ABCG1

Summary

Gene Symbol: ABCG1
Description: ATP binding cassette subfamily G member 1
Alias: ABC8, WHITE1, ATP-binding cassette sub-family G member 1, ABC transporter 8, ATP-binding cassette transporter 8, ATP-binding cassette transporter member 1 of subfamily G, ATP-binding cassette, sub-family G (WHITE), member 1, homolog of Drosophila white, white protein homolog (ATP-binding cassette transporter 8)
Species: human
Products:     ABCG1

Top Publications

  1. Tansley G, Burgess B, Bryan M, Su Y, Hirsch Reinshagen V, Pearce J, et al. The cholesterol transporter ABCG1 modulates the subcellular distribution and proteolytic processing of beta-amyloid precursor protein. J Lipid Res. 2007;48:1022-34 pubmed
    ..The cholesterol transporter ABCG1 facilitates cholesterol efflux to HDL and is expressed in brain...
  2. Sankaranarayanan S, Oram J, Asztalos B, Vaughan A, Lund Katz S, Adorni M, et al. Effects of acceptor composition and mechanism of ABCG1-mediated cellular free cholesterol efflux. J Lipid Res. 2009;50:275-84 pubmed publisher
    Among the known mechanisms of reverse cholesterol transport (RCT), ATP binding cassette transporter G1 (ABCG1)-mediated free cholesterol (FC) transport is the most recent and least studied...
  3. Hirayama H, Kimura Y, Kioka N, Matsuo M, Ueda K. ATPase activity of human ABCG1 is stimulated by cholesterol and sphingomyelin. J Lipid Res. 2013;54:496-502 pubmed publisher
    ATP-binding cassette protein G1 (ABCG1) is important for the formation of HDL. However, the biochemical properties of ABCG1 have not been reported, and the mechanism of how ABCG1 is involved in HDL formation remains unclear...
  4. Kobayashi A, Takanezawa Y, Hirata T, Shimizu Y, Misasa K, Kioka N, et al. Efflux of sphingomyelin, cholesterol, and phosphatidylcholine by ABCG1. J Lipid Res. 2006;47:1791-802 pubmed
    ..b>ABCG1, one of the half-type ABC proteins, is thought to be involved in cholesterol homeostasis...
  5. Gao X, Gu H, Li G, Rye K, Zhang D. Identification of an amino acid residue in ATP-binding cassette transport G1 critical for mediating cholesterol efflux. Biochim Biophys Acta. 2012;1821:552-9 pubmed publisher
    The ATP-binding cassette transporter G1 (ABCG1) mediates free cholesterol efflux onto lipidated apolipoprotein A-I (apoA-I) and plays an important role in macrophage reverse cholesterol transport thereby reducing atherosclerosis...
  6. Klucken J, Büchler C, Orso E, Kaminski W, Porsch Ozcurumez M, Liebisch G, et al. ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport. Proc Natl Acad Sci U S A. 2000;97:817-22 pubmed
    ..We report here that the ATP-binding cassette (ABC) transporter ABCG1 (ABC8) is induced in monocyte-derived macrophages during cholesterol influx mediated by acetylated low-density ..
  7. Venkateswaran A, Repa J, Lobaccaro J, Bronson A, Mangelsdorf D, Edwards P. Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols. J Biol Chem. 2000;275:14700-7 pubmed
    ..The mRNA levels of ABC8, the murine homolog of the human white gene, were also induced when a murine macrophage cell line, RAW264...
  8. Vaughan A, Oram J. ABCG1 redistributes cell cholesterol to domains removable by high density lipoprotein but not by lipid-depleted apolipoproteins. J Biol Chem. 2005;280:30150-7 pubmed
    ATP binding cassette transporter G1 (ABCG1) mediates the transport of cholesterol from cells to high density lipoprotein (HDL) but not to lipid-depleted apolipoprotein A-I...
  9. Kennedy M, Barrera G, Nakamura K, Baldán A, Tarr P, Fishbein M, et al. ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation. Cell Metab. 2005;1:121-31 pubmed
    Here we demonstrate that the ABC transporter ABCG1 plays a critical role in lipid homeostasis by controlling both tissue lipid levels and the efflux of cellular cholesterol to HDL...

More Information

Publications103 found, 100 shown here

  1. Engel T, Kannenberg F, Fobker M, Nofer J, Bode G, Lueken A, et al. Expression of ATP binding cassette-transporter ABCG1 prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol. FEBS Lett. 2007;581:1673-80 pubmed
    ..In the current study, we investigated whether ABC transporter family member G1 (ABCG1) may be involved in oxysterol transport, since its gene expression is highly responsive to oxysterol loading...
  2. Li D, Zhang Y, Ma J, Ling W, Xia M. Adenosine monophosphate activated protein kinase regulates ABCG1-mediated oxysterol efflux from endothelial cells and protects against hypercholesterolemia-induced endothelial dysfunction. Arterioscler Thromb Vasc Biol. 2010;30:1354-62 pubmed publisher
    ..In this study, we examined whether the beneficial effects of AMPK on ECs are dependent on its involvement in cholesterol efflux and its impact on hypercholesterolemia-induced endothelial dysfunction...
  3. Cserepes J, Szentpetery Z, Seres L, Ozvegy Laczka C, Langmann T, Schmitz G, et al. Functional expression and characterization of the human ABCG1 and ABCG4 proteins: indications for heterodimerization. Biochem Biophys Res Commun. 2004;320:860-7 pubmed
    The closely related human ABC half-transporters, ABCG1 and ABCG4, have been suggested to play an important role in cellular lipid/sterol regulation but no experimental data for their expression or function are available...
  4. Wang N, Ranalletta M, Matsuura F, Peng F, Tall A. LXR-induced redistribution of ABCG1 to plasma membrane in macrophages enhances cholesterol mass efflux to HDL. Arterioscler Thromb Vasc Biol. 2006;26:1310-6 pubmed
    This study examines the ABCG1-mediated cholesterol efflux and intracellular cholesterol transport by studying the ABCG1 localization and function in macrophages.
  5. Sano O, Kobayashi A, Nagao K, Kumagai K, Kioka N, Hanada K, et al. Sphingomyelin-dependence of cholesterol efflux mediated by ABCG1. J Lipid Res. 2007;48:2377-84 pubmed
    b>ABCG1, one of the half-type ATP binding cassette (ABC) proteins, mediates the efflux of cholesterol to HDL and functions in the reverse cholesterol transport from peripheral cells to the liver...
  6. Seres L, Cserepes J, Elkind N, Torocsik D, Nagy L, Sarkadi B, et al. Functional ABCG1 expression induces apoptosis in macrophages and other cell types. Biochim Biophys Acta. 2008;1778:2378-87 pubmed publisher
    The expression of the ATP-binding cassette transporter ABCG1 is greatly increased in macrophages by cholesterol loading via the activation of the nuclear receptor LXR...
  7. Out R, Hoekstra M, Hildebrand R, Kruit J, Meurs I, Li Z, et al. Macrophage ABCG1 deletion disrupts lipid homeostasis in alveolar macrophages and moderately influences atherosclerotic lesion development in LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol. 2006;26:2295-300 pubmed
    b>ABCG1 has recently been identified as a facilitator of cellular cholesterol and phospholipid efflux to high-density lipoprotein (HDL)...
  8. Engel T, Bode G, Lueken A, Knop M, Kannenberg F, Nofer J, et al. Expression and functional characterization of ABCG1 splice variant ABCG1(666). FEBS Lett. 2006;580:4551-9 pubmed
    The ATP-binding cassette transporter ABCG1 mediates the transport of excess cholesterol from macrophages and other cell types to high density lipoprotein (HDL) but not to lipid-depleted apolipoprotein AI...
  9. Burgess B, Naus K, Chan J, Hirsch Reinshagen V, Tansley G, Matzke L, et al. Overexpression of human ABCG1 does not affect atherosclerosis in fat-fed ApoE-deficient mice. Arterioscler Thromb Vasc Biol. 2008;28:1731-7 pubmed publisher
    The purpose of this study was to evaluate the effects of whole body overexpression of human ABCG1 on atherosclerosis in apoE(-/-) mice.
  10. Favari E, Calabresi L, Adorni M, Jessup W, Simonelli S, Franceschini G, et al. Small discoidal pre-beta1 HDL particles are efficient acceptors of cell cholesterol via ABCA1 and ABCG1. Biochemistry. 2009;48:11067-74 pubmed publisher
    ..Cholesterol efflux to rHDL was evaluated in pathway-specific cell models for ABCA1-, ABCG1-, and SR-BI-mediated efflux. ABCA1-mediated efflux was efficiently promoted by the 7...
  11. Gelissen I, Harris M, Rye K, Quinn C, Brown A, Kockx M, et al. ABCA1 and ABCG1 synergize to mediate cholesterol export to apoA-I. Arterioscler Thromb Vasc Biol. 2006;26:534-40 pubmed
    To study the acceptor specificity for human ABCG1 (hABCG1)-mediated cholesterol efflux.
  12. Vaughan A, Oram J. ABCA1 and ABCG1 or ABCG4 act sequentially to remove cellular cholesterol and generate cholesterol-rich HDL. J Lipid Res. 2006;47:2433-43 pubmed
    ..the transport of cholesterol and phospholipids from cells to lipid-poor apolipoprotein A-I (apoA-I), whereas ABCG1 and ABCG4 mediate the transport of cholesterol from cells to lipidated lipoproteins...
  13. Mauldin J, Nagelin M, Wojcik A, Srinivasan S, Skaflen M, Ayers C, et al. Reduced expression of ATP-binding cassette transporter G1 increases cholesterol accumulation in macrophages of patients with type 2 diabetes mellitus. Circulation. 2008;117:2785-92 pubmed publisher
    ..The ATP-binding cassette (ABC) transporters ABCA1 and ABCG1 regulate macrophage cholesterol efflux and hence play a vital role in macrophage foam cell formation...
  14. Terasaka N, Westerterp M, Koetsveld J, Fernandez Hernando C, Yvan Charvet L, Wang N, et al. ATP-binding cassette transporter G1 and high-density lipoprotein promote endothelial NO synthesis through a decrease in the interaction of caveolin-1 and endothelial NO synthase. Arterioscler Thromb Vasc Biol. 2010;30:2219-25 pubmed publisher
    To investigate whether cholesterol efflux to high-density lipoprotein (HDL) via ATP-binding cassette transporter G1 (ABCG1) modulates the interaction of caveolin (Cav) 1 and endothelial NO synthase (eNOS).
  15. Xu Y, Wang W, Zhang L, Qi L, Li L, Chen L, et al. A polymorphism in the ABCG1 promoter is functionally associated with coronary artery disease in a Chinese Han population. Atherosclerosis. 2011;219:648-54 pubmed publisher
    In this study, we examine the association of single nucleotide polymorphisms (SNPs) of the human ATP binding cassette transporter G1 (ABCG1) gene with atherosclerotic coronary artery disease (CAD) in a Chinese Han population.
  16. Schou J, Frikke Schmidt R, Kardassis D, Thymiakou E, Nordestgaard B, Jensen G, et al. Genetic variation in ABCG1 and risk of myocardial infarction and ischemic heart disease. Arterioscler Thromb Vasc Biol. 2012;32:506-15 pubmed publisher
    ATP binding cassette transporter G1 (ABCG1) facilitates cholesterol efflux from macrophages to mature high-density lipoprotein particles...
  17. Xue J, Wei J, Dong X, Zhu C, Li Y, Song A, et al. ABCG1 deficiency promotes endothelial apoptosis by endoplasmic reticulum stress-dependent pathway. J Physiol Sci. 2013;63:435-44 pubmed publisher
    The present study was focused on whether ABCG1 deficiency was involved in endothelial apoptosis and its possible mechanism. Human umbilical artery endothelial cells were transfected with ABCG1 siRNA and/or ABCG1 expression plasmid...
  18. Gu H, Wang F, Zhang D. Caveolin-1 interacts with ATP binding cassette transporter G1 (ABCG1) and regulates ABCG1-mediated cholesterol efflux. Biochim Biophys Acta. 2014;1841:847-58 pubmed publisher
    ATP-binding cassette transporter G1 (ABCG1) plays an important role in macrophage reverse cholesterol transport in vivo by promoting cholesterol efflux onto lipidated apoA-I. However, the underlying mechanism is unclear...
  19. Ma C, Zhang W, Yang X, Liu Y, Liu L, Feng K, et al. Functional interplay between liver X receptor and AMP-activated protein kinase α inhibits atherosclerosis in apolipoprotein E-deficient mice - a new anti-atherogenic strategy. Br J Pharmacol. 2018;175:1486-1503 pubmed publisher
    ..their accumulation in arterial wall were inhibited by the co-treatment, which was accompanied by increased ABCA1/ABCG1 expression, reduced monocyte adhesion and apparent local proliferation of macrophages...
  20. George L, Mitra A, Thimraj T, Irmler M, Vishweswaraiah S, Lunding L, et al. Transcriptomic analysis comparing mouse strains with extreme total lung capacities identifies novel candidate genes for pulmonary function. Respir Res. 2017;18:152 pubmed publisher
    ..genes identified using the expression-QTL strategy include: ATP-binding cassette, sub-family G (WHITE), member 1 (Abcg1), formyl peptide receptor 1 (Fpr1), gamma-aminobutyric acid (GABA) B receptor, 1 (Gabbr1); histocompatibility 2 ..
  21. Pang T, Wang J, Benicky J, Sánchez Lemus E, Saavedra J. Telmisartan directly ameliorates the neuronal inflammatory response to IL-1β partly through the JNK/c-Jun and NADPH oxidase pathways. J Neuroinflammation. 2012;9:102 pubmed publisher
    ..with the antagonists GW9662 and T0070907, the agonist pioglitazone and the expression of PPARγ target genes ABCG1 and CD36. We found that SK-N-SH neuroblasts expressed AT1 but not AT2 receptor mRNA...
  22. Liao Y, Chen T, Lee T, Wang H, Wang C, Liao L, et al. Glycine N-methyltransferase deficiency affects Niemann-Pick type C2 protein stability and regulates hepatic cholesterol homeostasis. Mol Med. 2012;18:412-22 pubmed publisher
    ..type C1 protein [NPC1] and Niemann-Pick type C2 protein [NPC2]) and excretion (ATP-binding cassette G1 [ABCG1]) were downregulated in Gnmt(-/-) mice...
  23. Sun Y, Kopp S, Strutz J, Gali C, Zandl Lang M, Fanaee Danesh E, et al. Gestational diabetes mellitus modulates cholesterol homeostasis in human fetoplacental endothelium. Biochim Biophys Acta Mol Cell Biol Lipids. 2018;1863:968-979 pubmed publisher
    ..TO901319, 7-ketocholesterol, or 7?-hydroxycholesterol upregulated ATP-binding cassette transporters (ABC)A1 and ABCG1 expression, accompanied by increased cellular cholesterol efflux...
  24. Zhao Z, Zhang M, Chen L, Gong D, Xia X, Yu X, et al. Heat shock protein 70 accelerates atherosclerosis by downregulating the expression of ABCA1 and ABCG1 through the JNK/Elk-1 pathway. Biochim Biophys Acta Mol Cell Biol Lipids. 2018;1863:806-822 pubmed publisher
    ..chromatin immunoprecipitation were performed to analyze the effect of Elk-1 on the promoter activity of ABCA1 and ABCG1; [3H] labeled cholesterol was used to assess the capacity of cholesterol efflux and reverse cholesterol ..
  25. Baldán A, Gomes A, Ping P, Edwards P. Loss of ABCG1 results in chronic pulmonary inflammation. J Immunol. 2008;180:3560-8 pubmed
    b>ABCG1, a member of the ATP-binding cassette transporter superfamily, is highly expressed in multiple cells of the lung...
  26. Westerterp M, Gourion Arsiquaud S, Murphy A, Shih A, Cremers S, Levine R, et al. Regulation of hematopoietic stem and progenitor cell mobilization by cholesterol efflux pathways. Cell Stem Cell. 2012;11:195-206 pubmed publisher
    ..with defects in cholesterol efflux pathways due to deficiencies of the ATP binding cassette transporters ABCA1 and ABCG1 displayed a dramatic increase in HSPC mobilization and extramedullary hematopoiesis...
  27. Lin Y, Liu P, Adhikari N, Hall J, Wei L. RIP140 contributes to foam cell formation and atherosclerosis by regulating cholesterol homeostasis in macrophages. J Mol Cell Cardiol. 2015;79:287-94 pubmed publisher
    ..genes, A TP-binding membrane cassette transporter A-1 (ABCA1) and ATP-binding membrane cassette transporter G-1 (ABCG1)...
  28. Luo T, Hu J, Xi D, Xiong H, He W, Liu J, et al. Lck Inhibits Heat Shock Protein 65-Mediated Reverse Cholesterol Transport in T Cells. J Immunol. 2016;197:3861-3870 pubmed
    ..HSP65-mediated inhibition of RCT was assessed by evaluating ABCA1, ABCG1, SR-BI, PPAR-?, and liver X receptor-? expression...
  29. Jiang T, Ren K, Chen Q, Li H, Yao R, Hu H, et al. Leonurine Prevents Atherosclerosis Via Promoting the Expression of ABCA1 and ABCG1 in a Ppar?/Lxr? Signaling Pathway-Dependent Manner. Cell Physiol Biochem. 2017;43:1703-1717 pubmed publisher
    ..This study was designed to investigate the effects of leonurine on cholesterol efflux from THP-1 macrophage-derived foam cells and development of atherosclerotic lesions in apoE-/- mice, and further determine the potential mechanisms...
  30. Tang Y, Wu H, Shao B, Wang Y, Liu C, Guo M. Celosins inhibit atherosclerosis in ApoE-/- mice and promote autophagy flow. J Ethnopharmacol. 2018;215:74-82 pubmed publisher
    ..The mRNA expression of CD36, SR-A1, ABCA1 and ABCG1 were determined by Real-Time PCR method. The expressions of LC3 and beclin 1 were measured using Western blot...
  31. Cavelier C, Lorenzi I, Rohrer L, von Eckardstein A. Lipid efflux by the ATP-binding cassette transporters ABCA1 and ABCG1. Biochim Biophys Acta. 2006;1761:655-66 pubmed
    ..The ATP-binding cassette transporters ABCA1 and ABCG1 play a pivotal role in this process by effluxing lipids from foam cells to apoA-I and HDL, respectively...
  32. Zhou H, Tan K, Shiu S, Wong Y. Determinants of leukocyte adenosine triphosphate-binding cassette transporter G1 gene expression in type 2 diabetes mellitus. Metabolism. 2008;57:1135-40 pubmed publisher
    ..is regulated by cholesterol transporters including adenosine triphosphate-binding cassette transporter A1 (ABCA1), ABCG1, and scavenger receptor class B type I (SR-BI)...
  33. Armstrong A, Gebre A, Parks J, Hedrick C. ATP-binding cassette transporter G1 negatively regulates thymocyte and peripheral lymphocyte proliferation. J Immunol. 2010;184:173-83 pubmed publisher
    ..We demonstrate that ATP-binding cassette transporter G1 (ABCG1) regulates cholesterol homeostasis in thymocytes and peripheral CD4 T cells...
  34. Yang Y, Thyagarajan N, Coady B, Brown R. Cholesterol efflux from THP-1 macrophages is impaired by the fatty acid component from lipoprotein hydrolysis by lipoprotein lipase. Biochem Biophys Res Commun. 2014;451:632-6 pubmed publisher
    ..reduced transcript levels for the cholesterol transporters ATP binding cassette transporter A1 (ABCA1), ABCG1, and scavenger receptor BI...
  35. Baldán A, Gonen A, Choung C, Que X, Marquart T, Hernandez I, et al. ABCG1 is required for pulmonary B-1 B cell and natural antibody homeostasis. J Immunol. 2014;193:5637-48 pubmed publisher
    ..Mice lacking the ATP-binding cassette transporter G1 (ABCG1) develop chronic inflammation in the lungs, which is associated with the lipid accumulation (cholesterol, ..
  36. Miroshnikova V, Demina E, MaÄ­orov N, Davydenko V, Kur ianov P, Vavilov V, et al. [ABCG1 transporter gene expression in peripheral blood mononuclear cells of patients with atherosclerosis]. Tsitologiia. 2014;56:234-40 pubmed
    Accumulation of cholesterol in arterial wall macrophages is a main hallmark of atherosclerosis. The ABCG1 transporter mediates cholesterol efflux to high density lipoproteins (HDL) and plays an important role in macrophage foam cell ..
  37. Uehara Y, Miura S, von Eckardstein A, Abe S, Fujii A, Matsuo Y, et al. Unsaturated fatty acids suppress the expression of the ATP-binding cassette transporter G1 (ABCG1) and ABCA1 genes via an LXR/RXR responsive element. Atherosclerosis. 2007;191:11-21 pubmed
    ..fatty acids significantly suppress the stimulatory effects of oxysterols and retinoids on the expression of ABCG1 mRNA and protein and the activity of the wild-type human ABCG1 promoter as well as ABCA1...
  38. Baldán A, Pei L, Lee R, Tarr P, Tangirala R, Weinstein M, et al. Impaired development of atherosclerosis in hyperlipidemic Ldlr-/- and ApoE-/- mice transplanted with Abcg1-/- bone marrow. Arterioscler Thromb Vasc Biol. 2006;26:2301-7 pubmed
    The lungs of Abcg1-/- mice accumulate macrophage foam cells that contain high levels of unesterified and esterified cholesterol, consistent with a role for ABCG1 in facilitating the efflux of cholesterol from macrophages to high-density ..
  39. Boadu E, Choi H, Lee D, Waddington E, Chan T, Asztalos B, et al. Correction of apolipoprotein A-I-mediated lipid efflux and high density lipoprotein particle formation in human Niemann-Pick type C disease fibroblasts. J Biol Chem. 2006;281:37081-90 pubmed
    ..b>ABCG1, another LXR target gene involved in cholesterol efflux to HDL, also showed diminished expression in NPC1(-/-) ..
  40. Field F, Watt K, Mathur S. TNF-alpha decreases ABCA1 expression and attenuates HDL cholesterol efflux in the human intestinal cell line Caco-2. J Lipid Res. 2010;51:1407-15 pubmed publisher
    ..expression without attenuating the expression of LXR-alpha, LXR-beta, and most other LXR target genes, such as ABCG1, FAS, ABCG8, scavenger receptor-B1 (SR-B1), and apoC1...
  41. Ono K, Horie T, Nishino T, Baba O, Kuwabara Y, Kimura T. MicroRNAs and High-Density Lipoprotein Cholesterol Metabolism. Int Heart J. 2015;56:365-71 pubmed publisher
    ..of genes associated with high-density lipoprotein (HDL) cholesterol (HDL-C) metabolism, including ABCA1, ABCG1, and scavenger receptor class B, type I...
  42. Zhu W, Wang S, Liu Z, Cao Y, Wang F, Wang J, et al. Gly[14]-humanin inhibits ox-LDL uptake and stimulates cholesterol efflux in macrophage-derived foam cells. Biochem Biophys Res Commun. 2017;482:93-99 pubmed publisher
    ..of CD36 and LOX-1, which mediate ox-LDL endocytosis, but also ATP-binding cassette (ABC) transporter A1 and ABCG1, which mediate ox-LDL exflux...
  43. Hedman Ã, Mendelson M, Marioni R, Gustafsson S, Joehanes R, Irvin M, et al. Epigenetic Patterns in Blood Associated With Lipid Traits Predict Incident Coronary Heart Disease Events and Are Enriched for Results From Genome-Wide Association Studies. Circ Cardiovasc Genet. 2017;10: pubmed publisher
    ..1E-26 and 9.3E-19) was associated with cis-expression of a reverse cholesterol transporter (ABCG1; P=7.2E-28) and incident cardiovascular disease events (hazard ratio per SD increment, 1...
  44. Carter A, Letronne F, Fitz N, Mounier A, Wolfe C, Nam K, et al. Liver X receptor agonist treatment significantly affects phenotype and transcriptome of APOE3 and APOE4 Abca1 haplo-deficient mice. PLoS ONE. 2017;12:e0172161 pubmed publisher
    ..APOE isoform, T0 treatment increased mRNA level of genes known to affect brain APOE lipidation such as Abca1 and Abcg1. In both APP/E3/Abca1+/- and APP/E4/Abca1+/- mice, the application of LXR agonist significantly increased ABCA1 ..
  45. Brewer H, Santamarina Fojo S. New insights into the role of the adenosine triphosphate-binding cassette transporters in high-density lipoprotein metabolism and reverse cholesterol transport. Am J Cardiol. 2003;91:3E-11E pubmed
    Four adenosine triphosphate-binding cassette (ABC) transporters-ABCA1, ABCG1, ABCG5, and ABCG8-have been identified and shown to modulate cholesterol and lipoprotein metabolism...
  46. Malur A, Baker A, Mccoy A, Wells G, Barna B, Kavuru M, et al. Restoration of PPAR? reverses lipid accumulation in alveolar macrophages of GM-CSF knockout mice. Am J Physiol Lung Cell Mol Physiol. 2011;300:L73-80 pubmed publisher
    ..We previously reported decreased PPAR? and ATP-binding cassette transporter G1 (ABCG1) levels in alveolar macrophages from PAP patients and GM-CSF knockout (KO) mice, suggesting PPAR? and ABCG1 ..
  47. Davidson M. Therapies targeting exogenous cholesterol uptake: new insights and controversies. Curr Atheroscler Rep. 2011;13:95-100 pubmed publisher
    ..by intestinal nuclear transcription factors such as LXR that affect sterol transporters NPC1L1, ABCG5/G8, and ABCG1, and enzymes such as ACAT-2...
  48. Lucero D, Sviridov D, Svidirov D, Freeman L, López G, Fassio E, et al. Increased cholesterol efflux capacity in metabolic syndrome: Relation with qualitative alterations in HDL and LCAT. Atherosclerosis. 2015;242:236-42 pubmed publisher
    ..ability of apoB-depleted serum to accept cholesterol from cholesterol-loaded BHK cells expressing either ABCA1 or ABCG1. Additionally we determined: lipid profile, HDL sub-fractions (NMR) and LCAT mass (ELISA). Isolated HDL (δ:1...
  49. Wang X, Collins H, Ranalletta M, Fuki I, Billheimer J, Rothblat G, et al. Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo. J Clin Invest. 2007;117:2216-24 pubmed
    Macrophage ATP-binding cassette transporter A1 (ABCA1), scavenger receptor class B type I (SR-BI), and ABCG1 have been shown to promote cholesterol efflux to extracellular acceptors in vitro and influence atherosclerosis in mice, but ..
  50. Draper D, Gowdy K, Madenspacher J, Wilson R, Whitehead G, Nakano H, et al. ATP binding cassette transporter G1 deletion induces IL-17-dependent dysregulation of pulmonary adaptive immunity. J Immunol. 2012;188:5327-36 pubmed publisher
    Mice with genetic deletion of the cholesterol transporter ATP binding cassette G1 (ABCG1) have pulmonary lipidosis and enhanced innate immune responses in the airway...
  51. Bloise E, Ortiga Carvalho T, Reis F, Lye S, Gibb W, Matthews S. ATP-binding cassette transporters in reproduction: a new frontier. Hum Reprod Update. 2016;22:164-81 pubmed publisher
    ..cancer-related protein, the multidrug resistance proteins 1 through 5 and the cholesterol transporters ABCA1 and ABCG1. The ABC transporters have various roles across multiple reproductive tissues...
  52. Canfrán Duque A, Rotllan N, Zhang X, Fernández Fuertes M, Ramírez Hidalgo C, Araldi E, et al. Macrophage deficiency of miR-21 promotes apoptosis, plaque necrosis, and vascular inflammation during atherogenesis. EMBO Mol Med. 2017;9:1244-1262 pubmed publisher
    ..Both pathways enhance macrophage apoptosis and promote the post-translational degradation of ABCG1, a transporter that regulates cholesterol efflux in macrophages...
  53. O Connell B, Denis M, Genest J. Cellular physiology of cholesterol efflux in vascular endothelial cells. Circulation. 2004;110:2881-8 pubmed
    ..Of the cells that compose the atherosclerotic plaque, vascular endothelial cells are the most resistant to cholesterol accumulation. Cholesterol efflux pathways may play an important role in endothelial cholesterol homeostasis...
  54. Abildayeva K, Jansen P, Hirsch Reinshagen V, Bloks V, Bakker A, Ramaekers F, et al. 24(S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux. J Biol Chem. 2006;281:12799-808 pubmed
    ..cholesterol efflux from astrocytoma cells may be controlled by the ATP binding cassette transporters ABCA1 and ABCG1, since their expression was also up-regulated by both compounds...
  55. Wang N, Yvan Charvet L, Lutjohann D, Mulder M, Vanmierlo T, Kim T, et al. ATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain. FASEB J. 2008;22:1073-82 pubmed
    ..Overexpression of ATP-binding cassette transporters G1 (Abcg1) and G4 (Abcg4) can promote cellular cholesterol efflux to high-density lipoprotein (HDL), but the in vivo ..
  56. Wang Y, Liu H, Ready N, Su L, Wei Y, Christiani D, et al. Genetic variants in ABCG1 are associated with survival of nonsmall-cell lung cancer patients. Int J Cancer. 2016;138:2592-601 pubmed publisher
    ..1 in the discovery dataset. Subsequently, we confirmed six SNPs, which were putative functional, in ABCG1 of the ATP-binding cassette transporter family in the replication dataset...
  57. Zhao S, Li J, Wang L, Wu X. Pomegranate peel polyphenols inhibit lipid accumulation and enhance cholesterol efflux in raw264.7 macrophages. Food Funct. 2016;7:3201-10 pubmed publisher
    ..In addition, pomegranate peel polyphenols promoted apoA-1-mediated macrophage cholesterol efflux by up-regulating ABCA1 and LXRα at the mRNA and protein levels, independently of ABCG1 and PPARγ.
  58. He J, Zhang G, Pang Q, Yu C, Xiong J, Zhu J, et al. SIRT6 reduces macrophage foam cell formation by inducing autophagy and cholesterol efflux under ox-LDL condition. FEBS J. 2017;284:1324-1337 pubmed publisher
    ..indicated that SIRT6 overexpression in foam cells promoted cholesterol efflux, increased the levels of ABCA1 and ABCG1, and reduced miR-33 levels...
  59. Wojcik A, Skaflen M, Srinivasan S, Hedrick C. A critical role for ABCG1 in macrophage inflammation and lung homeostasis. J Immunol. 2008;180:4273-82 pubmed
    ATP-binding cassette transporter G1 (ABCG1) effluxes cholesterol from macrophages and plays an important role in pulmonary lipid homeostasis...
  60. Suzuki K, Kawakami Y, Yamauchi K. Impact of TLR 2, TLR 4-activation on the Expression of ABCA1 and ABCG1 in Raw Cells. Ann Clin Lab Sci. 2017;47:436-446 pubmed
    ..effects of TLR2- and TLR4-activation on the expression of the ATP-binding cassette (ABC) transporters ABCA1 and ABCG1 in a mouse macrophage cell line, Raw 264.7...
  61. Kim W, Chan S, Hill A, Guillemin G, Garner B. Impact of 27-hydroxycholesterol on amyloid-beta peptide production and ATP-binding cassette transporter expression in primary human neurons. J Alzheimers Dis. 2009;16:121-31 pubmed publisher
    ..alpha-, beta- or gamma-secretase activity but does upregulate the liver X receptor (LXR) responsive genes ABCA1, ABCG1 and APOE...
  62. Pommier A, Alves G, Viennois E, Bernard S, Communal Y, Sion B, et al. Liver X Receptor activation downregulates AKT survival signaling in lipid rafts and induces apoptosis of prostate cancer cells. Oncogene. 2010;29:2712-23 pubmed publisher
    ..The decrease in tumor cholesterol content resulted from the upregulation of ABCG1 and the subsequent increase in reverse cholesterol transport...
  63. Jiang Y, Lu B, Tarling E, Kim P, Man M, Crumrine D, et al. Regulation of ABCG1 expression in human keratinocytes and murine epidermis. J Lipid Res. 2010;51:3185-95 pubmed publisher
    b>ABCG1, a member of the ATP binding cassette superfamily, facilitates the efflux of cholesterol from cells to HDL...
  64. Genvigir F, Rodrigues A, Cerda A, Hirata M, Curi R, Hirata R. ABCA1 and ABCG1 expressions are regulated by statins and ezetimibe in Caco-2 cells. Drug Metabol Drug Interact. 2011;26:33-6 pubmed publisher
    ..We hypothesized that these drugs could modulate the expression of intestinal ABCA1 and ABCG1, two genes involved in HDL metabolism.
  65. Frisdal E, Le Lay S, Hooton H, Poupel L, Olivier M, Alili R, et al. Adipocyte ATP-binding cassette G1 promotes triglyceride storage, fat mass growth, and human obesity. Diabetes. 2015;64:840-55 pubmed publisher
    The role of the ATP-binding cassette G1 (ABCG1) transporter in human pathophysiology is still largely unknown...
  66. Baral B, Kovalchuk A, Asiegbu F. Genome organisation and expression profiling of ABC protein-encoding genes in Heterobasidion annosum s.l. complex. Fungal Biol. 2016;120:376-84 pubmed publisher
    ..Several ABC transporters were up-regulated during growth on pine wood. The ABC-transporter encoding gene ABCG1.1 was induced both during growth of H. annosum on pine wood and upon exposure to monoterpenes...
  67. Edgel K, McMillen T, Wei H, Pamir N, Houston B, Caldwell M, et al. Obesity and weight loss result in increased adipose tissue ABCG1 expression in db/db mice. Biochim Biophys Acta. 2012;1821:425-34 pubmed publisher
    ..The major finding was a marked elevation in epididymal adipose ABCG1 mRNA levels with obesity and CR (6-fold and 16-fold, respectively) over that seen for lean wild-type mice...
  68. Meurs I, Lammers B, Zhao Y, Out R, Hildebrand R, Hoekstra M, et al. The effect of ABCG1 deficiency on atherosclerotic lesion development in LDL receptor knockout mice depends on the stage of atherogenesis. Atherosclerosis. 2012;221:41-7 pubmed publisher
    As ABCG1 plays a role in cholesterol efflux, macrophage ABCG1 expression has been suggested to protect against atherosclerosis. However, we and others observed varying effects of ABCG1 deficiency on atherosclerotic lesion size...
  69. Chellan B, Yan L, Sontag T, Reardon C, HOFMANN BOWMAN M. IL-22 is induced by S100/calgranulin and impairs cholesterol efflux in macrophages by downregulating ABCG1. J Lipid Res. 2014;55:443-54 pubmed publisher
    ..in myeloid cells [human bacterial artificial chromosome (hBAC)/S100] have increased lipid content and reduced ABCG1 expression and [(3)H]cholesterol efflux compared with WT littermates...
  70. Xue S, Wang J, Zhang X, Shi Y, Li B, Bao Q, et al. Endothelial ATP-binding cassette G1 in mouse endothelium protects against hemodynamic-induced atherosclerosis. Biochem Biophys Res Commun. 2016;477:247-54 pubmed publisher
    ..ATP-binding cassette G1 (ABCG1) is a crucial factor maintaining sterol and lipid homeostasis by transporting cholesterol efflux to high-density ..
  71. de Aguiar Vallim T, Lee E, Merriott D, Goulbourne C, Cheng J, Cheng A, et al. ABCG1 regulates pulmonary surfactant metabolism in mice and men. J Lipid Res. 2017;58:941-954 pubmed publisher
    ..Clearance of surfactant is dependent upon T2 cells and macrophages. ABCG1 is highly expressed in both T2 cells and macrophages...
  72. He H, Yuan Q, Bie J, Wallace R, Yannie P, Wang J, et al. Development of mannose functionalized dendrimeric nanoparticles for targeted delivery to macrophages: use of this platform to modulate atherosclerosis. Transl Res. 2018;193:13-30 pubmed publisher
    ..was effectively taken up by macrophages (and not by hepatocytes), increased expression of LXR target genes (ABCA1/ABCG1), and enhanced cholesterol efflux...
  73. Costet P, Lalanne F, Gerbod Giannone M, Molina J, Fu X, Lund E, et al. Retinoic acid receptor-mediated induction of ABCA1 in macrophages. Mol Cell Biol. 2003;23:7756-66 pubmed
    ..experiments with ATRA in mouse primary macrophages showed that other LXR target genes were weakly induced (ABCG1 and SREBP-1c) or not induced (apoE and LXRalpha)...
  74. Kim G, Park K, Yeom S, Lee K, Kim G, Ko J, et al. Characterization of ASC-2 as an antiatherogenic transcriptional coactivator of liver X receptors in macrophages. Mol Endocrinol. 2009;23:966-74 pubmed publisher
    ..DN2 reduced LXR ligand-dependent increases in the levels of ABCA1, ABCG1, and apolipoprotein E (apoE) transcripts as well as the activity of luciferase reporters driven by the LXR ..
  75. Abellan R, Mansego M, Martinez Hervas S, Martin Escudero J, Carmena R, Real J, et al. Association of selected ABC gene family single nucleotide polymorphisms with postprandial lipoproteins: results from the population-based Hortega study. Atherosclerosis. 2010;211:203-9 pubmed publisher
    The aim of the study was to determine the influence of twenty single nucleotide polymorphisms (SNPs) of the ABCA1, ABCG1, ABCG5 and ABCG8 genes on the plasmatic concentrations of total cholesterol (TC), HDL and LDL cholesterol (HDLc, ..
  76. Okada Y, Ueyama K, Nishikawa J, Semma M, Ichikawa A. Effect of 6-O-?-maltosyl-? cyclodextrin and its cholesterol inclusion complex on cellular cholesterol levels and ABCA1 and ABCG1 expression in mouse mastocytoma P-815 cells. Carbohydr Res. 2012;357:68-74 pubmed publisher
    ..P-815 cells have been confirmed to express ATP-binding cassette (ABC) transporters, ABCA1, ABCG1, and P-glycoprotein (P-gp), by Western blot and mRNA analysis...
  77. Mauerer R, Ebert S, Langmann T. High glucose, unsaturated and saturated fatty acids differentially regulate expression of ATP-binding cassette transporters ABCA1 and ABCG1 in human macrophages. Exp Mol Med. 2009;41:126-32 pubmed
    The ATP-binding cassette transporters ABCA1 and ABCG1 are highly expressed in macrophage-derived foam cells and promote reverse cholesterol efflux via biogenesis of high-density lipoproteins...
  78. Kerr I, Haider A, Gelissen I. The ABCG family of membrane-associated transporters: you don't have to be big to be mighty. Br J Pharmacol. 2011;164:1767-79 pubmed publisher
    ..The principal substrates for at least four of the ABCG proteins are endogenous and dietary lipids, with ABCG1 implicated in particular in the export of cholesterol, and ABCG5 and G8 forming a functional heterodimer ..
  79. Sag D, Cekic C, Wu R, Linden J, Hedrick C. The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity. Nat Commun. 2015;6:6354 pubmed publisher
    ATP-binding cassette transporter G1 (ABCG1) promotes cholesterol efflux from cells and regulates intracellular cholesterol homeostasis. Here we demonstrate a role of ABCG1 as a mediator of tumour immunity...
  80. Mostafa A, Hamdy N, El Mesallamy H, Abdel Rahman S. Glucagon-like peptide 1 (GLP-1)-based therapy upregulates LXR-ABCA1/ABCG1 cascade in adipocytes. Biochem Biophys Res Commun. 2015;468:900-5 pubmed publisher
    ..Members of the ATP-binding cassette (ABC) transporters, including ABCA1 and ABCG1, play essential roles in reverse cholesterol transport and in high density lipoprotein (HDL) formation...
  81. Schmitz G, Langmann T, Heimerl S. Role of ABCG1 and other ABCG family members in lipid metabolism. J Lipid Res. 2001;42:1513-20 pubmed
    ..ATP-binding cassette transporter A1 (ABCA1) molecule, ABC transporters belonging to the ABCG (White) subfamily (ABCG1, ABCG5, and ABCG8) have been shown to be critically involved in the regulation of lipid-trafficking mechanisms in ..
  82. Morales C, Marat A, Ni X, Yu Y, Oko R, Smith B, et al. ATP-binding cassette transporters ABCA1, ABCA7, and ABCG1 in mouse spermatozoa. Biochem Biophys Res Commun. 2008;376:472-7 pubmed publisher
    ..transporters are members of the ATP-binding cassette (ABC) transporter superfamily including ABCA1, ABCA7, ABCG1 and ABCG4, which have all been implicated in the transport of sterols and phospholipids to apolipoproteins and HDL...
  83. Schmitz G, Grandl M. Endolysosomal phospholipidosis and cytosolic lipid droplet storage and release in macrophages. Biochim Biophys Acta. 2009;1791:524-39 pubmed publisher
    ..atherogenic lipoprotein modifications, and their relation to the adapter protein 3 (AP-3) dependent ABCA1 and ABCG1 cellular lipid efflux pathways...
  84. Katz A, Udata C, Ott E, Hickey L, Burczynski M, Burghart P, et al. Safety, pharmacokinetics, and pharmacodynamics of single doses of LXR-623, a novel liver X-receptor agonist, in healthy participants. J Clin Pharmacol. 2009;49:643-9 pubmed publisher
    ..via the upregulation of cholesterol transporters such as the adenosine triphosphate-binding cassettes ABCA1 and ABCG1 could therefore inhibit the progression of atherosclerosis...
  85. Ishibashi Y, Matsui T, Takeuchi M, Yamagishi S. Rosuvastatin blocks advanced glycation end products-elicited reduction of macrophage cholesterol efflux by suppressing NADPH oxidase activity via inhibition of geranylgeranylation of Rac-1. Horm Metab Res. 2011;43:619-24 pubmed publisher
    Adenosine triphosphate-binding membrane cassette transporter A1 (ABCA1) and ABCG1 play a crucial role in macrophage cholesterol efflux, which is a novel therapeutic target for atherosclerosis...
  86. Ito T. Physiological function of ABCG1. Drug News Perspect. 2003;16:490-2 pubmed
    ..b>ABCG1 is an ABC half transporter that facilitates efflux excess cholesterol from macrophages...
  87. Orlowski S, Comera C, Tercé F, Collet X. Lipid rafts: dream or reality for cholesterol transporters?. Eur Biophys J. 2007;36:869-85 pubmed
    ..believed to mediate for instance the intestinal absorption of cholesterol, that are SR-BI, NPC1L1, ABCA1, ABCG1, ABCG5/G8 and even P-glycoprotein, all present privileged functional relationships with membrane cholesterol-..
  88. Huang X, Yu T, Li X, Cao Y, Li X, Liu B, et al. ABCB6, ABCB1 and ABCG1 genetic polymorphisms and antidepressant response of SSRIs in Chinese depressive patients. Pharmacogenomics. 2013;14:1723-30 pubmed publisher
    ..ATP-binding cassette proteins are responsible for the membrane transport of various molecules including antidepressive drugs. We investigated whether SNPs in ABCB6, ABCB1 and ABCG1 were associated with the treatment response of SSRIs.
  89. Olivier M, BottG R, Frisdal E, Nowick M, Plengpanich W, Desmarchelier C, et al. ABCG1 is involved in vitamin E efflux. Biochim Biophys Acta. 2014;1841:1741-51 pubmed
    ..aim was to investigate the possible participation of another cholesterol transporter in cellular vitamin E efflux: ABCG1. In Abcgl-deficient mice, vitamin E concentration was reduced in plasma lipoproteins whereas most tissues ..
  90. Catalano G, Duchene E, Julia Z, Le Goff W, Bruckert E, Chapman M, et al. Cellular SR-BI and ABCA1-mediated cholesterol efflux are gender-specific in healthy subjects. J Lipid Res. 2008;49:635-43 pubmed
    ..subspecies on cellular free cholesterol efflux through the scavenger receptor class B type I (SR-BI), ABCA1, and ABCG1 pathways...
  91. Lukasova M, Malaval C, Gille A, Kero J, Offermanns S. Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells. J Clin Invest. 2011;121:1163-73 pubmed publisher
    ..WT mice, but not from GPR109A-deficient animals, nicotinic acid induced expression of the cholesterol transporter ABCG1 and promoted cholesterol efflux...
  92. Schou J, Tybjærg Hansen A, Møller H, Nordestgaard B, Frikke Schmidt R. ABC transporter genes and risk of type 2 diabetes: a study of 40,000 individuals from the general population. Diabetes Care. 2012;35:2600-6 pubmed publisher
    ..of intracellular cholesterol content are the ATP-binding cassette (ABC) transporters A1 (ABCA1) and -G1 (ABCG1)...