TNF

Summary

Gene Symbol: TNF
Description: tumor necrosis factor
Alias: TNF-a, TNF-alpha, TNFa, tumor necrosis factor, cachectin, tumor necrosis factor alpha, tumor necrosis factor ligand superfamily member 2
Species: cow
Products:     TNF

Top Publications

  1. Konnai S, Usui T, Ikeda M, Kohara J, Hirata T, Okada K, et al. Tumor necrosis factor-alpha genetic polymorphism may contribute to progression of bovine leukemia virus-infection. Microbes Infect. 2006;8:2163-71 pubmed
    In a previous report, we had indicated that in a sheep model, the expression of tumor necrosis factor (TNF)-alpha was closely associated with disease progression in sheep experimentally infected with bovine leukemia virus (BLV)...
  2. Sadri H, Bruckmaier R, Rahmani H, Ghorbani G, Morel I, van Dorland H. Gene expression of tumour necrosis factor and insulin signalling-related factors in subcutaneous adipose tissue during the dry period and in early lactation in dairy cows. J Anim Physiol Anim Nutr (Berl). 2010;94:e194-202 pubmed publisher
    ..mRNA was quantified by real-time reverse transcription polymerase chain reaction for tumour necrosis factor alpha (TNFα), insulin-independent glucose transporter (GLUT1), insulin-responsive glucose transporter (GLUT4), insulin ..
  3. Hojo T, ODA A, Lee S, Acosta T, Okuda K. Effects of tumor necrosis factor α and Interferon γ on the viability and mRNA expression of TNF receptor type I in endothelial cells from the bovine corpus luteum. J Reprod Dev. 2010;56:515-9 pubmed
    ..We previously reported that a treatment combining tumor necrosis factor α (TNF) and interferon γ (IFNG) induced cell death in LSCs and that LECs express TNF receptor type I (..
  4. Anderson H, Rahmutula D, Gardner D. Tumor necrosis factor-alpha inhibits endothelial nitric-oxide synthase gene promoter activity in bovine aortic endothelial cells. J Biol Chem. 2004;279:963-9 pubmed
    b>Tumor necrosis factor-alpha (TNF-alpha) has been shown to reduce endothelial nitric-oxide synthase (eNOS) gene expression through post-transcriptional regulation of mRNA stability...
  5. Sohn E, Paape M, Connor E, Bannerman D, Fetterer R, Peters R. Bacterial lipopolysaccharide stimulates bovine neutrophil production of TNF-alpha, IL-1beta, IL-12 and IFN-gamma. Vet Res. 2007;38:809-18 pubmed
    ..the effects of LPS on the expression of cytokines secreted by bovine PMN, we measured the expression of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-12, and interferon (IFN)-gamma by ELISA after stimulation with ..
  6. Li X, Zhang R, Luo D, Park S, Wang Q, Kim Y, et al. Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation. J Biol Chem. 2005;280:15061-70 pubmed
    ..is pivotal component in cell apoptosis and can be activated by a variety of death stimuli including tumor necrosis factor (TNF) alpha and oxidative stress (reactive oxygen species)...
  7. Okuda K, Sakumoto R, Okamoto N, Acosta T, Abe H, Okada H, et al. Cellular localization of genes and proteins for tumor necrosis factor-α (TNF), TNF receptor types I and II in bovine endometrium. Mol Cell Endocrinol. 2010;330:41-8 pubmed publisher
    To determine which cell types produce tumor necrosis factor-α (TNF) and its receptors (TNFRI and TNFRII) in bovine endometrium, we investigated the expression and cellular localization of their mRNAs and proteins...
  8. Oviedo Boyso J, Cardoso Correa B, Cajero Juárez M, Bravo Patiño A, Valdez Alarcón J, Baizabal Aguirre V. The capacity of bovine endothelial cells to eliminate intracellular Staphylococcus aureus and Staphylococcus epidermidis is increased by the proinflammatory cytokines TNF-alpha and IL-1beta. FEMS Immunol Med Microbiol. 2008;54:53-9 pubmed publisher
    ..aureus is associated with the activation of NF-kappaB and modulated by the proinflammatory cytokines TNF-alpha and IL-1beta. In this work, we explore the ability of BEC to eliminate intracellular S. aureus and S...
  9. Woclawek Potocka I, Kowalczyk Zieba I, Tylingo M, Boruszewska D, Sinderewicz E, Skarzynski D. Effects of lysophopatidic acid on tumor necrosis factor α and interferon γ action in the bovine corpus luteum. Mol Cell Endocrinol. 2013;377:103-11 pubmed publisher
    We examined the effects of LPA on TNFα and IFNγ - induced decrease of P4 synthesis and on the cytokine - induced apoptosis of the cultured luteal cells...
  10. Sakumoto R, Hayashi K, Takahashi T. Different expression of PGE synthase, PGF receptor, TNF, Fas and oxytocin in the bovine corpus luteum of the estrous cycle and pregnancy. Reprod Biol. 2014;14:115-21 pubmed publisher
    ..Messenger RNA and protein levels of prostaglandin (PG) E synthase (PGES), PGF2α receptor (PGFR), tumor necrosis factor-α (TNF) and Fas were found to be higher in the CL of pregnancy than in CL of the cycle...

Detail Information

Publications54

  1. Konnai S, Usui T, Ikeda M, Kohara J, Hirata T, Okada K, et al. Tumor necrosis factor-alpha genetic polymorphism may contribute to progression of bovine leukemia virus-infection. Microbes Infect. 2006;8:2163-71 pubmed
    In a previous report, we had indicated that in a sheep model, the expression of tumor necrosis factor (TNF)-alpha was closely associated with disease progression in sheep experimentally infected with bovine leukemia virus (BLV)...
  2. Sadri H, Bruckmaier R, Rahmani H, Ghorbani G, Morel I, van Dorland H. Gene expression of tumour necrosis factor and insulin signalling-related factors in subcutaneous adipose tissue during the dry period and in early lactation in dairy cows. J Anim Physiol Anim Nutr (Berl). 2010;94:e194-202 pubmed publisher
    ..mRNA was quantified by real-time reverse transcription polymerase chain reaction for tumour necrosis factor alpha (TNFα), insulin-independent glucose transporter (GLUT1), insulin-responsive glucose transporter (GLUT4), insulin ..
  3. Hojo T, ODA A, Lee S, Acosta T, Okuda K. Effects of tumor necrosis factor α and Interferon γ on the viability and mRNA expression of TNF receptor type I in endothelial cells from the bovine corpus luteum. J Reprod Dev. 2010;56:515-9 pubmed
    ..We previously reported that a treatment combining tumor necrosis factor α (TNF) and interferon γ (IFNG) induced cell death in LSCs and that LECs express TNF receptor type I (..
  4. Anderson H, Rahmutula D, Gardner D. Tumor necrosis factor-alpha inhibits endothelial nitric-oxide synthase gene promoter activity in bovine aortic endothelial cells. J Biol Chem. 2004;279:963-9 pubmed
    b>Tumor necrosis factor-alpha (TNF-alpha) has been shown to reduce endothelial nitric-oxide synthase (eNOS) gene expression through post-transcriptional regulation of mRNA stability...
  5. Sohn E, Paape M, Connor E, Bannerman D, Fetterer R, Peters R. Bacterial lipopolysaccharide stimulates bovine neutrophil production of TNF-alpha, IL-1beta, IL-12 and IFN-gamma. Vet Res. 2007;38:809-18 pubmed
    ..the effects of LPS on the expression of cytokines secreted by bovine PMN, we measured the expression of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-12, and interferon (IFN)-gamma by ELISA after stimulation with ..
  6. Li X, Zhang R, Luo D, Park S, Wang Q, Kim Y, et al. Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation. J Biol Chem. 2005;280:15061-70 pubmed
    ..is pivotal component in cell apoptosis and can be activated by a variety of death stimuli including tumor necrosis factor (TNF) alpha and oxidative stress (reactive oxygen species)...
  7. Okuda K, Sakumoto R, Okamoto N, Acosta T, Abe H, Okada H, et al. Cellular localization of genes and proteins for tumor necrosis factor-α (TNF), TNF receptor types I and II in bovine endometrium. Mol Cell Endocrinol. 2010;330:41-8 pubmed publisher
    To determine which cell types produce tumor necrosis factor-α (TNF) and its receptors (TNFRI and TNFRII) in bovine endometrium, we investigated the expression and cellular localization of their mRNAs and proteins...
  8. Oviedo Boyso J, Cardoso Correa B, Cajero Juárez M, Bravo Patiño A, Valdez Alarcón J, Baizabal Aguirre V. The capacity of bovine endothelial cells to eliminate intracellular Staphylococcus aureus and Staphylococcus epidermidis is increased by the proinflammatory cytokines TNF-alpha and IL-1beta. FEMS Immunol Med Microbiol. 2008;54:53-9 pubmed publisher
    ..aureus is associated with the activation of NF-kappaB and modulated by the proinflammatory cytokines TNF-alpha and IL-1beta. In this work, we explore the ability of BEC to eliminate intracellular S. aureus and S...
  9. Woclawek Potocka I, Kowalczyk Zieba I, Tylingo M, Boruszewska D, Sinderewicz E, Skarzynski D. Effects of lysophopatidic acid on tumor necrosis factor α and interferon γ action in the bovine corpus luteum. Mol Cell Endocrinol. 2013;377:103-11 pubmed publisher
    We examined the effects of LPA on TNFα and IFNγ - induced decrease of P4 synthesis and on the cytokine - induced apoptosis of the cultured luteal cells...
  10. Sakumoto R, Hayashi K, Takahashi T. Different expression of PGE synthase, PGF receptor, TNF, Fas and oxytocin in the bovine corpus luteum of the estrous cycle and pregnancy. Reprod Biol. 2014;14:115-21 pubmed publisher
    ..Messenger RNA and protein levels of prostaglandin (PG) E synthase (PGES), PGF2α receptor (PGFR), tumor necrosis factor-α (TNF) and Fas were found to be higher in the CL of pregnancy than in CL of the cycle...
  11. Cludts I, Cleuter Y, Kettmann R, Burny A, Droogmans L. Cloning and characterization of the tandemly arranged bovine lymphotoxin and tumour necrosis factor-alpha genes. Cytokine. 1993;5:336-41 pubmed
    The screening of a bovine genomic library with a human tumour necrosis factor-alpha (TNF-alpha) cDNA probe resulted in the isolation of a 7.2 kb DNA fragment containing the entire bovine TNF-alpha gene...
  12. Itoh S, Lemay S, Osawa M, Che W, Duan Y, Tompkins A, et al. Mitochondrial Dok-4 recruits Src kinase and regulates NF-kappaB activation in endothelial cells. J Biol Chem. 2005;280:26383-96 pubmed
    ..Dok-4-WT enhanced tumor necrosis factor-alpha (TNF-alpha)-mediated reactive oxygen species (ROS) production, supporting the functional relevance ..
  13. Xu G, Li Y, Yang J, Zhou X, Yin X, Liu M, et al. Effect of recombinant Mce4A protein of Mycobacterium bovis on expression of TNF-alpha, iNOS, IL-6, and IL-12 in bovine alveolar macrophages. Mol Cell Biochem. 2007;302:1-7 pubmed
    ..such as MtbPPD, MbPPD, and BCG), followed by real-time RT-PCR assay for the mRNA expression level of TNF-alpha, iNOS, IL-6, and IL-12...
  14. Samavati L, Lee I, Mathes I, Lottspeich F, Huttemann M. Tumor necrosis factor alpha inhibits oxidative phosphorylation through tyrosine phosphorylation at subunit I of cytochrome c oxidase. J Biol Chem. 2008;283:21134-44 pubmed publisher
    ..The pro-inflammatory cytokine tumor necrosis factor alpha (TNFalpha) has been shown to play a central role in inflammation...
  15. Zhang H, Zhang R, Luo Y, D Alessio A, Pober J, Min W. AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation. J Biol Chem. 2004;279:44955-65 pubmed
    ..that ASK-interacting protein 1 (AIP1, also known as DAB2IP), a novel member of the Ras-GAP protein family, mediates TNF-induced activation of ASK1-JNK signaling pathway...
  16. Chou W, Yu T, Chen S, Peh H, Liu W, Chen M, et al. TNFalpha-mediated plasminogen activation on neutrophils is involved in the high plasmin activity in mammary secretion of drying-off cows. J Dairy Res. 2009;76:459-68 pubmed publisher
    ..The purposes of the present study were to examine the role of TNF-alpha in polymorphonuclear neutrophil (PMN)-associated Pg activation, and the significance of this activation ..
  17. Konnai S, Usui T, Ikeda M, Kohara J, Hirata T, Okada K, et al. Tumor necrosis factor-alpha up-regulation in spontaneously proliferating cells derived from bovine leukemia virus-infected cattle. Arch Virol. 2006;151:347-60 pubmed
    We previously reported that tumor necrosis factor alpha (TNF-alpha) was one of the cytokines that contributed to the leukemogenesis caused by bovine leukemia virus (BLV)...
  18. Purmessur D, Walter B, Roughley P, Laudier D, Hecht A, Iatridis J. A role for TNFα in intervertebral disc degeneration: a non-recoverable catabolic shift. Biochem Biophys Res Commun. 2013;433:151-6 pubmed publisher
    This study examines the effect of TNFα on whole bovine intervertebral discs in organ culture and its association with changes characteristic of intervertebral disc degeneration (IDD) in order to inform future treatments to mitigate the ..
  19. Yang W, Zerbe H, Petzl W, Brunner R, Günther J, Draing C, et al. Bovine TLR2 and TLR4 properly transduce signals from Staphylococcus aureus and E. coli, but S. aureus fails to both activate NF-kappaB in mammary epithelial cells and to quickly induce TNFalpha and interleukin-8 (CXCL8) expression in the udder. Mol Immunol. 2008;45:1385-97 pubmed
    ..Rather, the pathogen causing subclinical mastitis impairs NF-kappaB activation in MEC thereby severely weakening the immune response in the udder. ..
  20. Tamura R, Nemoto T, Maruta T, Onizuka S, Yanagita T, Wada A, et al. Up-regulation of NaV1.7 sodium channels expression by tumor necrosis factor-α in cultured bovine adrenal chromaffin cells and rat dorsal root ganglion neurons. Anesth Analg. 2014;118:318-24 pubmed publisher
    b>Tumor necrosis factor-α (TNF-α) is not only a key regulator of inflammatory response but also an important pain modulator...
  21. Zhang W, Zheng S, Storz P, Min W. Protein kinase D specifically mediates apoptosis signal-regulating kinase 1-JNK signaling induced by H2O2 but not tumor necrosis factor. J Biol Chem. 2005;280:19036-44 pubmed
    Although both tumor necrosis factor (TNF) and H2O2 induce activation of c-Jun N-terminal kinase (JNK) kinase cascades, it is not known whether they utilize distinct intracellular signaling pathways...
  22. Sui Y, Lee J, DiMicco M, Vanderploeg E, Blake S, Hung H, et al. Mechanical injury potentiates proteoglycan catabolism induced by interleukin-6 with soluble interleukin-6 receptor and tumor necrosis factor alpha in immature bovine and adult human articular cartilage. Arthritis Rheum. 2009;60:2985-96 pubmed publisher
    ..The present study was undertaken to study the combined effects of compression injury, tumor necrosis factor alpha (TNFalpha), and interleukin-6 (IL-6) and its soluble receptor (sIL-6R) on immature bovine and adult ..
  23. Ono H, Ichiki T, Ohtsubo H, Fukuyama K, Imayama I, Iino N, et al. CAMP-response element-binding protein mediates tumor necrosis factor-alpha-induced vascular cell adhesion molecule-1 expression in endothelial cells. Hypertens Res. 2006;29:39-47 pubmed
    ..b>Tumor necrosis factor-alpha (TNFalpha) induces endothelial dysfunction and VCAM-1 expression in endothelial cells (ECs)...
  24. Yuan K, Farney J, Mamedova L, Sordillo L, Bradford B. TNFα altered inflammatory responses, impaired health and productivity, but did not affect glucose or lipid metabolism in early-lactation dairy cows. PLoS ONE. 2013;8:e80316 pubmed publisher
    ..We tested whether administering an inflammatory cytokine, recombinant bovine tumor necrosis factor-α (rbTNFα), affects milk production, metabolism, and health during this period...
  25. Gilbert S, Duance V, Mason D. Tumour necrosis factor alpha up-regulates protein kinase R (PKR)-activating protein (PACT) and increases phosphorylation of PKR and eukaryotic initiation factor 2-alpha in articular chondrocytes. Biochem Soc Trans. 2002;30:886-9 pubmed
    ....
  26. Goodwin B, Pendleton L, Levy M, Solomonson L, Eichler D. Tumor necrosis factor-alpha reduces argininosuccinate synthase expression and nitric oxide production in aortic endothelial cells. Am J Physiol Heart Circ Physiol. 2007;293:H1115-21 pubmed
    Endothelial dysfunction associated with elevated serum levels of TNF-alpha observed in diabetes, obesity, and congenital heart disease results, in part, from the impaired production of endothelial nitric oxide (NO)...
  27. Woclawek Potocka I, Deptula K, Bah M, Lee H, Okuda K, Skarzynski D. Effects of nitric oxide and tumor necrosis factor-alpha on production of prostaglandin F2alpha and E2 in bovine endometrial cells. J Reprod Dev. 2004;50:333-40 pubmed
    The purpose of this study was to determine whether nitric oxide (NO) mediates tumor necrosis factor (TNF)alpha influence on the bovine endometrium. TNFalpha influence on the bovine endometrium is limited to the stromal cells...
  28. Sakumoto R, Shibaya M, Okuda K. Tumor necrosis factor-alpha (TNF alpha) inhibits progesterone and estradiol-17beta production from cultured granulosa cells: presence of TNFalpha receptors in bovine granulosa and theca cells. J Reprod Dev. 2003;49:441-9 pubmed
    The aim of this study was to investigate whether functional tumor necrosis factor-alpha (TNFalpha) receptors are present in the granulosa cells and the cells of theca interna (theca cells), obtained from bovine follicles classified into ..
  29. Moyes K, Drackley J, Morin D, Loor J. Greater expression of TLR2, TLR4, and IL6 due to negative energy balance is associated with lower expression of HLA-DRA and HLA-A in bovine blood neutrophils after intramammary mastitis challenge with Streptococcus uberis. Funct Integr Genomics. 2010;10:53-61 pubmed publisher
    ..ALOX5AP, CPNE3, IL1R2, IL6, TLR2, TLR4, and THY1, and downregulated genes were HLA-DRA, HLA-A, IRAK1, SOD1, and TNF. Network analysis revealed that TNF was associated with several of the affected genes in NEB cows compared with PEB ..