Sanjiv Kaul

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. doi request reprint What is coronary blood flow reserve? Insights using myocardial contrast echocardiography
    Sanjiv Kaul
    Cardiovascular Division, UHN 62, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR, 97239, USA
    J Echocardiogr 10:1-7. 2012
  2. doi request reprint The "no reflow" phenomenon following acute myocardial infarction: mechanisms and treatment options
    Sanjiv Kaul
    Knight Cardiovascular Institute UHN 62, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA Electronic address
    J Cardiol 64:77-85. 2014
  3. pmc Dual-energy X-ray absorptiometry for quantification of visceral fat
    Sanjiv Kaul
    Cardiovascular Medicine Division, Oregon Health and Science University, Portland, Oregon, USA
    Obesity (Silver Spring) 20:1313-8. 2012
  4. doi request reprint Myocardial contrast echocardiography: a 25-year retrospective
    Sanjiv Kaul
    Division of Cardiovascular Medicine, Oregon Health and Science University, UHN62, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
    Circulation 118:291-308. 2008
  5. pmc Effect of modest alcohol consumption over 1-2 weeks on the coronary microcirculation of normal subjects
    Sanjiv Kaul
    Cardiovascular Medicine Division, UHN 62, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Eur J Echocardiogr 11:683-9. 2010
  6. ncbi request reprint Evaluating the 'no reflow' phenomenon with myocardial contrast echocardiography
    Sanjiv Kaul
    Division of Cardiovascular Medicine, Oregon Health and Sciences University, UHN62, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Basic Res Cardiol 101:391-9. 2006
  7. ncbi request reprint Myocardial contrast echocardiography versus Thrombolysis In Myocardial Infarction score in patients presenting to the emergency department with chest pain and a nondiagnostic electrocardiogram
    Khim Leng Tong
    Cardiovascular Imaging Center, Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, Virginia, USA
    J Am Coll Cardiol 46:920-7. 2005
  8. ncbi request reprint Myocardial and microcirculatory kinetics of BR14, a novel third-generation intravenous ultrasound contrast agent
    Nicholas G Fisher
    Cardiovascular Imaging Center, Cardiovascular Division, University of Virginia, Charlottesville, Virginia 22908, USA
    J Am Coll Cardiol 39:530-7. 2002
  9. ncbi request reprint Effects of nitroglycerin on erythrocyte rheology and oxygen unloading: novel role of S-nitrosohemoglobin in relieving myocardial ischemia
    Jian Ping Bin
    Division of Cardiovascular Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
    Circulation 113:2502-8. 2006
  10. ncbi request reprint Measurement of myocardial blood flow velocity reserve with myocardial contrast echocardiography in patients with suspected coronary artery disease: comparison with quantitative gated Technetium 99m sestamibi single photon emission computed tomography
    Dana Dawson
    Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, Virgina 22908 0158, USA
    J Am Soc Echocardiogr 16:1171-7. 2003

Research Grants

Collaborators

Detail Information

Publications76

  1. doi request reprint What is coronary blood flow reserve? Insights using myocardial contrast echocardiography
    Sanjiv Kaul
    Cardiovascular Division, UHN 62, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR, 97239, USA
    J Echocardiogr 10:1-7. 2012
    ..The insights offered by myocardial contrast echocardiography are unique and novel, and highlight the importance of the myocardial capillaries in determining coronary blood flow reserve in health and disease. ..
  2. doi request reprint The "no reflow" phenomenon following acute myocardial infarction: mechanisms and treatment options
    Sanjiv Kaul
    Knight Cardiovascular Institute UHN 62, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA Electronic address
    J Cardiol 64:77-85. 2014
    ....
  3. pmc Dual-energy X-ray absorptiometry for quantification of visceral fat
    Sanjiv Kaul
    Cardiovascular Medicine Division, Oregon Health and Science University, Portland, Oregon, USA
    Obesity (Silver Spring) 20:1313-8. 2012
    ..This simple noninvasive method with virtually no radiation can therefore be used to measure VF in individual patients and help define diabetes and cardiovascular risk...
  4. doi request reprint Myocardial contrast echocardiography: a 25-year retrospective
    Sanjiv Kaul
    Division of Cardiovascular Medicine, Oregon Health and Science University, UHN62, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
    Circulation 118:291-308. 2008
  5. pmc Effect of modest alcohol consumption over 1-2 weeks on the coronary microcirculation of normal subjects
    Sanjiv Kaul
    Cardiovascular Medicine Division, UHN 62, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Eur J Echocardiogr 11:683-9. 2010
    ..Since alcohol intake is unlikely to acutely change capillary dimensions, we hypothesized that it must increase coronary blood flow reserve by reducing whole-blood viscosity...
  6. ncbi request reprint Evaluating the 'no reflow' phenomenon with myocardial contrast echocardiography
    Sanjiv Kaul
    Division of Cardiovascular Medicine, Oregon Health and Sciences University, UHN62, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Basic Res Cardiol 101:391-9. 2006
    ..This paper will cover these areas briefly...
  7. ncbi request reprint Myocardial contrast echocardiography versus Thrombolysis In Myocardial Infarction score in patients presenting to the emergency department with chest pain and a nondiagnostic electrocardiogram
    Khim Leng Tong
    Cardiovascular Imaging Center, Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, Virginia, USA
    J Am Coll Cardiol 46:920-7. 2005
    ....
  8. ncbi request reprint Myocardial and microcirculatory kinetics of BR14, a novel third-generation intravenous ultrasound contrast agent
    Nicholas G Fisher
    Cardiovascular Imaging Center, Cardiovascular Division, University of Virginia, Charlottesville, Virginia 22908, USA
    J Am Coll Cardiol 39:530-7. 2002
    ..This study sought to investigate the myocardial and microvascular kinetics of BR14, a novel third-generation ultrasound contrast agent...
  9. ncbi request reprint Effects of nitroglycerin on erythrocyte rheology and oxygen unloading: novel role of S-nitrosohemoglobin in relieving myocardial ischemia
    Jian Ping Bin
    Division of Cardiovascular Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
    Circulation 113:2502-8. 2006
    ..We hypothesized that nitroglycerin improves O2 delivery to ischemic tissue by altering erythrocyte rheology and O2 unloading through an increase in bioactive nitric oxide (NO) content...
  10. ncbi request reprint Measurement of myocardial blood flow velocity reserve with myocardial contrast echocardiography in patients with suspected coronary artery disease: comparison with quantitative gated Technetium 99m sestamibi single photon emission computed tomography
    Dana Dawson
    Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, Virgina 22908 0158, USA
    J Am Soc Echocardiogr 16:1171-7. 2003
    ....
  11. ncbi request reprint Detection of coronary stenoses at rest with myocardial contrast echocardiography
    Kevin Wei
    Cardiovascular Imaging Center, Cardiovascular Division, Department of Medicine, University of Virginia, Charlottesville, VA, USA
    Circulation 112:1154-60. 2005
    ....
  12. ncbi request reprint Cyclic variation in ultrasonic myocardial integrated backscatter is due to phasic changes in the number of patent myocardial microvessels
    Antonio Micari
    Division of Cardiovascular Medicine, Oregon Health and Science University, Portland, OR 97239, USA
    J Ultrasound Med 25:1009-19. 2006
    ..We tested the hypothesis that the cyclic variation in ultrasonic myocardial integrated backscatter (IBS) is due to cardiac contraction-induced changes in the number of patent myocardial microvessels...
  13. ncbi request reprint Regional left ventricular perfusion and function in patients presenting to the emergency department with chest pain and no ST-segment elevation
    Diana Rinkevich
    The Cardiovascular Imaging Center, Cardiovascular Division, University of Virginia, Medical Center, Charlottesville, VA 22908 0158, USA
    Eur Heart J 26:1606-11. 2005
    ....
  14. ncbi request reprint Automated quantification of the spatial extent of perfusion defects and viability on myocardial contrast echocardiography
    Antonio Micari
    Cardiovascular Division, University of Virginia, Charlottesville, USA
    J Am Soc Echocardiogr 19:379-85. 2006
    ..This technique may be useful for rapid and objective analysis of the extent of ischemia and viability, and for clinical experimentation where accurate and sequential analysis of perfusion defect size is imperative...
  15. ncbi request reprint Improvement in microvascular reflow and reduction of infarct size with adenosine in patients undergoing primary coronary stenting
    Antonio Micari
    Cardiovascular Imaging Center, Cardiovascular Division, University of Virginia, Charlottesville, VA, USA
    Am J Cardiol 96:1410-5. 2005
    ..In conclusion, the adjunctive use of intravenous adenosine after PCS reduces the infarct size relative to the risk area. This beneficial effect occurs primarily in those undergoing early intervention...
  16. pmc Phasic changes in arterial blood volume is influenced by collateral blood flow: implications for the quantification of coronary stenosis at rest
    Marco Pascotto
    Division of Cardiovascular Medicine, Oregon Health and Science University, Portland, OR 97239, USA
    Heart 93:438-43. 2007
    ..There are some patients with moderate to severe coronary stenosis who nonetheless exhibit a normal systolic to disatolic aBV ratio...
  17. pmc A predictive instrument using contrast echocardiography in patients presenting to the emergency department with chest pain and without ST-segment elevation
    Kevin Wei
    Division of Cardiovascular Medicine and Biostatistics, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Am Soc Echocardiogr 23:636-42. 2010
    ..We hypothesized that in these patients a risk score incorporating clinical, ECG, and myocardial contrast echocardiography (MCE) variables would accurately predict adverse events occurring within the next 48 hours...
  18. ncbi request reprint Myocardial contrast echocardiography
    Wolfgang Lepper
    Cardiovascular Imaging Center, Cardiovascular Division, University of Virginia, Charlottesville, VA 22908 0158, USA
    Circulation 109:3132-5. 2004
  19. ncbi request reprint Effect of microbubble exposure to ultrasound on quantitation of myocardial perfusion
    Howard Leong-Poi
    Cardiovascular Imaging Center, Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Echocardiography 22:503-9. 2005
    ....
  20. ncbi request reprint Relation between myocardial oxygen consumption and myocardial blood volume: a study using myocardial contrast echocardiography
    D Elizabeth Le
    Cardiovascular Imaging Center, Cardiovascular Division, School of Medicine, University of Virginia Medical Center, Charlottesville, VA 22908, USA
    J Am Soc Echocardiogr 15:857-63. 2002
    ..Thus, capillary recruitment plays an important role in the physiologic regulation of CBF. Lack of increase in MBV during dobutamine stress may indicate the presence of coronary stenosis or microvascular disease...
  21. pmc Limb stress-rest perfusion imaging with contrast ultrasound for the assessment of peripheral arterial disease severity
    Jonathan R Lindner
    Cardiovascular Division, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    JACC Cardiovasc Imaging 1:343-50. 2008
    ..We hypothesized that stress-rest perfusion imaging of skeletal muscle in the lower extremity with contrast-enhanced ultrasound (CEU) could evaluate the severity of peripheral arterial disease (PAD)...
  22. ncbi request reprint Assessment of ischemia-induced microvascular remodeling using contrast-enhanced ultrasound vascular anatomic mapping
    Marco Pascotto
    Cardiovascular Division, University of Virginia, Charlottesville, Virginia, USA
    J Am Soc Echocardiogr 20:1100-8. 2007
    ..We conclude that CEU can separately assess collateral development, more distal arteriogenesis, and secondary changes in capillary perfusion that occur differentially with ischemia and growth factor therapy...
  23. ncbi request reprint Role of collateral blood flow in the apparent disparity between the extent of abnormal wall thickening and perfusion defect size during acute myocardial infarction and demand ischemia
    Howard Leong-Poi
    Cardiovascular Imaging Center, Cardiovascular Division, University of Virginia, Charlottesville 22908 0158, USA
    J Am Coll Cardiol 45:565-72. 2005
    ....
  24. ncbi request reprint Effect of time delay on the diagnostic use of contrast echocardiography in patients presenting to the emergency department with chest pain and no S-T segment elevation
    Saul Kalvaitis
    Division of Cardiovascular Medicine, Oregon Health and Sciences University, Portland, Oregon 97239, USA
    J Am Soc Echocardiogr 19:1488-93. 2006
    ....
  25. pmc Prognostic value of dipyridamole stress myocardial contrast echocardiography: comparison with single photon emission computed tomography
    Dana Dawson
    Division of Cardiovascular Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Am Soc Echocardiogr 22:954-60. 2009
    ..Because blood flow mismatch precedes wall thickening (WT) abnormalities during demand ischemia, it was also postulated that perfusion on MCE would be superior to WT abnormalities on echocardiography for this purpose...
  26. ncbi request reprint Further insights into the no-reflow phenomenon after primary angioplasty in acute myocardial infarction: the role of microthromboemboli
    Tadamichi Sakuma
    Cardiovascular Imaging Center, Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Am Soc Echocardiogr 16:15-21. 2003
    ..No reflow late after reperfusion is a result of tissue necrosis. The thrombus burden also affects ultimate IS...
  27. doi request reprint Detection of coronary stenosis with myocardial contrast echocardiography using regadenoson, a selective adenosine A2A receptor agonist
    D Elizabeth Le
    Portland Veterans Affairs Medical Center, 3710 SW US Veterans Hospital Road, Portland, OR 97239, USA
    Eur Heart J Cardiovasc Imaging 13:298-308. 2012
    ..This study assessed the haemodynamic profile and ability of regadenoson, a novel selective A(2A) receptor agonist, to detect coronary artery stenosis during myocardial contrast echocardiography...
  28. pmc Anti-inflammatory and pro-angiogenic effects of beta blockers in a canine model of chronic ischemic cardiomyopathy: comparison between carvedilol and metoprolol
    D Elizabeth Le
    Hospital and Specialty Medicine Cardiology, Portland VA Medical Center and Knight Cardiovascular Institute, Portland, OR, USA
    Basic Res Cardiol 108:384. 2013
    ..Further studies are required for comparing additional doses of these drugs...
  29. ncbi request reprint Microvasculature in acute myocardial ischemia: part II: evolving concepts in pathophysiology, diagnosis, and treatment
    Sanjiv Kaul
    Cardiovascular Division, Box 800158, Medical Center, University of Virginia, Charlottesville, VA 22908 0158, USA
    Circulation 109:310-5. 2004
  30. pmc Coronary autoregulation is abnormal in syndrome X: insights using myocardial contrast echocardiography
    Diana Rinkevich
    Knight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Am Soc Echocardiogr 26:290-6. 2013
    ..The aim of this study was to characterize the microvascular site of dysfunction in these patients using myocardial contrast echocardiography...
  31. ncbi request reprint Molecular imaging identifies regions with microthromboemboli during primary angioplasty in acute coronary thrombosis
    Tadamichi Sakuma
    Cardiovascular Imaging Center and Experimental Cardiology Laboratory, Cardiovascular Division, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    J Nucl Med 45:1194-200. 2004
    ....
  32. ncbi request reprint Simultaneous integrin alphavbeta3 and glycoprotein IIb/IIIa inhibition causes reduction in infarct size in a model of acute coronary thrombosis and primary angioplasty
    Tadamichi Sakuma
    Cardiovascular Division, Medical Center, University of Virginia, Charlottesville, 22908 0158, USA
    Cardiovasc Res 66:552-61. 2005
    ....
  33. pmc Cost-efficiency of myocardial contrast echocardiography in patients presenting to the emergency department with chest pain of suspected cardiac origin and a nondiagnostic electrocardiogram
    Jared J Wyrick
    Cardiovascular Division and Department of Emergency Medicine, Oregon Health and Science University, Portland, Oregon, USA
    Am J Cardiol 102:649-52. 2008
    ....
  34. doi request reprint Molecular imaging of endothelial vascular cell adhesion molecule-1 expression and inflammatory cell recruitment during vasculogenesis and ischemia-mediated arteriogenesis
    Carolyn Z Behm
    Division of Cardiovascular Medicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
    Circulation 117:2902-11. 2008
    ..We hypothesized that inflammatory cell recruitment and endothelial cell activation during vasculogenesis and ischemia-mediated arteriogenesis could be temporally assessed by noninvasive molecular imaging...
  35. ncbi request reprint The coronary microcirculation in health and disease
    Kevin Wei
    Cardiovascular Imaging Center, Cardiovascular Division, University of Virginia School of Medicine, Box 800158, Charlottesville, VA 22908 0158, USA
    Cardiol Clin 22:221-31. 2004
    ..MBV also responds to changes in myocardial oxygen demand. Because MCE can be used to assess MBF and MBV in vivo, it can be used to provide unique insights into tissue perfusion...
  36. ncbi request reprint Incremental value of cardiac imaging in patients presenting to the emergency department with chest pain and without ST-segment elevation: a multicenter study
    Sanjiv Kaul
    Cardiovascular Imaging Center, Cardiovascular Division, University of Virginia, Charlottesville, VA 22908 0158, USA
    Am Heart J 148:129-36. 2004
    ....
  37. ncbi request reprint Targeted tissue transfection with ultrasound destruction of plasmid-bearing cationic microbubbles
    Jonathan P Christiansen
    Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, VA, USA
    Ultrasound Med Biol 29:1759-67. 2003
    ....
  38. ncbi request reprint Influence of microbubble shell properties on ultrasound signal: Implications for low-power perfusion imaging
    Howard Leong-Poi
    Cardiovascular Imaging Center, Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, USA
    J Am Soc Echocardiogr 15:1269-76. 2002
    ..We conclude that the acoustic power for maximizing acoustic signal without destroying microbubbles during low mechanical index imaging varies according to shell characteristics...
  39. ncbi request reprint Influence of microbubble surface charge on capillary transit and myocardial contrast enhancement
    Nicholas G Fisher
    Cardiovascular Imaging Center, Cardiovascular Division, University of Virginia, Charlottesville, Virginia 22908 0158, USA
    J Am Coll Cardiol 40:811-9. 2002
    ..The goal of the study was to determine whether microbubble charge influences the microvascular retention of microbubble contrast agents...
  40. ncbi request reprint Perfusion versus function: the ischemic cascade in demand ischemia: implications of single-vessel versus multivessel stenosis
    Howard Leong-Poi
    Cardiac Imaging Center, Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, VA, USA
    Circulation 105:987-92. 2002
    ....
  41. ncbi request reprint Microvasculature in acute myocardial ischemia: part I: evolving concepts in pathophysiology, diagnosis, and treatment
    Sanjiv Kaul
    Cardiovascular Imaging Center, Cardiovascular Division, University of Virginia, Charlottesville, VA 22908 0158, USA
    Circulation 109:146-9. 2004
  42. ncbi request reprint Noninvasive assessment of angiogenesis by ultrasound and microbubbles targeted to alpha(v)-integrins
    Howard Leong-Poi
    Cardiovascular Imaging Center, Cardiovascular Division, University of Virginia, Charlottesville 22908, USA
    Circulation 107:455-60. 2003
    ..We hypothesized that angiogenesis could be imaged with the use of contrast-enhanced ultrasound (CEU) with microbubbles targeted to alpha(v)-integrins...
  43. ncbi request reprint Noninvasive imaging of myocardial reperfusion injury using leukocyte-targeted contrast echocardiography
    Jonathan P Christiansen
    Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, VA, USA
    Circulation 105:1764-7. 2002
    ..We hypothesized that myocardial contrast echocardiography (MCE) with leukocyte-targeted microbubbles could temporally and spatially characterize the severity of postischemic myocardial inflammation...
  44. ncbi request reprint Detection of coronary stenosis and myocardial viability using a single intravenous bolus injection of BR14
    Nicholas G Fisher
    Cardiovascular Imaging Center, Cardiovascular Division, University of Virginia, Charlottesville, Virginia 22908, USA
    J Am Coll Cardiol 39:523-9. 2002
    ..The aim of the study was to determine whether coronary stenosis can be detected and myocardial viability assessed after myocardial infarction from a single venous bolus injection of BR14, a new ultrasound contrast agent...
  45. pmc Temporal Changes in Skeletal Muscle Capillary Responses and Endothelial-Derived Vasodilators in Obesity-Related Insulin Resistance
    Scott M Chadderdon
    Knight Cardiovascular Institute, Oregon Health and Science University, Portland, OR
    Diabetes 65:2249-57. 2016
    ..The inability to sustain a vascular compensatory response limits glucose-mediated increases in CBV, which correlates with the severity of IR. ..
  46. doi request reprint Molecular imaging with contrast enhanced ultrasound
    Scott M Chadderdon
    Cardiovascular Division, UHN 62, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    J Nucl Cardiol 17:667-77. 2010
    ....
  47. ncbi request reprint Instrumentation for contrast echocardiography: technology and techniques
    Sanjiv Kaul
    Cardiovascular Imaging Center, Cardiovascular Division, University of Virginia School of Medicine, Charlottesville 22908, USA
    Am J Cardiol 90:8J-14J. 2002
    ..These signal-processing techniques have resulted in an increased signal-to-noise ratio from bubbles vis-à-vis the tissue and have made online assessment of myocardial perfusion possible...
  48. ncbi request reprint Vascular recruitment in skeletal muscle during exercise and hyperinsulinemia assessed by contrast ultrasound
    Dana Dawson
    Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Am J Physiol Endocrinol Metab 282:E714-20. 2002
    ..Exercise increases both V(RBC) and capBV, whereas hyperinsulinemia selectively increases only capBV, which may enhance skeletal muscle glucose uptake...
  49. ncbi request reprint Echocardiographic insights into regional flow-function relationships in coronary artery disease
    Sanjiv Kaul
    Cardiovascular Imaging Center, Cardiovascular Division, Box 800158 Medical Center, University of Virginia, Charlottesville, VA 22908 0158, USA
    J Nucl Cardiol 12:216-26. 2005
  50. ncbi request reprint Detection of noncritical coronary stenosis at rest without recourse to exercise or pharmacological stress
    Kevin Wei
    Cardiovascular Imaging Center, Cardiovascular Division, University of Virginia, Charlottesville, VA 22908, USA
    Circulation 105:218-23. 2002
    ..We hypothesized that these stenoses can be detected at rest without recourse to stress by assessing adaptive changes that occur distally in the microcirculation...
  51. doi request reprint Efficacy and spatial distribution of ultrasound-mediated clot lysis in the absence of thrombolytics
    Azzdine Y Ammi
    Azzdine Y Ammi, PhD, Knight Cardiovascular Institute, UHN 62, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA, Tel 1 503 494 8750, Fax 1 503 494 8550, E mail
    Thromb Haemost 113:1357-69. 2015
    ..25 MHz. The spatial location of sonothrombolysis varies with pressure and frequency indicating that the geometric relation between therapeutic probe and vascular thrombosis is an important variable for successful lysis clinically. ..
  52. doi request reprint Handheld ultrasound versus physical examination in patients referred for transthoracic echocardiography for a suspected cardiac condition
    Manish Mehta
    Knight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon
    JACC Cardiovasc Imaging 7:983-90. 2014
    ....
  53. pmc Ultrasound stimulates formation and release of vasoactive compounds in brain endothelial cells
    Catherine M Davis
    The Knight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon and Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, Oregon
    Am J Physiol Heart Circ Physiol 309:H583-91. 2015
    ..Such regulation supports a beneficial role for therapeutic ultrasound in stroke independent of its effect on the occlusive thrombus. ..
  54. doi request reprint Functional screening for G protein-coupled receptor targets of 14,15-epoxyeicosatrienoic acid
    Xuehong Liu
    The Knight Cardiovascular Institute, Oregon Health and Science University, Portland, OR, United States
    Prostaglandins Other Lipid Mediat . 2016
    ..Our data also indicate that none of the 105 GPCRs screened met our criteria for a high-affinity receptor for 14,15-EET...
  55. ncbi request reprint Ultrasound-enhanced thrombolysis in porcine clots in a flow system
    Azzdine Y Ammi
    Div of Cardiovascular Medicine, OHSU, 3181 SW Sam Jackson Park Rd, Portland, OR 97239
    J Acoust Soc Am 130:2502. 2011
    ..Mechanical clot reduction was observed in real-time in a flow system at various acoustic settings...
  56. doi request reprint Apical ballooning resulting from limbic encephalitis
    Jill Gelow
    Division of Cardiovascular Medicine, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Am J Med 122:583-6. 2009
    ..Neurogenic stunned myocardium is an increasingly recognized cause of left ventricular apical ballooning, or takotsubo cardiomyopathy. We report the first case of neurogenic stunned myocardium as a result of limbic encephalitis...
  57. ncbi request reprint What lies beyond a chronically occluded coronary artery, and what should we do about it?
    Sanjiv Kaul
    J Nucl Cardiol 10:92-4. 2003
  58. ncbi request reprint Dobutamine versus dipyridamole for inducing reversible perfusion defects in chronic multivessel coronary artery stenosis
    Jian Ping Bin
    Cardiovascular Imaging Center, The Cardiovascular Division, University of Virginia, Charlottesville, Virginia, USA
    J Am Coll Cardiol 40:167-74. 2002
    ....
  59. ncbi request reprint Direct effects of dobutamine on the coronary microcirculation: comparison with adenosine using myocardial contrast echocardiography
    Jian Ping Bin
    Cardiovascular Imaging Center, The Cardiovascular Division, University of Virginia, Charlottesville 22908, USA
    J Am Soc Echocardiogr 16:871-9. 2003
    ..In the bed with a noncritical stenosis, the increases in MBF and VEL are similar for both drugs. Similar to intracoronary adenosine, intracoronary dobutamine also caused capillary derecruitment distal to a noncritical coronary stenosis...
  60. ncbi request reprint Determinants of microvascular flow
    Sanjiv Kaul
    Eur Heart J 27:2272-4. 2006
  61. ncbi request reprint A1-receptor blockade: a novel approach for assessing myocardial viability in chronic ischemic cardiomyopathy
    D Elizabeth Le
    Cardiovascular Imaging Center, The Cardiovascular Division, University of Virginia School of Medicine, Charlottesville 22908, USA
    J Am Soc Echocardiogr 16:764-9. 2003
    ..Aminophylline or a selective A(1) adenosine receptor antagonist can be used to detect viable myocardium and may be safer than dobutamine in severe chronic ischemic heart disease...
  62. ncbi request reprint Automated, nonrigid alignment of clinical myocardial contrast echocardiography image sequences: comparison with manual alignment
    J Alison Noble
    Department of Engineering Science, University of Oxford, Oxford, UK
    Ultrasound Med Biol 28:115-23. 2002
    ..The automated technique can be used for quick poststudy off-line analysis and has the potential to be incorporated into an ultrasound machine...
  63. ncbi request reprint Skin perfusion assessed by contrast ultrasound predicts tissue survival in a free flap model
    Jonathan P Christiansen
    Cardiac Imaging Center, The Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Ultrasound Med Biol 28:315-20. 2002
    ..We conclude that skin perfusion can be assessed with CEU. Perfusion 18 h following a secondary ischemic insult in a free flap accurately predicts subsequent tissue survival in this model...
  64. ncbi request reprint Detection of peripheral vascular stenosis by assessing skeletal muscle flow reserve
    Thanjuvar Bragadeesh
    Cardiovascular Imaging Center, Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, Virginia
    J Am Coll Cardiol 45:780-5. 2005
    ..We sought to determine whether the severity of peripheral arterial disease (PAD) can be assessed by measuring blood flow reserve in limb skeletal muscle with contrast-enhanced ultrasound (CEU)...
  65. pmc Transmyocardial revascularization ameliorates ischemia by attenuating paradoxical catecholamine-induced vasoconstriction
    D Elizabeth Le
    Division of Cardiology, University of Virginia, Charlottesville, VA, USA
    J Nucl Cardiol 14:207-14. 2007
    ..The mechanism by which transmyocardial revascularization (TMR) offers clinical benefit is controversial. We hypothesized that TMR ameliorates ischemia by reversing paradoxical catecholamine-induced vasoconstriction...
  66. ncbi request reprint Microvascular remodeling and accelerated hyperemia blood flow restoration in arterially occluded skeletal muscle exposed to ultrasonic microbubble destruction
    Ji Song
    Dept of Biomedical Engineering, Univ of Virginia, Box 800759, UVA Health System, Charlottesville, VA 22908, USA
    Am J Physiol Heart Circ Physiol 287:H2754-61. 2004
    ..We conclude that ultrasonic microbubble destruction can be tailored to stimulate an arteriogenesis response that restores hyperemia blood flow to skeletal muscle in a rat model of arterial occlusion...
  67. ncbi request reprint Microvascular rheology of Definity microbubbles after intra-arterial and intravenous administration
    Jonathan R Lindner
    Cardiac Imaging Center, The Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, USA
    J Am Soc Echocardiogr 15:396-403. 2002
    ..Microbubble entrapment within the pulmonary microcirculation after venous injection should be negligible and transient. These findings are important for establishing the safety of this agent...
  68. ncbi request reprint Mechanism of inducible regional dysfunction during dipyridamole stress
    Jian Ping Bin
    Cardiovascular Imaging Center, The Cardiovascular Division, University of Virginia, Charlottesville 22908, USA
    Circulation 106:112-7. 2002
    ....
  69. ncbi request reprint Myocardial perfusion assessment in patients with medium probability of coronary artery disease and no prior myocardial infarction: comparison of myocardial contrast echocardiography with 99mTc single-photon emission computed tomography
    Roxy Senior
    Department of Cardiovascular Medicine, Northwick Park Hospital, Harrow, Middlesex, United Kingdom
    Am Heart J 147:1100-5. 2004
    ..This study was developed to test the hypothesis that MCE is superior to SPECT for the detection of CAD...
  70. ncbi request reprint Contrast ultrasound targeted drug and gene delivery: an update on a new therapeutic modality
    Richard J Price
    Department of Biomedical Engineering, University of Virginia, Health Sciences Center, Charlottesville, VA 22908, USA
    J Cardiovasc Pharmacol Ther 7:171-80. 2002
    ..Recent work in the emerging field of contrast ultrasound-based therapeutics, with particular emphasis on the delivery of drugs and genes to tissue through microvascular networks is reviewed...
  71. ncbi request reprint Stimulation of arteriogenesis in skeletal muscle by microbubble destruction with ultrasound
    Ji Song
    Department of Biomedical Engineering, University of Virginia, Charlottesville 22908, USA
    Circulation 106:1550-5. 2002
    ..We tested the hypothesis that this bioeffect could be used to stimulate the growth and remodeling of new arterioles via natural repair processes, resulting in an increase in skeletal muscle nutrient blood flow...
  72. ncbi request reprint Meeting highlights of the 14th annual scientific sessions of the American Society of Echocardiography: June 11 to 14, 2003, in Las Vegas, Nevada
    Linda D Gillam
    Hartford Hospital, Hartford, Connecticut 06102 8000, USA
    J Am Coll Cardiol 42:2149-55. 2003
  73. ncbi request reprint Impact of revascularization and myocardial viability determined by nitrate-enhanced Tc-99m sestamibi and Tl-201 imaging on mortality and functional outcome in ischemic cardiomyopathy
    Roxy Senior
    Department of Cardiovascular Medicine, Northwick Park Hospital and Institute of Medical Research, Harrow, United Kingdom
    J Nucl Cardiol 9:454-62. 2002
    ..Nitrate-enhanced perfusion imaging has been shown to detect viability in dysfunctional myocardium, but nitrate-enhanced technetium 99m sestamibi has not been compared with nitrate-enhanced thallium 201...
  74. ncbi request reprint Assessment of endogenous and therapeutic arteriogenesis by contrast ultrasound molecular imaging of integrin expression
    Howard Leong-Poi
    Cardiovascular Imaging Center and Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, USA
    Circulation 111:3248-54. 2005
    ..We hypothesized that molecular imaging with contrast-enhanced ultrasound (CEU) and microbubbles targeted to endothelial integrins could be used to noninvasively assess early angiogenic responses to ischemia and growth factor therapy...
  75. ncbi request reprint Myocardial contrast echocardiography, single-photon emission computed tomography, and regional function analysis for coronary stenosis description during vasodilator stress
    Wolfgang Lepper
    Medical Clinic I, Aachen, Germany
    Am J Cardiol 91:445-8. 2003
  76. ncbi request reprint Imaging tumor angiogenesis with contrast ultrasound and microbubbles targeted to alpha(v)beta3
    Dilantha B Ellegala
    Department of Neurosurgery, University of Virginia School of Medicine, Charlottesville, USA
    Circulation 108:336-41. 2003
    ..We hypothesized that contrast-enhanced ultrasound (CEU) with microbubbles targeted to alpha(v)-integrins expressed on the neovascular endothelium could be used to image angiogenesis...

Research Grants4

  1. ECHOCARDIOGRAPHIC ASSESSMENT OF MYOCARDIAL PERFUSION
    Sanjiv Kaul; Fiscal Year: 2002
    ..The ultimate aim is the further understanding of the role of capillaries in the local regulation of MBF. ..
  2. ECHOCARDIOGRAPHIC ASSESSMENT OF MYOCARDIAL PERFUSION
    Sanjiv Kaul; Fiscal Year: 2004
    ..The ultimate aim is the further understanding of the role of capillaries in the local regulation of MBF. ..
  3. CHRONIC ISCHEMIC LEFT VENTRICULAR DYSFUNCTION
    Sanjiv Kaul; Fiscal Year: 2004
    ..The drug we will test is carvedilol because of its unique adrenergic inhibitor properties as well as its anti-oxidant and anti-apoptotic properties. ..
  4. CORONARY MICROCIRCULATION-ACUTE MYOCARDIAL INFARCTION
    Sanjiv Kaul; Fiscal Year: 2004
    ..The study aims will be to test the 4 above-mentioned hypotheses in patients with suspected AMI. ..