Paul McCray

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. McCray P, Pewe L, Wohlford Lenane C, Hickey M, Manzel L, Shi L, et al. Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus. J Virol. 2007;81:813-21 pubmed
    ..This model of lethal infection with SARS-CoV should be useful for studies of pathogenesis and for the development of antiviral therapies. ..
  2. Bartlett J, Meyerholz D, Wohlford Lenane C, Naumann P, Salzman N, McCray P. Increased susceptibility to otitis media in a Splunc1-deficient mouse model. Dis Model Mech. 2015;8:501-8 pubmed publisher
    ..The Splunc1(-/-) mouse model should help investigators to better understand both the biological role of Splunc1 as well as host defense mechanisms in the middle ear. ..
  3. Ramachandran S, Osterhaus S, Parekh K, Jacobi A, Behlke M, McCray P. SYVN1, NEDD8, and FBXO2 Proteins Regulate ΔF508 Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Ubiquitin-mediated Proteasomal Degradation. J Biol Chem. 2016;291:25489-25504 pubmed
    ..It suggests that SYVN1 and FBXO2 represent two distinct multiprotein complexes that may degrade ΔF508-CFTR in airway epithelia and identifies a new role for NEDD8 in regulating ΔF508-CFTR ubiquitination. ..

Detail Information

Publications3

  1. McCray P, Pewe L, Wohlford Lenane C, Hickey M, Manzel L, Shi L, et al. Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus. J Virol. 2007;81:813-21 pubmed
    ..This model of lethal infection with SARS-CoV should be useful for studies of pathogenesis and for the development of antiviral therapies. ..
  2. Bartlett J, Meyerholz D, Wohlford Lenane C, Naumann P, Salzman N, McCray P. Increased susceptibility to otitis media in a Splunc1-deficient mouse model. Dis Model Mech. 2015;8:501-8 pubmed publisher
    ..The Splunc1(-/-) mouse model should help investigators to better understand both the biological role of Splunc1 as well as host defense mechanisms in the middle ear. ..
  3. Ramachandran S, Osterhaus S, Parekh K, Jacobi A, Behlke M, McCray P. SYVN1, NEDD8, and FBXO2 Proteins Regulate ΔF508 Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Ubiquitin-mediated Proteasomal Degradation. J Biol Chem. 2016;291:25489-25504 pubmed
    ..It suggests that SYVN1 and FBXO2 represent two distinct multiprotein complexes that may degrade ΔF508-CFTR in airway epithelia and identifies a new role for NEDD8 in regulating ΔF508-CFTR ubiquitination. ..