Genomes and Genes
Affiliation: University of North Carolina
- SFRP2 regulates cardiomyogenic differentiation by inhibiting a positive transcriptional autofeedback loop of Wnt3aArjun Deb
Division of Cardiovascular Diseases and Mandel Center for Hypertension and Atherosclerosis Research, Department of Medicine, GSRB 2, Box 3178, Duke University Medical Center, Durham, North Carolina 27710, USA
Stem Cells 26:35-44. 2008..The inhibitory effects of Sfrp2 on Wnt3a expression identify Sfrp2 as a "checkpoint gene," which exerts its control on cardiomyogenesis through regulation of Wnt3a transcription...
- Myocardial-cell replacement: the science, the clinic and the futureNoel M Caplice
Division of Cardiovascular Diseases, Molecular Medicine Program, Mayo College of Medicine, Rochester, MN, USA
Nat Clin Pract Cardiovasc Med 1:90-5. 2004..Prospects for more widespread clinical application of myocardial-cell replacement and future hurdles to be overcome in this field will also be addressed...
- Mesenchymal stem cells overexpressing Akt dramatically repair infarcted myocardium and improve cardiac function despite infrequent cellular fusion or differentiationNicolas Noiseux
Department of Medicine, Brigham and Women s Hospital, Harvard University, Boston, MA 02115, USA
Mol Ther 14:840-50. 2006....
- Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repairMaria Mirotsou
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 104:1643-8. 2007..These findings reveal the key role played by Sfrp2 in mediating the paracrine effects of Akt-mesenchymal stem cells on tissue repair and identify modulation of Wnt signaling as a therapeutic target for heart disease...
- Rib fractures and death from deletion of osteoblast βcatenin in adult mice is rescued by corticosteroidsJinzhu Duan
Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, United States of America
PLoS ONE 8:e55757. 2013..We demonstrate the role of βcatenin dependent mechanisms in rib fractures and suggest that glucocorticoids, by suppressing RANKL, may have a role in treating bone loss due to aggressive osteoclastogenesis...
- Genetic modification of mesenchymal stem cells overexpressing CCR1 increases cell viability, migration, engraftment, and capillary density in the injured myocardiumJing Huang
Duke University Medical Center and Health System, DUMC 3701, Durham, NC 27701, USA
Circ Res 106:1753-62. 2010..However the expression levels of the corresponding chemokine receptors (eg, CCR1, CXCR2) in MSCs are very low. We hypothesized that this discordance may account for the poor MSC engraftment and survival...
- Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repairJinzhu Duan
Department of Medicine, McAllister Heart Institute and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA
EMBO J 31:429-42. 2012..These findings reveal that a pro-fibrotic Wnt1/βcatenin injury response is critically required for preserving cardiac function after acute ischaemic cardiac injury...
- Secreted frizzled related protein 2 protects cells from apoptosis by blocking the effect of canonical Wnt3aZhongyan Zhang
Edna and Fred L Mandel, Jr Center for Hypertension and Atherosclerosis Research, Duke University School of Medicine, Durham, NC 27710, USA
J Mol Cell Cardiol 46:370-7. 2009..These results can explain the in vivo protective effect of Sfrp2 and highlight its therapeutic potential for the ischemic heart...
- Wnt1 is a proangiogenic molecule, enhances human endothelial progenitor function, and increases blood flow to ischemic limbs in a HGF-dependent mannerCostin M Gherghe
Department of Medicine, University of North Carolina Chapel Hill, Chapel Hill, NC, USA
FASEB J 25:1836-43. 2011....
- Leptin receptor and functional effects of leptin in human endothelial progenitor cellsRobert Wolk
Mayo Foundation, St Mary s Hospital, DO 4 350, 1216 Second St SW, Rochester, MN 55902, USA
Atherosclerosis 183:131-9. 2005..These findings are relevant to leptin-mediated regulation of vasculogenesis in humans, and the association between hyperleptinemia and obesity with cardiovascular disease...
- Primary synovial sarcoma of the mitral valveDylan V Miller
Division of Anatomic Pathology, Mayo Clinic, Rochester, MN 55905, USA
Cardiovasc Pathol 14:331-3. 2005..The histopathologic diagnosis was supported by the immunohistochemical profile and the presence of the SYT-SSX1 fusion transcript identified by molecular genetic studies...
- Bone marrow-derived cardiomyocytes are present in adult human heart: A study of gender-mismatched bone marrow transplantation patientsArjun Deb
Division of Cardiovascular Diseases and Molecular Medicine Program, Mayo Clinic, Rochester, Minn 55905, USA
Circulation 107:1247-9. 2003..Recent studies have identified cardiomyocytes of extracardiac origin in transplanted human hearts, but the exact origin of these myocyte progenitors is currently unknown...
- Role of Wnts in Cardiac RepairArjun Deb; Fiscal Year: 2010..In this proposal, we will determine how Wnt1 regulates scar formation in the injured heart and aim to minimize scar formation and improve cardiac function through manipulation of Wnt signaling. ..