Patrick Seale


Affiliation: University of Pennsylvania
Country: USA


  1. Harms M, Lim H, Ho Y, Shapira S, Ishibashi J, Rajakumari S, et al. PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program. Genes Dev. 2015;29:298-307 pubmed publisher
    ..Together, these data indicate that PRDM16 controls chromatin architecture and superenhancer activity in BAT. ..
  2. Seale P. Transcriptional Regulatory Circuits Controlling Brown Fat Development and Activation. Diabetes. 2015;64:2369-75 pubmed publisher
    ..This review summarizes recent advances in our understanding of the transcriptional mechanisms that control brown and beige fat cell development. ..
  3. Harms M, Ishibashi J, Wang W, Lim H, Goyama S, Sato T, et al. Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice. Cell Metab. 2014;19:593-604 pubmed publisher
    ..Together, these results show that Prdm16 and Prdm3 control postnatal BAT identity and function. ..
  4. Kajimura S, Spiegelman B, Seale P. Brown and Beige Fat: Physiological Roles beyond Heat Generation. Cell Metab. 2015;22:546-59 pubmed publisher
    ..We aim to discuss recent insights regarding the developmental lineages, molecular regulation, and new functions for brown and beige adipocytes. ..
  5. Seale P, Conroe H, Estall J, Kajimura S, Frontini A, Ishibashi J, et al. Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. J Clin Invest. 2011;121:96-105 pubmed publisher
    ..These results demonstrate that Prdm16 is a cell-autonomous determinant of a brown fat-like gene program and thermogenesis in subcutaneous adipose tissues. ..
  6. Wang W, Kissig M, Rajakumari S, Huang L, Lim H, Won K, et al. Ebf2 is a selective marker of brown and beige adipogenic precursor cells. Proc Natl Acad Sci U S A. 2014;111:14466-71 pubmed publisher
    ..Altogether, these results indicate that Ebf2 specifically marks and regulates the molecular profile of brown preadipose cells. ..
  7. Kissig M, Ishibashi J, Harms M, Lim H, Stine R, Won K, et al. PRDM16 represses the type I interferon response in adipocytes to promote mitochondrial and thermogenic programing. EMBO J. 2017;36:1528-1542 pubmed publisher
    ..Together, these data indicate that PRDM16 diminishes responsiveness to type I IFN in adipose cells to promote thermogenic and mitochondrial function. ..