Loic Le Marchand
Affiliation: University of Hawaii
Le Marchand L, Wilkens L, Kolonel L, Henderson B. The MTHFR C677T polymorphism and colorectal cancer: the multiethnic cohort study. Cancer Epidemiol Biomarkers Prev. 2005;14:1198-203 pubmed
..It also suggests that this effect may be specific to advanced colon cancer. ..
Le Marchand L, Haiman C, Van Den Berg D, Wilkens L, Kolonel L, Henderson B. T29C polymorphism in the transforming growth factor beta1 gene and postmenopausal breast cancer risk: the Multiethnic Cohort Study. Cancer Epidemiol Biomarkers Prev. 2004;13:412-5 pubmed
..Given the strong biological rationale and the scarce and divergent epidemiologic data to date, additional investigations of the relationship between breast cancer and genetic variants in the TGF-beta signaling pathway appear warranted. ..
Le Marchand L, Seifried A, Lum Jones A, Donlon T, Wilkens L. Association of the cyclin D1 A870G polymorphism with advanced colorectal cancer. JAMA. 2003;290:2843-8 pubmed
..The CCND1 870A allele may be associated with colorectal cancer, and particularly with forms of the disease that result in severe morbidity and mortality. ..
Le Marchand L, Saltzman B, Hankin J, Wilkens L, Franke A, Morris S, et al
. Sun exposure, diet, and melanoma in Hawaii Caucasians. Am J Epidemiol. 2006;164:232-45 pubmed
..These data provide additional evidence for the association of constitutional susceptibility factors, intense sun exposure (particularly before age 20 years), and alcohol consumption with melanoma risk. ..
Le Marchand L, White K, Nomura A, Wilkens L, Selhub J, Tiirikainen M, et al
. Plasma levels of B vitamins and colorectal cancer risk: the multiethnic cohort study. Cancer Epidemiol Biomarkers Prev. 2009;18:2195-201 pubmed publisher
..An inverse association with plasma folate was also observed among individuals with a low level of alcohol intake. These data suggest an independent role for vitamin B6 in reducing colorectal cancer risk. ..
Pirie A, Guo Q, Kraft P, Canisius S, Eccles D, Rahman N, et al
. Common germline polymorphisms associated with breast cancer-specific survival. Breast Cancer Res. 2015;17:58 pubmed publisher
..Larger studies from multinational collaborations are necessary to increase the power to detect associations, between common variants and prognosis, at more stringent significance levels. ..
Campa D, Barrdahl M, Gaudet M, Black A, Chanock S, Diver W, et al
. Genetic risk variants associated with in situ breast cancer. Breast Cancer Res. 2015;17:82 pubmed publisher
Rudolph A, Fasching P, Behrens S, Eilber U, Bolla M, Wang Q, et al
. A comprehensive evaluation of interaction between genetic variants and use of menopausal hormone therapy on mammographic density. Breast Cancer Res. 2015;17:110 pubmed publisher
..Given the moderate size of the interactions observed, larger studies are needed to identify genetic modifiers of the association of MHT use with mammographic density. ..
Le Marchand L, Donlon T, Seifried A, Kaaks R, Rinaldi S, Wilkens L. Association of a common polymorphism in the human GH1 gene with colorectal neoplasia. J Natl Cancer Inst. 2002;94:454-60 pubmed
..01). The human T1663A GH1 gene polymorphism, which may confer lower levels of GH and IGF-I, appears to be associated with a decreased risk of colorectal cancer. ..