ABCA2

Summary

Gene Symbol: ABCA2
Description: ATP binding cassette subfamily A member 2
Alias: ABC2, ATP-binding cassette sub-family A member 2, ATP-binding cassette 2, ATP-binding cassette transporter 2, ATP-binding cassette, sub-family A (ABC1), member 2, ATP-binding cassette, sub-family A, member 2
Species: human
Products:     ABCA2

Top Publications

  1. Kaminski W, Piehler A, Püllmann K, Porsch Ozcurumez M, Duong C, Bared G, et al. Complete coding sequence, promoter region, and genomic structure of the human ABCA2 gene and evidence for sterol-dependent regulation in macrophages. Biochem Biophys Res Commun. 2001;281:249-58 pubmed
    ..Here we report the complete cDNA and the genomic organization of ABCA2, another member of the human ABC A transporter subfamily. The ABCA2 coding region is 7...
  2. Ile K, Davis W, Boyd J, Soulika A, Tew K. Identification of a novel first exon of the human ABCA2 transporter gene encoding a unique N-terminus. Biochim Biophys Acta. 2004;1678:22-32 pubmed
    The human ABCA2 transporter is a member of a large family of ATP-binding proteins that transport a variety of molecules across biological membranes...
  3. Mack J, Beljanski V, Soulika A, Townsend D, Brown C, Davis W, et al. "Skittish" Abca2 knockout mice display tremor, hyperactivity, and abnormal myelin ultrastructure in the central nervous system. Mol Cell Biol. 2007;27:44-53 pubmed
    The ATP-binding cassette transporter 2 (ABCA2) is an endolysosomal protein most highly expressed in the central and peripheral nervous system tissues and macrophages...
  4. Hu W, Lin X, Zhang H, Zhao N. ATP Binding Cassette Subfamily A Member 2 (ABCA2) Expression and Methylation are Associated with Alzheimer's Disease. Med Sci Monit. 2017;23:5851-5861 pubmed
    BACKGROUND ABCA2 has been genetically linked to Alzheimer's disease (AD) risk, but its mRNA expression and epigenetics in AD have not been investigated...
  5. Adams M, Dubnick M, Kerlavage A, Moreno R, Kelley J, Utterback T, et al. Sequence identification of 2,375 human brain genes. Nature. 1992;355:632-4 pubmed
    ..These data represent an approximate doubling of the number of human genes identified by DNA sequencing and may represent as many as 5% of the genes in the human genome. ..
  6. Soichi O, Masanori N, Hideo T, Kazunori A, Nobuya I, Jun ichi K. Clinical significance of ABCA2' a possible molecular marker for oligodendrogliomas. Neurosurgery. 2007;60:707-14; discussion 714 pubmed
    b>ABCA2 is a member of the adenosine triphosphate-binding cassette transporter superfamily and is proposed to exert critical functions in the transmembrane transport of endogenous lipids such as myelin...
  7. Davis W. The ATP-binding cassette transporter-2 (ABCA2) increases endogenous amyloid precursor protein expression and Aβ fragment generation. Curr Alzheimer Res. 2010;7:566-77 pubmed
    The ATP binding cassette transporter-2 (ABCA2) has been genetically linked to Alzheimer's disease but the molecular mechanisms are unknown...
  8. Mack J, Helke K, Normand G, Green C, Townsend D, Tew K. ABCA2 transporter deficiency reduces incidence of TRAMP prostate tumor metastasis and cellular chemotactic migration. Cancer Lett. 2011;300:154-61 pubmed publisher
    In order to study the effects of ATP-binding cassette transporter 2 (ABCA2) deficiency on the progression of prostate cancer, congenic Abca2 knockout (KO) mice were crossed to the transgenic adenocarcinoma of the mouse prostate (TRAMP) ..
  9. Shawahna R, Uchida Y, Declèves X, Ohtsuki S, Yousif S, Dauchy S, et al. Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels. Mol Pharm. 2011;8:1332-41 pubmed publisher
    ..SLC2A1/GLUT1, SLC1A3/EAAT1, and SLC1A2/EAAT2 were the main SLC proteins whereas ABCG2/BCRP, ABCB1/MDR1, ABCA2 and ABCA8 were the main ABC quantified in isolated brain microvessels; ABCG2/BCRP was 1...
  10. Latif H, Sahin M, Tarasova J, Tarasova Y, Portnoy V, Nogales J, et al. Adaptive Evolution of Thermotoga maritima Reveals Plasticity of the ABC Transporter Network. Appl Environ Microbiol. 2015;81:5477-85 pubmed publisher
    ..Analysis of the ABC2 uptake porter families for carbohydrate and peptide transport revealed that the solute binding protein, often among ..

Detail Information

Publications59

  1. Kaminski W, Piehler A, Püllmann K, Porsch Ozcurumez M, Duong C, Bared G, et al. Complete coding sequence, promoter region, and genomic structure of the human ABCA2 gene and evidence for sterol-dependent regulation in macrophages. Biochem Biophys Res Commun. 2001;281:249-58 pubmed
    ..Here we report the complete cDNA and the genomic organization of ABCA2, another member of the human ABC A transporter subfamily. The ABCA2 coding region is 7...
  2. Ile K, Davis W, Boyd J, Soulika A, Tew K. Identification of a novel first exon of the human ABCA2 transporter gene encoding a unique N-terminus. Biochim Biophys Acta. 2004;1678:22-32 pubmed
    The human ABCA2 transporter is a member of a large family of ATP-binding proteins that transport a variety of molecules across biological membranes...
  3. Mack J, Beljanski V, Soulika A, Townsend D, Brown C, Davis W, et al. "Skittish" Abca2 knockout mice display tremor, hyperactivity, and abnormal myelin ultrastructure in the central nervous system. Mol Cell Biol. 2007;27:44-53 pubmed
    The ATP-binding cassette transporter 2 (ABCA2) is an endolysosomal protein most highly expressed in the central and peripheral nervous system tissues and macrophages...
  4. Hu W, Lin X, Zhang H, Zhao N. ATP Binding Cassette Subfamily A Member 2 (ABCA2) Expression and Methylation are Associated with Alzheimer's Disease. Med Sci Monit. 2017;23:5851-5861 pubmed
    BACKGROUND ABCA2 has been genetically linked to Alzheimer's disease (AD) risk, but its mRNA expression and epigenetics in AD have not been investigated...
  5. Adams M, Dubnick M, Kerlavage A, Moreno R, Kelley J, Utterback T, et al. Sequence identification of 2,375 human brain genes. Nature. 1992;355:632-4 pubmed
    ..These data represent an approximate doubling of the number of human genes identified by DNA sequencing and may represent as many as 5% of the genes in the human genome. ..
  6. Soichi O, Masanori N, Hideo T, Kazunori A, Nobuya I, Jun ichi K. Clinical significance of ABCA2' a possible molecular marker for oligodendrogliomas. Neurosurgery. 2007;60:707-14; discussion 714 pubmed
    b>ABCA2 is a member of the adenosine triphosphate-binding cassette transporter superfamily and is proposed to exert critical functions in the transmembrane transport of endogenous lipids such as myelin...
  7. Davis W. The ATP-binding cassette transporter-2 (ABCA2) increases endogenous amyloid precursor protein expression and Aβ fragment generation. Curr Alzheimer Res. 2010;7:566-77 pubmed
    The ATP binding cassette transporter-2 (ABCA2) has been genetically linked to Alzheimer's disease but the molecular mechanisms are unknown...
  8. Mack J, Helke K, Normand G, Green C, Townsend D, Tew K. ABCA2 transporter deficiency reduces incidence of TRAMP prostate tumor metastasis and cellular chemotactic migration. Cancer Lett. 2011;300:154-61 pubmed publisher
    In order to study the effects of ATP-binding cassette transporter 2 (ABCA2) deficiency on the progression of prostate cancer, congenic Abca2 knockout (KO) mice were crossed to the transgenic adenocarcinoma of the mouse prostate (TRAMP) ..
  9. Shawahna R, Uchida Y, Declèves X, Ohtsuki S, Yousif S, Dauchy S, et al. Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels. Mol Pharm. 2011;8:1332-41 pubmed publisher
    ..SLC2A1/GLUT1, SLC1A3/EAAT1, and SLC1A2/EAAT2 were the main SLC proteins whereas ABCG2/BCRP, ABCB1/MDR1, ABCA2 and ABCA8 were the main ABC quantified in isolated brain microvessels; ABCG2/BCRP was 1...
  10. Latif H, Sahin M, Tarasova J, Tarasova Y, Portnoy V, Nogales J, et al. Adaptive Evolution of Thermotoga maritima Reveals Plasticity of the ABC Transporter Network. Appl Environ Microbiol. 2015;81:5477-85 pubmed publisher
    ..Analysis of the ABC2 uptake porter families for carbohydrate and peptide transport revealed that the solute binding protein, often among ..
  11. Rahgozar S, Moafi A, Abedi M, Entezar E Ghaem M, Moshtaghian J, Ghaedi K, et al. mRNA expression profile of multidrug-resistant genes in acute lymphoblastic leukemia of children, a prognostic value for ABCA3 and ABCA2. Cancer Biol Ther. 2014;15:35-41 pubmed publisher
    ..The present study aims to investigate the mRNA expression profile of several genes of this family, including ABCA2, ABCA3, ABCB1/MDR1, MRP1/ABCC1, MRP3/ABCC3, ABCG2/BCRP, and the intracellular transporter MVP/LRP, in childhood ..
  12. Minster R, DeKosky S, Kamboh M. No association of DAPK1 and ABCA2 SNPs on chromosome 9 with Alzheimer's disease. Neurobiol Aging. 2009;30:1890-1 pubmed publisher
    Recently genetic variation in the DAPK1 and ABCA2 genes has been reported to be associated with late- and early-onset Alzheimer's disease (AD), respectively...
  13. Tay W, Mahon R, Heckel D, Walsh T, Downes S, James W, et al. Insect Resistance to Bacillus thuringiensis Toxin Cry2Ab Is Conferred by Mutations in an ABC Transporter Subfamily A Protein. PLoS Genet. 2015;11:e1005534 pubmed publisher
    ..punctigera homolog from the resistant line. All mutations truncate the ABCA2 protein. Isolation of further Cry2Ab resistance alleles in the same gene from field H...
  14. Davis W, Chen Z, Ile K, Tew K. Reciprocal regulation of expression of the human adenosine 5'-triphosphate binding cassette, sub-family A, transporter 2 (ABCA2) promoter by the early growth response-1 (EGR-1) and Sp-family transcription factors. Nucleic Acids Res. 2003;31:1097-107 pubmed
    The human ABCA2 transporter gene encodes a member of a large family of ATP-binding proteins that transport a variety of macromolecules across biological membranes...
  15. Tanaka Y, Yamada K, Zhou C, Ban N, Shioda S, Inagaki N. Temporal and spatial profiles of ABCA2-expressing oligodendrocytes in the developing rat brain. J Comp Neurol. 2003;455:353-67 pubmed
    b>ABCA2 protein belongs to the ABCA subclass of ATP-binding cassette (ABC) transporters proposed to exert critical functions in transmembrane transport of endogenous lipids...
  16. Zhou C, Inagaki N, Pleasure S, Zhao L, Kikuyama S, Shioda S. ATP-binding cassette transporter ABCA2 (ABC2) expression in the developing spinal cord and PNS during myelination. J Comp Neurol. 2002;451:334-45 pubmed
    We examined developmental characteristics of the ATP-binding cassette transporter ABCA2 (or ABC2) -expressing cells in rat spinal cord and peripheral nerves...
  17. Davis W. The ATP-binding cassette transporter-2 (ABCA2) regulates cholesterol homeostasis and low-density lipoprotein receptor metabolism in N2a neuroblastoma cells. Biochim Biophys Acta. 2011;1811:1152-64 pubmed publisher
    The ATP-binding cassette transporter-2 (ABCA2) has been identified as a possible regulator of lipid metabolism...
  18. Borel F, Han R, Visser A, Petry H, van Deventer S, Jansen P, et al. Adenosine triphosphate-binding cassette transporter genes up-regulation in untreated hepatocellular carcinoma is mediated by cellular microRNAs. Hepatology. 2012;55:821-32 pubmed publisher
    ..Twelve ABC transporters showed up-regulation in HCC compared with adjacent healthy liver. These include ABCA2, ABCB1, ABCB6, ABCC1, ABCC2, ABCC3, ABCC4, ABCC5, ABCC10, ABCC11, ABCC12, and ABCE1...
  19. Michaki V, Guix F, Vennekens K, Munck S, Dingwall C, Davis J, et al. Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-β production by altering Nicastrin maturation and intracellular localization. J Biol Chem. 2012;287:1100-11 pubmed publisher
    ..The ATP-binding cassette transporter-2 (Abca2), which plays a role in intracellular sterol trafficking, has been genetically linked to AD...
  20. Mack J, Brown C, Garrett T, Uys J, Townsend D, Tew K. Ablation of the ATP-binding cassette transporter, Abca2 modifies response to estrogen-based therapies. Biomed Pharmacother. 2012;66:403-8 pubmed publisher
    The ATP-binding cassette transporter 2 (ABCA2) is an endolysosomal protein expressed in oligodendrocytes and Schwann cells, prostate, ovary and macrophages...
  21. Davis W. The ATP-binding cassette transporter-2 (ABCA2) regulates esterification of plasma membrane cholesterol by modulation of sphingolipid metabolism. Biochim Biophys Acta. 2014;1841:168-79 pubmed publisher
    ..The ABC "A" subfamily is comprised of 13 members and transport sterols, phospholipids and bile acids. ABCA2 is the most abundant ABC transporter in human and rodent brain with highest expression in oligodendrocytes, ..
  22. Ni W, Ji J, Dai Z, Papp A, Johnson A, Ahn S, et al. Flavopiridol pharmacogenetics: clinical and functional evidence for the role of SLCO1B1/OATP1B1 in flavopiridol disposition. PLoS ONE. 2010;5:e13792 pubmed publisher
    ..This study aimed to evaluate pharmacogenetic factors associated with inter-individual variability in pharmacokinetics and outcomes associated with flavopiridol therapy...
  23. Davis W. The ATP-Binding Cassette Transporter-2 (ABCA2) Overexpression Modulates Sphingosine Levels and Transcription of the Amyloid Precursor Protein (APP) Gene. Curr Alzheimer Res. 2015;12:847-59 pubmed
    The ATP-binding cassette transporter-2 (ABCA2) is a member of a family of multipass transmembrane proteins that use the energy of ATP hydrolysis to transport substrates across membrane bilayers...
  24. Mendoza Cózatl D, Zhai Z, Jobe T, Akmakjian G, Song W, Limbo O, et al. Tonoplast-localized Abc2 transporter mediates phytochelatin accumulation in vacuoles and confers cadmium tolerance. J Biol Chem. 2010;285:40416-26 pubmed publisher
    ..pombe microsomal vesicles. Systematic analysis of the entire S. pombe ABC transporter family identified Abc2 as a full-size ABC transporter (ABCC-type) that mediates phytochelatin transport into vacuoles. The S...
  25. Davis W, Tew K. ATP-binding cassette transporter-2 (ABCA2) as a therapeutic target. Biochem Pharmacol. 2017;: pubmed publisher
    The ATP binding cassette transporter ABCA2 is primarily an endolysosomal membrane protein that demonstrates pleiotropic functionalities, coalescing around the maintenance of homeostasis of sterols, sphingolipids and cholesterol...
  26. Kim W, Rahmanto A, Kamili A, Rye K, Guillemin G, Gelissen I, et al. Role of ABCG1 and ABCA1 in regulation of neuronal cholesterol efflux to apolipoprotein E discs and suppression of amyloid-beta peptide generation. J Biol Chem. 2007;282:2851-61 pubmed
    ..ATP-binding cassette transporters ABCA1, ABCA2, and ABCG1 were detected in neurons and neuroblastoma cell lines and expression of these cDNAs revealed that ABCA1 ..
  27. Burnie J, Carter T, Rigg G, Hodgetts S, Donohoe M, Matthews R. Identification of ABC transporters in vancomycin-resistant Enterococcus faecium as potential targets for antibody therapy. FEMS Immunol Med Microbiol. 2002;33:179-89 pubmed
    ..A partial sequence (putative VRE ABC2) was also obtained, in the same recombinant clone, of a second ABC transporter with 72% homologue with ybaE from B...
  28. Allikmets R, Gerrard B, Glavac D, Ravnik Glavac M, Jenkins N, Gilbert D, et al. Characterization and mapping of three new mammalian ATP-binding transporter genes from an EST database. Mamm Genome. 1995;6:114-7 pubmed
    ..additional clones, EST 600 and EST 1596, were found to represent different ATP-binding domains of the same gene, ABC2. This gene was localized to 9q34 in humans by FISH and to the proximal region of Chr 2 in mice by linkage analysis...
  29. Luciani M, Denizot F, Savary S, Mattei M, Chimini G. Cloning of two novel ABC transporters mapping on human chromosome 9. Genomics. 1994;21:150-9 pubmed
    ..Two novel mammalian members of the family, ABC1 and ABC2, have been identified by a PCR-based approach...
  30. Zhang F, Hogue D, Liu L, Fisher C, Hui D, Childs S, et al. M-ABC2, a new human mitochondrial ATP-binding cassette membrane protein. FEBS Lett. 2000;478:89-94 pubmed
    ..The new protein, which is most similar to the mitochondrial (M)-ABC1 protein, was also localized to mitochondria and therefore designated 'M-ABC2'. The N-terminus of M-ABC2 was shown to contain a mitochondrial-targeting signal sequence.
  31. Zhao L, Zhou C, Tanaka A, Nakata M, Hirabayashi T, Amachi T, et al. Cloning, characterization and tissue distribution of the rat ATP-binding cassette (ABC) transporter ABC2/ABCA2. Biochem J. 2000;350 Pt 3:865-72 pubmed
    ..Here we report the cloning, molecular characterization and tissue distribution of ABC2/ABCA2, which belongs to the ABC1 subfamily. Rat ABC2 is a protein of 2434 amino acids that has 44.5%, 40.0% and 40...
  32. Vulevic B, Chen Z, Boyd J, Davis W, Walsh E, Belinsky M, et al. Cloning and characterization of human adenosine 5'-triphosphate-binding cassette, sub-family A, transporter 2 (ABCA2). Cancer Res. 2001;61:3339-47 pubmed
    We have isolated the full-length cDNA for human ATP-binding cassette, sub-family A, member 2 transporter (ABCA2). The ORF of this cDNA encodes a protein consisting of 2436 amino acids with apparent molecular weight of M(r) 270,000...
  33. Klucken J, Büchler C, Orso E, Kaminski W, Porsch Ozcurumez M, Liebisch G, et al. ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport. Proc Natl Acad Sci U S A. 2000;97:817-22 pubmed
    ..Our results demonstrating a regulator function for ABCG1 in cholesterol and phospholipid transport define a biologic activity for ABC transporters in macrophages...
  34. Saito T, Yamada K, Wang Y, Tanaka Y, Ohtomo K, Ishikawa K, et al. Expression of ABCA2 protein in both non-myelin-forming and myelin-forming Schwann cells in the rodent peripheral nerve. Neurosci Lett. 2007;414:35-40 pubmed
    We previously reported that ABCA2, of the A subclass of the ATP-binding cassette (ABC) transporter superfamily, is expressed in mature oligodendrocytes and Schwann cells, the cells responsible for myelination in the brain and the ..
  35. Ohtsuki S, Kamoi M, Watanabe Y, Suzuki H, Hori S, Terasaki T. Correlation of induction of ATP binding cassette transporter A5 (ABCA5) and ABCB1 mRNAs with differentiation state of human colon tumor. Biol Pharm Bull. 2007;30:1144-6 pubmed
    ..ABCB1 mRNA was also detected in GI-112, while ABCC1 and ABCA2 mRNAs were not...
  36. Kim W, Weickert C, Garner B. Role of ATP-binding cassette transporters in brain lipid transport and neurological disease. J Neurochem. 2008;104:1145-66 pubmed
    ..the 48 transcriptionally active ABC transporters in the human genome, we have focused on 13 transporters (ABCA1, ABCA2, ABCA3, ABCA4, ABCA7 and ABCA8; ABCB1 and ABCB4; ABCD1 and ABCD2; ABCG1, ABCG2, and ABCG4) for which there is ..
  37. Elsnerova K, Bartakova A, Tihlarik J, Bouda J, Rob L, Skapa P, et al. Gene Expression Profiling Reveals Novel Candidate Markers of Ovarian Carcinoma Intraperitoneal Metastasis. J Cancer. 2017;8:3598-3606 pubmed publisher
    ..High expressions of ABCA2/8/9/10, ABCB1, ABCC9, ABCG2, ATP7A, SLC16A14, and ..
  38. Homma K, Kikuno R, Nagase T, Ohara O, Nishikawa K. Alternative splice variants encoding unstable protein domains exist in the human brain. J Mol Biol. 2004;343:1207-20 pubmed
    ..We propose that most unstable proteins encoded by alternative splice variants lack normal functions and are an evolutionary dead-end. ..
  39. Barrera M, Rojas L, Weiss A, Fernández O, MCMAHON PRATT D, Saravia N, et al. Profiling gene expression of antimony response genes in Leishmania (Viannia) panamensis and infected macrophages and its relationship with drug susceptibility. Acta Trop. 2017;176:355-363 pubmed publisher
    ..V.) panamensis line. However, this was not found in clinical strains, in which the expression of abca2 was significantly higher in resistant strains as both, promastigotes and intracellular amastigotes...
  40. Chen Z, Vulevic B, Ile K, Soulika A, Davis W, Reiner P, et al. Association of ABCA2 expression with determinants of Alzheimer's disease. FASEB J. 2004;18:1129-31 pubmed
    ..were identified in a HEK293 cell line engineered to overexpress the human ATP binding cassette transporter ABCA2. These included fatty acid binding protein, phospholipid binding protein, phospholipid synthesis protein, ..
  41. Li J, Ma Y, Yuan W, Xiao Y, Liu C, Wang J, et al. FOXA transcriptional factor modulates insect susceptibility to Bacillus thuringiensis Cry1Ac toxin by regulating the expression of toxin-receptor ABCC2 and ABCC3 genes. Insect Biochem Mol Biol. 2017;88:1-11 pubmed publisher
    ..Recently, it was shown that ATP-binding cassette transporter proteins (ABC) such as ABCC2, ABCC3, ABCG1 and ABCA2 are implicated in the insecticidal action of Cry toxins as putative receptors...
  42. Alla V, Kowtharapu B, Engelmann D, Emmrich S, Schmitz U, Steder M, et al. E2F1 confers anticancer drug resistance by targeting ABC transporter family members and Bcl-2 via the p73/DNp73-miR-205 circuitry. Cell Cycle. 2012;11:3067-78 pubmed publisher
    ..removing the inhibitory effect of miR-205 on the expression of Bcl-2 and the ATP-binding cassette transporters A2 (ABCA2) and A5 (ABCA5) related to multi-drug resistance and malignant progression...
  43. Connors T, Van Raay T, Petry L, Klinger K, Landes G, Burn T. The cloning of a human ABC gene (ABC3) mapping to chromosome 16p13.3. Genomics. 1997;39:231-4 pubmed
    ..We describe a human ABC protein with regions of strong homology to the recently described murine ABC1 and ABC2 transporters...
  44. Beljanski V, Soulika A, Tucker J, Townsend D, Davis W, Tew K. Characterization of the ATPase activity of human ATP-binding cassette transporter-2 (ABCA2). In Vivo. 2005;19:657-60 pubmed
    b>ABCA2 is a member of the ATP binding cassette transporter family with functional roles in cholesterol homeostasis and drug resistance.
  45. Kaminski W, Wenzel J, Piehler A, Langmann T, Schmitz G. ABCA6, a novel a subclass ABC transporter. Biochem Biophys Res Commun. 2001;285:1295-301 pubmed
    ..subfamily A the novel transporter shows highest protein sequence homology with ABCA8 (60%), followed by ABCA2 (32%) and ABCA1 (32%), respectively...
  46. Kim W, Guillemin G, Glaros E, Lim C, Garner B. Quantitation of ATP-binding cassette subfamily-A transporter gene expression in primary human brain cells. Neuroreport. 2006;17:891-6 pubmed
    Five ATP-binding cassette (ABC) subfamily-A transporters (ABCA1, ABCA2, ABCA3, ABCA7 and ABCA8) are expressed in the brain...
  47. Illing M, Molday L, Molday R. The 220-kDa rim protein of retinal rod outer segments is a member of the ABC transporter superfamily. J Biol Chem. 1997;272:10303-10 pubmed
    ..search showed that the rod outer segment 220-kDa protein is 40-50% identical in amino acid sequence to the ABC1 and ABC2 proteins cloned from a mouse macrophage cell line...
  48. Iwaki T, Giga Hama Y, Takegawa K. A survey of all 11 ABC transporters in fission yeast: two novel ABC transporters are required for red pigment accumulation in a Schizosaccharomyces pombe adenine biosynthetic mutant. Microbiology. 2006;152:2309-21 pubmed
    ..The doubly disrupted mutant abc2 Delta abc4 Delta exhibited drug sensitivity, and a decreased accumulation of monochlorobimane, suggesting that both ..
  49. Wollmer M, Kapaki E, Hersberger M, Muntwyler J, Brunner F, Tsolaki M, et al. Ethnicity-dependent genetic association of ABCA2 with sporadic Alzheimer's disease. Am J Med Genet B Neuropsychiatr Genet. 2006;141B:534-6 pubmed
    A recent study demonstrated a significant genetic association between the ATP-binding cassette transporter A2 (ABCA2) and the risk for Alzheimer's disease (AD) in a large Caucasian sample...
  50. Dharmapuri G, Doneti R, Philip G, Kalle A. Celecoxib sensitizes imatinib-resistant K562 cells to imatinib by inhibiting MRP1-5, ABCA2 and ABCG2 transporters via Wnt and Ras signaling pathways. Leuk Res. 2015;39:696-701 pubmed publisher
    ..Here, we tried to study the role of COX-2 in the regulation of other ABC transporters such as MRP1, MRP2, MRP3, ABCA2 and ABCG2 that have been already implicated in imatinib resistance development...
  51. Ricardo E, Miranda I, Faria Ramos I, Silva R, Rodrigues A, Pina Vaz C. In vivo and in vitro acquisition of resistance to voriconazole by Candida krusei. Antimicrob Agents Chemother. 2014;58:4604-11 pubmed publisher
    ..gene expression increased over time in both the in vivo- and in vitro-induced resistant strains, in contrast to the ABC2 and ERG11 genes, whose expression was invariably lower and constant...
  52. Efferth T, Gillet J, Sauerbrey A, Zintl F, Bertholet V, de Longueville F, et al. Expression profiling of ATP-binding cassette transporters in childhood T-cell acute lymphoblastic leukemia. Mol Cancer Ther. 2006;5:1986-94 pubmed
    ..for the simultaneous quantification of 38 ABC transporter genes, we observed a consistent overexpression of ABCA2/ABCA3 in clinical samples of ALL. Therefore, we analyzed the association of these two genes with drug resistance...
  53. Calpe Berdiel L, Zhao Y, de Graauw M, Ye D, Van Santbrink P, Mommaas A, et al. Macrophage ABCA2 deletion modulates intracellular cholesterol deposition, affects macrophage apoptosis, and decreases early atherosclerosis in LDL receptor knockout mice. Atherosclerosis. 2012;223:332-41 pubmed publisher
    The ABCA2 transporter shares high structural homology to ABCA1, which is crucial for the removal of excess cholesterol from macrophages and, by extension, in atherosclerosis...
  54. Broccardo C, Nieoullon V, Amin R, Masmejean F, Carta S, Tassi S, et al. ABCA2 is a marker of neural progenitors and neuronal subsets in the adult rodent brain. J Neurochem. 2006;97:345-55 pubmed
    The notion that the ATP-binding cassette transporter-A2 (ABCA2) may be involved in brain sterol homeostasis and is associated with early onset Alzheimer's disease led us to explore its neural expression...
  55. Schmitz G, Kaminski W. ABCA2: a candidate regulator of neural transmembrane lipid transport. Cell Mol Life Sci. 2002;59:1285-95 pubmed
    ..These pioneering observations have directed considerable attention to the A subfamily of ABC proteins. ABCA2 is the codefining member of the ABC A-transporter subclass...
  56. Davis W, Boyd J, Ile K, Tew K. Human ATP-binding cassette transporter-2 (ABCA2) positively regulates low-density lipoprotein receptor expression and negatively regulates cholesterol esterification in Chinese hamster ovary cells. Biochim Biophys Acta. 2004;1683:89-100 pubmed
    We present evidence that the ATP binding-cassette transporter-2 (ABCA2) is a sterol-responsive gene that has a role in the trafficking of low-density lipoprotein-derived free cholesterol (LDL-FC)...
  57. Mace S, Cousin E, Ricard S, Genin E, Spanakis E, Lafargue Soubigou C, et al. ABCA2 is a strong genetic risk factor for early-onset Alzheimer's disease. Neurobiol Dis. 2005;18:119-25 pubmed
    ..Based on these data, we postulated that genetic variation in the related and brain-specific ABCA2 gene leads to increase risk of AD...
  58. Wang Y, Yamada K, Tanaka Y, Ishikawa K, Inagaki N. Expression of ABCA2 protein in human vestibular schwannoma and peripheral nerve. J Neurol Sci. 2005;232:59-63 pubmed
    b>ABCA2, which belongs to the A subclass of the ATP-binding cassette (ABC) transporter superfamily, is predominantly expressed in the cytoplasm of oligodendrocytes and Schwann cells, the myelin-forming cells in brain and peripheral nerve, ..
  59. Sakai H, Tanaka Y, Tanaka M, Ban N, Yamada K, Matsumura Y, et al. ABCA2 deficiency results in abnormal sphingolipid metabolism in mouse brain. J Biol Chem. 2007;282:19692-9 pubmed
    b>ABCA2, a member of the ATP-binding cassette (ABC) transporter family, is localized mainly to late endosome/lysosomes of oligodendrocytes in brain, but the physiological role and function of ABCA2 are unknown...