  84. Chhajlani V, Derr D, Earles B, Schmell E, August T. Purification and partial amino acid sequence analysis of human erythrocyte acetylcholinesterase. FEBS Lett. 1989;247:279-82 pubmed
    A single step immunoaffinity purification procedure for human erythrocyte acetylcholinesterase is described which permitted the isolation of milligram quantities of enzyme from 10 U of erythrocytes, with 113,000-fold purification and a ..
  85. Santos S, Vala I, Miguel C, Barata J, Garção P, Agostinho P, et al. Expression and subcellular localization of a novel nuclear acetylcholinesterase protein. J Biol Chem. 2007;282:25597-603 pubmed
    ..In this study we investigated the expression and subcellular localization of acetylcholinesterase (AChE) in endothelial cells...
  86. Basaure P, Peris Sampedro F, Cabre M, Reverte I, Colomina M. Two cholinesterase inhibitors trigger dissimilar effects on behavior and body weight in C57BL/6 mice: The case of chlorpyrifos and rivastigmine. Behav Brain Res. 2017;318:1-11 pubmed publisher
    ..Both rivastigmine doses induced a time-dependent weight increase. CPF and rivastigmine inhibited brain acetylcholinesterase following an isoform-specific pattern...
  87. Worek F, Wosar A, Baumann M, Thiermann H, Wille T. Development of a sensitive, generic and easy to use organophosphate skin disclosure kit. Toxicol Lett. 2017;280:190-194 pubmed publisher
    ..The ready-to-use kit has a weight of 16g and a size of 10×12×1cm. In the end, this kit has the potential to fill a major gap and to enable timely detection of OP skin exposure and initiation of life-saving countermeasures. ..
  88. Gajbhiye K, Gajbhiye V, Siddiqui I, Pilla S, Soni V. Ascorbic acid tethered polymeric nanoparticles enable efficient brain delivery of galantamine: An in vitro-in vivo study. Sci Rep. 2017;7:11086 pubmed publisher
    ..Hence, the results suggested that targeting of bioactives to the brain by ascorbic acid grafted PLGA-b-PEG NPs is a promising approach. ..
  89. Maćczak A, Duchnowicz P, Sicinska P, Koter Michalak M, Bukowska B, Michałowicz J. The in vitro comparative study of the effect of BPA, BPS, BPF and BPAF on human erythrocyte membrane; perturbations in membrane fluidity, alterations in conformational state and damage to proteins, changes in ATP level and Na+/K+ ATPase and AChE acti. Food Chem Toxicol. 2017;110:351-359 pubmed publisher
    ..It has been shown that the strongest changes were noted in cells treated with BPAF, while BPS caused the weakest (or none) alterations in the parameters studied...
  90. Mirahmadi S, Shahmohammadi A, Rousta A, Azadi M, Fahanik Babaei J, Baluchnejadmojarad T, et al. Soy isoflavone genistein attenuates lipopolysaccharide-induced cognitive impairments in the rat via exerting anti-oxidative and anti-inflammatory effects. Cytokine. 2018;104:151-159 pubmed publisher
    ..Furthermore, genistein ameliorated hippocampal acetylcholinesterase (AChE) activity in LPS-challenged rats...
  91. Dong J, Cai L, Li X, Wang J, Mei R, Ding Z. Monoterpene esters and aporphine alkaloids from Illigera aromatica with inhibitory effects against cholinesterase and NO production in LPS-stimulated RAW264.7 macrophages. Arch Pharm Res. 2017;40:1394-1402 pubmed publisher
    ..74 ± 1.66 and 40.28 ± 2.73 ?M, respectively. This paper provides a chemical structure and bioactive foundation for using I. aromatica as an herbal medicine. ..
  92. Bharkavi C, Vivek Kumar S, Ashraf Ali M, Osman H, Muthusubramanian S, Perumal S. One-pot microwave assisted stereoselective synthesis of novel dihydro-2'H-spiro[indene-2,1'-pyrrolo-[3,4-c]pyrrole]-tetraones and evaluation of their antimycobacterial activity and inhibition of AChE. Bioorg Med Chem Lett. 2017;27:3071-3075 pubmed publisher
    ..Compound 4h displays maximum AchE inhibitory activity with IC50 value of 0.78±0.01µmol/L. ..