Affiliation: University of California
Wesseling Perry K. FGF-23 in bone biology. Pediatr Nephrol. 2010;25:603-8 pubmed publisher
..Thus, dysregulation of osteocytic proteins occur very early in the course of CKD and appear to be central to altered bone and mineral metabolism in this patient population. ..
Wesseling Perry K, Pereira R, Tseng C, Elashoff R, Zaritsky J, Yadin O, et al
. Early skeletal and biochemical alterations in pediatric chronic kidney disease. Clin J Am Soc Nephrol. 2012;7:146-52 pubmed publisher
Wesseling K, Bakkaloglu S, SALUSKY I. Chronic kidney disease mineral and bone disorder in children. Pediatr Nephrol. 2008;23:195-207 pubmed
Wesseling Perry K, Tsai E, Ettenger R, Juppner H, Salusky I. Mineral abnormalities and long-term graft function in pediatric renal transplant recipients: a role for FGF-23?. Nephrol Dial Transplant. 2011;26:3779-84 pubmed publisher
..FGF-23 levels may be associated with increased risk for deterioration of kidney function and episodes of rejection. ..
Wesseling Perry K, Juppner H. The osteocyte in CKD: new concepts regarding the role of FGF23 in mineral metabolism and systemic complications. Bone. 2013;54:222-9 pubmed publisher
..Further studies are critically needed to identify the initial trigger for abnormalities of skeletal mineralization and turnover as well as the potential effects that current therapeutic options may have on osteocyte biology. ..
Wesseling Perry K. Defective skeletal mineralization in pediatric CKD. Curr Osteoporos Rep. 2015;13:98-105 pubmed publisher
..Further studies are critically needed to identify the initial trigger for abnormalities of skeletal mineralization as well as the potential effects that current therapeutic options may have on osteocyte biology and bone mineralization. ..
Wesseling Perry K, Harkins G, Wang H, Sahney S, Gales B, Elashoff R, et al
. Response of different PTH assays to therapy with sevelamer or CaCO3 and active vitamin D sterols. Pediatr Nephrol. 2009;24:1355-61 pubmed publisher
..The PTH values obtained by first- and second-generation PTH-IMAs correlated closely throughout therapy and the response of PTH was similar to both PTH-IMAs, despite differences in serum calcium levels. ..
Wesseling Perry K, Pereira R, Sahney S, Gales B, Wang H, Elashoff R, et al
. Calcitriol and doxercalciferol are equivalent in controlling bone turnover, suppressing parathyroid hormone, and increasing fibroblast growth factor-23 in secondary hyperparathyroidism. Kidney Int. 2011;79:112-9 pubmed publisher
..Sevelamer allows the use of higher doses of vitamin D. Implications of these changes on bone and cardiovascular biology remain to be established. ..
Pereira R, Bischoff D, YAMAGUCHI D, Salusky I, Wesseling Perry K. Micro-CT in the Assessment of Pediatric Renal Osteodystrophy by Bone Histomorphometry. Clin J Am Soc Nephrol. 2016;11:481-7 pubmed publisher
..Thus, bone mineralization may be accurately assessed by Î¼CT of bone biopsy cores. Additional studies are warranted to define the value of high-resolution CT in the prediction of bone mineralization in vivo. ..