William G Schrage

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc Roles of nitric oxide synthase and cyclooxygenase in leg vasodilation and oxygen consumption during prolonged low-intensity exercise in untrained humans
    William G Schrage
    Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA
    J Appl Physiol (1985) 109:768-77. 2010
  2. pmc Ageing reduces nitric-oxide- and prostaglandin-mediated vasodilatation in exercising humans
    William G Schrage
    Department of Kinesiology, 1149A Natatorium, University of Wisconsin, Madison, WI 53706, USA
    J Physiol 579:227-36. 2007
  3. pmc Heterogeneous vascular responses to hypoxic forearm exercise in young and older adults
    Jacqueline K Limberg
    Department of Kinesiology, School of Education, University of Wisconsin, 2000 Observatory Avenue, Rm 1149A, Madison, WI 53703, USA
    Eur J Appl Physiol 112:3087-95. 2012
  4. ncbi request reprint Effects of combined inhibition of ATP-sensitive potassium channels, nitric oxide, and prostaglandins on hyperemia during moderate exercise
    William G Schrage
    Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA
    J Appl Physiol (1985) 100:1506-12. 2006
  5. ncbi request reprint Arterial baroreflex control of heart rate during exercise in postural tachycardia syndrome
    Shizue Masuki
    Department of Anesthesiology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    J Appl Physiol 103:1136-42. 2007
  6. pmc Microvascular function in younger adults with obesity and metabolic syndrome: role of oxidative stress
    Jacqueline K Limberg
    Department of Kinesiology, School of Education, University of Wisconsin, Madison, Wisconsin
    Am J Physiol Heart Circ Physiol 305:H1230-7. 2013
  7. pmc Alpha-adrenergic control of blood flow during exercise: effect of sex and menstrual phase
    Jacqueline K Limberg
    Department of Kinesiology, School of Education, University of Wisconsin, Madison, WI 53706, USA
    J Appl Physiol (1985) 109:1360-8. 2010
  8. pmc Local inhibition of nitric oxide and prostaglandins independently reduces forearm exercise hyperaemia in humans
    William G Schrage
    Department Anaesthesiology, Mayo Clinic, Rochester, MN 55905, USA
    J Physiol 557:599-611. 2004
  9. pmc Systemic hypoxia and vasoconstrictor responsiveness in exercising human muscle
    Brad W Wilkins
    Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA
    J Appl Physiol (1985) 101:1343-50. 2006
  10. ncbi request reprint Reduced stroke volume during exercise in postural tachycardia syndrome
    Shizue Masuki
    Department of Anesthesiology, Mayo Clinic Foundation, Rochester, MN 55905, USA
    J Appl Physiol 103:1128-35. 2007

Research Grants

Collaborators

Detail Information

Publications34

  1. pmc Roles of nitric oxide synthase and cyclooxygenase in leg vasodilation and oxygen consumption during prolonged low-intensity exercise in untrained humans
    William G Schrage
    Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA
    J Appl Physiol (1985) 109:768-77. 2010
    ..Furthermore, NOS and COX do not appear to influence muscle VO2 in untrained healthy young adults...
  2. pmc Ageing reduces nitric-oxide- and prostaglandin-mediated vasodilatation in exercising humans
    William G Schrage
    Department of Kinesiology, 1149A Natatorium, University of Wisconsin, Madison, WI 53706, USA
    J Physiol 579:227-36. 2007
    ..Lower exercise hyperaemia in older humans may be mediated in part by less NO- and PG-mediated vasodilatation during exercise...
  3. pmc Heterogeneous vascular responses to hypoxic forearm exercise in young and older adults
    Jacqueline K Limberg
    Department of Kinesiology, School of Education, University of Wisconsin, 2000 Observatory Avenue, Rm 1149A, Madison, WI 53703, USA
    Eur J Appl Physiol 112:3087-95. 2012
    ..Results suggest unique individual differences exist in factors regulating vascular responses to hypoxia...
  4. ncbi request reprint Effects of combined inhibition of ATP-sensitive potassium channels, nitric oxide, and prostaglandins on hyperemia during moderate exercise
    William G Schrage
    Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA
    J Appl Physiol (1985) 100:1506-12. 2006
    ..However, some subjects are sensitive to triple blockade, but they are able to restore FBF acutely during exercise. Future studies are required to determine the nature of these compensatory mechanisms in the affected individuals...
  5. ncbi request reprint Arterial baroreflex control of heart rate during exercise in postural tachycardia syndrome
    Shizue Masuki
    Department of Anesthesiology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    J Appl Physiol 103:1136-42. 2007
    ..These results suggest that the tachycardia during exercise in POTS was not due to abnormal baroreflex control of HR...
  6. pmc Microvascular function in younger adults with obesity and metabolic syndrome: role of oxidative stress
    Jacqueline K Limberg
    Department of Kinesiology, School of Education, University of Wisconsin, Madison, Wisconsin
    Am J Physiol Heart Circ Physiol 305:H1230-7. 2013
    ..267). These results suggest that obese and MetSyn adults exhibit preserved endothelium-dependent vasodilation with reduced dependence on prostacyclin and are consistent with an upregulation of compensatory vascular control mechanisms. ..
  7. pmc Alpha-adrenergic control of blood flow during exercise: effect of sex and menstrual phase
    Jacqueline K Limberg
    Department of Kinesiology, School of Education, University of Wisconsin, Madison, WI 53706, USA
    J Appl Physiol (1985) 109:1360-8. 2010
    ....
  8. pmc Local inhibition of nitric oxide and prostaglandins independently reduces forearm exercise hyperaemia in humans
    William G Schrage
    Department Anaesthesiology, Mayo Clinic, Rochester, MN 55905, USA
    J Physiol 557:599-611. 2004
    ..PGs contribute modestly and transiently, suggesting a redundant signal compensates for the loss of vasodilating PGs, and (3). NO and PG signals appear to contribute independently to forearm exercise hyperaemia...
  9. pmc Systemic hypoxia and vasoconstrictor responsiveness in exercising human muscle
    Brad W Wilkins
    Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA
    J Appl Physiol (1985) 101:1343-50. 2006
    ..22 +/- 4%), and at 20% exercise (-22 +/- 5 vs. -14 +/- 4%) between hypoxia and normoxia, respectively. Thus sympatholysis is not augmented by moderate hypoxia nor does it contribute to the increased blood flow during hypoxic exercise...
  10. ncbi request reprint Reduced stroke volume during exercise in postural tachycardia syndrome
    Shizue Masuki
    Department of Anesthesiology, Mayo Clinic Foundation, Rochester, MN 55905, USA
    J Appl Physiol 103:1128-35. 2007
    ..60), and 75 W (R(2) = 0.32) (P < 0.01). These results suggest that greater elevation in HR in POTS patients during exercise, especially while upright, was secondary to reduced SV and associated with exercise intolerance...
  11. pmc Cyclooxygenase-derived vasoconstriction restrains hypoxia-mediated cerebral vasodilation in young adults with metabolic syndrome
    John W Harrell
    Bruno Balke Biodynamics Laboratory, Department of Kinesiology, University of Wisconsin Madison, Madison, Wisconsin
    Am J Physiol Heart Circ Physiol 306:H261-9. 2014
    ..These data indicate increased production of vasoconstrictor prostaglandins restrains hypoxic cerebral vasodilation in MetSyn, preventing them from responding appropriately to this important physiological stressor. ..
  12. pmc Effect of obesity and metabolic syndrome on hypoxic vasodilation
    Jacqueline K Limberg
    Department of Kinesiology, School of Education, University of Wisconsin, 1149 Natatorium, Madison, WI 53706, USA
    Eur J Appl Physiol 112:699-709. 2012
    ..Individual hypoxic vasodilatory responses were variable, suggesting diversity in vascular control...
  13. pmc Altered neurovascular control of the resting circulation in human metabolic syndrome
    Jacqueline K Limberg
    School of Education, Department of Kinesiology, University of Wisconsin Madison, Madison, WI 53076, USA
    J Physiol 590:6109-19. 2012
    ....
  14. doi request reprint Muscle blood flow responses to dynamic exercise in young obese humans
    Jacqueline K Limberg
    Dept of Kinesiology, School of Education, Univ of Wisconsin, Madison, WI 53706, USA
    J Appl Physiol (1985) 108:349-55. 2010
    ..05). These results were confirmed when relative blood flow was expressed at average relative workloads. In conclusion, our results show that obese subjects exhibited preserved FBF and LBF during dynamic exercise...
  15. ncbi request reprint Agonist-dependent variablity of contributions of nitric oxide and prostaglandins in human skeletal muscle
    William G Schrage
    Dept of Anesthesiology, Joseph 4 184W, Mayo Clinic, Rochester, MN 55905, USA
    J Appl Physiol (1985) 98:1251-7. 2005
    ..The NOS + COX-independent dilation does not appear sensitive to feedback inhibition from NO in the human forearm...
  16. ncbi request reprint Effects of midodrine on exercise-induced hypotension and blood pressure recovery in autonomic failure
    William G Schrage
    Department of Anesthesia Research, Joseph 4 184W, Mayo Clinic, Rochester, MN 55905, USA
    J Appl Physiol (1985) 97:1978-84. 2004
    ..02). We conclude midodrine improves blood pressure and TPR during exercise and dramatically improves the recovery of MAP after exercise...
  17. pmc Greater Beta-Adrenergic Receptor Mediated Vasodilation in Women Using Oral Contraceptives
    Jacqueline K Limberg
    Department of Kinesiology, University of Wisconsin Madison, WI, USA
    Front Physiol 7:215. 2016
    ....
  18. ncbi request reprint Excessive heart rate response to orthostatic stress in postural tachycardia syndrome is not caused by anxiety
    Shizue Masuki
    Dept of Anesthesiology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    J Appl Physiol 102:896-903. 2007
    ..1). These results suggest that the HR response to orthostatic stress in POTS patients is not caused by anxiety but that it is a physiological response that maintains arterial pressure during venous pooling...
  19. pmc Exercise hyperemia and vasoconstrictor responses in humans with cystic fibrosis
    William G Schrage
    Department of Anesthesiology and General Clinical Research Center, Mayo Clinic, Rochester, MN 55905, USA
    J Appl Physiol (1985) 99:1866-71. 2005
    ..22). Our results suggest that ATP released from the deformation of erythrocytes is not an obligatory signal for exercise hyperemia in human skeletal muscle...
  20. pmc Potentiation of the NO-cGMP pathway and blood flow responses during dynamic exercise in healthy humans
    Jacqueline K Limberg
    Department of Anesthesiology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN, 55905, USA
    Eur J Appl Physiol . 2016
    ..We further hypothesized any effect of SDF on exercise hyperemia would be abolished with intra-arterial infusion of the NO synthase (NOS) inhibitor L-NG-monomethyl arginine (L-NMMA)...
  21. pmc Exercise vasodilation is greater in women: contributions of nitric oxide synthase and cyclooxygenase
    J Mikhail Kellawan
    Bruno Balke Biodynamics Lab, Department of Kinesiology, School of Education, University of Wisconsin Madison, 1141A Natatorium, 2000 Observatory Drive, Madison, WI, 53706, USA
    Eur J Appl Physiol 115:1735-46. 2015
    ..We hypothesized exercise vasodilation would be greater in women due to nitric oxide synthase (NOS) and cyclooxygenase (COX) signaling...
  22. pmc β-Adrenergic-mediated vasodilation in young men and women: cyclooxygenase restrains nitric oxide synthase
    Jacqueline K Limberg
    Department of Kinesiology, University of Wisconsin, Madison, Wisconsin
    Am J Physiol Heart Circ Physiol 310:H756-64. 2016
    ....
  23. pmc Exercise-mediated vasodilation in human obesity and metabolic syndrome: effect of acute ascorbic acid infusion
    Jacqueline K Limberg
    Department of Kinesiology, School of Education, University of Wisconsin, and
    Am J Physiol Heart Circ Physiol 307:H840-7. 2014
    ..However, systemic inflammation may limit the MRT to exercise, which can be improved with AA. ..
  24. pmc Respiratory influences on muscle sympathetic nerve activity and vascular conductance in the steady state
    Jacqueline K Limberg
    Bruno Balke Biodynamics Laboratory, Department of Kinesiology, School of Education, University of Wisconsin, Madison, WI, USA
    Am J Physiol Heart Circ Physiol 304:H1615-23. 2013
    ..those who maintained normocapnia. These findings challenge the notion that slow, deep breathing lowers arterial pressure by suppressing steady-state sympathetic outflow...
  25. doi request reprint Quantitative cerebrovascular 4D flow MRI at rest and during hypercapnia challenge
    J Mikhail Kellawan
    Department of Kinesiology, University of Wisconsin Madison, Madison, WI, USA Electronic address
    Magn Reson Imaging 34:422-8. 2016
    ..The purpose of this study was to develop an imaging protocol to simultaneously measure pulsatile flow in the circle of Willis as well as the carotid and vertebrate arteries at rest and during increased CO2 (hypercapnia)...
  26. pmc Neural control of blood flow during exercise in human metabolic syndrome
    Jacqueline K Limberg
    School of Education, Department of Kinesiology, University of Wisconsin Madison, Madison, WI 53706, USA
    Exp Physiol 99:1191-202. 2014
    ..These results suggest that adults with MetSyn exhibit compensatory vascular control mechanisms capable of preserving blood flow responses to exercise in the face of augmented sympathetic adrenergic activity. ..
  27. pmc Impaired hypoxic cerebral vasodilation in younger adults with metabolic syndrome
    John W Harrell
    Department of Kinesiology, University of Wisconsin, Madison, WI 53706, USA
    Diab Vasc Dis Res 10:135-42. 2013
    ..These findings provide novel insight into cerebrovascular disease onset in MetSyn adults...
  28. pmc Dietary sodium restriction and beta2-adrenergic receptor polymorphism modulate cardiovascular function in humans
    John H Eisenach
    Department of Anaesthesiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Physiol 574:955-65. 2006
    ..This study provides evidence that dietary Na+ modulates effects of the Arg16Gly polymorphism on cardiovascular function...
  29. pmc Cerebral blood flow regulation in women across menstrual phase: differential contribution of cyclooxygenase to basal, hypoxic, and hypercapnic vascular tone
    Garrett L Peltonen
    Bruno Balke Biodynamics Laboratory, Department of Kinesiology, University of Wisconsin Madison, Madison, Wisconsin
    Am J Physiol Regul Integr Comp Physiol 311:R222-31. 2016
    ..These data provide new mechanistic insight into anterior CBF regulation across menstrual phases and contribute to our understanding of CBF regulation in women. ..
  30. pmc Increased leg blood flow and improved femoral artery shear patterns in metabolic syndrome after a diet and exercise programme
    Jacqueline K Limberg
    Department of Kinesiology, School of Education, University of Wisconsin Madison, Madison, WI, USA
    Clin Physiol Funct Imaging 34:282-9. 2014
    ....
  31. ncbi request reprint Insulin resistance is associated with lower arterial blood flow and reduced cortical perfusion in cognitively asymptomatic middle-aged adults
    Siobhan M Hoscheidt
    Wisconsin Alzheimer s Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    J Cereb Blood Flow Metab . 2016
    ..Findings provide novel evidence for an uncoupling of macrovascular blood flow and microvascular perfusion among individuals with higher IR in midlife...
  32. ncbi request reprint Mechanisms of flow and ACh-induced dilation in rat soleus arterioles are altered by hindlimb unweighting
    William G Schrage
    Department of Physiology, University of Missouri, Columbia, Missouri 65211, USA
    J Appl Physiol 92:901-11. 2002
    ..In soleus 2As, ACh-induced dilation was preserved after 2-wk HLU but the contribution of NOS in mediating ACh-induced dilation was increased...
  33. doi request reprint Not a search in vein: novel stimulus for vascular dysfunction after simulated microgravity
    William G Schrage
    J Appl Physiol 104:1257-8. 2008
  34. ncbi request reprint Short-term training enhances endothelium-dependent dilation of coronary arteries, not arterioles
    M Harold Laughlin
    Department of Veterinary Biomedical Sciences, University of Missouri, Columbia 65211, USA
    J Appl Physiol (1985) 94:234-44. 2003
    ..We conclude that pigs exhibit increases in EDD of conduit arteries, but not in coronary arterioles, at the onset of exercise training. These adaptations in pigs do not appear to be mediated by alterations in eNOS or SOD-1 expression...

Research Grants1

  1. Muscle Pump and Chemical Dilation in Exercise Hyperemia
    William Schrage; Fiscal Year: 2004
    ..The strength of the proposed experiments is that we will manipulate both mechanical and chemical factors and assess their combined effects on muscle blood flow during acute and steady state exercise in humans. ..