Affiliation: University of Iowa
- McCray P, Pewe L, Wohlford Lenane C, Hickey M, Manzel L, Shi L, et al. Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus. J Virol. 2007;81:813-21 pubmed..This model of lethal infection with SARS-CoV should be useful for studies of pathogenesis and for the development of antiviral therapies. ..
- Bartlett J, Meyerholz D, Wohlford Lenane C, Naumann P, Salzman N, McCray P. Increased susceptibility to otitis media in a Splunc1-deficient mouse model. Dis Model Mech. 2015;8:501-8 pubmed publisher..The Splunc1(-/-) mouse model should help investigators to better understand both the biological role of Splunc1 as well as host defense mechanisms in the middle ear. ..
- Ramachandran S, Osterhaus S, Parekh K, Jacobi A, Behlke M, McCray P. SYVN1, NEDD8, and FBXO2 Proteins Regulate ΔF508 Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Ubiquitin-mediated Proteasomal Degradation. J Biol Chem. 2016;291:25489-25504 pubmed..It suggests that SYVN1 and FBXO2 represent two distinct multiprotein complexes that may degrade ΔF508-CFTR in airway epithelia and identifies a new role for NEDD8 in regulating ΔF508-CFTR ubiquitination. ..