Douglas Feinstein


Affiliation: University of Illinois at Chicago
Country: USA


  1. Polak P, Lin S, Pelligrino D, Feinstein D. The blood-brain barrier-permeable catechol-O-methyltransferase inhibitor dinitrocatechol suppresses experimental autoimmune encephalomyelitis. J Neuroimmunol. 2014;276:135-41 pubmed publisher
    ..Spinal cord COMT mRNA levels were not increased during EAE, but were found increased in the frontal cortex of MS patients. These results suggest that COMT inhibitors could provide benefit to MS patients. ..
  2. Kalinin S, González Prieto M, Scheiblich H, Lisi L, Kusumo H, Heneka M, et al. Transcriptome analysis of alcohol-treated microglia reveals downregulation of beta amyloid phagocytosis. J Neuroinflammation. 2018;15:141 pubmed publisher
    ..Our results define alterations that occur to microglial gene expression following alcohol exposure and suggest that alcohol effects on phagocytosis could contribute to the development of Alzheimer's disease. ..
  3. Dupree J, Feinstein D. Influence of diet on axonal damage in the EAE mouse model of multiple sclerosis. J Neuroimmunol. 2018;322:9-14 pubmed publisher
    ..These findings demonstrate that differences in axonal pathology occur in the absence of observable differences in clinical signs, and that inter-study comparisons may be confounded by differences in dietary care. ..
  4. Boullerne A, Skias D, Hartman E, Testai F, Kalinin S, Polak P, et al. A single-nucleotide polymorphism in serine-threonine kinase 11, the gene encoding liver kinase B1, is a risk factor for multiple sclerosis. ASN Neuro. 2015;7: pubmed publisher
    ..The lower disease severity observed in the context of HLA-DRB1*1501 combined with limited in vitro studies raises the provocative possibility that cells harboring the STK11-SNP could be targeted by drugs which increase metabolic stress. ..
  5. Feinstein D, Kalinin S, Braun D. Causes, consequences, and cures for neuroinflammation mediated via the locus coeruleus: noradrenergic signaling system. J Neurochem. 2016;139 Suppl 2:154-178 pubmed publisher
    ..This article is part of the 60th Anniversary special issue. ..
  6. Marangoni M, Martynowycz M, Kuzmenko I, Braun D, Polak P, Weinberg G, et al. Membrane Cholesterol Modulates Superwarfarin Toxicity. Biophys J. 2016;110:1777-1788 pubmed publisher
    ..These findings demonstrate an affinity of superwarfarins to biomembranes and suggest that cellular responses to these agents are regulated by cholesterol content. ..
  7. Marangoni M, Braun D, Situ A, Moyano A, Kalinin S, Polak P, et al. Differential effects on glial activation by a direct versus an indirect thrombin inhibitor. J Neuroimmunol. 2016;297:159-68 pubmed publisher
    ..These results suggest that treatment with direct thrombin inhibitors may be preferable to those agents which reduce vitamin K levels and have the potential to increase glial activation. ..
  8. Lisi L, Ciotti G, Braun D, Kalinin S, Curro D, Dello Russo C, et al. Expression of iNOS, CD163 and ARG-1 taken as M1 and M2 markers of microglial polarization in human glioblastoma and the surrounding normal parenchyma. Neurosci Lett. 2017;645:106-112 pubmed publisher
    ..In contrast, no significant association was found between survival time and ARG-1 or iNOS expression. ..
  9. Braun D, Feinstein D. The locus coeruleus neuroprotective drug vindeburnol normalizes behavior in the 5xFAD transgenic mouse model of Alzheimer's disease. Brain Res. 2017;: pubmed publisher
    ..These findings suggest that cAMP-mediated increases in neurotrophic factors contribute to beneficial effects of vindeburnol within the context of LC damage, which may be of value for treatment of some neuropsychiatric symptoms of AD. ..

More Information


  1. Feinstein D, Skoff R. Glial cell biology in the Great Lakes region. J Neuroinflammation. 2016;13:69 pubmed publisher
    ..Sessions covered recent findings in the areas of microglial and astrocyte activation; age-dependent changes to glial cells, Schwann cell development and pathology, and the role of stem cells in glioma and neural regeneration. ..
  2. Changyaleket B, Deliu Z, Chignalia A, Feinstein D. Heparanase: Potential roles in multiple sclerosis. J Neuroimmunol. 2017;310:72-81 pubmed publisher
  3. Marangoni N, Kowal K, Deliu Z, Hensley K, Feinstein D. Neuroprotective and neurotrophic effects of Lanthionine Ketimine Ester. Neurosci Lett. 2018;664:28-33 pubmed publisher
    ..These results demonstrate that direct neuroprotective and neurotrophic effects of LKE likely contribute to its beneficial actions in vivo. ..