interleukin 4 receptor

Summary

Gene Symbol: interleukin 4 receptor
Description: interleukin 4 receptor
Alias: Il4ra, IL-4 receptor subunit alpha, IL-4R subunit alpha, IL-4R-alpha, IL-4RA, interleukin 4 receptor, alpha, interleukin-4 receptor alpha chain, interleukin-4 receptor subunit alpha
Species: rat

Top Publications

  1. doi IL-4 is proangiogenic in the lung under hypoxic conditions
    Kazuyo Yamaji-Kegan
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
    J Immunol 182:5469-76. 2009
  2. pmc Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma
    Raffi Tachdjian
    Division of Immunology, Allergy, and Rheumatology, Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    J Exp Med 206:2191-204. 2009
  3. doi Interleukin-4 receptor polymorphisms in asthma and allergy: relation to different disease phenotypes
    B Hesselmar
    Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg, Sweden
    Acta Paediatr 99:399-403. 2010
  4. pmc Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma
    Timothy D Howard
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Hum Genet 70:230-6. 2002
  5. ncbi V75R576 IL-4 receptor alpha is associated with allergic asthma and enhanced IL-4 receptor function
    Kimberly A Risma
    Division of Allergy and Immunology, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Immunol 169:1604-10. 2002
  6. pmc IL4R alpha mutations are associated with asthma exacerbations and mast cell/IgE expression
    Sally E Wenzel
    University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Respir Crit Care Med 175:570-6. 2007
  7. ncbi Haplotypes of the interleukin-4 receptor alpha chain gene associate with susceptibility to and severity of atopic asthma
    A M Hytönen
    Department of Clinical Immunology, Sahlgrenska University Hospital, University of Goteborg, Goteborg, Sweden
    Clin Exp Allergy 34:1570-5. 2004
  8. ncbi Association of severe respiratory syncytial virus bronchiolitis with interleukin-4 and interleukin-4 receptor alpha polymorphisms
    Barbara Hoebee
    Laboratory for Health Effects Research, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    J Infect Dis 187:2-11. 2003
  9. ncbi Polymorphisms in the IL-4 and IL-4R [alpha] genes and allergic asthma
    Tianpen Cui
    Immunology Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P R of China
    Clin Chem Lab Med 41:888-92. 2003
  10. ncbi Interleukin-4-receptor alpha gene polymorphism and the risk of renal cell carcinoma in a South Indian population
    Shruthi Mohan
    Department of Human Genetics, Sri Ramachandra University, Chennai, Tamil Nadu, India
    Asian Pac J Cancer Prev 10:295-8. 2009

Scientific Experts

  • Tian pen Cui
  • Louis N Irwin
  • Kathleen M Eyster
  • Ann Marie Bergin
  • B Hesselmar
  • Sally Wenzel
  • Barbara Hoebee
  • D B Mirel
  • M Arvidsson
  • M J Loza
  • Raj K Puri
  • H Chu
  • Armando Mendez
  • Frank Kirstein
  • Xiaobo Li
  • Anna Kaminski
  • Guilan Wang
  • Seung Ihm Lee
  • K A Shirey
  • Michael J Ripple
  • Sabrina Shandley
  • Andrea Formentini
  • Shruthi Mohan
  • Raffi Tachdjian
  • Kazuyo Yamaji-Kegan
  • Frank Brombacher
  • Isabel C J de Faria
  • Kazunori Ishige
  • Uwe Muller
  • Kin Wai Lai
  • Takeshi Shimamura
  • Charles Perkins
  • A M Hytönen
  • Bernd Woitsch
  • Claudia Jakubzick
  • Kimberly A Risma
  • Eijiro Nakamura
  • Timothy D Howard
  • M Wang
  • H Hackstein
  • C P Leo
  • F Yan
  • L C Borish
  • D L Radu
  • D Zhong
  • Z Zhang
  • C Qin
  • D Shi
  • C Yin
  • L Ma
  • X Pan
  • Diana Aguilar
  • Rogelio Hernandez-Pando
  • Graham A W Rook
  • Salvador Contreras
  • Yao Deng
  • William G C Horsnell
  • Jirong Lu
  • A C Puche
  • A D Keegan
  • Jin Huang
  • L M Pletneva
  • Noel G Morgan
  • Byung Kwan Jin
  • Soo Ryeong Jeong
  • Chao He
  • Uk Namgung
  • Dae Hee Han
  • Yonggang Zhang
  • Y Z Zhu
  • David M Becnel
  • Young Mi Kang
  • Andrew B Sewell
  • Natalie Nieuwenhuizen
  • Stephania A Cormier
  • S N Vogel
  • J G van den Berg
  • Yingying Yang
  • Srinivasa Honnegowda
  • G A Prince
  • J C G Blanco
  • Hannah J Welters
  • Bernhard Ryffel
  • Jie Zhang
  • Can Tian
  • Edward R Kaminski
  • Yuling Xiao
  • Hong Fan
  • Byung G Kim
  • Dahui You

Detail Information

Publications44

  1. doi IL-4 is proangiogenic in the lung under hypoxic conditions
    Kazuyo Yamaji-Kegan
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
    J Immunol 182:5469-76. 2009
    ..In conclusion, IL-4 has proangiogenic properties in the lung under hypoxic conditions via the VEGF pathway, and this is independent of the STAT6 pathway...
  2. pmc Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma
    Raffi Tachdjian
    Division of Immunology, Allergy, and Rheumatology, Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    J Exp Med 206:2191-204. 2009
    ..Our findings indicate that the Q576R polymorphism directly promotes asthma in carrier populations by selectively augmenting IL-4R alpha-dependent signaling...
  3. doi Interleukin-4 receptor polymorphisms in asthma and allergy: relation to different disease phenotypes
    B Hesselmar
    Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg, Sweden
    Acta Paediatr 99:399-403. 2010
    ..We tested if single nucleotide polymorphisms (SNPs) in the IL4R gene were associated with susceptibility to such diseases, or if they were related to the phenotypic presentation of asthma and allergic rhinoconjunctivitis (ARC)...
  4. pmc Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma
    Timothy D Howard
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Hum Genet 70:230-6. 2002
    ..These cytokines also share a common receptor component, IL4R alpha. We have investigated five IL4RA single-nucleotide polymorphisms in a population of Dutch families ascertained through a proband with asthma...
  5. ncbi V75R576 IL-4 receptor alpha is associated with allergic asthma and enhanced IL-4 receptor function
    Kimberly A Risma
    Division of Allergy and Immunology, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Immunol 169:1604-10. 2002
    ..These data illustrate the importance of studying snps in combination, because the functional significance of a given snp may only be evident in a specific setting of additional snps in the same or different genes...
  6. pmc IL4R alpha mutations are associated with asthma exacerbations and mast cell/IgE expression
    Sally E Wenzel
    University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Respir Crit Care Med 175:570-6. 2007
    ..However, an effect on exacerbations and tissue inflammation has not been shown...
  7. ncbi Haplotypes of the interleukin-4 receptor alpha chain gene associate with susceptibility to and severity of atopic asthma
    A M Hytönen
    Department of Clinical Immunology, Sahlgrenska University Hospital, University of Goteborg, Goteborg, Sweden
    Clin Exp Allergy 34:1570-5. 2004
    ..Several groups have suggested the gene of the IL-4 receptor alpha chain (IL4R) as a candidate gene for the development of asthma, although association with single polymorphisms has shown contradicting results...
  8. ncbi Association of severe respiratory syncytial virus bronchiolitis with interleukin-4 and interleukin-4 receptor alpha polymorphisms
    Barbara Hoebee
    Laboratory for Health Effects Research, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    J Infect Dis 187:2-11. 2003
    ..These results indicate that gain-of-function variants of T helper type 2 cytokine genes may play a role in increasing the severity of RSV disease, which appears more pronounced after the first half-year of life...
  9. ncbi Polymorphisms in the IL-4 and IL-4R [alpha] genes and allergic asthma
    Tianpen Cui
    Immunology Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P R of China
    Clin Chem Lab Med 41:888-92. 2003
    ..16; p < 0.01), and also total plasma immunoglobulin E (IgE) level was increased in allergic asthma patients. These data suggest that the IL-4R alpha chain 576R/R genotypes confer genetic susceptibility to allergic asthma in Chinese...
  10. ncbi Interleukin-4-receptor alpha gene polymorphism and the risk of renal cell carcinoma in a South Indian population
    Shruthi Mohan
    Department of Human Genetics, Sri Ramachandra University, Chennai, Tamil Nadu, India
    Asian Pac J Cancer Prev 10:295-8. 2009
    ..Stratified analysis based on the genotypes and the stage of tumor revealed no significant association. Thus, the present study indicates that IL4Ralpha could be a candidate gene for assessing the risk of RCC...
  11. pmc Novel odors affect gene expression for cytokines and proteinases in the rat amygdala and hippocampus
    Louis N Irwin
    Department of Biological Sciences, University of Texas at El Paso, Texas 79968, USA
    Brain Res 1489:1-7. 2012
    ..This suggests considerable variation in the way that olfactory information is processed at the cellular level in different brain regions and by the two sexes...
  12. ncbi Genetic polymorphisms of the interleukin-4 receptor alpha gene are associated with an increasing risk and a poor prognosis of sporadic renal cell carcinoma in a Japanese population
    Eijiro Nakamura
    Department of Urology, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    Clin Cancer Res 8:2620-5. 2002
    ..The significance of the polymorphisms on the incidence and prognosis in sporadic RCC patients were examined to clarify the role of IL-4 as well as that of the Th1/Th2 immune system in this disease...
  13. doi Polymorphisms in the IL-13 and IL-4R genes are associated with the development of renal cell carcinoma
    H Chu
    State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Department of Molecular and Genetic Toxicology, School of Public Health, Nanjing Medical University, and Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
    Ann Oncol 23:2114-21. 2012
    ..It has been suggested that the imbalance of immune system of the host might affect the generation of diseases, including cancers...
  14. doi Potent in vitro and in vivo antitumor activity of interleukin-4-conjugated Pseudomonas exotoxin against human biliary tract carcinoma
    Kazunori Ishige
    Department of Gastroenterology, Institute of Clinical Medicine, University of Tsukuba Graduate School of Comprehensive Human Sciences, Tsukuba shi, Ibaraki, Japan
    Int J Cancer 123:2915-22. 2008
    ..5 weeks in treated and untreated mice, respectively). These results indicate that IL-4 receptor-targeted cytotoxin is a potent agent that may provide a new therapeutic option for BTC...
  15. doi A gene-dosage effect for interleukin-4 receptor alpha-chain expression has an impact on Th2-mediated allergic inflammation during bronchopulmonary mycosis
    Uwe Muller
    Institute of Immunology, College of Veterinary Medicine, University of Leipzig, An den Tierkliniken 11, Leipzig, Germany
    J Infect Dis 198:1714-21. 2008
    ..mice and no expression in IL-4Ralpha(-/-) mice, indicating biallelic expression of the gene for IL-4Ralpha (Il4ra)...
  16. pmc IL-4 receptor as a bridge between the immune system and muscle in experimental myasthenia gravis I: up-regulation of muscle IL-15 by IL-4
    Sabrina Shandley
    Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Clin Immunol 132:246-56. 2009
    ..A model is proposed in which these muscle activities participate in disease progression in experimental myasthenia gravis...
  17. doi Human and rodent pancreatic beta-cells express IL-4 receptors and IL-4 protects against beta-cell apoptosis by activation of the PI3K and JAK/STAT pathways
    Anna Kaminski
    Institute of Biomedical and Clinical Science, John Bull Building, Peninsula Medical School, Plymouth, Devon PL6 8BU, UK
    Biosci Rep 30:169-75. 2010
    ..These findings may have implications for future therapeutic strategies for the management of diabetes...
  18. doi Endogenous expression of interleukin-4 regulates macrophage activation and confines cavity formation after traumatic spinal cord injury
    Seung Ihm Lee
    Brain Disease Research Center, Institute for Medical Sciences, and Department of Neurology, Ajou University School of Medicine, Suwon, Republic of Korea
    J Neurosci Res 88:2409-19. 2010
    ..These results suggest that endogenous expression of antiinflammatory cytokine IL-4 regulates the extent of acute macrophage activation and confines the ensuing secondary cavity formation after spinal cord trauma...
  19. doi CCL2, CCL18 and sIL-4R in renal, meningeal and pulmonary TB; a 2 year study of patients and contacts
    Armando Mendez
    Universidad Veracruzana, Xalapa, Veracruz, Mexico
    Tuberculosis (Edinb) 91:140-5. 2011
    ..However contacts had raised expression of IL-4δ2 as previously found. These results indicate vigorous and previously unrecorded activity within the Th2 axis, and further investigation is warranted...
  20. doi Retrovirus-mediated delivery of an IL-4 receptor antagonist inhibits allergic responses in a murine model of asthma
    Guilan Wang
    Department of Pediatrics, Zhongshan Boai Hospital, Zhongshan, China
    Sci China Life Sci 53:1215-20. 2010
    ..This suggests that gene therapy is a therapeutic option for treating and controlling chronic airway inflammation and asthma symptoms...
  21. pmc Control of RSV-induced lung injury by alternatively activated macrophages is IL-4R alpha-, TLR4-, and IFN-beta-dependent
    K A Shirey
    Department of Microbiology and Immunology, University of Maryland, Baltimore UMB, Baltimore, MD, USA
    Mucosal Immunol 3:291-300. 2010
    ..RSV-infected cotton rats treated with a cyclooxygenase-2 inhibitor increased expression of lung AA-M phi. These data suggest new treatment strategies for RSV that promote AA-M phi differentiation...
  22. pmc Asthma susceptible genes in Chinese population: a meta-analysis
    Xiaobo Li
    Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China
    Respir Res 11:129. 2010
    ..Published data regarding the associations between genetic variants and asthma risk in Chinese population were inconclusive. The aim of this study was to investigate asthma susceptible genes in Chinese population...
  23. pmc Immunomodulation with IL-4R alpha antisense oligonucleotide prevents respiratory syncytial virus-mediated pulmonary disease
    Michael J Ripple
    Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    J Immunol 185:4804-11. 2010
    ....
  24. pmc Anisakis pegreffii-induced airway hyperresponsiveness is mediated by gamma interferon in the absence of interleukin-4 receptor alpha responsiveness
    Frank Kirstein
    Division of Immunology, Institute of Infectious Disease and Molecular Medicine, Health Sciences Faculty, University of Cape Town and International Centre for Genetic Engineering and Biotechnology ICGEB, 7925 Cape Town, South Africa
    Infect Immun 78:4077-86. 2010
    ..Importantly for diagnosis, allergic airway inflammation can be independent of detectable Anisakis-specific antibodies. Moreover, depending on the route of sensitization, AHR can be induced either by IL-4/IL-13 or by IFN-gamma...
  25. doi Interleukin-13 exerts autocrine growth-promoting effects on human pancreatic cancer, and its expression correlates with a propensity for lymph node metastases
    Andrea Formentini
    Clinic of General, Visceral, and Transplantation Surgery, University of Ulm, Steinhoevelstrasse 9, 89075, Ulm, Germany
    Int J Colorectal Dis 24:57-67. 2009
    ..It is not known whether pancreatic cancer cells produce IL-13 or whether IL-13 can modulate pancreatic cancer cell growth and influence the frequency of lymph node metastases...
  26. doi Association of TGF-beta1, CD14, IL-4, IL-4R and ADAM33 gene polymorphisms with asthma severity in children and adolescents
    Isabel C J de Faria
    Departamento de Genetica, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, Campinas, SP
    J Pediatr (Rio J) 84:203-10. 2008
    ....
  27. ncbi Interleukin-4 cytotoxin therapy synergizes with gemcitabine in a mouse model of pancreatic ductal adenocarcinoma
    Takeshi Shimamura
    Tumor Vaccines and Biotechnology Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, NIH, Bethesda, MD 20892, USA
    Cancer Res 67:9903-12. 2007
    ..These results indicate that IL-4 cytotoxin combined with gemcitabine may provide effective therapy for the treatment of patients with PDA...
  28. ncbi Interleukin-4 and interleukin-13 act on glomerular visceral epithelial cells
    J G van den Berg
    Department of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Am Soc Nephrol 11:413-22. 2000
    ..It is concluded that by binding to specific IL-4/ IL-13 receptors, IL-4 and IL-13 can exert specific effects on GVEC function, which could be of pathogenetic relevance for glomerular injury in MCN...
  29. ncbi Identification of regulated genes in rat heart after myocardial infarction by means of differential mRNA display
    Y Z Zhu
    Department of Pharmacology, Christian Albrechts University of Kiel, Germany
    Jpn Heart J 41:59-66. 2000
    ..The remaining clones have no similarity to known sequences. These data suggest that certain genes which were not previously being associated with cardiac hypertrophy are turned on during the process of cardiac remodeling after MI...
  30. ncbi Analysis of interleukin-4 receptor alpha chain variants in multiple sclerosis
    H Hackstein
    Institute of Clinical Immunology and Transfusion Medicine, Justus Liebig University, Langhansstrasse 7, D 35392, Giessen, Germany
    J Neuroimmunol 113:240-8. 2001
    ..These results indicate, that the IL4R variant R551 may influence the genetic predisposition for PPMS but does not represent a general genetic risk factor for MS...
  31. ncbi Efficacy of soluble IL-4 receptor for the treatment of adults with asthma
    L C Borish
    National Jewish Medical and Research Center, University of Colorado, Health Sciences Center, Denver, CO, USA
    J Allergy Clin Immunol 107:963-70. 2001
    ....
  32. ncbi DNA array analysis of changes in preovulatory gene expression in the rat ovary
    C P Leo
    Division of Reproductive Biology, Department of Gynecology and Obstetrics, Stanford University Medical Center, Stanford, California 94305 5317, USA
    Biol Reprod 65:269-76. 2001
    ..These results demonstrate that DNA arrays can be used to identify genes regulated during the periovulatory period, thus contributing to a more detailed understanding of the molecular mechanisms of ovulation...
  33. ncbi Cellular mechanisms involved in experimental insulin-dependent diabetes mellitus
    D L Radu
    Cantacuzino Institute, Department of Immunology Bucharest, Romania
    Roum Arch Microbiol Immunol 60:203-26. 2001
    ..These studies demonstrate that TCR-HA, INS-HA double transgenic mice may provide a useful model to evaluate new strategies for the prevention of diabetes...
  34. ncbi The rat interleukin 4 receptor: coevolution of ligand and receptor
    G Richter
    Institute of Immunology, Klinikum Steglitz, Free University, Berlin, Germany
    Cytokine 7:237-41. 1995
    A rat interleukin 4 receptor (IL-4R) cDNA was cloned by polymerase chain reaction (PCR) using RNA of Con A activated T cells and primers deduced from mouse and human IL-4R sequences...
  35. ncbi Analysis of IL4R haplotypes in predisposition to multiple sclerosis
    D B Mirel
    Department of Human Genetics, Roche Molecular Systems, Alameda, CA 94501, USA
    Genes Immun 5:138-41. 2004
    ..009). These findings suggest a potentially important role for the IL4R gene in predisposition to MS, and provide further evidence of its relevance as a candidate gene for immune-related diseases...
  36. pmc Human pulmonary fibroblasts exhibit altered interleukin-4 and interleukin-13 receptor subunit expression in idiopathic interstitial pneumonia
    Claudia Jakubzick
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0602, USA
    Am J Pathol 164:1989-2001. 2004
    ....
  37. ncbi A comprehensive analysis of interleukin-4 receptor polymorphisms and their association with atopy and IgE regulation in childhood
    Bernd Woitsch
    University Children s Hospital Munich, Munich, Germany
    Int Arch Allergy Immunol 135:319-24. 2004
    ..Numerous polymorphisms have been identified in the coding region of the IL4 receptor alpha chain (IL4Ra) and previous association studies have shown conflicting results...
  38. ncbi IL-4 induces IL-13-independent allergic airway inflammation
    Charles Perkins
    Division of Immunology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    J Allergy Clin Immunol 118:410-9. 2006
    ..The nonredundant role of IL-13 could reflect unique IL-13 activation of a signaling pathway, inhibitory effects induced by IL-4 but not IL-13, or greater production-potency of IL-13 than IL-4...
  39. ncbi Common variations in the IL4R gene affect splicing and influence natural expression of the soluble isoform
    Ann Marie Bergin
    Department of Clinical Immunology, Sahlgrenska University Hospital, Goteborg University, Goteborg, Sweden
    Hum Mutat 27:990-8. 2006
    We previously found the soluble interleukin 4 receptor (sIL4R) to be differently expressed in allergic asthma patients compared to healthy individuals. Here we present data demonstrating the involvement of the sequence variations, c...
  40. ncbi Overexpression of interleukin-13 induces minimal-change-like nephropathy in rats
    Kin Wai Lai
    Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    J Am Soc Nephrol 18:1476-85. 2007
    ....
  41. ncbi Association between Q551R IL4R genetic variants and atopic asthma risk demonstrated by meta-analysis
    Matthew J Loza
    Department of Internal Medicine, Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    J Allergy Clin Immunol 120:578-85. 2007
    ..However, the results from studies testing for associations of the I50V and Q551R IL4R genetic variants are conflicting...
  42. pmc The effects of estrogen and testosterone on gene expression in the rat mesenteric arteries
    Kathleen M Eyster
    Division of Basic Biomedical Science, Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069, USA
    Vascul Pharmacol 47:238-47. 2007
    ..3 alpha-hydroxysteroid dehydrogenase, interleukin 4 receptor, JunB and c-Fos expression were increased by estrogen but not by testosterone...
  43. ncbi Identification of soluble interleukin-4 receptor in rat glomerular epithelial cells(1)
    G Chen
    Department of Molecular Pathology, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakaecho, Itabashi ku, Tokyo, Japan
    Biochim Biophys Acta 1452:79-88. 1999
    ..By using this recombinant sIL-4R, we proved that sIL-4R can antagonize the IL-4-induced proliferation of spleen cells. Present study demonstrated that sIL-4R is expressed in kidney cells and antagonistically functional...

Research Grants4

  1. Inflammation of Myofibroblasts and Loss of Elastic Recoil in Severe Asthma
    Sally E Wenzel; Fiscal Year: 2010
    ..Completing these aims should lead to an improved understanding of the contribution of inflammation and injury repair in the small airways/alveoli to the development of severe asthma. These findings may improve therapy as well. ..
  2. Gene Expession in Conditioned Taste Aversion
    Louis Irwin; Fiscal Year: 2002
    ..As such, it represents a more realistic view of the way in which a system as complex as the brain likely processes and encodes experiential information. ..
  3. TGF-BETA AND MATRIX METALLOPROTEINASES IN AIRWAY REPAIR
    Sally Wenzel; Fiscal Year: 2002
    ..abstract_text> ..
  4. Th2 effects on eicosanoid pathways: implications for altered innate responses in
    Sally E Wenzel; Fiscal Year: 2010
    ..These three aims should provide new insights into how relationships between innate and adaptive/allergic immune responses influence inflammatory/repair, and finally clinical outcomes in chronic and acute asthma. ..