Marina Guizzetti

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint In vivo ethanol decreases phosphorylated MAPK and p70S6 kinase in the developing rat brain
    Ryozo Tsuji
    Department of Environmental Health, University of Washington, 4225 Roosevelt Way NE, 100 Seattle, WA 98105 6099, USA
    Neuroreport 14:1395-9. 2003
  2. ncbi request reprint Neurotoxicity of pesticides: a brief review
    Lucio G Costa
    Dept of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
    Front Biosci 13:1240-9. 2008
  3. ncbi request reprint Cholesterol homeostasis in the developing brain: a possible new target for ethanol
    M Guizzetti
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle 98105, USA
    Hum Exp Toxicol 26:355-60. 2007
  4. ncbi request reprint Ethanol induces cholesterol efflux and up-regulates ATP-binding cassette cholesterol transporters in fetal astrocytes
    Marina Guizzetti
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA
    J Biol Chem 282:18740-9. 2007
  5. ncbi request reprint Inorganic lead activates the mitogen-activated protein kinase kinase-mitogen-activated protein kinase-p90(RSK) signaling pathway in human astrocytoma cells via a protein kinase C-dependent mechanism
    Hailing Lu
    Department of Environmental, University of Washington, Seattle, Washington 98105, USA
    J Pharmacol Exp Ther 300:818-23. 2002
  6. pmc Modulation of neuritogenesis by astrocyte muscarinic receptors
    Marina Guizzetti
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA
    J Biol Chem 283:31884-97. 2008
  7. ncbi request reprint Effect of organophosphorus insecticides and their metabolites on astroglial cell proliferation
    Marina Guizzetti
    Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way N E 100, Seattle, WA 98105, USA
    Toxicology 215:182-90. 2005
  8. ncbi request reprint Disruption of cholesterol homeostasis in the developing brain as a potential mechanism contributing to the developmental neurotoxicity of ethanol: an hypothesis
    Marina Guizzetti
    Department of Environmental and Occupational Health Sciences, School of Public Health and Community Medicine, Toxicology Program, University of Washington, Seattle, WA 98105, USA
    Med Hypotheses 64:563-7. 2005
  9. ncbi request reprint Role of phospholipase D signaling in ethanol-induced inhibition of carbachol-stimulated DNA synthesis of 1321N1 astrocytoma cells
    Marina Guizzetti
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA
    J Neurochem 90:646-53. 2004
  10. ncbi request reprint Nuclear factor kappaB activation by muscarinic receptors in astroglial cells: effect of ethanol
    M Guizzetti
    Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way Northeast 100, Seattle, WA 98105, USA
    Neuroscience 120:941-50. 2003

Research Grants

  1. Ethanol and cholesterol homeostasis in the brain
    Marina Guizzetti; Fiscal Year: 2006

Collaborators

Detail Information

Publications32

  1. ncbi request reprint In vivo ethanol decreases phosphorylated MAPK and p70S6 kinase in the developing rat brain
    Ryozo Tsuji
    Department of Environmental Health, University of Washington, 4225 Roosevelt Way NE, 100 Seattle, WA 98105 6099, USA
    Neuroreport 14:1395-9. 2003
    ..These results suggest that phosphorylation of MAPK and p70S6 kinase may represent relevant targets for the developmental neurotoxicity of ethanol, and may be involved in microencephaly...
  2. ncbi request reprint Neurotoxicity of pesticides: a brief review
    Lucio G Costa
    Dept of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
    Front Biosci 13:1240-9. 2008
    ..This brief review highlights some of the main neurotoxic pesticides, their effects, and mechanisms of action...
  3. ncbi request reprint Cholesterol homeostasis in the developing brain: a possible new target for ethanol
    M Guizzetti
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle 98105, USA
    Hum Exp Toxicol 26:355-60. 2007
    ..Ethanol up-regulates the cholesterol transporter ATP binding cassette A1 and cholesterol efflux from primary astrocyte cultures without affecting cholesterol synthesis...
  4. ncbi request reprint Ethanol induces cholesterol efflux and up-regulates ATP-binding cassette cholesterol transporters in fetal astrocytes
    Marina Guizzetti
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA
    J Biol Chem 282:18740-9. 2007
    ..Ethanol did not affect cholesterol synthesis and reduced the levels of intracellular cholesterol in rat astrocytes. Retinoic acid, which induces teratogenic effects similarly to ethanol, also caused up-regulation of ABCA1 and ABCG1...
  5. ncbi request reprint Inorganic lead activates the mitogen-activated protein kinase kinase-mitogen-activated protein kinase-p90(RSK) signaling pathway in human astrocytoma cells via a protein kinase C-dependent mechanism
    Hailing Lu
    Department of Environmental, University of Washington, Seattle, Washington 98105, USA
    J Pharmacol Exp Ther 300:818-23. 2002
    ..Stimulation of DNA synthesis by lead in astrocytoma cells may be of interest in light of the observed association between exposure to lead and an increased risk of astrocytomas...
  6. pmc Modulation of neuritogenesis by astrocyte muscarinic receptors
    Marina Guizzetti
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA
    J Biol Chem 283:31884-97. 2008
    ..Taken together, these results demonstrate that cholinergic muscarinic stimulation of astrocytes induces the release of permissive factors that accelerate neuronal development...
  7. ncbi request reprint Effect of organophosphorus insecticides and their metabolites on astroglial cell proliferation
    Marina Guizzetti
    Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way N E 100, Seattle, WA 98105, USA
    Toxicology 215:182-90. 2005
    ....
  8. ncbi request reprint Disruption of cholesterol homeostasis in the developing brain as a potential mechanism contributing to the developmental neurotoxicity of ethanol: an hypothesis
    Marina Guizzetti
    Department of Environmental and Occupational Health Sciences, School of Public Health and Community Medicine, Toxicology Program, University of Washington, Seattle, WA 98105, USA
    Med Hypotheses 64:563-7. 2005
    ....
  9. ncbi request reprint Role of phospholipase D signaling in ethanol-induced inhibition of carbachol-stimulated DNA synthesis of 1321N1 astrocytoma cells
    Marina Guizzetti
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA
    J Neurochem 90:646-53. 2004
    ..Moreover, the effect of ethanol on carbachol-induced proliferation appears to be mediated, at least in part, by its ability to interact with PLD leading to a decreased synthesis of PA...
  10. ncbi request reprint Nuclear factor kappaB activation by muscarinic receptors in astroglial cells: effect of ethanol
    M Guizzetti
    Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way Northeast 100, Seattle, WA 98105, USA
    Neuroscience 120:941-50. 2003
    ....
  11. doi request reprint Sonic hedgehog in Smith-Lemli-Opitz syndrome and tumor development
    Marina Guizzetti
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA
    J Pediatr Hematol Oncol 30:641-2. 2008
  12. pmc Ethanol inhibits neuritogenesis induced by astrocyte muscarinic receptors
    Marina Guizzetti
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
    Glia 58:1395-406. 2010
    ..This study identifies a potential novel mechanism involved in the developmental effects of ethanol mediated by the interaction of ethanol with cell signaling in astrocytes, leading to an impairment in neuron-astrocyte communication...
  13. ncbi request reprint Effect of ethanol on protein kinase Czeta and p70S6 kinase activation by carbachol: a possible mechanism for ethanol-induced inhibition of glial cell proliferation
    Marina Guizzetti
    Department of Environmental Health, University of Washington, 4229 Roosevelt Way NE 100, Seattle, WA 98105, USA
    J Neurochem 82:38-46. 2002
    ..These results indicate that activation of the PKCzeta--> p70S6K pathway by M3 mAChRs may play a role in the increased DNA synthesis and may represent a target for ethanol-induced inhibition of astroglial cell proliferation...
  14. pmc Ethanol inhibits muscarinic receptor-induced axonal growth in rat hippocampal neurons
    Kathryn L VanDeMark
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA
    Alcohol Clin Exp Res 33:1945-55. 2009
    ..This study investigated the effect of ethanol on the differentiation of rat hippocampal pyramidal neurons induced by carbachol as a possible mechanism involved in the developmental neurotoxicity of ethanol...
  15. ncbi request reprint Ethanol inhibits muscarinic receptor-mediated DNA synthesis and signal transduction in human fetal astrocytes
    Marina Guizzetti
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
    Neurosci Lett 344:68-70. 2003
    ....
  16. doi request reprint Manganese inhibits the ability of astrocytes to promote neuronal differentiation
    Gennaro Giordano
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
    Toxicol Appl Pharmacol 240:226-35. 2009
    ..These results indicate that Mn, by targeting astrocytes, affects their ability to promote neuronal differentiation by a mechanism which is likely to involve oxidative stress...
  17. pmc Ethanol impairs muscarinic receptor-induced neuritogenesis in rat hippocampal slices: Role of astrocytes and extracellular matrix proteins
    Gennaro Giordano
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
    Biochem Pharmacol 82:1792-9. 2011
    ..By decreasing fibronectin and laminin levels ethanol prevents carbachol-induced neuritogenesis. These findings highlight the importance of glial-neuronal interactions as important targets in the developmental neurotoxicity of alcohol...
  18. pmc The activation of M1 muscarinic receptor signaling induces neuronal differentiation in pyramidal hippocampal neurons
    Kathryn L VanDeMark
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
    J Pharmacol Exp Ther 329:532-42. 2009
    ..Together, these results show that cholinergic stimulation of prenatal hippocampal pyramidal neurons accelerates axonal growth through the induction of Ca(2+) mobilization and the activation of PKC and especially of ERK1/2...
  19. pmc Muscarinic receptor-activated signal transduction pathways involved in the neuritogenic effect of astrocytes in hippocampal neurons
    Marina Guizzetti
    Dept of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
    Eur J Pharmacol 659:102-7. 2011
    ..Interference with these signaling pathways would be expected to impair astrocyte-neurons communication leading to impaired neuronal development...
  20. doi request reprint Assessment of cholesterol homeostasis in astrocytes and neurons
    Jing Chen
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA
    Methods Mol Biol 758:403-14. 2011
    ..Disruption in cholesterol synthesis and/or cholesterol efflux may result in cholesterol deficiency or accumulation in these cells leading to brain dysfunctions...
  21. pmc Shotgun proteomics implicates extracellular matrix proteins and protease systems in neuronal development induced by astrocyte cholinergic stimulation
    Nadia H Moore
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, USA
    J Neurochem 108:891-908. 2009
    ....
  22. ncbi request reprint Inhibition of muscarinic receptor-induced proliferation of astroglial cells by ethanol: mechanisms and implications for the fetal alcohol syndrome
    Lucio G Costa
    Department of Environmental Health, University of Washington, Seattle, WA, USA
    Neurotoxicology 23:685-91. 2002
    ..Inhibition of astroglial proliferation by ethanol may contribute to the microencephaly seen in FAS...
  23. pmc Cholesterol efflux is differentially regulated in neurons and astrocytes: implications for brain cholesterol homeostasis
    Jing Chen
    Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE, Seattle, WA 98105, USA
    Biochim Biophys Acta 1831:263-75. 2013
    ..These results are important in understanding cellular targets of therapeutic drugs under development for the treatments of conditions associated with altered cholesterol homeostasis in the CNS...
  24. ncbi request reprint Organophosphorus insecticides chlorpyrifos and diazinon and oxidative stress in neuronal cells in a genetic model of glutathione deficiency
    Gennaro Giordano
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
    Toxicol Appl Pharmacol 219:181-9. 2007
    ..These studies indicate that cytotoxicity of OPs involves generation of reactive oxygen species and is modulated by intracellular GSH, and suggest that it may involve disturbances in intracellular homeostasis of calcium...
  25. doi request reprint Quantification of synaptic structure formation in cocultures of astrocytes and hippocampal neurons
    Pamela J Roqué
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA
    Methods Mol Biol 758:361-90. 2011
    ....
  26. pmc Retinoic acid isomers up-regulate ATP binding cassette A1 and G1 and cholesterol efflux in rat astrocytes: implications for their therapeutic and teratogenic effects
    Jing Chen
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, USA
    J Pharmacol Exp Ther 338:870-8. 2011
    ..These findings suggest that retinoids affect cholesterol homeostasis in astrocytes and that this effect may be involved in both their therapeutic and teratogenic actions...
  27. pmc Prenatal Ethanol Exposure Up-Regulates the Cholesterol Transporters ATP-Binding Cassette A1 and G1 and Reduces Cholesterol Levels in the Developing Rat Brain
    Chunyan Zhou
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA
    Alcohol Alcohol 49:626-34. 2014
    ..In the present study we investigated whether similar effects could be seen in vivo...
  28. ncbi request reprint Paraoxonase (PON 1) as a biomarker of susceptibility for organophosphate toxicity
    Lucio G Costa
    Department of Environmental Health, University of Washington, Seattle, Washington 98105 6099, USA
    Biomarkers 8:1-12. 2003
    ..Low PON1 activity may also contribute to the higher sensitivity of newborns to OP toxicity...
  29. ncbi request reprint Developmental neurotoxicity of toluene: in vivo and in vitro effects on astroglial cells
    Mark Burry
    Toxicology Program, University of Washington, Seattle, WA 98105, USA
    Dev Neurosci 25:14-9. 2003
    ..These results indicate that toluene does not cause selective microencephaly; however, it affects brain weight, and appears to target developing astrocytes, possibly by inhibiting their proliferation...
  30. doi request reprint In vitro neurotoxicology: an introduction
    Lucio G Costa
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA
    Methods Mol Biol 758:1-9. 2011
    ....
  31. pmc Synaptic structure quantification in cultured neurons
    Pamela J Roqué
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington
    Curr Protoc Toxicol 60:12.22.1-32. 2014
    ....
  32. ncbi request reprint Extracts of various species of Epilobium inhibit proliferation of human prostate cells
    Annabella Vitalone
    Dept of Pharmacology of Natural Substances and General Physiology, University of Roma La Sapienza, Rome, Italy
    J Pharm Pharmacol 55:683-90. 2003
    ..This study provides some initial biological plausibility for the use of Epilobium extracts in benign prostatic hyperplasia...

Research Grants1

  1. Ethanol and cholesterol homeostasis in the brain
    Marina Guizzetti; Fiscal Year: 2006
    ..abstract_text> ..