major surface protein 2

Summary

Gene Symbol: major surface protein 2
Description: major surface protein 2
Species: Anaplasma marginale str. St. Maries

Top Publications

  1. pmc Expression of major surface protein 2 antigenic variants during acute Anaplasma marginale rickettsemia
    G Eid
    Department of Infectious Diseases, University of Florida, Gainesville, USA
    Infect Immun 64:836-41. 1996
  2. pmc Antigenic variation of Anaplasma marginale by expression of MSP2 mosaics
    A F Barbet
    Department of Pathobiology, College of Veterinary Medicine, University of Florida, Gainesville, Florida 32611 0880, USA
    Infect Immun 68:6133-8. 2000
  3. ncbi The hypervariable region of Anaplasma marginale major surface protein 2 (MSP2) contains multiple immunodominant CD4+ T lymphocyte epitopes that elicit variant-specific proliferative and IFN-gamma responses in MSP2 vaccinates
    Wendy C Brown
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164, USA
    J Immunol 170:3790-8. 2003
  4. pmc The immunoprotective Anaplasma marginale major surface protein 2 is encoded by a polymorphic multigene family
    G H Palmer
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164 7040
    Infect Immun 62:3808-16. 1994
  5. pmc Expression of Anaplasma marginale major surface protein 2 operon-associated proteins during mammalian and arthropod infection
    CHRISTIANE V LOHR
    Program in Vector Borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164 7040, USA
    Infect Immun 70:6005-12. 2002

Scientific Experts

  • WENDY CATHERINE BROWN
  • A F Barbet
  • CHRISTIANE V LOHR
  • G Eid
  • G H Palmer
  • Guy H Palmer
  • Thea Molad
  • Varda Shkap
  • Kelly A Brayton
  • T F McElwain
  • D M French
  • A M Lundgren
  • T C McGuire

Detail Information

Publications5

  1. pmc Expression of major surface protein 2 antigenic variants during acute Anaplasma marginale rickettsemia
    G Eid
    Department of Infectious Diseases, University of Florida, Gainesville, USA
    Infect Immun 64:836-41. 1996
    Antigenic variants of Anaplasma marginale major surface protein 2 (MSP-2), a target of protective immune responses, have been detected by use of copy-specific monoclonal antibodies reactive with some, but not all, organisms during acute ..
  2. pmc Antigenic variation of Anaplasma marginale by expression of MSP2 mosaics
    A F Barbet
    Department of Pathobiology, College of Veterinary Medicine, University of Florida, Gainesville, Florida 32611 0880, USA
    Infect Immun 68:6133-8. 2000
    ..marginale. A potential mechanism for persistence is segmental gene conversion of the expression site to link hypervariable msp2 sequences to the promoter and polycistron...
  3. ncbi The hypervariable region of Anaplasma marginale major surface protein 2 (MSP2) contains multiple immunodominant CD4+ T lymphocyte epitopes that elicit variant-specific proliferative and IFN-gamma responses in MSP2 vaccinates
    Wendy C Brown
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164, USA
    J Immunol 170:3790-8. 2003
    b>Major surface protein 2 (MSP2) is an immunodominant outer membrane protein of Anaplasma marginale and Anaplasma phagocytophilum pathogens that cause bovine anaplasmosis and human granulocytic ehrlichiosis, respectively...
  4. pmc The immunoprotective Anaplasma marginale major surface protein 2 is encoded by a polymorphic multigene family
    G H Palmer
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164 7040
    Infect Immun 62:3808-16. 1994
    ..These findings support the hypothesis that A. marginale surface proteins are targets of protective immune responses but are antigenically polymorphic...
  5. pmc Expression of Anaplasma marginale major surface protein 2 operon-associated proteins during mammalian and arthropod infection
    CHRISTIANE V LOHR
    Program in Vector Borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164 7040, USA
    Infect Immun 70:6005-12. 2002
    The antigenically variant major surface protein 2 (MSP2) of Anaplasma marginale is expressed from a 3.5-kb operon that contains, in a 5'-to-3' direction, four open reading frames, opag3, opag2, opag1, and msp2...