ABC7

Summary

Gene Symbol: ABC7
Description: ATP binding cassette subfamily B member 7
Alias: ABC7, ASAT, Atm1p, EST140535, ATP-binding cassette sub-family B member 7, mitochondrial, ABC transporter 7 protein, ATP-binding cassette transporter 7, ATP-binding cassette, sub-family B (MDR/TAP), member 7
Species: human
Products:     ABC7

Top Publications

  1. Kispal G, Csere P, Prohl C, Lill R. The mitochondrial proteins Atm1p and Nfs1p are essential for biogenesis of cytosolic Fe/S proteins. EMBO J. 1999;18:3981-9 pubmed
    ..The ATP-binding cassette (ABC) transporter Atm1p of the mitochondrial inner membrane performs an essential function only in the generation of cytosolic Fe/S ..
  2. Allikmets R, Raskind W, Hutchinson A, Schueck N, Dean M, Koeller D. Mutation of a putative mitochondrial iron transporter gene (ABC7) in X-linked sideroblastic anemia and ataxia (XLSA/A). Hum Mol Genet. 1999;8:743-9 pubmed
    ..This gene, ABC7, is an ortholog of the yeast ATM1 gene whose product localizes to the mitochondrial inner membrane and is involved ..
  3. Bekri S, Kispal G, Lange H, Fitzsimons E, Tolmie J, Lill R, et al. Human ABC7 transporter: gene structure and mutation causing X-linked sideroblastic anemia with ataxia with disruption of cytosolic iron-sulfur protein maturation. Blood. 2000;96:3256-64 pubmed
    ..ABC7 belongs to the adenosine triphosphate-binding cassette transporter superfamily, and its yeast orthologue, Atm1p, plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins...
  4. Shimada Y, Okuno S, Kawai A, Shinomiya H, Saito A, Suzuki M, et al. Cloning and chromosomal mapping of a novel ABC transporter gene (hABC7), a candidate for X-linked sideroblastic anemia with spinocerebellar ataxia. J Hum Genet. 1998;43:115-22 pubmed
    ..human ATP-binding cassette (ABC) transporter cDNA, determined its nucleotide sequence, and designated it human ABC7 (hABC7)...
  5. Lerebours A, To V, Bourdineaud J. Danio rerio ABC transporter genes abcb3 and abcb7 play a protecting role against metal contamination. J Appl Toxicol. 2016;36:1551-1557 pubmed publisher
    ..5 and 2-times lower than in the control. This work provides new data on the function of zebrafish ABCB3 and ABCB7 transporters and highlights their significance in metal detoxification. Copyright © 2016 John Wiley & Sons, Ltd. ..
  6. Iwaki T, Fujita Y, Tanaka N, Giga Hama Y, Takegawa K. Mitochondrial ABC transporter Atm1p is required for protection against oxidative stress and vacuolar functions in Schizosaccharomyces pombe. Biosci Biotechnol Biochem. 2005;69:2109-16 pubmed
    ..Growth of the atm1 mutant was inhibited in the presence of oxidizing agents, and S. cerevisiae Atm1p was found to complement this growth defect...
  7. Qi W, Li J, Cowan J. A structural model for glutathione-complexed iron-sulfur cluster as a substrate for ABCB7-type transporters. Chem Commun (Camb). 2014;50:3795-8 pubmed publisher
    ..A possible substrate-binding site is identified on a new structural model for the active transporter. ..
  8. Saito S, Iida A, Sekine A, Miura Y, Ogawa C, Kawauchi S, et al. Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population. J Hum Genet. 2002;47:38-50 pubmed
    ..These variants may contribute to investigations of possible correlations between genotypes and disease-susceptibility phenotypes or responsiveness to drug therapy...
  9. Pondarre C, Campagna D, Antiochos B, Sikorski L, Mulhern H, Fleming M. Abcb7, the gene responsible for X-linked sideroblastic anemia with ataxia, is essential for hematopoiesis. Blood. 2007;109:3567-9 pubmed
    ..Here, we show that Abcb7 is essential for hematopoiesis and formally demonstrate that XLSA/A is due to partial loss of function mutations in Abcb7 that directly or indirectly inhibit heme biosynthesis...
  10. Martínez García M, Campos Salinas J, Cabello Donayre M, Pineda Molina E, Gálvez F, Orrego L, et al. LmABCB3, an atypical mitochondrial ABC transporter essential for Leishmania major virulence, acts in heme and cytosolic iron/sulfur clusters biogenesis. Parasit Vectors. 2016;9:7 pubmed publisher
    ..Leishmania infects human macrophages producing the neglected tropical disease known as leishmaniasis. Like most trypanosomatid parasites, Leishmania is auxotrophous for heme and must acquire porphyrins from the host...

Detail Information

Publications58

  1. Kispal G, Csere P, Prohl C, Lill R. The mitochondrial proteins Atm1p and Nfs1p are essential for biogenesis of cytosolic Fe/S proteins. EMBO J. 1999;18:3981-9 pubmed
    ..The ATP-binding cassette (ABC) transporter Atm1p of the mitochondrial inner membrane performs an essential function only in the generation of cytosolic Fe/S ..
  2. Allikmets R, Raskind W, Hutchinson A, Schueck N, Dean M, Koeller D. Mutation of a putative mitochondrial iron transporter gene (ABC7) in X-linked sideroblastic anemia and ataxia (XLSA/A). Hum Mol Genet. 1999;8:743-9 pubmed
    ..This gene, ABC7, is an ortholog of the yeast ATM1 gene whose product localizes to the mitochondrial inner membrane and is involved ..
  3. Bekri S, Kispal G, Lange H, Fitzsimons E, Tolmie J, Lill R, et al. Human ABC7 transporter: gene structure and mutation causing X-linked sideroblastic anemia with ataxia with disruption of cytosolic iron-sulfur protein maturation. Blood. 2000;96:3256-64 pubmed
    ..ABC7 belongs to the adenosine triphosphate-binding cassette transporter superfamily, and its yeast orthologue, Atm1p, plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins...
  4. Shimada Y, Okuno S, Kawai A, Shinomiya H, Saito A, Suzuki M, et al. Cloning and chromosomal mapping of a novel ABC transporter gene (hABC7), a candidate for X-linked sideroblastic anemia with spinocerebellar ataxia. J Hum Genet. 1998;43:115-22 pubmed
    ..human ATP-binding cassette (ABC) transporter cDNA, determined its nucleotide sequence, and designated it human ABC7 (hABC7)...
  5. Lerebours A, To V, Bourdineaud J. Danio rerio ABC transporter genes abcb3 and abcb7 play a protecting role against metal contamination. J Appl Toxicol. 2016;36:1551-1557 pubmed publisher
    ..5 and 2-times lower than in the control. This work provides new data on the function of zebrafish ABCB3 and ABCB7 transporters and highlights their significance in metal detoxification. Copyright © 2016 John Wiley & Sons, Ltd. ..
  6. Iwaki T, Fujita Y, Tanaka N, Giga Hama Y, Takegawa K. Mitochondrial ABC transporter Atm1p is required for protection against oxidative stress and vacuolar functions in Schizosaccharomyces pombe. Biosci Biotechnol Biochem. 2005;69:2109-16 pubmed
    ..Growth of the atm1 mutant was inhibited in the presence of oxidizing agents, and S. cerevisiae Atm1p was found to complement this growth defect...
  7. Qi W, Li J, Cowan J. A structural model for glutathione-complexed iron-sulfur cluster as a substrate for ABCB7-type transporters. Chem Commun (Camb). 2014;50:3795-8 pubmed publisher
    ..A possible substrate-binding site is identified on a new structural model for the active transporter. ..
  8. Saito S, Iida A, Sekine A, Miura Y, Ogawa C, Kawauchi S, et al. Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population. J Hum Genet. 2002;47:38-50 pubmed
    ..These variants may contribute to investigations of possible correlations between genotypes and disease-susceptibility phenotypes or responsiveness to drug therapy...
  9. Pondarre C, Campagna D, Antiochos B, Sikorski L, Mulhern H, Fleming M. Abcb7, the gene responsible for X-linked sideroblastic anemia with ataxia, is essential for hematopoiesis. Blood. 2007;109:3567-9 pubmed
    ..Here, we show that Abcb7 is essential for hematopoiesis and formally demonstrate that XLSA/A is due to partial loss of function mutations in Abcb7 that directly or indirectly inhibit heme biosynthesis...
  10. Martínez García M, Campos Salinas J, Cabello Donayre M, Pineda Molina E, Gálvez F, Orrego L, et al. LmABCB3, an atypical mitochondrial ABC transporter essential for Leishmania major virulence, acts in heme and cytosolic iron/sulfur clusters biogenesis. Parasit Vectors. 2016;9:7 pubmed publisher
    ..Leishmania infects human macrophages producing the neglected tropical disease known as leishmaniasis. Like most trypanosomatid parasites, Leishmania is auxotrophous for heme and must acquire porphyrins from the host...
  11. Laloy J, Lozano O, Alpan L, Mejia J, Toussaint O, Masereel B, et al. Can TiC nanoparticles produce toxicity in oral administration to rats?. Toxicol Rep. 2014;1:172-187 pubmed publisher
    ..In the acute administration, alkaline phosphatases increased (5, 300 and 1000 mg kg-1), ASAT increased (1000 mg kg-1) and bile salts decreased (0.5 mg kg-1)...
  12. Sato K, Torimoto Y, Hosoki T, Ikuta K, Takahashi H, Yamamoto M, et al. Loss of ABCB7 gene: pathogenesis of mitochondrial iron accumulation in erythroblasts in refractory anemia with ringed sideroblast with isodicentric (X)(q13). Int J Hematol. 2011;93:311-8 pubmed publisher
    ..These findings suggest that loss of the ABCB7 gene may be a pathogenetic factor underlying mitochondrial iron accumulation in RARS patients with idicXq13...
  13. Bernard D, Cheng Y, Zhao Y, Balk J. An allelic mutant series of ATM3 reveals its key role in the biogenesis of cytosolic iron-sulfur proteins in Arabidopsis. Plant Physiol. 2009;151:590-602 pubmed publisher
    ..arginine-612 is replaced by a lysine residue, the negative effect of which could be mimicked in the yeast Atm1p ortholog...
  14. Bergmann A, Campagna D, McLoughlin E, Agarwal S, Fleming M, Bottomley S, et al. Systematic molecular genetic analysis of congenital sideroblastic anemia: evidence for genetic heterogeneity and identification of novel mutations. Pediatr Blood Cancer. 2010;54:273-8 pubmed publisher
    ..Despite these known diverse causes, in a substantial portion of CSA cases a presumed genetic defect remains unknown...
  15. Taketani S, Kakimoto K, Ueta H, Masaki R, Furukawa T. Involvement of ABC7 in the biosynthesis of heme in erythroid cells: interaction of ABC7 with ferrochelatase. Blood. 2003;101:3274-80 pubmed
    A mitochondrial half-type ATP-binding cassette (ABC) protein, ABC7, plays a role in iron homeostasis in mitochondria, and defects in human ABC7 were shown to be responsible for the inherited disease X-linked sideroblastic anemia/ataxia...
  16. Gonzalez Cabo P, Bolinches Amorós A, Cabello J, Ros S, Moreno S, Baylis H, et al. Disruption of the ATP-binding cassette B7 (ABTM-1/ABCB7) induces oxidative stress and premature cell death in Caenorhabditis elegans. J Biol Chem. 2011;286:21304-14 pubmed publisher
    ..Therefore, ablation of abtm-1 in C. elegans provides a model in which to investigate the mechanism underlying XLSA/A...
  17. Kiss K, Brozik A, Kucsma N, Toth A, Gera M, Berry L, et al. Shifting the paradigm: the putative mitochondrial protein ABCB6 resides in the lysosomes of cells and in the plasma membrane of erythrocytes. PLoS ONE. 2012;7:e37378 pubmed publisher
    ..Taken together, our results challenge the current paradigm linking the expression and function of ABCB6 to mitochondria...
  18. Ueta R, Fujiwara N, Iwai K, Yamaguchi Iwai Y. Iron-induced dissociation of the Aft1p transcriptional regulator from target gene promoters is an initial event in iron-dependent gene suppression. Mol Cell Biol. 2012;32:4998-5008 pubmed publisher
    ..The mitochondrial transporter Atm1p, which has been implicated in the export of iron-sulfur clusters and related molecules, is required not only for ..
  19. Li J, Cowan J. Glutathione-coordinated [2Fe-2S] cluster: a viable physiological substrate for mitochondrial ABCB7 transport. Chem Commun (Camb). 2015;51:2253-5 pubmed publisher
    ..cluster is demonstrated to be a viable and likely substrate for physiological iron-sulfur cluster transport by Atm1p, a mitochondrial ABC export protein...
  20. Lill R, Dutkiewicz R, Freibert S, Heidenreich T, Mascarenhas J, Netz D, et al. The role of mitochondria and the CIA machinery in the maturation of cytosolic and nuclear iron-sulfur proteins. Eur J Cell Biol. 2015;94:280-91 pubmed publisher
    ....
  21. Bailey C, Tully M, Pampaka M, Cooke J. Rasch analysis of the Antimicrobial Self-Assessment Toolkit for National Health Service (NHS) Trusts (ASAT v17). J Antimicrob Chemother. 2017;72:604-613 pubmed publisher
    The Antimicrobial Self-Assessment Toolkit for National Health Service (NHS) Trusts (ASAT) was developed to evaluate hospital-based antimicrobial stewardship programmes...
  22. Savary S, Allikmets R, Denizot F, Luciani M, Mattei M, Dean M, et al. Isolation and chromosomal mapping of a novel ATP-binding cassette transporter conserved in mouse and human. Genomics. 1997;41:275-8 pubmed
    ..identification and genomic mapping of a novel member of the family of the ATP-binding cassette (ABC) transporters, ABC7, conserved in mouse and in humans...
  23. Srinivasan V, Pierik A, Lill R. Crystal structures of nucleotide-free and glutathione-bound mitochondrial ABC transporter Atm1. Science. 2014;343:1137-40 pubmed publisher
    ..The resulting protein stabilization may be a common structural feature of all ABC exporters. ..
  24. Nikpour M, Scharenberg C, Liu A, Conte S, Karimi M, Mortera Blanco T, et al. The transporter ABCB7 is a mediator of the phenotype of acquired refractory anemia with ring sideroblasts. Leukemia. 2013;27:889-896 pubmed publisher
    ..Our findings support that ABCB7 is implicated in the phenotype of acquired RARS and suggest a relation between SF3B1 mutations and ABCB7 downregulation...
  25. Allikmets R, Gerrard B, Hutchinson A, Dean M. Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database. Hum Mol Genet. 1996;5:1649-55 pubmed
    ....
  26. Schaedler T, Faust B, Shintre C, Carpenter E, Srinivasan V, van Veen H, et al. Structures and functions of mitochondrial ABC transporters. Biochem Soc Trans. 2015;43:943-51 pubmed publisher
    ..Combined with in vitro and in vivo studies, progress is being made to find the physiological substrates of the different mitochondrial ABC transporters. ..
  27. Auger F, Martin F, Petrault O, Samaillie J, Hennebelle T, Trabelsi M, et al. Risperidone-induced metabolic dysfunction is attenuated by Curcuma longa extract administration in mice. Metab Brain Dis. 2018;33:63-77 pubmed publisher
    ..Curcumin decreased risperidone-induced increases in serum markers of hepatotoxicity (ALAT, ASAT), as well as of one major hepatic pro-inflammatory transcription factor (NFκB: p105 mRNA and p65 protein)...
  28. Ye H, Rouault T. Human iron-sulfur cluster assembly, cellular iron homeostasis, and disease. Biochemistry. 2010;49:4945-56 pubmed publisher
    ....
  29. Camaschella C. Hereditary sideroblastic anemias: pathophysiology, diagnosis, and treatment. Semin Hematol. 2009;46:371-7 pubmed publisher
    ....
  30. Petit M, Mine L, Pascreau T, Brouzes C, Majoux S, Borgel D, et al. Preanalytical influence of pneumatic tube delivery system on results of routine biochemistry and haematology analysis. Ann Biol Clin (Paris). 2017;: pubmed publisher
    ..following analysis: ionized calcium, sodium, potassium, lactate deshydrogenase (LDH), aspartate aminotransferase (ASAT), arterial blood gas, complete blood count and coagulation test as prothrombin time, activated partial ..
  31. Zutz A, Gompf S, Schagger H, Tampe R. Mitochondrial ABC proteins in health and disease. Biochim Biophys Acta. 2009;1787:681-90 pubmed publisher
    ....
  32. Miao R, Kim H, Koppolu U, Ellis E, Scott R, Lindahl P. Biophysical characterization of the iron in mitochondria from Atm1p-depleted Saccharomyces cerevisiae. Biochemistry. 2009;48:9556-68 pubmed publisher
    b>Atm1p is an ABC transporter localized in the mitochondrial inner membrane; it functions to export an unknown species into the cytosol and is involved in cellular iron metabolism...
  33. Csere P, Lill R, Kispal G. Identification of a human mitochondrial ABC transporter, the functional orthologue of yeast Atm1p. FEBS Lett. 1998;441:266-70 pubmed
    ..and displays high sequence similarity to the mouse ABC7 protein and to the mitochondrial ABC transporter Atm1p of Saccharomyces cerevisiae...
  34. Miao L, Huang C, Hou J, Qian M. Association study of ABCB1 and CYP3A5 gene polymorphisms with sirolimus trough concentration and dose requirements in Chinese renal transplant recipients. Biopharm Drug Dispos. 2008;29:1-5 pubmed
    ..In patients with SRL-based therapy, genotyping of the CYP3A5 genes may help to optimize the SRL management in renal transplant recipients. ..
  35. Krishnamurthy P, Du G, Fukuda Y, Sun D, Sampath J, Mercer K, et al. Identification of a mammalian mitochondrial porphyrin transporter. Nature. 2006;443:586-9 pubmed
    ..This process is blocked when the Abcb6 gene is silenced. Our results challenge previous assumptions about the intracellular movement of porphyrins and the factors controlling haem biosynthesis...
  36. Corral Debrinski M, Blugeon C, Jacq C. In yeast, the 3' untranslated region or the presequence of ATM1 is required for the exclusive localization of its mRNA to the vicinity of mitochondria. Mol Cell Biol. 2000;20:7881-92 pubmed
    ..Some mRNAs exclusively localize to mitochondrion-bound polysomes, such as the ones coding for Atm1p, Cox10p, Tim44p, Atp2p, and Cot1p...
  37. Athmouni K, Belhaj D, El Feki A, Ayadi H. Optimization, antioxidant properties and GC-MS analysis of Periploca angustifolia polysaccharides and chelation therapy on cadmium-induced toxicity in human HepG2 cells line and rat liver. Int J Biol Macromol. 2017;: pubmed publisher
    ..decreased the content of MDA and protein damage in liver tissue, and enhanced liver function parameters (ALAT, ASAT and bilirubin), as well as the activities of hepatic antioxidant status (SOD, CAT, GPx and GSH)...
  38. Kispal G, Csere P, Guiard B, Lill R. The ABC transporter Atm1p is required for mitochondrial iron homeostasis. FEBS Lett. 1997;418:346-50 pubmed
    The function of the ABC transporter Atm1p located in the mitochondrial inner membrane is not yet known. To study its cellular role, we analyzed a mutant in which ATM1 was disrupted...
  39. Fahrner R, Möller A, Press A, Kortgen A, Kiehntopf M, Rauchfuss F, et al. Short-term treatment with taurolidine is associated with liver injury. BMC Pharmacol Toxicol. 2017;18:61 pubmed publisher
    ..After 24 h a significant increase of serum GLDH and ASAT was observed in rats treated with high-dose taurolidine treatment...
  40. Inokura K, Fujiwara T, Saito K, Iino T, Hatta S, Okitsu Y, et al. Impact of TET2 deficiency on iron metabolism in erythroblasts. Exp Hematol. 2017;49:56-67.e5 pubmed publisher
    ..Furthermore, Tet2 knockdown in erythroblasts resulted in decreased heme concentration and accumulation of FTMT. Therefore, TET2 plays a role in the iron and heme metabolism in erythroblasts. ..
  41. Mitsuhashi N, Miki T, Senbongi H, Yokoi N, Yano H, Miyazaki M, et al. MTABC3, a novel mitochondrial ATP-binding cassette protein involved in iron homeostasis. J Biol Chem. 2000;275:17536-40 pubmed
    b>Atm1p, a mitochondrial half-type ATP-binding cassette (ABC) protein in Saccharomyces cerevisiae, transports a precursor of the iron-sulfur (Fe/S) cluster from mitochondria to the cytosol...
  42. Lill R, Kispal G. Mitochondrial ABC transporters. Res Microbiol. 2001;152:331-40 pubmed
    ..fall into two major classes that, in the yeast Saccharomyces cerevisiae, are represented by the half-transporter Atm1p and the two closely homologous proteins Mdl1p and Mdl2p...
  43. Maguire A, Hellier K, Hammans S, May A. X-linked cerebellar ataxia and sideroblastic anaemia associated with a missense mutation in the ABC7 gene predicting V411L. Br J Haematol. 2001;115:910-7 pubmed
    ..protoporphyrin led to a search using a combination of DNA and cDNA analysis for the presence of mutations in the ABC7 gene. ABC7 encodes a mitochondrial half-type ATP Binding Cassette transporter involved in iron homeostasis...
  44. Chloupkova M, LeBard L, Koeller D. MDL1 is a high copy suppressor of ATM1: evidence for a role in resistance to oxidative stress. J Mol Biol. 2003;331:155-65 pubmed
    ..b>Atm1p is an ATP-binding cassette (ABC) transporter localized to the mitochondrial inner membrane...
  45. Liesa M, Qiu W, Shirihai O. Mitochondrial ABC transporters function: the role of ABCB10 (ABC-me) as a novel player in cellular handling of reactive oxygen species. Biochim Biophys Acta. 2012;1823:1945-57 pubmed publisher
    ..We discuss ABCB10 as a potential therapeutic target for diseases in which increased mitochondrial ROS production and oxidative stress play a major role...
  46. D Hooghe M, Selleslag D, Mortier G, Van Coster R, Vermeersch P, Billiet J, et al. X-linked sideroblastic anemia and ataxia: a new family with identification of a fourth ABCB7 gene mutation. Eur J Paediatr Neurol. 2012;16:730-5 pubmed publisher
    ..Until now only three families have been reported, each with a distinct missense mutation in this gene. We describe a fourth family with XLSA-A and a novel mutation in the ABCB7 gene...
  47. Chloupkova M, Reaves S, LeBard L, Koeller D. The mitochondrial ABC transporter Atm1p functions as a homodimer. FEBS Lett. 2004;569:65-9 pubmed
    ..In this study, we have evaluated the role of conserved sequence elements in Atm1p in its function and dimerization in vivo...
  48. Protasova M, Grigorenko A, Tyazhelova T, Andreeva T, Reshetov D, Gusev F, et al. Whole-genome sequencing identifies a novel ABCB7 gene mutation for X-linked congenital cerebellar ataxia in a large family of Mongolian ancestry. Eur J Hum Genet. 2016;24:550-5 pubmed publisher
    ..Our finding links cerebellar pathology to the genetic defect in ABCB7 and ATP7A structural variant inherited as X-linked trait, and further reveals the genetic heterogeneity of X-linked cerebellar disorders. ..
  49. Pondarre C, Antiochos B, Campagna D, Clarke S, Greer E, Deck K, et al. The mitochondrial ATP-binding cassette transporter Abcb7 is essential in mice and participates in cytosolic iron-sulfur cluster biogenesis. Hum Mol Genet. 2006;15:953-64 pubmed
    ..Abcb7, which is mutated in X-linked sideroblastic anemia with ataxia in humans, is a functional ortholog of yeast Atm1p and is predicted to export a mitochondrially derived metabolite required for cytosolic Fe-S cluster assembly...
  50. Kuhnke G, Neumann K, Muhlenhoff U, Lill R. Stimulation of the ATPase activity of the yeast mitochondrial ABC transporter Atm1p by thiol compounds. Mol Membr Biol. 2006;23:173-84 pubmed
    The ATP binding cassette (ABC) transporter Atm1p of the mitochondrial inner membrane performs crucial roles in both the biogenesis of cytosolic/nuclear iron-sulfur proteins and cellular iron homeostasis...
  51. Dolatshad H, Pellagatti A, Liberante F, Llorian M, Repapi E, Steeples V, et al. Cryptic splicing events in the iron transporter ABCB7 and other key target genes in SF3B1-mutant myelodysplastic syndromes. Leukemia. 2016;30:2322-2331 pubmed publisher
    ....
  52. Chen C, Cowan J. Characterization of Saccharomyces cerevisiae Atm1p: functional studies of an ABC7 type transporter. Biochim Biophys Acta. 2006;1760:1857-65 pubmed
    Saccharomyces cerevisiae Atm1p has been cloned, over-expressed and purified from a yeast expression system. The sequence includes both the soluble ATPase and transmembrane-spanning domains...
  53. El Gendy M, Abdel Wahhab K, Mannaa F, Farghaly A, El Bondkly A. Carcinogenic Activities and Sperm Abnormalities of Methicillin Resistance Staphylococcus aureus and Inhibition of Their Virulence Potentials by Ayamycin. Appl Biochem Biotechnol. 2017;183:833-852 pubmed publisher
    ..01) increases in the activities of the serum alanine aminotransferase (ALAT) and aspartate aminotransferase (ASAT) enzymes...
  54. Bedekovics T, Li H, Gajdos G, Isaya G. Leucine biosynthesis regulates cytoplasmic iron-sulfur enzyme biogenesis in an Atm1p-independent manner. J Biol Chem. 2011;286:40878-88 pubmed publisher
    ..precursors exported from the mitochondria via an ATP binding cassette (ABC) transporter conserved from yeast (Atm1p) to humans (ABCB7)...
  55. Boultwood J, Pellagatti A, Nikpour M, Pushkaran B, Fidler C, Cattan H, et al. The role of the iron transporter ABCB7 in refractory anemia with ring sideroblasts. PLoS ONE. 2008;3:e1970 pubmed publisher
    ..These data provide an important link between inherited and acquired forms of sideroblastic anemia and indicate that ABCB7 is a strong candidate gene for RARS...
  56. Mikolay A, Nies D. The ABC-transporter AtmA is involved in nickel and cobalt resistance of Cupriavidus metallidurans strain CH34. Antonie Van Leeuwenhoek. 2009;96:183-91 pubmed publisher
    Cupriavidus metallidurans CH34 genome contains an ortholog of Atm1p named AtmA (Rmet_0391, YP_582546)...
  57. Leighton J, Schatz G. An ABC transporter in the mitochondrial inner membrane is required for normal growth of yeast. EMBO J. 1995;14:188-95 pubmed
    ..This gene, termed ATM1, encodes a putative 'half-transporter' of 694 amino acids. Atm1p is synthesized with an N-terminal mitochondrial matrix-targeting signal and is located in the mitochondrial inner ..