JOSEPH NEARY

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. ncbi request reprint P2Y2 nucleotide receptors inhibit trauma-induced death of astrocytic cells
    Michelle Burgos
    Department of Biochemistry, Medical Sciences Campus, University of Puerto Rico, San Juan, Puerto Rico
    J Neurochem 103:1785-800. 2007
  2. ncbi request reprint Trophic actions of extracellular ATP: gene expression profiling by DNA array analysis
    J T Neary
    Research Service, VA Medical Center, and Departments of Pathology and Biochemistry and Molecular Biology, University of Miami School of Medicine, Miami, FL 33125, USA
    J Auton Nerv Syst 81:200-4. 2000
  3. pmc Opposing effects of P2X(7) and P2Y purine/pyrimidine-preferring receptors on proliferation of astrocytes induced by fibroblast growth factor-2: implications for CNS development, injury, and repair
    Joseph T Neary
    Research Service, Miami VA Healthcare System, Department of Pathology, University of Miami Miller School of Medicine, Miami, FL 33125, USA
    J Neurosci Res 86:3096-105. 2008
  4. pmc Cell cycle regulation of astrocytes by extracellular nucleotides and fibroblast growth factor-2
    Joseph T Neary
    Research Service, Miami VA Medical Center, Departments of Pathology and Biochemistry and Molecular Biology, and Neuroscience Program, University of Miami School of Medicine, Miami, Florida, USA
    Purinergic Signal 1:329-36. 2005
  5. ncbi request reprint Protein kinase signaling cascades in CNS trauma
    Joseph T Neary
    Research Service, Miami VA Medical Center, Florida 33125, USA
    IUBMB Life 57:711-8. 2005
  6. ncbi request reprint Signaling from P2 nucleotide receptors to protein kinase cascades induced by CNS injury: implications for reactive gliosis and neurodegeneration
    Joseph T Neary
    Research Service, VA Medical Center, Department of Pathology, University of Miami School of Medicine, Miami, FL, USA
    Mol Neurobiol 31:95-103. 2005
  7. ncbi request reprint Signaling from nucleotide receptors to protein kinase cascades in astrocytes
    Joseph T Neary
    Research Service, Miami VA Medical Center, Department of Pathology, University of Miami School of Medicine, Miami, FL 33125, USA
    Neurochem Res 29:2037-42. 2004
  8. ncbi request reprint Activation of extracellular signal-regulated kinase by stretch-induced injury in astrocytes involves extracellular ATP and P2 purinergic receptors
    Joseph T Neary
    Research Service, Veterans Affairs Medical Center, Department of Pathology, University of Miami School of Medicine, Miami, Florida 33125, USA
    J Neurosci 23:2348-56. 2003
  9. ncbi request reprint Biochemical mechanisms of action of Hypericum LI 160 in glial and neuronal cells: inhibition of neurotransmitter uptake and stimulation of extracellular signal regulated protein kinase
    J T Neary
    Miami VA Medical Center, and Department of Pathology, University of Miami School of Medicine, Florida, USA
    Pharmacopsychiatry 34:S103-7. 2001
  10. ncbi request reprint Traumatic injury activates protein kinase B/Akt in cultured astrocytes: role of extracellular ATP and P2 purinergic receptors
    Joseph T Neary
    Research Service, VA Medical Center, Departments of Pathology, Biochemistry and Molecular Biology and Neuroscience Program, University of Miami School of Medicine, Miami, Florida
    J Neurotrauma 22:491-500. 2005

Research Grants

  1. Regulation of Gliosis by Purinergic Receptor Signaling
    W Dalton Dietrich; Fiscal Year: 2006

Collaborators

Detail Information

Publications23

  1. ncbi request reprint P2Y2 nucleotide receptors inhibit trauma-induced death of astrocytic cells
    Michelle Burgos
    Department of Biochemistry, Medical Sciences Campus, University of Puerto Rico, San Juan, Puerto Rico
    J Neurochem 103:1785-800. 2007
    ..Taken together, our results demonstrate a novel role for P2Y(2) nucleotide receptors and extracellular nucleotides in mediating survival responses to glial cells undergoing cellular death induced by trauma...
  2. ncbi request reprint Trophic actions of extracellular ATP: gene expression profiling by DNA array analysis
    J T Neary
    Research Service, VA Medical Center, and Departments of Pathology and Biochemistry and Molecular Biology, University of Miami School of Medicine, Miami, FL 33125, USA
    J Auton Nerv Syst 81:200-4. 2000
    ....
  3. pmc Opposing effects of P2X(7) and P2Y purine/pyrimidine-preferring receptors on proliferation of astrocytes induced by fibroblast growth factor-2: implications for CNS development, injury, and repair
    Joseph T Neary
    Research Service, Miami VA Healthcare System, Department of Pathology, University of Miami Miller School of Medicine, Miami, FL 33125, USA
    J Neurosci Res 86:3096-105. 2008
    ..These trophic actions of P2X(7) and P2Y purine/pyrimidine receptors may contribute to the regulation of CNS development, adult neurogenesis, and the response of astrocytes to injury...
  4. pmc Cell cycle regulation of astrocytes by extracellular nucleotides and fibroblast growth factor-2
    Joseph T Neary
    Research Service, Miami VA Medical Center, Departments of Pathology and Biochemistry and Molecular Biology, and Neuroscience Program, University of Miami School of Medicine, Miami, Florida, USA
    Purinergic Signal 1:329-36. 2005
    ..Interactions between P2Y, P2X and polypeptide growth factor signaling pathways may have important implications for CNS development as well as injury and repair...
  5. ncbi request reprint Protein kinase signaling cascades in CNS trauma
    Joseph T Neary
    Research Service, Miami VA Medical Center, Florida 33125, USA
    IUBMB Life 57:711-8. 2005
    ....
  6. ncbi request reprint Signaling from P2 nucleotide receptors to protein kinase cascades induced by CNS injury: implications for reactive gliosis and neurodegeneration
    Joseph T Neary
    Research Service, VA Medical Center, Department of Pathology, University of Miami School of Medicine, Miami, FL, USA
    Mol Neurobiol 31:95-103. 2005
    ..We suggest that P2 receptor/protein kinase signaling pathways might provide novel therapeutic targets to regulate the formation of reactive astrocytes and the production of molecules that affect axonal regeneration and neurodegeneration...
  7. ncbi request reprint Signaling from nucleotide receptors to protein kinase cascades in astrocytes
    Joseph T Neary
    Research Service, Miami VA Medical Center, Department of Pathology, University of Miami School of Medicine, Miami, FL 33125, USA
    Neurochem Res 29:2037-42. 2004
    ....
  8. ncbi request reprint Activation of extracellular signal-regulated kinase by stretch-induced injury in astrocytes involves extracellular ATP and P2 purinergic receptors
    Joseph T Neary
    Research Service, Veterans Affairs Medical Center, Department of Pathology, University of Miami School of Medicine, Miami, Florida 33125, USA
    J Neurosci 23:2348-56. 2003
    ....
  9. ncbi request reprint Biochemical mechanisms of action of Hypericum LI 160 in glial and neuronal cells: inhibition of neurotransmitter uptake and stimulation of extracellular signal regulated protein kinase
    J T Neary
    Miami VA Medical Center, and Department of Pathology, University of Miami School of Medicine, Florida, USA
    Pharmacopsychiatry 34:S103-7. 2001
    ..Taken together, our findings suggest that Hypericum LI 160 can affect rapidly-acting as well as slower-developing, long-term biochemical mechanisms related to depressive disorders...
  10. ncbi request reprint Traumatic injury activates protein kinase B/Akt in cultured astrocytes: role of extracellular ATP and P2 purinergic receptors
    Joseph T Neary
    Research Service, VA Medical Center, Departments of Pathology, Biochemistry and Molecular Biology and Neuroscience Program, University of Miami School of Medicine, Miami, Florida
    J Neurotrauma 22:491-500. 2005
    ..This suggests that P2 receptor/Akt signaling promotes astrocyte survival and growth, and this process may play a role in the generation of reactive gliosis after TBI...
  11. ncbi request reprint P2 receptor signalling, proliferation of astrocytes, and expression of molecules involved in cell-cell interactions
    Joseph T Neary
    Research Service, Miami VA Medical Center, FL 33125, USA
    Novartis Found Symp 276:131-43; discussion 143-7, 233-7, 275-81. 2006
    ..These findings support the hypothesis that purinergic signalling via protein kinase cascades plays a key role in astrocyte proliferation, glia-glia connections, and neuron-glia interactions in both normal and pathological conditions...
  12. pmc Purinergic signaling induces thrombospondin-1 expression in astrocytes
    Minh D Tran
    Research Service, Miami Veterans Affairs Medical Center, Miami, FL 33125, USA
    Proc Natl Acad Sci U S A 103:9321-6. 2006
    ....
  13. pmc A new in vitro model of the glial scar inhibits axon growth
    Ina B Wanner
    Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, USA
    Glia 56:1691-709. 2008
    ..c) 2008 Wiley-Liss, Inc...
  14. doi request reprint Purinergic receptor signaling regulates N-cadherin expression in primary astrocyte cultures
    Minh D Tran
    Research Service, Miami VA Medical Center, Department of Pathology, The Neuroscience Program, University of Miami Miller School of Medicine, Miami, Florida, USA
    J Neurochem 105:272-86. 2008
    ..The findings presented here demonstrate a role for extracellular ATP, purinergic receptors and protein kinase signaling in regulating N-cadherin expression and suggest a role for this mechanism in cell-cell interactions...
  15. ncbi request reprint P2 purinergic receptors signal to glycogen synthase kinase-3beta in astrocytes
    Joseph T Neary
    Research Service, Miami VA Healthcare System, Miami, Florida
    J Neurosci Res 84:515-24. 2006
    ..These findings suggest that purinergic signaling contributes to the regulation of GSK3beta functions, one of which may be the response of astrocytes to CNS injury on release of ATP...
  16. ncbi request reprint Bi-functional effects of ATP/P2 receptor activation on tumor necrosis factor-alpha release in lipopolysaccharide-stimulated astrocytes
    Brandon M Kucher
    Research Service, Miami Veterans Affairs Medical Center, 1201 NW 16th Street, Miami, FL 33125, USA
    J Neurochem 92:525-35. 2005
    ....
  17. doi request reprint Trophic functions of nucleotides in the central nervous system
    Joseph T Neary
    Department of Pathology, Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33125, USA
    Trends Neurosci 32:189-98. 2009
    ..Here, we illuminate the contribution of extracellular nucleotides to the development, growth, cellular plasticity and death of neural cells and the mechanisms regulating these trophic effects...
  18. ncbi request reprint Induction of COX-2 and reactive gliosis by P2Y receptors in rat cortical astrocytes is dependent on ERK1/2 but independent of calcium signalling
    Roberta Brambilla
    Department of Pharmacological Sciences, University of Milan School of Pharmacy, Milan, Italy
    J Neurochem 83:1285-96. 2002
    ..Based on the involvement of cyclooxygenase-2 and inflammation in neurodegenerative diseases, these findings open up new avenues in the identification of novel biological targets for the pharmacological manipulation of neurodegeneration...
  19. ncbi request reprint Mechanisms of P2X7 receptor-mediated ERK1/2 phosphorylation in human astrocytoma cells
    Fernand Pierre Gendron
    Department of Biochemistry, University of Missouri Columbia, Columbia, Missouri 65212, USA
    Am J Physiol Cell Physiol 284:C571-81. 2003
    ..These results support the hypothesis that the P2X(7) receptor and its signaling pathways play a role in astrocyte-mediated inflammation and neurodegenerative disease...
  20. ncbi request reprint P2Y receptors activate neuroprotective mechanisms in astrocytic cells
    Nataliya E Chorna
    Department of Chemistry, Rio Piedras Campus, University of Puerto Rico, San Juan, Puerto Rico
    J Neurochem 91:119-32. 2004
    ..Taken together, our results suggest an important novel role for the P2Y2 receptor in survival and neuroprotective mechanisms under pathological conditions...
  21. pmc P2X7 receptors stimulate AKT phosphorylation in astrocytes
    Maria C Jacques-Silva
    Departamento de Bioquimica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Br J Pharmacol 141:1106-17. 2004
    ....
  22. ncbi request reprint P2X(7) receptors: properties and relevance to CNS function
    Shumin Duan
    Institute of Neuroscience and Key Laboratory of Neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Glia 54:738-46. 2006
    ....
  23. pmc ATP regulates the differentiation of mammalian skeletal muscle by activation of a P2X5 receptor on satellite cells
    Mina Ryten
    Autonomic Neuroscience Institute, Royal Free and University College Medical School, Royal Free Campus, Rowland Hill Street, London NW3 2PF, U K
    J Cell Biol 158:345-55. 2002
    ..These results not only demonstrate the existence of a novel regulator of skeletal muscle differentiation, namely ATP, but also a new role for ionotropic P2X receptors in the control of cell fate...

Research Grants1

  1. Regulation of Gliosis by Purinergic Receptor Signaling
    W Dalton Dietrich; Fiscal Year: 2006
    ..Thus, important advances in the understanding of the mechanisms underlying gliosis may provide new approaches to restore deficits in motor skills and cognitive functions caused by brain injury. [unreadable] [unreadable]..