AANAT

Summary

Gene Symbol: AANAT
Description: aralkylamine N-acetyltransferase
Alias: DSPS, SNAT, serotonin N-acetyltransferase, arylalkylamine N-acetyltransferase, serotonin acetylase
Species: human
Products:     AANAT

Top Publications

  1. Coon S, Mazuruk K, Bernard M, Roseboom P, Klein D, Rodriguez I. The human serotonin N-acetyltransferase (EC 2.3.1.87) gene (AANAT): structure, chromosomal localization, and tissue expression. Genomics. 1996;34:76-84 pubmed
    Serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AA-NAT, HGMW-approved symbol AANAT; EC 2.3.1...
  2. Wang C, Jones R, Debiec Rychter M, Soos G, Haas G. Correlation of the genotypes for N-acetyltransferases 1 and 2 with double bladder and prostate cancers in a case-comparison study. Anticancer Res. 2002;22:3529-35 pubmed
    ..13 of 34 controls (odds ratio 3.88; p = 0.040). Rapid NAT2 genotype correlated significantly with the development of double prostate-bladder cancer. ..
  3. Soria V, Martínez Amorós E, Escaramis G, Valero J, Crespo J, Gutierrez Zotes A, et al. Resequencing and association analysis of arylalkylamine N-acetyltransferase (AANAT) gene and its contribution to major depression susceptibility. J Pineal Res. 2010;49:35-44 pubmed publisher
    ..Arylalkylamine N-acetyltransferase (AANAT) is a key enzyme of the melatonin pathway involved in circadian oscillations of melatonin levels...
  4. Wu F, Lee Y, Chen D, Kuo H. Association of DNA-protein crosslinks and breast cancer. Mutat Res. 2002;501:69-78 pubmed
    ..Our data suggest that the DPC method is a useful tool for detecting DNA damage, and DPC formation may be associated with the induction of breast cancer. ..
  5. Mansour H, Talkowski M, Wood J, Chowdari K, McClain L, Prasad K, et al. Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia. Bipolar Disord. 2009;11:701-10 pubmed publisher
    ..5. Additional analyses using adequately powered samples are warranted to further evaluate these results. ..
  6. Pereira D, Pedrazzoli M, Koike B, Louzada F, Benedito Silva A, Lopez A, et al. The G619A Aa-nat gene polymorphism does not contribute to sleep time variation in the Brazilian population. Behav Genet. 2007;37:637-8 pubmed
    ..frequencies of the 619A allele of the G619A Aa-nat gene polymorphism in a sample of Delayed Sleep Phase Syndrome (DSPS) patients...
  7. Kang K, Lee K, Park S, Kim Y, Back K. Enhanced production of melatonin by ectopic overexpression of human serotonin N-acetyltransferase plays a role in cold resistance in transgenic rice seedlings. J Pineal Res. 2010;49:176-82 pubmed publisher
    ..Finally, the transgenic rice seedlings with high levels of melatonin showed elevated chlorophyll synthesis during cold stress, suggesting a role for melatonin in cold-stress resistance. ..
  8. Shimozuma M, Tokuyama R, Tatehara S, Umeki H, Ide S, Mishima K, et al. Expression and cellular localizaion of melatonin-synthesizing enzymes in rat and human salivary glands. Histochem Cell Biol. 2011;135:389-96 pubmed publisher
    ..by various extrapineal organs, tissues and cells and its synthesizing enzyme arylalkylamine N-acetyltransferase (AANAT) is expressed in various extrapineal organs, tissues and cells...
  9. Liu J, Lemonds T, Marden J, POPADIC A. A Pathway Analysis of Melanin Patterning in a Hemimetabolous Insect. Genetics. 2016;203:403-13 pubmed publisher
    ..Here we provide a comprehensive analysis of how a set of melanin genes (ebony, black, aaNAT, yellow, and tan) contributes to the pigmentation pattern in a hemipteran, Oncopeltus fasciatus For all five genes,..
  10. Ganguly S, Gastel J, Weller J, Schwartz C, Jaffe H, Namboodiri M, et al. Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis. Proc Natl Acad Sci U S A. 2001;98:8083-8 pubmed
    ..by cAMP through actions on the penultimate enzyme in melatonin synthesis, arylalkylamine N-acetyltransferase (AANAT; serotonin N-acetyltransferase, EC )...

Detail Information

Publications44

  1. Coon S, Mazuruk K, Bernard M, Roseboom P, Klein D, Rodriguez I. The human serotonin N-acetyltransferase (EC 2.3.1.87) gene (AANAT): structure, chromosomal localization, and tissue expression. Genomics. 1996;34:76-84 pubmed
    Serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AA-NAT, HGMW-approved symbol AANAT; EC 2.3.1...
  2. Wang C, Jones R, Debiec Rychter M, Soos G, Haas G. Correlation of the genotypes for N-acetyltransferases 1 and 2 with double bladder and prostate cancers in a case-comparison study. Anticancer Res. 2002;22:3529-35 pubmed
    ..13 of 34 controls (odds ratio 3.88; p = 0.040). Rapid NAT2 genotype correlated significantly with the development of double prostate-bladder cancer. ..
  3. Soria V, Martínez Amorós E, Escaramis G, Valero J, Crespo J, Gutierrez Zotes A, et al. Resequencing and association analysis of arylalkylamine N-acetyltransferase (AANAT) gene and its contribution to major depression susceptibility. J Pineal Res. 2010;49:35-44 pubmed publisher
    ..Arylalkylamine N-acetyltransferase (AANAT) is a key enzyme of the melatonin pathway involved in circadian oscillations of melatonin levels...
  4. Wu F, Lee Y, Chen D, Kuo H. Association of DNA-protein crosslinks and breast cancer. Mutat Res. 2002;501:69-78 pubmed
    ..Our data suggest that the DPC method is a useful tool for detecting DNA damage, and DPC formation may be associated with the induction of breast cancer. ..
  5. Mansour H, Talkowski M, Wood J, Chowdari K, McClain L, Prasad K, et al. Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia. Bipolar Disord. 2009;11:701-10 pubmed publisher
    ..5. Additional analyses using adequately powered samples are warranted to further evaluate these results. ..
  6. Pereira D, Pedrazzoli M, Koike B, Louzada F, Benedito Silva A, Lopez A, et al. The G619A Aa-nat gene polymorphism does not contribute to sleep time variation in the Brazilian population. Behav Genet. 2007;37:637-8 pubmed
    ..frequencies of the 619A allele of the G619A Aa-nat gene polymorphism in a sample of Delayed Sleep Phase Syndrome (DSPS) patients...
  7. Kang K, Lee K, Park S, Kim Y, Back K. Enhanced production of melatonin by ectopic overexpression of human serotonin N-acetyltransferase plays a role in cold resistance in transgenic rice seedlings. J Pineal Res. 2010;49:176-82 pubmed publisher
    ..Finally, the transgenic rice seedlings with high levels of melatonin showed elevated chlorophyll synthesis during cold stress, suggesting a role for melatonin in cold-stress resistance. ..
  8. Shimozuma M, Tokuyama R, Tatehara S, Umeki H, Ide S, Mishima K, et al. Expression and cellular localizaion of melatonin-synthesizing enzymes in rat and human salivary glands. Histochem Cell Biol. 2011;135:389-96 pubmed publisher
    ..by various extrapineal organs, tissues and cells and its synthesizing enzyme arylalkylamine N-acetyltransferase (AANAT) is expressed in various extrapineal organs, tissues and cells...
  9. Liu J, Lemonds T, Marden J, POPADIC A. A Pathway Analysis of Melanin Patterning in a Hemimetabolous Insect. Genetics. 2016;203:403-13 pubmed publisher
    ..Here we provide a comprehensive analysis of how a set of melanin genes (ebony, black, aaNAT, yellow, and tan) contributes to the pigmentation pattern in a hemipteran, Oncopeltus fasciatus For all five genes,..
  10. Ganguly S, Gastel J, Weller J, Schwartz C, Jaffe H, Namboodiri M, et al. Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis. Proc Natl Acad Sci U S A. 2001;98:8083-8 pubmed
    ..by cAMP through actions on the penultimate enzyme in melatonin synthesis, arylalkylamine N-acetyltransferase (AANAT; serotonin N-acetyltransferase, EC )...
  11. Obsil T, Ghirlando R, Klein D, Ganguly S, Dyda F. Crystal structure of the 14-3-3zeta:serotonin N-acetyltransferase complex. a role for scaffolding in enzyme regulation. Cell. 2001;105:257-67 pubmed
    Serotonin N-acetyltransferase (AANAT) controls the daily rhythm in melatonin synthesis. When isolated from tissue, AANAT copurifies with isoforms epsilon and zeta of 14-3-3...
  12. Smith T. Phylogenetic distribution and function of arylalkylamine N-acetyltransferase. Bioessays. 1990;12:30-3 pubmed
    ..In insects, this enzyme is involved in monoamine neurotransmitter inactivation and the formation of catecholamine intermediates necessary for sclerotization of the insect cuticle. ..
  13. Takahashi Y, Nishimura T, Maruyama T, Tomi M, Nakashima E. Contributions of system A subtypes to α-methylaminoisobutyric acid uptake by placental microvillous membranes of human and rat. Amino Acids. 2017;49:795-803 pubmed publisher
    ..Appropriate concentrations of betaine and L-arginine for subtype-selective inhibition in SNAT-overexpressing cells were identified...
  14. Coon S, Roseboom P, Baler R, Weller J, Namboodiri M, Koonin E, et al. Pineal serotonin N-acetyltransferase: expression cloning and molecular analysis. Science. 1995;270:1681-3 pubmed
    ..The night-to-day ratio of ovine pineal AA-NAT mRNA is less than 2. In contrast, the ratio exceeds 150 in rats. AA-NAT represents a family within a large superfamily of acetyltransferases. ..
  15. Masuoka Y, Maekawa K. Gene expression changes in the tyrosine metabolic pathway regulate caste-specific cuticular pigmentation of termites. Insect Biochem Mol Biol. 2016;74:21-31 pubmed publisher
    ..On the other hand, high expression levels of yellow and aaNAT were observed during worker and presoldier molts, respectively, but most other genes in the pathway were expressed ..
  16. Han Y, Demorrow S, Invernizzi P, Jing Q, Glaser S, Renzi A, et al. Melatonin exerts by an autocrine loop antiproliferative effects in cholangiocarcinoma: its synthesis is reduced favoring cholangiocarcinoma growth. Am J Physiol Gastrointest Liver Physiol. 2011;301:G623-33 pubmed publisher
    ..in the pineal gland and peripheral organs from serotonin by two enzymes, serotonin N-acetyltransferase (AANAT) and acetylserotonin O-methyltransferase (ASMT)...
  17. Gu Q, Chen Z, Yu X, Cui W, Pan J, Zhao G, et al. Melatonin confers plant tolerance against cadmium stress via the decrease of cadmium accumulation and reestablishment of microRNA-mediated redox homeostasis. Plant Sci. 2017;261:28-37 pubmed publisher
    ..The melatonin-rich transgenic Arabidopsis plants overexpressing alfalfa SNAT (a melatonin synthetic gene) exhibited more tolerance than wild-type plants under Cd conditions...
  18. Alkozi H, Pérez de Lara M, Pintor J. Melatonin synthesis in the human ciliary body triggered by TRPV4 activation: Involvement of AANAT phosphorylation. Exp Eye Res. 2017;162:1-8 pubmed publisher
    ..two enzymes, the first limiting step into the synthesis of melatonin being aralkylamine N-acetyltransferase (AANAT)...
  19. Liu L, Jiang G, Peng Z, Li Y, Li J, Zou L, et al. The effect of high fat diet on daily rhythm of the core clock genes and muscle functional genes in the skeletal muscle of Chinese soft-shelled turtle (Trionyx sinensis). Comp Biochem Physiol B Biochem Mol Biol. 2017;213:17-27 pubmed publisher
    ..we measured the daily expression levels of 17 core clock genes (Clock, Bmal1/2, NPAS2, Tim, Cry1/2, Per1/2, DBP, AANAT, NIFL3, BHLHE40, NR1D2, RORA, RORB, RORC) and 12 muscle functional genes (FBXO32, MBNL1, MSTN, Myf5, Myf6, MyoD, ..
  20. Lee H, Back K. Cadmium Disrupts Subcellular Organelles, Including Chloroplasts, Resulting in Melatonin Induction in Plants. Molecules. 2017;22: pubmed publisher
    ..In theory, the disruption of chloroplasts enabled chloroplast-expressed serotonin N-acetyltransferase (SNAT) to encounter serotonin in the cytoplasm, leading to the synthesis of N-acetylserotonin followed by ..
  21. Jonsson L, Ljunggren E, Bremer A, Pedersen C, Landen M, Thuresson K, et al. Mutation screening of melatonin-related genes in patients with autism spectrum disorders. BMC Med Genomics. 2010;3:10 pubmed publisher
    ..However, further studies of the novel variants identified in this study are warranted to shed light on their potential role in the pathophysiology of these disorders. ..
  22. Wang H, Wu Z, Zhuang Q, Fei Q, Zhang J, Liu Y, et al. Association study of tryptophan hydroxylase 1 and arylalkylamine N-acetyltransferase polymorphisms with adolescent idiopathic scoliosis in Han Chinese. Spine (Phila Pa 1976). 2008;33:2199-203 pubmed publisher
    A genetic association study of tryptophan hydroxylase 1 gene (TPH1) and arylalkylamine N-acetyltransferase gene(AANAT) with adolescent idiopathic scoliosis (AIS) in Han Chinese...
  23. Klein D. Arylalkylamine N-acetyltransferase: "the Timezyme". J Biol Chem. 2007;282:4233-7 pubmed publisher
    ..This activates the enzyme and prevents proteosomal proteolysis. The conserved features of regulatory systems that control arylalkylamine N-acetyltransferase are a circadian clock and environmental lighting...
  24. Klein D, Coon S, Roseboom P, Weller J, Bernard M, Gastel J, et al. The melatonin rhythm-generating enzyme: molecular regulation of serotonin N-acetyltransferase in the pineal gland. Recent Prog Horm Res. 1997;52:307-57; discussion 357-8 pubmed
    ..The variety of mechanisms that have evolved among vertebrates to achieve the same goal-a rhythm in melatonin-underlines the important role melatonin plays as the hormonal signal of environmental lighting in vertebrates. ..
  25. Sijbesma E, Skora L, Leysen S, Brunsveld L, Koch U, Nussbaumer P, et al. Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening. Biochemistry. 2017;56:3972-3982 pubmed publisher
    ..This first identification of secondary sites on 14-3-3 proteins bound by small molecule ligands might facilitate the development of new chemical tool compounds for more selective PPI modulation. ..
  26. Alkozi H, Pérez de Lara M, Sánchez Navés J, Pintor J. TRPV4 Stimulation Induced Melatonin Secretion by Increasing Arylalkymine N-acetyltransferase (AANAT) Protein Level. Int J Mol Sci. 2017;18: pubmed publisher
    ..from serotonin in two steps, with a rate-limiting step carried out by arylalkymine N-acetyltransferase (AANAT)...
  27. Achterberg M, van Duijvenvoorde A, Van der Meulen M, Euser S, Bakermans Kranenburg M, Crone E. The neural and behavioral correlates of social evaluation in childhood. Dev Cogn Neurosci. 2017;24:107-117 pubmed publisher
    ..of social feedback and subsequent aggression in 7-10-year-old children, using the Social Network Aggression Task (SNAT)...
  28. Gu F, Zhang H, Hyland P, Berndt S, Gapstur S, Wheeler W, et al. Inherited variation in circadian rhythm genes and risks of prostate cancer and three other cancer sites in combined cancer consortia. Int J Cancer. 2017;141:1794-1802 pubmed publisher
    ..00625). The two most significant genes were NPAS2 (pgene  = 0.0062) and AANAT (pgene  = 0.00078); the latter being significant after Bonferroni correction...
  29. Wadas B, Borjigin J, Huang Z, Oh J, Hwang C, Varshavsky A. Degradation of Serotonin N-Acetyltransferase, a Circadian Regulator, by the N-end Rule Pathway. J Biol Chem. 2016;291:17178-96 pubmed publisher
    Serotonin N-acetyltransferase (AANAT) converts serotonin to N-acetylserotonin (NAS), a distinct biological regulator and the immediate precursor of melatonin, a circulating hormone that influences circadian processes, including sleep...
  30. Hohjoh H, Takasu M, Shishikura K, Takahashi Y, Honda Y, Tokunaga K. Significant association of the arylalkylamine N-acetyltransferase ( AA-NAT) gene with delayed sleep phase syndrome. Neurogenetics. 2003;4:151-3 pubmed
    ..We studied the association between the AA-NAT gene and delayed sleep phase syndrome (DSPS)...
  31. Ying G, Lee C, Lee E. A naturally occurring -263G/C variant of the human AA-NAT gene and overnight melatonin production. Mol Genet Metab. 2004;81:65-9 pubmed
    ..The overnight urinary 6-hydroxymelatonin sulfate (6-OHMS) excretion was quantified by enzyme-linked immunosorbent assay (ELISA). ..
  32. Roseboom P, Weller J, Babila T, Aitken A, Sellers L, Moffett J, et al. Cloning and characterization of the epsilon and zeta isoforms of the 14-3-3 proteins. DNA Cell Biol. 1994;13:629-40 pubmed
    ..This investigation also revealed the epsilon isoform was present at high levels in the rat pineal gland early in development and decreased steadily thereafter and that 30-kD isoforms exhibited the inverse developmental pattern. ..
  33. Huang Y, Liu S, Yuan S, Guan C, Tian D, Cui X, et al. Overexpression of ovine AANAT and HIOMT genes in switchgrass leads to improved growth performance and salt-tolerance. Sci Rep. 2017;7:12212 pubmed publisher
    ..Our study provided valuable findings that melatonin functions as a promoter in the regulation of switchgrass growth, flowering and salt tolerance. ..
  34. Kirsz K, Szczesna M, Molik E, Zieba D. Effects of ghrelin on nocturnal melatonin secretion in sheep: An in vitro and in vivo approach. J Anim Sci. 2017;95:4101-4112 pubmed publisher
    ..These findings indicate that GHRL directly and indirectly affects PG activity in sheep and that the photoperiod modulates the effects of GHRL...
  35. Chapman E, O Dell A, Meligi N, Parsons D, Rotchell J. Seasonal expression patterns of clock-associated genes in the blue mussel Mytilus edulis. Chronobiol Int. 2017;:1-15 pubmed publisher
    ..edulis), using mRNA expression patterns of clock-associated genes: Clock, Cry1¸ ARNT, Timeout-like, ROR/HR3 and aaNAT, in the gonads of both sexes, sampled over three daily time-points on a tidal beach during the winter and summer ..
  36. Anderson B, Schnetz Boutaud N, Bartlett J, Wotawa A, Wright H, Abramson R, et al. Examination of association of genes in the serotonin system to autism. Neurogenetics. 2009;10:209-16 pubmed publisher
    ..These data suggest that variation within genes on the serotonin pathway, particularly HTR3A, may have modest effects on autism risk. ..
  37. Lee K, Lee H, Back K. Rice histone deacetylase 10 and Arabidopsis histone deacetylase 14 genes encode N-acetylserotonin deacetylase, which catalyzes conversion of N-acetylserotonin into serotonin, a reverse reaction for melatonin biosynthesis in plants. J Pineal Res. 2017;: pubmed publisher
    ..present in archaea, but not in cyanobacteria, which differs from the distribution of serotonin N-acetyltransferase (SNAT). This suggests that SNAT and ASDAC may have evolved differently from ancestral eukaryotic cells...
  38. Coon S, Weller J, Korf H, Namboodiri M, Rollag M, Klein D. cAmp regulation of arylalkylamine N-acetyltransferase (AANAT, EC 2.3.1.87): a new cell line (1E7) provides evidence of intracellular AANAT activation. J Biol Chem. 2001;276:24097-107 pubmed
    Arylalkylamine N-acetyltransferase (serotonin N-acetyltransferase, AANAT, EC ) is the penultimate enzyme in melatonin synthesis...
  39. Sekine A, Saito S, Iida A, Mitsunobu Y, Higuchi S, Harigae S, et al. Identification of single-nucleotide polymorphisms (SNPs) of human N-acetyltransferase genes NAT1, NAT2, AANAT, ARD1 and L1CAM in the Japanese population. J Hum Genet. 2001;46:314-9 pubmed
    ..arylamine N-acetyltransferase (NAT1), arylamine N-acetyltransferase (NAT2), arylalkylamine N-acetyltransferase (AANAT), L1 cell adhesion molecule (L1CAM), and the human homolog of Saccharomyces cerevisiae N-acetyltransferase ARD1, ..
  40. Alkozi H, Wang X, Pérez de Lara M, Pintor J. Presence of melanopsin in human crystalline lens epithelial cells and its role in melatonin synthesis. Exp Eye Res. 2017;154:168-176 pubmed publisher
    ..Moreover, studying the concentration of melatonin and its synthesising enzyme AANAT proved a clear link between melanopsin activation and the suppression of melatonin synthesis...
  41. Markowska M, Majewski P, Skwarło Sońta K. Avian biological clock - Immune system relationship. Dev Comp Immunol. 2017;66:130-138 pubmed publisher
    ..production at the level of the key enzyme in its biosynthetic pathway, arylalkylamine-N-acetyltransferase (AANAT)...
  42. Blomeke B, Golka K, Griefahn B, Roemer H. Arylalkylamine N-acetyltransferase (AANAT) genotype as a personal trait in melatonin synthesis. J Toxicol Environ Health A. 2008;71:874-6 pubmed publisher
    ..quot; Arylalkylamine N-acetyltransferase (AANAT) is known to catalyze the acetylation of serotonin, a rate-limiting process in melatonin synthesis...
  43. Slominski A, Pisarchik A, Semak I, Sweatman T, Wortsman J, Szczesniewski A, et al. Serotoninergic and melatoninergic systems are fully expressed in human skin. FASEB J. 2002;16:896-8 pubmed
    ..showed simultaneous expression of the genes for tryptophan hydroxylase, arylalkylamine N-acetyltransferase (AANAT), and hydroxyindole-O-methyltransferase (HIOMT)...
  44. Wang G, Lee C, Lee E. Genetic variability of arylalkylamine-N-acetyl-transferase (AA-NAT) gene and human sleep/wake pattern. Chronobiol Int. 2004;21:229-37 pubmed
    ..The -263G/C SNP may therefore be an important determinant of the late/short sleep pattern. ..