I L Campbell

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. ncbi request reprint Structural and functional neuropathology in transgenic mice with CNS expression of IFN-alpha
    I L Campbell
    Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Brain Res 835:46-61. 1999
  2. ncbi request reprint Transgenic models to study the actions of cytokines in the central nervous system
    I L Campbell
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, Calif, USA
    Neuroimmunomodulation 5:126-35. 1998
  3. ncbi request reprint Transgenic mice and cytokine actions in the brain: bridging the gap between structural and functional neuropathology
    I L Campbell
    Department of Neuropharmacology, CVN 9, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Brain Res Brain Res Rev 26:327-36. 1998
  4. ncbi request reprint Structural and functional impact of the transgenic expression of cytokines in the CNS
    I L Campbell
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA
    Ann N Y Acad Sci 840:83-96. 1998
  5. ncbi request reprint Transgenic models to assess the pathogenic actions of cytokines in the central nervous system
    I L Campbell
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, CA 92037, USA
    Mol Psychiatry 2:125-9. 1997
  6. ncbi request reprint Exacerbation of lymphocytic choriomeningitis in mice treated with the inducible nitric oxide synthase inhibitor aminoguanidine
    I L Campbell
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, CA 92037, USA
    J Neuroimmunol 71:31-6. 1996
  7. pmc Late-onset chronic inflammatory encephalopathy in immune-competent and severe combined immune-deficient (SCID) mice with astrocyte-targeted expression of tumor necrosis factor
    A K Stalder
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    Am J Pathol 153:767-83. 1998
  8. ncbi request reprint Astrocyte-targeted expression of IL-12 induces active cellular immune responses in the central nervous system and modulates experimental allergic encephalomyelitis
    A Pagenstecher
    Departments of Neuropharmacology and Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 164:4481-92. 2000
  9. ncbi request reprint Transgenic expression of IFN-alpha in the central nervous system of mice protects against lethal neurotropic viral infection but induces inflammation and neurodegeneration
    Y Akwa
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 161:5016-26. 1998
  10. ncbi request reprint Induction of type 1 immune pathology in the brain following immunization without central nervous system autoantigen in transgenic mice with astrocyte-targeted expression of IL-12
    S Lassmann
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 167:5485-93. 2001

Collaborators

Detail Information

Publications83

  1. ncbi request reprint Structural and functional neuropathology in transgenic mice with CNS expression of IFN-alpha
    I L Campbell
    Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Brain Res 835:46-61. 1999
    ....
  2. ncbi request reprint Transgenic models to study the actions of cytokines in the central nervous system
    I L Campbell
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, Calif, USA
    Neuroimmunomodulation 5:126-35. 1998
    ....
  3. ncbi request reprint Transgenic mice and cytokine actions in the brain: bridging the gap between structural and functional neuropathology
    I L Campbell
    Department of Neuropharmacology, CVN 9, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Brain Res Brain Res Rev 26:327-36. 1998
    ..Integrative studies such as described here in the GFAP-cytokine transgenic mice, are providing a more thorough understanding of the actions of cytokines in the CNS and bridge the gap between structural and functional neuropathology...
  4. ncbi request reprint Structural and functional impact of the transgenic expression of cytokines in the CNS
    I L Campbell
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA
    Ann N Y Acad Sci 840:83-96. 1998
    ....
  5. ncbi request reprint Transgenic models to assess the pathogenic actions of cytokines in the central nervous system
    I L Campbell
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, CA 92037, USA
    Mol Psychiatry 2:125-9. 1997
    ..Thus, expression of specific cytokines alone in the intact CNS results in unique neuropathological alterations and functional impairments, thereby directly implicating these mediators in the pathogenesis of CNS disease...
  6. ncbi request reprint Exacerbation of lymphocytic choriomeningitis in mice treated with the inducible nitric oxide synthase inhibitor aminoguanidine
    I L Campbell
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, CA 92037, USA
    J Neuroimmunol 71:31-6. 1996
    ..These findings argue against either an anti-viral or pathogenic role of NO in LCM but rather suggest a possible protective action of this mediator...
  7. pmc Late-onset chronic inflammatory encephalopathy in immune-competent and severe combined immune-deficient (SCID) mice with astrocyte-targeted expression of tumor necrosis factor
    A K Stalder
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    Am J Pathol 153:767-83. 1998
    ..Thus, persistent astrocyte expression of murine TNF-alpha in the CNS induces a late-onset chronic inflammatory encephalopathy in which macrophage/microglial cells but not lymphocytes play a central role in mediating injury...
  8. ncbi request reprint Astrocyte-targeted expression of IL-12 induces active cellular immune responses in the central nervous system and modulates experimental allergic encephalomyelitis
    A Pagenstecher
    Departments of Neuropharmacology and Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 164:4481-92. 2000
    ....
  9. ncbi request reprint Transgenic expression of IFN-alpha in the central nervous system of mice protects against lethal neurotropic viral infection but induces inflammation and neurodegeneration
    Y Akwa
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 161:5016-26. 1998
    ..These transgenic mice provide a novel animal model in which to further evaluate the mechanisms that underlie the diverse actions of type I IFNs in the intact CNS...
  10. ncbi request reprint Induction of type 1 immune pathology in the brain following immunization without central nervous system autoantigen in transgenic mice with astrocyte-targeted expression of IL-12
    S Lassmann
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 167:5485-93. 2001
    ..These findings indicate that the cytokine milieu of a tissue can dramatically influence the development of intrinsic immune responses and associated pathology...
  11. pmc Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6
    I L Campbell
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, CA 92037
    Proc Natl Acad Sci U S A 90:10061-5. 1993
    ..These findings indicate that cytokines such as IL-6 can have a direct pathogenic role in inflammatory, infectious, and neurodegenerative CNS diseases...
  12. pmc Interferon-independent, human immunodeficiency virus type 1 gp120-mediated induction of CXCL10/IP-10 gene expression by astrocytes in vivo and in vitro
    V C Asensio
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 75:7067-77. 2001
    ....
  13. ncbi request reprint Response of glia, mast cells and the blood brain barrier, in transgenic mice expressing interleukin-3 in astrocytes, an experimental model for CNS demyelination
    H C Powell
    Veterans Administration Research Service, VAMC San Diego, La Jolla, CA, USA
    Brain Pathol 9:219-35. 1999
    ....
  14. ncbi request reprint Dynamic regulation of alpha- and beta-chemokine expression in the central nervous system during mouse hepatitis virus-induced demyelinating disease
    T E Lane
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 160:970-8. 1998
    ..These observations suggest a role for chemokines, notably CRG-2, in the initiation and maintenance of an inflammatory response following infection with MHV, which is important in contributing to demyelination...
  15. pmc Regulation of matrix metalloproteinases and their inhibitor genes in lipopolysaccharide-induced endotoxemia in mice
    A Pagenstecher
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA, USA
    Am J Pathol 157:197-210. 2000
    ..These observations highlight a dramatic shift in favor of increased expression of the MMP genes over the TIMP genes during LPS-induced endotoxemia, and suggest that MMPs may contribute to the development of organ damage in endotoxemia...
  16. ncbi request reprint Cerebral expression of multiple cytokine genes in mice with lymphocytic choriomeningitis
    I L Campbell
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, CA 92037
    J Immunol 152:716-23. 1994
    ..The close spatiotemporal relationship between expression of cytokine genes and evolution of disease in brain implicate cytokines are not only key coordinators of the host response but also as possible mediators of neuropathology in LCM...
  17. pmc Differential expression of matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase genes in the mouse central nervous system in normal and inflammatory states
    A Pagenstecher
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    Am J Pathol 152:729-41. 1998
    ..The distinct localization of TIMP-1 and MMP expression during CNS inflammation suggests a dynamic state in which the interplay between these gene products may determine both the size and resolution of the destructive inflammatory focus...
  18. ncbi request reprint Altered functional and biochemical response by CD8+ T cells that remain after tolerance
    A Murtaza
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, IMM-15, La Jolla, CA 92037, USA
    Int Immunol 13:1085-93. 2001
    ..These data demonstrate that the HA-responsive CD8(+) T cells that can be retrieved from InsHA mice after tolerance induction respond to HA as a partial agonist/antagonist...
  19. pmc Coxsackievirus B3-induced myocarditis: perforin exacerbates disease, but plays no detectable role in virus clearance
    J R Gebhard
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    Am J Pathol 153:417-28. 1998
    ..Thus, the chemokine pathway offers a second route of intervention to diminish myocarditis and its sequelae, while permitting the host to eradicate the virus...
  20. ncbi request reprint Cytokines and chemokines as mediators of protection and injury in the central nervous system assessed in transgenic mice
    J Wang
    Department of Neuropharmacology, SP315, Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Curr Top Microbiol Immunol 265:23-48. 2002
    ....
  21. pmc Macrophage/microglial-mediated primary demyelination and motor disease induced by the central nervous system production of interleukin-3 in transgenic mice
    C S Chiang
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Clin Invest 97:1512-24. 1996
    ..This transgenic model exhibits many of the features of human inflammatory demyelinating diseases including multiple sclerosis and HIV leukoencephalopathy...
  22. pmc Chemokine gene expression in the brains of mice with lymphocytic choriomeningitis
    V C Asensio
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 71:7832-40. 1997
    ..The pattern of chemokine gene expression in LCM may profoundly influence the characteristic phenotype and response of leukocytes in the brain and contribute to the immunopathogenesis of this fatal CNS infection...
  23. pmc Blocking chemokine responsive to gamma-2/interferon (IFN)-gamma inducible protein and monokine induced by IFN-gamma activity in vivo reduces the pathogenetic but not the antiviral potential of hepatitis B virus-specific cytotoxic T lymphocytes
    K Kakimi
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 194:1755-66. 2001
    ....
  24. pmc Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain
    C J Heyser
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 94:1500-5. 1997
    ..They suggest a critical role for a proinflammatory cytokine in the cognitive deficits and associated neuroinflammatory changes that have been documented in neurodegenerative diseases such as Alzheimer disease and AIDS...
  25. ncbi request reprint Site-specific hippocampal pathophysiology due to cerebral overexpression of interleukin-6 in transgenic mice
    S C Steffensen
    Department of Neuropharmacology CVN 13, Scripps Research Institute, La Jolla, CA 92037
    Brain Res 652:149-53. 1994
    ..These results indicate that overexpression of interleukin-6 selectively disrupts cholinergic transmission by inducing a functional pathophysiology of hippocampal cholinoceptive target neurons...
  26. ncbi request reprint Altered tissue distribution of viral replication and T cell spreading is pivotal in the protection against fatal lymphocytic choriomeningitis in mice after neutralization of IFN-alpha/beta
    K Sandberg
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, CA 92037
    J Immunol 153:220-31. 1994
    ..Absence of IFN-alpha/beta expression in the central nervous system is proposed as the mechanism behind the IFN-alpha/beta-dependent targeting of T cells to the brain...
  27. ncbi request reprint Islet-specific Th1, but not Th2, cells secrete multiple chemokines and promote rapid induction of autoimmune diabetes
    L M Bradley
    Departments ofImmunology and Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 162:2511-20. 1999
    ....
  28. ncbi request reprint Simultaneous analysis of multiple cytokine receptor mRNAs by RNase protection assay in LPS-induced endotoxemia
    A K Stalder
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, CA 92037
    Lymphokine Cytokine Res 13:107-12. 1994
    ..This technique will prove valuable in further evaluating the coordinated regulation of the expression of these genes, which are pivotal in the biology of cytokines.(ABSTRACT TRUNCATED AT 250 WORDS)..
  29. ncbi request reprint Inducible production of interferon-gamma in the developing brain causes cerebellar dysplasia with activation of the Sonic hedgehog pathway
    Jianping Wang
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Mol Cell Neurosci 27:489-96. 2004
    ..We conclude that IFN-gamma directly affects the proliferation and fate of EGL neurons in the cerebellum by activating the Shh pathway and stimulating an autocrine growth response by these cells...
  30. ncbi request reprint Interferon-gamma induced medulloblastoma in the developing cerebellum
    Wensheng Lin
    Jack Miller Center for Peripheral Neuropathy, Department of Neurology, University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 24:10074-83. 2004
    ..Thus, IFN-gamma expression in the perinatal period can induce SHH expression and medulloblastoma in the cerebellum by a STAT1-dependent mechanism, and its continued presence appears to promote a host response to the tumor...
  31. ncbi request reprint Deletion of the complement anaphylatoxin C3a receptor attenuates, whereas ectopic expression of C3a in the brain exacerbates, experimental autoimmune encephalomyelitis
    Laura Boos
    Department of Microbiology, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 173:4708-14. 2004
    ..These studies indicate that C3a may contribute to the pathogenesis of demyelinating disease by directly or indirectly chemoattracting encephalitogenic cells to the CNS...
  32. pmc MMPs are required for recruitment of antigen-nonspecific mononuclear cells into the liver by CTLs
    Giovanni Sitia
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Clin Invest 113:1158-67. 2004
    ....
  33. ncbi request reprint Acute exposure to CXC chemokine ligand 10, but not its chronic astroglial production, alters synaptic plasticity in mouse hippocampal slices
    Roman Vlkolinsky
    Department of Neuropharmacology, CVN 12, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Neuroimmunol 150:37-47. 2004
    ..The effect was probably receptor-mediated because CXCL10-induced inhibition of LTP was not observed in CXCR3 KO mice. Our findings suggest that acute exposure to CXCL10 alters synaptic plasticity via CXCR3 in mouse hippocampus...
  34. ncbi request reprint The role of advanced glycation end products in retinal microvascular leukostasis
    Tara C B Moore
    Department of Ophthalmology, Royal Victoria Hospital, The Queen s University of Belfast, Northern Ireland
    Invest Ophthalmol Vis Sci 44:4457-64. 2003
    ....
  35. pmc Dysregulated Sonic hedgehog signaling and medulloblastoma consequent to IFN-alpha-stimulated STAT2-independent production of IFN-gamma in the brain
    Jianping Wang
    The Scripps Research Institute, SP315, 10550 N Torrey Pines Road, La Jolla, California 92037, USA
    J Clin Invest 112:535-43. 2003
    ..Moreover, a hitherto unknown role is indicated for the immune system in the pathogenesis of developmental disorders and tumorigenesis of the CNS via dysregulated Shh signaling mediated by IFN-gamma...
  36. ncbi request reprint Astrocyte-targeted expression of interleukin-6 protects the central nervous system during neuroglial degeneration induced by 6-aminonicotinamide
    Milena Penkowa
    Department of Medical Anatomy, The Panum Institute, University of Copenhagen, Copenhagen, Denmark
    J Neurosci Res 73:481-96. 2003
    ..MT-I+II are antioxidants and neuroregenerative factors in the CNS, so increased MT-I+II levels in GFAP-IL6 mice could contribute to the reduction of oxidative stress and cell death in these mice...
  37. ncbi request reprint Diverging mechanisms for TNF-alpha receptors in normal mouse brains and in functional recovery after injury: From gene to behavior
    Albert Quintana
    Institute of Neurosciences and Department of Cellular Biology, Physiology and Immunology, Animal Physiology Unit, Faculty of Sciences, Autonomous University of Barcelona, Bellaterra, Spain
    J Neurosci Res 85:2668-85. 2007
    ....
  38. pmc Differential regulation of interferon regulatory factor (IRF)-7 and IRF-9 gene expression in the central nervous system during viral infection
    Shalina S Ousman
    School of Molecular and Microbial Biosciences, G08 Maze Crescent, University of Sydney, New South Wales 2006, Australia
    J Virol 79:7514-27. 2005
    ....
  39. pmc Increased expression of the beta4 and alpha5 integrin subunits in cerebral blood vessels of transgenic mice chronically producing the pro-inflammatory cytokines IL-6 or IFN-alpha in the central nervous system
    Richard Milner
    Department of Molecular and Experimental Medicine, MEM 132, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Cell Neurosci 33:429-40. 2006
    ..We propose that during neuroinflammation, astrocytes attempt to increase adhesive interactions at the blood-brain barrier (BBB), in order to increase barrier integrity...
  40. ncbi request reprint Analysis of the cerebral transcriptome in mice subjected to traumatic brain injury: importance of IL-6
    Albert Quintana
    Institute of Neurosciences and Department of Cellular Biology, Physiology and Immunology, Animal Physiology Unit, Faculty of Sciences, Autonomous University of Barcelona, Bellaterra, Spain
    Neuroimmunomodulation 14:139-43. 2007
    ..With this approach, we have demonstrated that a cytokine such as interleukin-6 is one of the key players in the response of the brain to injury...
  41. ncbi request reprint Minimal role for STAT1 in interleukin-6 signaling and actions in the murine brain
    Elisenda Sanz
    Department of Biochemistry and Molecular Biology, The Autonomous University of Barcelona, Barcelona, Spain
    Glia 56:190-9. 2008
    ..In conclusion, although IL-6 can activate STAT1 this plays minimal, if any, role in IL-6 signaling and actions in the CNS...
  42. ncbi request reprint Effect of astrocyte-targeted production of IL-6 on traumatic brain injury and its impact on the cortical transcriptome
    Albert Quintana
    Institute of Neurosciences and Department of Cellular Biology, Physiology and Immunology, Animal Physiology Unit, Faculty of Sciences, Autonomous University of Barcelona, Bellaterra, Barcelona, Spain
    Dev Neurobiol 68:195-208. 2008
    ....
  43. ncbi request reprint Induction of the genes for Cxcl9 and Cxcl10 is dependent on IFN-gamma but shows differential cellular expression in experimental autoimmune encephalomyelitis and by astrocytes and microglia in vitro
    Sally L Carter
    School of Molecular and Microbial Biosciences, The University of Sydney, NSW, Australia
    Glia 55:1728-39. 2007
    ..The differential glial localization of these chemokines in EAE suggests CXCL9 and CXCL10 have specialized functions...
  44. ncbi request reprint Role of IFN-gamma in an experimental murine model of West Nile virus-induced seizures
    Daniel R Getts
    The Discipline of Pathology, The University of Sydney, Sydney, New South Wales, Australia
    J Neurochem 103:1019-30. 2007
    ..Our data show that IFN-gamma plays an important role in the development of the excitatory seizure pathways in the brain and that these cascades become pathogenic in encephalitic WNV infection...
  45. ncbi request reprint CXCR3 signaling reduces the severity of experimental autoimmune encephalomyelitis by controlling the parenchymal distribution of effector and regulatory T cells in the central nervous system
    Marcus Müller
    School of Molecular and Microbial Biosciences, School of Medical Sciences, University of Sydney, Sydney, Australia
    J Immunol 179:2774-86. 2007
    ..We conclude that in EAE, CXCR3 signaling constrains T cells to the perivascular space in the CNS and augments regulatory T cell recruitment and effector T cell interaction, thus limiting autoimmune-mediated tissue damage...
  46. pmc Persistent macrophage/microglial activation and myelin disruption after experimental autoimmune encephalomyelitis in tissue inhibitor of metalloproteinase-1-deficient mice
    Stephen J Crocker
    The Molecular and Integrative Neurosciences Department, The Scripps Research Institute, SP30 2110, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Am J Pathol 169:2104-16. 2006
    ....
  47. pmc Coordinated regulation and widespread cellular expression of interferon-stimulated genes (ISG) ISG-49, ISG-54, and ISG-56 in the central nervous system after infection with distinct viruses
    Christie Wacher
    School of Molecular and Microbial Biosciences, University of Sydney, Sydney, NSW 2006, Australia
    J Virol 81:860-71. 2007
    ..These findings suggest a dominant role for the ISG-49, ISG-54, and ISG-56 genes in the host response to different viruses in the central nervous system, where, particularly in neurons, these genes may have nonredundant functions...
  48. ncbi request reprint Profound increase in sensitivity to glutamatergic- but not cholinergic agonist-induced seizures in transgenic mice with astrocyte production of IL-6
    Helen Samland
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci Res 73:176-87. 2003
    ....
  49. ncbi request reprint Astrocyte-targeted expression of IL-6 protects the CNS against a focal brain injury
    Milena Penkowa
    Department of Medical Anatomy, The Panum Institute, University of Copenhagen, Denmark
    Exp Neurol 181:130-48. 2003
    ....
  50. ncbi request reprint Unforeseen consequences of IL-12 expression in the eye of GFAP-IL12 transgenic mice following herpes simplex virus type 1 infection
    Daniel J J Carr
    Department of Ophthalmology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    DNA Cell Biol 21:467-73. 2002
    ....
  51. ncbi request reprint Leukocyte infiltration, but not neurodegeneration, in the CNS of transgenic mice with astrocyte production of the CXC chemokine ligand 10
    Kaan Boztug
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 169:1505-15. 2002
    ..Finally, the accumulation of neutrophils in the brain of GF-CXCL10 transgenic mice is apparently independent of CXCR3 and involves an unknown mechanism...
  52. ncbi request reprint The integrin family of cell adhesion molecules has multiple functions within the CNS
    Richard Milner
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci Res 69:286-91. 2002
    ..This review will focus on recently emerging evidence of novel and diverse roles of integrins and their ligands in the CNS during development and in the adult, in health and disease...
  53. ncbi request reprint Metallothionein-1+2 deficiency increases brain pathology in transgenic mice with astrocyte-targeted expression of interleukin 6
    Mercedes Giralt
    Instituto de Neurociencías and Departamento de Biologia Celular, de Fisiología y de Immunología, Unidad de Fisiologia Animal, Facultad de Ciencias, Universidad Autonoma de Barcelona, Bellaterra, Spain
    Neurobiol Dis 9:319-38. 2002
    ..Overall, the results suggest that the MT-1+2 proteins are valuable factors against cytokine-induced CNS injury...
  54. ncbi request reprint The inflammatory milieu associated with conjunctivalized cornea and its alteration with IL-1 RA gene therapy
    Jonathan E Moore
    Department of Ophthalmology, Royal Victoria Hospital, The Queen s University of Belfast, Belfast, Northern Ireland, United Kingdom
    Invest Ophthalmol Vis Sci 43:2905-15. 2002
    ..The objective of this study was to modulate this environment by gene therapy with the anti-inflammatory cytokine interleukin-1 receptor antagonist (IL-1 RA)...
  55. ncbi request reprint Developmental regulation of beta1 integrins during angiogenesis in the central nervous system
    Richard Milner
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    Mol Cell Neurosci 20:616-26. 2002
    ..Furthermore, it suggests that regulation of beta1 integrin and ECM expression by endothelial cells are important factors influencing vascular development in the CNS...
  56. ncbi request reprint Chemokines are differentially expressed by astrocytes, microglia and inflammatory leukocytes in Toxoplasma encephalitis and critically regulated by interferon-gamma
    Andreas Strack
    Abteilung für Neuropathologie, Universitat zu Koln, Joseph Stelzmann Str 9, 50931 Koln, Germany
    Acta Neuropathol 103:458-68. 2002
    ..Since T cells are the single source of IFN-gamma in TE, these findings indicate that T cells pave the way of leukocytes to parenchymatous parasites via IFN-gamma...
  57. pmc Borna disease virus accelerates inflammation and disease associated with transgenic expression of interleukin-12 in the central nervous system
    Susanna Freude
    Abteilung Neuropathologie, Pathologisches Institut, Universitat Freiburg, D 79106 Freiburg, Germany
    J Virol 76:12223-32. 2002
    ..Our results illustrate that infection of the CNS with a virus that is benign in certain hosts can be harmful in such normally disease-resistant hosts if the tissue is unfavorably preconditioned by proinflammatory cytokines...
  58. ncbi request reprint Resistance to ocular herpes simplex virus type 1 infection in IL-12 transgenic mice
    Khaldun Al-Khatib
    Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Neuroimmunol 132:41-8. 2002
    ..Collectively, the data show the inherent resistance of mice constitutively expressing IL-12 to ocular HSV-1 infection-an outcome that is independent of the adaptive immune system at the time of infection...
  59. ncbi request reprint Regulation of the kinetics of intracerebral chemokine gene expression in murine Toxoplasma encephalitis: impact of host genetic factors
    Andreas Strack
    Abteilung für Neuropathologie, Klinikum der Universität zu Köln, Koln, Germany
    Glia 40:372-7. 2002
    ..Thus, the present study demonstrates that host genetic factors exert a strong impact on i.c. chemokines in experimental murine TE...
  60. pmc STAT1 deficiency unexpectedly and markedly exacerbates the pathophysiological actions of IFN-alpha in the central nervous system
    Jianping Wang
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:16209-14. 2002
    ..Finally, STAT1 or a downstream component of the JAKSTAT pathway may protect against such IFN-alpha-mediated injury in the CNS...
  61. ncbi request reprint Disruption of the C5a receptor gene fails to protect against experimental allergic encephalomyelitis
    Rachael Reiman
    Department of Microbiology, University of Alabama at Birmingham, Birmingham 35294, USA
    Eur J Immunol 32:1157-63. 2002
    ..These results indicate that the C5aR is not an essential mediator in the induction and progression of EAE...
  62. ncbi request reprint Cytokines regulate microglial adhesion to laminin and astrocyte extracellular matrix via protein kinase C-dependent activation of the alpha6beta1 integrin
    Richard Milner
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 22:1562-72. 2002
    ....
  63. pmc Regulation of signal transducer and activator of transcription and suppressor of cytokine-signaling gene expression in the brain of mice with astrocyte-targeted production of interleukin-12 or experimental autoimmune encephalomyelitis
    Joachim Maier
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    Am J Pathol 160:271-88. 2002
    ....
  64. ncbi request reprint Reduced hippocampal neurogenesis in adult transgenic mice with chronic astrocytic production of interleukin-6
    Luc Vallières
    Laboratories of Neuronal Structure and Function, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 22:486-92. 2002
    ..These findings suggest that long-term exposure of the brain to proinflammatory mediators such as IL-6, as is seen in certain degenerative disorders and infections, can interfere with adult neurogenesis...
  65. ncbi request reprint Metallothionein-I overexpression decreases brain pathology in transgenic mice with astrocyte-targeted expression of interleukin-6
    Amalia Molinero
    Institute of Neurosciences and Department of Cellular Biology, Physiology and Immunology, Autonomous University of Barcelona, Bellaterra, Barcelona, Spain
    J Neuropathol Exp Neurol 62:315-28. 2003
    ..Interestingly, MT-I overexpression increased angiogenesis in GFAP-IL6 mice but not in control littermates. Overall, the results strongly suggest that MT-I+II proteins are valuable factors that protect against cytokine-induced CNS injury...
  66. ncbi request reprint Metallothionein-I overexpression alters brain inflammation and stimulates brain repair in transgenic mice with astrocyte-targeted interleukin-6 expression
    Milena Penkowa
    Department of Medical Anatomy, Panum Institute, University of Copenhagen, Copenhagen, Denmark
    Glia 42:287-306. 2003
    ..Overall, the results demonstrate that brain MT-I+II proteins are fundamental neuroprotective factors...
  67. ncbi request reprint The extracellular matrix and cytokines regulate microglial integrin expression and activation
    Richard Milner
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 170:3850-8. 2003
    ....
  68. ncbi request reprint Tumor necrosis factor-alpha inhibits seizures in mice via p75 receptors
    Silvia Balosso
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milano, Italy
    Ann Neurol 57:804-12. 2005
    ..This evidence highlights a novel function of TNF-alpha in brain and indicates a new system for anticonvulsive intervention...
  69. pmc Herpes simplex virus type 1 induction of chemokine production is unrelated to viral load in the cornea but not in the nervous system
    Daniel J J Carr
    Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Viral Immunol 19:741-6. 2006
    ..We interpret these results as suggesting chemokine expression within the cornea in response to herpes simplex virus type 1 infection is driven by factors other than antigenic stimulation...
  70. ncbi request reprint IFN-gamma-induced chemokines synergize with pertussis toxin to promote T cell entry to the central nervous system
    Jason M Millward
    Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    J Immunol 178:8175-82. 2007
    ....
  71. ncbi request reprint Role of metallothionein-III following central nervous system damage
    Javier Carrasco
    Institute of Neurosciences and Department of Cellular Biology, Physiology and Immunology, Animal Physiology Unit, Faculty of Sciences, Autonomous University of Barcelona, Bellaterra, Barcelona, Spain 08193
    Neurobiol Dis 13:22-36. 2003
    ....
  72. ncbi request reprint Cell and agonist-specific regulation of genes for matrix metalloproteinases and their tissue inhibitors by primary glial cells
    Stephen J Crocker
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California, USA
    J Neurochem 98:812-23. 2006
    ....
  73. pmc The stromal cell-derived factor-1alpha/CXCR4 ligand-receptor axis is critical for progenitor survival and migration in the pancreas
    Ayse G Kayali
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Biol 163:859-69. 2003
    ..Together, these data indicate that the SDF-1alpha-CXCR4 ligand receptor axis is an obligatory component in the maintenance of duct cell survival, proliferation, and migration during pancreatic regeneration...
  74. ncbi request reprint The TIMPs tango with MMPs and more in the central nervous system
    Stephen J Crocker
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci Res 75:1-11. 2004
    ....
  75. ncbi request reprint Physiological and behavioral effects of methamphetamine in a mouse model of endotoxemia: a preliminary study
    Manuel Sanchez-Alavez
    Department of Neuropharmacology, The Scripps Research Institute, CVN 13, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Pharmacol Biochem Behav 77:365-70. 2004
    ..These findings suggest that induction of peripheral endotoxemia in animals with a history of METH reduced the hyperthermic response to a subsequent challenge with METH...
  76. pmc T cells infiltrate the brain in murine and human transmissible spongiform encephalopathies
    Hanna Lewicki
    Division of Virology, Department of Neuropharmacology IMM 6, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 77:3799-808. 2003
    ..However, these CD4 and CD8 T cells are defective in such an effector function(s) as IFN-gamma and TNF-alpha expression or release or lytic activity...
  77. ncbi request reprint Cytokine-mediated inflammation, tumorigenesis, and disease-associated JAK/STAT/SOCS signaling circuits in the CNS
    Iain L Campbell
    School of Molecular and Microbial Biosciences, The University of Sydney, NSW, Australia
    Brain Res Brain Res Rev 48:166-77. 2005
    ..The cellular compartmentalization and balance in the activity of these pathways ultimately determines the repertoire and nature of CNS cytokine actions...
  78. pmc Innate STAT1-dependent genomic response of neurons to the antiviral cytokine alpha interferon
    Jianping Wang
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, Califonia 92037, USA
    J Virol 79:8295-302. 2005
    ..In conclusion, our study revealed a robust STAT1-dependent genomic response of neurons to IFN-alpha, highlighting an innate potential of these cells to defend against viral infection in the brain...
  79. pmc RNA-dependent protein kinase is required for alpha-1 interferon transgene-induced resistance to genital herpes simplex virus type 2
    Daniel J J Carr
    Department of Ophthalmology, DMEI 415, The University of Oklahoma Health Sciences Center, 608 Stanton L Young Blvd, Oklahoma City, OK 73104, USA
    J Virol 79:9341-5. 2005
    ....
  80. ncbi request reprint Regulation of murine interferon regulatory factor gene expression in the central nervous system determined by multiprobe RNase protection assay
    Shalina S Ousman
    Department of Neurology and Neurological Sciences, Stanford University, CT, USA
    Methods Mol Med 116:115-34. 2005
    ..Here, we describe the development of a multiprobe RNase protection assay that permits the simultaneous detection and quantification of IRF ribonucleic acid transcripts for multiple family members in murine cells and tissues...
  81. ncbi request reprint Expression of C5a in the brain does not exacerbate experimental autoimmune encephalomyelitis
    Rachael Reiman
    Department of Microbiology, University of Alabama at Birmingham, 845 19th St S, Birmingham, AL 35294, USA
    Neurosci Lett 390:134-8. 2005
    ..These results demonstrate that C5a, despite it is pro-inflammatory functions, is not critical to the development and progression of EAE...
  82. ncbi request reprint Differential role of tumor necrosis factor receptors in mouse brain inflammatory responses in cryolesion brain injury
    Albert Quintana
    Institute of Neurosciences and Department of Cellular Biology, Physiology and Immunology, Animal Physiology Unit, Faculty of Sciences, Autonomous University of Barcelona, Bellaterra, Barcelona, Spain
    J Neurosci Res 82:701-16. 2005
    ..Overall, these results suggest that TNFR1 is involved in the early establishment of the inflammatory response and that its deficiency causes a decreased inflammatory response and tissue damage following brain injury...
  83. pmc Ly6c+ "inflammatory monocytes" are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis
    Daniel R Getts
    The Discipline of Pathology, School of Medical Sciences, The University of Sydney, Sydney NSW 2006, Australia
    J Exp Med 205:2319-37. 2008
    ..Therefore, CCL2-dependent inflammatory monocyte migration is critical for increases in microglia during WNV infection and may also play a pathogenic role during WNV encephalitis...