Siba K Samal


Affiliation: University of Maryland
Country: USA


  1. Shirvani E, Paldurai A, Manoharan V, Varghese B, Samal S. A Recombinant Newcastle Disease Virus (NDV) Expressing S Protein of Infectious Bronchitis Virus (IBV) Protects Chickens against IBV and NDV. Sci Rep. 2018;8:11951 pubmed publisher
    ..These results suggest that the rNDV expressing the S protein of IBV is a safe and effective bivalent vaccine candidate for both IBV and NDV. ..
  2. Manoharan V, Khattar S, LaBranche C, Montefiori D, Samal S. Modified Newcastle Disease virus as an improved vaccine vector against Simian Immunodeficiency virus. Sci Rep. 2018;8:8952 pubmed publisher
    ..6 and tier 1B SIVmac251/M766 strains. This study suggests that our novel modified NDV vectors are safe and immunogenic and can be used as vaccine vector to control HIV. ..
  3. Kim S, Paldurai A, Xiao S, Collins P, Samal S. Modified Newcastle disease virus vectors expressing the H5 hemagglutinin induce enhanced protection against highly pathogenic H5N1 avian influenza virus in chickens. Vaccine. 2014;32:4428-35 pubmed publisher
    ..Our findings suggest that this modified rNDV can be used safely as a vaccine vector with enhanced replication, expression, and protective efficacy in avian species, and potentially in humans. ..
  4. Khattar S, Manoharan V, Bhattarai B, LaBranche C, Montefiori D, Samal S. Mucosal Immunization with Newcastle Disease Virus Vector Coexpressing HIV-1 Env and Gag Proteins Elicits Potent Serum, Mucosal, and Cellular Immune Responses That Protect against Vaccinia Virus Env and Gag Challenges. MBio. 2015;6:e01005 pubmed publisher
    ..These results suggest that the use of a single NDV expressing Env and Gag proteins simultaneously is a novel strategy to develop a safe and effective vaccine against HIV. ..
  5. Khattar S, DeVico A, LaBranche C, Panda A, Montefiori D, Samal S. Enhanced Immune Responses to HIV-1 Envelope Elicited by a Vaccine Regimen Consisting of Priming with Newcastle Disease Virus Expressing HIV gp160 and Boosting with gp120 and SOSIP gp140 Proteins. J Virol. 2016;90:1682-6 pubmed publisher
    ..Additionally, these responses were higher after the gp120 than after the SOSIP gp140 protein boost. ..
  6. Kanabagatte Basavarajappa M, Song H, Lamichhane C, Samal S. Glycoprotein-based enzyme-linked immunosorbent assays for serodiagnosis of infectious laryngotracheitis. J Clin Microbiol. 2015;53:1727-30 pubmed publisher
    ..Furthermore, the D-ELISA was efficient in detecting seroconversion with vectored vaccine, using recombinant Newcastle disease virus (rNDV) expressing glycoprotein D (gD) as the vaccine vector. ..
  7. Kim S, Chen S, Jiang X, Green K, Samal S. Immunogenicity of Newcastle disease virus vectors expressing Norwalk virus capsid protein in the presence or absence of VP2 protein. Virology. 2015;484:163-9 pubmed publisher
    ..These results indicate that Newcastle disease virus has great potential for developing a live Norwalk virus vaccine by inducing humoral, cellular and mucosal immune responses in humans. ..
  8. Xiao S, Khattar S, Subbiah M, Collins P, Samal S. Mutation of the f-protein cleavage site of avian paramyxovirus type 7 results in furin cleavage, fusion promotion, and increased replication in vitro but not increased replication, tissue tropism, or virulence in chickens. J Virol. 2012;86:3828-38 pubmed publisher
    ..Thus, the acquisition of furin cleavability by APMV-7 resulted in syncytium formation and increased virus yield in vitro but did not alter virus yield, tropism, or virulence in chickens. ..
  9. Kim S, Paldurai A, Samal S. A novel chimeric Newcastle disease virus vectored vaccine against highly pathogenic avian influenza virus. Virology. 2017;503:31-36 pubmed publisher

More Information


  1. Abozeid H, Paldurai A, Khattar S, Afifi M, el Kady M, El Deeb A, et al. Complete genome sequences of two avian infectious bronchitis viruses isolated in Egypt: Evidence for genetic drift and genetic recombination in the circulating viruses. Infect Genet Evol. 2017;53:7-14 pubmed publisher
    ..These results indicate the continuing evolution of IBV field strains by genetic drift and by genetic recombination leading to outbreaks in the vaccinated chicken populations in Egypt. ..
  2. Huang Z, Elankumaran S, Yunus A, Samal S. A recombinant Newcastle disease virus (NDV) expressing VP2 protein of infectious bursal disease virus (IBDV) protects against NDV and IBDV. J Virol. 2004;78:10054-63 pubmed
    ..These results indicate that the recombinant NDV can be used as a vaccine vector for other avian pathogens...
  3. Yan Y, Samal S. Role of intergenic sequences in newcastle disease virus RNA transcription and pathogenesis. J Virol. 2008;82:1323-31 pubmed
    ..The level of attenuation increased as the length of the IGS increased. Interestingly, decreased IGS length also attenuated the viruses. These findings can have significant applications in NDV vaccine development...
  4. Samuel A, Paldurai A, Kumar S, Collins P, Samal S. Complete genome sequence of avian paramyxovirus (APMV) serotype 5 completes the analysis of nine APMV serotypes and reveals the longest APMV genome. PLoS ONE. 2010;5:e9269 pubmed publisher
    ..The availability of sequence information for all known APMV serotypes will facilitate studies in epidemiology and vaccinology...
  5. Kim S, Samal S. Newcastle Disease Virus as a Vaccine Vector for Development of Human and Veterinary Vaccines. Viruses. 2016;8: pubmed publisher
    ..Therefore, NDV is an attractive vaccine vector for human pathogens for which vaccines are currently not available. NDV is also an attractive vaccine vector for animal pathogens. ..