Fernando Gomez Pinilla


Affiliation: University of California
Country: USA


  1. Ying Z, Byun H, Meng Q, Noble E, Zhang G, Yang X, et al. Biglycan gene connects metabolic dysfunction with brain disorder. Biochim Biophys Acta Mol Basis Dis. 2018;1864:3679-3687 pubmed publisher
    ..Overall results underscore the tissue-specific role of the extracellular matrix in the regulation of metabolism and brain function, and support Bgn as a key modulator for the impact of fructose across body and brain. ..
  2. Arneson D, Zhang G, Ying Z, Zhuang Y, Byun H, Ahn I, et al. Single cell molecular alterations reveal target cells and pathways of concussive brain injury. Nat Commun. 2018;9:3894 pubmed publisher
    ..Thus, single cell genomics provides unique information about how TBI impacts diverse hippocampal cell types, adding new insights into the pathogenic pathways amenable to therapeutics in TBI and related disorders. ..
  3. Tyagi E, Zhuang Y, Agrawal R, Ying Z, Gomez Pinilla F. Interactive actions of Bdnf methylation and cell metabolism for building neural resilience under the influence of diet. Neurobiol Dis. 2015;73:307-18 pubmed publisher
    ..Results support a model in which diet can build an "epigenetic memory" during brain formation that confers resilience to metabolic perturbations occurring in adulthood. ..
  4. Gomez Pinilla F, Yang X. System biology approach intersecting diet and cell metabolism with pathogenesis of brain disorders. Prog Neurobiol. 2018;169:76-90 pubmed publisher
  5. Gomez Pinilla F, Huie J, Ying Z, Ferguson A, Crown E, Baumbauer K, et al. BDNF and learning: Evidence that instrumental training promotes learning within the spinal cord by up-regulating BDNF expression. Neuroscience. 2007;148:893-906 pubmed
    ..The findings indicate that instrumental training enables learning and elevates BDNF mRNA levels within the lumbar spinal cord. BDNF is both necessary, and sufficient, to produce the enabling effect. ..
  6. Gomez Pinilla F, Nguyen T. Natural mood foods: the actions of polyphenols against psychiatric and cognitive disorders. Nutr Neurosci. 2012;15:127-33 pubmed publisher
    ..Thus, the consumption of diets enriched with polyphenols may present the potential of dietary manipulation as a non-invasive, natural, and inexpensive therapeutic means to support a healthy brain. ..
  7. Agrawal R, Noble E, Vergnes L, Ying Z, Reue K, Gomez Pinilla F. Dietary fructose aggravates the pathobiology of traumatic brain injury by influencing energy homeostasis and plasticity. J Cereb Blood Flow Metab. 2016;36:941-53 pubmed publisher
    ..These data imply that high fructose consumption exacerbates the pathology of brain trauma by further disrupting energy metabolism and brain plasticity, highlighting the impact of diet on the resilience to neurological disorders. ..
  8. Wu A, Noble E, Tyagi E, Ying Z, Zhuang Y, Gomez Pinilla F. Curcumin boosts DHA in the brain: Implications for the prevention of anxiety disorders. Biochim Biophys Acta. 2015;1852:951-61 pubmed publisher
  9. Gomez Pinilla F. Collaborative effects of diet and exercise on cognitive enhancement. Nutr Health. 2011;20:165-9 pubmed
    ..Omega 3 fatty acids and curcumin elevate levels of molecules important for synaptic plasticity such as brain-derived neurotrophic factor (BDNF), thus benefiting normal brain function and recovery events following brain insults. ..

More Information


  1. Krishna G, Agrawal R, Zhuang Y, Ying Z, Paydar A, Harris N, et al. 7,8-Dihydroxyflavone facilitates the action exercise to restore plasticity and functionality: Implications for early brain trauma recovery. Biochim Biophys Acta Mol Basis Dis. 2017;1863:1204-1213 pubmed publisher
  2. Meng Q, Zhuang Y, Ying Z, Agrawal R, Yang X, Gomez Pinilla F. Traumatic Brain Injury Induces Genome-Wide Transcriptomic, Methylomic, and Network Perturbations in Brain and Blood Predicting Neurological Disorders. EBioMedicine. 2017;16:184-194 pubmed publisher
  3. Agrawal R, Tyagi E, Vergnes L, Reue K, Gomez Pinilla F. Coupling energy homeostasis with a mechanism to support plasticity in brain trauma. Biochim Biophys Acta. 2014;1842:535-46 pubmed publisher
    ..Overall, the results emphasize the interactive action of metabolic and plasticity signals for supporting neurological health. ..
  4. Agrawal R, Noble E, Tyagi E, Zhuang Y, Ying Z, Gomez Pinilla F. Flavonoid derivative 7,8-DHF attenuates TBI pathology via TrkB activation. Biochim Biophys Acta. 2015;1852:862-72 pubmed publisher
    ..Since metabolic dysfunction is an important risk factor for the development of neurological and psychiatric disorders, these results set a precedent for the therapeutic use of 7,8-DHF in a larger context. ..
  5. Fernandes J, Arida R, Gomez Pinilla F. Physical exercise as an epigenetic modulator of brain plasticity and cognition. Neurosci Biobehav Rev. 2017;80:443-456 pubmed publisher
    ..The understanding of how exercise promotes long-term cognitive effects is crucial for directing the power of exercise to reduce the burden of neurological and psychiatric disorders. ..
  6. Jiménez Maldonado A, Ying Z, Byun H, Gomez Pinilla F. Short-term fructose ingestion affects the brain independently from establishment of metabolic syndrome. Biochim Biophys Acta Mol Basis Dis. 2018;1864:24-33 pubmed publisher
    ..These results advocate that a short period of fructose can influence brain plasticity without a major peripheral metabolic dysfunction. ..
  7. Gomez Pinilla F, Vaynman S, Ying Z. Brain-derived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognition. Eur J Neurosci. 2008;28:2278-87 pubmed publisher
    ..These findings suggest that the effects of exercise on synaptic plasticity and cognitive function involve elements of energy metabolism, and that BDNF seems to work at the interface between the two processes as a metabotrophin. ..
  8. Gomez Pinilla F, Zhuang Y, Feng J, Ying Z, Fan G. Exercise impacts brain-derived neurotrophic factor plasticity by engaging mechanisms of epigenetic regulation. Eur J Neurosci. 2011;33:383-90 pubmed publisher
    ..Reported information about the impact of a behavior, inherently involved in the daily human routine, on the epigenome opens exciting new directions and therapeutic opportunities in the war against neurological and psychiatric disorders. ..
  9. Gomez Pinilla F, Ying Z, Roy R, Hodgson J, Edgerton V. Afferent input modulates neurotrophins and synaptic plasticity in the spinal cord. J Neurophysiol. 2004;92:3423-32 pubmed
    ..Combined, these results indicate that the level of supraspinal and muscle afferent input plays an important role in modulating the levels of BDNF and NT-3 in the spinal cord. ..