CDR1

Summary

Gene Symbol: CDR1
Description: multidrug resistance protein CDR1 originally isolated by ability to functionally substitute for S. cerevisiae PDR5 (YOR153W) ABC transporter
Alias: multidrug resistance protein CDR1
Species: Candida albicans SC5314

Top Publications

  1. pmc Candida drug resistance protein 1, a major multidrug ATP binding cassette transporter of Candida albicans, translocates fluorescent phospholipids in a reconstituted system
    Sudhanshu Shukla
    Membrane Biology Laboratory, School of Life Sciences, and Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi 110067, India
    Biochemistry 46:12081-90. 2007
  2. doi Chimeras of Candida albicans Cdr1p and Cdr2p reveal features of pleiotropic drug resistance transporter structure and function
    Koichi Tanabe
    Department of Bioactive Molecules, National Institute of Infectious Diseases, Tokyo 162 8640, Japan
    Mol Microbiol 82:416-33. 2011
  3. pmc Ncb2 is involved in activated transcription of CDR1 in azole-resistant clinical isolates of Candida albicans
    Shipra Shukla
    Special Centre for Molecular Medicine and Membrane Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India
    Eukaryot Cell 10:1357-66. 2011
  4. pmc Divergent signature motifs of nucleotide binding domains of ABC multidrug transporter, CaCdr1p of pathogenic Candida albicans, are functionally asymmetric and noninterchangeable
    Antresh Kumar
    Membrane Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India
    Biochim Biophys Acta 1798:1757-66. 2010
  5. pmc Fluconazole transport into Candida albicans secretory vesicles by the membrane proteins Cdr1p, Cdr2p, and Mdr1p
    Luiz R Basso
    Division of Infectious Diseases, Department of Medicine, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, Portland, OR 97239, USA
    Eukaryot Cell 9:960-70. 2010
  6. pmc The amino acid residues of transmembrane helix 5 of multidrug resistance protein CaCdr1p of Candida albicans are involved in substrate specificity and drug transport
    Nidhi Puri
    Membrane Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India
    Biochim Biophys Acta 1788:1752-61. 2009
  7. doi A novel catalytic mechanism for ATP hydrolysis employed by the N-terminal nucleotide-binding domain of Cdr1p, a multidrug ABC transporter of Candida albicans
    Versha Rai
    Membrane Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India
    Biochim Biophys Acta 1778:2143-53. 2008
  8. pmc Conserved Asp327 of walker B motif in the N-terminal nucleotide binding domain (NBD-1) of Cdr1p of Candida albicans has acquired a new role in ATP hydrolysis
    Versha Rai
    Membrane Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India
    Biochemistry 45:14726-39. 2006
  9. ncbi Allelic variants of ABC drug transporter Cdr1p in clinical isolates of Candida albicans
    Absarul Haque
    Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi 110067, India
    Biochem Biophys Res Commun 352:491-7. 2007
  10. pmc Serum repressing efflux pump CDR1 in Candida albicans
    Yun Liang Yang
    Department of Biological Science and Technology, National Chiao Tung University, Hsinchu
    BMC Mol Biol 7:22. 2006

Scientific Experts

  • Yun Liang Yang
  • Rajendra Prasad
  • Versha Rai
  • Sudhanshu Shukla
  • Shipra Shukla
  • Antresh Kumar
  • Suneet Shukla
  • Suresh V Ambudkar
  • Manisha Gaur
  • Koichi Tanabe
  • Luiz R Basso
  • Gauranga Mukhopadhyay
  • Nidhi Puri
  • Absarul Haque
  • Sneha Sudha Komath
  • Alix Coste
  • Chung Yeng Looi
  • Atsushi Okawada
  • Minoru Nagi
  • Masakazu Niimi
  • Brian C Monk
  • Yoshitsugu Miyazaki
  • Ann R Holmes
  • Richard D Cannon
  • Vipin Yadav
  • Erwin Lamping
  • Ajeet Mandal
  • Brian Wong
  • Yuxin Mao
  • Charles E Gast
  • Monika Sharma
  • Anant K Menon
  • Birendra Singh Bahal
  • Ali Abdul Lattif
  • Preeti Saini
  • Dibyendu Banerjee
  • Vincent Turner
  • Anna Selmecki
  • Dominique Sanglard
  • Françoise Ischer
  • Anja Forche
  • Joachim Morschhäuser
  • Judith Berman
  • Jacques Bille
  • Pei Pei Chong
  • Rozita Rosli
  • Kee Peng Ng
  • Emily Christine D' Silva
  • Heng Fong Seow

Detail Information

Publications12

  1. pmc Candida drug resistance protein 1, a major multidrug ATP binding cassette transporter of Candida albicans, translocates fluorescent phospholipids in a reconstituted system
    Sudhanshu Shukla
    Membrane Biology Laboratory, School of Life Sciences, and Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi 110067, India
    Biochemistry 46:12081-90. 2007
    ..We note that only a few members of the ABC superfamily of Candida have a well-defined role as drug exporters; thus, lipid translocation mediated by Cdr1p could reflect its cellular function...
  2. doi Chimeras of Candida albicans Cdr1p and Cdr2p reveal features of pleiotropic drug resistance transporter structure and function
    Koichi Tanabe
    Department of Bioactive Molecules, National Institute of Infectious Diseases, Tokyo 162 8640, Japan
    Mol Microbiol 82:416-33. 2011
    ..The NBDs, in particular NBD1 and/or the ∼150 amino acids N-terminal to NBD1, can also modulate the substrate specificities of CaCdr1p and CaCdr2p...
  3. pmc Ncb2 is involved in activated transcription of CDR1 in azole-resistant clinical isolates of Candida albicans
    Shipra Shukla
    Special Centre for Molecular Medicine and Membrane Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India
    Eukaryot Cell 10:1357-66. 2011
    We recently demonstrated that CDR1 overexpression in azole-resistant isolates of Candida albicans is due to its enhanced transcriptional activation and increased mRNA stability...
  4. pmc Divergent signature motifs of nucleotide binding domains of ABC multidrug transporter, CaCdr1p of pathogenic Candida albicans, are functionally asymmetric and noninterchangeable
    Antresh Kumar
    Membrane Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India
    Biochim Biophys Acta 1798:1757-66. 2010
    ..Taken together, our data suggest that the signature motifs of CaCdr1p, whether it is divergent or conserved, are nonexchangeable and are functionally critical for ATP hydrolysis...
  5. pmc Fluconazole transport into Candida albicans secretory vesicles by the membrane proteins Cdr1p, Cdr2p, and Mdr1p
    Luiz R Basso
    Division of Infectious Diseases, Department of Medicine, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, Portland, OR 97239, USA
    Eukaryot Cell 9:960-70. 2010
    A major cause of azole resistance in Candida albicans is overexpression of CDR1, CDR2, and/or MDR1, which encode plasma membrane efflux pumps...
  6. pmc The amino acid residues of transmembrane helix 5 of multidrug resistance protein CaCdr1p of Candida albicans are involved in substrate specificity and drug transport
    Nidhi Puri
    Membrane Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India
    Biochim Biophys Acta 1788:1752-61. 2009
    ..TMS 5 residues of CaCdr1p thus not only impart substrate specificity but also selectively act as a communication link between ATP hydrolysis and drug transport...
  7. doi A novel catalytic mechanism for ATP hydrolysis employed by the N-terminal nucleotide-binding domain of Cdr1p, a multidrug ABC transporter of Candida albicans
    Versha Rai
    Membrane Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India
    Biochim Biophys Acta 1778:2143-53. 2008
    ..Taken together our results imply that the uniquely placed residues in NBD-512 have acquired critical roles in ATP catalysis, which drives drug extrusion...
  8. pmc Conserved Asp327 of walker B motif in the N-terminal nucleotide binding domain (NBD-1) of Cdr1p of Candida albicans has acquired a new role in ATP hydrolysis
    Versha Rai
    Membrane Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India
    Biochemistry 45:14726-39. 2006
    ....
  9. ncbi Allelic variants of ABC drug transporter Cdr1p in clinical isolates of Candida albicans
    Absarul Haque
    Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi 110067, India
    Biochem Biophys Res Commun 352:491-7. 2007
    ..We have analyzed its sequence in several azole resistant clinical isolates to evaluate the allelic variation within CDR1 gene and to relate it to its functional activity...
  10. pmc Serum repressing efflux pump CDR1 in Candida albicans
    Yun Liang Yang
    Department of Biological Science and Technology, National Chiao Tung University, Hsinchu
    BMC Mol Biol 7:22. 2006
    ..Overexpression of CDR1, an efflux pump, has been proposed as a major mechanism contributing to the drug resistance in Candida albicans...
  11. pmc A mutation in Tac1p, a transcription factor regulating CDR1 and CDR2, is coupled with loss of heterozygosity at chromosome 5 to mediate antifungal resistance in Candida albicans
    Alix Coste
    Institute of Microbiology, University Hospital Lausanne, Switzerland
    Genetics 172:2139-56. 2006
    ..situated near the mating-type locus on chromosome 5, is necessary for the upregulation of the ABC-transporter genes CDR1 and CDR2, which mediate azole resistance...
  12. ncbi Increased expression and hotspot mutations of the multidrug efflux transporter, CDR1 in azole-resistant Candida albicans isolates from vaginitis patients
    Chung Yeng Looi
    Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia
    FEMS Microbiol Lett 249:283-9. 2005
    The aims of our research were to investigate the gene expression of the multidrug efflux transporter, CDR1 and the major drug facilitator superfamily transporter, MDR1 gene in azole drug-resistant Candida albicans and Candida glabrata ..