Rajiv Sharma

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. request reprint
    Sharma R, Tun N, Grayson D. Depolarization induces downregulation of DNMT1 and DNMT3a in primary cortical cultures. Epigenetics. 2008;3:74-80 pubmed
    ..Our results support the idea that a reduction in DNA methyltransferase activity in the activated and depolarized neuron could contribute to the enhanced intensity and multiplicity of gene expression frequently reported. ..
  2. Chase K, Rosen C, Gin H, Bjorkquist O, Feiner B, Marvin R, et al. Metabolic and inflammatory genes in schizophrenia. Psychiatry Res. 2015;225:208-211 pubmed publisher
    ....
  3. Chase K, Cone J, Rosen C, Sharma R. The value of interleukin 6 as a peripheral diagnostic marker in schizophrenia. BMC Psychiatry. 2016;16:152 pubmed publisher
    ..Future utilization of peripheral IL-6 mRNA levels could be clinically useful during an initial diagnosis and help tailor individualized treatment plans for patients with schizophrenia. ..
  4. Melbourne J, Rosen C, Feiner B, Sharma R. C4A mRNA expression in PBMCs predicts the presence and severity of delusions in schizophrenia and bipolar disorder with psychosis. Schizophr Res. 2018;: pubmed publisher
    ..These findings are noteworthy given recent findings that demonstrate a critical role for complement proteins in synaptic pruning, alterations of which are proposed to contribute to psychopathology in psychosis. ..
  5. Chase K, Rosen C, Rubin L, Feiner B, Bodapati A, Gin H, et al. Evidence of a sex-dependent restrictive epigenome in schizophrenia. J Psychiatr Res. 2015;65:87-94 pubmed publisher
    ..The histone methyltransferases measured here could be potential future therapeutic targets for small molecule pharmacology. ..
  6. Sharma R, Grayson D, Gavin D. Histone deactylase 1 expression is increased in the prefrontal cortex of schizophrenia subjects: analysis of the National Brain Databank microarray collection. Schizophr Res. 2008;98:111-7 pubmed
    ..These findings provide additional support for the proposal that epigenetic factors are operative in the brain pathology of patients with schizophrenia. ..
  7. Chase K, Feiner B, Rosen C, Gavin D, Sharma R. Characterization of peripheral cannabinoid receptor expression and clinical correlates in schizophrenia. Psychiatry Res. 2016;245:346-353 pubmed publisher
    ..These results continue to support dysregulation of particular aspects of the endocannabinoid signaling system in participants with schizophrenia selected for the self-reported absence of marijuana abuse/dependence. ..
  8. Melbourne J, Chase K, Feiner B, Rosen C, Sharma R. Long non-coding and endogenous retroviral RNA levels are associated with proinflammatory cytokine mRNA expression in peripheral blood cells: Implications for schizophrenia. Psychiatry Res. 2017;: pubmed publisher
    ....

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Collaborators

Detail Information

Publications8

  1. request reprint
    Sharma R, Tun N, Grayson D. Depolarization induces downregulation of DNMT1 and DNMT3a in primary cortical cultures. Epigenetics. 2008;3:74-80 pubmed
    ..Our results support the idea that a reduction in DNA methyltransferase activity in the activated and depolarized neuron could contribute to the enhanced intensity and multiplicity of gene expression frequently reported. ..
  2. Chase K, Rosen C, Gin H, Bjorkquist O, Feiner B, Marvin R, et al. Metabolic and inflammatory genes in schizophrenia. Psychiatry Res. 2015;225:208-211 pubmed publisher
    ....
  3. Chase K, Cone J, Rosen C, Sharma R. The value of interleukin 6 as a peripheral diagnostic marker in schizophrenia. BMC Psychiatry. 2016;16:152 pubmed publisher
    ..Future utilization of peripheral IL-6 mRNA levels could be clinically useful during an initial diagnosis and help tailor individualized treatment plans for patients with schizophrenia. ..
  4. Melbourne J, Rosen C, Feiner B, Sharma R. C4A mRNA expression in PBMCs predicts the presence and severity of delusions in schizophrenia and bipolar disorder with psychosis. Schizophr Res. 2018;: pubmed publisher
    ..These findings are noteworthy given recent findings that demonstrate a critical role for complement proteins in synaptic pruning, alterations of which are proposed to contribute to psychopathology in psychosis. ..
  5. Chase K, Rosen C, Rubin L, Feiner B, Bodapati A, Gin H, et al. Evidence of a sex-dependent restrictive epigenome in schizophrenia. J Psychiatr Res. 2015;65:87-94 pubmed publisher
    ..The histone methyltransferases measured here could be potential future therapeutic targets for small molecule pharmacology. ..
  6. Sharma R, Grayson D, Gavin D. Histone deactylase 1 expression is increased in the prefrontal cortex of schizophrenia subjects: analysis of the National Brain Databank microarray collection. Schizophr Res. 2008;98:111-7 pubmed
    ..These findings provide additional support for the proposal that epigenetic factors are operative in the brain pathology of patients with schizophrenia. ..
  7. Chase K, Feiner B, Rosen C, Gavin D, Sharma R. Characterization of peripheral cannabinoid receptor expression and clinical correlates in schizophrenia. Psychiatry Res. 2016;245:346-353 pubmed publisher
    ..These results continue to support dysregulation of particular aspects of the endocannabinoid signaling system in participants with schizophrenia selected for the self-reported absence of marijuana abuse/dependence. ..
  8. Melbourne J, Chase K, Feiner B, Rosen C, Sharma R. Long non-coding and endogenous retroviral RNA levels are associated with proinflammatory cytokine mRNA expression in peripheral blood cells: Implications for schizophrenia. Psychiatry Res. 2017;: pubmed publisher
    ....