Affiliation: Tulane University
Chandra S, Terragni J, Zhang G, Pradhan S, Haushka S, Johnston D, et al
. Tissue-specific epigenetics in gene neighborhoods: myogenic transcription factor genes. Hum Mol Genet. 2015;24:4660-73 pubmed publisher
..Our findings reveal the very different and complex organization of gene neighborhoods containing closely related transcription factor genes. ..
Ehrlich M, Jackson K, Tsumagari K, Camaño P, Lemmers R. Hybridization analysis of D4Z4 repeat arrays linked to FSHD. Chromosoma. 2007;116:107-16 pubmed
..Furthermore, we show that the D4Z4-like sequences present elsewhere in the genome are not tandemly arranged, like those at 4q35 and 10q26. ..
Ehrlich M, Sanchez C, Shao C, Nishiyama R, Kehrl J, Kuick R, et al
. ICF, an immunodeficiency syndrome: DNA methyltransferase 3B involvement, chromosome anomalies, and gene dysregulation. Autoimmunity. 2008;41:253-71 pubmed publisher
Ehrlich M. DNA hypomethylation in cancer cells. Epigenomics. 2009;1:239-59 pubmed publisher
..Evidence is accumulating for the biological significance and clinical relevance of DNA hypomethylation in cancer, and for cancer-linked demethylation and de novo methylation being highly dynamic processes. ..
Rauscher G, Kresovich J, Poulin M, Yan L, Macias V, Mahmoud A, et al
. Exploring DNA methylation changes in promoter, intragenic, and intergenic regions as early and late events in breast cancer formation. BMC Cancer. 2015;15:816 pubmed publisher
..In addition, we illustrate the power of combining publicly available whole-genome databases with a candidate gene approach to study cancer epigenetics. ..
Ehrlich M, Woods C, Yu M, Dubeau L, Yang F, Campan M, et al
. Quantitative analysis of associations between DNA hypermethylation, hypomethylation, and DNMT RNA levels in ovarian tumors. Oncogene. 2006;25:2636-45 pubmed
..Our results suggest that there is not a simple association of gene hypermethylation in cancer with altered DNMT RNA levels, and that this hypermethylation is neither the result nor the cause of satellite and global DNA hypomethylation. ..