P Micevych

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Membrane-initiated estradiol signaling regulating sexual receptivity
    Paul E Micevych
    Laboratory of Neuroendocrinology, Department of Neurobiology, Brain Research Institute, David Geffen School of Medicine at University of California Los Angeles Los Angeles, CA, USA
    Front Endocrinol (Lausanne) 2:26. 2011
  2. pmc The Neurosteroid Progesterone Underlies Estrogen Positive Feedback of the LH Surge
    Paul Micevych
    Laboratory of Neuroendocrinology, Department of Neurobiology, David Geffen School of Medicine, Brain Research Institute, University of California Los Angeles, CA, USA
    Front Endocrinol (Lausanne) 2:90. 2011
  3. pmc Membrane-initiated estradiol actions mediate structural plasticity and reproduction
    Paul Micevych
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1763, United States
    Front Neuroendocrinol 33:331-41. 2012
  4. pmc CAV1 siRNA reduces membrane estrogen receptor-α levels and attenuates sexual receptivity
    Amy Christensen
    Department of Neurobiology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095 1763, USA
    Endocrinology 153:3872-7. 2012
  5. pmc Membrane estrogen receptors acting through metabotropic glutamate receptors: an emerging mechanism of estrogen action in brain
    Paul E Micevych
    Department of Neurobiology and Laboratory of Neuroendocrinology of the Brain Research Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Mol Neurobiol 38:66-77. 2008
  6. pmc Sex differences in hypothalamic astrocyte response to estradiol stimulation
    John Kuo
    Department of Neurobiology, Laboratory of Neuroendocrinology of the Brain Research Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Biol Sex Differ 1:7. 2010
  7. ncbi request reprint Estradiol stimulates progesterone synthesis in hypothalamic astrocyte cultures
    Paul E Micevych
    Department of Neurobiology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095 1763, USA
    Endocrinology 148:782-9. 2007
  8. pmc Neuroprogesterone: key to estrogen positive feedback?
    Paul Micevych
    Department of Neurobiology, David Geffen School of Medicine, Laboratory of Neuroendocrinology, Brain Research Institute at UCLA, Los Angeles, CA 90095 1763, USA
    Brain Res Rev 57:470-80. 2008
  9. pmc Synthesis and function of hypothalamic neuroprogesterone in reproduction
    Paul Micevych
    Department of Neurobiology, David Geffen School of Medicine, Brain Research Institute at University of California Los Angeles, Los Angeles, California 90095 1763, USA
    Endocrinology 149:2739-42. 2008
  10. pmc Membrane estrogen receptor-alpha interacts with metabotropic glutamate receptor type 1a to mobilize intracellular calcium in hypothalamic astrocytes
    John Kuo
    Department of Neurobiology, David Geffen School of Medicine at University of California, Los Angeles, 10833 LeConte Avenue, 73 078 CHS, Los Angeles, California 90095 1763
    Endocrinology 150:1369-76. 2009

Research Grants

  1. NEUROPEPTIDE-STEROID INTERACTIONS IN THE CNS
    Paul Micevych; Fiscal Year: 2003

Collaborators

Detail Information

Publications30

  1. pmc Membrane-initiated estradiol signaling regulating sexual receptivity
    Paul E Micevych
    Laboratory of Neuroendocrinology, Department of Neurobiology, Brain Research Institute, David Geffen School of Medicine at University of California Los Angeles Los Angeles, CA, USA
    Front Endocrinol (Lausanne) 2:26. 2011
    ....
  2. pmc The Neurosteroid Progesterone Underlies Estrogen Positive Feedback of the LH Surge
    Paul Micevych
    Laboratory of Neuroendocrinology, Department of Neurobiology, David Geffen School of Medicine, Brain Research Institute, University of California Los Angeles, CA, USA
    Front Endocrinol (Lausanne) 2:90. 2011
    ..This differential responsiveness is part of the timing mechanism triggering the LH surge...
  3. pmc Membrane-initiated estradiol actions mediate structural plasticity and reproduction
    Paul Micevych
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1763, United States
    Front Neuroendocrinol 33:331-41. 2012
    ....
  4. pmc CAV1 siRNA reduces membrane estrogen receptor-α levels and attenuates sexual receptivity
    Amy Christensen
    Department of Neurobiology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095 1763, USA
    Endocrinology 153:3872-7. 2012
    ..Thus, CAV1-mediated ERα trafficking to the cell membrane is required for estradiol activation of circuits underlying female sexual receptivity...
  5. pmc Membrane estrogen receptors acting through metabotropic glutamate receptors: an emerging mechanism of estrogen action in brain
    Paul E Micevych
    Department of Neurobiology and Laboratory of Neuroendocrinology of the Brain Research Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Mol Neurobiol 38:66-77. 2008
    ....
  6. pmc Sex differences in hypothalamic astrocyte response to estradiol stimulation
    John Kuo
    Department of Neurobiology, Laboratory of Neuroendocrinology of the Brain Research Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Biol Sex Differ 1:7. 2010
    ..To determine whether hypothalamic astrocytes are sexually differentiated, we examined the cellular responses of female and male astrocytes to estradiol stimulation...
  7. ncbi request reprint Estradiol stimulates progesterone synthesis in hypothalamic astrocyte cultures
    Paul E Micevych
    Department of Neurobiology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095 1763, USA
    Endocrinology 148:782-9. 2007
    ..The present results are consistent with our hypothesis that estrogen-positive feedback regulating the LH surge involves stimulating local progesterone synthesis by hypothalamic astrocytes...
  8. pmc Neuroprogesterone: key to estrogen positive feedback?
    Paul Micevych
    Department of Neurobiology, David Geffen School of Medicine, Laboratory of Neuroendocrinology, Brain Research Institute at UCLA, Los Angeles, CA 90095 1763, USA
    Brain Res Rev 57:470-80. 2008
    ..This neuroprogesterone also facilitated proceptive behavior. Blocking either progesterone synthesis or progesterone receptor in estrogen-primed ovx/adx prevented proceptive but not receptive behaviors...
  9. pmc Synthesis and function of hypothalamic neuroprogesterone in reproduction
    Paul Micevych
    Department of Neurobiology, David Geffen School of Medicine, Brain Research Institute at University of California Los Angeles, Los Angeles, California 90095 1763, USA
    Endocrinology 149:2739-42. 2008
    ..The newly synthesized neuroprogesterone acts on estradiol-induced progesterone receptors in nearby neurons to initiate the LH surge...
  10. pmc Membrane estrogen receptor-alpha interacts with metabotropic glutamate receptor type 1a to mobilize intracellular calcium in hypothalamic astrocytes
    John Kuo
    Department of Neurobiology, David Geffen School of Medicine at University of California, Los Angeles, 10833 LeConte Avenue, 73 078 CHS, Los Angeles, California 90095 1763
    Endocrinology 150:1369-76. 2009
    ..These results indicate that mERalpha acts through mGluR1a, and mGluR1a activation facilitates the estradiol response, suggesting that neural activity can modify estradiol-induced membrane signaling in astrocytes...
  11. pmc Membrane estradiol signaling in the brain
    Paul Micevych
    Department of Neurobiology and the Laboratory of Neuroendocrinology David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1763, USA
    Front Neuroendocrinol 30:315-27. 2009
    ....
  12. pmc Physiology of membrane oestrogen receptor signalling in reproduction
    P Micevych
    Department of Neurobiology, Laboratory of Neuroendocrinology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    J Neuroendocrinol 21:249-56. 2009
    ..The ERalpha-mGluR1a interaction is necessary for critical calcium flux. These two examples provide support for the hypothesis that membrane ERs are not themselves G-protein receptors; rather, they use mGluRs to signal...
  13. ncbi request reprint The luteinizing hormone surge is preceded by an estrogen-induced increase of hypothalamic progesterone in ovariectomized and adrenalectomized rats
    Paul Micevych
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Laboratory of Neuroendocrinology, Brain Research Institute, University of California, Los Angeles, Calif, USA
    Neuroendocrinology 78:29-35. 2003
    ..Together, these data strongly suggest that estrogen enhances neuroprogesterone synthesis in the hypothalamus that is involved in the positive feedback regulating the LH surge...
  14. ncbi request reprint Oestrogen modulates cholecystokinin: opioid interactions in the nervous system
    Paul Micevych
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Laboratory of Neuroendocrinology of the Brain Research Institute, UCLA, Los Angeles, CA 90095 1763, USA
    Pharmacol Toxicol 91:387-97. 2002
    ..In this paper we present new data and review previous work that demonstrates oestrogen modulation of functional CCK-opioid interactions that regulate reproductive behaviour, cortical function and nociception...
  15. ncbi request reprint Estrogen receptor-alpha is required for estrogen-induced mu-opioid receptor internalization
    Paul E Micevych
    Laboratory of Neuroendocrinology of the Brain Research Institute, Department of Neurobiology, Mental Retardation Research Center, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Neurosci Res 71:802-10. 2003
    ..The results of the present experiments indicate that ERalpha is required for estrogen-induced MOR internalization and suggest that ERalpha can mediate rapid actions of estrogen...
  16. ncbi request reprint Estrogen and endogenous opioids regulate CCK in reproductive circuits
    P Micevych
    Department of Neurobiology, Mental Retardation Research Center, UCLA School of Medicine, Box 951763, Los Angeles, CA 90095, USA
    Peptides 22:1235-44. 2001
    ..Recent studies demonstrate an estrogen-dependent interaction between endogenous opioid and CCK systems that control reproductive behavior...
  17. pmc Estradiol regulation of progesterone synthesis in the brain
    Paul Micevych
    Department of Neurobiology, David Geffen School of Medicine at ULCA, Los Angeles, CA 90095, USA
    Mol Cell Endocrinol 290:44-50. 2008
    ..Thus, it is a cooperative action of astrocytes and neurons that is needed for estrogen positive feedback and stimulation of the LH surge...
  18. pmc An interaction of oxytocin receptors with metabotropic glutamate receptors in hypothalamic astrocytes
    J Kuo
    Department of Neurobiology, Laboratory of Neuroendocrinology and Brain Research Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1763, USA
    J Neuroendocrinol 21:1001-6. 2009
    ..These results suggest that the OTR signals through the mGluR1a to release Ca(2+) from intracellular stores and rapid, nongenomic oestradiol stimulation does not influence OTR signalling in astrocytes...
  19. ncbi request reprint Direct regulation of adult brain function by the male-specific factor SRY
    Phoebe Dewing
    Department of Human Genetics, University of California, Los Angeles, Los Angles, California 90095, USA
    Curr Biol 16:415-20. 2006
    ..These results demonstrate a direct male-specific effect on the brain by a gene encoded only in the male genome, without any mediation by gonadal hormones...
  20. ncbi request reprint Estrogen-induced mu-opioid receptor internalization in the medial preoptic nucleus is mediated via neuropeptide Y-Y1 receptor activation in the arcuate nucleus of female rats
    Richard H Mills
    Department of Neurobiology, David Geffen School of Medicine, Laboratory of Neuroendocrinology, Brain Research Institute, University of California, Los Angeles, California 90095, USA
    J Neurosci 24:947-55. 2004
    ..These results suggest that a sequential sex steroid activation of NPY and MOR circuits regulates sexual receptivity...
  21. pmc Hormonal regulation of female reproduction
    A Christensen
    Department of Neurobiology, University of California, Los Angeles, CA 90095, USA
    Horm Metab Res 44:587-91. 2012
    ..reproductive strategies? What internal and external conditions modulate the synthesis and release of GnRH? How does GnRH modulate reproductive behavior within the hypothalamus? How does disease shift the activity of the HPG axis?..
  22. ncbi request reprint Induction of CCK mRNA levels in the limbic-hypothalamic circuit: time course and site-specific effects of estrogen
    P Micevych
    Department of Neurobiology, School of Medicine, UCLA 90095 1763, USA
    J Neurobiol 30:465-79. 1996
    ..The sitespecific induction of CCK mRNA levels within the limbic-hypothalamic nuclei provides another important facet of estrogenic modulation of CCK induction...
  23. pmc PI3 kinase/Akt activation mediates estrogen and IGF-1 nigral DA neuronal neuroprotection against a unilateral rat model of Parkinson's disease
    Arnulfo Quesada
    Department of Neurobiology, Brain Research Institute, David Geffen School of Medicine, UCLA, Los Angeles, California, USA
    Dev Neurobiol 68:632-44. 2008
    ..These findings indicate that estrogen and IGF-1-mediated SNpc DA neuronal protection is dependent on PI3K/Akt signaling, but not on the MAPK/ERK pathway...
  24. ncbi request reprint Estrogen receptor-alpha mediates estradiol attenuation of ATP-induced Ca2+ signaling in mouse dorsal root ganglion neurons
    Victor V Chaban
    Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Neurosci Res 81:31-7. 2005
    ..These results show that mouse DRG neurons express ERs and the rapid attenuation of ATP-induced [Ca2+]i signaling is mediated by membrane-associated ERalpha...
  25. ncbi request reprint Estrogen interacts with the IGF-1 system to protect nigrostriatal dopamine and maintain motoric behavior after 6-hydroxdopamine lesions
    Arnulfo Quesada
    Department of Neurobiology, Laboratory of Neuroendocrinology, Brain Research Institute, David Geffen School of Medicine UCLA, Los Angeles, California 90095 1763, USA
    J Neurosci Res 75:107-16. 2004
    ..These findings suggest that IGF-1 and estrogen acting through the IGF-1 system may be critical for neuroprotective effects of estrogen on nigrostriatal DA neurons in this model of PD...
  26. ncbi request reprint Site-specific decrease of progesterone receptor mRNA expression in the hypothalamus of middle-aged persistently estrus rats
    Richard H Mills
    Department of Neurobiology, UCLA School of Medicine, Los Angeles, CA 90095 1763, USA
    Brain Res 955:200-6. 2002
    ..In acyclic, long-term PE rats, diminished estrogen-induced expression of progesterone receptors is correlated with a previously shown inability to respond to exogenous progesterone...
  27. ncbi request reprint Site-specific estrogen and progestin regulation of orphanin FQ/nociceptin and nociceptin opioid receptor mRNA expression in the female rat limbic hypothalamic system
    Kevin Sinchak
    Department of Neurobiology, Brain Research Institute, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California 90095 1763, USA
    J Comp Neurol 496:252-68. 2006
    ..Steroid regulation of OFQ/N and NOP in the medial preoptic nucleus and VMH is consistent with emerging data indicating that this opioid system regulates female reproduction...
  28. pmc Temporal and concentration-dependent effects of oestradiol on neural pathways mediating sexual receptivity
    P Micevych
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Laboratory of Neuroendocrinology, Brain Research Institute, University of California, Los Angeles, CA, USA
    J Neuroendocrinol 25:1012-23. 2013
    ..These include the GRP30 and the STX activated Gq-mER. Finally, we report on the importance of GABA acting at GABAB receptors for oestradiol membrane signalling that regulates lordosis circuit activation and sexual receptivity. ..
  29. ncbi request reprint The superior olivary complex of the hamster has multiple periods of cholinergic neuron development
    Juman Raji-Kubba
    Physiological Science Department, UCLA, 90095, USA
    J Chem Neuroanat 24:75-93. 2002
    ..These data suggest that the lateral olivocochlear system co-expresses ChAT and calcitonin gene-related peptide, whereas the medial olivocochlear system does not...
  30. ncbi request reprint Presynaptic N-methyl-D-aspartate receptor expression is increased by estrogen in an aromatase-rich area of the songbird hippocampus
    Colin J Saldanha
    Biological Sciences, Lehigh University, Bethlehem, Pennsylvania 18015, USA
    J Comp Neurol 469:522-34. 2004
    ..NR-mediated autoreception may underlie estrogenic enhancement of HP structural and functional plasticity...

Research Grants1

  1. NEUROPEPTIDE-STEROID INTERACTIONS IN THE CNS
    Paul Micevych; Fiscal Year: 2003
    ..These experiments will not only tell us about the actions of steroids in specific circuits, but they will also provide important information about the interactions of neuropeptide circuits regulating behavior. ..