M Natarajan

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. ncbi request reprint NF-kappaB DNA-binding activity after high peak power pulsed microwave (8.2 GHz) exposure of normal human monocytes
    Mohan Natarajan
    Department of Radiation Oncology and Center for Environmental Radiation Toxicology, The University of Texas Health Science Center, San Antonio 78229 3900, USA
    Bioelectromagnetics 23:271-7. 2002
  2. pmc Irreversible EGFR inhibitor EKB-569 targets low-LET γ-radiation-triggered rel orchestration and potentiates cell death in squamous cell carcinoma
    Natarajan Aravindan
    Department of Otolaryngology, Head and Neck Surgery, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
    PLoS ONE 6:e29705. 2011
  3. pmc Molecular basis of 'hypoxic' breast cancer cell radio-sensitization: phytochemicals converge on radiation induced Rel signaling
    Sheeja Aravindan
    Department of Radiation Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    Radiat Oncol 8:46. 2013
  4. ncbi request reprint Effect of melatonin on cell growth, metabolic activity, and cell cycle distribution
    M Natarajan
    Department of Radiation Oncology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Pineal Res 31:228-33. 2001
  5. doi request reprint Induced telomerase activity in primary aortic endothelial cells by low-LET gamma-radiation is mediated through NF-kappaB activation
    M Natarajan
    Department of Radiation Oncology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Br J Radiol 81:711-20. 2008
  6. ncbi request reprint Oxidative stress signalling: a potential mediator of tumour necrosis factor alpha-induced genomic instability in primary vascular endothelial cells
    M Natarajan
    Department of Radiation Oncology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Br J Radiol 80:S13-22. 2007
  7. ncbi request reprint Post-translational modification of I-kappa B alpha activates NF-kappa B in human monocytes exposed to 56Fe ions
    Mohan Natarajan
    Department of Radiation Oncology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Radiat Environ Biophys 41:139-44. 2002
  8. ncbi request reprint Nuclear translocation and DNA-binding activity of NFKB (NF-kappaB) after exposure of human monocytes to pulsed ultra-wideband electromagnetic fields (1 kV/cm) fails to transactivate kappaB-dependent gene expression
    M Natarajan
    Department of Radiation Oncology, University of Texas Health Science Center, Brooks City Base, San Antonio, TX 78229 3900, USA
    Radiat Res 165:645-54. 2006
  9. doi request reprint Nitric oxide-mediated inhibition of NFkappaB regulates hyperthermia-induced apoptosis
    Natarajan Aravindan
    Department of Radiation Oncology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Cell Biochem 106:999-1009. 2009
  10. ncbi request reprint Potential use of drug carried-liposomes for cancer therapy via direct intratumoral injection
    Ande Bao
    Department of Otolaryngology Head and Neck Surgery, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Int J Pharm 316:162-9. 2006

Research Grants

Detail Information

Publications24

  1. ncbi request reprint NF-kappaB DNA-binding activity after high peak power pulsed microwave (8.2 GHz) exposure of normal human monocytes
    Mohan Natarajan
    Department of Radiation Oncology and Center for Environmental Radiation Toxicology, The University of Texas Health Science Center, San Antonio 78229 3900, USA
    Bioelectromagnetics 23:271-7. 2002
    ..Because of the broad distribution of SAR's in the flask, experiments need to be performed to determine if the changes observed are associated with cells exposed to high or low SARs...
  2. pmc Irreversible EGFR inhibitor EKB-569 targets low-LET γ-radiation-triggered rel orchestration and potentiates cell death in squamous cell carcinoma
    Natarajan Aravindan
    Department of Otolaryngology, Head and Neck Surgery, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
    PLoS ONE 6:e29705. 2011
    ..Further pre-clinical in-vivo studies are warranted...
  3. pmc Molecular basis of 'hypoxic' breast cancer cell radio-sensitization: phytochemicals converge on radiation induced Rel signaling
    Sheeja Aravindan
    Department of Radiation Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    Radiat Oncol 8:46. 2013
    ..About 50% of locally advanced BCa, where radiotherapy is less effective are suggested to be due to hypoxic regions. In this study, we investigated the potential of bioactive phytochemicals in radio-sensitizing hypoxic BCa cells...
  4. ncbi request reprint Effect of melatonin on cell growth, metabolic activity, and cell cycle distribution
    M Natarajan
    Department of Radiation Oncology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Pineal Res 31:228-33. 2001
    ..Exogenously added melatonin appeared to have a limited influence on the normal functioning of the cells even when the exposure continued for 72 hr...
  5. doi request reprint Induced telomerase activity in primary aortic endothelial cells by low-LET gamma-radiation is mediated through NF-kappaB activation
    M Natarajan
    Department of Radiation Oncology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Br J Radiol 81:711-20. 2008
    ..These findings indicate that NF-kappaB activation following ionizing radiation exposure may elicit a survival advantage by upregulating and maintaining telomerase activity...
  6. ncbi request reprint Oxidative stress signalling: a potential mediator of tumour necrosis factor alpha-induced genomic instability in primary vascular endothelial cells
    M Natarajan
    Department of Radiation Oncology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Br J Radiol 80:S13-22. 2007
    ....
  7. ncbi request reprint Post-translational modification of I-kappa B alpha activates NF-kappa B in human monocytes exposed to 56Fe ions
    Mohan Natarajan
    Department of Radiation Oncology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Radiat Environ Biophys 41:139-44. 2002
    ....
  8. ncbi request reprint Nuclear translocation and DNA-binding activity of NFKB (NF-kappaB) after exposure of human monocytes to pulsed ultra-wideband electromagnetic fields (1 kV/cm) fails to transactivate kappaB-dependent gene expression
    M Natarajan
    Department of Radiation Oncology, University of Texas Health Science Center, Brooks City Base, San Antonio, TX 78229 3900, USA
    Radiat Res 165:645-54. 2006
    ..From these results, it is clear that the EMF-induced NFKB activation is only a transient response, with minimal or no downstream effect...
  9. doi request reprint Nitric oxide-mediated inhibition of NFkappaB regulates hyperthermia-induced apoptosis
    Natarajan Aravindan
    Department of Radiation Oncology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Cell Biochem 106:999-1009. 2009
    ..Similarly, over-expression of NFkappaB by transient transfection inhibits heat-induced apoptosis. These results demonstrate that apoptosis upon hyperthermia exposure of MCF-7 cells is regulated by NO-mediated suppression of NFkappaB...
  10. ncbi request reprint Potential use of drug carried-liposomes for cancer therapy via direct intratumoral injection
    Ande Bao
    Department of Otolaryngology Head and Neck Surgery, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Int J Pharm 316:162-9. 2006
    ..Higher intratumoral retention of 99mTc-liposomes accompanied by an improved intratumoral diffusion suggests that intratumorally administered liposomal drugs are potentially promising agents for solid tumor local therapy...
  11. ncbi request reprint High glucose induced NF-kappaB DNA-binding activity in HAEC is maintained under low shear stress but inhibited under high shear stress: role of nitric oxide
    Sumathy Mohan
    Department of Pathology, The University of Texas Health Science Center, San Antonio, TX 78229, USA
    Atherosclerosis 171:225-34. 2003
    ..These observations explain, in part, the mechanism by means of which hyperglycemia accelerates the focal development of atherosclerotic lesions in low shear (lesion prone) areas of the arterial tree...
  12. ncbi request reprint IkappaBalpha-dependent regulation of low-shear flow-induced NF-kappa B activity: role of nitric oxide
    Sumathy Mohan
    Department of Pathology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Am J Physiol Cell Physiol 284:C1039-47. 2003
    ....
  13. ncbi request reprint Setup and characterization of a human head and neck squamous cell carcinoma xenograft model in nude rats
    Ande Bao
    Department of Otolaryngology Head and Neck Surgery, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Otolaryngol Head Neck Surg 135:853-7. 2006
    ..To develop and characterize a new head and neck cancer animal model...
  14. pmc High glucose-induced IKK-Hsp-90 interaction contributes to endothelial dysfunction
    Sumathy Mohan
    Department of Pathology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Am J Physiol Cell Physiol 296:C182-92. 2009
    ..These results illuminate a possible mechanism for the declining eNOS activity reported under conditions of HG...
  15. doi request reprint Diabetic eNOS knockout mice develop distinct macro- and microvascular complications
    Sumathy Mohan
    Department of Pathology, The University of Texas Health Science Center, San Antonio, TX 78229, USA
    Lab Invest 88:515-28. 2008
    ..The DKO model may suggest novel therapeutic strategies to prevent both vascular and renal complications of diabetes...
  16. ncbi request reprint Curcumin-altered p53-response genes regulate radiosensitivity in p53-mutant Ewing's sarcoma cells
    J Veeraraghavan
    Department of Radiation Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Anticancer Res 30:4007-15. 2010
    ..Herein, we investigated the radiosensitizing effect of curcumin in p53 mutant Ewing's sarcoma (ES) cells...
  17. doi request reprint Abscopal effect of low-LET γ-radiation mediated through Rel protein signal transduction in a mouse model of nontargeted radiation response
    S Aravindan
    Department of Radiation Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    Cancer Gene Ther 21:54-9. 2014
    ..More importantly, the results imply that orchestration of NF-κB signal transduction in nontargeted tissues may serve as an effector and could play a key role in induced abscopal responses...
  18. ncbi request reprint Protection against oxidative protein damage induced by metal-catalyzed reaction or alkylperoxyl radicals: comparative effects of melatonin and other antioxidants
    J C Mayo
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, 78229 3900, USA
    Biochim Biophys Acta 1620:139-50. 2003
    ..On the other hand, the relative protective efficiency in the AAPH model was melatonin approximately trolox>GSH>ascorbate...
  19. ncbi request reprint Alteration of apoptotic signaling molecules as a function of time after radiation in human neuroblastoma cells
    Natarajan Aravindan
    OUPB 1430, Department of Radiation Oncology, College of Medicine, University of Oklahoma Health Sciences Center, 825 North East 10th Street, Oklahoma City, OK 73104, USA
    Mol Cell Biochem 310:167-79. 2008
    ..These results suggest that the time-dependent regulation of apoptotic response may determine the relationship between the level of spontaneous apoptosis in cells and their radiosensitivity...
  20. ncbi request reprint NFkappaB activity and transcriptional responses in human breast adenocarcinoma cells after single and fractionated irradiation
    Rakhesh Madhusoodhanan
    Department of Radiation Oncology, The University of Oklahoma Health Sciences Center, 825 NE 10th Street, Oklahoma City, OK 73104, USA
    Cancer Biol Ther 8:765-73. 2009
    ..The results of the study clearly show distinct differences in the molecular response of cells between SDR and FIR exposures. We identified several potential targets that may affect radio-resistance following FIR...
  21. doi request reprint Hyperthermia induced NFkappaB mediated apoptosis in normal human monocytes
    Natarajan Aravindan
    Department of Radiation Oncology, OUPB 1430, University of Oklahoma Health Sciences Center, 825 N E 10th Street, Oklahoma City, OK 73104, USA
    Mol Cell Biochem 327:29-37. 2009
    ..Similarly, RPA analysis showed that HT persistently inhibits NFkappaB mRNA. These results demonstrate that apoptosis upon HT exposure of MM6 cells is regulated by IkappaBalpha phosphorylation mediated suppression of NFkappaB...
  22. ncbi request reprint Antioxidant activity of melatonin in Chinese hamster ovarian cells: changes in cellular proliferation and differentiation
    Rosa M Sainz
    Department of Cellular and Structural Biology, Mail Code 7762, University of Texas Health Science Center, San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Biochem Biophys Res Commun 302:625-34. 2003
    ..We conclude that the cellular redox state may be involved in cellular transformation caused by antioxidants such as melatonin and trolox...
  23. ncbi request reprint High glucose induced nuclear factor kappa B mediated inhibition of endothelial cell migration
    Masao Hamuro
    Department of Pathology, University of Texas Health Science Center at San Antonio, 78229, USA
    Atherosclerosis 162:277-87. 2002
    ....
  24. ncbi request reprint Fenoldopam inhibits nuclear translocation of nuclear factor kappa B in a rat model of surgical ischemic acute renal failure
    Natarajan Aravindan
    Division of Anesthesiology and Critical Care, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Cardiothorac Vasc Anesth 20:179-86. 2006
    ..The authors used a rat model of surgical acute ischemic nephropathy to test the hypothesis that fenoldopam attenuates ischemia/reperfusion (I/R)-induced NF-kappaB-mediated inflammation...

Research Grants1

  1. ENHANCED APOPTOSIS BY TARGETING PROTEIN REDOX STATUS
    Mohan Natarajan; Fiscal Year: 2009
    ..abstract_text> ..