Loic Le Marchand


Affiliation: University of Hawaii
Country: USA


  1. request reprint
    Le Marchand L, Wilkens L, Kolonel L, Henderson B. The MTHFR C677T polymorphism and colorectal cancer: the multiethnic cohort study. Cancer Epidemiol Biomarkers Prev. 2005;14:1198-203 pubmed
    ..It also suggests that this effect may be specific to advanced colon cancer. ..
  2. request reprint
    Le Marchand L, Haiman C, Van Den Berg D, Wilkens L, Kolonel L, Henderson B. T29C polymorphism in the transforming growth factor beta1 gene and postmenopausal breast cancer risk: the Multiethnic Cohort Study. Cancer Epidemiol Biomarkers Prev. 2004;13:412-5 pubmed
    ..Given the strong biological rationale and the scarce and divergent epidemiologic data to date, additional investigations of the relationship between breast cancer and genetic variants in the TGF-beta signaling pathway appear warranted. ..
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    Le Marchand L, Seifried A, Lum Jones A, Donlon T, Wilkens L. Association of the cyclin D1 A870G polymorphism with advanced colorectal cancer. JAMA. 2003;290:2843-8 pubmed
    ..The CCND1 870A allele may be associated with colorectal cancer, and particularly with forms of the disease that result in severe morbidity and mortality. ..
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    Le Marchand L, Saltzman B, Hankin J, Wilkens L, Franke A, Morris S, et al. Sun exposure, diet, and melanoma in Hawaii Caucasians. Am J Epidemiol. 2006;164:232-45 pubmed
    ..These data provide additional evidence for the association of constitutional susceptibility factors, intense sun exposure (particularly before age 20 years), and alcohol consumption with melanoma risk. ..
  5. Le Marchand L, White K, Nomura A, Wilkens L, Selhub J, Tiirikainen M, et al. Plasma levels of B vitamins and colorectal cancer risk: the multiethnic cohort study. Cancer Epidemiol Biomarkers Prev. 2009;18:2195-201 pubmed publisher
    ..An inverse association with plasma folate was also observed among individuals with a low level of alcohol intake. These data suggest an independent role for vitamin B6 in reducing colorectal cancer risk. ..
  6. Pirie A, Guo Q, Kraft P, Canisius S, Eccles D, Rahman N, et al. Common germline polymorphisms associated with breast cancer-specific survival. Breast Cancer Res. 2015;17:58 pubmed publisher
    ..Larger studies from multinational collaborations are necessary to increase the power to detect associations, between common variants and prognosis, at more stringent significance levels. ..
  7. Campa D, Barrdahl M, Gaudet M, Black A, Chanock S, Diver W, et al. Genetic risk variants associated with in situ breast cancer. Breast Cancer Res. 2015;17:82 pubmed publisher
  8. Rudolph A, Fasching P, Behrens S, Eilber U, Bolla M, Wang Q, et al. A comprehensive evaluation of interaction between genetic variants and use of menopausal hormone therapy on mammographic density. Breast Cancer Res. 2015;17:110 pubmed publisher
    ..Given the moderate size of the interactions observed, larger studies are needed to identify genetic modifiers of the association of MHT use with mammographic density. ..
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    Le Marchand L, Donlon T, Seifried A, Kaaks R, Rinaldi S, Wilkens L. Association of a common polymorphism in the human GH1 gene with colorectal neoplasia. J Natl Cancer Inst. 2002;94:454-60 pubmed
    ..01). The human T1663A GH1 gene polymorphism, which may confer lower levels of GH and IGF-I, appears to be associated with a decreased risk of colorectal cancer. ..

More Information


  1. request reprint
    Le Marchand L, Donlon T, Kolonel L, Henderson B, Wilkens L. Estrogen metabolism-related genes and breast cancer risk: the multiethnic cohort study. Cancer Epidemiol Biomarkers Prev. 2005;14:1998-2003 pubmed
    ..They also provide support for an inverse association between CYP1A2*1F and breast cancer, which is consistent with the observation of lower circulating estrogen levels in premenopausal women with the CC genotype in a previous study. ..
  2. Le Marchand L, Wang H, Rinaldi S, Kaaks R, Vogt T, Yokochi L, et al. Associations of plasma C-peptide and IGFBP-1 levels with risk of colorectal adenoma in a multiethnic population. Cancer Epidemiol Biomarkers Prev. 2010;19:1471-7 pubmed publisher
    ..This study suggests that hyperinsulinemia and IGF hormones may act as etiologic factors in colorectal carcinogenesis, as early as during adenoma formation. ..
  3. Petridis C, Brook M, Shah V, Kohut K, Gorman P, Caneppele M, et al. Genetic predisposition to ductal carcinoma in situ of the breast. Breast Cancer Res. 2016;18:22 pubmed publisher
    ..0x10(-8). In conclusion, this study provides the strongest evidence to date of a shared genetic susceptibility for IDC and DCIS. Studies with larger numbers of DCIS are needed to determine if IDC or DCIS specific loci exist. ..
  4. Haiman C, Garcia R, Hsu C, Xia L, Ha H, Sheng X, et al. Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort. BMC Cancer. 2009;9:43 pubmed publisher