Ashis K Basu
Affiliation: University of Connecticut
Bose A, Pande P, Jasti V, Millsap A, Hawkins E, Rizzo C, et al
. DNA polymerases Îº and Î¶ cooperatively perform mutagenic translesion synthesis of the C8-2'-deoxyguanosine adduct of the dietary mutagen IQ in human cells. Nucleic Acids Res. 2015;43:8340-51 pubmed publisher
..We conclude that pol Îº and pol Î¶ cooperatively carry out the majority of the error-prone TLS of dG-C8-IQ, whereas pol Î· is involved primarily in its error-free bypass. ..
Weerasooriya S, Jasti V, Bose A, Spratt T, Basu A. Roles of translesion synthesis DNA polymerases in the potent mutagenicity of tobacco-specific nitrosamine-derived O2-alkylthymidines in human cells. DNA Repair (Amst). 2015;35:63-70 pubmed publisher
..This study provided important mechanistic details on how these lesions are bypassed in human cells in both error-free and error-prone manner. ..
Basu A. DNA Damage, Mutagenesis and Cancer. Int J Mol Sci. 2018;19: pubmed publisher
..This mini-review attempts to summarize this wide area that centers on DNA damage as it relates to the development of human cancer. ..
Tokarsky E, Gadkari V, Zahurancik W, Malik C, Basu A, Suo Z. Pre-steady-state kinetic investigation of bypass of a bulky guanine lesion by human Y-family DNA polymerases. DNA Repair (Amst). 2016;46:20-28 pubmed publisher
..Furthermore, hPol? displayed nucleotide concentration-dependent biphasic kinetics at the two polymerase pause sites, suggesting that multiple enzyme•DNA complexes likely exist during nucleotide incorporation. ..