Pradipta Ghosh

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc A structural determinant that renders G alpha(i) sensitive to activation by GIV/girdin is required to promote cell migration
    Mikel Garcia-Marcos
    Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 285:12765-77. 2010
  2. pmc The untapped potential of tyrosine-based G protein signaling
    Pradipta Ghosh
    Department of Medicine and Department of Cell and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093 0651, United States Electronic address
    Pharmacol Res 105:99-107. 2016
  3. pmc Cyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration-proliferation dichotomy
    Deepali Bhandari
    Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093 0651 Department of Chemistry and Biochemistry, California State University Long Beach, Long Beach, CA 90840 9507
    Proc Natl Acad Sci U S A 112:E4874-83. 2015
  4. pmc Gastric adenocarcinoma inducing portal hypertension: a rare presentation
    Pradipta Ghosh
    Department of Medicine, Division of Gastroenterology and Hepatology, University of California, San Diego, CA 92161, USA
    World J Gastroenterol 13:960-3. 2007
  5. pmc GIV/Girdin is a rheostat that fine-tunes growth factor signals during tumor progression
    Pradipta Ghosh
    Department of Medicine, School of Medicine, University of California San Diego, La Jolla, CA, USA
    Cell Adh Migr 5:237-48. 2011
  6. pmc A G{alpha}i-GIV molecular complex binds epidermal growth factor receptor and determines whether cells migrate or proliferate
    Pradipta Ghosh
    Department of Cellular and Molecular Medicine and Medicine, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Mol Biol Cell 21:2338-54. 2010
  7. pmc Focal adhesions are foci for tyrosine-based signal transduction via GIV/Girdin and G proteins
    Inmaculada López-Sánchez
    Department of Medicine, University of California, San Diego, School of Medicine, La Jolla, CA 92093
    Mol Biol Cell 26:4313-24. 2015
  8. pmc A GDI (AGS3) and a GEF (GIV) regulate autophagy by balancing G protein activity and growth factor signals
    Mikel Garcia-Marcos
    Departments of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Mol Biol Cell 22:673-86. 2011
  9. pmc Tyrosine phosphorylation of the Gα-interacting protein GIV promotes activation of phosphoinositide 3-kinase during cell migration
    Changsheng Lin
    Department of Medicine, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA
    Sci Signal 4:ra64. 2011
  10. pmc Protein kinase C-theta (PKCθ) phosphorylates and inhibits the guanine exchange factor, GIV/Girdin
    Inmaculada López-Sánchez
    Department of Medicine, University of California at San Diego School of Medicine, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 110:5510-5. 2013

Collaborators

  • Irina Kufareva
  • Shalini Singh
  • Ajay Goel
  • Barbara H Jung
  • Rodrigo Jover
  • JESSE HAY
  • Ulrich Peter Rohr
  • Mikel Garcia-Marcos
  • Karl Willert
  • Robert R Henry
  • Paul A Randazzo
  • Ekihiro Seki
  • Samuel B Ho
  • David A Brenner
  • Sonia Ramamoorthy
  • Ruben Abagyan
  • Mario Chojkier
  • Inmaculada López-Sánchez
  • Nicolas Aznar
  • Krishna K Midde
  • Ying Dunkel
  • Yash Mittal
  • I Chung Lo
  • Nicholas Kalogriopoulos
  • Gary S Ma
  • Marilyn G Farquhar
  • Vijay Gupta
  • Deepali Bhandari
  • Jeffrey K Lee
  • Changsheng Lin
  • Jason Ear
  • Yelena Pavlova
  • Roland El Ghazal
  • Vanessa Taupin
  • Anthony Leyme
  • Ingrid Niesman
  • Shabnam Pedram
  • Fiona Murray
  • Krishna Midde
  • Christopher Lord
  • Majid Ghassemian
  • Frederick D Park
  • Mark von Zastrow
  • Monica Macal
  • Juan Bautista Blanco-Canosa
  • Lee Swanson
  • Cristina C Rohena
  • Arjun Patel
  • Linda P Joosen
  • Scott C Johns
  • Xin Yin
  • Mark M Fuster
  • Elina I Zuniga
  • Jorge Barbazan
  • Theodore P Ciaraldi
  • Firooz Kabir
  • Miguel Abal
  • Richard L Gallo
  • Adam L Maddox
  • Klaus Peter Janssen
  • Honghui Wang
  • Andrew To
  • Arthur Marivin
  • Emi Sato
  • Ulrich Nitsche
  • Nakon Aroonsakool
  • Yoon Seok Roh
  • Andrea Murányi
  • Kandavel Shanmugam
  • Samuele De Minicis
  • Michael Lam
  • Xiaoyi Mi
  • Andrew Ong
  • Dimple Notani
  • Shekar Menon
  • Susan Ferro-Novick
  • Deborah Nycz
  • Ganga D Madduri
  • Valerie McWhorter
  • Jennifer Kum
  • Mary L Krinsky
  • Ryan Olson
  • Misty Payne
  • John M Carethers

Detail Information

Publications39

  1. pmc A structural determinant that renders G alpha(i) sensitive to activation by GIV/girdin is required to promote cell migration
    Mikel Garcia-Marcos
    Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 285:12765-77. 2010
    ....
  2. pmc The untapped potential of tyrosine-based G protein signaling
    Pradipta Ghosh
    Department of Medicine and Department of Cell and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093 0651, United States Electronic address
    Pharmacol Res 105:99-107. 2016
    ..The fundamental principles of this emerging paradigm and its pharmacologic potential are discussed. ..
  3. pmc Cyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration-proliferation dichotomy
    Deepali Bhandari
    Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093 0651 Department of Chemistry and Biochemistry, California State University Long Beach, Long Beach, CA 90840 9507
    Proc Natl Acad Sci U S A 112:E4874-83. 2015
    ....
  4. pmc Gastric adenocarcinoma inducing portal hypertension: a rare presentation
    Pradipta Ghosh
    Department of Medicine, Division of Gastroenterology and Hepatology, University of California, San Diego, CA 92161, USA
    World J Gastroenterol 13:960-3. 2007
    ..Pagetoid spread of cancer cells likely caused early metastasis and the unusual presentation. We also discussed the pathophysiology of development of portal hypertension in association with malignancies...
  5. pmc GIV/Girdin is a rheostat that fine-tunes growth factor signals during tumor progression
    Pradipta Ghosh
    Department of Medicine, School of Medicine, University of California San Diego, La Jolla, CA, USA
    Cell Adh Migr 5:237-48. 2011
    ..Based on the fact that GIV grades incoming signals initiated by ligand-activated receptors by linking them to cyclical activation of G proteins, we propose that GIV is a molecular rheostat for signal transduction...
  6. pmc A G{alpha}i-GIV molecular complex binds epidermal growth factor receptor and determines whether cells migrate or proliferate
    Pradipta Ghosh
    Department of Cellular and Molecular Medicine and Medicine, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Mol Biol Cell 21:2338-54. 2010
    ..Thus, inclusion or exclusion of GIV's GEF motif, which activates Galphai, modulates EGFR signaling, generates migration-proliferation dichotomy, and most likely influences cancer progression...
  7. pmc Focal adhesions are foci for tyrosine-based signal transduction via GIV/Girdin and G proteins
    Inmaculada López-Sánchez
    Department of Medicine, University of California, San Diego, School of Medicine, La Jolla, CA 92093
    Mol Biol Cell 26:4313-24. 2015
    ..Thus GIV-GEF serves as a unifying platform for integration and amplification of adhesion (mechanical) and growth factor (chemical) signals during cancer progression. ..
  8. pmc A GDI (AGS3) and a GEF (GIV) regulate autophagy by balancing G protein activity and growth factor signals
    Mikel Garcia-Marcos
    Departments of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Mol Biol Cell 22:673-86. 2011
    ..These results provide mechanistic insights into how reversible modulation of Gα(i3) activity by AGS3 and GIV maintains the delicate equilibrium between promotion and inhibition of autophagy...
  9. pmc Tyrosine phosphorylation of the Gα-interacting protein GIV promotes activation of phosphoinositide 3-kinase during cell migration
    Changsheng Lin
    Department of Medicine, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA
    Sci Signal 4:ra64. 2011
    ..These results suggest a mechanism by which multiple receptors activate PI3K through tyrosine phosphorylation of GIV, thereby making the GIV-PI3K interaction a potential therapeutic target within the PI3K-Akt pathway...
  10. pmc Protein kinase C-theta (PKCθ) phosphorylates and inhibits the guanine exchange factor, GIV/Girdin
    Inmaculada López-Sánchez
    Department of Medicine, University of California at San Diego School of Medicine, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 110:5510-5. 2013
    ..This phosphoevent constitutes the only regulatory pathway described for terminating signaling by any of the growing family of nonreceptor GEFs that modulate G-protein activity...
  11. pmc Functional characterization of the guanine nucleotide exchange factor (GEF) motif of GIV protein reveals a threshold effect in signaling
    Mikel Garcia-Marcos
    Department of Cellular and Molecular Medicine, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 109:1961-6. 2012
    ..This functional characterization of GIV's GEF motif provides insights into the molecular interactions between nonreceptor GEFs and G proteins and the mechanisms that govern this signal transduction pathway...
  12. pmc Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin
    Changsheng Lin
    Department of Medicine, University of California, San Diego, School of Medicine, CA 92093
    Mol Biol Cell 25:3654-71. 2014
    ....
  13. pmc Expression of GIV/Girdin, a metastasis-related protein, predicts patient survival in colon cancer
    Mikel Garcia-Marcos
    Department of Cellular and Molecular Medicine, George E Palade Laboratories, University of California, San Diego School of Medicine, La Jolla, CA 92093 0651, USA
    FASEB J 25:590-9. 2011
    ..We conclude that GIV-fl is a novel metastasis-related protein and an independent adverse prognosticator that may serve as a useful adjunct to traditional staging strategies in colorectal carcinoma...
  14. pmc Heterotrimeric G protein signaling via GIV/Girdin: Breaking the rules of engagement, space, and time
    Nicolas Aznar
    Department of Medicine, University of California at San Diego, La Jolla, CA, USA
    Bioessays 38:379-93. 2016
    ..Here, we provide the most complete up-to-date review of the molecular mechanisms that govern the unique spatiotemporal aspects of non-canonical G protein activation by GIV and the relevance of this new paradigm in health and disease. ..
  15. pmc Src homology domain 2-containing protein-tyrosine phosphatase-1 (SHP-1) binds and dephosphorylates G(alpha)-interacting, vesicle-associated protein (GIV)/Girdin and attenuates the GIV-phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway
    Yash Mittal
    Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 286:32404-15. 2011
    ..We conclude that SHP-1 antagonizes the action of receptor and non-receptor-tyrosine kinases on GIV and down-regulates the phospho-GIV-PI3K-Akt axis of signaling...
  16. pmc GIV is a nonreceptor GEF for G alpha i with a unique motif that regulates Akt signaling
    Mikel Garcia-Marcos
    Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 106:3178-83. 2009
    ....
  17. pmc Activation of Galphai3 triggers cell migration via regulation of GIV
    Pradipta Ghosh
    Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Cell Biol 182:381-93. 2008
    ....
  18. pmc GIV/Girdin activates Gαi and inhibits Gαs via the same motif
    Vijay Gupta
    Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093
    Proc Natl Acad Sci U S A 113:E5721-30. 2016
    ..Our findings also illuminate how such modulation of two opposing Gα proteins integrates downstream signals and cellular responses. ..
  19. pmc STAT3 protein up-regulates Gα-interacting vesicle-associated protein (GIV)/Girdin expression, and GIV enhances STAT3 activation in a positive feedback loop during wound healing and tumor invasion/metastasis
    Ying Dunkel
    Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 287:41667-83. 2012
    ....
  20. pmc Biochemical, Biophysical and Cellular Techniques to Study the Guanine Nucleotide Exchange Factor, GIV/Girdin
    Pradipta Ghosh
    Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California
    Curr Protoc Chem Biol 8:265-298. 2016
    ..Here we provide the most up-to-date overview of protocols that have generated most of what we know today about noncanonical G protein activation by GIV and its relevance in health and disease. © 2016 by John Wiley & Sons, Inc...
  21. pmc Activation of G proteins by GIV-GEF is a pivot point for insulin resistance and sensitivity
    Gary S Ma
    Department of Medicine, University of California, San Diego, School of Medicine, La Jolla, CA 92093
    Mol Biol Cell 26:4209-23. 2015
    ..We also provide evidence that GIV-GEF serves as therapeutic target for exogenous manipulation of physiological insulin response and reversal of IR in skeletal muscles. ..
  22. pmc Activation of Gαi at the Golgi by GIV/Girdin imposes finiteness in Arf1 signaling
    I Chung Lo
    Departments of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Dev Cell 33:189-203. 2015
    ..These findings define a paradigm in non-canonical G protein signaling at the Golgi, which places GIV-GEF at the crossroads between signals gated by the trimeric G proteins and the Arf family of monomeric GTPases...
  23. pmc AMP-activated protein kinase fortifies epithelial tight junctions during energetic stress via its effector GIV/Girdin
    Nicolas Aznar
    Department of Medicine, University of California, San Diego, San Diego, United States
    elife 5:. 2016
    ..This work defines a fundamental homeostatic mechanism by which the AMPK-GIV axis reinforces cell junctions against stress-induced collapse and also provides mechanistic insight into the tumor-suppressive action of Metformin...
  24. pmc Therapeutic effects of cell-permeant peptides that activate G proteins downstream of growth factors
    Gary S Ma
    Department of Medicine, University of California, San Diego School of Medicine, La Jolla, CA 92093 and
    Proc Natl Acad Sci U S A 112:E2602-10. 2015
    ..Thus, TAT-GIV peptides provide a novel and versatile tool to manipulate Gαi activation downstream of growth factors in a diverse array of pathophysiologic conditions. ..
  25. pmc GIV/girdin binds exocyst subunit-Exo70 and regulates exocytosis of GLUT4 storage vesicles
    Inmaculada López-Sánchez
    Department of Medicine, University of California, San Diego School of Medicine, La Jolla, CA 92093, USA
    Biochem Biophys Res Commun 468:287-93. 2015
    ..These findings suggest a role of GIV in coordinating key signaling and trafficking events of metabolic insulin response. ..
  26. pmc Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling
    Nicolas Aznar
    Department of Medicine, University of California, San Diego, San Diego, United States
    elife 4:e07091. 2015
    ..Thus, Daple activates Gαi and enhances non-canonical Wnt signaling by FZDRs, and its dysregulation can impact both tumor initiation and progression to metastasis. ..
  27. pmc G Protein binding sites on Calnuc (nucleobindin 1) and NUCB2 (nucleobindin 2) define a new class of G(alpha)i-regulatory motifs
    Mikel Garcia-Marcos
    Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 286:28138-49. 2011
    ..These findings provide the structural basis for the properties of Calnuc and NUCB2 binding to Gα subunits and its regulation by calcium ions...
  28. pmc GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis
    Inmaculada López-Sánchez
    Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Nat Commun 5:4451. 2014
    ..We also provide evidence that GIV may serve as a biomarker for progression of fibrosis after liver injury and a therapeutic target for arresting and/or reversing HSC activation during liver fibrosis. ..
  29. pmc Girdin (GIV) Expression as a Prognostic Marker of Recurrence in Mismatch Repair-Proficient Stage II Colon Cancer
    Pradipta Ghosh
    Departments of Medicine and Cell and Molecular Medicine, University of California, San Diego, California
    Clin Cancer Res 22:3488-98. 2016
    ..Prognostic markers that identify patients with stage II colon cancers who are at the risk of recurrence are essential to personalize therapy. We evaluated the potential of GIV/Girdin as a predictor of recurrence risk in such patients...
  30. pmc Sequential interactions with Sec23 control the direction of vesicle traffic
    Christopher Lord
    Department of Cellular and Molecular Medicine, Howard Hughes Medical Institute, University of California at San Diego, La Jolla, California 92093 0668, USA
    Nature 473:181-6. 2011
    ..These events are conserved in mammalian cells...
  31. pmc Glycan Sulfation Modulates Dendritic Cell Biology and Tumor Growth
    Roland El Ghazal
    VA San Diego Healthcare System, Medical and Research Sections, La Jolla, CA 92161 Department of Medicine, Division of Pulmonary and Critical Care, University of California San Diego, La Jolla, CA 92037
    Neoplasia 18:294-306. 2016
    ..These findings indicate the genetic importance of DC heparan sulfate proteoglycans in tumor growth and may guide therapeutic development of novel strategies to target syndecan-4 and heparan sulfate in cancer. ..
  32. pmc Evidence for colorectal sarcomatoid carcinoma arising from tubulovillous adenoma
    Jeffrey K Lee
    Department of Medicine, University of California, San Diego UC 303 MC 0063, 9500 Gilman Drive, La Jolla CA 92093 0063, United States
    World J Gastroenterol 14:4389-94. 2008
    ..This observation supports the "monoclonal theory" of pathogenesis with an adenoma-sarcoma progression with or without an intermediate stage of carcinoma...
  33. pmc Generalized megaviscera of lupus: refractory intestinal pseudo-obstruction, ureterohydronephrosis and megacholedochus
    Frederick D Park
    Department of Internal Medicine, Division of Gastroenterology, University of California, San Diego School of Medicine, George Palade Laboratories for Cellular and Molecular Medicine, 9500 Gilman Drive, La Jolla, California 92093 0651, United States
    World J Gastroenterol 15:3555-9. 2009
    ..Thus, early recognition and timely initiation of treatment may be the key to recover visceral peristaltic function in patients with GML...
  34. ncbi request reprint Mesenteric panniculitis and sclerosing mesenteritis: a continuum of inflammation fibrosis
    Pradipta Ghosh
    Department of Medicine, Division of Gastroenterology and Hepatology, University of California San Diego, USA
    Clin Gastroenterol Hepatol 5:A32. 2007
  35. ncbi request reprint Peritoneal mice implicated in intestinal obstruction: report of a case and review of the literature
    Pradipta Ghosh
    Department of Medicine, University of California, San Diego, 92161, USA
    J Clin Gastroenterol 40:427-30. 2006
    ..Implication of these concretions in an acute abdomen is a rare clinical entity...
  36. ncbi request reprint Sugar rush in the colon: why incidental findings on PET scan justify colonoscopy?
    Pradipta Ghosh
    Am J Gastroenterol 102:2609-10. 2007
  37. doi request reprint Nonmetastatic cancer of the colon associated with pyogenic liver abscess
    Jeffrey K Lee
    Am J Gastroenterol 103:798-9. 2008