CFTR

Summary

Gene Symbol: CFTR
Description: cystic fibrosis transmembrane conductance regulator
Alias: ABCC7, cystic fibrosis transmembrane conductance regulator, ATP-binding cassette sub-family C member 7, Channel conductance-controlling ATPase, cAMP-dependent chloride channel, cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7)
Species: domestic ferret

Top Publications

  1. Sehgal A, Presente A, Engelhardt J. Developmental expression patterns of CFTR in ferret tracheal surface airway and submucosal gland epithelia. Am J Respir Cell Mol Biol. 1996;15:122-31 pubmed publisher
    Submucosal glands are a major site of cystic fibrosis transmembrane conductance regulator (CFTR) expression in the human airway and may play an important role in the pathogenesis of cystic fibrosis...
  2. Sun X, Olivier A, Liang B, Yi Y, Sui H, Evans T, et al. Lung phenotype of juvenile and adult cystic fibrosis transmembrane conductance regulator-knockout ferrets. Am J Respir Cell Mol Biol. 2014;50:502-12 pubmed publisher
    ..These findings demonstrate that CF ferrets develop lung disease during the juvenile and adult stages that is similar to patients with CF, and suggest that enteric bacterial flora may seed the lung of CF ferrets. ..
  3. Sun X, Olivier A, Yi Y, Pope C, Hayden H, Liang B, et al. Gastrointestinal pathology in juvenile and adult CFTR-knockout ferrets. Am J Pathol. 2014;184:1309-22 pubmed publisher
    Cystic fibrosis (CF) is a multiorgan disease caused by loss of a functional cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel in many epithelia of the body...

Detail Information

Publications3

  1. Sehgal A, Presente A, Engelhardt J. Developmental expression patterns of CFTR in ferret tracheal surface airway and submucosal gland epithelia. Am J Respir Cell Mol Biol. 1996;15:122-31 pubmed publisher
    Submucosal glands are a major site of cystic fibrosis transmembrane conductance regulator (CFTR) expression in the human airway and may play an important role in the pathogenesis of cystic fibrosis...
  2. Sun X, Olivier A, Liang B, Yi Y, Sui H, Evans T, et al. Lung phenotype of juvenile and adult cystic fibrosis transmembrane conductance regulator-knockout ferrets. Am J Respir Cell Mol Biol. 2014;50:502-12 pubmed publisher
    ..These findings demonstrate that CF ferrets develop lung disease during the juvenile and adult stages that is similar to patients with CF, and suggest that enteric bacterial flora may seed the lung of CF ferrets. ..
  3. Sun X, Olivier A, Yi Y, Pope C, Hayden H, Liang B, et al. Gastrointestinal pathology in juvenile and adult CFTR-knockout ferrets. Am J Pathol. 2014;184:1309-22 pubmed publisher
    Cystic fibrosis (CF) is a multiorgan disease caused by loss of a functional cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel in many epithelia of the body...