John F Engelhardt
Affiliation: University of Iowa
Lynch T, Anderson P, Rotti P, Tyler S, Crooke A, Choi S, et al
. Submucosal Gland Myoepithelial Cells Are Reserve Stem Cells That Can Regenerate Mouse Tracheal Epithelium. Cell Stem Cell. 2018;22:653-667.e5 pubmed publisher
..Thus, modulating the Lef-1 transcriptional program in MEC-derived progenitors may have regenerative medicine applications for lung diseases. ..
Rosen B, Evans T, Moll S, Gray J, Liang B, Sun X, et al
. Infection is Not Required for Mucoinflammatory Lung Disease in CFTR-knockout Ferrets. Am J Respir Crit Care Med. 2018;: pubmed publisher
..These findings implicate mucoinflammatory processes in the CF lung as pathogenic in the absence of clinically apparent bacterial and fungal infections. ..
Xie W, Lynch T, Liu X, Tyler S, Yu S, Zhou X, et al
. Sox2 modulates Lef-1 expression during airway submucosal gland development. Am J Physiol Lung Cell Mol Physiol. 2014;306:L645-60 pubmed publisher
..These studies support a model whereby Wnt signals and Sox2 dynamically regulate the expression of Lef-1 in airway epithelia and potentially also during SMG development. ..
Sun X, Olivier A, Yi Y, Pope C, Hayden H, Liang B, et al
. Gastrointestinal pathology in juvenile and adult CFTR-knockout ferrets. Am J Pathol. 2014;184:1309-22 pubmed publisher
..In summary, these studies demonstrate that the CF ferret model develops gastrointestinal pathology similar to CF patients. ..
Rosen B, Chanson M, Gawenis L, Liu J, Sofoluwe A, Zoso A, et al
. Animal and model systems for studying cystic fibrosis. J Cyst Fibros. 2018;17:S28-S34 pubmed publisher
..This short review evaluates several areas that are key to building animal and cell systems capable of modeling CF disease and testing potential treatments. ..
Swatek A, Lynch T, Crooke A, Anderson P, Tyler S, Brooks L, et al
. Depletion of Airway Submucosal Glands and TP63+KRT5+ Basal Cells in Obliterative Bronchiolitis. Am J Respir Crit Care Med. 2017;: pubmed publisher
..Global airway SC depletion may be a mechanism for pulmonary allograft failure. ..