- Kishore N, Huynh Q, Mathialagan S, Hall T, Rouw S, Creely D, et al. IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2. J Biol Chem. 2002;277:13840-7 pubmed..Thus, although these IKKs are structurally similar, their enzymatic properties may provide insights into their unique functions. ..