TNF

Summary

Gene Symbol: TNF
Description: tumor necrosis factor
Alias: TNF-a, TNF-alpha, TNFa, tumor necrosis factor, cachectin, tumor necrosis factor alpha, tumor necrosis factor ligand superfamily member 2
Species: cow

Top Publications

  1. ncbi Rapid communication: single strand conformational polymorphism (SSCP) of bovine tumor necrosis factor alpha
    A B Dietz
    USDA, ARS, Metabolic Diseases and Immunology Research Unit, National Animal Disease Center, Ames, IA 50010, USA
    J Anim Sci 75:2567. 1997
  2. ncbi Tumor necrosis factor-alpha genetic polymorphism may contribute to progression of bovine leukemia virus-infection
    Satoru Konnai
    Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060 0818, Japan
    Microbes Infect 8:2163-71. 2006
  3. doi Effects of tumor necrosis factor-alpha and nitric oxide on prostaglandins secretion by the bovine oviduct differ in the isthmus and ampulla and depend on the phase of the estrous cycle
    Marta J Siemieniuch
    Department of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, 10 747 Olsztyn, Poland
    Exp Biol Med (Maywood) 234:1056-66. 2009
  4. pmc Tumor necrosis factor alpha-dependent aggrecan cleavage and release of glycosaminoglycans in the meniscus is mediated by nitrous oxide-independent aggrecanase activity in vitro
    Henning Voigt
    Institute of Anatomy, Christian Albrechts University Kiel, Olshausenstr 40, Kiel, 24098, Germany
    Arthritis Res Ther 11:R141. 2009
  5. doi Daily injection of tumor necrosis factor-{alpha} increases hepatic triglycerides and alters transcript abundance of metabolic genes in lactating dairy cattle
    Barry J Bradford
    Department of Animal Sciences and Industry, Kansas State University, Manhattan, KS 66506, USA
    J Nutr 139:1451-6. 2009
  6. ncbi Metabolic and lactational responses during recombinant bovine tumor necrosis factor-alpha treatment in lactating cows
    S Kushibiki
    Department of Animal Production, National Agricultural Research Organization, National Agricultural Research Center for Tohoku Region, Iwate ken 020 0198, Japan
    J Dairy Sci 86:819-27. 2003
  7. ncbi Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation
    Xianghong Li
    Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine, Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 280:15061-70. 2005
  8. pmc TNFα altered inflammatory responses, impaired health and productivity, but did not affect glucose or lipid metabolism in early-lactation dairy cows
    Kai Yuan
    Department of Animal Sciences and Industry, Kansas State University, Manhattan, Kansas, United States of America
    PLoS ONE 8:e80316. 2013
  9. doi Effects of lysophopatidic acid on tumor necrosis factor α and interferon γ action in the bovine corpus luteum
    Izabela Woclawek-Potocka
    Department of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, 10 747 Olsztyn, Poland
    Mol Cell Endocrinol 377:103-11. 2013
  10. ncbi Changes occurring in immune responsiveness of single- and twin-bearing Comisana ewes during the transition period
    M Caroprese
    Dipartimento PRIME, Universita di Foggia, Via Napoli 25, 71100 Foggia, Italy
    J Dairy Sci 89:562-8. 2006

Scientific Experts

  • Satoru Konnai
  • R Sakumoto
  • Barry J Bradford
  • Izabela Woclawek-Potocka
  • Katarzyna Wojdak-Maksymiec
  • B Bojarojć-Nosowicz
  • Kiyoshi Okuda
  • Shiro Kushibiki
  • Ted H Elsasser
  • S J Gilbert
  • Lobelia Samavati
  • S Kahl
  • Henning Voigt
  • A Peli
  • Javier Oviedo-Boyso
  • Takuo Hojo
  • Pamela Anahi Lendez
  • Sanjeev Ranjan
  • E Correia-Álvarez
  • Hironori Abe
  • Angela Lau
  • Ryuji Tamura
  • Yurie Kawasaki
  • Kai Yuan
  • T Janowski
  • D Purmessur
  • K Lukasik
  • Wang Min
  • A Z Szóstek
  • Soumitra Roy
  • H Sadri
  • Kasey M Moyes
  • Yihong Sui
  • Marta J Siemieniuch
  • Wen K Chou
  • Alejandro Bravo-Patiño
  • Victor M Baizabal-Aguirre
  • Marcos Cajero-Juárez
  • Juan J Valdez-Alarcón
  • Wei Yang
  • Eun J Sohn
  • Guangxian Xu
  • Bonnie L Goodwin
  • M Caroprese
  • Hiroki Ono
  • Seigo Itoh
  • Wei Zhang
  • Xianghong Li
  • Rong Zhang
  • Hope D I Anderson
  • Haifeng Zhang
  • Deepak Sharma
  • S Perez
  • Juan Antonio Passucci
  • E Gomez
  • Amit Kumar
  • M Munoz
  • J N Caamano
  • Silvina Elena Gutierrez
  • A Balseiro
  • Rajib Deb
  • D Martin
  • Guillermina Laura Dolcini
  • N Peynot
  • C Giraud-Delville
  • Manjit Panigrahi
  • Pushpendra Kumar
  • V Duranthon
  • Maria Carolina Ceriani
  • O Sandra
  • Mario Andres Poli
  • Bharat Bhushan
  • S Carrocera
  • Ellen M Greenblatt
  • Isao Tsuneyoshi
  • Akihiko Wada
  • Theodore J Brown
  • W Allan King
  • Shin Onizuka
  • Carl Virtanen
  • Takashi Shimizu
  • Takayuki Nemoto
  • Chiho Kawashima
  • Alicia A Tone
  • Alexandra Kollara
  • Fumie Magata
  • Koumei Shirasuna
  • Akio Miyamoto
  • Yuka Aoki
  • Toshihiko Yanagita

Detail Information

Publications54

  1. ncbi Rapid communication: single strand conformational polymorphism (SSCP) of bovine tumor necrosis factor alpha
    A B Dietz
    USDA, ARS, Metabolic Diseases and Immunology Research Unit, National Animal Disease Center, Ames, IA 50010, USA
    J Anim Sci 75:2567. 1997
  2. ncbi Tumor necrosis factor-alpha genetic polymorphism may contribute to progression of bovine leukemia virus-infection
    Satoru Konnai
    Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060 0818, Japan
    Microbes Infect 8:2163-71. 2006
    In a previous report, we had indicated that in a sheep model, the expression of tumor necrosis factor (TNF)-alpha was closely associated with disease progression in sheep experimentally infected with bovine leukemia virus (BLV)...
  3. doi Effects of tumor necrosis factor-alpha and nitric oxide on prostaglandins secretion by the bovine oviduct differ in the isthmus and ampulla and depend on the phase of the estrous cycle
    Marta J Siemieniuch
    Department of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, 10 747 Olsztyn, Poland
    Exp Biol Med (Maywood) 234:1056-66. 2009
    To determine the possible roles of tumor necrosis factor-alpha (TNFalpha) and nitric oxide (NO) in the bovine oviduct, ampulla and isthmus collected during the estrous cycle were exposed for 18 h to TNFalpha, NO donor (NONOate), NO ..
  4. pmc Tumor necrosis factor alpha-dependent aggrecan cleavage and release of glycosaminoglycans in the meniscus is mediated by nitrous oxide-independent aggrecanase activity in vitro
    Henning Voigt
    Institute of Anatomy, Christian Albrechts University Kiel, Olshausenstr 40, Kiel, 24098, Germany
    Arthritis Res Ther 11:R141. 2009
    ..Since joint inflammation appears to be a causative factor for meniscal destruction, we investigated the influence of tumor necrosis factor (TNFalpha) on glycosaminoglycan (GAG) release and aggrecan cleavage in an in vitro model.
  5. doi Daily injection of tumor necrosis factor-{alpha} increases hepatic triglycerides and alters transcript abundance of metabolic genes in lactating dairy cattle
    Barry J Bradford
    Department of Animal Sciences and Industry, Kansas State University, Manhattan, KS 66506, USA
    J Nutr 139:1451-6. 2009
    To determine whether inflammation can induce bovine fatty liver, we administered recombinant bovine tumor necrosis factor-alpha (rbTNF) to late-lactation Holstein cows...
  6. ncbi Metabolic and lactational responses during recombinant bovine tumor necrosis factor-alpha treatment in lactating cows
    S Kushibiki
    Department of Animal Production, National Agricultural Research Organization, National Agricultural Research Center for Tohoku Region, Iwate ken 020 0198, Japan
    J Dairy Sci 86:819-27. 2003
    This study examined the effects of recombinant bovine tumor necrosis factor-alpha (rbTNF) administration on metabolic and hormonal responses and lactational performance in dairy cows...
  7. ncbi Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation
    Xianghong Li
    Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine, Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 280:15061-70. 2005
    ..is pivotal component in cell apoptosis and can be activated by a variety of death stimuli including tumor necrosis factor (TNF) alpha and oxidative stress (reactive oxygen species)...
  8. pmc TNFα altered inflammatory responses, impaired health and productivity, but did not affect glucose or lipid metabolism in early-lactation dairy cows
    Kai Yuan
    Department of Animal Sciences and Industry, Kansas State University, Manhattan, Kansas, United States of America
    PLoS ONE 8:e80316. 2013
    ..We tested whether administering an inflammatory cytokine, recombinant bovine tumor necrosis factor-α (rbTNFα), affects milk production, metabolism, and health during this period...
  9. doi Effects of lysophopatidic acid on tumor necrosis factor α and interferon γ action in the bovine corpus luteum
    Izabela Woclawek-Potocka
    Department of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, 10 747 Olsztyn, Poland
    Mol Cell Endocrinol 377:103-11. 2013
    We examined the effects of LPA on TNFα and IFNγ - induced decrease of P4 synthesis and on the cytokine - induced apoptosis of the cultured luteal cells...
  10. ncbi Changes occurring in immune responsiveness of single- and twin-bearing Comisana ewes during the transition period
    M Caroprese
    Dipartimento PRIME, Universita di Foggia, Via Napoli 25, 71100 Foggia, Italy
    J Dairy Sci 89:562-8. 2006
    ..In contrast, a relationship was found for the IgG secretions in milk and blood, which suggests that the assessment of humoral immune status may be combined with milking routine in dairy animals...
  11. doi Altered expression of inflammation-associated genes in oviductal cells following follicular fluid exposure: implications for ovarian carcinogenesis
    Angela Lau
    Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5T 3H7 Canada
    Exp Biol Med (Maywood) 239:24-32. 2014
    ..b>Tumor necrosis factor (TNF) and IL6 levels were also decreased while those of nicotinomide phosphoribosyltransferase (NAMPT) ..
  12. ncbi Protein kinase D specifically mediates apoptosis signal-regulating kinase 1-JNK signaling induced by H2O2 but not tumor necrosis factor
    Wei Zhang
    Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine, Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 280:19036-44. 2005
    Although both tumor necrosis factor (TNF) and H2O2 induce activation of c-Jun N-terminal kinase (JNK) kinase cascades, it is not known whether they utilize distinct intracellular signaling pathways...
  13. doi Up-regulation of NaV1.7 sodium channels expression by tumor necrosis factor-α in cultured bovine adrenal chromaffin cells and rat dorsal root ganglion neurons
    Ryuji Tamura
    From the Departments of Anesthesiology and Intensive Care and Pharmacology, Miyazaki Medical College, University of Miyazaki, Miyazaki, Japan Department of Anesthesiology, Division of Basic Research, Washington University School of Medicine, St Louis, Missouri Department of Sports Health and Welfare, Faculty of Social Welfare, Kyusyu University of Health and Welfare, Miyazaki, Japan
    Anesth Analg 118:318-24. 2014
    b>Tumor necrosis factor-α (TNF-α) is not only a key regulator of inflammatory response but also an important pain modulator...
  14. ncbi Prevalence of subclinical endometritis in repeat breeding cows and mRNA expression of tumor necrosis factor alpha and inducible nitric oxide synthase in the endometrium of repeat breeding cows with and without subclinical endometritis
    T Janowski
    Department of Animal Reproduction with Clinic, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 14, 10 719 Olsztyn, Poland
    Pol J Vet Sci 16:693-9. 2013
    ..a) to evaluate the incidence of this disorder with cytobrush cytology b) to analyze mRNA expression of tumor necrosis factor alpha (TNFalpha) and inducible nitric oxide synthase (iNOS) in endometrial biopsy samples collected from ..
  15. doi Different expression of PGE synthase, PGF receptor, TNF, Fas and oxytocin in the bovine corpus luteum of the estrous cycle and pregnancy
    R Sakumoto
    Animal Physiology Research Unit, National Institute of Agrobiological Sciences, Ibaraki 305 0901, Japan Electronic address
    Reprod Biol 14:115-21. 2014
    ..Messenger RNA and protein levels of prostaglandin (PG) E synthase (PGES), PGF2α receptor (PGFR), tumor necrosis factor-α (TNF) and Fas were found to be higher in the CL of pregnancy than in CL of the cycle...
  16. doi Association and expression analysis of single nucleotide polymorphisms of partial tumor necrosis factor alpha gene with mastitis in crossbred cattle
    Sanjeev Ranjan
    a Division of Animal Genetics, Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh, India
    Anim Biotechnol 26:98-104. 2015
    A total of 129 crossbred cows were selected to explore the genotypic and expression profiling of partial TNF-α gene and its association with mastitis susceptibility...
  17. doi Early embryonic and endometrial regulation of tumor necrosis factor and tumor necrosis factor receptor 2 in the cattle uterus
    E Correia-Álvarez
    Centro de Biotecnología Animal SERIDA, Gijon, Asturias, Spain
    Theriogenology 83:1028-37. 2015
    b>Tumor necrosis factor (TNF) alpha likely mediates embryomaternal communication in mammals...
  18. pmc The effect of single nucleotide polymorphisms in the tumor necrosis factor-α gene on reproductive performance and immune function in dairy cattle
    Yurie Kawasaki
    Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, 080 8555 Obihiro, Japan
    J Reprod Dev 60:173-8. 2014
    The present study aimed to assess the effect of polymorphisms in the tumor necrosis factor α (TNF-α) promoter (A/A, A/G and G/G) and exons (T/T, T/C and C/C) on immune function and reproductive performance in dairy cows...
  19. pmc Expression of matrix metalloproteinases in bovine luteal cells induced by prostaglandin F2α, interferon γ and tumor necrosis factor α
    Hironori Abe
    Laboratory of Reproductive Physiology, Graduate School of Environmental and Life Science, Okayama University, Okayama 700 8530, Japan
    J Reprod Dev 61:277-86. 2015
    ..by luteolytic factors, we investigated the effects of prostaglandin F2α (PGF), interferon γ (IFNG) and tumor necrosis factor α (TNF) on the mRNA expression of MMPs and TIMPs in cultured luteal cells...
  20. doi Association of TNF-α gene promoter region polymorphisms in bovine leukemia virus (BLV)-infected cattle with different proviral loads
    Pamela Anahi Lendez
    Area Virologia, Centro de Investigación Veterinaria de Tandil CIVETAN, CONICET, Facultad de Ciencias Veterinarias, UNCPBA, Campus Universitario, Arroyo Seco S N, 7000, Tandil, Argentina
    Arch Virol 160:2001-7. 2015
    b>Tumor necrosis factor alpha (TNF-α) is a pleiotropic cytokine involved in the immune response against viral and other infections. Its expression levels are affected by a polymorphism in the promoter region of the gene...
  21. pmc Parity-dependent association between TNF-α and LTF gene polymorphisms and clinical mastitis in dairy cattle
    Katarzyna Wojdak-Maksymiec
    Faculty of Biotechnology and Husbandry, Department of Animal Genetics and Breeding, West Pomeranian University of Technology in Szczecin, ul, Doktora Judyma 6, Szczecin, Poland
    BMC Vet Res 9:114. 2013
    ..We proposed tumor necrosis factor α (TNF-α), lactoferrin (LTF) and macrophage-expressed lysozyme (mLYZ) genes as potential DNA markers in ..
  22. pmc A role for TNFα in intervertebral disc degeneration: a non-recoverable catabolic shift
    D Purmessur
    Leni and Peter W May Department of Orthopaedics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
    Biochem Biophys Res Commun 433:151-6. 2013
    This study examines the effect of TNFα on whole bovine intervertebral discs in organ culture and its association with changes characteristic of intervertebral disc degeneration (IDD) in order to inform future treatments to mitigate the ..
  23. ncbi Polymorphism in the promoter region of the tumor necrosis factor-alpha gene in cattle herds naturally infected and uninfected with the bovine leukemia virus
    B Bojarojć-Nosowicz
    Department of Animal Genetics, University of Warmia and Mazury in Olsztyn Oczapowskiego 5, 10 719 Olsztyn, Poland
    Pol J Vet Sci 14:671-3. 2011
    The objective of this study was to describe and compare the genetic structure (TNF-alpha -position 824) of dairy cattle herds infected and not infected with the bovine leukemia virus (BLV)...
  24. doi Localization of gene and protein expressions of tumor necrosis factor-{alpha} and tumor necrosis factor receptor types I and II in the bovine corpus luteum during the estrous cycle
    R Sakumoto
    Reproductive Biology Research Unit, National Institute of Agrobiological Sciences, Ibaraki 305 0901, Japan
    J Anim Sci 89:3040-7. 2011
    One of the many roles of tumor necrosis factor (TNF)-α is to control mammalian corpus luteum (CL) PG synthesis and apoptotic cell death...
  25. doi Mechanical injury potentiates proteoglycan catabolism induced by interleukin-6 with soluble interleukin-6 receptor and tumor necrosis factor alpha in immature bovine and adult human articular cartilage
    Yihong Sui
    Massachusetts Institute of Technology, Cambridge, MA 01239, USA
    Arthritis Rheum 60:2985-96. 2009
    ..The present study was undertaken to study the combined effects of compression injury, tumor necrosis factor alpha (TNFalpha), and interleukin-6 (IL-6) and its soluble receptor (sIL-6R) on immature bovine and adult ..
  26. doi Greater expression of TLR2, TLR4, and IL6 due to negative energy balance is associated with lower expression of HLA-DRA and HLA-A in bovine blood neutrophils after intramammary mastitis challenge with Streptococcus uberis
    Kasey M Moyes
    Department of Animal Sciences, University of Illinois, Urbana, 61801, USA
    Funct Integr Genomics 10:53-61. 2010
    ..ALOX5AP, CPNE3, IL1R2, IL6, TLR2, TLR4, and THY1, and downregulated genes were HLA-DRA, HLA-A, IRAK1, SOD1, and TNF. Network analysis revealed that TNF was associated with several of the affected genes in NEB cows compared with PEB ..
  27. ncbi Effects of tumor necrosis factor α and Interferon γ on the viability and mRNA expression of TNF receptor type I in endothelial cells from the bovine corpus luteum
    Takuo Hojo
    Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University, Japan
    J Reprod Dev 56:515-9. 2010
    ..We previously reported that a treatment combining tumor necrosis factor α (TNF) and interferon γ (IFNG) induced cell death in LSCs and that LECs express TNF receptor type I (..
  28. doi Gene expression of tumour necrosis factor and insulin signalling-related factors in subcutaneous adipose tissue during the dry period and in early lactation in dairy cows
    H Sadri
    Veterinary Physiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland
    J Anim Physiol Anim Nutr (Berl) 94:e194-202. 2010
    ..mRNA was quantified by real-time reverse transcription polymerase chain reaction for tumour necrosis factor alpha (TNFα), insulin-independent glucose transporter (GLUT1), insulin-responsive glucose transporter (GLUT4), insulin ..
  29. doi Cellular localization of genes and proteins for tumor necrosis factor-α (TNF), TNF receptor types I and II in bovine endometrium
    K Okuda
    Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University, Okayama 700 8530, Japan
    Mol Cell Endocrinol 330:41-8. 2010
    To determine which cell types produce tumor necrosis factor-α (TNF) and its receptors (TNFRI and TNFRII) in bovine endometrium, we investigated the expression and cellular localization of their mRNAs and proteins...
  30. doi Tumor necrosis factor-α inhibits the stimulatory effect of luteinizing hormone and prostaglandin E(2) on progesterone secretion by the bovine corpus luteum
    A Z Szóstek
    Department of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research, Olsztyn, Poland
    Domest Anim Endocrinol 40:183-91. 2011
    b>Tumor necrosis factor-α (TNF-α) is involved in the tissue remodeling that occurs in the corpus luteum (CL) during its development and regression...
  31. doi Modeling the effects of estradiol and progesterone on the acute phase proinflammatory axis: variability in tumor necrosis factor-α, nitric oxide, and xanthine oxidase responses to endotoxin challenge in steers
    S Kahl
    Bovine Functional Genomics Laboratory, US Department of Agriculture, Agricultural Research Service, Animal and Natural Resources Institute, Beltsville, MD 20705, USA
    Domest Anim Endocrinol 40:213-21. 2011
    ..Plasma concentrations of the proinflammatory initiation cytokine tumor necrosis factor-α (TNF-α), nitrate+nitrite [NO(x), estimate of nitric oxide (NO) production], haptoglobin (HG; acute ..
  32. doi Role of TGF-β1 and TNF-α in IL-1β mediated activation of proMMP-9 in pulmonary artery smooth muscle cells: involvement of an aprotinin sensitive protease
    Soumitra Roy
    Department of Biochemistry and Biophysics, University of Kalyani, West Bengal, India
    Arch Biochem Biophys 513:61-9. 2011
    We investigated the role of TGF-β1 and TNF-α in mediating the effect of IL-1β in activating proMMP-9 and proMMP-2, and the involvement of an aprotinin sensitive protease in this scenario in bovine pulmonary artery smooth muscle cells...
  33. ncbi Tumor necrosis factor-alpha up-regulation in spontaneously proliferating cells derived from bovine leukemia virus-infected cattle
    S Konnai
    Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan
    Arch Virol 151:347-60. 2006
    We previously reported that tumor necrosis factor alpha (TNF-alpha) was one of the cytokines that contributed to the leukemogenesis caused by bovine leukemia virus (BLV)...
  34. ncbi Cloning and characterization of the tandemly arranged bovine lymphotoxin and tumour necrosis factor-alpha genes
    I Cludts
    Department of Molecular Biology, University of Brussels ULB, Belgium
    Cytokine 5:336-41. 1993
    The screening of a bovine genomic library with a human tumour necrosis factor-alpha (TNF-alpha) cDNA probe resulted in the isolation of a 7.2 kb DNA fragment containing the entire bovine TNF-alpha gene...
  35. ncbi Single nucleotide polymorphism (SNP) discovery and linkage mapping of bovine cytokine genes
    W M Grosse
    United States Department of Agriculture, Agricultural Research Service, Roman L Hruska U S Meat Animal Research Center MARC, P O Box 166, State Spur 18D, Clay Center, Nebraska 68933, USA
    Mamm Genome 10:1062-9. 1999
    ..Bovine loci for a cluster of IL8 receptors, a stromal cell-derived factor 1, interferon-gamma, and tumor necrosis factor-alpha were mapped at 90, 55, 59, and 34 cM, respectively, from the centromeric ends of the BTA 2, 28, 5, ..
  36. ncbi Tumour necrosis factor alpha up-regulates protein kinase R (PKR)-activating protein (PACT) and increases phosphorylation of PKR and eukaryotic initiation factor 2-alpha in articular chondrocytes
    S J Gilbert
    Connective Tissue Biology Laboratories, School of Biosciences, Cardiff University, Museum Avenue, Wales, UK
    Biochem Soc Trans 30:886-9. 2002
    ....
  37. ncbi Tumor necrosis factor-alpha inhibits endothelial nitric-oxide synthase gene promoter activity in bovine aortic endothelial cells
    Hope D I Anderson
    Diabetes Center and Department of Medicine, University of California at San Francisco, San Francisco, California 94143 0540, USA
    J Biol Chem 279:963-9. 2004
    b>Tumor necrosis factor-alpha (TNF-alpha) has been shown to reduce endothelial nitric-oxide synthase (eNOS) gene expression through post-transcriptional regulation of mRNA stability...
  38. ncbi Tumor necrosis factor-alpha (TNF alpha) inhibits progesterone and estradiol-17beta production from cultured granulosa cells: presence of TNFalpha receptors in bovine granulosa and theca cells
    Ryosuke Sakumoto
    Laboratory of Reproductive Endocrinology, Faculty of Agriculture, Okayama University, Japan
    J Reprod Dev 49:441-9. 2003
    The aim of this study was to investigate whether functional tumor necrosis factor-alpha (TNFalpha) receptors are present in the granulosa cells and the cells of theca interna (theca cells), obtained from bovine follicles classified into ..
  39. ncbi Effects of nitric oxide and tumor necrosis factor-alpha on production of prostaglandin F2alpha and E2 in bovine endometrial cells
    Izabela Woclawek-Potocka
    Department of Reproductive Immunology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland
    J Reprod Dev 50:333-40. 2004
    The purpose of this study was to determine whether nitric oxide (NO) mediates tumor necrosis factor (TNF)alpha influence on the bovine endometrium. TNFalpha influence on the bovine endometrium is limited to the stromal cells...
  40. ncbi AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation
    Haifeng Zhang
    Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine, Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 279:44955-65. 2004
    ..that ASK-interacting protein 1 (AIP1, also known as DAB2IP), a novel member of the Ras-GAP protein family, mediates TNF-induced activation of ASK1-JNK signaling pathway...
  41. ncbi Quantitation of the cytokines TNF-alpha, IL-8 and IL-10 in bovine milk using real-time TaqMan PCR
    A Peli
    Department of Veterinary Clinical Sciences, Internal Medicine Section, Faculty of Veterinary Medicine, University of Bologna, Ozzano Emilia, Italy
    Vet Res Commun 28:359-62. 2004
  42. ncbi Characterization of calves exhibiting a novel inheritable TNF-alpha hyperresponsiveness to endotoxin: associations with increased pathophysiological complications
    T H Elsasser
    Growth Biology Laboratory, US Department of Agriculture, Agricultural Research Service, B 200, Rm 201, B A R C east, Beltsville, MD 20705, USA
    J Appl Physiol (1985) 98:2045-55. 2005
    ..of calves, herein termed "hyperresponders" (HPR), was identified and defined by the patterns of plasma TNF-alpha concentrations that developed following two challenges with endotoxin (LPS, 0...
  43. ncbi Mitochondrial Dok-4 recruits Src kinase and regulates NF-kappaB activation in endothelial cells
    Seigo Itoh
    Center for Cardiovascular Research, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 280:26383-96. 2005
    ..Dok-4-WT enhanced tumor necrosis factor-alpha (TNF-alpha)-mediated reactive oxygen species (ROS) production, supporting the functional relevance ..
  44. ncbi CAMP-response element-binding protein mediates tumor necrosis factor-alpha-induced vascular cell adhesion molecule-1 expression in endothelial cells
    Hiroki Ono
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Hypertens Res 29:39-47. 2006
    ..b>Tumor necrosis factor-alpha (TNFalpha) induces endothelial dysfunction and VCAM-1 expression in endothelial cells (ECs)...
  45. ncbi Tumor necrosis factor-alpha reduces argininosuccinate synthase expression and nitric oxide production in aortic endothelial cells
    Bonnie L Goodwin
    Department of Molecular Medicine, University of South Florida College of Medicine, MDC Box 7, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
    Am J Physiol Heart Circ Physiol 293:H1115-21. 2007
    Endothelial dysfunction associated with elevated serum levels of TNF-alpha observed in diabetes, obesity, and congenital heart disease results, in part, from the impaired production of endothelial nitric oxide (NO)...
  46. ncbi Effect of recombinant Mce4A protein of Mycobacterium bovis on expression of TNF-alpha, iNOS, IL-6, and IL-12 in bovine alveolar macrophages
    Guangxian Xu
    National Animal TSE Laboratory, College of Veterinary Medicine, China Agricultural University, Haidian District Yuanmingyuan Xi Lu 2, Beijing, 100094, China
    Mol Cell Biochem 302:1-7. 2007
    ..such as MtbPPD, MbPPD, and BCG), followed by real-time RT-PCR assay for the mRNA expression level of TNF-alpha, iNOS, IL-6, and IL-12...
  47. ncbi Bacterial lipopolysaccharide stimulates bovine neutrophil production of TNF-alpha, IL-1beta, IL-12 and IFN-gamma
    Eun J Sohn
    Department of Animal and Avian Sciences, University of Maryland, College Park, MD 20742, USA
    Vet Res 38:809-18. 2007
    ..the effects of LPS on the expression of cytokines secreted by bovine PMN, we measured the expression of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-12, and interferon (IFN)-gamma by ELISA after stimulation with ..
  48. ncbi Bovine TLR2 and TLR4 properly transduce signals from Staphylococcus aureus and E. coli, but S. aureus fails to both activate NF-kappaB in mammary epithelial cells and to quickly induce TNFalpha and interleukin-8 (CXCL8) expression in the udder
    Wei Yang
    Research Institute for the Biology of Farm Animals FBN, Wilhelm Stahl Allee 2, 18196 Dummerstorf, Germany
    Mol Immunol 45:1385-97. 2008
    ..Rather, the pathogen causing subclinical mastitis impairs NF-kappaB activation in MEC thereby severely weakening the immune response in the udder...
  49. pmc Tumor necrosis factor alpha inhibits oxidative phosphorylation through tyrosine phosphorylation at subunit I of cytochrome c oxidase
    Lobelia Samavati
    Department of Medicine, Division of Pulmonary Critical Care and Sleep Medicine, Wayne State University School of Medicine, 3990 John R, Detroit, MI 48201, USA
    J Biol Chem 283:21134-44. 2008
    ..The pro-inflammatory cytokine tumor necrosis factor alpha (TNFalpha) has been shown to play a central role in inflammation...
  50. doi The capacity of bovine endothelial cells to eliminate intracellular Staphylococcus aureus and Staphylococcus epidermidis is increased by the proinflammatory cytokines TNF-alpha and IL-1beta
    Javier Oviedo-Boyso
    Centro Multidisciplinario de Estudios en Biotecnología, Facultad de Medicina Veterinaria y Zootecnia, Universidad Michoacana de San Nicolas de Hidalgo, Morelia, Michoacan, Mexico
    FEMS Immunol Med Microbiol 54:53-9. 2008
    ..aureus is associated with the activation of NF-kappaB and modulated by the proinflammatory cytokines TNF-alpha and IL-1beta. In this work, we explore the ability of BEC to eliminate intracellular S. aureus and S...
  51. doi TNF-alpha reduces the level of Staphylococcus epidermidis internalization by bovine endothelial cells
    Javier Oviedo-Boyso
    Centro Multidisciplinario de Estudios en Biotecnología, Facultad de Medicina Veterinaria y Zootecnia, Universidad Michoacana de San Nicolas de Hidalgo, Michoacan, Mexico
    FEMS Microbiol Lett 292:92-9. 2009
    ..plays an important role during inflammation and it is the target of proinflammatory cytokines such as tumor necrosis factor alpha (TNF-alpha)...
  52. ncbi Cloning of two members of the TNF-superfamily in cattle: CD40 ligand and tumor necrosis factor alpha
    B Mertens
    International Livestock Research Institute, P O Box 30709, Nairobi, Kenya
    Immunogenetics 42:430-1. 1995
  53. doi TNFalpha-mediated plasminogen activation on neutrophils is involved in the high plasmin activity in mammary secretion of drying-off cows
    Wen K Chou
    Department of Animal Science, National Chung Hsing University, Taichung 402, Taiwan ROC
    J Dairy Res 76:459-68. 2009
    ..The purposes of the present study were to examine the role of TNF-alpha in polymorphonuclear neutrophil (PMN)-associated Pg activation, and the significance of this activation ..