LEP

Summary

Gene Symbol: LEP
Description: leptin
Alias: leptin, obese, obesity factor, truncated leptin
Species: cow
Products:     LEP

Top Publications

  1. Lusk J. Association of single nucleotide polymorphisms in the leptin gene with body weight and backfat growth curve parameters for beef cattle. J Anim Sci. 2007;85:1865-72 pubmed
    Previous research has identified differences in carcass characteristics across SNP in the bovine leptin gene at slaughter, but before feedlot operators implement selection and sorting strategies, more information is needed to determine ..
  2. Trujillo A, Casal A, Peñagaricano F, Carriquiry M, Chilibroste P. Association of SNP of neuropeptide Y, leptin, and IGF-1 genes with residual feed intake in confinement and under grazing condition in Angus cattle. J Anim Sci. 2013;91:4235-44 pubmed publisher
    ..of Angus female calves: one carrying simultaneously putative favorable allelic variants (SNP) of neuropeptide Y, leptin, and IGF-1 genes (VAL group) and another devoid of such alleles (CON group)...
  3. Jennings J, Wertz Lutz A, Pritchard R, Weaver A, Keisler D, Bruns K. Circulating ghrelin and leptin concentrations and growth hormone secretagogue receptor abundance in liver, muscle, and adipose tissue of beef cattle exhibiting differences in composition of gain. J Anim Sci. 2011;89:3954-72 pubmed publisher
    ..Beef steers (n = 72) were used to test the hypothesis that plasma ghrelin and leptin concentrations and abundance of the GHS-R in liver, muscle, and adipose tissues differ in steers exhibiting ..
  4. Foote A, Hales K, Kuehn L, Keisler D, King D, Shackelford S, et al. Relationship of leptin concentrations with feed intake, growth, and efficiency in finishing beef steers. J Anim Sci. 2015;93:4401-7 pubmed publisher
    The objective of this experiment was to determine the association of serum leptin concentrations with production measures including DMI, ADG, and G:F as well as carcass characteristics in genetically diverse finishing beef steers...
  5. Liefers S, Veerkamp R, te Pas M, Delavaud C, Chilliard Y, van der Lende T. Leptin concentrations in relation to energy balance, milk yield, intake, live weight, and estrus in dairy cows. J Dairy Sci. 2003;86:799-807 pubmed
    The objective of this study was to describe fluctuations in leptin concentrations during late pregnancy and lactation and to investigate how those fluctuations are related to energy balance, milk yield, milk components, dry matter intake, ..
  6. Soliman M, Kimura K, Ahmed M, Yamaji D, Matsushita Y, Okamatsu Ogura Y, et al. Inverse regulation of leptin mRNA expression by short- and long-chain fatty acids in cultured bovine adipocytes. Domest Anim Endocrinol. 2007;33:400-9 pubmed
    b>Leptin is an adipose tissue-derived cytokine plays key roles in the regulation of food intake and energy expenditure...
  7. Zieba D, Amstalden M, Morton S, Maciel M, Keisler D, Williams G. Regulatory roles of leptin at the hypothalamic-hypophyseal axis before and after sexual maturation in cattle. Biol Reprod. 2004;71:804-12 pubmed
    Studies assessed, either directly or indirectly, the role of GnRH in leptin-mediated stimulation of LH release in cattle before and after sexual maturation...
  8. Sarkar M, Schilffarth S, Schams D, Meyer H, Berisha B. The expression of leptin and its receptor during different physiological stages in the bovine ovary. Mol Reprod Dev. 2010;77:174-81 pubmed publisher
    b>Leptin, the hormonal product of the obese (ob) gene, circulates in the blood at levels paralleling those of fat reserves and regulates satiety...
  9. Feuermann Y, Mabjeesh S, Niv Spector L, Levin D, Shamay A. Prolactin affects leptin action in the bovine mammary gland via the mammary fat pad. J Endocrinol. 2006;191:407-13 pubmed
    ..Metabolic hormones, such as GH, glucocorticoids, insulin, and leptin are responsible for coordinating the body's response to metabolic homeostasis...
  10. Domínguez Mancera B, Barrientos Morales M, Cervantes Acosta P, Hernández Beltran A, Rodríguez Andrade A, González Ramírez R, et al. Leptin regulation of inward membrane currents, electrical activity and LH release in isolated bovine gonadotropes. Biochem Biophys Res Commun. 2017;491:53-58 pubmed publisher
    b>Leptin, a peptide hormone produced by adipocytes, is recognized as one of the signals involved in the onset of reproductive activity...

Detail Information

Publications66

  1. Lusk J. Association of single nucleotide polymorphisms in the leptin gene with body weight and backfat growth curve parameters for beef cattle. J Anim Sci. 2007;85:1865-72 pubmed
    Previous research has identified differences in carcass characteristics across SNP in the bovine leptin gene at slaughter, but before feedlot operators implement selection and sorting strategies, more information is needed to determine ..
  2. Trujillo A, Casal A, Peñagaricano F, Carriquiry M, Chilibroste P. Association of SNP of neuropeptide Y, leptin, and IGF-1 genes with residual feed intake in confinement and under grazing condition in Angus cattle. J Anim Sci. 2013;91:4235-44 pubmed publisher
    ..of Angus female calves: one carrying simultaneously putative favorable allelic variants (SNP) of neuropeptide Y, leptin, and IGF-1 genes (VAL group) and another devoid of such alleles (CON group)...
  3. Jennings J, Wertz Lutz A, Pritchard R, Weaver A, Keisler D, Bruns K. Circulating ghrelin and leptin concentrations and growth hormone secretagogue receptor abundance in liver, muscle, and adipose tissue of beef cattle exhibiting differences in composition of gain. J Anim Sci. 2011;89:3954-72 pubmed publisher
    ..Beef steers (n = 72) were used to test the hypothesis that plasma ghrelin and leptin concentrations and abundance of the GHS-R in liver, muscle, and adipose tissues differ in steers exhibiting ..
  4. Foote A, Hales K, Kuehn L, Keisler D, King D, Shackelford S, et al. Relationship of leptin concentrations with feed intake, growth, and efficiency in finishing beef steers. J Anim Sci. 2015;93:4401-7 pubmed publisher
    The objective of this experiment was to determine the association of serum leptin concentrations with production measures including DMI, ADG, and G:F as well as carcass characteristics in genetically diverse finishing beef steers...
  5. Liefers S, Veerkamp R, te Pas M, Delavaud C, Chilliard Y, van der Lende T. Leptin concentrations in relation to energy balance, milk yield, intake, live weight, and estrus in dairy cows. J Dairy Sci. 2003;86:799-807 pubmed
    The objective of this study was to describe fluctuations in leptin concentrations during late pregnancy and lactation and to investigate how those fluctuations are related to energy balance, milk yield, milk components, dry matter intake, ..
  6. Soliman M, Kimura K, Ahmed M, Yamaji D, Matsushita Y, Okamatsu Ogura Y, et al. Inverse regulation of leptin mRNA expression by short- and long-chain fatty acids in cultured bovine adipocytes. Domest Anim Endocrinol. 2007;33:400-9 pubmed
    b>Leptin is an adipose tissue-derived cytokine plays key roles in the regulation of food intake and energy expenditure...
  7. Zieba D, Amstalden M, Morton S, Maciel M, Keisler D, Williams G. Regulatory roles of leptin at the hypothalamic-hypophyseal axis before and after sexual maturation in cattle. Biol Reprod. 2004;71:804-12 pubmed
    Studies assessed, either directly or indirectly, the role of GnRH in leptin-mediated stimulation of LH release in cattle before and after sexual maturation...
  8. Sarkar M, Schilffarth S, Schams D, Meyer H, Berisha B. The expression of leptin and its receptor during different physiological stages in the bovine ovary. Mol Reprod Dev. 2010;77:174-81 pubmed publisher
    b>Leptin, the hormonal product of the obese (ob) gene, circulates in the blood at levels paralleling those of fat reserves and regulates satiety...
  9. Feuermann Y, Mabjeesh S, Niv Spector L, Levin D, Shamay A. Prolactin affects leptin action in the bovine mammary gland via the mammary fat pad. J Endocrinol. 2006;191:407-13 pubmed
    ..Metabolic hormones, such as GH, glucocorticoids, insulin, and leptin are responsible for coordinating the body's response to metabolic homeostasis...
  10. Domínguez Mancera B, Barrientos Morales M, Cervantes Acosta P, Hernández Beltran A, Rodríguez Andrade A, González Ramírez R, et al. Leptin regulation of inward membrane currents, electrical activity and LH release in isolated bovine gonadotropes. Biochem Biophys Res Commun. 2017;491:53-58 pubmed publisher
    b>Leptin, a peptide hormone produced by adipocytes, is recognized as one of the signals involved in the onset of reproductive activity...
  11. Li M, Adamowicz T, Switonski M, Ammosov I, Ivanova Z, Kiselyova T, et al. Analysis of population differentiation in North Eurasian cattle (Bos taurus) using single nucleotide polymorphisms in three genes associated with production traits. Anim Genet. 2006;37:390-2 pubmed
    Single nucleotide polymorphisms (SNPs) in growth hormone 1 (GH1), insulin-like growth factor 1 (IGF1) and leptin (LEP), all candidates for production traits in cattle, were characterized in North Eurasian cattle breeds...
  12. Kononoff P, Defoor P, Engler M, Swingle R, James S, Deobald H, et al. Impact of a leptin single nucleotide polymorphism and zilpaterol hydrochloride on growth and carcass characteristics in finishing steers. J Anim Sci. 2013;91:5011-7 pubmed publisher
    A total of 4,178 steers (mean initial BW = 403.9 ± 16.04 kg) were used to test the interactive effects, if any, of leptin R25C genotypes (CC, CT, or TT) and zilpaterol hydrochloride (ZH) feeding duration on growth performance and carcass ..
  13. Niciura S, Ibelli A, Gouveia G, Gromboni J, Rocha M, de Souza M, et al. Polymorphism and parent-of-origin effects on gene expression of CAST, leptin and DGAT1 in cattle. Meat Sci. 2012;90:507-10 pubmed publisher
    ..CAST, related to meat tenderness, and DGAT1 and leptin, related to fat deposition, were evaluated. In bovine fetal tissues CAST was expressed twice as much (P < 0...
  14. Chebel R, Susca F, Santos J. Leptin genotype is associated with lactation performance and health of Holstein cows. J Dairy Sci. 2008;91:2893-900 pubmed publisher
    ..were to evaluate the associations among single nucleotide polymorphisms (SNP) in the R4C locus in exon 2 of the leptin gene and the lactational performance and health of Holstein cows...
  15. Kremenskoy M, Kremenska Y, Suzuki M, Imai K, Takahashi S, Hashizume K, et al. Epigenetic characterization of the CpG islands of bovine Leptin and POU5F1 genes in cloned bovine fetuses. J Reprod Dev. 2006;52:277-85 pubmed
    ..In this study, we investigated the methylation status of the CpG islands of the bovine Leptin and POU5F1 genes in fetal and placental tissues from fetuses produced by artificial insemination (AI) and nuclear ..
  16. Olbromski R, Siadkowska E, Zelazowska B, Zwierzchowski L. Allelic gene expression imbalance of bovine IGF2, LEP and CCL2 genes in liver, kidney and pituitary. Mol Biol Rep. 2013;40:1189-200 pubmed publisher
    ..Out of the studied group of genes 3 of them-LEP (leptin), IGF2 (insulin-like growth factor 2), CCL2 (chemokine C-C motif ligand 2) showed allelic expression imbalance.
  17. Maciel M, Zieba D, Amstalden M, Keisler D, Neves J, Williams G. Leptin prevents fasting-mediated reductions in pulsatile secretion of luteinizing hormone and enhances its gonadotropin-releasing hormone-mediated release in heifers. Biol Reprod. 2004;70:229-35 pubmed
    We tested the hypothesis that leptin could prevent fasting-mediated reductions in pulsatile secretion and modify GnRH-mediated release of LH in heifers approaching puberty. Thirteen crossbred, prepubertal heifers (13...
  18. Ogasawara H, Ohwada S, Nagai Y, Taketa Y, Matsuzaki M, Tanaka S, et al. Localization of leptin and leptin receptor in the bovine adenohypophysis. Domest Anim Endocrinol. 2008;35:8-15 pubmed publisher
    The present study was carried out to detail the cellular localization of leptin (Lep) and the leptin receptor (LepR) in the bovine adenohypophysis...
  19. Perucatti A, Di Meo G, Vallinoto M, Kierstein G, Schneider M, Incarnato D, et al. FISH-mapping of LEP and SLC26A2 genes in sheep, goat and cattle R-banded chromosomes: comparison between bovine, ovine and caprine chromosome 4 (BTA4/OAR4/CHI4) and human chromosome 7 (HSA7). Cytogenet Genome Res. 2006;115:7-9 pubmed
    ..and cattle (BTA) R-banded chromosome preparations, obtained from synchronized cell cultures, were used to FISH-map leptin (LEP) and solute carrier family 26 member 2 (SLC26A2) genes on single chromosome bands...
  20. da Silva R, Ferraz J, Meirelles F, Eler J, Balieiro J, Cucco D, et al. Association of single nucleotide polymorphisms in the bovine leptin and leptin receptor genes with growth and ultrasound carcass traits in Nellore cattle. Genet Mol Res. 2012;11:3721-8 pubmed publisher
    Given the important role of leptin in metabolism, we looked for a possible association of leptin and leptin receptor polymorphisms with carcass and growth traits in Nellore cattle...
  21. Nassiry M, Moussavi A, Alashawkany A, Ghovati S. Leptin gene polymorphism in Iranian native Golpayegani and Taleshi cows. Pak J Biol Sci. 2007;10:3738-41 pubmed
    The objective of the present investigation was to study genetic variations in the exon II of leptin gene in Iranian Golpayegani and Taleshi cows...
  22. Glantz M, Lindmark Månsson H, Stålhammar H, Paulsson M. Effect of polymorphisms in the leptin, leptin receptor and acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) genes and genetic polymorphism of milk proteins on bovine milk composition. J Dairy Res. 2012;79:110-8 pubmed publisher
    ..The aim of this study was to determine if polymorphisms in the leptin (LEP), leptin receptor (LEPR) and acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) genes as well as genetic ..
  23. Kovaljuk N, Satsuk V, Volchenko A, Machulskaja E. [LEP gene allelic polymorphism in a subpopulation of Ayrshire cattle]. Genetika. 2015;51:266-70 pubmed
    Genotyping of the leptin gene locus (LEP) (SNP: R25C, Y7F, and A80V) has been conducted in cows from two cattle droves (n = 106 and n = 34) and in bulls of Ayrshire cattle (n = 9) that are intensively used at present for artificial ..
  24. Xi Y, Yang Z, Wu F, Han Z, Wang G. Gene expression profiling of hormonal regulation related to the residual feed intake of Holstein cattle. Biochem Biophys Res Commun. 2015;465:19-25 pubmed publisher
    ..expression of genes associated with hormonal regulation differs in dairy cows, depending on their RFI coefficients, and that these differences may be related to the molecular regulation of the leptin-NPY and insulin signaling pathways.
  25. Sadri H, Mielenz M, Morel I, Bruckmaier R, van Dorland H. Plasma leptin and mRNA expression of lipogenesis and lipolysis-related factors in bovine adipose tissue around parturition. J Anim Physiol Anim Nutr (Berl). 2011;95:790-7 pubmed publisher
    The objective was to study changes in plasma leptin concentration parallel to changes in the gene expression of lipogenic- and lipolytic-related genes in adipose tissue of dairy cows around parturition...
  26. Lagonigro R, Wiener P, Pilla F, Woolliams J, Williams J. A new mutation in the coding region of the bovine leptin gene associated with feed intake. Anim Genet. 2003;34:371-4 pubmed
    An experimental cattle population was screened for polymorphisms in the leptin gene and five SNPs were found in the regions containing the coding sequences...
  27. Leury B, Baumgard L, Block S, Segoale N, Ehrhardt R, Rhoads R, et al. Effect of insulin and growth hormone on plasma leptin in periparturient dairy cows. Am J Physiol Regul Integr Comp Physiol. 2003;285:R1107-15 pubmed
    ..We previously showed that this energy deficit contributes to a decline in plasma leptin. This decline mirrors that of plasma insulin but is reciprocal to the profile of plasma growth hormone (GH), ..
  28. Trakovická A, Moravčíková N, Kasarda R. Genetic polymorphisms of leptin and leptin receptor genes in relation with production and reproduction traits in cattle. Acta Biochim Pol. 2013;60:783-7 pubmed
    b>Leptin and leptin receptor genes are considered as production traits markers in dairy or beef cattle...
  29. Chebel R, Santos J. Association between leptin single nucleotide polymorphism and reproductive performance of lactating Holstein cows. Anim Reprod Sci. 2011;127:126-34 pubmed publisher
    ..performance of Holstein cows, single nucleotide polymorphism (SNP) in the R4C locus of the Exon-2 region of the leptin gene and health disorders...
  30. Nkrumah J, Li C, Yu J, Hansen C, Keisler D, Moore S. Polymorphisms in the bovine leptin promoter associated with serum leptin concentration, growth, feed intake, feeding behavior, and measures of carcass merit. J Anim Sci. 2005;83:20-8 pubmed
    b>Leptin is the hormone product of the obese gene synthesized and secreted predominantly by white adipocytes...
  31. Pfister Genskow M, Hayes H, Eggen A, Bishop M. Chromosomal localization of the bovine obesity (OBS) gene. Mamm Genome. 1996;7:398-9 pubmed
  32. Kononoff P, Defoor P, Engler M, Swingle R, James S, Marquess F. Impact of a leptin single nucleotide polymorphism and ractopamine hydrochloride on growth and carcass characteristics in finishing steers. J Anim Sci. 2014;92:2702-7 pubmed publisher
    A total of 2,958 steers (mean initial BW = 549.6 ± 3.88 kg) were used to test for the interactive effects, of leptin R25C genotypes (CC, CT, or TT) and feeding of ractopamine hydrochloride (RH) on growth performance and carcass traits...
  33. Thomas M, Amstalden M, Hallford D, Silver G, Garcia M, Keisler D, et al. Dynamics of GHRH in third-ventricle cerebrospinal fluid of cattle: relationship with serum concentrations of GH and responses to appetite-regulating peptides. Domest Anim Endocrinol. 2009;37:196-205 pubmed publisher
    ..the peripheral circulation; and (2) assess the influence of acute administration of appetite-regulating peptides leptin (anti-orexigenic) and neuropeptide Y (NPY; orexigenic) on the release of GHRH...
  34. Nicklin L, Robinson R, Marsters P, Campbell B, Mann G, Hunter M. Leptin in the bovine corpus luteum: receptor expression and effects on progesterone production. Mol Reprod Dev. 2007;74:724-9 pubmed
    In cattle, leptin has been implicated in the control of ovarian function and has been shown to modulate steroid production by theca and granulosa cells in a number of species...
  35. Yonekura S, Senoo T, Kobayashi Y, Yonezawa T, Katoh K, Obara Y. Effects of acetate and butyrate on the expression of leptin and short-form leptin receptor in bovine and rat anterior pituitary cells. Gen Comp Endocrinol. 2003;133:165-72 pubmed
    The effects of acetate and butyrate on leptin and leptin receptor (OB-R) expression in bovine and rat anterior pituitary were examined...
  36. Kononoff P, Defoor P, Engler M, Swingle R, Gleghorn J, James S, et al. Impacts of a leptin SNP on growth performance and carcass characters in finishing steers studied over time. J Anim Sci. 2017;95:194-200 pubmed publisher
    ..Steers were weighed and ultrasound scanned at 60 and 1 d prior to harvest. Leptin genotype affected ( ? 0.011) 12th-rib fat and i.m...
  37. Brickell J, Pollott G, Clempson A, Otter N, Wathes D. Polymorphisms in the bovine leptin gene associated with perinatal mortality in Holstein-Friesian heifers. J Dairy Sci. 2010;93:340-7 pubmed publisher
    b>Leptin is an important regulator of fetal and placental growth...
  38. Ravelich S, Shelling A, Ramachandran A, Reddy S, Keelan J, Wells D, et al. Altered placental lactogen and leptin expression in placentomes from bovine nuclear transfer pregnancies. Biol Reprod. 2004;71:1862-9 pubmed
    ..Hormones such as placental lactogen (PL) and leptin are produced in the bovine placenta and play an important role in nutrient partitioning and regulation of ..
  39. Liefers S, te Pas M, Veerkamp R, Chilliard Y, Delavaud C, Gerritsen R, et al. Association of leptin gene polymorphisms with serum leptin concentration in dairy cows. Mamm Genome. 2003;14:657-63 pubmed
    b>Leptin is a hormone produced by adipocytes, and its expression is regulated by body fatness and energy balance...
  40. Woronuk G, Marquess F, James S, Palmer J, Berryere T, Deobald H, et al. Association of leptin genotypes with beef cattle characteristics. Anim Genet. 2012;43:608-10 pubmed publisher
    A single nucleotide polymorphism (C/T) in bovine leptin, resulting in an arginine to cysteine amino acid substitution (p.Arg25Cys), has previously been shown to have an impact on carcass characteristics...
  41. Banos G, Woolliams J, Woodward B, Forbes A, Coffey M. Impact of single nucleotide polymorphisms in leptin, leptin receptor, growth hormone receptor, and diacylglycerol acyltransferase (DGAT1) gene loci on milk production, feed, and body energy traits of UK dairy cows. J Dairy Sci. 2008;91:3190-200 pubmed publisher
    The impact of 9 single nucleotide polymorphisms (SNP) in the leptin (LEP), leptin receptor (LEPR), growth hormone receptor (GHR), and diacylglycerol acyltransferase (DGAT1) gene loci on daily milk production, feed intake, and feed ..
  42. Buchanan F, van Kessel A, Waldner C, Christensen D, Laarveld B, Schmutz S. Hot topic: an association between a leptin single nucleotide polymorphism and milk and protein yield. J Dairy Sci. 2003;86:3164-6 pubmed
    Allelic variation (C to T transition that results in an Arg25Cys) in the leptin gene has been associated with increased fat deposition in beef cattle. We report that this same genetic variant is also present in dairy breeds...
  43. Schenkel F, Miller S, Ye X, Moore S, Nkrumah J, Li C, et al. Association of single nucleotide polymorphisms in the leptin gene with carcass and meat quality traits of beef cattle. J Anim Sci. 2005;83:2009-20 pubmed
    ..The objective of this study was to evaluate the association of previously reported SNP in the bovine leptin gene with carcass and meat quality traits from a large sample of crossbred beef cattle...
  44. Konfortov B, Licence V, Miller J. Re-sequencing of DNA from a diverse panel of cattle reveals a high level of polymorphism in both intron and exon. Mamm Genome. 1999;10:1142-5 pubmed
    In order to assess the extent of DNA sequence variation in cattle, introns and exons from both the leptin and Amyloid Precursor Protein (APP) genes have been sequenced in a panel of DNAs derived from 22 diverse animals...
  45. Foote A, Tait R, Keisler D, Hales K, Freetly H. Leptin concentrations in finishing beef steers and heifers and their association with dry matter intake, average daily gain, feed efficiency, and body composition. Domest Anim Endocrinol. 2016;55:136-41 pubmed publisher
    The objective of this experiment was to determine the association of circulating plasma leptin concentrations with production and body composition measures of finishing beef steers and heifers and to determine if multiple sampling time ..
  46. Oikonomou G, Angelopoulou K, Arsenos G, Zygoyiannis D, Banos G. The effects of polymorphisms in the DGAT1, leptin and growth hormone receptor gene loci on body energy, blood metabolic and reproductive traits of Holstein cows. Anim Genet. 2009;40:10-7 pubmed publisher
    ..of this study was to examine the impact of polymorphisms in the acyl-CoA:diacylglycerol acyltransferase (DGAT1), leptin and growth hormone receptor genes on body energy (body condition score, total body energy content and cumulative ..
  47. Cardoso S, Queiroz L, Goulart V, Mourão G, Benedetti E, Goulart L. Productive performance of the dairy cattle Girolando breed mediated by the fat-related genes DGAT1 and LEP and their polymorphisms. Res Vet Sci. 2011;91:e107-12 pubmed publisher
    ..have been associated with milk production in bovines, such as the diacylglycerol O-acyltransferase 1 (DGAT1) and leptin (LEP); however, they have not been simultaneously investigated nor have been evaluated in the Brazilian Girolando ..
  48. Leone A, Spatola G, Cucco D, Tessitore V, Bonaventura G, Uzzo M. Immunohistochemical expression and distribution of orexin, orphanin and leptin in the major salivary glands of some mammals. Folia Histochem Cytobiol. 2012;50:504-12 pubmed publisher
    The aim of the study was to determine by immunochemistry the expression of leptin, orexin A and orphanin FQ in the major salivary glands (parotid, submandibular and sublingual) of rat, sheep and cow...
  49. Woliński J, Słupecka M, Romanowicz K. Leptin and ghrelin levels in colostrum, milk and blood plasma of sows and pig neonates during the first week of lactation. Anim Sci J. 2014;85:143-9 pubmed publisher
    Radioimmunology was used to determine leptin and ghrelin levels in sow colostrum and milk in relation to those in sow and neonatal pig blood plasma and to the body weight of piglets during the first week of lactation...
  50. Hernandez N, Martínez González J, Parra Bracamonte G, Sifuentes Rincón A, Lopez Villalobos N, Morris S, et al. Association of polymorphisms in growth hormone and leptin candidate genes with live weight traits of Brahman cattle. Genet Mol Res. 2016;15: pubmed publisher
    ..035) with an estimate substitution effect of 3.97 kg (P = 0.0210). In addition, a leptin SNP (LEPg.978) was significantly associated with aYW (P = 0.003) with an estimate substitution effect of 9...
  51. Kadokawa H, Blache D, Martin G. Plasma leptin concentrations correlate with luteinizing hormone secretion in early postpartum Holstein cows. J Dairy Sci. 2006;89:3020-7 pubmed
    ..status and to circulating profiles of free fatty acids (FFA), insulin, insulin-like growth factor-I (IGF-I), leptin, and growth hormone (GH)...
  52. Kulig H, Kmiec M. Association between leptin gene polymorphisms and growth traits in Limousin cattle. Genetika. 2009;45:838-41 pubmed
    A total of 129 Limousin calves were used to investigate how leptin gene polymorphisms affect growth traits, such as body weight, average daily gain, wither height, sacrum height and chest girth in beef cattle...
  53. Orrù L, Cifuni G, Piasentier E, Corazzin M, Bovolenta S, Moioli B. Association analyses of single nucleotide polymorphisms in the LEP and SCD1 genes on the fatty acid profile of muscle fat in Simmental bulls. Meat Sci. 2011;87:344-8 pubmed publisher
    The aim was to investigate the effect of the genetic polymorphisms of leptin (LEP) and stearoyl-CoA desaturase (SCD1) genes on the fatty acid (FA) composition of the muscle of 103 Simmental bulls...
  54. Komisarek J, Antkowiak I. The relationship between leptin gene polymorphisms and reproductive traits in Jersey cows. Pol J Vet Sci. 2007;10:193-7 pubmed
    The aim of the study was to analyse the relationship between three leptin gene polymorphisms, and indices of reproductive performance--age at first calving, days open, calving interval, number of inseminations per conception, and ..
  55. Dayi A, Bediz C, Musal B, Yilmaz O, Comlekci A, Celiloglu M, et al. Comparison of leptin levels in serum and follicular fluid during the oestrous cycle in cows. Acta Vet Hung. 2005;53:457-67 pubmed
    b>Leptin is mainly synthesised in white adipose tissue. Besides its effects on body weight and metabolic homeostasis, leptin also has effects on puberty, sexual maturation and reproduction...
  56. DeVuyst E, Bauer M, Cheng F, Mitchell J, Larson D. The impact of a leptin gene SNP on beef calf weaning weights. Anim Genet. 2008;39:284-6 pubmed publisher
    Prior research indicates that a SNP at position 305 of exon 2 in the leptin gene affects milk production in dairy cows. Dairy cows with at least one copy of the T allele have been shown to have higher milk production than CC cows...
  57. Taniguchi Y, Itoh T, Yamada T, Sasaki Y. Genomic structure and promoter analysis of the bovine leptin gene. IUBMB Life. 2002;53:131-5 pubmed
    The product of the leptin gene is a 16-kDa protein secreted by adipose tissue and regulates adiposity...
  58. Haegeman A, Van Zeveren A, Peelman L. New mutation in exon 2 of the bovine leptin gene. Anim Genet. 2000;31:79 pubmed
  59. Clempson A, Pollott G, Brickell J, Bourne N, Munce N, Wathes D. Evidence that leptin genotype is associated with fertility, growth, and milk production in Holstein cows. J Dairy Sci. 2011;94:3618-28 pubmed publisher
    This study investigated associations between single nucleotide polymorphisms (SNP) in the leptin, leptin receptor, and neuropeptide Y (NPY) genes with growth, milk production, and fertility traits...
  60. Passos D, Hepp D, Moraes J, Weimer T. Effect of polymorphisms linked to LEP gene on its expression on adipose tissues in beef cattle. J Anim Breed Genet. 2007;124:157-62 pubmed
    In cattle, genetic markers at the leptin (LEP) gene and at those linked to the gene have been described as affecting calving interval (markers LEPSau3AI and IDVGA51), or daily weight gain (BMS1074 and BM1500)...
  61. Yang D, Chen H, Wang X, Tian Z, Tang L, Zhang Z, et al. Association of polymorphisms of leptin gene with body weight and body sizes indexes in Chinese indigenous cattle. J Genet Genomics. 2007;34:400-5 pubmed
    PCR-SSCP was used to analyze the polymorphism of leptin gene in 539 samples of six cattle breeds, namely Nanyang (NY), Qinchuan (QC), Jiaxianred (JXR), Xizhen (XZ), Luxi (LX), and Holstein cow (HOL) breeds...
  62. Feuermann Y, Mabjeesh S, Shamay A. Leptin affects prolactin action on milk protein and fat synthesis in the bovine mammary gland. J Dairy Sci. 2004;87:2941-6 pubmed
    b>Leptin, a protein hormone produced and secreted predominantly by white adipose tissue, has a critical role in the regulation and coordination of energy metabolism...
  63. Cardoso R, Alves B, Prezotto L, Thorson J, Tedeschi L, Keisler D, et al. Reciprocal changes in leptin and NPY during nutritional acceleration of puberty in heifers. J Endocrinol. 2014;223:289-98 pubmed publisher
    ..in GnRH/LH release during nutritional acceleration of puberty is accompanied by reciprocal changes in circulating leptin and central release of neuropeptide Y (NPY). The heifers were weaned at 3.5 months of age and fed to gain either 0...
  64. Smith J, Sheffield L. Production and regulation of leptin in bovine mammary epithelial cells. Domest Anim Endocrinol. 2002;22:145-54 pubmed
    Previously, leptin has been found in human and rodent mammary tissue...
  65. Orrù L, Abeni F, Catillo G, Grandoni F, Crisà A, De Matteis G, et al. Leptin gene haplotypes are associated with change in immunological and hematological variables in dairy cow during the peripartum period. J Anim Sci. 2012;90:16-26 pubmed publisher
    In this study, the effect of polymorphisms in the leptin gene on the hematological variables in periparturient dairy cows was investigated. The hematological profile of 67 Holstein cows was assessed for 6 wk around calving...