Paul McCray

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. Gray R, McCullagh B, McCray P. NETs and CF Lung Disease: Current Status and Future Prospects. Antibiotics (Basel). 2015;4:62-75 pubmed publisher
    ..We propose that CF animal models that recapitulate the human CF phenotype such as the CFTR(-/-) pig may be useful in further elucidating a role for NETs. ..
  2. Li K, Wohlford Lenane C, Channappanavar R, Park J, Earnest J, Bair T, et al. Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice. Proc Natl Acad Sci U S A. 2017;114:E3119-E3128 pubmed publisher
    ..Recombinant MERSMA bearing mutant S proteins were more virulent than the parental virus in hDPP4 KI mice. The hDPP4 KI mouse and the MERSMA provide tools to investigate disease causes and develop new therapies. ..
  3. Paemka L, McCullagh B, Abou Alaiwa M, Stoltz D, Dong Q, Randak C, et al. Monocyte derived macrophages from CF pigs exhibit increased inflammatory responses at birth. J Cyst Fibros. 2017;16:471-474 pubmed publisher
    ..In the absence of CFTR function, macrophages from newborn CF pigs exhibit an increased inflammatory response to a lipopolysaccharide challenge. This may contribute to the onset and progression of CF lung disease. ..
  4. McCray P, Pewe L, Wohlford Lenane C, Hickey M, Manzel L, Shi L, et al. Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus. J Virol. 2007;81:813-21 pubmed
    ..This model of lethal infection with SARS-CoV should be useful for studies of pathogenesis and for the development of antiviral therapies. ..
  5. Bartlett J, Meyerholz D, Wohlford Lenane C, Naumann P, Salzman N, McCray P. Increased susceptibility to otitis media in a Splunc1-deficient mouse model. Dis Model Mech. 2015;8:501-8 pubmed publisher
    ..The Splunc1(-/-) mouse model should help investigators to better understand both the biological role of Splunc1 as well as host defense mechanisms in the middle ear. ..
  6. Ramachandran S, Osterhaus S, Parekh K, Jacobi A, Behlke M, McCray P. SYVN1, NEDD8, and FBXO2 Proteins Regulate ?F508 Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Ubiquitin-mediated Proteasomal Degradation. J Biol Chem. 2016;291:25489-25504 pubmed
    ..It suggests that SYVN1 and FBXO2 represent two distinct multiprotein complexes that may degrade ?F508-CFTR in airway epithelia and identifies a new role for NEDD8 in regulating ?F508-CFTR ubiquitination. ..

Detail Information

Publications6

  1. Gray R, McCullagh B, McCray P. NETs and CF Lung Disease: Current Status and Future Prospects. Antibiotics (Basel). 2015;4:62-75 pubmed publisher
    ..We propose that CF animal models that recapitulate the human CF phenotype such as the CFTR(-/-) pig may be useful in further elucidating a role for NETs. ..
  2. Li K, Wohlford Lenane C, Channappanavar R, Park J, Earnest J, Bair T, et al. Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice. Proc Natl Acad Sci U S A. 2017;114:E3119-E3128 pubmed publisher
    ..Recombinant MERSMA bearing mutant S proteins were more virulent than the parental virus in hDPP4 KI mice. The hDPP4 KI mouse and the MERSMA provide tools to investigate disease causes and develop new therapies. ..
  3. Paemka L, McCullagh B, Abou Alaiwa M, Stoltz D, Dong Q, Randak C, et al. Monocyte derived macrophages from CF pigs exhibit increased inflammatory responses at birth. J Cyst Fibros. 2017;16:471-474 pubmed publisher
    ..In the absence of CFTR function, macrophages from newborn CF pigs exhibit an increased inflammatory response to a lipopolysaccharide challenge. This may contribute to the onset and progression of CF lung disease. ..
  4. McCray P, Pewe L, Wohlford Lenane C, Hickey M, Manzel L, Shi L, et al. Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus. J Virol. 2007;81:813-21 pubmed
    ..This model of lethal infection with SARS-CoV should be useful for studies of pathogenesis and for the development of antiviral therapies. ..
  5. Bartlett J, Meyerholz D, Wohlford Lenane C, Naumann P, Salzman N, McCray P. Increased susceptibility to otitis media in a Splunc1-deficient mouse model. Dis Model Mech. 2015;8:501-8 pubmed publisher
    ..The Splunc1(-/-) mouse model should help investigators to better understand both the biological role of Splunc1 as well as host defense mechanisms in the middle ear. ..
  6. Ramachandran S, Osterhaus S, Parekh K, Jacobi A, Behlke M, McCray P. SYVN1, NEDD8, and FBXO2 Proteins Regulate ?F508 Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Ubiquitin-mediated Proteasomal Degradation. J Biol Chem. 2016;291:25489-25504 pubmed
    ..It suggests that SYVN1 and FBXO2 represent two distinct multiprotein complexes that may degrade ?F508-CFTR in airway epithelia and identifies a new role for NEDD8 in regulating ?F508-CFTR ubiquitination. ..