ACAA1

Summary

Gene Symbol: ACAA1
Description: acetyl-CoA acyltransferase 1
Alias: ACAA, PTHIO, THIO, 3-ketoacyl-CoA thiolase, peroxisomal, acetyl-Coenzyme A acyltransferase 1, beta-ketothiolase, peroxisomal 3-oxoacyl-CoA thiolase, peroxisomal 3-oxoacyl-Coenzyme A thiolase, testicular tissue protein Li 197
Species: human
Products:     ACAA1

Top Publications

  1. Thorsheim K, Willen D, Tykesson E, Ståhle J, Praly J, Vidal S, et al. Naphthyl thio- and carba-xylopyranosides for exploration of the active site of β-1,4-galactosyltransferase 7 (β4GalT7). Chemistry. 2017;: pubmed publisher
    ..Favorable π-π interactions between the 2-naphthyl moiety and a tyrosine side chain were observed for the thio analogs, which open up for design of efficient GAG primers and inhibitors.
  2. Bout A, Teunissen Y, Hashimoto T, Benne R, Tager J. Nucleotide sequence of human peroxisomal 3-oxoacyl-CoA thiolase. Nucleic Acids Res. 1988;16:10369 pubmed
  3. Teixeira F, Marcos P, Ascenso J, Brancatelli G, Hickey N, Geremia S. Selective Binding of Spherical and Linear Anions by Tetraphenyl(thio)urea-Based Dihomooxacalix[4]arene Receptors. J Org Chem. 2017;82:11383-11390 pubmed publisher
    Three novel tetra(thio)ureido dihomooxacalix[4]arene anion receptors (phenylurea 4a, phenylthiourea 4b, and tert-butylurea 4c) were synthesized and obtained in the cone conformation in solution, as shown by NMR studies...
  4. Shen H, Du G, Liu K, Ye L, Xie S, Jiang L. Synthesis and evaluation of pseudopeptide chiral stationary phases for enantioselective resolution. J Chromatogr A. 2017;1521:53-62 pubmed publisher
    ..polymers were subsequently immobilized onto mercaptopropylated silica bead matrices by means of thio-click chemistry and their potential as the chiral stationary phase (CSP) for high-performance liquid chromatography ..
  5. Bege M, Bereczki I, Herczeg M, Kicsák M, Eszenyi D, Herczegh P, et al. A low-temperature, photoinduced thiol-ene click reaction: a mild and efficient method for the synthesis of sugar-modified nucleosides. Org Biomol Chem. 2017;15:9226-9233 pubmed publisher
    ..coupling was applied for the first time on nucleoside enofuranoside derivatives to produce a broad range of thio-substituted d-ribo, -arabino, -xylo and l-lyxo configured pyrimidine nucleosides...
  6. Fu D, Song J, Hou Y, Zhao R, Li J, Mao R, et al. Discovery of 5,6-diaryl-1,2,4-triazines hybrids as potential apoptosis inducers. Eur J Med Chem. 2017;138:1076-1088 pubmed publisher
    ..Among these chemical derivatives, 3-(((1-(4-fluorobenzyl)-1H-1,2,3-triazol-4-yl)methyl)thio)-5,6-diphenyl-1,2,4-triazine (11E) showed the more potent inhibitory effect against three cell lines than 5-Fu...
  7. Kinoshita A, Higashino M, Yoshida K, Aratani Y, Kakuuchi A, Hanada K, et al. Synthesis and evaluation of a potent, well-balanced EP2/EP3 dual agonist. Bioorg Med Chem. 2018;26:200-214 pubmed publisher
    ..As the result, 2-[(2-{(1R,2R)-2-[(1E,4S)-5-cyclopentyl-4-hydroxy-4-methyl-1-penten-1-yl]-5-oxocyclopentyl}eth-yl)thio]-1,3-thiazole-4-carboxylic acid (10) showed excellent potency (human EC50 EP2 = 1...
  8. Kalvass J, Olson E, Cassidy M, Selley D, Pollack G. Pharmacokinetics and pharmacodynamics of seven opioids in P-glycoprotein-competent mice: assessment of unbound brain EC50,u and correlation of in vitro, preclinical, and clinical data. J Pharmacol Exp Ther. 2007;323:346-55 pubmed
    ..of opioid binding affinity (Ki) and functional activity [EC50 for agonist stimulated guanosine 5'-O-(3-[35S]thio)triphosphate binding] and relevant clinical parameters were obtained to construct in vitro-to-preclinical and ..
  9. Arman H, Poplaukhin P, Tiekink E. Crystal structures of {μ2-N,N'-bis-[(pyridin-3-yl)meth-yl]ethanedi-amide}tetra-kis-(di-methyl-carbamodi-thio-ato)dizinc(II) di-methyl-formamide disolvate and {μ2-N,N'-bis-[(pyridin-3-yl)meth-yl]ethanedi-amide}tetra-kis-(di-n-propyl-carbamodi-thio-ato. Acta Crystallogr E Crystallogr Commun. 2017;73:1501-1507 pubmed publisher
    ..In each of (I) and (II), the di-thio-carbamate ligands are chelating with varying degrees of symmetry, so the zinc atom is within an NS4 set ..
  10. Kumura K, Wakiyama Y, Ueda K, Umemura E, Hirai Y, Yamada K, et al. Synthesis and antibacterial activity of novel lincomycin derivatives. IV. Optimization of an N-6 substituent. J Antibiot (Tokyo). 2017;: pubmed publisher
    ..A substituent at the C-7 position is a 5-aryl-1,3,4-thiadiazol-2-yl-thio group that generates antibacterial activities against macrolide-resistant Streptococcus pneumoniae and ..

Detail Information

Publications62

  1. Thorsheim K, Willen D, Tykesson E, Ståhle J, Praly J, Vidal S, et al. Naphthyl thio- and carba-xylopyranosides for exploration of the active site of β-1,4-galactosyltransferase 7 (β4GalT7). Chemistry. 2017;: pubmed publisher
    ..Favorable π-π interactions between the 2-naphthyl moiety and a tyrosine side chain were observed for the thio analogs, which open up for design of efficient GAG primers and inhibitors.
  2. Bout A, Teunissen Y, Hashimoto T, Benne R, Tager J. Nucleotide sequence of human peroxisomal 3-oxoacyl-CoA thiolase. Nucleic Acids Res. 1988;16:10369 pubmed
  3. Teixeira F, Marcos P, Ascenso J, Brancatelli G, Hickey N, Geremia S. Selective Binding of Spherical and Linear Anions by Tetraphenyl(thio)urea-Based Dihomooxacalix[4]arene Receptors. J Org Chem. 2017;82:11383-11390 pubmed publisher
    Three novel tetra(thio)ureido dihomooxacalix[4]arene anion receptors (phenylurea 4a, phenylthiourea 4b, and tert-butylurea 4c) were synthesized and obtained in the cone conformation in solution, as shown by NMR studies...
  4. Shen H, Du G, Liu K, Ye L, Xie S, Jiang L. Synthesis and evaluation of pseudopeptide chiral stationary phases for enantioselective resolution. J Chromatogr A. 2017;1521:53-62 pubmed publisher
    ..polymers were subsequently immobilized onto mercaptopropylated silica bead matrices by means of thio-click chemistry and their potential as the chiral stationary phase (CSP) for high-performance liquid chromatography ..
  5. Bege M, Bereczki I, Herczeg M, Kicsák M, Eszenyi D, Herczegh P, et al. A low-temperature, photoinduced thiol-ene click reaction: a mild and efficient method for the synthesis of sugar-modified nucleosides. Org Biomol Chem. 2017;15:9226-9233 pubmed publisher
    ..coupling was applied for the first time on nucleoside enofuranoside derivatives to produce a broad range of thio-substituted d-ribo, -arabino, -xylo and l-lyxo configured pyrimidine nucleosides...
  6. Fu D, Song J, Hou Y, Zhao R, Li J, Mao R, et al. Discovery of 5,6-diaryl-1,2,4-triazines hybrids as potential apoptosis inducers. Eur J Med Chem. 2017;138:1076-1088 pubmed publisher
    ..Among these chemical derivatives, 3-(((1-(4-fluorobenzyl)-1H-1,2,3-triazol-4-yl)methyl)thio)-5,6-diphenyl-1,2,4-triazine (11E) showed the more potent inhibitory effect against three cell lines than 5-Fu...
  7. Kinoshita A, Higashino M, Yoshida K, Aratani Y, Kakuuchi A, Hanada K, et al. Synthesis and evaluation of a potent, well-balanced EP2/EP3 dual agonist. Bioorg Med Chem. 2018;26:200-214 pubmed publisher
    ..As the result, 2-[(2-{(1R,2R)-2-[(1E,4S)-5-cyclopentyl-4-hydroxy-4-methyl-1-penten-1-yl]-5-oxocyclopentyl}eth-yl)thio]-1,3-thiazole-4-carboxylic acid (10) showed excellent potency (human EC50 EP2 = 1...
  8. Kalvass J, Olson E, Cassidy M, Selley D, Pollack G. Pharmacokinetics and pharmacodynamics of seven opioids in P-glycoprotein-competent mice: assessment of unbound brain EC50,u and correlation of in vitro, preclinical, and clinical data. J Pharmacol Exp Ther. 2007;323:346-55 pubmed
    ..of opioid binding affinity (Ki) and functional activity [EC50 for agonist stimulated guanosine 5'-O-(3-[35S]thio)triphosphate binding] and relevant clinical parameters were obtained to construct in vitro-to-preclinical and ..
  9. Arman H, Poplaukhin P, Tiekink E. Crystal structures of {μ2-N,N'-bis-[(pyridin-3-yl)meth-yl]ethanedi-amide}tetra-kis-(di-methyl-carbamodi-thio-ato)dizinc(II) di-methyl-formamide disolvate and {μ2-N,N'-bis-[(pyridin-3-yl)meth-yl]ethanedi-amide}tetra-kis-(di-n-propyl-carbamodi-thio-ato. Acta Crystallogr E Crystallogr Commun. 2017;73:1501-1507 pubmed publisher
    ..In each of (I) and (II), the di-thio-carbamate ligands are chelating with varying degrees of symmetry, so the zinc atom is within an NS4 set ..
  10. Kumura K, Wakiyama Y, Ueda K, Umemura E, Hirai Y, Yamada K, et al. Synthesis and antibacterial activity of novel lincomycin derivatives. IV. Optimization of an N-6 substituent. J Antibiot (Tokyo). 2017;: pubmed publisher
    ..A substituent at the C-7 position is a 5-aryl-1,3,4-thiadiazol-2-yl-thio group that generates antibacterial activities against macrolide-resistant Streptococcus pneumoniae and ..
  11. Pascoe D, Ling K, Cockroft S. The Origin of Chalcogen-Bonding Interactions. J Am Chem Soc. 2017;139:15160-15167 pubmed publisher
    ..chalcogen-bonding interactions being dominated by n → σ* orbital delocalization between a lone pair (n) of a (thio)amide donor and the antibonding σ* orbital of an acceptor thiophene or selenophene...
  12. Du L, Gao Z, Paoletta S, Wan T, Gizewski E, Barbour S, et al. Species differences and mechanism of action of A3 adenosine receptor allosteric modulators. Purinergic Signal. 2017;: pubmed publisher
    ..In guanosine 5'-[γ-[35S]thio]triphosphate ([35S]GTPγS) binding assays with cell membranes isolated from human embryonic kidney cells ..
  13. Amatori S, Ambrosi G, Errico Provenzano A, Fanelli M, Formica M, Fusi V, et al. PdII and PtII complexes with a thio-aza macrocycle ligand containing an intercalating fragment: Structural and antitumor activity studies. J Inorg Biochem. 2016;162:154-161 pubmed publisher
    ..They were obtained using the thio-aza macrocycle 9,18-dimethyl-12,17dithia-9,18,27,28-tetraaaza-29-oxatetracyclo[24.2.1.02,7...
  14. Liu M, Wang J, Liu P. HPLC method development, validation, and impurity characterization of a potent antitumor nucleoside, T-dCyd (NSC 764276). J Pharm Biomed Anal. 2016;131:429-435 pubmed publisher
    An HPLC method for the assay of an anticancer nucleoside, 4'-thio-2'-deoxycytidine (T-dCyd, NSC 764276), has been developed and validated...
  15. Muller S, Ebert F, Raber G, Meyer S, Bornhorst J, Hüwel S, et al. Effects of arsenolipids on in vitro blood-brain barrier model. Arch Toxicol. 2017;: pubmed publisher
    ..AsHC 360, AsHC 444, and two arsenic-containing fatty acids, AsFA 362 and AsFA 388) as well as of their metabolites (thio/oxo-dimethylpropionic acid, dimethylarsinic acid) on porcine brain capillary endothelial cells (PBCECs, in vitro ..
  16. Prywes N, Michaels Y, Pal A, Oh S, Szostak J. Thiolated uridine substrates and templates improve the rate and fidelity of ribozyme-catalyzed RNA copying. Chem Commun (Camb). 2016;52:6529-32 pubmed publisher
    ..Here we demonstrate that two alternative bases, 2-thio-uridine (s(2)U) and 2-thio-ribo-thymidine (s(2)T), improve the rate and fidelity of ribozyme catalyzed nucleotide ..
  17. He W, Zhuang J, Du H, Yang Z, Xu J. Stereochemistry and mechanistic insights in the [2t + 2i + 2i] annulations of thioketenes and imines. Org Biomol Chem. 2017;15:9424-9432 pubmed publisher
    ..The annuloselectivity of thio-Staudinger cycloadditions is dependent on the substituents of both thioketenes and imines...
  18. He T, Misuraca J, Musah R. "Carboranyl-cysteine"-Synthesis, Structure and Self-Assembly Behavior of a Novel α-Amino Acid. Sci Rep. 2017;7:16995 pubmed publisher
    ..of the thiol proton in cysteine with m-carborane furnished 2-amino-3-(1,7-dicarba-closo-dodecacarboranyl-1-thio)propanoic acid (3), a boron cluster amino acid that exhibits self-assembly to form micron-sized constructs...
  19. Erat M, Besic E, Oberhuber M, Johannsen S, Sigel R. Specific phosphorothioate substitution within domain 6 of a group II intron ribozyme leads to changes in local structure and metal ion binding. J Biol Inorg Chem. 2018;23:167-177 pubmed publisher
    ..a D6-27 construct where all R P oxygens of the uridine phosphate groups are replaced by sulfur (α-thio-D6-27). We determined its NMR structure, the second RNA-only structure containing thiophosphate groups...
  20. Davies K, Linder M, Kryman M, Detty M. Extended rhodamine photosensitizers for photodynamic therapy of cancer cells. Bioorg Med Chem. 2016;24:3908-3917 pubmed publisher
    Extended thio- and selenorhodamines with a linear or angular fused benzo group were prepared. The absorption maxima for these compounds fell between 640 and 700nm...
  21. Meguro Y, Noguchi M, Li G, Shoda S. Glycosyl Bunte Salts: A Class of Intermediates for Sugar Chemistry. Org Lett. 2017;: pubmed publisher
    ..The application of glycosyl Bunte salts is demonstrated with transformation reactions into other glycosyl compounds such as a 1-thio sugar, a glycosyl disulfide, a 1,6-anhydro sugar, and an O-glycoside.
  22. Masoodi K, Eisermann K, Yang Z, Dar J, Pascal L, Nguyen M, et al. Inhibition of Androgen Receptor Function and Level in Castration-Resistant Prostate Cancer Cells by 2-[(isoxazol-4-ylmethyl)thio]-1-(4-phenylpiperazin-1-yl)ethanone. Endocrinology. 2017;158:3152-3161 pubmed publisher
    ..screening of a 220,000-member small molecule library, we have previously identified 2-[(isoxazol-4-ylmethyl)thio]-1-(4-phenylpiperazin-1-yl)ethanone (IMTPPE) (SID 3712502) as a novel small molecule capable of inhibiting AR ..
  23. Ottone F, Raimondi E, Rocchi M, Giussani F, Malcovati M, Tenchini M. Refined localization of human peroxisomal 3-oxoacyl-CoA thiolase (ACAA) to 3p22. Hum Hered. 1995;45:75-9 pubmed
    The chromosomal localisation of the human gene coding for peroxisomal 3-oxoacyl-CoA thiolase (ACAA) was determined by human-hamster somatic cell hybrids and fluorescence in situ hybridisation, using cDNA and genomic probes, respectively...
  24. Wanders R, Waterham H. Biochemistry of mammalian peroxisomes revisited. Annu Rev Biochem. 2006;75:295-332 pubmed
    ....
  25. Nishi T, Tsukuda T, Nishikawa M, Tsubomura T. Crystal structure of [N,N-bis-(di-phenyl-phospho-ro-thio-yl)amidato-κ2S,S']bis-(tri-phenyl-phosphane-κP)copper(I) di-chloro-methane monosolvate. Acta Crystallogr E Crystallogr Commun. 2017;73:1105-1107 pubmed publisher
    ..3167 (9) and 2.2969 (9) Å] coordinate to the copper(I) atom, resulting in a tetra-hedral coordination geometry. The crystallographically observed mol-ecular structure is compared to the results of DFT calculations...
  26. Ramisetti S, Pandey M, Lee S, Karelia D, Narayan S, Amin S, et al. Design and synthesis of novel thiobarbituric acid derivatives targeting both wild-type and BRAF-mutated melanoma cells. Eur J Med Chem. 2018;143:1919-1930 pubmed publisher
    A series of novel thio- and seleno-barbituric acid derivatives were synthesized by varying the substituents at N1 and N3 (ethyl, methyl, allyl, and phenyl), and C5 tethered with dienyl and trienyl moieties attached to substituents such as ..
  27. Tan Y, Tiekink E. Crystal structure of (4,4'-bipyridyl-κN)bis-[N-(2-hydroxy-ethyl)-N-iso-propyl-dithio-carbamato-κ2S,S']zinc(II)-4,4'-bipyridyl (2/1) and its isostructural cadmium(II) analogue. Acta Crystallogr E Crystallogr Commun. 2017;73:1642-1646 pubmed publisher
    ..The coordination geometry about the metal atom is defined by two non-symmetrically chelating di-thio-carbamate ligands and a pyridyl N atom...
  28. Kaczmarek R, Krakowiak A, Korczynski D, Baraniak J, Nawrot B. Phosphorothioate analogs of P1,P3-di(nucleosid-5'-yl) triphosphates: Synthesis, assignment of the absolute configuration at P-atoms and P-stereodependent recognition by Fhit hydrolase. Bioorg Med Chem. 2016;24:5068-5075 pubmed publisher
    ..Their structural analogs may serve as molecular probes and potential therapeutic agents. Three P1,P3-bis-thio-analogs of symmetrical di(nucleosid-5'-yl) triphosphates (NP3N) bearing adenosine, guanosine or ..
  29. Tsetseris L. Two-dimensional cyanates: stabilization through hydrogenation. Phys Chem Chem Phys. 2016;18:14662-6 pubmed publisher
    According to first-principles calculations, it should be possible to grow two-dimensional (2D) forms of copper thio-cyanate (CuSCN) and copper seleno-cyanate (CuSeCN) since their energies are only marginally higher than those of their ..
  30. Bühning M, Friemel M, Leimkuhler S. Functional Complementation Studies Reveal Different Interaction Partners of Escherichia coli IscS and Human NFS1. Biochemistry. 2017;56:4592-4605 pubmed publisher
    ..also located in smaller amounts in the cytosol with a role in Moco biosynthesis and mcm5s2U34 thio modifications of nucleosides in tRNA...
  31. Lawrence J, Li Y, Chen S, DeLuca J, Berger J, Umbenhauer D, et al. Differential gene regulation in human versus rodent hepatocytes by peroxisome proliferator-activated receptor (PPAR) alpha. PPAR alpha fails to induce peroxisome proliferation-associated genes in human cells independently of the level of receptor exp. J Biol Chem. 2001;276:31521-7 pubmed
    ..Furthermore, other peroxisome proliferation (PP)-associated genes including peroxisomal 3-oxoacyl-CoA thiolase (THIO), peroxisomal enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase (HD), peroxisomal membrane protein-70 (PMP-70) ..
  32. Schweizer U, Bohleber S, Fradejas Villar N. The modified base isopentenyladenosine and its derivatives in tRNA. RNA Biol. 2017;14:1197-1208 pubmed publisher
    ..present in a fraction of tRNAs in bacteria and eukaryotes, which can be further modified to 2-methyl-thio-N6-isopentenyladenosine (ms2i6A) in a subset of tRNAs...
  33. Fairbairn L, Tanner M. Complete cDNA sequence of human foetal liver peroxisomal 3-oxoacyl-CoA thiolase. Nucleic Acids Res. 1989;17:3588 pubmed
  34. Liu Z, Xue Q, Guo Y. Sensitive electrochemical detection of rutin and isoquercitrin based on SH-β-cyclodextrin functionalized graphene-palladium nanoparticles. Biosens Bioelectron. 2017;89:444-452 pubmed publisher
    In this study, a sensitive electrochemical method based on thio-β-cyclodextrin functionalized graphene/palladium nanoparticles (SH-β-CD-Gr/PdNPs) was developed to detect rutin and isoquercitrin, respectively...
  35. Wang C, Jiang H, Jin J, Xie Y, Chen Z, Zhang H, et al. Development of Potent Type I Protein Arginine Methyltransferase (PRMT) Inhibitors of Leukemia Cell Proliferation. J Med Chem. 2017;60:8888-8905 pubmed publisher
    ..Here, we report the discovery of N1-(2-((2-chlorophenyl)thio)benzyl)-N1-methylethane-1,2-diamine (28d, DCPR049_12), a highly potent inhibitor of type I PRMTs that ..
  36. Truong V, Li F, Ercole F, Forsythe J. Visible-light-mediated cleavage of polymer chains under physiological conditions via quinone photoreduction and trimethyl lock. Chem Commun (Camb). 2017;53:12076-12079 pubmed publisher
    We introduce a click and visible-light triggered unclick approach via thio-bromo reaction and hydroquinone photoreduction/trimethyl lock cleavage for polymer modifications...
  37. Chen X, Li Q, Gong Y. Coordination Structure and Fragmentation Chemistry of the Tripositive Lanthanide-Thio-Diglycolamide Complexes. J Phys Chem A. 2017;: pubmed publisher
    Tripositive Ln(TMTDA)33+ complexes (Ln = La-Lu except Pm, TMTDA= tetramethyl 3-thio-diglycolamide) were observed in the gas phase by electrospray ionization (ESI) of LnCl3 and TMTDA mixtures...
  38. Lipke A, Makarska Bialokoz M, Sierakowska A, Jasiewicz B. Non-covalent interactions between thio-caffeine derivatives and water-soluble porphyrin in ethanol-water environment. Spectrochim Acta A Mol Biomol Spectrosc. 2018;192:304-311 pubmed publisher
    ..tetra-p-tosylate (H2TTMePP) and a series of five structurally diverse thio-caffeine analogues has been studied in ethanol and ethanol-water solutions, analyzing its absorption and steady-..
  39. Hübscher J, Augustin A, Seichter W, Weber E. Crystal structure of a new polymorph of di(thio-phen-3-yl) ketone. Acta Crystallogr E Crystallogr Commun. 2017;73:1560-1562 pubmed publisher
    ..The thio-phene rings are perfectly planar and twisted with respect to each other, showing the mol-ecule to be in an S,O-..
  40. Fujiwara C, Imamura A, Hashiguchi N, Shimozawa N, Suzuki Y, Kondo N, et al. Catalase-less peroxisomes. Implication in the milder forms of peroxisome biogenesis disorder. J Biol Chem. 2000;275:37271-7 pubmed
    ..Thus, we conclude that in 65TS, catalase-less peroxisomes are the direct precursors of peroxisomes...
  41. Liebing P. Crystal structure of dipotassium N-carbodi-thio-ato-l-prolinate trihydrate. Acta Crystallogr E Crystallogr Commun. 2017;73:1375-1378 pubmed publisher
    The mol-ecular and crystal structure of the l-proline-derived di-thio-carbamate-carboxyl-ate compound poly[tri-μ-aqua-(μ-2-carboxyl-atopyrrolidine-1-carbodi-thio-ato)dipotassium], [K2(C6H7NO2S<..
  42. Romero M, Jimenez R, Toral M, León Gómez E, Gómez Guzmán M, Sanchez M, et al. Vascular and Central Activation of Peroxisome Proliferator-Activated Receptor-β Attenuates Angiotensin II-Induced Hypertension: Role of RGS-5. J Pharmacol Exp Ther. 2016;358:151-63 pubmed publisher
    ..five groups (control mice, PPARβ agonist [4-[[[2-[3-Fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy]acetic acid (GW0742)-treated mice AngII-infused mice, GW0742-treated AngII-infused mice, and AngII-..
  43. Mohammed A, Sneathen J, Frojen S, Kuo L, Dupureur C. Stereospecific cholinesterase inhibition by O,S-diethylphenylphosphonothioate. Bioorg Med Chem. 2017;25:3053-3058 pubmed publisher
    ..Second order rate constants calculated from these values are similar to those obtained previously using other thio-substituted OPs with bulky groups...
  44. Rozga Wijas K, Stanczyk W, Kurjata J, Kazmierski S. Star-Shaped and Linear POSS-Polylactide Hybrid Copolymers. Materials (Basel). 2015;8:4400-4420 pubmed publisher
    Novel octakis-2[(6-hydroxyhexyl)thio]ethyl-octasilsesquioxane (POSS-S-OH) as well as heptaisobutyl-2[(6-hydroxyhexyl)thio]ethyl-octasilsesquioxane (iBu-POSS-S-OH) were synthesized. POSS structures, bearing both types of groups i.e...
  45. Li L, Nakaji Hirabayashi T, Kitano H, Ohno K, Saruwatari Y, Matsuoka K. A novel approach for UV-patterning with binary polymer brushes. Colloids Surf B Biointerfaces. 2017;161:42-50 pubmed publisher
    ..for atom transfer radical polymerization (ATRP) and an agent (6-(triethoxysilyl)hexyl 2-(((methylthio)carbonothioyl)thio)-2-phenylacetate) for reversible addition-fragmentation chain transfer (RAFT) polymerization was constructed on the ..
  46. Suhud K, Hasbullah S, Ahmad M, Heng L, Kassim M. Crystal structure of 4-meth-oxy-N-(piperidine-1-carbono-thio-yl)benzamide. Acta Crystallogr E Crystallogr Commun. 2017;73:1530-1533 pubmed publisher
    ..The layers are linked by offset π-π inter-actions [inter-centroid distance = 3.927 (3) Å], forming a supra-molecular three-dimensional structure...
  47. Kuan F, Jotani M, Tiekink E. New monoclinic form of {O-Ethyl N-(4-nitro-phen-yl)thio-carbamato-κS}(tri-4-tolyl-phosphane-κP)gold(I): crystal structure and Hirshfeld surface analysis. Acta Crystallogr E Crystallogr Commun. 2017;73:1465-1471 pubmed publisher
    ....
  48. Farasat A, Rahbarizadeh F, Ahmadvand D, Yazdian F. Optimization of an anti-HER2 nanobody expression using the Taguchi method. Prep Biochem Biotechnol. 2017;47:795-803 pubmed publisher
    ..4 mM isopropyl-β-D-thio-galactoside for 18 h at 24°C, production yield further increased by about 9% (25...
  49. Cardoso L, Noguiera T, Kaiser C, Wardell J, De Souza M, Harrison W. Crystal structures and Hirshfeld surfaces of differently substituted (E)-N'-benzyl-idene-N-methyl-2-(thio-phen-2-yl)acetohydrazides. Acta Crystallogr E Crystallogr Commun. 2017;73:1636-1641 pubmed publisher
    The syntheses and crystal structures of (E)-N'-(3-cyano-benzyl-idene)-N-methyl-2-(thio-phen-2-yl)acetohydrazide, C15H13N3OS, (I), and (E)-N'-(4-meth-oxy-benzyl-idene)-..
  50. Koeller S, Lescure M, Davies C, Desvergne J, Massip S, Bibal B. Insight into the deprotonation at the half-equivalence point of (thio)amido-benzimidazoles in the presence of anions. Org Biomol Chem. 2017;15:7263-7266 pubmed publisher
    Three crystallographic structures highlight the acid-base half-equivalence point of hydrogen-bond donor (thio)amido-benzimidazoles induced by fluoride or benzoate salts with concomitant hydrogen-bonding and deprotonation as a merged ..
  51. Aulakh J, Lobana T, Sood H, Arora D, Smolinski V, Duff C, et al. Synthesis, structures, and ESI-mass studies of silver(I) derivatives of imidazolidine-2-thiones: Antimicrobial potential and biosafety evaluation. J Inorg Biochem. 2017;178:18-31 pubmed publisher
    ..The thio-ligands are terminally S-bonded in all the complexes...
  52. Ravishankar D, Salamah M, Attina A, Pothi R, Vallance T, Javed M, et al. Ruthenium-conjugated chrysin analogues modulate platelet activity, thrombus formation and haemostasis with enhanced efficacy. Sci Rep. 2017;7:5738 pubmed publisher
    ..In order to increase the efficacy of chrysin, a sulfur derivative (thio-chrysin), and ruthenium-complexes (Ru-chrysin and Ru-thio-chrysin) were synthesised and their effects on the ..
  53. Riyadh S, Hughes D, Said M. Crystal structure of a 1,1,2,2-tetra-chloro-ethane-solvated hydrazinecarbo-thio-amide compound. Acta Crystallogr E Crystallogr Commun. 2017;73:1271-1274 pubmed publisher
    The title compound, [(1-{4-[2-(2,4-di-hydroxy-phen-yl)diazen-1-yl]phen-yl}ethyl-idene)amino]-thio-urea, 1,1,2,2-tetra-chloro-ethane monosolvate, C15H15N5O2S·C2H2Cl4
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    ..b>Thio-barbiturate-derived compounds 5-[4-hydroxy-3-methoxybenzy]-2-thioxodihydropyrimidine-4,6[1H,5H]-dione ..
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    ....
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    ..interact with the non-bridging oxygen atoms in the scissile phosphate, and these DNAzymes often have a very strong thio effect that cannot be rescued by adding thiophilic metals...
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    ..e., thio-containing 4-nitrothiophenol (NT), nitrogen-containing hydrophobic chromophore cyanine 7 monoacid (Cy7), and alkyl ..
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    In the title compound, C7H8N4S2, the thio-phene ring shows rotational disorder over two orientations in a 0.6957 (15):0.3043 (15) ratio...
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    Tetra-kis(2-methyl-prop-yl)thio-per-oxy-dicarbonic di-amide, or tetra-iso-butyl-thiuram di-sulfide, C18H36N2S4, crystallizes in a general position in the triclinic space group P-1 but ..
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    A novel series of 2-thio-5-thiomethyl substituted imidazoles was discovered to be potent TGR5 agonists that possessed glucose-lowering effects while inhibiting gall bladder emptying in mice.